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<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NF13</accession>
    <name>A0A162NF13_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_160007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287024.1">
        <property type="nucleotide sequence ID" value="XM_018434098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NF13"/>
    <dbReference type="GeneID" id="28995004"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160007"/>
    <dbReference type="InParanoid" id="A0A162NF13"/>
    <dbReference type="OrthoDB" id="2404656at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="82" mass="8962" checksum="159AEF3BC7E45612" modified="2016-07-06" version="1">MSGFRKEIHGMLVALVMTKTALKEWFLEGSSGERTVNLDKTIDDSIKQLSSLILMLKGIANSHLNGNSNTLLAKKAFGIQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NFR5</accession>
    <name>A0A162NFR5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_73946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287194.1">
        <property type="nucleotide sequence ID" value="XM_018442954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NFR5"/>
    <dbReference type="STRING" id="763407.A0A162NFR5"/>
    <dbReference type="GeneID" id="29003860"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73946"/>
    <dbReference type="InParanoid" id="A0A162NFR5"/>
    <dbReference type="OrthoDB" id="2286841at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF34">
        <property type="entry name" value="NOTOCHORD-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="436" mass="50156" checksum="CB688EDCD041A95B" modified="2016-07-06" version="1">MTTCILHPKFCERNSHLSHPLYEREKSRENIAADIWRDFRNQYLRTFAVGTQILLDLQSFDPLQDTPIEILHVILLGIAEYLVNDLVNSVLVKKDELRQLMGYLKDYKQSKGMSRKFTRLLSGCASYLARDYKCLIQILPVILVIKFTGNPVLKNITPCFIQLGQLCSLVFVRAIESGLETYIHEVDTAVKGLIKQLLVYDKNCELNRHNPYTSKLKAHLLTHLPDNIRRFGTPLHFETEKGEQFNKHIREHLFHTNKLNTSKDIGLKFAKQTMMRHILDGGSWPVENGLRLSRGKGIKTYIDYTASVHKFWNVLFGGSREFADNNDDGSIVNSELCDDTFALFMPMHGGSQTVHPIIEKVSSSQVIHLHIDLPTDIAQKNNYLLAREYSGMSTLLEELKMIRILDMYTKVGDAYVINLSKFGSYWHFYPYFSTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NH45</accession>
    <name>A0A162NH45_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphoglycerate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_133227</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292238.1">
        <property type="nucleotide sequence ID" value="XM_018429555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NH45"/>
    <dbReference type="FunCoup" id="A0A162NH45">
        <property type="interactions" value="363"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NH45"/>
    <dbReference type="GeneID" id="28990461"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_133227"/>
    <dbReference type="InParanoid" id="A0A162NH45"/>
    <dbReference type="OrthoDB" id="418179at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04901">
        <property type="entry name" value="ACT_3PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12176">
        <property type="entry name" value="PGDH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000041">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050418">
        <property type="entry name" value="D-iso_2-hydroxyacid_DH_PdxB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008759">
        <property type="entry name" value="PRK11790.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="6">
        <location>
            <begin position="34"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="7">
        <location>
            <begin position="138"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD74198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="48402" checksum="ACBC05EC4339BD68" modified="2016-07-06" version="1">MATQSPTEAAPRRSSFVQPKPRALRPFNTSEVKILLLENINETAVKSFLKQGYQVETYSKALVGDELLEKIKDVHVVGIRSKTKLTKQVLNAAVNLKVVGCFCIGTNQVDLHAAAHRGIAVFNSPFSNSRSVAELVIGEMIVLARQLGDRNIEMHYETWNKVSKRCFEIRGKVLGIVGYGHIGSQLSVLAESMGMTVYFHDVLQIMPLGTAKQTETLEELLSISDFVSLHVPELEETREMIGEREIMGYMKKGSYLLNNARGTVVQIPGLIKGLQSGHLAGAAIDVFPKEPASNGRHFTEYPELLKCPNIIMTPHIGGSTEEAQRMIGIEVSSALIKYINEGTSIGAVNFPEIDLRVIREDDKNTVRVLYIHRNIPGVLKAINEIFADHNVEKQYSDSKGDIAYVMADIANVAEEQLHQIYDAIIATPANISTRMLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NH92</accession>
    <name>A0A162NH92_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein bS18m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_78303</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287674.1">
        <property type="nucleotide sequence ID" value="XM_018443354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NH92"/>
    <dbReference type="FunCoup" id="A0A162NH92">
        <property type="interactions" value="205"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NH92"/>
    <dbReference type="GeneID" id="29004259"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_78303"/>
    <dbReference type="InParanoid" id="A0A162NH92"/>
    <dbReference type="OrthoDB" id="21463at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_bS18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479:SF40">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS18M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD69634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="184" mass="21055" checksum="AFD639D5801526CB" modified="2016-07-06" version="1">MFAQVRTLSTLSGVMRTPIVRALPLTHRSMTTAASNSQSKPERTIEKKTLALLEDSIKKEKSRPVVEAVQRYQKIHRVGDTYHPEDLNDTRYQESLRQRRGRPVTPAVDPFDALGLDPLHEYKNFRLLSHFVSDMGKILPRTQTGVSAKNQRKLAHAVKRARAMGLMSCTSKYVSPMQYWKNTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NIH4</accession>
    <name>A0A162NIH4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_167945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292578.1">
        <property type="nucleotide sequence ID" value="XM_018435757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NIH4"/>
    <dbReference type="GeneID" id="28996663"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167945"/>
    <dbReference type="InParanoid" id="A0A162NIH4"/>
    <dbReference type="OrthoDB" id="2289025at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007838138" evidence="1">
        <location>
            <begin position="18"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="191" mass="21908" checksum="3417F8981C712BCE" modified="2016-07-06" version="1">MTFVFFQLLIFPEFASTNCRISVNGKEKQATTKPTTWINIIYKASLSKQIGSVEVKTQYRALNHRLVGIDLIRITALVNSASDKHRLKVIFAFIAFAKYSTSYILHCVQTHLYTMCESAHIQPPLTFDQKPLFLSQVNKIIKAIACFQYIINSDNHNRVNGQTTLTDNILFHVTDPKLTRERKSITGHYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NIW3</accession>
    <name>A0A162NIW3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_71523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288124.1">
        <property type="nucleotide sequence ID" value="XM_018442492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NIW3"/>
    <dbReference type="GeneID" id="29003398"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71523"/>
    <dbReference type="InParanoid" id="A0A162NIW3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="252" mass="27530" checksum="EE54E304F8611BB3" modified="2016-07-06" version="1">MPNNNTGLELVMYAPTTRPAGSHVDGNVANPVLAMLASLNAQMKSLTDQIASMATGITKSNDTITRLQETVANIVSDQTVVQNTASRYNVTSGVEAVTGLSLLMEDDYVPGKRHPAILPGLVLTSYFTGGYNHGLALALTAYLRSQPQSDGILTSDLARMVKNYFCNQVRESCRMPSSANRKRTASRRHQCSLLLLHRHSMAYLENKEVIDMVTKRDNCAHVLQKTVMSDDETDNEATRSANSKCLKAHCPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NKI7</accession>
    <name>A0A162NKI7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_78913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293108.1">
        <property type="nucleotide sequence ID" value="XM_018443401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NKI7"/>
    <dbReference type="GeneID" id="29004306"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_78913"/>
    <dbReference type="InParanoid" id="A0A162NKI7"/>
    <dbReference type="OrthoDB" id="2265046at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007838182" evidence="1">
        <location>
            <begin position="19"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="136" mass="15124" checksum="73F5BF52AD03CC73" modified="2016-07-06" version="1">MQFFKISLLFALAIQAMAAKDDQSTGTTNIRQSVSPRPRQFRMDVYPQSNLKGTPQHMVSNNGVTSPCWNLDSKHIRSLVVNDPMIKITFYRSSDCRGASSKTIRSTRAHDGAQNLSLKAGSVKIVKLQQLVVTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PFV7</accession>
    <name>A0A162PFV7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_71023</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV441029">
        <property type="protein sequence ID" value="OAD65306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283346.1">
        <property type="nucleotide sequence ID" value="XM_018442394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PFV7"/>
    <dbReference type="GeneID" id="29003300"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71023"/>
    <dbReference type="InParanoid" id="A0A162PFV7"/>
    <dbReference type="OrthoDB" id="5401177at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007838275" description="DDE Tnp4 domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="38"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD65306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="182" mass="21430" checksum="A9480586198D1E06" modified="2016-07-06" version="1">MRVCFCSFIVLFSAENCKTFAEAIYEKSWVYKHIVGFVDGTMQKICCSQEKADQKIIYNGWKHIHCLKYQAIVTPDDITNSLLGPFTGFTHNVRMFDESRTLDCLILHLSTLTPERNSGLHYVIYGDQAYQKLLYVYRPFTVYEIKDHPSLKEVNRKMSQTRVQVEMEFGKVSQYFKYCKYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PGF0</accession>
    <name>A0A162PGF0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_146756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290607.1">
        <property type="nucleotide sequence ID" value="XM_018431716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PGF0"/>
    <dbReference type="GeneID" id="28992622"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146756"/>
    <dbReference type="InParanoid" id="A0A162PGF0"/>
    <dbReference type="OrthoDB" id="2242631at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF72">
        <property type="entry name" value="IM:7136021-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="4"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="684" mass="79158" checksum="3932A09BB4CED9CC" modified="2016-07-06" version="1">MLASELPFEIILCIARFLPIESKRCCANVCKSWKAPFKSMLWDSITIKNTKEMKNICDPAHSRHKPFKSNGKRTRSLTLDRDVTTSHVQFTHLQKLLPNIRCLYIEHLCLSIPDLGKLNWKPWKSLTVLGLKLSQMESPGEKDRLLEILSFLPCLVKLDLAETCMPWGKNRGPNNLDKLHSYLPRLSSLSIYVNHTDFDDDDYDPTAMIEPAINLTELNVTGPGIHLLWYIIRKYPNLRSLKTLSLEKGYSSNFDPQKLIYALGTLSHGFSFLRNIGIATKTSTKYHLEIWKQISLLNIKLRNIGLDLGRGDRYKEEDSETTFYRIVTPHANIVESLCINMKDEFMSPRIFMPLYSLQCYPCLVSLYLEIHNASYCLDVILNSCPELRTLSFSNAWLYISPGGSANDPKHGLKHIDLMLVDVYTSVLGYLSYRCRDLEHMSLDSAIIFDTFSKGPEKLCIDMSYTCFKYLLIRCIGFGKPRSDLYKKGDVSIMVLSESTIDPQLKNKKRSKAIVNNNALSKAPIKNTWYYISYAEETSGGTFSFMWKLRKHEIEFARKHFNLPLDNKNSYEIDDCTGPMEHYPGRRAFLKRRRAKQREFLDPDSDIVECSRCYNNYECEGSDCSDNDFHDSSRKFLKKRDFYDITGSFKKGNQHTDRRERWEKDVPDGYVTFKCGYIEQYKSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PLD7</accession>
    <name>A0A162PLD7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="16">1.3.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">2-methyl branched chain acyl-CoA dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">2-methylbutyryl-coenzyme A dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">PHYBLDRAFT_178018</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="32" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(2R)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65296"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156439"/>
            <dbReference type="ChEBI" id="CHEBI:156440"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:65297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(2S)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48256"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:88166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:48257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57336"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:43781"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:44180"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62500"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:44181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:24004"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:24005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:43465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>valproyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65344"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156457"/>
            <dbReference type="ChEBI" id="CHEBI:156458"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:65345"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 27">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Amino-acid degradation; L-isoleucine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 27">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.5" evidence="16"/>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD70006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288046.1">
        <property type="nucleotide sequence ID" value="XM_018437941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PLD7"/>
    <dbReference type="STRING" id="763407.A0A162PLD7"/>
    <dbReference type="GeneID" id="28998847"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_178018"/>
    <dbReference type="InParanoid" id="A0A162PLD7"/>
    <dbReference type="OrthoDB" id="10262177at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003853">
        <property type="term" value="F:short-chain 2-methyl fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046395">
        <property type="term" value="P:carboxylic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000012">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF1">
        <property type="entry name" value="SHORT_BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 27" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7 27" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 27" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="30">
        <location>
            <begin position="51"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="29">
        <location>
            <begin position="166"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="28">
        <location>
            <begin position="272"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00051903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="OAD70006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="425" mass="46370" checksum="B3399C566AAE2395" modified="2016-07-06" version="1">MSFIRSALRLSAATAIRPASVFRQAAQRNYAALTYSTPTVSENPTSLTAFTEEELMLKETVARFAREVVAPRVSAMDEAEKMDSDIIKAMFDNGLMGLETPGDYGGAECSFTAAILAVEELAKIDPSISALCDIHNTLTNTVIRKWANESLKEKYLTRLATDTVGSFAISEAGAGSDAFGLQTRAEDKGDHYILNGGKMWISNSAEAGIFVIFANVDPSKGYKGITAFIVEKEWGVEIAKKEKKLGIRSSSTCVLNFDDVRIPKENVLGEVGHGYKYAIDSLNEGRIGIAAQMIGCAQGAFDIALPYMMERKQFGTAIGNFQAMQHQFAQVAVDIEAAKLLTYNAARLKEENKPFVMEAAMAKFMAAKVAEKASSYAVEWMGGNGFVRETGVEKFYRDSKIGSIYEGTNNIQLQTIAKIIATKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PPD1</accession>
    <name>A0A162PPD1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Glutathione reductase</fullName>
            <ecNumber evidence="3 16">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">NDE4</name>
        <name evidence="19" type="ORF">PHYBLDRAFT_125895</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 16">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 16">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="3 16"/>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289706.1">
        <property type="nucleotide sequence ID" value="XM_018429066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PPD1"/>
    <dbReference type="FunCoup" id="A0A162PPD1">
        <property type="interactions" value="597"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162PPD1"/>
    <dbReference type="GeneID" id="28989972"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_125895"/>
    <dbReference type="InParanoid" id="A0A162PPD1"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000003">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000235">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13 15" id="KW-0274">FAD</keyword>
    <keyword evidence="5 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="18">
        <location>
            <begin position="12"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="17">
        <location>
            <begin position="359"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="188"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="14">
        <location>
            <begin position="51"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAD71666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="470" mass="50901" checksum="C3B8821061C9220C" modified="2016-07-06" version="1">MPPVPKPSKQLYDYLVIGGGSGGLASARRASGIHGAKVALIEAQHRLGGTCVNVGCVPKKVMWNAASIAEALRDAKGYGFDVQGKPSIDWNYIKTKRDAYVKRLNGIYERNLEKDSVEHFQGFASFVNPTTVRVQQTETESFEISAKHILVATGGHPIIPNIPGAELGIDSDGFFDLEEQPKRVAVVGTGYIGVELAGIFNALGSQTTIFSRTKHILRTFDEIIREPLLKEMESVGVQFAFDSKVKSLSRASTSGPIRIDYESDGQAASIEVDCVLWAVGRAPNVQKLNLEGAGVKTNEKGHIVVDSYQATSSEGVLALGDACGLFELTPVAIAAGRRLADRLFGGEAFRNSKLDYENIPTVVFSHPTAGTLGLTETEARKKYGDDQIKIYQSKFTNMYFSMLEHKEPTAYKLVVAGPEEKVVGVHLLGRGSDEMLQGFGVAVRMGATKADFDNCVAIHPTASEELVTMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PTP7</accession>
    <name>A0A162PTP7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_74782</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
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            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
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            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291886.1">
        <property type="nucleotide sequence ID" value="XM_018443033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PTP7"/>
    <dbReference type="FunCoup" id="A0A162PTP7">
        <property type="interactions" value="387"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162PTP7"/>
    <dbReference type="GeneID" id="29003939"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_74782"/>
    <dbReference type="InParanoid" id="A0A162PTP7"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF134">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD73846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="303" mass="34846" checksum="4B0D8A078B2D0BAB" modified="2016-07-06" version="1">MTLVHFSIDRPFGVYFFDIFDKLGYLATGSRASEFTFVPGVTRFSTLSEVIITCLTYYAVIFGGEYMMRNSAPFKFKTLFQIHNLLLTAVSGTLLLLLVEQLIPMLSKRGLYYALCDPSSLTTELNVIYYLNYLVKFWELADTVFMVAKKKKLEFLHYFHHSMTLALCYSQIVGGTTVSWVPIVLNLTVHVLMYYYYFRTSSGAKIWWKKYLTSMQITQFVIDLLVVYTCSYTYYAYNYAQILPNFGNCAGKESAAIFGCSLLTSYLFLFINFYRLTYNAQQKKIADAKATSVKPAKKIVEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q5C3</accession>
    <name>A0A162Q5C3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_59252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298266.1">
        <property type="nucleotide sequence ID" value="XM_018440461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q5C3"/>
    <dbReference type="GeneID" id="29001367"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_59252"/>
    <dbReference type="InParanoid" id="A0A162Q5C3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="109" mass="12746" checksum="765E7C4470571603" modified="2016-07-06" version="1">MTEGFALCIYPYLLCHSYDYLHYTETDTYILRKMKISMCLMFPFWITQLSLLGNIAYITIVHECGEEKKKIGYYGFVNDEASTEYDVLTLSKKEKACESKQPELNVLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T3F7</accession>
    <name>A0A162T3F7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bifunctional chorismate mutase/prephenate dehydratase</fullName>
            <ecNumber evidence="6">4.2.1.51</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Chorismate mutase-prephenate dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">p-protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PHYBLDRAFT_80517</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>prephenate + H(+) = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="6"/>
    <dbReference type="EMBL" id="KV441007">
        <property type="protein sequence ID" value="OAD65972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284012.1">
        <property type="nucleotide sequence ID" value="XM_018443591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T3F7"/>
    <dbReference type="FunCoup" id="A0A162T3F7">
        <property type="interactions" value="369"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162T3F7"/>
    <dbReference type="GeneID" id="29004496"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_80517"/>
    <dbReference type="InParanoid" id="A0A162T3F7"/>
    <dbReference type="OrthoDB" id="983542at2759"/>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04905">
        <property type="entry name" value="ACT_CM-PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13630">
        <property type="entry name" value="PBP2_PDT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000034">
        <property type="entry name" value="Chorismate mutase/prephenate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="entry name" value="Chorismate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008865">
        <property type="entry name" value="PRK11898.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022">
        <property type="entry name" value="PREPHENATE DEHYDRATASE P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022:SF19">
        <property type="entry name" value="PREPHENATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="Chorismate mutase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="18">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Prephenate dehydratase" evidence="19">
        <location>
            <begin position="97"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="20">
        <location>
            <begin position="284"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OAD65972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="366" mass="40470" checksum="847B7913FF7A75DC" modified="2016-07-06" version="1">MSDLPSLRKKIDTLDTTLVNILNERARVSLDIGAAKRQLDNTEGLPTTDLHVYMPGREKEVYAKLTRLNHGPLKDDSLHAIFREVMSASISLQKDVSMAYLGPPGTFSHQAAYQRLGDSVVYVPQKQISDVVDAVEKGQTTYGIVPFENSNFGSVVETLDRFVKTKTRVRAETYLTVHQCLLSNSPLDKITKVYSHPQGLGQTQMWLAANVPNAKRISVKSTAEAAQQAALETGAAAVCSEICAELYGLEVTARDIEDGAANTTRFLIIGTSSDNATKDDHTLIKFTVDHRQPGALCDGLKVFKDYSLNLFKIDSRPSGLHPWHYVFFVECSGHQQNEDVQKAVKDLDQFCLDVVVLGSFPNQRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TAM7</accession>
    <name>A0A162TAM7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_67364</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441025">
        <property type="protein sequence ID" value="OAD67232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285272.1">
        <property type="nucleotide sequence ID" value="XM_018441785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TAM7"/>
    <dbReference type="STRING" id="763407.A0A162TAM7"/>
    <dbReference type="GeneID" id="29002691"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_67364"/>
    <dbReference type="InParanoid" id="A0A162TAM7"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050460">
        <property type="entry name" value="Distal-less_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327:SF41">
        <property type="entry name" value="BRAIN-SPECIFIC HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327">
        <property type="entry name" value="HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="267"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="269"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="123"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="53"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="123"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD67232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="343" mass="37726" checksum="E667F8032E7961F3" modified="2016-07-06" version="1">MSNINRPLCIIKIQKPSKIHKSKMVRCSTPTPNRRGSLAISALLNQEPVDPITTTNRNNSFSSSDEGSIGGSSISISTSSNSNTDSSSSRSSSDSNAHSTNMSTTSTSTSISISNIINTTTTTTTTTTTTTPAAASTANTSAASATRSNRNRTRNNPITAPTVRVKNQRRQSYRLSVPAYMPPPNQNNNNNNNNNNNNNDNDQTQTQTQNQGQGQGQGQGQGKNQETVYYDFDVTDIETQNIEGTDYLWNNTTTGIRHFEGGYIVTAIAKAKRKRISEQQYAGLVDVFNVTDTPSSDVRERLARDLEMTKREVQVWFQNRRAKQSRAKVQERRLKEALSTLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TK57</accession>
    <name>A0A162TK57_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription activator GCR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_174091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285813.1">
        <property type="nucleotide sequence ID" value="XM_018437184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TK57"/>
    <dbReference type="STRING" id="763407.A0A162TK57"/>
    <dbReference type="GeneID" id="28998090"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174091"/>
    <dbReference type="InParanoid" id="A0A162TK57"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022210">
        <property type="entry name" value="TF_GCR1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12550">
        <property type="entry name" value="GCR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription activator GCR1-like" evidence="1">
        <location>
            <begin position="199"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="280" mass="32202" checksum="73E360EFD75D58C8" modified="2016-07-06" version="1">MNPNAPSYSAATSDVNVRMMEAQVSTSREAEVNRPENTKRSYASKQKEYKDWCDEAFLIIPLENCYTVYGDKLHLFLKDCVVNRTHRRDTGKTIKSVEAFVETDVEPTDILLQRALPLMARKLIDMQNADSRFRREVLREFGVLHQKIDDLVSGRIPLWSLQEDGGERGGARSTEVQAFPVPANNSGPISQLPDISVWYRMSRDVQTMPDLWREWHVGLSGCVSVHKMETRCKRIVNLIKKYMVDNSVSEETAVELAEENQRTRRRTLDFLSKNSSQIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TKB2</accession>
    <name>A0A162TKB2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_127093</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287302.1">
        <property type="nucleotide sequence ID" value="XM_018429146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TKB2"/>
    <dbReference type="FunCoup" id="A0A162TKB2">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TKB2"/>
    <dbReference type="GeneID" id="28990052"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_127093"/>
    <dbReference type="InParanoid" id="A0A162TKB2"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF881">
        <property type="entry name" value="FI07970P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="168"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD69262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="322" mass="36482" checksum="B52AACB9E16F1AF6" modified="2016-07-06" version="1">MATLDKLPIIDFGSFDKEPVKVAQQVLDACKSIGFFYMTNHGIPLDKVDNAFEMAKGYFDLPSEEKRKFLIKEDNYGYSELYSETLDPDNQRQGDHKEGFNFKNFIDGKAYAPLPAFFEEREEAVKAFSYACQETSARVLEAFAIALEIPEDQGGRNWFKDRHHYNRKSGQVLRFLKYPRGGEVSYKEPVRAGAHSDYGSLTLLFQKDVPGLEVQASRAAWIPAPLVDGAVLVNVGDLMEFWTNGLFKSTLHRVTFLPEHNHLDRYSIPFFVHPEDGVLLTPIPSSIVPPHTAAGSEDETKKKPIMTAGEHLRHRLKATYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TMA7</accession>
    <name>A0A162TMA7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_173279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286313.1">
        <property type="nucleotide sequence ID" value="XM_018436983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TMA7"/>
    <dbReference type="GeneID" id="28997889"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_173279"/>
    <dbReference type="InParanoid" id="A0A162TMA7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="187" mass="21528" checksum="C5C535D2A96708FC" modified="2016-07-06" version="1">MAPSARIDQLNTENNPKDNLNKEQTNKSQRLKEAKEHPRTINMKTPKCSKSLGAAFWLKNCEVYARINRLRSRGGLTYKTFRTGTASRRYSLRDHQGKAIIQEIGSAYANRFQDLINQSKLETKEDTNTSRLCKRDIKKAFIADMISKELHREIKRNDLKTLAAAIEMILELSKEMDYDSDSEESEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TN12</accession>
    <name>A0A162TN12_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_150644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286513.1">
        <property type="nucleotide sequence ID" value="XM_018432526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TN12"/>
    <dbReference type="GeneID" id="28993432"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150644"/>
    <dbReference type="InParanoid" id="A0A162TN12"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="170" mass="18600" checksum="9ECA7862FBD1E6E8" modified="2016-07-06" version="1">MSHLPEVLFFRKRSIDMILLQLDQSESFEEKFEIEEQVQALLPAELASSFATSHTAPSLPEELCLRFSPSHVAFWDTQAQNIVGKLSGVPVSTPPAPNFPVHIPVTSSLPMSTPPAPVNPAAPAAPAAMTIPKSITAFTTAFRSSQPPAAYTEWALFGHKHGLRRRLFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TR89</accession>
    <name>A0A162TR89_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_148348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288472.1">
        <property type="nucleotide sequence ID" value="XM_018432071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TR89"/>
    <dbReference type="GeneID" id="28992977"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148348"/>
    <dbReference type="InParanoid" id="A0A162TR89"/>
    <dbReference type="OrthoDB" id="10256743at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039629">
        <property type="entry name" value="R3HDM4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32019">
        <property type="entry name" value="R3H DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32019:SF2">
        <property type="entry name" value="R3H DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="267" mass="30565" checksum="560F3AF2A04A9167" modified="2016-07-06" version="1">MAIGDSTVFFVQPGGQWIQPTGQQNTFANVSAAIAASEVVAPSRLHSLADDALKPKKTKKRPVEKDTLSRRSNLAIGKEGSRRRQRWDNNNFSENPVAVLYSEDLRPPGYSRSKNIFQWNNIAINEEEPESVEEENQHVPIRSIVPLSRSVRKDLKRAHLPLGLVSSYEDQLMRFIATQQRRPPGEVDAQDLCLVWEISDRFVRWFVHAMCDYYNLESFSETISSGRRITYICHKAHLASVTTGEECSIEVDWKVPQMLFVDYLRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TYG4</accession>
    <name>A0A162TYG4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 10">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 10">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_38250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 10"/>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288883.1">
        <property type="nucleotide sequence ID" value="XM_018440104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TYG4"/>
    <dbReference type="FunCoup" id="A0A162TYG4">
        <property type="interactions" value="272"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TYG4"/>
    <dbReference type="GeneID" id="29001010"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_38250"/>
    <dbReference type="InParanoid" id="A0A162TYG4"/>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000002">
        <property type="entry name" value="Glutamate--cysteine ligase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000001">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD70843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="629" mass="72051" checksum="F5374AD77CAD65FF" modified="2016-07-06" version="1">MGLLSLGTPLHWKEAKTHADHVRSHGIDQFLHIYHSQKGQKKQCLLWGDEVEYVVVDVDEKAKRTRLSLRVFEVLAELQVAEQEYLEGKTKVVPDALWRPEYGRFMIEGTPGEPYGATFQDLLTVEPSMKLRRRLALAAMKPNEKPMTLVNYPRLGCPDELVPPHEPNGKACQSMFVPDEIINPHARFPTLTANIRRRRGAKVEINVPIFHDTKTPKPFIDPTVLWDRTLFKHDKEAKEGAAKPDHIYMDAMAFGMGCCCLQITFQACNVDEARRLYDQLAPMTPVMLALTAAAPIFRGYLADVDCRWNVIAAAVDDRTREERGLEPLKNNRFVINKSRYDSIDTYLSTDPINKPKYNDLDLVYDHDIYDKLRKNDVDDLLAKHVSHLFIRDPLVIFKELLDQDDTKSSDHFENLQSTNWQTVRFKPPPPNSDIGWRVEFRSMEVQLTDFENAAFSVFIVLLTRVILSYGLNLYIPISKIDINMQTAQKRGAVLNEKFYFRKNIFNSHSDTQNEDDDDEYELMTVNEIINGKENGFTGFVPLIHHYLESTNIDVQTRCKLSSYLSLISRRASGELMTGAAYLRQFVMNHPAYKHDSVVSPEITFDLVETVDKIAKGELKVPELLGNFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U2V6</accession>
    <name>A0A162U2V6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_57688</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD71913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289953.1">
        <property type="nucleotide sequence ID" value="XM_018440245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U2V6"/>
    <dbReference type="FunCoup" id="A0A162U2V6">
        <property type="interactions" value="846"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162U2V6"/>
    <dbReference type="GeneID" id="29001151"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_57688"/>
    <dbReference type="InParanoid" id="A0A162U2V6"/>
    <dbReference type="OrthoDB" id="76105at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000004">
        <property type="entry name" value="rRNA-processing protein FCF1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="7">
        <location>
            <begin position="65"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD71913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="195" mass="22662" checksum="6C93E8826AF2E75D" modified="2016-07-06" version="1">MGKAKKTRKFAEVKRIISTKDSRLKENKEKLKKKEEEKEKAVVRQLPQVASSMFFQYNAALGPPYHVLVDTNFINFSIQNKLELVKSMMDCLYAKSIPCITDCVMAELEKLGPKYRIALKIARDPRFERLPCSHKGTYADDCLVQRIMQHRCYIVATCDRDLKRRIRKVPGIPIMYISSRKYVIERLPELGTNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U898</accession>
    <name>A0A162U898_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Serine/threonine protein kinase AGC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PKB4</name>
        <name evidence="11" type="ORF">PHYBLDRAFT_3228</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292302.1">
        <property type="nucleotide sequence ID" value="XM_018439994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U898"/>
    <dbReference type="STRING" id="763407.A0A162U898"/>
    <dbReference type="GeneID" id="29000900"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_3228"/>
    <dbReference type="InParanoid" id="A0A162U898"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000465">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="4"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="10">
        <location>
            <begin position="270"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD74262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="312" mass="36064" checksum="76C3AF165D01AFF2" modified="2016-07-06" version="1" fragment="single">ISDFQFIRVLGKGCMGKVLLSRSHRSHKLYALKAISKEWVITQREIEHTRTERDILTRIAHINHPFLIRLHHSFQSHHQLFLVLDYHVGGDLATQLAFWGRFTPDRCLLYTAEILLGLQELHRQGILYRDLKPENVLVGADGHLVLTDFGLSKQFKSDLSEMEHQRTRTFCGTPEYLAPEILQAQAYSYHVDFWSLGTILYEMLTGTTPFWAESRAEMYRRVMDDLLEFPPDLPPVTTDFIAGLLERDPAMRLGTGPGGDVLIRSHPYFDSLDWPDVYFKRIEPAYVPDLTSDTDVSHFDQDFVQMSPRLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UA31</accession>
    <name>A0A162UA31_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_144064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292732.1">
        <property type="nucleotide sequence ID" value="XM_018431136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UA31"/>
    <dbReference type="STRING" id="763407.A0A162UA31"/>
    <dbReference type="GeneID" id="28992042"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144064"/>
    <dbReference type="InParanoid" id="A0A162UA31"/>
    <dbReference type="OrthoDB" id="9994419at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="54784" checksum="0430385FB21463AB" modified="2016-07-06" version="1">MDTLSTELVQLCLQFCDSSRDIAQICRLNKKFYSITIQTLFKTVEIKGPAQYITFCRHMASMREKGLFKLVRHLDFMGYTTHGVRYSQEEARKAVTPEGFAQLLDECIDLRELSVTNELNHVFQDSSVIRSIFANHQRIESIDLIGFFQLKYANTMSSLFAQNVTMCDKDLHEKHEALCNKPSDYASTLPTQLPPITISSYLSRVSFYLNATLTQSEFFTPFFKLLKENNISLTRIDVGHTRVTNDIFNHILPQKLTHFGLQGCRMVSLDDNASQFFARCTNLQELNLNMRAGIVIPRNPGDAPPCYWFSPQSLSQLLLSCNKKKDLRVLHLGGQGELDDEILGSCKPTTHRLTHFSIAGASKVTAESFLDTLAQMPHLEYLDLSNTFFDTTIDGLQTTLFVIKESQYLDSLKVIEFCSSKTMRFPDTWLGWKFMTHNLRSYYFRQDVNPCYSMPQKLPAVGRIPRSAMERYWRFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UGR5</accession>
    <name>A0A162UGR5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_181056</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293133.1">
        <property type="nucleotide sequence ID" value="XM_018438409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UGR5"/>
    <dbReference type="FunCoup" id="A0A162UGR5">
        <property type="interactions" value="435"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UGR5"/>
    <dbReference type="GeneID" id="28999315"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_181056"/>
    <dbReference type="InParanoid" id="A0A162UGR5"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13986">
        <property type="entry name" value="STKc_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052239">
        <property type="entry name" value="Ser/Thr-specific_kinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998:SF2">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="31"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD75093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="372" mass="41875" checksum="C54453624CA1EFE9" modified="2016-07-06" version="1">MSFLTALFDAIVSATNMCIPNSNISINGRAYRIIKLLGEGGFSFVYLAQDGSGNLYALKKIRCNMGTTEEALAQREVEMYQLFSHKNIIRLLDSATVTESDDSKTIYIFLPYYKKGNLQDAISRNQLHSTHFSEEQALNIFRQVCEAVKALHTYTVKGVARDQYEANAPQSIQDENAQQARALLEEQTHQERSEPQQVQGTRGDLMPWAHRDIKPGNVLMSDDGVTPILMDFGSACKARIEIHSRQEALAQQDIAAEHCSMPYRAPELFDVKTDSVLDEKVDIWSLGCTLYAMAYGQSPFEMNMNEQGGSMALAVLNGQFKFPSGNGYEKQYSKEFRDLITWILNADPKARPDIHQTIAKVDELLARPRQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UHU1</accession>
    <name>A0A162UHU1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_158386</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293373.1">
        <property type="nucleotide sequence ID" value="XM_018433776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UHU1"/>
    <dbReference type="FunCoup" id="A0A162UHU1">
        <property type="interactions" value="869"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UHU1"/>
    <dbReference type="GeneID" id="28994682"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_158386"/>
    <dbReference type="InParanoid" id="A0A162UHU1"/>
    <dbReference type="OrthoDB" id="62956at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007840286" description="GOLD domain-containing protein" evidence="10">
        <location>
            <begin position="24"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="33"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD75333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="201" mass="22746" checksum="4218157119F3588F" modified="2016-07-06" version="1">MPTAIQLSFVLVFFSCLFSTVSLLHIDVAPHSKDCFYEDLNEGDKMTVSFQVGEGGNLDIDFWILDPRGTTIKRSEGDAKGNHVITALSTGRYTYCFNNGMSGKAAKAIDFNVYDMEKVSSSAAEHIDPIAREIRELAESIHAIKVEQEYIVARERQHRDTAESTNARVKWWSLGQLGLLMSVCVWQVLYLKRFFEVKRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UMR4</accession>
    <name>A0A162UMR4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_166382</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294453.1">
        <property type="nucleotide sequence ID" value="XM_018435411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UMR4"/>
    <dbReference type="STRING" id="763407.A0A162UMR4"/>
    <dbReference type="GeneID" id="28996317"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166382"/>
    <dbReference type="InParanoid" id="A0A162UMR4"/>
    <dbReference type="OrthoDB" id="18574at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF2">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="16"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="120"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="213"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD76413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="324" mass="36119" checksum="D2092CC0A5F49E40" modified="2016-07-06" version="1">MKKVHETLIPLEDYKLPPLGHAISGAVGSSIANLFVYPLDIATTRIQLNSKQAEKAKRQGLLETIATIYKTEGGIKGLYAGLGSDTVASVLSSFIYFYCYTALRNVQEKINTKMGKATQLNVAQELFLGAEAALISRLFTTPVSNVTTRLQTAGHHNKKGFVDMMKDIYEEKGITGFWTGYRASIMLVSNPSITYFVFEKVKDLYLRNSKNTLSSFQIFLLSAVSKSIATAITYPFIFVRTKMVADVKGKSAIENQKSILAIFKDTFEKEGASGIYKGIRAQIVKGFFNQGIMYMIKDYVATYLTLVFYASLKLKFRRQQASLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UPA9</accession>
    <name>A0A162UPA9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_109646</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294823.1">
        <property type="nucleotide sequence ID" value="XM_018428125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UPA9"/>
    <dbReference type="FunCoup" id="A0A162UPA9">
        <property type="interactions" value="691"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UPA9"/>
    <dbReference type="GeneID" id="28989031"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_109646"/>
    <dbReference type="InParanoid" id="A0A162UPA9"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000159">
        <property type="entry name" value="Casein kinase I hhp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="11"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD76783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="303" mass="35256" checksum="E23FD28670E756B5" modified="2016-07-06" version="1">MSMDLRVGNKYRIGRKIGSGSFGDIYLGTNIITSEEVAIKLESVKAKHPQLEYETKVYKALSGGVGIPFVRWYGTECDYNAMVMDLLGPSLEDLFNFCNRKFTLKTVLLLADQMLSRIEYIHSKNFIHRDIKPDNFLMGIGKRGNQVNVIDFGLAKKYRDPRTHLHIPYRENKNLTGTARYASINTHLGVEQSRRDDLESLGYVLMYFCRGSLPWQGQKAATKKQKYDRIMEKKMTTPTELLCRGFPSEFAIYLNYTRSLRFDDKPDYSYLRKLFRDLFVREGFLYDYVFDWTVVRIVSNISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UTA3</accession>
    <name>A0A162UTA3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_60915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295833.1">
        <property type="nucleotide sequence ID" value="XM_018440718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UTA3"/>
    <dbReference type="GeneID" id="29001624"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_60915"/>
    <dbReference type="InParanoid" id="A0A162UTA3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="102" mass="11276" checksum="86814D0E35F10464" modified="2016-07-06" version="1">MALVFVSVIYRIFFKATLIILVSLCFCASVQSTNAFWLWALSGNNSGVRLAPGPLILILNEEHHLAIFFLRIRVAGSSFRTGARLYSMTDYVGLGDCDRSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V1Q0</accession>
    <name>A0A162V1Q0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_139434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OAD79403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018430224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V1Q0"/>
    <dbReference type="GeneID" id="28991130"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139434"/>
    <dbReference type="InParanoid" id="A0A162V1Q0"/>
    <dbReference type="OrthoDB" id="2222405at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007840483" evidence="1">
        <location>
            <begin position="20"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="58" mass="6484" checksum="10377BD4AC446B6C" modified="2016-07-06" version="1">MKWLISVLLVLSAVISTQAVDLPNLRTLHNECSQNLVCLDGLYCRRYNGAVYGTCEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V2N9</accession>
    <name>A0A162V2N9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GRIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_58598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297592.1">
        <property type="nucleotide sequence ID" value="XM_018440359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V2N9"/>
    <dbReference type="STRING" id="763407.A0A162V2N9"/>
    <dbReference type="GeneID" id="29001265"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_58598"/>
    <dbReference type="InParanoid" id="A0A162V2N9"/>
    <dbReference type="OrthoDB" id="1926336at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="188"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD79552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="44745" checksum="98A0E577FEEA9813" modified="2016-07-06" version="1">MVNKKQNYSKQRLQEELSRLGNEIEELRMEREESKKNVLHFVQEADMARQDLQHAREQIAILSSKLNNSDHSPDLPSQSIDESQEHKQSQGDKILQLETLLSRATASLVEHEKAAEIHSRDAQNVIELTDQVKQLTTQLKDCQDTLGRLNESQKLIQDEFDQAKDENRVLRQTLKVEHERGERLESHWKSSENALEQAEIRVEVLKKEIEGLRQQQTWSPKIVQSDTSKIEALEKLQKALQQKYQMNLEQYSVLEQRLENEVKSHAHWKNAYEEKLKLLTLHQAREDEHNEMLDQSKVREQHLRTINKTLRDEIRKISRNRREVVNVEYLRNVILTFLEKKQTRSPSSQPYYNAPMWTKRTFTALFETRQHHKQIILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V4V7</accession>
    <name>A0A162V4V7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Myosin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHYBLDRAFT_106479</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298022.1">
        <property type="nucleotide sequence ID" value="XM_018427949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V4V7"/>
    <dbReference type="FunCoup" id="A0A162V4V7">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162V4V7"/>
    <dbReference type="GeneID" id="28988855"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_106479"/>
    <dbReference type="InParanoid" id="A0A162V4V7"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11856">
        <property type="entry name" value="SH3_p47phox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000015">
        <property type="entry name" value="Myosin I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000004">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000007">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF837">
        <property type="entry name" value="MYOSIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9 13" id="KW-0518">Myosin</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Myosin motor" evidence="16">
        <location>
            <begin position="14"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="17">
        <location>
            <begin position="747"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="1032"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="13">
        <location>
            <begin position="562"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="931"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1075"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="982"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1011"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1093"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1112"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="102"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAD79982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1205" mass="134150" checksum="656B5CD093DCED8F" modified="2016-07-06" version="1" fragment="single">ARADWKEGVKKKQVGVSDMTLLSQITNEAINENLMKRWLNQEIYTYIGHVLISVNPFKDLGIYSETVLESYKGKNLLEMPPHVFAIAEASYHHMNSYKENHGESGAGKTEAAKRIMQYIAAVSGGKSSSIQEIKDMVLATNPLLESFGCAKTLRNNNSSRHGKYLEIQFNDQGEPVGAVITNYLLEKNRVVGQIDNERNFHIFYQLTKAAPPEYQETFGLQGPESFLYTSRSGCLDVDDINDVTDFNETIKAMGVVGLQKTEQDEIFKMLSIILWLGNVIFVEDDNGNAAISDGDVANFIAYLMEVDGEALSKALTQRVMETQRGGRRGSVYEVPLNVTQANSVRNALAKSIYERLFEWIVTRVNKSLEARGVAQYMIGVLDIYGFEIFDDNNFEQLCINYVNEKLQQIFIELTLKAEQEEYVREQIHWTPIKFFNNKVVCELIEEKRPPGVFAALNDACATAHADSGAADNSFVQRLGFLSTNAHFESRGSKFLIRHYAGEVLYNIDGMTDKNKDSLLKDLLDLAASSTNQFISHTLFPERIDPNSKKRPPTAGDKIKASCNALVSKLMQCHPSYIRTIKPNDNRSSTEYDQKRVLHQVQYLGLCENIRVRRAGFAYRTTFEKFVERFYLLCPKTGYAGENIWNGDSVTGANEILRHNNIPADEWQMGTSKVFIRHPETIFALENLRDKYWHNMATRIQRAWRAHVRYKHECARKIQRFWRQNKYNIGYLQMRDYGNQILGGRKERRRFSLLSMRRFTGDYLDIKNGSGFSTMVRNAITFRSGEEVVFSMRGNTLVPRPMRSSVPSPRTFVLTNQSLHIVVATKNGKMVQMTDEKAISLSVINSASVSSMRDDWVVLHLDNSPDGDSILSCYFKTELLTHMLQQTNGRIKVNVNPQIQYAKKGGKSVTMKFVKDEKIKHDDVYKSHVVHVPTGEPANSQPFPSCPVKPRPVKQSAPRKAPGPRNPAAGRTSAPRPTPSQVAAPAAAPMAQHTTMASPMAGSQASRARAAPPAPAPVPVPAPAAPSPPQPAPGVPLFKAIYPFKSQEEGEIAFEKEDLLEIVEKDENGWWLARKDGKEGWVPSNYLEEYTPPRSSPPPPPPVARRAPPPPAASSQPSVASVASAIMPNGLGLGPPAPKPMIPAKPSAGGKPSVPSRPGGVASTPRAPPRPGSAAPPNAAASLADAVSYPWYIGQSLHLSYFCLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V6B4</accession>
    <name>A0A162V6B4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_160961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298352.1">
        <property type="nucleotide sequence ID" value="XM_018434323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V6B4"/>
    <dbReference type="GeneID" id="28995229"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160961"/>
    <dbReference type="InParanoid" id="A0A162V6B4"/>
    <dbReference type="OrthoDB" id="2265577at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="210"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD80312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="312" mass="35914" checksum="63D016DA62A83ECC" modified="2016-07-06" version="1">MPVSATARDHLSPLHNLMNYSIPLQDSSSMPSLPEVDLPKRTIQNGDSDTRQRQLGNEIEHLTLSNVRLLRANRILKLDCDRLVEQQTAQLKQDMEELRIHNIRLQRSNRLLQDDLLAKSQELNQLKEDQIRQMKNVGPEYEYLVQIVNLLYRQLEGQAGCNKTCCYTDQPLSQGFSVLTLPPESEEQKPEPQHICRPVIHSNISGGTMASALEQENAQLREGLQALHADQEQLYDLLRDKEEDAEMLKCELKLKDDIVTQLEKDFERMELEVVGIQKDWRYSDRFKSESSFADIHDFPTPPPQSDDDGQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WVJ0</accession>
    <name>A0A162WVJ0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_170503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289155.1">
        <property type="nucleotide sequence ID" value="XM_018436361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WVJ0"/>
    <dbReference type="GeneID" id="28997267"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170503"/>
    <dbReference type="InParanoid" id="A0A162WVJ0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="140" mass="16276" checksum="935BCB38BECA8369" modified="2016-07-06" version="1">MLRAYVYQSFECAMLCSTLIYHCDGWDIPTTVEWNTNSTTGGFLRKLVQLENKILIMLTKTITSVSNVFVCFRKGLAKQLCFFKVKRCSDAKRKIYVPKIRVSDVFLYDTNFLRNHTLETTCLELYNASDTSIITFNRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XCN0</accession>
    <name>A0A162XCN0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_64931</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292025.1">
        <property type="nucleotide sequence ID" value="XM_018441375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XCN0"/>
    <dbReference type="STRING" id="763407.A0A162XCN0"/>
    <dbReference type="GeneID" id="29002281"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64931"/>
    <dbReference type="InParanoid" id="A0A162XCN0"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007840985" description="Sodium/calcium exchanger membrane region domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="675"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="706"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="730"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="818"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="851"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="80"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="710"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="228"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD73985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="875" mass="96542" checksum="4F0DD7D2D3B046D2" modified="2016-07-06" version="1">MLKTYALLIIILSLVILVNSQEIDLEAHNHRQKACIDIESHVNQCSFVKDACKGLSGFYLRFYYCTSVWRPLVLITLFSGLLLLFGAVSVASADFFCPNLQSISAKLQLSESLAGVTILAFGNGSSDLFSTFSAMNSGSGSLAIGELIGAAFFIVAVVSGSVGIIRPFKSKRITFMRDAPFLAGATLILGWVVYIERIEWYHGLALILYYVTYVLVVFLSTYHSSATATLKNPSEDSPLLNTNNEEPKIFQNRRTKRKHKPPRLHIPDHGFLVTCNTSDHDPPLGSIIKPISPLPFDQPEASYIPLPISRAASNSGSFSSQSSSRAMAPRVGIRSSLFNAIEFHEQIASLRRVSSINTINLFNSPEGSLRSSSPQRSPRVPEWRISVDMSPSRNISAPDSCLNMPDVHLPHHNDYFSYISQNLAPAQPTSRDYDKETRLNEDMSIPTQCVPEIRLDPPQPLESERSLHHQYIDIYKRSTHGLSLPSPFASISPTLGTMPSPNSSENEWPSIPIHVKVVNVSSSDQISSCKKVREEYFNYALASESVISACQSVQKTLFPTLQFWESKTRFAKISSLAAAPLVLLFTITLPVVEYDTARNKASTPTLYRSPSPEININKKTYLSVNNFGPSYVDRVQEPEPELQQIPWCRWLLALQAITSTTFITAIMAGNGWVTYPHIMWGTVLGCILSIIVLVNTNPSQPPSWNWLLSIPGFIVALHWVFLLVNEMVSMLQALGIIFHISDAIMGLTIFALLRLTREYIKGNSMGDLVANTAIAEMGFPTMAISACYAGPLLNTVLGVGISSTYQILKSGKAYPLDISPTILISAGGLVVVLLSTIIVTSFNGCRVTRGLGWWMISVYCACCFTNVLIEFRVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XM90</accession>
    <name>A0A162XM90_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_143955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293745.1">
        <property type="nucleotide sequence ID" value="XM_018431109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XM90"/>
    <dbReference type="GeneID" id="28992015"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143955"/>
    <dbReference type="InParanoid" id="A0A162XM90"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31945" checksum="312D3094BCCCB148" modified="2016-07-06" version="1">MSNQNESYPTRRTPAEREMTNSLAILRRDMTTVMKDVADIKAKTLNTPVSAVLQSQPMALVHAVAPVSMEMNVAGSPTMASDAKSVNKTKAYRLLREHLWDPKFKSKHLAEIQANNGKPRWNTTVNFNQSPNTELTENLVAYLERKFVGAGLRKSDVRDFVYTNFTSRKRAANKSQAKKKSDNACNRRSNREKEHLKRRKTAYQSNKTAIDDKMKRDCSGLIIEEAMSVGESDDGTLPHYNHFITLVDNKVVADLGLNSHQLLSRAFGETVEGSVSDAIASQFPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XV76</accession>
    <name>A0A162XV76_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHYBLDRAFT_185794</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. Component of RNA polymerases IV and V which mediate short-interfering RNAs (siRNA) accumulation and subsequent RNA-directed DNA methylation-dependent (RdDM) transcriptional gene silencing (TGS) of endogenous repeated sequences, including transposable elements. Required for RNA silencing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the RNA polymerase II, IV and V complexes. Interacts with NRPD1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 15">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294685.1">
        <property type="nucleotide sequence ID" value="XM_018439144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XV76"/>
    <dbReference type="FunCoup" id="A0A162XV76">
        <property type="interactions" value="261"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162XV76"/>
    <dbReference type="GeneID" id="29000050"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_185794"/>
    <dbReference type="InParanoid" id="A0A162XV76"/>
    <dbReference type="OrthoDB" id="282270at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000419">
        <property type="term" value="C:RNA polymerase V complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10508">
        <property type="entry name" value="Zn-ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034012">
        <property type="entry name" value="Zn_ribbon_RPB9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11 15" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 12 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="16">
        <location>
            <begin position="71"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAD76645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="114" mass="13173" checksum="45DB26B84D3267FF" modified="2016-07-06" version="1">MASFKYCLECNNLLYPREDKSSRRLMFSCRNCQYEEDADNMCVYSHKIIHTPSEQTMMLTDLATDPTLPRANVTCPQCNHPEAVFFQSSSRRAEAKMTLFYVCGSQECGHRWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YA26</accession>
    <name>A0A162YA26_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_14871</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297355.1">
        <property type="nucleotide sequence ID" value="XM_018432137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YA26"/>
    <dbReference type="STRING" id="763407.A0A162YA26"/>
    <dbReference type="GeneID" id="28993043"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_14871"/>
    <dbReference type="InParanoid" id="A0A162YA26"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD79315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="64" mass="7275" checksum="1A0F1EC38695BBA7" modified="2016-07-06" version="1" fragment="single">FKAAVEELEKLTHKPSAADSMDLYGLYQQATIGDNETEMPSLDIKGRYNWDAWNNLNGVQMKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YCX1</accession>
    <name>A0A162YCX1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_75694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297895.1">
        <property type="nucleotide sequence ID" value="XM_018443089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YCX1"/>
    <dbReference type="STRING" id="763407.A0A162YCX1"/>
    <dbReference type="GeneID" id="29003995"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_75694"/>
    <dbReference type="InParanoid" id="A0A162YCX1"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="919"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="959"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="841"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="853"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="865"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1090"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1196" mass="133173" checksum="6ECCEBAFCAB7A012" modified="2016-07-06" version="1">MSNRNHADQDNQWIYELEKCQSKILGLPNKVMELICRFLPTRADQFNACLIHPIWETAARNILWEAPKFYEPASFRAFVNTVMTTKKCALAVRSLSMCADGPDDHAIFKPIDNSDLKLHDTQLTTLSNPSFIRFMASRCEKLKSLKIYGYNLESSHVETLASILSDLTDLHIIGNKRDPQDPSSPHPPPFVINSNILSRLRSLGLDGVFSITTSFSKTLATRCHNLQSIHLSLAGMSANGLAELCSHDILDLKELVFTHAAHIKDSHMTHVLKAFPNLVRLAVENAGHLTVETIRDAFTYSRFLEDLDIRGNSAYQLPLPNKDSGIDDEETWTVAPNMYRLAIHHLEISNTHLTHILRACPSLTVFGISDCDSLTDEPLEKSFGWLNKLEVAHIIQCKKIGSKTINAMIKKQTRKTIREVNFEGSGHIRPSDIYQLCRETHIHHLKTLRLVNYPELMDSTIGHFATVLQEKESIMILDEKAIELLVDTPMEQYSDLDQKPQARFLSGDQIIALATELQLSLPALEHILNKVQIMAPDSSEQESDENSSSSQVLHKYSNSEYDNQTNKSQAEYTDNSTERTTSQLSTQWPGTSLPLKTSEPETGVSSPEIQNRSSTQDYTSESERDTSGSLLSASSFIGSPSDRPEMDSTENINNEKSLGGWTQSDGQDWAKGAEISTLNPKANHDRKPAQGDSKQKDAMRWNASRGQPMSNGTANKKFNAVFGAEEGWGNVENVVPWEQTKGYVPDVLEAQSNTIYWEQTRDGEWSKLSARKFAELPPAANNQRLSTPISRTPRRRTRAGAGGGSFRSSDDSSDNSDSEVMRTDIVYNPAEGSFQPKTQKPTRTTALPTRPRSQSPKTTNLPKYTATTTTATPTTSTPTTIEGWNKFRASSTMSANLLPNSSSRNFRQPQPRAISGALRKKQGTVRQAIPPGKMTGSWGSYSAQATAVDDQRPHKLIDTDDIVQPHSNPPSTPEYTKPVNADLKMLAGIDLSFPKDDNENKQAHDTPSESNIPAEVIIWSNNSDSTSKQPPANSHQEQKHWGGLTVNKDQVEDVDTSKDSLLLPKDPIQTKEKGAELTPMPTSPPFLEPVSNQLLDSGTATPDKPVETSPTSSSKEKPGKRATFKISTKDHGVQCLLFFEGSNVQDCVEEFCKKYSMEDQVSILLDQVEEPFMKWKTDLVMKRHSKNNKKSKKSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Z969</accession>
    <name>A0A162Z969_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_153756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441014">
        <property type="protein sequence ID" value="OAD65161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283201.1">
        <property type="nucleotide sequence ID" value="XM_018433244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Z969"/>
    <dbReference type="STRING" id="763407.A0A162Z969"/>
    <dbReference type="GeneID" id="28994150"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153756"/>
    <dbReference type="InParanoid" id="A0A162Z969"/>
    <dbReference type="OrthoDB" id="2267579at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="214" mass="24493" checksum="AC3E77C05B2C2581" modified="2016-07-06" version="1">MNINELSPKQILELIKLGQQAQQRQRDYDGDNLPEEILKDLDEPSAKGLKSNIIRFTKDTLQFEGGKWTKSGAINQIFVPDLKKYTVDAHQIVQGKYKDGDKLRIAGRAASEVFNDLKYIKSQQSSNKDAADFDELIEKVRRLAVYAFASGKTLDEDAKELSIRAIKLPTRARYFEDEDDNDKDMAFDQEWVEKIQQARYEESVLQSAVSNKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZA89</accession>
    <name>A0A162ZA89_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CxC1-like cysteine cluster associated with KDZ transposases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_153485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441028">
        <property type="protein sequence ID" value="OAD65401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283441.1">
        <property type="nucleotide sequence ID" value="XM_018433163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZA89"/>
    <dbReference type="STRING" id="763407.A0A162ZA89"/>
    <dbReference type="GeneID" id="28994069"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153485"/>
    <dbReference type="InParanoid" id="A0A162ZA89"/>
    <dbReference type="OrthoDB" id="2505730at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="775"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="830" mass="94388" checksum="15452996F7144B1D" modified="2016-07-06" version="1">MYNPSKHTIKRRQRTAVPQFLLDYFSEDAPISGLNYIPTKKPSVSEVEFNSLRLQYTYARKKRARTMAVAPIEMPSKNIAASQIDLDVKIDFDTYEASQTQKRSLYNKWVDLLSQLADSFLRYLGRCKDGCLDKKVIALLSHFLSSGTFEVVFCRCKSIPKQLVEMGMLPASLNNVQYAIHFGLLEFMRDMRDVLAISGQGLANLYNKINLGAERQISNAYYQNLLHVFIRLMMIVEAKVEKLSSGFRESNCCPACPDVDSNVAVDDCQYVAMDGNFSLKCERKKDEAQLKQVWIGDDVMKMYEKERAEEGISQFDSNFHASSGGLAKSIKYSIKGLFAASCARHESVIKLVDMETGEGFKYPLSIINQLFGDSGSDDQSADNSPNINVIYDVVCKLAKSLKANFPGLMEKSKLAVPTFHVYAHVQHCQVKLNPKCRDGFGLTDGECLERLWSYLNRFVTMTRKMGQANRKLVLYRAIKFCNETKKVELGLMLESKYVKAKRIIEKSKKALEGFDCVVIEQEWKQHVNKVEKSENYVDIADLMESSHKVQGNIALLANDANGNHVKDEINRLKYEMEKLKMKIQKEVEGFQESDEENTNLIIYIEENVQLGYNEFLAYKKNIQRCTKKSKQHQTSLNKQAKQIIYLLQAFNLEFNESLTFDSIINKKNIFWDAEIRPEVHLFLAKKRAEEEVALLKCDAFWLQHCATKERTLREQGLKALDNAVGTLDKESLLRPVSFWNSRPLPPPFLLLPPPPFLLPPSPPFLLPPSPPFLLPPSPPFLLPPSPPHKPPDDGEASIAFVVEGDDDDDNDDDNNDDDDDDANDDANEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZTK2</accession>
    <name>A0A162ZTK2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_159981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286961.1">
        <property type="nucleotide sequence ID" value="XM_018434094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZTK2"/>
    <dbReference type="GeneID" id="28995000"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159981"/>
    <dbReference type="InParanoid" id="A0A162ZTK2"/>
    <dbReference type="OrthoDB" id="2274050at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="84" mass="9619" checksum="423642AAD1AE4DC7" modified="2016-07-06" version="1">MLDESIISEIQQTVCECTRDTPPQEPICTLKSCLKKLPEPPVAQKKKQKKSNKKRKRTLSKSENTYKDMQQAHSRLTPPSLSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ABW8</accession>
    <name>A0A163ABW8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_146631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290481.1">
        <property type="nucleotide sequence ID" value="XM_018431694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ABW8"/>
    <dbReference type="GeneID" id="28992600"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146631"/>
    <dbReference type="InParanoid" id="A0A163ABW8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="587" mass="67998" checksum="4AC8B85358EE82BF" modified="2016-07-06" version="1">MLVSELPFELLLQISSQLLPKDKLNCVLVCKGWEVPFQDSLWKDMEVRSSESLKRVCKVAKRSASGLSYGLAVQNLRLNGEYSLYDVFKNNLFKIFLNLRHLDIAALGLNDKTLRMLNEHGLWKSLVSLKVTLDASSSEELAQFLLRLLRNTPSLEELDISPYSESRHLSLTLDDFRILHTHLPHLKSIASKLSFKTISQDEVVSVPSTTPAPLVKSLELNSVDWENLWSYHTWMYYFSYKYPNLQYLTWKIGHEISTPLAQDYQEMNEEFLQLTPKVFSHLETVDFSAMYTSALSHAVFWDIVCLSRAPIKNIKYKIVNRIWEPMGLVEKIRQSAQSCKETLGTLFFDGHIDFEVRQVASLELPYCPRLVELEMNNCSVSIILDNLLNSCPMLRKLSISGGELGVSTDANAQISRHGLRLLKINEMVISITAFNYVSLRCRQLEYLYLTQSQVSGPFYSLARYTDSRTAINLVLLSHLIGPWQRSLSIQDINKRFIVYPIGWFRLFYGLDDMFDCTKTSRRLSEQEADFVENYYRGFFINRLIPEGEDSLVYSVLQYFEDDWAKDLYKGHIELRFDYVAEYFVPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AFH6</accession>
    <name>A0A163AFH6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_145548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291181.1">
        <property type="nucleotide sequence ID" value="XM_018431471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AFH6"/>
    <dbReference type="FunCoup" id="A0A163AFH6">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163AFH6"/>
    <dbReference type="GeneID" id="28992377"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145548"/>
    <dbReference type="InParanoid" id="A0A163AFH6"/>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052432">
        <property type="entry name" value="PITP/CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590:SF6">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN C365.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="176"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD73141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="446" mass="49583" checksum="DEC09953F9A87273" modified="2016-07-06" version="1">MAASPNNISLENRLEGYVGNLSAAQTTALKQLWIKLFALFKQEGQPYVVPTKPAQPETKATGGFFGFGAKVEPVQKDVFLGATTDEKWLTLPEEKAIELIPGSMLHKTFWNLVATDNPDASLCRFLRARKWDCEAAYKMLINTLRWRLVMRVDEIASLGESGLRDLLNKSLDGMGDSFIKQVHSGKATLGGPDKAGRVVCFINVQLHHKEEQSLEVVKLLTLYIMETSRLACGYPMNNAGLVFNLENFTLSNMDFEFVKFLLGCLEAYYPETLGSCYIHKAPWVFSTVWAMITPLLDPEVASKIVFTKDLEELTKYIDVSNLPVIITGNPNRKTKDESTKADPPAPGTLNPPQTPAVVAFLGALEKYEIVTKAWAETQTVENDTEDAIRRLENGRAYRVARIKAEKDLRGPTIYHAKGLVKVTDEGRLILDFGVDSSGQIDVTECV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AK98</accession>
    <name>A0A163AK98_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_187006</name>
        <name evidence="1" type="ORF">PHYBLDRAFT_189298</name>
        <name evidence="2" type="ORF">PHYBLDRAFT_73765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441002">
        <property type="protein sequence ID" value="OAD66612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD74061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD74071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284652.1">
        <property type="nucleotide sequence ID" value="XM_018439640.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292101.1">
        <property type="nucleotide sequence ID" value="XM_018442910.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292111.1">
        <property type="nucleotide sequence ID" value="XM_018439313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AK98"/>
    <dbReference type="GeneID" id="29000219"/>
    <dbReference type="GeneID" id="29000546"/>
    <dbReference type="GeneID" id="29003816"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_187006"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_189298"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73765"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD74071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="116" mass="13368" checksum="85BD174EC51CEC01" modified="2016-07-06" version="1">MFLFPSDASSSQWPSGLVKDISPKIFSTAKHDHQHDEQSSPKHAMDQKLLSHAAVIDMYYLYLQINPFDLGIQRNQNSVALLVIFYCLVFVLDNSNKIFHLKYNKPTEQEVARDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AM15</accession>
    <name>A0A163AM15_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carbohydrate-binding module family 13 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_186790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292461.1">
        <property type="nucleotide sequence ID" value="XM_018439284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AM15"/>
    <dbReference type="GeneID" id="29000190"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_186790"/>
    <dbReference type="InParanoid" id="A0A163AM15"/>
    <dbReference type="OrthoDB" id="2345540at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="360" mass="40201" checksum="222E448B01045F89" modified="2016-07-06" version="1">MVPTLTKLDGDWFYIRTVSNGNVASAGPIIAANDVETTRSEIRVEPPKYDDSELWCWKDRMLVNKSNGMVMSIRKGRLRLIEDTEICLYPKKSDEYISQQQWGVQHDDCPFGKRLEGCLLYSFHSNDWVFDIQTHVVNGDTKLILFPYKTIDNDTQRWELVSPADILQYSRPSSGSLSSSFSPVSLSSPTGFQSNSVSAFGSPTIGDLSPSTSSSSSQIMSQELNGSMEFACGLSPSKRGSQSSATGLPLETYRENHQAVYHGNGVPSSDKILAMAAAYQTWLDWSQDKQSQSSPTELQNQRARHEKTRARLQSMARTEVIKLVNANTTSTSNNHSAHRDNTISLTNRFITQLYEQMPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ATG6</accession>
    <name>A0A163ATG6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_64589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293721.1">
        <property type="nucleotide sequence ID" value="XM_018441318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ATG6"/>
    <dbReference type="GeneID" id="29002224"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64589"/>
    <dbReference type="InParanoid" id="A0A163ATG6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="123" mass="14141" checksum="B4EB3878BFC1834B" modified="2016-07-06" version="1">MYLYSKTTGIVLIILKNMFISSLCQVFSALIPAIKVCIPCLLPKGFKLYIASKNLRTDNRSTLGFHIPVVMMIHISTIDDIVPLLKMIYHKNCDDIGSIIYIFGTFDPDEITLFFQCKYKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B2F2</accession>
    <name>A0A163B2F2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_68594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295941.1">
        <property type="nucleotide sequence ID" value="XM_018441976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B2F2"/>
    <dbReference type="GeneID" id="29002882"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_68594"/>
    <dbReference type="InParanoid" id="A0A163B2F2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="104" mass="11827" checksum="F793C2C75FC33D3A" modified="2016-07-06" version="1">MYAYITEFAANINIKCQISLDTSQPNIVETLLIVLFSMLSSILCAKSNGTRYYGSEWGLLQRKAPKDKNKRSVSAHIKSFVKFTTKKNRSIKDIKEHKGSIEHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B684</accession>
    <name>A0A163B684_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Suppressor of white apricot N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_185225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296541.1">
        <property type="nucleotide sequence ID" value="XM_018439049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B684"/>
    <dbReference type="STRING" id="763407.A0A163B684"/>
    <dbReference type="GeneID" id="28999955"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_185225"/>
    <dbReference type="InParanoid" id="A0A163B684"/>
    <dbReference type="OrthoDB" id="10070965at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040397">
        <property type="entry name" value="SWAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019147">
        <property type="entry name" value="SWAP_N_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13161:SF4">
        <property type="entry name" value="CLK4-ASSOCIATING SERINE_ARGININE RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13161">
        <property type="entry name" value="SPLICING FACTOR SUPPRESSOR OF WHITE APRICOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09750">
        <property type="entry name" value="DRY_EERY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01141">
        <property type="entry name" value="DRY_EERY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Suppressor of white apricot N-terminal" evidence="4">
        <location>
            <begin position="39"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="289"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD78501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="526" mass="60172" checksum="B5AC6A6374B99D9A" modified="2016-07-06" version="1">MWHEARSNEKKIKELMVDHKKRAERRRAYYESRRGDPRQLLRVVGSAILLHPDAEQYYHHENTNNLMPWQGDPDIKIDRFDGRSLLEFVPDAKARDAKLQPTEDKELSDDLNFERYHDLVEAERLKVSEHDRLAEVEEEWNQLLDRHKALLAMLTEKKSDKPQGFGYDYGTNTTSDDMIIDQGPQLLKDILFFACVRACLFLQTDILKYVDELNDRDRQTLNDMAKKYGIRSYARLLRVAKKDRDDELRDLRSDSETSAEEDMSAPSDVVIEFGSETTPSNINMPAIASSRRTTEPTYHTNPEKTRVSEPANTRPEEKKLTPMEKLKLKMRAGLEKQIQLDQRDERRKRLEKEMEDYQAFTTYNGPMGPIVSQTNQPNLLSHHPVHKDIAPPAHHGHGHGPVRVRVHQQPRPIVSPQLNPWLLTLLIAATAADQIADQLPRKTATAVVVTIAVGPPSVVQKTVKDAVLQVILPPEQSALDADQLVQQTPIDHEAETGDLTDQGRQKNTAMSMVHDIEKLCMPSIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B9Q2</accession>
    <name>A0A163B9Q2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_62194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD79041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297081.1">
        <property type="nucleotide sequence ID" value="XM_018440926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B9Q2"/>
    <dbReference type="STRING" id="763407.A0A163B9Q2"/>
    <dbReference type="GeneID" id="29001832"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_62194"/>
    <dbReference type="InParanoid" id="A0A163B9Q2"/>
    <dbReference type="OrthoDB" id="2430203at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD79041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="26240" checksum="024E58B47BA5858D" modified="2016-07-06" version="1">MFMKRSRNKRLDKLIFIWIHDVEYYLTQEYERVMSNNGAMSSFTRQQRIREMEAEEVDDDARETMIVASVSAENSSWQVQSFVDENTAYVVEVTDRLIMKYTCFDFERRQKPCKHMYLLKMHTAFSLHFSTTPLNPTYEHNVIPIPQPIITNNCSSLFFNQCIQTNQTLHQSHQDLATLAHDLVNYESSYFLVSILGDGGFLAMGMGGNGTTQFKVTASPRPGYKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BAT7</accession>
    <name>A0A163BAT7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="2 7">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_129877</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-formylglutathione + H2O = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the esterase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="2 7"/>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297351.1">
        <property type="nucleotide sequence ID" value="XM_018429315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BAT7"/>
    <dbReference type="STRING" id="763407.A0A163BAT7"/>
    <dbReference type="GeneID" id="28990221"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_129877"/>
    <dbReference type="InParanoid" id="A0A163BAT7"/>
    <dbReference type="OrthoDB" id="420518at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000002">
        <property type="entry name" value="S-formylglutathione hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD79311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="282" mass="31181" checksum="D10C4574B64738CD" modified="2016-07-06" version="1">MSLKEISRNKAFGGQVIKYEHHSNELDCDIKFNVYLPKEADSAPVPAIYFLSGLTCNEDNFIQKSGALVEAAKHGIALIAPDTSPRGVSIQGDSDSWDFGTGAGFYVDATEPSWAKHYRMYSYVVHELPALINKSLPIDGSKVSIMGHSMGGHGALTIFLKNSANYQSVSAFSPIANPINCQWGQKAFTGYLGKNQETWKEYDTVELLKKFNGKVNALVDVGTSDNFLENQLNIDTLKDTVGSLGKSSEWTIRYQPGYDHSYFFISTFIADHIIHHAKALKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BES2</accession>
    <name>A0A163BES2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_138670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299161.1">
        <property type="nucleotide sequence ID" value="XM_018430046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BES2"/>
    <dbReference type="GeneID" id="28990952"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138670"/>
    <dbReference type="InParanoid" id="A0A163BES2"/>
    <dbReference type="OrthoDB" id="2253354at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035213">
        <property type="entry name" value="DUF5321"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17254">
        <property type="entry name" value="DUF5321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD81121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="198" mass="22695" checksum="4A76F61D22F904DD" modified="2016-07-06" version="1">MSFIPRVGISIATKACLNPGPLARPLIRRAFLTPVRTMSTPTAASASRDQQNNLRVAASHFKRQRHLPYFLEYLMWVVFGSEALHLIWLKMEYKEYKEKVEHKIQLLQEIVTRIEQGQEFTDSLREEIKMVLLNNKQASATNDVDIDDAYLEKLIASSEKQSVAEDGAEFNGPVEEKRSTRWVESTETIDGKKKPVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163CT92</accession>
    <name>A0A163CT92_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_176049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441010">
        <property type="protein sequence ID" value="OAD65450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283490.1">
        <property type="nucleotide sequence ID" value="XM_018437633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163CT92"/>
    <dbReference type="GeneID" id="28998539"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176049"/>
    <dbReference type="InParanoid" id="A0A163CT92"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="36358" checksum="5CA664720116EBA4" modified="2016-07-06" version="1">MTNTRRERAIALRPVEITNQQLMEILSTVRADMSTVKGQIGNVEQTLTNMNGRIGVLATTSTNTISAIDSLARTPLAAPVRAELTVAAPVVISNHEPTREESNAVYAHIHNLMWKPKLSLRTPENILANNLKPRWDTNVAFNKSPNREIAERLLSNLERRFGSSSMRRSDLRKRLHTNFTSRTRRERMSDDEIAETNALTRRAARADDNECRRVLAYKDNKEAIDLVMLRDCANTLQKAVMSDGESADEMDEDGIKHVIHIVQPGWRSDECNRFIALVDTYAVQAMGSSANQRIRRITTSVSNSAVPDNISPNFPRWALRDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163D0E4</accession>
    <name>A0A163D0E4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_150899</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285850.1">
        <property type="nucleotide sequence ID" value="XM_018432568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163D0E4"/>
    <dbReference type="STRING" id="763407.A0A163D0E4"/>
    <dbReference type="GeneID" id="28993474"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150899"/>
    <dbReference type="InParanoid" id="A0A163D0E4"/>
    <dbReference type="OrthoDB" id="547311at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070552">
        <property type="term" value="C:BRISC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045739">
        <property type="term" value="P:positive regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21502">
        <property type="entry name" value="vWA_BABAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026126">
        <property type="entry name" value="BABAM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15660">
        <property type="entry name" value="BRISC AND BRCA1-A COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15660:SF1">
        <property type="entry name" value="BRISC AND BRCA1-A COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD67810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="172" mass="20245" checksum="3CD631628B2A8D3A" modified="2016-07-06" version="1">MKDKAEMNMFFEDDQLLISEAIERLEATHYYDKFDTESLFNLIERNVDLSDKSLFTQVIVLYGRSETIPSLVEEDTYNRVRCSPNLTMDFVYIHQSPKHIPRCQQVFNFWCSLDSTKVKGWYYEFGHLGKSSFTRAMVQLIAHPLQRGDQMKMKMPIVSFYGDHSSVFDIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163D950</accession>
    <name>A0A163D950_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_159822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287700.1">
        <property type="nucleotide sequence ID" value="XM_018434066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163D950"/>
    <dbReference type="STRING" id="763407.A0A163D950"/>
    <dbReference type="GeneID" id="28994972"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159822"/>
    <dbReference type="InParanoid" id="A0A163D950"/>
    <dbReference type="OrthoDB" id="2275777at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="145" mass="16479" checksum="E2787A708EA938DA" modified="2016-07-06" version="1">MELYGLCLRISALVRFYSFSRRTSIIIHRAKKQKDADKSNEERLISLAKDQEKAYGTLRECEKYLGYHHIIQKFPVTFDDVCTKGKLGAGIVLGGEAGVSIEPMFPFAPFSRLHHAAIMGKCIIGEFVTQRELEYNPISNTDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DKW8</accession>
    <name>A0A163DKW8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ISXO2-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_169919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290050.1">
        <property type="nucleotide sequence ID" value="XM_018436211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DKW8"/>
    <dbReference type="GeneID" id="28997117"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169919"/>
    <dbReference type="InParanoid" id="A0A163DKW8"/>
    <dbReference type="OrthoDB" id="5598606at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053164">
        <property type="entry name" value="IS1016-like_transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163">
        <property type="entry name" value="DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163:SF2">
        <property type="entry name" value="SI:DKEY-17M8.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ISXO2-like transposase" evidence="1">
        <location>
            <begin position="137"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="234" mass="26768" checksum="F577482D8FD2ACA0" modified="2016-07-06" version="1">MALTYTSEFAKQYLIAQSALYPQNHIIFTCSGGSSMDYIFEKDRGYSYRCSGVNNMGATCCKRERKSERLDSFFAQRHLSYNVVMQGIYYWLNWIPRMTMGVMLGVSPETIRHLIASIHQLIQMDLTNNDMRIRGIDANGQSIIVEIDESKFGKRKYHQGHRVEVPQRDAATLLQVIKKHVKPNSIIHTDCWAAYGGLTSVVDMNYTHRTVNHNVEYVTSDGIHTNTIEVCGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DN30</accession>
    <name>A0A163DN30_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_65477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290520.1">
        <property type="nucleotide sequence ID" value="XM_018441470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DN30"/>
    <dbReference type="GeneID" id="29002376"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65477"/>
    <dbReference type="InParanoid" id="A0A163DN30"/>
    <dbReference type="OrthoDB" id="2269543at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="49463" checksum="F64577FAAD2EED4C" modified="2016-07-06" version="1">MLASELPFEILSLVRDFLLTCERFQCIFVCKRWKVPFQESFWKNTEVDTFVNLRIETSKLNVPTPILIKLLTNYPSLKKINVSTHSSTKLLNFNLRNFNTLHKRSLQLEYIKGCFSLTDIHQNLIKTIPSTTPALHVTTLDLDLLDWDHLWLYYFSYKYLNLPTLKWKTICAPRKRIVKKYNAEKMVLLNSLQSVFPHLEMSFSTTLKKISIIRDAYFKAKNIVRSEFPYCLRLTSIELTDCGISITLDNILDNCPALRQLKFSRGQLTTSPEAHKESNTEIYNINLSHSQIGGLISAKIGSLCIDMSYTSFKLLQLSHVKFYSSENAMDKDTAINLTLLSHLTGLDMTAETEDLNKALEHSVENLARYHLYCELEGLFDFTLERSRVKNMSQSSEADRSFDGQVSQNDWKEDLYRGYVELRCGHAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DUY6</accession>
    <name>A0A163DUY6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_181278</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291630.1">
        <property type="nucleotide sequence ID" value="XM_018438443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DUY6"/>
    <dbReference type="FunCoup" id="A0A163DUY6">
        <property type="interactions" value="243"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163DUY6"/>
    <dbReference type="GeneID" id="28999349"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_181278"/>
    <dbReference type="InParanoid" id="A0A163DUY6"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="45"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD73590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="260" mass="29833" checksum="E9A9DB13C4EF2A37" modified="2016-07-06" version="1">MKTVHQTAAEGFKPAAESYAKTRPHYPDSLLEHFLQIVPTGSNVVDLAAGTGIMTEPLVKAGYRVTPVEPVEAMRQELERQVGIPALEGTSWKIPVDDGSQDAVMVAQAFHWFDDIETLREIHRVLKPGGVFALTWNMESKERSDWVAAIRRIYEVYDEAAPQYRKGHWKKVFETDEANQLFDLPLKHIRFTNDFEVPTSHVFERVLTKSYIATLSDQQKQQLRRDIEAQLVPEKGFVPNNDRMILYPHDTDLSWCLKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ELK7</accession>
    <name>A0A163ELK7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_58379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297370.1">
        <property type="nucleotide sequence ID" value="XM_018440306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ELK7"/>
    <dbReference type="STRING" id="763407.A0A163ELK7"/>
    <dbReference type="GeneID" id="29001212"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_58379"/>
    <dbReference type="InParanoid" id="A0A163ELK7"/>
    <dbReference type="OrthoDB" id="2428624at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD79330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="174" mass="20359" checksum="D906128D500A324C" modified="2016-07-06" version="1">MTLRLENIIRVKTSEWKECLTEIGEACAVKWVIHNTNKQPTNITAEEAKATGIKLCFSQEYFCHRWGTYESKVALHVVQKQTKKNKCPALLRVKGFFKTPEFYEFVVTKDHAEHTPGDMRSDICTLPLAKKYLHELAQQLEQSLFMHDSDYISYDDITIIWDTSVDYYKHNYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ETD8</accession>
    <name>A0A163ETD8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_139002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299490.1">
        <property type="nucleotide sequence ID" value="XM_018430127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ETD8"/>
    <dbReference type="STRING" id="763407.A0A163ETD8"/>
    <dbReference type="GeneID" id="28991033"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139002"/>
    <dbReference type="InParanoid" id="A0A163ETD8"/>
    <dbReference type="OrthoDB" id="5555696at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="49"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD81450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="318" mass="35409" checksum="2553391A7B08C498" modified="2016-07-06" version="1">MPNQECEFELPWIIYPIIFCVCLLGVLCFIRMHIPLPFFLRHFQDLDRWPLDEEEYQQINQPRYNSIHGYMSKGMSPLQLVSILHRGVYAYEFKQEPDSGHAVNNRTQLSFFSGESSLQTNIGLPTNQAVCYWEATLTKVSPTTFVSVGIATKPYAGWRSPVTINQCGNTGRFETNPHSYVYSPMGGSMYGSEFMHGDVIGIGYSASHGRVFFTFNGTLLDVVCDGIQWDMFPTIDVRGTAEISVNLGQSVYRYPKANTLPWGLAGASASVTSVFSEPPPPYGTQKESVLLAFGPNSQPRDGSVNMDSLNQVVIQPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167J2W8</accession>
    <name>A0A167J2W8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_176474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441050">
        <property type="protein sequence ID" value="OAD65038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283078.1">
        <property type="nucleotide sequence ID" value="XM_018437789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167J2W8"/>
    <dbReference type="GeneID" id="28998695"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176474"/>
    <dbReference type="InParanoid" id="A0A167J2W8"/>
    <dbReference type="OrthoDB" id="2214613at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026960">
        <property type="entry name" value="RVT-Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13966">
        <property type="entry name" value="zf-RVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase zinc-binding" evidence="1">
        <location>
            <begin position="293"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="448" mass="50654" checksum="36200E8A0DD27797" modified="2016-07-06" version="1" fragment="single">LNSLILSKLWHVLRVVTVPLSFFRRLRSIMSKFIQYRSFPPISLGTFCQPIRLGGLGVLDPQVQQAALQLRWLRPLVRSPLSPSGLVPPWFSYVLRLDSSSADPLVPLIFPSLRSSHQRDFDSPLATLLAAIDLLPHNFSDVVVNLPTCLSLPLSYLTTAQPDHPPFPSAWRDLRVSDAYEVDPSFGVLAQRPLHRILRRPIVLHRFFERLYTRSLVLHPVLYRATIPPAICAIQFPSLDMPSGTAVDVRPFLTALVPGIPWHRLSTQSFRLLCNFHSKSARPISPTLVPRQLRRFWSFPLPHGARNVWFRALHKNIPCRSRLNSRIPTAFPDPSCALCSHPLDNQTHFLFQCPVKLSVWSSIWTLYFAQTATPTVLLSGLQSFTFPPCTDSSLFAASIFGCTLLAIWRHHWLFIFDHVPFVSSAAFSTASSLLDRLKSELALDFPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JCK2</accession>
    <name>A0A167JCK2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_175893</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441008">
        <property type="protein sequence ID" value="OAD65718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283758.1">
        <property type="nucleotide sequence ID" value="XM_018437601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JCK2"/>
    <dbReference type="STRING" id="763407.A0A167JCK2"/>
    <dbReference type="GeneID" id="28998507"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175893"/>
    <dbReference type="InParanoid" id="A0A167JCK2"/>
    <dbReference type="OrthoDB" id="410920at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="61"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="219"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="474"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="491"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="525"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD65718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="586" mass="64083" checksum="388CE249FE21CB8E" modified="2016-07-06" version="1">MKVPALVPHVFTTKPSWWKRFSKNVHTKPNNPNQHDWRTLSPNQPPLPKLATPNTTPNTTTNTNRRLSKGFFSNDIQYHTFDPISLSLSSTSSSNSTSFQQTPTNTYVIRRLYPILEADEEFMSTSIESSSISLPPPLPLHSETIDNQLTKILQASPPLDSQTSSPLSPSPSSSPRSLSPQPPIQLIQSIQSIQSVSPLSPPQPPPHHNIPLSISSASSLSSSSYSPPVQWPTQQKCEPQFNPSSVNNEDQCKRKFVKMIQAAYEYHETNHQPPTEIEIIFNSKDDVNHIRLFHYINGQKADFHVFCGYGLYSDRNPQYIPPEASLGATYRNGLADVWVLGISLYRMLVGKYPFTATTDRKLFKKMLQGDFSIPTHLSQDVKDLLRRMLAPDATRASLDLVVFHPWLKPYSVVVPDLPVESPSRFAAVKPSSSSLSTAPPAAVIAAAGVSSASASASASASASASASASASASASTAASPQSKSKSKLKLKPSTSTPTSTATPRHIQTSNSPSSTSSSTSNPNKAKSKNKNKKKKKPKRLLRKFLLLVLQGPCPPPKQPYRDLANFGRMPTENNGLNQTNTKLTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JKL7</accession>
    <name>A0A167JKL7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_175490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441005">
        <property type="protein sequence ID" value="OAD66196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284236.1">
        <property type="nucleotide sequence ID" value="XM_018437501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JKL7"/>
    <dbReference type="GeneID" id="28998407"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175490"/>
    <dbReference type="InParanoid" id="A0A167JKL7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="100" mass="11056" checksum="1CE4AE7050BE7EE4" modified="2016-07-06" version="1">MSDINTTLINSVKKIGINIAKYTTSFLVGFERVAKSVKKSQFTEYPDQLGKQVQQDANDFSLSSNNISESNGGKPPIIVNVLSSLAEMSVEPAHQRRQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JNU1</accession>
    <name>A0A167JNU1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_152463</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441003">
        <property type="protein sequence ID" value="OAD66388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284428.1">
        <property type="nucleotide sequence ID" value="XM_018432922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JNU1"/>
    <dbReference type="STRING" id="763407.A0A167JNU1"/>
    <dbReference type="GeneID" id="28993828"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152463"/>
    <dbReference type="InParanoid" id="A0A167JNU1"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="48"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD66388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="491" mass="54150" checksum="1D0D5BE3177D6064" modified="2016-07-06" version="1">MSQRSKQNSTPLGPITDFEGNSKVYTTEELSNRQIQEKHILRALDLHTMPLFCIFYFTDHLDRANIGNAMLGGIHKDLNIAPSQLSIVISAFYITYILFEVPSNIMLTRTSPVLWLSLIMAVWGTVTLTMAFSSNFEGLLTCRLLLGAAESGYIPGILYQMSCVYKPRELSLRIGCLFCMASLSGIVSGPLAYATSFLDGKRGLHGWQYLFIIEGVPTILLSVISYICLFDTIDSVSWLTDEQKEIQHLRLAEGKSDADNRQEPITFKTLWLVLTDWKMWMFSMVYILSAINITSIGVFIPTIIDGFGFPVLTSQLLTAPPALVSTFMVILGGALADRCKARAPLVMAGFVLIGIGYLLLLTLHNTWALYGSLFIIPAGIGLQAPAVVGWSSINFPDITTRAVAVAAVVMIGNGGSIVASFLYPLVDAPHYHFGNSFNLVVSVLGCLFSGLTGYLLYRENCRRDRVTSIANDSGLSLEEEKATALQFRFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JRG8</accession>
    <name>A0A167JRG8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_152360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441002">
        <property type="protein sequence ID" value="OAD66559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284599.1">
        <property type="nucleotide sequence ID" value="XM_018432892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JRG8"/>
    <dbReference type="FunCoup" id="A0A167JRG8">
        <property type="interactions" value="318"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167JRG8"/>
    <dbReference type="GeneID" id="28993798"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152360"/>
    <dbReference type="InParanoid" id="A0A167JRG8"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000153">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="14"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="333"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD66559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="367" mass="41619" checksum="8218B573E5592019" modified="2016-07-06" version="1">MSGQRAPVTVPCKYKTGKVLGNGTYATVKEAMHIDTNKFYAVKIINKKLMEGREHMIRNEINILRRISENHNNILSLVDYFETLNNLYIVTDLASGGELFDRICQKGSYFECDAANIVQTVCDAAAYLHDNGIVHRDLKPENLLFRTTDEDADLLIADFGLSRIMDTEKFHMLTTTCGTPGYMASTRDLQKDWSRETSQKKVTDRDFYTSDMWAIGVITYFLLCGCTPFERDNNIDEMNAIMHADYTFDEQWWSGISEEAKDFIRRCLTIDPAKRMTAHEALQHPWLASTHISKTEKVAQDLLPSVRGNFNARRTFKKAIDIVRLSYHIGHKHSASTGSASNSDDEEGNGGVVKPVNENPNQVLKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JVN8</accession>
    <name>A0A167JVN8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_152046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441000">
        <property type="protein sequence ID" value="OAD66779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284819.1">
        <property type="nucleotide sequence ID" value="XM_018432826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JVN8"/>
    <dbReference type="GeneID" id="28993732"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152046"/>
    <dbReference type="InParanoid" id="A0A167JVN8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="259" mass="29653" checksum="99EE2973FCE5E464" modified="2016-07-06" version="1">MSDINTTLLNSIQKIEVDLAEIKQALRELQRQFSNQFAPAVSVEDLTTMQQSIIEQSSLERIAESLGKRVINTGGKFKGKNEAQKYNLLLQILHEQDWKARCKEVPQGQPLPPLVPLSDHDLTVKRLHLKTLGHTVKHDIIDKYYPAASKEWKNIPEKNRDYYMMHLERLAKNGGLHIHQCKRMWCVRSLLQESFKSDNQMHKRRMAEKNKTKRNISDSSLSSLDMSETGDVESPIMADVLSPPPTASVKPACKRSRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JWQ4</accession>
    <name>A0A167JWQ4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_174850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441000">
        <property type="protein sequence ID" value="OAD66826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284866.1">
        <property type="nucleotide sequence ID" value="XM_018437359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JWQ4"/>
    <dbReference type="GeneID" id="28998265"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174850"/>
    <dbReference type="InParanoid" id="A0A167JWQ4"/>
    <dbReference type="OrthoDB" id="2267579at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="413" mass="47399" checksum="E76F5F1983E6DD5D" modified="2016-07-06" version="1">MNPVKKTVQKLLELYKKLKSDSLTTDRSELIELPKEIHDDMENTLSISLKQNLKRFAKDTLQYHGAIHKGAERIRTTTKATIEIYQNLGYLIETGGSPEEVHATMEKARRLAIYTYAMGKGLDGDTKDIADKAIHLPDAIRYLNENEEAEGKDLAYSPETLERIQEARYEDAILQKATDSPCAYNQNCGQYPGRGGRGQRTYQGRGYTHNTNNHGGLFWERTTKRTRSTNDVSNKSTSSQQFSPSSLELLKHPSLTIEKISKTIQLKNGSLLSDNTMKKSLENKKKRQYSTLQYPCRLDCTCEQTPKVPPQLNNTHESPMAVLHYQPRVPNTIPIPTNSLEDQQAFQTLRDRPASSEQECRKMLRIQFRDSSSKVYDQVWNKFSEWCQKMDPTLNIEDYNPTLMVEYLVLNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JZD6</accession>
    <name>A0A167JZD6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_174678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD66970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285010.1">
        <property type="nucleotide sequence ID" value="XM_018437309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JZD6"/>
    <dbReference type="GeneID" id="28998215"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174678"/>
    <dbReference type="InParanoid" id="A0A167JZD6"/>
    <dbReference type="OrthoDB" id="2441661at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="30937" checksum="A58C0FD95A2E9409" modified="2016-07-06" version="1">MHDKENWVNTYVFKHSHFGNRTSNHAESSYASLKHALGTSSGKLKTVTMKVVKWYEALIDDRKCRLTMECLGESNTVVFDKINSSRLNDIRHKVCRFAMDHIKLELAKSIIPEKLTKECECLINYNYLLPCYHQLAQYKKIPISCIPRQWRINYLEGEDHSILHNALSVPKNTTKITTITSQLAYKLERITQILINAQNKQQQIYFEEYIDKIIELDSKQKLENLNDPTVVEAIKGRPKNTKRKMIALEHCLEAEKEETIKKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K2R0</accession>
    <name>A0A167K2R0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_67273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441025">
        <property type="protein sequence ID" value="OAD67140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285180.1">
        <property type="nucleotide sequence ID" value="XM_018441768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K2R0"/>
    <dbReference type="GeneID" id="29002674"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_67273"/>
    <dbReference type="InParanoid" id="A0A167K2R0"/>
    <dbReference type="OrthoDB" id="2289822at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="283" mass="32325" checksum="4429714C843593D1" modified="2016-07-06" version="1">MISAQSSTFLVHLIQMKLPYFSSDIPYIIKQQGPLRCYFTCSMESIINIFLELIKSKSKGGQNASFLIKRFAINNYTSTAISICDEINLIWPKPYGRESYMDLPNDSSSAHLWELFHQFVNLNDDLVEGVGGPSVKEALLKYYQRTTGLTGHEFGDSVIVVAASLWIDSTVYISWMYQRKKNKTSRGNHYVMFTCPYRNNHNVIVHSWLVGTIQFYFQHVDFHGFPHFLAFMEVMKEHDAAGHNSSVPIVKQWSQSTHTLGHQTQPTYAVISVNDICHQVGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K654</accession>
    <name>A0A167K654_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_136983</name>
        <name evidence="5" type="ORF">PHYBLDRAFT_137361</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441004">
        <property type="protein sequence ID" value="OAD66286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284326.1">
        <property type="nucleotide sequence ID" value="XM_018429852.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285390.1">
        <property type="nucleotide sequence ID" value="XM_018429823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K654"/>
    <dbReference type="FunCoup" id="A0A167K654">
        <property type="interactions" value="506"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167K654"/>
    <dbReference type="GeneID" id="28990729"/>
    <dbReference type="GeneID" id="28990758"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_136983"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_137361"/>
    <dbReference type="OrthoDB" id="2449818at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000006">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000002">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000009">
        <property type="entry name" value="Ribosomal protein L10a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD66286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD67350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="216" mass="24120" checksum="9097540F3C563855" modified="2016-07-06" version="1">MSKVSGSAVRETVRAIKAGCEEKKRNFTETIELQIGLKNYDPQRDKRFSGSIKLPNIPRPNLSVCVLGDAFHCDQAKAAGMEFQSVDDLKKLNKNKKQIKKLAKKYDAFVASEALIKQIPRLLGPGLHKVGKFPTPVSHADSLTDKANEIRATIKFQLKKVLCLGVAVGHVQMTEDELLANIMLSINFLVSLLKKNWQNVKSLYLKSSMGKPQRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K8U0</accession>
    <name>A0A167K8U0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_136829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285537.1">
        <property type="nucleotide sequence ID" value="XM_018429814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K8U0"/>
    <dbReference type="STRING" id="763407.A0A167K8U0"/>
    <dbReference type="GeneID" id="28990720"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_136829"/>
    <dbReference type="InParanoid" id="A0A167K8U0"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF11">
        <property type="entry name" value="LD23561P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="375" mass="42357" checksum="B251561A0619214F" modified="2016-07-06" version="1">MTVSNSNCSVLVLGGVGFIGRHFVHHLVQNGLASYIRVVDKALPQTTYLSESHKASFEKVEFKQSNLIHPAAIATCFEREDGSSFDYVFNFAGETKYSQVAEVYQERIFHLSVNCAKEAAKRKVKVFVELSTAEIYDSDNSASSETSKIKPWTIIAKNKYKAEEELKKIPGLNLVILRPVVVYGPDALLGLTPRLIIGRIYQHLNEEMKLLWSKDVKLNTVHVDDVARACWHVATWYETRKTTGVPIFNLADKEDTDQETINRHLRSLFGIQTGYYGSVVSSFAKLNLDYVMEDVNEKHLAPWADLLKSSDIRVTPLSPYLDEELLYNNALSVDGTKIERETNFSYTVPTLTQAKLREIIDGYKALKVWPTDVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KG88</accession>
    <name>A0A167KG88_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar protein sorting-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_57710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286066.1">
        <property type="nucleotide sequence ID" value="XM_018440246.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A167KG88">
        <property type="interactions" value="285"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167KG88"/>
    <dbReference type="GeneID" id="29001152"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_57710"/>
    <dbReference type="InParanoid" id="A0A167KG88"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056748">
        <property type="entry name" value="VPS13-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056747">
        <property type="entry name" value="VPS13-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25037">
        <property type="entry name" value="VPS13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25033">
        <property type="entry name" value="VPS13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="VPS13-like middle region" evidence="6">
        <location>
            <begin position="1180"/>
            <end position="1867"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="7">
        <location>
            <begin position="1922"/>
            <end position="2499"/>
        </location>
    </feature>
    <feature type="domain" description="Intermembrane lipid transfer protein VPS13-like C-terminal" evidence="8">
        <location>
            <begin position="3038"/>
            <end position="3143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1035"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1395"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2562"/>
            <end position="2587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1035"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1395"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2569"/>
            <end position="2585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD68026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3169" mass="359853" checksum="C32B88CB36EE33D2" modified="2016-07-06" version="1">MLESVVSTLLNKVLGAYVSNLNYNQLQIGIWSGEVVLRNLRLKREALDKLNLPVDVLHGYLGELTLTIPWSNLKGKPVMININDVYVLAVPRNESTMTADEIKARQHEAKMRKLADAEMIHQPVEHTNAAEDAKNETFANQLMQKILNNLQFSITNIHIRYEDEVSAPGHRFAAGITLNELSAISTDENWIPQTIGDAVNTIHKLATLESLSVYWNTDTYSLSHLKDDESFTRFRSLIATKTHVPPEHQYILKPVCGTGRVKLNKKFGGETPKVDSTLLFDELSFVIDDEQYRDAILMIDLFHSYLKKQKYQKLHPPSTVTPRTDPRAYFQFAANAVLSEIHERNQRWTWAHIKQRRQDRLDYIDCYVADKLGQPTPEQKQKLGELEHKLSYEDIRLYRGRSKAHLRREKERLAAEEERKRKAAAAQAANSKGWLGSWWSTPNTANQQEEDEDLVITEEQKQEFYDAIEYDEDMAAVVESIEFPKDTMLLCLRTTLNKGSFTLKREPHANNPLELVSLVFDTVMLGAIQYVDSFKITAALGDLILYDGATKNTQYKKLIGVKQKEPKDRRKSQLDKHLIKFENMKNPFFSLAIEHKPLDGRADNAMALVMRNIDIVYNPITISAVIEFFRPPETSADSVNALIEVAGDTLEDIKNQTRASLAFALERHTTLDLRVDMDAPVIIIPENCSLKNCRGIVVDAGHINIESNLAPAGAFNEMKSKKSAEYTTEDYVQLRSFMYDKFTIQLTQTKILVGDSVDTCLAQVREPTKEYNHLHLVDRIDMTFLLEMCIVAKSNDLTRFKMSGHLPLLSVNFSDTKYRILMQLPRLIEASGILGNDKPDHLESDEEDSDELWSVAETAETEATQLKQKTSKETHVNQKIFELDFKVDKVSANVLMARRQREEGSTFEDLLCEVTLEHLSVEYCMRPFDMSIGLSLESLNVVDRMAHGNEFKYLVTSDNMVVPSSDSKSKSEPTELVHVEYIRVDKESPEYRNKYKGIEQTANVTLSTLNFIVTQSSVLTLYSFVLDTFVEDESPTRTQDRRVSRQQDKRLSVSKDADQRRRSSAVPPKDSTPPQPSNIYVHLLLDSVNFILNDDGVRLATGRLSHGDMSVLMIQNTVKLSAKFDNFTLTDDLNDTSEGSKNTHQTDLLTIQGEELIDLRFESFIENGPQIYPGYDQLLYLRMGSAQFTFLEQPITRFMSYFSKFAEMKLMFDRARQAAYESAQHLQQAVTKMHFDVVIKTPVVFFPEMHNHPMDVVVAHLGEIWASNTFVDEEDGCINAIRAGLRAINVTSTFHAIHPSTKKIQVQELPIVENTNLTLDIKSPQQINTLRPDMDISGKLSDLSMRLTEVQYIFLMDAVNMISRIFSGTEEPDSSSKTHPNQSNLLTQEDQLQATTDENTNINSRTNVSSDVDEENHEEPPRIRMDLDAQTIALELFTNKDVNNWTQPPDSLLKVAMNGSRVQVEMLKTGCIKTDLKVKSLVVNDSRPNINSKYKEIMPAIENGYQFEMLLDLSPADPVRRGVAIMTINDPKVIISLDHAFVLQNFAMLPFTQNHNPASSHQSSAKHTEEFLSGLAENLAAEPVVEQGIELSYSLNVVRAEFVLLANPDTIESEAVVLSAEQVMISRQAVTALVVRQMGMFLCRMDKRNVSTLKFIQTFDVSISMNIDTKGPEGQPKTDLQVDVDALVLRLSYRDAMLITDIFNKAYALYEKSVGSQPPALSGTSPAQTTVSTNNTPHAHELPRFMEAKESLRASFQGMQVILIDEIHEMPMVDMTLKPFSVDVANWSRSLSATVELATYINYFNIKNSHWEPLVEPWNVQLAISRNNMLPNDPLHVELLSDNILNLNVTHTFLESAMATMHLWDKRSYNGYHGERGAVAPYRIANHTGYKVHVWSTKVGDKKDTVIKSLENGQEMEWWFEDWRKRRETTSSGNKNLLNVQLEGALWESLRDISVDTEGEKMQPLQPMINDVEHHIMFDIKLVNNVKVVTIRSTMVIENKTLLPVDFVLLDKSGNPCSHIKKIAPGQDYAIPIEAAYNDRFCVRPDAGFGYKWADKMLHWTDFVRPGEKPSTIQCLGEGEDMPPFMFQIHSRFDKNNQLFGHYPVMSIRLSAPVEIENLLPFDFNFRIIDKTAKQDFGSFLRKGGVAPLHVIKNKHLLILNIAILDSNYNPSDFAIISTRGTEDLNIEDTLQLKSKDNVLLTLKINTMDIPDSGGARKYSIYCPYIVINKTGCPIGFKPKLAWQSSMFSGAQNTAVCRPGVKPEPFMFSYPKIDNRNRCLIQISGSEWSIPISFEAVGTMYDVTVPSPSKTEEIHVGVSVQEGQGKYKISKVITFTPRFILSNQMDEFIRYREPESRVDQDLEPNQRIPLYNLRRNAEKQLSIKLPGINNRWSAPFNIQDIGKMHVRLDSADGSTAMLMRVTTILQDATVFIVLSKEDSKNWPFRIVNETDDTMTFYQEELSIMRDDFSDNRMHQQSARRYRLPPHQSVPYSWDMPANKDKKIILNIYGRERSINLQEIGSQLPFRYTTREGKPAIASIDIKISDMVQYVYLKPFVQSESLFRPTSQGSNSSVTSLSPSTSTSTSFKDTNVREGFEAVEMNLILNLIFKIEIKQIGLSFINRRLDEIAYITLRGLNVSFKDSNVYQSLRWSIKWIQIDNQLPGSAFPILLYPTNVTREGNHEILPTLQLAVDRVKDDSHGVLYIKYFSVLLQKMSVEMDEAFVYSILDFSHINVEGWNSVVDDGKLWEYTNEIPDVNLEDGVAQLYFEMLSIQPIRFDLSFLRTDQLNIVDERPQGNSPLMFFVNILTMAIGNINAAPMKFNALAVENLRASGSDLSNRIFIHYSDQFIYQIHNVLGSADFLGNPVGLFNNLSSGVAELFYEPWQGFIMSDRPQDLGLGIARGFSGFVRKSVFGVTDSFTKFTGSIGKGLSVATMDRQYQDKRRQNMARNKPRHALVGVAQGANYFANSIASGMTGLVTRPIEGASKEGVSGFFTGFGKGLVGAVTKPVVGAFDLASNVTEGIRNSATPTDVNDIERIRYPRYIGNDGILKPYSTKEAQGQHWLREVDNGKYFQDSYIYHCHVQSDERVAMLTSNRVMLLRTRRLMVEWQEPFTEIDTIKCQSTGIAIKLVNDKWEPFLVIPDKKTRELLFRKIEEAVLKYNNVRRPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KGI4</accession>
    <name>A0A167KGI4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_173541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286085.1">
        <property type="nucleotide sequence ID" value="XM_018437054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KGI4"/>
    <dbReference type="GeneID" id="28997960"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_173541"/>
    <dbReference type="InParanoid" id="A0A167KGI4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="135" mass="15569" checksum="00A001CB4B6308CF" modified="2016-07-06" version="1">MANILNLDTQNTILPIHIVFFYWYGFCVLDLRLGGILTLSMYQKTWLIIPTEHPSKSWFIFLKCFVVNRMMNSKGFNLDPGFGYTSHHIVAWKQPSILFTLPCLDAEEGSSPSFKCRFLGLFPILRPMKAITSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KHG8</accession>
    <name>A0A167KHG8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_160235</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286147.1">
        <property type="nucleotide sequence ID" value="XM_018434144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KHG8"/>
    <dbReference type="STRING" id="763407.A0A167KHG8"/>
    <dbReference type="GeneID" id="28995050"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160235"/>
    <dbReference type="InParanoid" id="A0A167KHG8"/>
    <dbReference type="OrthoDB" id="273181at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052103">
        <property type="entry name" value="Dual_spec_Phospatases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45961">
        <property type="entry name" value="IP21249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45961:SF6">
        <property type="entry name" value="IP21249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007889421" description="Tyrosine specific protein phosphatases domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="26"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD68107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="129" mass="14563" checksum="BCEC32A06D977EF5" modified="2016-07-06" version="1">MYVLVYVCLYVCVAGSLDSAKDHHEPIYVHCKAGKSRSAAAILAYLVLSEQWTLKRAYRHLIKSRPTVSPNIGFVAELMKLEESVHGQVSNFAGTDWHLIDTTHPPSPDSQREIGKLQKAWREQSNRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KYG7</accession>
    <name>A0A167KYG7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_149581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287216.1">
        <property type="nucleotide sequence ID" value="XM_018432300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KYG7"/>
    <dbReference type="FunCoup" id="A0A167KYG7">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167KYG7"/>
    <dbReference type="GeneID" id="28993206"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149581"/>
    <dbReference type="InParanoid" id="A0A167KYG7"/>
    <dbReference type="OrthoDB" id="24745at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030681">
        <property type="term" value="C:multimeric ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="entry name" value="Ribonuclease P, Pop5 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441:SF2">
        <property type="entry name" value="RIBONUCLEASE P_MRP PROTEIN SUBUNIT POP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD69176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="159" mass="18475" checksum="C8E54A34873AAD50" modified="2016-07-06" version="1">MVRVKSRWLLFEIVEDPFIQDSKVVFPHTPFNITEEHLTRIIRETITIHHGDFGSGMAWNTSVKWFNSTTRTGIMRVGREYVDLVMGSLFFVKQIHSMQASFNILHSSGTLISIQKTAIERDRSFYLEEKERAERKGQAYDAMSRIEANISKINQLEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LNM8</accession>
    <name>A0A167LNM8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_170889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288844.1">
        <property type="nucleotide sequence ID" value="XM_018436444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LNM8"/>
    <dbReference type="GeneID" id="28997350"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170889"/>
    <dbReference type="InParanoid" id="A0A167LNM8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="165" mass="18240" checksum="313EC717678566ED" modified="2016-07-06" version="1">MTPSSLSPHYAAQSPSGRKPDLVAKELLEWWQTNGKHPFIQPHISSPSNVGANSPENLPLGDKVQLIRLPVASPSAVKEFSQVSSEEPAHLTTGLTATETIYRLCENILQTKIKQRSKESITNVPKPLLFKRTQQSSSKDLAMKESNYTFSLLNINVDSIKMAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LUS2</accession>
    <name>A0A167LUS2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_182139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289179.1">
        <property type="nucleotide sequence ID" value="XM_018438572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LUS2"/>
    <dbReference type="GeneID" id="28999478"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_182139"/>
    <dbReference type="InParanoid" id="A0A167LUS2"/>
    <dbReference type="OrthoDB" id="2223665at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="105" mass="12231" checksum="10EED7A5020F471B" modified="2016-07-06" version="1">MSIIARISRKSMPVWRPVVAWSRAYTLIPSTPEQSKPSAQDIQDHNPIHALYNNHNQSVQDTHYADKKIHVANPEHYQSADTFSPAFNTVFDETRNLWAWDCIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LZ68</accession>
    <name>A0A167LZ68_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_147890</name>
        <name evidence="3" type="ORF">PHYBLDRAFT_170764</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289436.1">
        <property type="nucleotide sequence ID" value="XM_018431970.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289441.1">
        <property type="nucleotide sequence ID" value="XM_018436425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LZ68"/>
    <dbReference type="GeneID" id="28992876"/>
    <dbReference type="GeneID" id="28997331"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_147890"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170764"/>
    <dbReference type="OrthoDB" id="2296561at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008241466" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD71401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="14711" checksum="577884F80307C808" modified="2016-07-06" version="1">MKSSFAFVLLAMVLGLVCAAPMPTNDGENHNCFSLTYPVNGTVWNSYGTYEVLWDVTGTCHDTYYAYMISAVENEDGEYALSNPQKAPEPVDLTLGKNYITLNLNEPAGTYVFTISKESGEDIDYTDLAVITVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M4E1</accession>
    <name>A0A167M4E1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OAD71759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289799.1">
        <property type="nucleotide sequence ID" value="XM_018442723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M4E1"/>
    <dbReference type="GeneID" id="29003629"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_72814"/>
    <dbReference type="InParanoid" id="A0A167M4E1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="231" mass="26892" checksum="0E170528C3072760" modified="2016-07-06" version="1">MKNILLCKAGVQYCLGGWAAQIRLIDRRTSNFKIVSNNVAGPQLWSNPIRKTLAVIAIECNMNCHNLVSSLACLWDQNSTVIEHKTIELVCTTKIWKDNVVYRVRTSFDSRHIRANDLVVLEHLKEYGYVIKFFSHSVLGETRLFTIVDCLQGSNIQFSPKMTFRIKNQKYVFELNLKKQKQLKVCYIWYGDRSLNIVHLPSLEYFYSILTLEKYFEDESLIINLGNHFNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M5I7</accession>
    <name>A0A167M5I7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_169781</name>
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    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
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            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD71864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289904.1">
        <property type="nucleotide sequence ID" value="XM_018436161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M5I7"/>
    <dbReference type="GeneID" id="28997067"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169781"/>
    <dbReference type="InParanoid" id="A0A167M5I7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="140" mass="16225" checksum="094571A9DF0E8BE0" modified="2016-07-06" version="1">MGGFTNPNALELVTEILNHKRYAYIFYWYYIYFSQSCKKDRESMDDINQFFDKAFKGNGIVSALKVRNMTICFSVQKRRSLERICHPKHFNSTLVDRAVKSAIDQKAIKTLVPVLSVCPDIEFEFILGSTNLSQIVKAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M8D8</accession>
    <name>A0A167M8D8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_147085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290147.1">
        <property type="nucleotide sequence ID" value="XM_018431794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M8D8"/>
    <dbReference type="GeneID" id="28992700"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_147085"/>
    <dbReference type="InParanoid" id="A0A167M8D8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="68" mass="7246" checksum="F84B55339CAE3C55" modified="2016-07-06" version="1">MPHNVPFGGWLVILYDADISVDLIIKVGGNKLAAMATCQIGHMSNVKASSLKSVIIHKFKDPVPVDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N3C2</accession>
    <name>A0A167N3C2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_167214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292914.1">
        <property type="nucleotide sequence ID" value="XM_018435599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N3C2"/>
    <dbReference type="GeneID" id="28996505"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167214"/>
    <dbReference type="InParanoid" id="A0A167N3C2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="171" mass="20110" checksum="53AAB9BBA4BA3313" modified="2016-07-06" version="1">MLHEKLEEYNSAFEKIMEELEEPEMPEDPKSSAPSTTDETPKKSRGQYQKPTDKDIKKLLYLYFIRGLTIEKASKIILALLSYNCTVRIKNLSAMYPSANSKRGGANSDGNGSKFSWQWTQIQFLWKPIRCQWVLIRWKQMLIRWKWAPIEWIKPVVLIFIELELLSIVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N5M4</accession>
    <name>A0A167N5M4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_111658</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293099.1">
        <property type="nucleotide sequence ID" value="XM_018428225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N5M4"/>
    <dbReference type="STRING" id="763407.A0A167N5M4"/>
    <dbReference type="GeneID" id="28989131"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_111658"/>
    <dbReference type="InParanoid" id="A0A167N5M4"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045862">
        <property type="term" value="P:positive regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16654">
        <property type="entry name" value="RING-Ubox_CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045202">
        <property type="entry name" value="CHIP_RING-Ubox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="7">
        <location>
            <begin position="6"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD75059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="95" mass="11151" checksum="9FA0C111A7F32F01" modified="2016-07-06" version="1" fragment="single">KIQRREIPDAYLDKISFNIMHDPVFTPDGITYERQSLLDHFERNGHFDPITRRSCTENQLVPNLSLREAIEDFLKENGWAAGKKISKIKQIILRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N6J1</accession>
    <name>A0A167N6J1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_133116</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293179.1">
        <property type="nucleotide sequence ID" value="XM_018429549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N6J1"/>
    <dbReference type="FunCoup" id="A0A167N6J1">
        <property type="interactions" value="557"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167N6J1"/>
    <dbReference type="GeneID" id="28990455"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_133116"/>
    <dbReference type="InParanoid" id="A0A167N6J1"/>
    <dbReference type="OrthoDB" id="278325at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1230.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018279">
        <property type="entry name" value="Ribosomal_eS21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002148">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00996">
        <property type="entry name" value="RIBOSOMAL_S21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD75139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="86" mass="9608" checksum="690F07C3347B1A39" modified="2016-07-06" version="1">MENSEGRFVDLYVPRKCSATNRLITAKDHSSIQLNVANVDAEGRSTKSFATYALCGFVRKNAEADDSLNRLATQDGYLKSVWSYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N950</accession>
    <name>A0A167N950_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_143634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293424.1">
        <property type="nucleotide sequence ID" value="XM_018431033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N950"/>
    <dbReference type="GeneID" id="28991939"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143634"/>
    <dbReference type="InParanoid" id="A0A167N950"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="191" mass="22284" checksum="D2D6A107721CC5C7" modified="2016-07-06" version="1">MHPKAIFLLKTTYEIEVLYKHPLHNECSEFILNGRLSKVTTEDDIMITKLIETNTKTREIQRAINDEVYPDHKLYVSNIDSMNTAHAQRAWYLYEVMVVAATYLTNNLEIPLIWAEAIHDLRGETLKYFQLHLFGSLMSKLLLCHWYMLNSVKKVFSRKAESVTKKEQLMNHFNNAYADIKVDDSKIEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NVB5</accession>
    <name>A0A167NVB5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Presenilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_165206</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase A22A family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294726.1">
        <property type="nucleotide sequence ID" value="XM_018435179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NVB5"/>
    <dbReference type="STRING" id="763407.A0A167NVB5"/>
    <dbReference type="GeneID" id="28996085"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165206"/>
    <dbReference type="InParanoid" id="A0A167NVB5"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070765">
        <property type="term" value="C:gamma-secretase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.100">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001108">
        <property type="entry name" value="Peptidase_A22A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042524">
        <property type="entry name" value="Presenilin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202">
        <property type="entry name" value="PRESENILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202:SF13">
        <property type="entry name" value="PRESENILIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01080">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD76686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="49745" checksum="0D2C259471B40C12" modified="2016-07-06" version="1">MQAENSDSSDDQLPLLPNVPELDVHILDEPSNESPSVLSNDPATRLRDLVRFYMNQLTLLFYPLLVTFGLICWLETTLNMDPLQESGESNTDEDISMGDIMEQLGSSIIYALSMVLGIAMITMMFVLCFKYRFYKVMFLWLGFSVLSILGVTVSTIWIELMEIFNLPIDWITFVACMWNFSVVGIIAIFWSDGPLWLQQAYLIFISTATAISLLRLPPWTVWTVLVAIAVYDVFAVLCPGGPLKLLLDIAEERDEDVPALIYTAGMASLENTSETIGIYHTEETPCASSSKKPWTLFNKKKSGYERIIGEEGDVENSINTNSVNTHIIHNSSDGPFIQEGRESESEVLQEEDWNSVKLGLGDFIFYGVLIGRAAATDAITGLSLTILILTVKQQPLPALPISILFGSLTYAIGSYITTNMHIMISVDFIRSGNDLCVPSHLLKTSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P1T3</accession>
    <name>A0A167P1T3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_165578</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295124.1">
        <property type="nucleotide sequence ID" value="XM_018435263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P1T3"/>
    <dbReference type="STRING" id="763407.A0A167P1T3"/>
    <dbReference type="GeneID" id="28996169"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165578"/>
    <dbReference type="InParanoid" id="A0A167P1T3"/>
    <dbReference type="OrthoDB" id="5788137at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF35">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="150"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD77084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="268" mass="30860" checksum="AE9DB6385D373B21" modified="2016-07-06" version="1">MAYITSIGLYVPEWTSFNVGLFILGICLCLSAVATETLEPTPYSKFGNRLVDTIPTRWAMLAMYLPSLLVCALPFDHPHWPFSRFEWIHTITFLHFFKRLIEVIWVHRYSGKTNIVTTVIISSTYTATSFFDLLVVSRMPSSVFSFGWGLAGLILVIVGETTNGYHHYLLRQLRKDIVDTKSSTSSAYRLPRGGLFEYAVAPHYFAEQLTYLGLIFLSQNVVSLSIKFFPMIYLTLRAARTHEWYYDNLLKSEKILLASRKRLIPFVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P3K9</accession>
    <name>A0A167P3K9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_165666</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295218.1">
        <property type="nucleotide sequence ID" value="XM_018435276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P3K9"/>
    <dbReference type="GeneID" id="28996182"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165666"/>
    <dbReference type="InParanoid" id="A0A167P3K9"/>
    <dbReference type="OrthoDB" id="298344at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018866">
        <property type="entry name" value="Znf-4CXXC_R1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10497">
        <property type="entry name" value="zf-4CXXC_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zinc-finger" evidence="5">
        <location>
            <begin position="37"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD77178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="233" mass="27300" checksum="4B1953E3B51EB408" modified="2016-07-06" version="1">MFYQRSLRAEGSPVSYEFYTSFKDITFRNYIKKGRSEFADSCHQCRTKSDLKKVQCTAIRKYTGMRCSFKWDKSCLLKYNQKLNVALNNPKWRCPVCEGRCDCSRCRIKRGLRPYGNSWRIIRCTDTDDEDEDISGDKSVSIECNEDGNKAQAALFVTKPIVRERRKTAIYNRKYNFSRSIEVPKENSMDHSKKATYSLKKETRPLKILIKNSLKLDSILDQKMKDLTMKISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P412</accession>
    <name>A0A167P412_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trehalase</fullName>
            <ecNumber evidence="5">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_123152</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="5"/>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295246.1">
        <property type="nucleotide sequence ID" value="XM_018428910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P412"/>
    <dbReference type="FunCoup" id="A0A167P412">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167P412"/>
    <dbReference type="GeneID" id="28989816"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_123152"/>
    <dbReference type="InParanoid" id="A0A167P412"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011120">
        <property type="entry name" value="Trehalase_Ca-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF6">
        <property type="entry name" value="CYTOSOLIC NEUTRAL TREHALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07492">
        <property type="entry name" value="Trehalase_Ca-bi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neutral trehalase Ca2+ binding" evidence="7">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD77206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="758" mass="87299" checksum="BE517DA327B68288" modified="2016-07-06" version="1">MTQSTIHVTSEDVDVHAPASTYYTTGSNAGKSIRRLKTLTDSKRLNEQPARKRRASHDDKSKAQRFLIDVKETQRILVEQEDTDGDFQITVNDLGPKTFSVGTADSGGYRRIEIRGTYMLSNLLQELALADDYGRKHIVLDEARLNENPVDRLSRMIRHNFWDGLTRRIDAEGLEIISADPKNRSANHTPRIYVPHGEDQVFKYYTKVAATRTHLKLEVEMLPEKITPLYVKSINDRPGILALAMEKVTINGQETLQGVPFVVPGGRFNEMYGWDSYFEALGLLVDDRVDLAKGMVDNFVYEIKHYGKILNANRSYYLSRSQPPFLTDMALKVYERLPPTKESKVWLERAFQAAIKEYHTVWMAEPRLDPKTMLSRFHPEGLGIPPETEASHFDHILEPYAKKAGLSLEAYMSAYNDGSLKEPKLDEYFLHDRAVRESGHDTTYRYEKRCANLATIDLNSLLYKYETDIADTVEQIFNGKLTDEDRRPQVASEWRKRAAERKERIDRYLWNKEAGLYFDYDTVTKKQSTYETVTAYWAMWAKCASQEQADTMTLRLHKFEALGGLVSGTEESRGITSLDRPNRQWDFPFGWAPHQIMTWRAFQNYDKVEVARRLAYRWLYTITKSFVDFNGVVPEKYDVVSMTHKVQVEYGNVGTDFKYVPREGFGWMNASYQLGLDLVNTQMRRALGTCTHPDLFFEQALKRQQLFDTIQRRKSLEASARTITQNGQITAAITRIEAESSGPGNPVFDFTSHPFNHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PH38</accession>
    <name>A0A167PH38_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_68592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295944.1">
        <property type="nucleotide sequence ID" value="XM_018441975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PH38"/>
    <dbReference type="GeneID" id="29002881"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_68592"/>
    <dbReference type="InParanoid" id="A0A167PH38"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="110" mass="12824" checksum="8CBFDECCD6617E8A" modified="2016-07-06" version="1">MLNISYTKNIGFLFWHMNITWTEVKYIYILLSSPTKFRLWAQVKMFENSISFMQIVNGFSNWQENHLDIHDILITTLIPEILTTFNKGLDALDISIVIFNISSKAFACSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PHW6</accession>
    <name>A0A167PHW6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">enoyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="11">1.3.1.104</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_23418</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.104"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.104" evidence="11"/>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295994.1">
        <property type="nucleotide sequence ID" value="XM_018439805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PHW6"/>
    <dbReference type="FunCoup" id="A0A167PHW6">
        <property type="interactions" value="380"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167PHW6"/>
    <dbReference type="GeneID" id="29000711"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_23418"/>
    <dbReference type="InParanoid" id="A0A167PHW6"/>
    <dbReference type="OrthoDB" id="7482721at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000112">
        <property type="entry name" value="Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="37"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD77954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="394" mass="42762" checksum="AB1FED9367324BB2" modified="2016-07-06" version="1">MTILLRRLVLSSRPIGVRLYGSKVDKVEAVVYSSYGAPSQVLKWHSYGLPALTRDTVHVKFLASPINPADVNQIQGAYPIKPPFVALGNEDNFSTDGGDNDKVVKAAVGGNEGVAEVIAVGDAVSGLKKGDRVIMAKTGHGTWRTYAAGPPEDFQVVPNATSVSLIQQATISVNPCTAYRMLKDFIPPQQGKCDYVIQNGANSAVGQAVIQIAKAWGLKTINVVRNRYIIAIIAILRQELTALGATHVITDDQLGSFETKSLVKSWVGKNRLLLGLNCVGGKSATEMARYLSANGKLVTYGAMARAPLTLPASMLIFKNISFYGFWVSKWAETHSKEERSEMLADLVQLMAAKQLKEPRWTAVEWNEKAVKEAVENGIQGYGKGKQIVLFDKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PNM3</accession>
    <name>A0A167PNM3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_140362</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296304.1">
        <property type="nucleotide sequence ID" value="XM_018430390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PNM3"/>
    <dbReference type="STRING" id="763407.A0A167PNM3"/>
    <dbReference type="GeneID" id="28991296"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_140362"/>
    <dbReference type="InParanoid" id="A0A167PNM3"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="6">
        <location>
            <begin position="36"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="690"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="706"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="717"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD78264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="734" mass="80276" checksum="895167FBA06F0AA8" modified="2016-07-06" version="1">MSSSTRPSFSRTPSIASSIQYNPKRATAQTILTNCTLHDILTNPRLLFSFERFLRGTWSHENLLFIEAMSQLRHESDPKIVETTLHRIYKTFIACGSPLELNVTTQAKVKSKIDSMQWAILSRKEAVSILAETEDQVLTTLNAKLAEYLEASKGSPVDTAVSLSLPQKLQKKVVIIGGGFTGFTVGSILDPMHLFHVTLIDTKDSFEYTPGIVKKIVNPSQSSSLRVRHDSYILNGKVILGHVEEICSDAMSLKVNGDLISFDYLVVATGSSYSSQLKSTDISSLYRLSGLEDLNTELQNARKVLIIGGGLVGCELASEIADFEFPGPYPKKSITMVESHSNVVSRSDVRQQERAHDYLVNLGVEIVCNERIVDFDSAEANVYVGSTGRVYQGYEKVFVATGTRPNSDLFMSSTSELSLESCLDIWGRIRVKPTLQIDHFSYQHIFAGGDVTNVVEEKTGYAATIAGVCIARNICRLVKGKPALKQGTKGTLPAPDKPLHGMKAHGGIGKQSLNILKKKFSFLNPSWAALKYFNETQFTRIVQGQGSMSSHILGRLPRRLMLPSSSNSPTFPTASFSTLSIATSPSLFTQSECSLDTPKDLSDRTTSKMLCTADSATAITATITTTTSTMAGCSSNRNSCDSCGRKSTSRCSSCDNDSSSSIDEYLVEHFTFGGENIELFAEERRRSIKAAKEEPPLSPRIKSRRTSVVSSYSTCSNKNSISPRNSASTPPIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PXH6</accession>
    <name>A0A167PXH6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_107369</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296749.1">
        <property type="nucleotide sequence ID" value="XM_018427993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PXH6"/>
    <dbReference type="FunCoup" id="A0A167PXH6">
        <property type="interactions" value="451"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167PXH6"/>
    <dbReference type="GeneID" id="28988899"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_107369"/>
    <dbReference type="InParanoid" id="A0A167PXH6"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF32">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="10">
        <location>
            <begin position="122"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="9">
        <location>
            <begin position="312"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD78709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="627" mass="69677" checksum="32E8610B4320EE50" modified="2016-07-06" version="1">MSLLFARKAFSSVKLGHPLFRSSRLVGGCLPRYIHSLPPGFISDPKYDKAVQLTELRGVNITHDPLLSKGTAFSMDERERLSIRGLVPPRQQNMEMQLKRVKRNMAHCETPLSKFIFLNALQDRNETLFYKLVIDNIKEMAGIIYTPTVGLASQKSHSIYRRSRGMYFSAQDRGNMSAMVYNWPHPDVDVIVVTDGSRILGLGDLGANGMQIPVGKLSLYVAAGGIHPRTVLPVVLDVGTNNQELLHDPLYLGLPQPRLKGEEYYAMVDEWVRAVTGRWPNVLIQFEDFKHPHAYNLLNKYRNKITCFNDDIQSTSTITLAGILASLKARGREQEDLAKERIICVGAGSAGVGVCEGIIDCMVTQGKVKSREEAYESIFMLDQDGLLGNHSLAMKDPSNFHQSSQREEPLDELQLRYVKKDLPDRLGLEALVETVKPTVILGLTGIRGVFTEKAIRTMSRYQEKPVIFPLSNPDTHAECTAEEAFEWSDGRAIFASGSPFENVELKGGKIGHTNQCNNSYSFPVSSIGIGLGVTVSKASRVTSTMFLEAAKVIAELATEDELKQGILFPSVSKLRDVSHKVATRVCEVAYTEGVAKATLKEGELLSDLVKDSMYTPEYVPLVHFEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QJP3</accession>
    <name>A0A167QJP3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_139822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297841.1">
        <property type="nucleotide sequence ID" value="XM_018430286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QJP3"/>
    <dbReference type="GeneID" id="28991192"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139822"/>
    <dbReference type="InParanoid" id="A0A167QJP3"/>
    <dbReference type="OrthoDB" id="2276959at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD79801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="98" mass="11473" checksum="F0EE559128A5760B" modified="2016-07-06" version="1">MSSFVFVANPGKKISLEHATHPCPRCKHQSSVQLTRSEKQIIVLNKRISDNTSVRYECSQCRWKNEELPYDTEAEVRRYLNDAEYQDVFSRPMTGQTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QMQ6</accession>
    <name>A0A167QMQ6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_139951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297979.1">
        <property type="nucleotide sequence ID" value="XM_018430309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QMQ6"/>
    <dbReference type="STRING" id="763407.A0A167QMQ6"/>
    <dbReference type="GeneID" id="28991215"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139951"/>
    <dbReference type="InParanoid" id="A0A167QMQ6"/>
    <dbReference type="OrthoDB" id="2162799at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="701" mass="78965" checksum="A7A9853C4E7CDB2F" modified="2016-07-06" version="1">MDMDMDMDVDVKEGYRREGDYSSSPLGFLKELAPEKLELTQDQSYPGSTANSIQEENVIHSYCFRRGPMVQLHPSNTWPIGYLSPVGMLSGSLMYTIEDNLLDPHEIRHSSKRTNPSHTDDTFERLDRRKEPGKKYWSKRKRSIAEDVRDRKMQKISSNLANDIARSLSFTDPDSNPRSTQDVDDIEMLITPDTKDPSHLLQTSPALSTSNLSSIHGFPSNGCPVSQTQRVYRKCARPFGTRRSGDTAMHSLASGRDSSPIPTLRRISLSGALSPAIDLDQWLMMQAHRQQISVQDYKLLFQEKKKQLQQCLQKLHTSHPTNSDTQRYEEIKENLGKILSIADELSGDHSLSFAEIFPEWRECEGHLNKLASYVQSIEDMKHLNSQTIPRTNDLLHDIKYLQSVLEDKHNLYGECLVQNGLEWKTMGMPVDEHLLAATKGWFYSLSIGLLRELDTECSKAQSLVTNMRELVNSALGEKLMAAILHGIEFISGSTALIGLPSRKLTFGCRVLATVYGHWISENLGYLNERQLAEFMAGTTNTPSTPTNINVPKAIRTDLRLMQCLESMARVLAALQTLQEVDSGQKSVAKGVFHPSLLRDVDDDDPFDGETVLENLTSLLVEITVRTVAVIETSRVQITKLNTAKSANIMVNPQMALVYMQEALLSFADQILELSGRDWQTGARLQRLHAHLEDMENEFAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QSC4</accession>
    <name>A0A167QSC4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_185093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298227.1">
        <property type="nucleotide sequence ID" value="XM_018439029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QSC4"/>
    <dbReference type="FunCoup" id="A0A167QSC4">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QSC4"/>
    <dbReference type="GeneID" id="28999935"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_185093"/>
    <dbReference type="InParanoid" id="A0A167QSC4"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15858">
        <property type="entry name" value="SNARE_VAM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="3"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="1">
        <location>
            <begin position="276"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD80187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="39146" checksum="36D324A95543FFB2" modified="2016-07-06" version="1">MSQMIQAIFVPKVDNISKPKAHTVYCLDVHAAVRTWQVWRRYSEFVRLHEYFLEAFPHHSLPSPFPVKRYFPSTFSSPTKVDERRRALETYLRGILASQDARWRQTQAWRDFMGVPVGRQVNECPSERWLEEFEQLNNYTHQIRALVNRRATHLARNETSASHNCTVHAKRLLNTITTRMASLSHLLGGLSEGEQRRRQDLLNSLREEKDSLHHLVHAGRYTDTPTPQADETPEMVSVQAIPTKGRVFGPSSKKVILQDTPKTRVLDNEGLIGYQKQTMKDQDNNIEQFLSVLARQKQIAFAIGDELSLQNQLLDEIDQDADTTNLKFKMVTKKVMAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QTC5</accession>
    <name>A0A167QTC5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_59276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298288.1">
        <property type="nucleotide sequence ID" value="XM_018440465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QTC5"/>
    <dbReference type="GeneID" id="29001371"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_59276"/>
    <dbReference type="InParanoid" id="A0A167QTC5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="119" mass="13294" checksum="85D1A10C53261707" modified="2016-07-06" version="1">MCAWCVTVPEIVNLPGSLAKRNQCLVVGSVLHSIVVLMLRGDVSKMNYVHCRRGILLAWGTMILNEYNVDKYVNKGKGKSIVCRRNREQKQDFSCAQKNSSLTTEGTVPHQQTIDISLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QY09</accession>
    <name>A0A167QY09_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zn(2)-C6 fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_76709</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298489.1">
        <property type="nucleotide sequence ID" value="XM_018443181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QY09"/>
    <dbReference type="STRING" id="763407.A0A167QY09"/>
    <dbReference type="GeneID" id="29004087"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_76709"/>
    <dbReference type="InParanoid" id="A0A167QY09"/>
    <dbReference type="OrthoDB" id="1555531at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF7">
        <property type="entry name" value="FUNGAL TRANSCRIPTIONAL REGULATORY PROTEIN, N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="78"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="422"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="505"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="422"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="517"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="535"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD80449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="638" mass="70344" checksum="8389C5D8224692D1" modified="2016-07-06" version="1">MNVLLQPYTLPSPASPSGTLCSRPSPSEETAARKKRPSKAQVPVACVNCKKAHLACDLTRPCKRCVCVGKSDSCHDIQPKKRGRPKLGERRDGPTKQRPLSTRSNFAKSTVSSISVPNMMNSSFAMTQNLGYPEHRNSQNNKMMTIFLTMDMCCARASDESLELLGIYPQEFSHRPLYDFVLPEHSGKIGSAHRRLLDNATQLYQKYKVDPKTSLPPTRRTTSSSFTDTPPSTLLGIANGSQTLKETLVFRCVHQPDETFEACFYLGGGLGADLFDPNSAENLYVVCLMTRKPPTVNLETASHTPSHTHTHTRSLDGTRSPFIQLDSLPEANPVPTQSTIHNRNHSTSSVPTTSEASLLLDHEIDMAYFRNPLSSVNGSTSPLSAEFMSVFAPSDHSSERIDCRGNQVGSLSHPVQRTLSVSPVNSCNLGPTMTGNRNNSVDSMAPSQPTTSQSVVNSWPKSPAYSRASSAIDYDFSPDISQGALSVAGSQSLEFEPLNTQLTSSKSLNHLTNPGQHRQHQHHSHSHNNQHHHQTQTQNQQQQQQQQQQQQQHPHHYPQMPFMHSNPNEYYYTQMTSSRLSAEARAIVSHSFPLSNPGLTGTYKPHPQNSINPVAAHHAAFVQSKSNSISLSNPTPNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R6Q7</accession>
    <name>A0A167R6Q7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="3">1.3.1.124</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_176572</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="3"/>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299017.1">
        <property type="nucleotide sequence ID" value="XM_018437799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R6Q7"/>
    <dbReference type="STRING" id="763407.A0A167R6Q7"/>
    <dbReference type="GeneID" id="28998705"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176572"/>
    <dbReference type="InParanoid" id="A0A167R6Q7"/>
    <dbReference type="OrthoDB" id="2136131at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD80977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="276" mass="29409" checksum="AFF480CB3DC787AB" modified="2016-07-06" version="1">MSASVPTTQIFKDNIFAGKVLLCSGGGSGICRGMTEAVLRHGAKAVIISRSLDKLEKAAKEMRESTGGEVIAIAADVRKPEQLEEAVRKTVERFGHIDYLINGAAGNFLAPFENLSYNAFRTVIEIDLLGTFNLTKAALKHIKASKGAIINVSATLYYTGTPFQQHAGSAKAAIDALTKHWAVELGPHGVRVNGIAPGPIESTVGMEKLGPQFDATAVPLQRMGSVEDIAQSTVFLFSDAANWISGVTLVVDGGHWLNATYPGYPDFILTPLQGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R907</accession>
    <name>A0A167R907_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_72961</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299178.1">
        <property type="nucleotide sequence ID" value="XM_018442750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R907"/>
    <dbReference type="STRING" id="763407.A0A167R907"/>
    <dbReference type="GeneID" id="29003656"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_72961"/>
    <dbReference type="InParanoid" id="A0A167R907"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="247"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="299"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="247"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD81138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="356" mass="38727" checksum="929FEF6D658D1660" modified="2016-07-06" version="1">MSTPLWMNQQKKTVPVTSFFDFQRAATGRETPAVRLRQAAIDGNIPAVKRLIKKVPNIQNPDPSNNYTTLMYAARHGHVELVELLLNMNHEEEVISVDNKGETVLMIAAMYNHEEIFYNYASRYQECVHAISKNGWTALLYAAKNGNANLVNYMKTISADIDHVDYEGNSALHYASAWGHTAVMELLASLGCNLDLENNSRFSASDYAYSFSVKEHMKTLPQVQQEAIDASLSSSFKQSNYHRPCLSSLSSGTHPSLGTTLISRGPSYSGYESPTPTPRASTSSSSIVANSVSMTVSSSPRGSYFQQAINSSNGSGSGSGNNGSGNSGSGSSNTDGERQRAASFGDQARSLRYRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N2H1</accession>
    <name>A0A162N2H1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_184209</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441030">
        <property type="protein sequence ID" value="OAD65174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283214.1">
        <property type="nucleotide sequence ID" value="XM_018438902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N2H1"/>
    <dbReference type="STRING" id="763407.A0A162N2H1"/>
    <dbReference type="GeneID" id="28999808"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_184209"/>
    <dbReference type="InParanoid" id="A0A162N2H1"/>
    <dbReference type="OrthoDB" id="340346at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="473"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="646"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="57"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="230"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="374"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="996"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="267"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="996"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1007"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1029"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1079"/>
            <end position="1089"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD65174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1089" mass="121476" checksum="588106E673E78C4B" modified="2016-07-06" version="1">MNLNKLSKVGRCFWNEFHAADVTRDDEAGVVPVSELYALLSRTCNRTLDLGFDFPDEQDDYDIDDETFPPPSQSVDKNPTNQLSSDAPASISRTDNSTVTQHKEPIDEKERDNKMTKPTQDKHSESLLQAMAQDGPDASLEDRMANEPMSPMERICMLEKSHEEIHRLLLAKELAETLDEITVEQAVCDVLPMIHRVGTDPDETVREQLASELDKMIMYYYKNAPPLAPAPAPVSKMKQSPESESPLSPSQDVEMTTVSLNFNPLDNPTSNQPNPTPAPTTTHTPTTTTTTTTTTITKKKPTQPEFHIQSQVFAPLLINFLLDQNTALTNLGQQCIMSVANFLVSKDTDFYRSLLQSDIIDGVLMGLVAISEGKSHHGQDDDENDGGEDDHNNNNSSGGNNSDSMDIEHNQARRASANRRGSVPGFEGSGYMSSFQSSEEPEEGDMNMAKMTCLTLISAIAHILGPDLCIKHCVPIVEKLAKDNMFFVRKEAGVTIGSLASVMSQQDVIERLLPIYHSFSKDNIWHVRQACVISLPPLCGALPEDQKVQLAVEGIVLFETDTSRNVRSTLAETVGELIAKFLPNDWETTRRPGKVPEVLLEFFLSLANTATSGQMFKLETDRAIICAYNFPVAVLTAGHEYWDSHLRETYLNLTKNYQIKVRCTFAYSLHEIARIIGPENTERDLVQIFAMYLMDLDDVKQGVLEHLADFLGTLAVTSRNEYIPILAEVWDGVMTNWRLRAILTAQLRDIALLFDASRVVEHILPLAIRACHDEYAAVRETGVRVFPVILEVVKQAVVEENESDTQSFDEDEDLAGNKIALLSHVMERLDEFAKAEMYRSRLVFANICKMLLEVGISAADFGAFFIPRLGPLAYDPIVNVRIAAARTIRVAYKDDRFCKALYAIHPLEGIDHDEVPPGQAIDHMLYRFALDSDKDVRSFAEDLVDPIQLEERRCEMKAAEEVAIDVPVRTYVSGDYYGSSSVDGIGNGDTKAEELRASTHMQEIDRTSSSSSSVTTDSSGVNSMEDEESSAHRQHQEENTHMEEDEPMGDLNRPTKSIESDETDKEYVYLSKSPPLRDSSPTTSVVIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N4F3</accession>
    <name>A0A162N4F3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_68997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286478.1">
        <property type="nucleotide sequence ID" value="XM_018442039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N4F3"/>
    <dbReference type="GeneID" id="29002945"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_68997"/>
    <dbReference type="InParanoid" id="A0A162N4F3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="202" mass="22802" checksum="9539F60C9095B248" modified="2016-07-06" version="1">MIEAYSPPRVYSARSVERAIGEYLRAIKSNSEIGINAGNIMLGLTQIRQMRVKNSITTTATVTATTLLQYDDPSAGWPIDQEDSNVGTNSDIEFWGPLRNRMIVDSFGGISCLPELLQKFYESKEEECSMIEAAIKTSHKAFVNGYVIDSALDHNCVREAHNVRLQVQVDENRNIGQSYSPIYKDFFGKVVVFFEHKLNNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N718</accession>
    <name>A0A162N718_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_170410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289788.1">
        <property type="nucleotide sequence ID" value="XM_018436336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N718"/>
    <dbReference type="GeneID" id="28997242"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170410"/>
    <dbReference type="InParanoid" id="A0A162N718"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="233" mass="27274" checksum="6095F0E1ECC581AA" modified="2016-07-06" version="1">MLHEKLEEYNSAFEKIMEELEEPEKPEDPKSSAPSTTDETPKKSRGQYQKPTDKDIKKLFYLYFIRGLTIKKASKILTVLPRSSDFMETFEGNADDCNLNYHPIQTRPVKKSCYAFIKKPIYMEGVSTQDKVSDFEDLIMLEDKPKGKQCYKAYTEEETLLVLKKYFVDEMTMSEVEKSIDISRSTAGWVIRHIRSRLNLPARKSHMHKYASLEEYEKTLCKNVQTMLLQKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NBU2</accession>
    <name>A0A162NBU2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Corrinoid adenosyltransferase MMAB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:co(I)rrinoid adenosyltransferase MMAB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_146238</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Converts cob(I)alamin to adenosylcobalamin (adenosylcob(III)alamin), a coenzyme for methylmalonyl-CoA mutase, therefore participates in the final step of the vitamin B12 conversion. Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to MUT in a transfer that is stimulated by ATP-binding to MMAB and gated by MMAA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cob(I)alamin-[corrinoid adenosyltransferase] + ATP = apo-[corrinoid adenosyltransferase] + adenosylcob(III)alamin + triphosphate</text>
            <dbReference type="Rhea" id="RHEA:56796"/>
            <dbReference type="Rhea" id="RHEA-COMP:14743"/>
            <dbReference type="Rhea" id="RHEA-COMP:14744"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60488"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:56797"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290958.1">
        <property type="nucleotide sequence ID" value="XM_018431608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NBU2"/>
    <dbReference type="STRING" id="763407.A0A162NBU2"/>
    <dbReference type="GeneID" id="28992514"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146238"/>
    <dbReference type="InParanoid" id="A0A162NBU2"/>
    <dbReference type="OrthoDB" id="549173at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:corrinoid adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009235">
        <property type="term" value="P:cobalamin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1200.10:FF:000001">
        <property type="entry name" value="Cob(I)yrinic acid a,c-diamide adenosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="entry name" value="Cobalamin adenosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="CORRINOID ADENOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213:SF0">
        <property type="entry name" value="CORRINOID ADENOSYLTRANSFERASE MMAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="Cobalamin adenosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cobalamin adenosyltransferase-like" evidence="11">
        <location>
            <begin position="3"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD72918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="190" mass="21433" checksum="8D7F96E20851A879" modified="2016-07-06" version="1">MKIYTKTGDKGTSSLYNGERLVKDDDVFEALGTSDELSSNIGLAMSYLEDQKSKVLVEQLLQIQCLLQDIGSNIATPRDRSNERKLQRTTFDEEGEHVAQLEKWIDEMDAELPRLTKFILPSGGKASASLHVSRSVCRRAERTVQILVRDQLCDNSVGIYLNRLSDYLFNAARTAAYQIGEPERIYTKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NES5</accession>
    <name>A0A162NES5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_145164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291728.1">
        <property type="nucleotide sequence ID" value="XM_018431378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NES5"/>
    <dbReference type="GeneID" id="28992284"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145164"/>
    <dbReference type="InParanoid" id="A0A162NES5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="118" mass="13201" checksum="3225962692FD2BE1" modified="2016-07-06" version="1">MLVKKQKFALAWFLKPGAASSSKKVVETRIWLPGNPQTDNSRMTMAVVTPFDSLHIKMRFVRFTKRTSCRSVGPGAKPMRSEPKVDPEASDSKDWIIVSLWDRHHAPPVSLVLSLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NFR9</accession>
    <name>A0A162NFR9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_168249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291858.1">
        <property type="nucleotide sequence ID" value="XM_018435827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NFR9"/>
    <dbReference type="GeneID" id="28996733"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168249"/>
    <dbReference type="InParanoid" id="A0A162NFR9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="102" mass="12133" checksum="6B33E41AAE239D50" modified="2016-07-06" version="1">MLMSSYVAIEVEWYGISIITWAKDKSIDKICEMFLHCETVDLVTERYTTPIFEAKYRISLREVIPFSCVAYPDRDMHPNVEMKPQKIGKTFLSILVHWKRDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NFX9</accession>
    <name>A0A162NFX9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_172431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287214.1">
        <property type="nucleotide sequence ID" value="XM_018436802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NFX9"/>
    <dbReference type="GeneID" id="28997708"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172431"/>
    <dbReference type="InParanoid" id="A0A162NFX9"/>
    <dbReference type="OrthoDB" id="2206543at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="677" mass="76603" checksum="7D850DA75D3474A9" modified="2016-07-06" version="1">MGSFLGDHAITSRGTSFLQWIQATGLTCWNELLAFGIPTFLSGGSGTSRSSIIDLFLSTSPLLNPSMQIRSDLSLGSDHKMVNLTFTPYVSPPPPPTNHPRLLWNLSKLAQPDTLKIYIDTASGSLDNLTEQFSAFLSSSSPPPVDSLCSAFAQAIYDALDTAVGRRTPRTMQKYWFWSVDLQEAMDLRERSYQRWRHSSGLQKAICWMRHQDACHAVRLSVQRRRRETWKEFCNKLATQDFAKTTATMKRIKSHRQTSPVFVDPGGPQVAANKMADHLQQIFSGQFLPARRPPDQTVMISSPIAIDESCPFTHLSVESAILKLPTRKAPGVDHLRAEMLHPIVKQVSPVLCLLFQLCWQWAKGTIDPSLLISRNCVSAINSMRALQSLGVNHTGLSRLLSIRLYRQFIRPQFEYGLAISCFNIKQVAVLEKAQNTCLRMIFGGHSTSSTSVFRHLGNLPSMRERILTLGFKFVYRAFWLPDEALFTLLRPVLTNPAHQWFKLLANPIWLSLSNRQNADSKACKHAIRSFLNQGLFLQRSQQILLSACRPSLGVDPILWLPMTNYERSRFIRWRMGWLPGRPQPCSCGLHTTSRHHVIECTGAAIRLHLYSTVQPNPIDYVLNMLPLKKLKNNKNNAFWIFTWPILCRIMLDIEQICLPGVDLADHAATDRGQLFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NJK7</accession>
    <name>A0A162NJK7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_144167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292848.1">
        <property type="nucleotide sequence ID" value="XM_018431153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NJK7"/>
    <dbReference type="STRING" id="763407.A0A162NJK7"/>
    <dbReference type="GeneID" id="28992059"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144167"/>
    <dbReference type="InParanoid" id="A0A162NJK7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="36156" checksum="401B5F9E7CD54E6F" modified="2016-07-06" version="1">MSSFKFVYEDSQEKSVNEDSSQALIHIIDEDYHGLETIATHSQFLESRNRDRISEVSESNQTENQNIIKFFKLKDEKLLSAKTAAKQLNISARVAQFWVKKYNEDPDNLFNHDKKEDTSVYVKDVMDYCILVFGNINVLKETVRRFMANKCNLTLKKIYKQSVAKNSEENIEAKYNWILQMKKTSANYMTNCVFLDKSAFDINMWHRREWFEKGKKEVTTTPTTRFHPLTIFGAMLAKGLIYISLRNPKFCKQFSSAESGSKGTVARHFFMFVKAVFDKIDKYVNMKGNFLVIDNAPIHQSADISLYISSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NJZ8</accession>
    <name>A0A162NJZ8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_158543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292968.1">
        <property type="nucleotide sequence ID" value="XM_018433811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NJZ8"/>
    <dbReference type="STRING" id="763407.A0A162NJZ8"/>
    <dbReference type="GeneID" id="28994717"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_158543"/>
    <dbReference type="InParanoid" id="A0A162NJZ8"/>
    <dbReference type="OrthoDB" id="2288664at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="248" mass="29484" checksum="D0A018FA0019A265" modified="2016-07-06" version="1">MGDEVERVKELLVYESRMTAMKHEAQIQNLNSEHTETLRELREQFDNEKEVWKIEHQAALDDLKRQLKREHQNVTRELEHSWKDKMADLQSLMSIDSLSNQKHWENKMSEIQDEKESRVNRLQGQIEVIKGRLGNEIDKRRQCQALLEVMKQKEYQDQEQGEIYRAQVSRLVKVQKLTEHEIDKLKREHRMANKLARNMLSMVGLEEEKSNGQNIRLADMLERIVHHIVLQSSGRLASEQIMMMNGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PJ61</accession>
    <name>A0A162PJ61_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Autophagy-related protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_78240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize preautophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Preautophagosomal structure membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATG17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291407.1">
        <property type="nucleotide sequence ID" value="XM_018443346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PJ61"/>
    <dbReference type="FunCoup" id="A0A162PJ61">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162PJ61"/>
    <dbReference type="GeneID" id="29004251"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_78240"/>
    <dbReference type="InParanoid" id="A0A162PJ61"/>
    <dbReference type="OrthoDB" id="1937984at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007240">
        <property type="entry name" value="Atg17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="8">
        <location>
            <begin position="15"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="318"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD73367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="451" mass="51647" checksum="9CFD9F7F22EA5D7F" modified="2016-07-06" version="1">MEQELIELLLAAKKALSTGQNVCAQANTRSQESGKHVEVIEKTWPKILFLHNHIVSQFSTLERIRDFILIKTDEARNCIKDHETTLANVSMELTTIFEMLKDYSVDEAILKENHKRANQFQSGMEASGVSPISQNTTLFNYIDDQAVLELQRQTDDEIGEIENVCSSLIAMTNTLSAAMGELEILQESALSISLDEGASNFANEKTQIQEDEISKMADILTSLTNHYDQLGEATRLCQSEPEACKQLDISVLQDDHDHVPDILEDLRESLEIVESVSEETRVRMKVYLSVQKELIRVLTELELFGSPRGVVDTVYEKMLSAETEMNESKHNLDALLKQLMDLAERYRLYLESYNHLVLEVERRRRVVEQQERQQKELIRAAEESYNNELEERRAWFNQHGQYLPDALCPFIFDMPTILTVNLEPNTMRLPEVSKSSIQKAISDIHRNKPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PMH0</accession>
    <name>A0A162PMH0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_171710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288366.1">
        <property type="nucleotide sequence ID" value="XM_018436650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PMH0"/>
    <dbReference type="GeneID" id="28997556"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171710"/>
    <dbReference type="InParanoid" id="A0A162PMH0"/>
    <dbReference type="OrthoDB" id="2278238at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="177" mass="20023" checksum="B856792830A36DF9" modified="2016-07-06" version="1">MSCKSCGGCFTGSGCITTKKSSDKIQQTNERFSALLQLASTSNTTTSDHDHIIPTITAELARNNYSSQVSLLEAHSQLSLEDFLELAQLYWFYDIRGFLIAWTWEYHKGNAIQCLEAMRDQGNQKLLLWDYLDGQAEIHETFNGLELGMAGRVKRDPTNKWFGKIEMPTSLGLAFWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PW01</accession>
    <name>A0A162PW01_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_181163</name>
        <name evidence="2" type="ORF">PHYBLDRAFT_181270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292270.1">
        <property type="nucleotide sequence ID" value="XM_018438426.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292656.1">
        <property type="nucleotide sequence ID" value="XM_018438442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PW01"/>
    <dbReference type="GeneID" id="28999332"/>
    <dbReference type="GeneID" id="28999348"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_181163"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_181270"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="81" mass="8878" checksum="9CC8B5BD9A9D95E1" modified="2016-07-06" version="1">MSSSNDESIKFFHSYLVRVPARPSLFSSCACGVSDGWVLPIASLTPQRSRSPPHSVLFHEVRTGLRPVEDGSAFIGGELRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PZ67</accession>
    <name>A0A162PZ67_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_179823</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295387.1">
        <property type="nucleotide sequence ID" value="XM_018438215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PZ67"/>
    <dbReference type="FunCoup" id="A0A162PZ67">
        <property type="interactions" value="691"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162PZ67"/>
    <dbReference type="GeneID" id="28999121"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179823"/>
    <dbReference type="InParanoid" id="A0A162PZ67"/>
    <dbReference type="OrthoDB" id="431626at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056840">
        <property type="entry name" value="HEAT_IPO9_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF9">
        <property type="entry name" value="IMPORTIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25018">
        <property type="entry name" value="HEAT_IPO9_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="915"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="922"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD77347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1025" mass="114974" checksum="97A83FA5CCE49D46" modified="2016-07-06" version="1">MDQAVYETLLKVADPDGGIRSAAEARLKELGNAPEYPVSLARLTVSRDFPNDNYLAALSLKTYVTTRWTPKDDLSPNGFEPPQESKKAVREIIVTGLADSESKIRVVCAYVVSKIAHDDFPEDWPHLLDILMSYLKSNSADSVHGAMRVLLEMVKKDISIQQLPQIGPVLIPELYSILTRDTVYSFRTRGRAVDIFSSCVQMLSTLREENPALADQFIAPIIPQWMQAFSVILNHHVQGNPEKATEEYGLKMEVVKCICTISGEFPKYISTSLPLLFEPIWMDLFNLRERYVAEFVSETGDDGAESFQDSDGNEIGFQSLLYVLFDFVAAACTKKTVRHLFLTPEGTHTSFFEQLLYVYIIYMQITQEQAETWLSDANQFVADEEDGTFTFNARVAAIDVLLTLQEAYPAPFFNALGVALQRHIGESNEARAAGNEEWWKVQEACLLAIGRLSEELMESLEDESQKIQFDLKSLFDHVVLEDMKAAEYPFLQGRAFVFASEFAKILPAEMAAQYVPVAVHALQAPASGIPVKISALRALHNYCKYLDAQYVTPYQVNIMEGACQLLPSATEESLMLLMDTLGSAVRINGEVAAKYEHILTPAVLDIWKRFPSDSIITSYILDVFEEFAKNPHYAPALYARTLPFLNQVFTATGTDPTVYSSAVDLLTAMITYGPSPLPNEFSEQMFPCLMQLAWNVPDNDLLQSAQECLRRFMIKDCEHIIQWRDPAGKSGLDYVIHFVAKLLDPANSESEALFVGDLIVTLIQKAGSNIASVLPDLLNAVLVRLETTSYQPFIQSLVLVFAHLIINQQDTVLQFLTSTNINNKSGLEILMNTWCDNHDSFSGYYSLKVSDIALSKLLLVNDPRLQSMTVKGEIVVNPDGGIVTRSRAKRNPDQYTAIPLYTKIIKLLVADLGNTMPNDQAPQEDAESVGDEGEDWEDLDDDPTFSSRQEFSFLSDILANIPDDEDDEENDPGLKDDPIYKTDMKEYLTDFFRNCSTHNVNHFVEICQHQLNDEEKHILSLALNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T9K7</accession>
    <name>A0A162T9K7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_151987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD67042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285082.1">
        <property type="nucleotide sequence ID" value="XM_018432800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T9K7"/>
    <dbReference type="GeneID" id="28993706"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151987"/>
    <dbReference type="InParanoid" id="A0A162T9K7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="209" mass="24097" checksum="871C1355CB95CCE5" modified="2016-07-06" version="1">MSIVQETEYQDIQTNNSPKNLLTPSESVEEKSDVDNEYYNNILNYDKCEESDDGSRVDNSDFDVEENTETNADISLFNHILNNISAFANNNESSINEENEFQSEVFNSTAWNRFIPNIHSFKDIQMMILLALVNDNNDMISYRILDVTFSDSTKVTAFLNLPSEHIKLLAADPIKSKSIFFYLIARQNNLFVFNKEKNREQIHTYCCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TGF8</accession>
    <name>A0A162TGF8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_68935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286422.1">
        <property type="nucleotide sequence ID" value="XM_018442029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TGF8"/>
    <dbReference type="STRING" id="763407.A0A162TGF8"/>
    <dbReference type="GeneID" id="29002935"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_68935"/>
    <dbReference type="InParanoid" id="A0A162TGF8"/>
    <dbReference type="OrthoDB" id="10440056at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="15977" checksum="D0CCD8C6EF45EE86" modified="2016-07-06" version="1">MVLVGEVDTSLLDHRDRRQIWERRFYRLIGSQFIGYAYEEEEPWVPRERYDIADAVRLSAAVDQVIVTLEDIPEDGRLFQTETIWEDNRRGFFRLAFPDFHLDCVSDQVEESEEWVRALRSMIGRIPLRIPFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TI85</accession>
    <name>A0A162TI85_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_150392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286842.1">
        <property type="nucleotide sequence ID" value="XM_018432470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TI85"/>
    <dbReference type="GeneID" id="28993376"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150392"/>
    <dbReference type="InParanoid" id="A0A162TI85"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="147" mass="16472" checksum="5273C3C2BD6FF5FA" modified="2016-07-06" version="1">MSSTQRCCAACHMLGHSRSTHKQCLMNPKNISLHIPQKKTNVNEYPAETAALRIRSESVQDQNLDIETLTSISVSELTEFPLANETITEVLEAVMEEEIEETSSNEEDQFYSIVLTVTELIIAKLQADFVQTITVAEQEDLEIEAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TXT0</accession>
    <name>A0A162TXT0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_126467</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="FunCoup" id="A0A162TXT0">
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    <dbReference type="STRING" id="763407.A0A162TXT0"/>
    <dbReference type="GeneID" id="28990011"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_126467"/>
    <dbReference type="InParanoid" id="A0A162TXT0"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000162">
        <property type="entry name" value="Glutathione S-transferase Gst3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
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        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01148">
        <property type="entry name" value="Xi_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="154"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="120"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="138"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
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        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR015753-3"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD70683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="316" mass="36592" checksum="D7B761876C741112" modified="2016-07-06" version="1">MSTKPAILNWASKDGEFKRQQSVFRNHIEADKNATFAAEKDRYHLYVSWACPWAHRTAIVRKLKGLEDIISISAVHYLLGEKGWKFASAEECPGAIPDTVNNAQFIREIYFKANPDYEGRFTVPVLWDKKHNTIVNNESSEIIRMFNTAFNHFLPAEKAKLNYYPEELQSDIDSTNEWVYDTVNNGVYKSGFATTQTAYENHVFPLFKSLDRLEKILSENKFLVKNTFTEADIRLWTTIIRFDPVYHGHFKCNIKSIQHDYPHILAWARRIYQMEGVSDTVNMVHIKRHYYMSHLQINPTGIVPVGNGPDLTIVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U343</accession>
    <name>A0A162U343_PHYB8</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_146973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
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                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
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    </dbReference>
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    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146973"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="295" mass="33321" checksum="BD5F15825926A388" modified="2016-07-06" version="1">MPTPNCRLTPSLASTDVQLLQALNAMKEEMKAMKDKITLMDTRIGVVITGNATAINGIDALSALPASAHVSTNVASTSAALPITESSDTNAVFGYIHGYMWNPKLKSRDQAEIQANAIKPKWAVDVRFDRSPNRELVKQLLYYLEKKFAGTDMRTRDLRKCIYTNFCSRRRQQRELPETRRALNTNSRRSGRETDNYTRRRLAYDAYKADIDLKMGRNCSGLIQKSVMSEGESDDDIWRSDELNKFITEVDSFVVKQLGANSRQLLKRVYGRTVESTVPIDLDPALPQWALKYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U8S5</accession>
    <name>A0A162U8S5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_111766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292432.1">
        <property type="nucleotide sequence ID" value="XM_018428237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U8S5"/>
    <dbReference type="STRING" id="763407.A0A162U8S5"/>
    <dbReference type="GeneID" id="28989143"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_111766"/>
    <dbReference type="InParanoid" id="A0A162U8S5"/>
    <dbReference type="OrthoDB" id="10044727at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="153" mass="18248" checksum="F3F7A1AC87BEA270" modified="2016-07-06" version="1" fragment="single">MSNWICQQKIEKRTASNVKRYIDHILYPVKFGVVGDISLSSINKYMKTWGFSFRKFTSTVYVDGHKREDVVKYREEWSQQMMTYKKRMEEYSGDNMEVVEEPKVLHGEKKLVLVTHDKSTFYAYDRREKNWLDNKENPLPKKGQGQSIMVSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UAV0</accession>
    <name>A0A162UAV0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_167205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292902.1">
        <property type="nucleotide sequence ID" value="XM_018435592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UAV0"/>
    <dbReference type="GeneID" id="28996498"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167205"/>
    <dbReference type="InParanoid" id="A0A162UAV0"/>
    <dbReference type="OrthoDB" id="2260752at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="758"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="784" mass="86965" checksum="3879E44B09EA77F7" modified="2016-07-06" version="1">MSQQSAVNSTIVSGEETARVNSGVIPPPSAAGSADHDGDTVMTPLCSEDGAFDSEEGSSGSNAGRSGYEGANSHRIYLGNSGVRVDNNLVATVEMLLASAEEDLNTKKGNYYAALGHYLGVSKRDPTSTAAKSASKGAKEAQVLFAEAEQILKDLKASTAPASKPHDKRSTLVPSNLPFLQLRSEGPLVKANRDVFDLVYDFCQEFTTVLEAHSLSLDSCWERLLPTCLNKEERSWFEDKLKGKAYNWKKAESILLDHYDTPFHKFLNMGRVWCMKQGKGESARSFGAKFQKFRCQASLDDGVQLVLCFWWNLRPEVREACLIPLSANYGTKMPSKIEDIISLVSVSTSDSTALLHNPANGTAASSWSSFAAHNGASSLSAGSHKGKKRSFSRERGSQSPKKAWDFKKAMKDGICFSCKAPWVKGHSCPEREKYLTKLSRMAVRSSAGRPARASTVVEGSPSLSWSEYQDNTSALAKMALDCKYNLKDMVIKRDFKNMSTNITFPILANNSIRTISLLDCGATFSSVDKNFCLKNGIVISYINHINKDLLNKNNVHKYFIRLADSNTQIKRIGTCVISVTCNSKTIQREFEVMNLTNSHEYDFSIGTDYMSSLGIGIYGLPLSYDDADSSEERREANRCFNNKSDLLESIERENERKENNPVVGPKQFEDAMDYIRPFIKDNQDIPKGSFCTIPESVVCLDTPENATAFRSPYPIPYKMQGVVDEQEYWQRIGEAPEGIKDINKANKKLLKDMKVAYSAPKENSGTKRKNYAKTAYQKKKRSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UBJ3</accession>
    <name>A0A162UBJ3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ORC6 second cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_144364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293052.1">
        <property type="nucleotide sequence ID" value="XM_018431200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UBJ3"/>
    <dbReference type="STRING" id="763407.A0A162UBJ3"/>
    <dbReference type="GeneID" id="28992106"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144364"/>
    <dbReference type="InParanoid" id="A0A162UBJ3"/>
    <dbReference type="OrthoDB" id="5552484at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054113">
        <property type="entry name" value="ORC6_cyclin-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020529">
        <property type="entry name" value="ORC6_met/pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13394">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13394:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21913">
        <property type="entry name" value="ORC6_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ORC6 second cyclin-like" evidence="2">
        <location>
            <begin position="100"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD75012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="304" mass="33517" checksum="B3913DE09EC9EC2A" modified="2016-07-06" version="1">MAGQNPIAHCLERLFLADDTVLAEKAEHFQGLCSTRVPSKVFGKGPNSKPVISIHLAYENLGRHDWDSKLAAELAGCKPAVYDTAVSLTRKHLGIVPVVSFESLTVALGCTTMIKQVESLWDSFQESYLGNLSVAKKLSAKEELSQPVWKGAIVYACAKALGESVTKAPLQSLCSCSLPELTKCIKVVTDVAKKAIEELKSQSTKASRTPRTTGKRRIGEDEDVVEETPAAKKVKMPGTKKALFGRLKRTDSKQAPATKEYKPISGIVSMINRQDYRQTRRYRDYIQWKDSLIARLSNSTTTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UNA7</accession>
    <name>A0A162UNA7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GSKIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_63258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294573.1">
        <property type="nucleotide sequence ID" value="XM_018441093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UNA7"/>
    <dbReference type="GeneID" id="29001999"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63258"/>
    <dbReference type="InParanoid" id="A0A162UNA7"/>
    <dbReference type="OrthoDB" id="5804279at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2280.10">
        <property type="entry name" value="Hypothetical protein (hspc210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007967">
        <property type="entry name" value="GSKIP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05303">
        <property type="entry name" value="GSKIP_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSKIP" evidence="2">
        <location>
            <begin position="35"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD76533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="153" mass="17050" checksum="CF6BF1A0FAE63464" modified="2016-07-06" version="1">MGMKSLSLTQKLQGISQDYDYGIVPGSSTIFMRDEVNGIARLDLTLLEGVMVIIEVCDQGYKLCSYISLSATPSAFQAGEAIKEHVEVPFESMDNLLMTISPAFRERLERVLFDKLQDIHSDPSLPVTHSPTPHSSSSTKLQDSFDDINDWIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162US66</accession>
    <name>A0A162US66_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_141406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295563.1">
        <property type="nucleotide sequence ID" value="XM_018430590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162US66"/>
    <dbReference type="GeneID" id="28991496"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141406"/>
    <dbReference type="InParanoid" id="A0A162US66"/>
    <dbReference type="OrthoDB" id="2279267at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="519" mass="58927" checksum="65549E3B54912D73" modified="2016-07-06" version="1">MSESGSNDKVPSMSNELPDPKYKEEIASIIFDLENKGVVELSHLLKRLEQRILAKFRPGYCIRRFKGDWIFRIKRTATMLKIKLNKNEDYWPKIEEKLLAIVPDSENSIPSSVLISSDPTSWNRSATSTSSFSSKSSKMSAESTKKLLTADQKLGIEHVFGQLDKTLFWKLSNGVIVEEVMQKARLNCNFEHPCHSFILEIGDHFWETYFSNDELKEINEHGIPAFEEINKDSVEYLDEYLKLNNIDETYAYAFSKMYNPRLHSERSWIQRSVIQAACNFLYNKNMDKFSEADMLGNVWSIFTSVVEGSDINANSGEKSCVSNASVKNSKRSLDAISPTIKRRMGRKVDVIFSEGDIELGLIELGKSNDQTKSLSDGMKLMKLMKDTLVATTDQLPVITHKLRTVGFLLVGTKATMLSMDIPAGYVSRVRKMKPLYYPTNARQFTNRLIPILKLALKAKSTMIHTRNLYDNVTIEESPEEPITSGKQPACSQNTIFSEDTYTLSSCISISEKVKKQKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162USV3</accession>
    <name>A0A162USV3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_76520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295872.1">
        <property type="nucleotide sequence ID" value="XM_018443166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162USV3"/>
    <dbReference type="FunCoup" id="A0A162USV3">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162USV3"/>
    <dbReference type="GeneID" id="29004072"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_76520"/>
    <dbReference type="InParanoid" id="A0A162USV3"/>
    <dbReference type="OrthoDB" id="2257279at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF105">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="104"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD77832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="337" mass="38681" checksum="7D7825D549B85077" modified="2016-07-06" version="1">MATNRSLLQTQTLFRITFYFSSSFLMGNRFSKKSHDTIIEEATSEDKENIQSDIQIEMENSTDDDIMHFIQTAEEREHGQHYLLKHVVQANHFAPIENALKIEGSRALDIGCGSSGVWILDMAADFTNTTFYGIDIIDSFIPQGEKHSFAPTNCHFQTQDVIHGIPFPDNTFDYIHQRFMYMVYPSSMTGWGIKEMKRVMKPGATIELIEYDLRPRQPGPLFTKLFSAVNCALYKINKSGFRGEILGEILKRGDFNDITTDYWSLPICWGGEVGKTMYISVLGVCVWLGSKVYDQLDLQGDNLEESYDRFLDKAFDECVEYQTYFNLHWAYGTKPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V4B3</accession>
    <name>A0A162V4B3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted coth spore-coat protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_139856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297882.1">
        <property type="nucleotide sequence ID" value="XM_018430292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V4B3"/>
    <dbReference type="STRING" id="763407.A0A162V4B3"/>
    <dbReference type="GeneID" id="28991198"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139856"/>
    <dbReference type="InParanoid" id="A0A162V4B3"/>
    <dbReference type="OrthoDB" id="10267127at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050">
        <property type="entry name" value="INNER SPORE COAT PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050:SF1">
        <property type="entry name" value="INNER SPORE COAT PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="65480" checksum="75622B4C3E61EBCC" modified="2016-07-06" version="1">MLCNLCNSLVLIHCTSYIAVFAVFAVVSAAKAKDQITYSVISLEGGRQDISVVVDTISYPLLQSAQVPVLYTGSAPIASKDYKYSMSTGRNSMKTENFSRNKTEESTPNETFGRPWNTRVLSKLKSALPPIPSIDRIKSLLHIDGEIATIHLSGNQSAFDNMHNNPMEESLVAANVSYISPHGIHTFSNVELEISGLSSRTFRKLSYNIKLKKKAKNHLYGYRRLKLRAINNDDSYIRESIGYDIVKAAGLAATEFSYVRVIMNDRPLGLFGLIENYKDPWLSNEFANGNVKYEQGILYQAVYQVDNGNVNITLSDLSYYQNITKYETGAYKIKADSTNGIASLDPLIEFTKFIKDAPTDTPNAVHIWNKKLDTESFLRCIALEILLGFSDGYIGTGNNYYLYLDPKTQRYIYLPSDLDLIFGAGFISTVSMTTGNYSDFPCFHLRPLIAKMMQIPTFKTRLEELIVEITKRLYNLKELENRIDDVVDMIEEDVAWDCSLPRVSKGLILGDIDGSEEYSLSLIPPMVDIPTALNLFTKNETIPLRVAVNGPTGHLASPGVKEFIKWQSENTMEFWHNTTGEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V573</accession>
    <name>A0A162V573_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translational machinery component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_103712</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298113.1">
        <property type="nucleotide sequence ID" value="XM_018427781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V573"/>
    <dbReference type="FunCoup" id="A0A162V573">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162V573"/>
    <dbReference type="GeneID" id="28988687"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_103712"/>
    <dbReference type="InParanoid" id="A0A162V573"/>
    <dbReference type="OrthoDB" id="1654884at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD80073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12061" checksum="FA3E682E58A11684" modified="2016-07-06" version="1" fragment="single">LHINATFNNTILTLTRPNGSPLVNTSGGTAGFKKAQRSGYEAAHQAALQLLDKVQAKNLNVTNIHIVLKGFGPGRDAAYKALVTGVQWNVRRITDATPVPFGGCRPKKARRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V6U6</accession>
    <name>A0A162V6U6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_161064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298462.1">
        <property type="nucleotide sequence ID" value="XM_018434338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V6U6"/>
    <dbReference type="STRING" id="763407.A0A162V6U6"/>
    <dbReference type="GeneID" id="28995244"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161064"/>
    <dbReference type="InParanoid" id="A0A162V6U6"/>
    <dbReference type="OrthoDB" id="5545891at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617:SF3">
        <property type="entry name" value="CORE-BINDING (CB) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47823">
        <property type="entry name" value="lambda integrase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="469"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="503"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="531"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD80422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="894" mass="99780" checksum="A22C8FF3CFD48B82" modified="2016-07-06" version="1">MTNDIHDTLQALLARMEALEARSAAPPVALDGSSADEDDTMLPTDHIVERPIASDLTPFPELIKAIPGMERDFFRQPLDEASRRRFLLNCPRNVLRQYQAPVLNYSGVGTHTKRTDAQLADIQFRLSGLTRPIDLFAHDVLVEGSIQVTQALGFANTMHELLSDLASVVTQMRSDNICRDANLPITPIVTNSALEPKPLLDSQRIVEQAKLQRALHDAARPSRTRKGKRTGQPNRTNKPTQSDPTFAIPSPTAVQVSDNQYTTVGGRLQLFRNAWTKLTNEHWIRRTVEQGYDIPFTRLPPISSSGPLTNHNWMDSNVIEQEIMSLLCKKAIEEQGYDTNHPSLQVERYPERSISPSPQPDNHLETAFLVHRQGPDNHFGSPSRAPANPATDIHTQPSLVPRIAMDQSDTPLFHGSAGTSVVDRPAEGMEWTLVPPRTSDVHGMEMGSASICDGRTFCTLDNLASPISLSAVEPTSPHTAETTTREGSRYVDNAQLVERPLVSSPPPAVVPPANPHPSSPGPSRTRLRRPRSPEEPTLEHDRVGHKLRRLEDQGFDDNANIIILNRDRNHSRRSYNRIQRAYIDWAHHHDVDPFIPNPVHIVNYLAYGATHLKWKASTCQAYRSAILDLYSDKDSIVKDSTYIEFFSALNEQNLLSFHRPTYDIAPVIRFIHNLGPNDTMNAIDLTRKLCWLLAICGFLRPADLERVDDRRTSRDNGILRLVIVAPKEKRSGRRIERVVAIQPHEDPLLCPVATYLAYKSNIAFSVCVRPHPVLSQVTLQRLVRDVRNYDRPIGSERISKHIQFLMEKIPRPSGALLPKARALGPTLALASGASVEDILVHGSWASSAVFDTFYRLSRQTVSNFSTMTLTSSSGYLGTQPESLAVPSLPFPSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V8U9</accession>
    <name>A0A162V8U9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_94085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298892.1">
        <property type="nucleotide sequence ID" value="XM_018443847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V8U9"/>
    <dbReference type="GeneID" id="29004752"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_94085"/>
    <dbReference type="InParanoid" id="A0A162V8U9"/>
    <dbReference type="OrthoDB" id="2276543at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD80852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="98" mass="11459" checksum="780B3260B84185A2" modified="2016-07-06" version="1" fragment="single">PEQFFSDDEYVLADAGYKAMNYIVPIKKKPKNSELSLADQEFNTKISSMQIKIVHEFGILKERFYSLKSISVRIKRKEDIVKVNTWIQVCVDLNNFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WMV4</accession>
    <name>A0A162WMV4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_149546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287185.1">
        <property type="nucleotide sequence ID" value="XM_018432294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WMV4"/>
    <dbReference type="STRING" id="763407.A0A162WMV4"/>
    <dbReference type="GeneID" id="28993200"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149546"/>
    <dbReference type="InParanoid" id="A0A162WMV4"/>
    <dbReference type="OrthoDB" id="5239630at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019034">
        <property type="entry name" value="UPF0390"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09495">
        <property type="entry name" value="DUF2462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="93" mass="10277" checksum="1189B1D6257AC39D" modified="2016-07-06" version="1">MAQKALTKAASPAKKSKNAKTKPIKLRKGCKVIAPKQSILVKQRSMERKMTAKINKNIEKQMSVKANAVGKLTIMKTLAEAAAEEDKKDKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WXP8</accession>
    <name>A0A162WXP8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_66365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289415.1">
        <property type="nucleotide sequence ID" value="XM_018441632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WXP8"/>
    <dbReference type="GeneID" id="29002538"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_66365"/>
    <dbReference type="InParanoid" id="A0A162WXP8"/>
    <dbReference type="OrthoDB" id="10420092at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="157" mass="18372" checksum="385FB0175B64DB2B" modified="2016-07-06" version="1">MDTQPDNVTPDSPDELQNRREDAEPSVIRLLERLNNSMDILVRQNREMLSLIESRGGELFRRKNGPRFQTTEVEPPTTIALSDPPPTIKAWACDMERYLMFYGYSVEQSLLVIPSYMRICYKIWFYDYCKENTPVTIQQIVSDIVKVIYENVIDDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WYP1</accession>
    <name>A0A162WYP1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Asparagine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Asparaginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHYBLDRAFT_187602</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289625.1">
        <property type="nucleotide sequence ID" value="XM_018439400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WYP1"/>
    <dbReference type="FunCoup" id="A0A162WYP1">
        <property type="interactions" value="676"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162WYP1"/>
    <dbReference type="GeneID" id="29000306"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_187602"/>
    <dbReference type="InParanoid" id="A0A162WYP1"/>
    <dbReference type="OrthoDB" id="1931232at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04323">
        <property type="entry name" value="AsnRS_cyto_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000151">
        <property type="entry name" value="Asparagine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000040">
        <property type="entry name" value="Asparagine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1910.20">
        <property type="entry name" value="asparaginyl-tRNA synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048952">
        <property type="entry name" value="AsnRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF16">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20917">
        <property type="entry name" value="AsnRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="269"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="71"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAD71585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="566" mass="63938" checksum="2FD40C92088637F0" modified="2016-07-06" version="1">MTTNISESAQKLSLVDTMYVDEITGSDDTGKGSETAPFKTVLKALETAGETAKVLVKKDADGYKDASGAAIKKAKKTIAEQLKKRQKQEEQKKKQEAELKKKVEEEAKAIEYAKSVVLVEDNSLPKAQKIKVKQSIESRGKRVKVSGWVHRLRVQGKDMMFVVLRDGTGYLQCVLTGKLCHNYDAITLSVESTITVYGVINALPEGKTAPDNHELVVDFWEVVGKAPSGDDAFNNKVTQDADPSFLLDSRHLVIRGETQSAVLKARAQVIKAFRAHYDSRGYTEVTPPCMVQTQVEGGSTLFEFNYYGEKAYLTQSSQLYLETCLPSLGDVFCLAESYRAEKSHTRRHLSEYSHLEAEMAFLSFDDLLESLEDLLCDTIERVMADEPTRKLVEQLNPNFKMPERPFMRMKYADAIEYLRANDIKKEDGSYYVFGEDIPEAPERAMTDKINRPIFLTHFPAEIKAFYMQKVPGDRRVTESVDVLMPNVGEIVGGSMRMDNREELLEAYNKAGIDPTPYYWYTDQRKYGTTPHGGYGLGVERFLAWLLNRHTVRDCSLYPRFTGRCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XEI6</accession>
    <name>A0A162XEI6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_144813</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292405.1">
        <property type="nucleotide sequence ID" value="XM_018431299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XEI6"/>
    <dbReference type="GeneID" id="28992205"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144813"/>
    <dbReference type="InParanoid" id="A0A162XEI6"/>
    <dbReference type="OrthoDB" id="5945905at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007840798" description="DDE Tnp4 domain-containing protein" evidence="3">
        <location>
            <begin position="31"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="83"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD74365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="274" mass="31316" checksum="4A6EC077A8FFF15F" modified="2016-07-06" version="1">MTLALMIVLRRMVFPACLVDLSLLFGKGKSTLIVIFNEIIEKIYIKFYPVLKFDYCQFWESNLMRFSQAIRERPPAMYCVGFIDGTFNKIARPIVDQEGAYNGHYRGHGLKYQAVVTPDGITSFIMGPDNGRNHNVCMYRESQLDAMMCIAFNFTNINGPCYYLYGDPAYTASDHMMIPFRRQTADEQELAINKSMSAVRISVEHKFAHVGSLWAFLKYSQTQRSGRSPVGLYYIVGTFLKNLHVYYNGGNQTSKKYGVAPPTPEQYIYGLLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XQU7</accession>
    <name>A0A162XQU7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHYBLDRAFT_177210</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">In the C-terminal section; belongs to the AIR synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the GARS family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294255.1">
        <property type="nucleotide sequence ID" value="XM_018437863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XQU7"/>
    <dbReference type="FunCoup" id="A0A162XQU7">
        <property type="interactions" value="752"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162XQU7"/>
    <dbReference type="GeneID" id="28998769"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_177210"/>
    <dbReference type="InParanoid" id="A0A162XQU7"/>
    <dbReference type="OrthoDB" id="2018833at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000006">
        <property type="entry name" value="Phosphoribosylamine--glycine ligase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000006">
        <property type="entry name" value="phosphoribosylamine--glycine ligase, chloroplastic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000001">
        <property type="entry name" value="Phosphoribosylformylglycinamidine cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000018">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.600.10:FF:000001">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000019">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="entry name" value="Phosphoribosylglycinamide synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520:SF12">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01209">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="16">
        <location>
            <begin position="115"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAD76215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="790" mass="83738" checksum="45051DF76319C27D" modified="2016-07-06" version="1">MRMVEKLTVLLVGAGGREHAIAWKLAQSEKVSHIYVAPGNGGTSLGSKVTNVAIGVCDFAKLTEFAVKNKVDLVIPGPEQPLVEGIHTAFKKVGIPCFGPSAKAALMEGSKTFSKDFMKKHNIPTAAYENFTDFEKAAAYVKSVKHNVVLKASGLAGGKGVLIPANKEEALAGLKSIMVDKEFGAAGNEVVVEECLEGEELSVLAFSDGYTVIALPPAQDHKRALDGDKGPNTGGMGCYAPTPIGTKSLIDQIKRTILQPTVDGMRRDGFPFVGMLFTGIMLTASGPKVLEYNVRFGDPETEVVLPLLSDDTDLAEVMMACVEGRLDAVSITIKHAFAATVIIAAGGYPGSYPKGQEINIGTLPKDVTVFHAGTESKNNKLFTAGGRVLAVSAVSSSLSEAVDLAYAGVNSIKFDKMHYRKDIAHRAFGYADKLAKEVGLSYAAAGVDIDAGNLLVQKIKPLVKSTKRVGADSDIGGFGGLFDLKAAGFHDPILVSATDGIGTKLKVAQICNIHNTVGIDLVAMNVNDLIVQGAEPFFFLDYFACGKLEVDVATDFVAGVVEGCLQSGAALVGGETAEMPGLYAVGDYDGAGFTVGAVERSKILPRMDTIRAGDVVLGLASSGVHSNGFSLVRKIVDSQPGLTYHSTCPWDKAKTLGEALLTPTRIYVKQLLPVVRNELVKAMAHITGGGFLDNIPRVMPEDLAVVVDAASYELPPIFKWLKQAGNLSPYEMSRTFNCGIGMVIVADRASVPEITRLLEESNEKVVELGRVVTKAELGGKEVEVRNTEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XRX7</accession>
    <name>A0A162XRX7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_143275</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="7"/>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294335.1">
        <property type="nucleotide sequence ID" value="XM_018430961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XRX7"/>
    <dbReference type="STRING" id="763407.A0A162XRX7"/>
    <dbReference type="GeneID" id="28991867"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143275"/>
    <dbReference type="InParanoid" id="A0A162XRX7"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF26">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007840852" description="Beta-hexosaminidase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="11">
        <location>
            <begin position="21"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="10">
        <location>
            <begin position="186"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD76295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="613" mass="69710" checksum="A78B64186AA70499" modified="2016-07-06" version="1">MKRSLLTLTLLSVAFGQPVFLWPKPQSIQWGDVQLNLGRSFNIRGPDIAVLEDAMRRYTHLIARERWDPVQVSDADNVNPVHASKHLNSLDIEIIDKEAALTFGTDESYTLHISPENTIGTLKAQTVWGALRGLETFSQLVQAKYNDSEGEDEDEDEYAYEDDNDLGFQGLFIPQTPIIINDEPRFSHRGLMLDTSRNYYPVKDLLRTLDAMAYNKMNVFHWHITDSQSFPLVLDSVPELAKKGAYRLHGKKLVYTKQDVRVIVKHAHSRGIRVIPEIDMPGHTGSWAKAFKQFISGIYPLFSTCSDRFFLDPSNSWEKRYAAEPGSGQLNPILKGTYTLVKQVIDEVTALFPDEWYHGGGDEPVYRCWEDAKSVRDYMARNNVTGLDLLNIFLEKELEIINSVTENHLAIPKDVVIQVWKNPVKKAVKAGYKVIASSSNFWYLDCGHGQWSGNDTAVNEQSPPVIKKPLQKALEKYEGSDNYNPSNWGGSGGDWCSPFKSWQRMYIYDITYGLSKEETKYVLGGECALWSEQSDETTLDARLWPRAAATAEVLWSGNYDEDGNKRSVDDAMPRMFDWRYRLLKRGIRAEPLQPLWCGSHPHMCDAAFPAGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XWE8</accession>
    <name>A0A162XWE8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_142351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OAD76845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294885.1">
        <property type="nucleotide sequence ID" value="XM_018430788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XWE8"/>
    <dbReference type="GeneID" id="28991694"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_142351"/>
    <dbReference type="InParanoid" id="A0A162XWE8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="66" mass="7477" checksum="A1E7D5FB19C15E04" modified="2016-07-06" version="1">MDIPTHLGRVIYSAMKAEEDAKSIKELKDFVKAGKAKDMISLNDKLMSFAKYGQEISLKDEKKTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XYZ4</accession>
    <name>A0A162XYZ4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_76361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295415.1">
        <property type="nucleotide sequence ID" value="XM_018443146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XYZ4"/>
    <dbReference type="GeneID" id="29004052"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_76361"/>
    <dbReference type="InParanoid" id="A0A162XYZ4"/>
    <dbReference type="OrthoDB" id="2383741at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007840923" evidence="1">
        <location>
            <begin position="20"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD77375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="201" mass="22475" checksum="579DA378F6627973" modified="2016-07-06" version="1">MKLIQALLIFSLCIAAATAASIQPRAELGEALMMYGYNPPRKNPDYCIGFRITYPTYPGLAFEAGSIQQVAWEVDKDIPHSPNIITRIRIINSTQHNQFVIAENITMYNNEEKDNVGEVGFRIGVEDNTGLYHYRIMANYPGTTVHCVYESVPFMIIQNPYKKHNTVGPAYVAPKTDSAIIWPPSEVENQKRLAAGGEPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y4Z2</accession>
    <name>A0A162Y4Z2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate dehydrogenase flavo protein subunit 3 SDH3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SDHC</name>
        <name evidence="8" type="ORF">PHYBLDRAFT_185171</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296365.1">
        <property type="nucleotide sequence ID" value="XM_018439040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y4Z2"/>
    <dbReference type="FunCoup" id="A0A162Y4Z2">
        <property type="interactions" value="273"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162Y4Z2"/>
    <dbReference type="GeneID" id="28999946"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_185171"/>
    <dbReference type="InParanoid" id="A0A162Y4Z2"/>
    <dbReference type="OrthoDB" id="588261at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01000">
        <property type="entry name" value="SDH_CYT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD78325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="182" mass="19352" checksum="202FC6F93E7EF2A3" modified="2016-07-06" version="1">MMATRSLLQTVAQNPVARSALFRNTAVTSMSVRRFNASPANKEQCAAAESEILRQQRKVRPVSPHLEIYQPQITWYLSGLHRITGAAIGGGFYLGALGYLAAPALGYPIDAATVVSAAASAPVALKVLAKGTIAFPFVFHSLNGIRHLAWDVTKFIDIKSVYTTGYAVLAGTAVGTAYLASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y6T1</accession>
    <name>A0A162Y6T1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_140698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296675.1">
        <property type="nucleotide sequence ID" value="XM_018430447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y6T1"/>
    <dbReference type="STRING" id="763407.A0A162Y6T1"/>
    <dbReference type="GeneID" id="28991353"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_140698"/>
    <dbReference type="InParanoid" id="A0A162Y6T1"/>
    <dbReference type="OrthoDB" id="2211878at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="166" mass="19349" checksum="F28F13DFCC6825B4" modified="2016-07-06" version="1">MTVNKTRNELAEKRHQLYFRQMAIRSKSKLHDVKDVPQGSRAPIEKWDKDVPREENRTVASPGDFNYAGTDNGTVNMTTSILMLLKRLKFHLELFNYYAALSKDSNEDSISLNLSKEEELFLHLPSVTSTKARDDDVGCGYFRQRRYLERRKKYMNAGEKVQLIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y7C6</accession>
    <name>A0A162Y7C6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_140823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296805.1">
        <property type="nucleotide sequence ID" value="XM_018430463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y7C6"/>
    <dbReference type="STRING" id="763407.A0A162Y7C6"/>
    <dbReference type="GeneID" id="28991369"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_140823"/>
    <dbReference type="InParanoid" id="A0A162Y7C6"/>
    <dbReference type="OrthoDB" id="498286at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022036">
        <property type="entry name" value="DUF3605"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020:SF2">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12239">
        <property type="entry name" value="DUF3605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="155" mass="18464" checksum="060C1AC5EC688A2E" modified="2016-07-06" version="1">MTKSDEIIPPEFTDHVHPWEEIRHFVLTNQITSLRRNKADQKIYRDWMTETLPKYKTIENYLLTEKLKFSDSVDGKPNVIILPNDFPYSVDPGIKHVLLWSQVPLSKEYVIQLLEENFGSDKWEWVYFVNPPETQSVRLLPHVHVFMRPHTHTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y7S8</accession>
    <name>A0A162Y7S8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_163939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296885.1">
        <property type="nucleotide sequence ID" value="XM_018434900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y7S8"/>
    <dbReference type="GeneID" id="28995806"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_163939"/>
    <dbReference type="InParanoid" id="A0A162Y7S8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="135" mass="15876" checksum="316AFEA598BA1355" modified="2016-07-06" version="1">MFLDISPKIFSTAKHDHQHDEQPSPKHTMDQKLLSHAAVIDMSKESKFHSFTLYIIRKISFPRVEHYRVESSTHGQENNFLLAQRLSNNLTTPLNQLTMVCKLNMHTHYDNKLVINLNKFGSYWFFASHVYNGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YAV1</accession>
    <name>A0A162YAV1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP synthase subunit beta</fullName>
            <ecNumber evidence="14">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHYBLDRAFT_129919</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="14"/>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297465.1">
        <property type="nucleotide sequence ID" value="XM_018429317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YAV1"/>
    <dbReference type="FunCoup" id="A0A162YAV1">
        <property type="interactions" value="309"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162YAV1"/>
    <dbReference type="GeneID" id="28990223"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_129919"/>
    <dbReference type="InParanoid" id="A0A162YAV1"/>
    <dbReference type="OrthoDB" id="14523at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000004">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="188"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAD79425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="519" mass="55926" checksum="94C01CC1AC9E6859" modified="2016-07-06" version="1">MYISRALGHVASSAFRAQSVNVARAAVQPLGAQASLKVRGYASEAAAPGQIRSVIGAVVDVQFEQDNLPAILNALEVQDHTGGRLVLEVSQHLGENTVRTIAMDGTEGLVRGQKVIDTGAPITIPVGKEVLGRIINVIGEPIDERGPINAKSSRPIHAEAPEFVDQSPTPEILETGIKVVDLLAPYARGGKIGLFGGAGVGKTVLIQELINNIAKAHGGYSIFCGVGERTREGNDLYHEMMETGVIKLEGESKCALVFGQMNEPPGARARVALTGLTIAEYFRDDEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLSTDMGGMQERITTTKNGSITSVQAVYVPADDLTDPAPATTFAHLDATTVLSRSIAELGIYPAVDPLDSKSRILDPRIVGDEHYKVATQVQQILQNYKSLQDIIAILGMDELSEEDKLVVERARKIQRFLSQPFAVAQVFTGYEGRLVPLQDTIRSFKEILDGKHDGLPETAFYMQGDINDVIKRSEELAKEMGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YBH6</accession>
    <name>A0A162YBH6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MINDY deubiquitinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_184800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297575.1">
        <property type="nucleotide sequence ID" value="XM_018438991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YBH6"/>
    <dbReference type="FunCoup" id="A0A162YBH6">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162YBH6"/>
    <dbReference type="GeneID" id="28999897"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_184800"/>
    <dbReference type="InParanoid" id="A0A162YBH6"/>
    <dbReference type="OrthoDB" id="10261212at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016807">
        <property type="term" value="F:cysteine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007518">
        <property type="entry name" value="MINDY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033979">
        <property type="entry name" value="MINDY_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063">
        <property type="entry name" value="NF-E2 INDUCIBLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04424">
        <property type="entry name" value="MINDY_DUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MINDY deubiquitinase" evidence="2">
        <location>
            <begin position="81"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD79535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="479" mass="53518" checksum="C0FA17B33D1CFADD" modified="2016-07-06" version="1">MTDTAPLDNQSSHSIDAIARCLEEAKIASEQNNETSLPLEPTDPSHPDSLTPPLIHDSAEHTQDTQESSHRQSRIIVPAQEYLVKTIDWYSHDKKQKQIIRIVTQNENGPCPLVAICNVLLLREEITILPPDREMVTFEYLIERLGDYLLNHGPAEQKFQAKRGDIPTSPSSLSLSNELILSDHESEAKPSKMITRQSTTEHVATYRYNLDSALSILPNLQTGLDVNIGFSSIRDFEPTEELAMFDLFDVDLIHGWVADPQDSQTFDLVTKCGSYNSVVECIVQGDAISSELDNPDNQKVLSPEAERSITEGLVAASFLQDTATQLTYYGLQLLMDSIPKNKLCVLFRNNHFSTLYKHPETEGLYTLVTDSGLVKERSFVWESLADIDQGASEFFDGLFNKPFLESTQDADRGRISDMDLAIALSLEDQRNTEIALSNNDLVEPLKPTPVKEPSSKRASQLTMASTESTKKKRQSCNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YI81</accession>
    <name>A0A162YI81_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_102202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298905.1">
        <property type="nucleotide sequence ID" value="XM_018427684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YI81"/>
    <dbReference type="STRING" id="763407.A0A162YI81"/>
    <dbReference type="GeneID" id="28988590"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_102202"/>
    <dbReference type="InParanoid" id="A0A162YI81"/>
    <dbReference type="OrthoDB" id="3039677at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="177" mass="20247" checksum="E70660292B488B6E" modified="2016-07-06" version="1" fragment="single">NLPREERFKPENVILVGLMPGPKEPKTEEINHYLKPIVDELLQLFTGITIPTFECPASVNIRAALHMVACDIPATRKTSEFTAHNSTCACPRCVRQFTRLPSTNQVDFSGFDYSTWKIRSGLENRLHAEEWKSASTPSERHQLEIENGVQWSQLHRLGYFDLIRGMIIDPMHNLFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZDY4</accession>
    <name>A0A162ZDY4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_73141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441005">
        <property type="protein sequence ID" value="OAD66131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284171.1">
        <property type="nucleotide sequence ID" value="XM_018442792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZDY4"/>
    <dbReference type="GeneID" id="29003698"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73141"/>
    <dbReference type="InParanoid" id="A0A162ZDY4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="101" mass="11166" checksum="4ED7672BC615A491" modified="2016-07-06" version="1">MESISSFTAKTSFYLCQGVQRARAELINILIGGECLVKIWSRLRVLEQASLVFFGDSSSPDKDPVILCSKMQTGNSCNEMSFTEANLRLNSFLVCQSCGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZM98</accession>
    <name>A0A162ZM98_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_72192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285821.1">
        <property type="nucleotide sequence ID" value="XM_018442612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZM98"/>
    <dbReference type="GeneID" id="29003518"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_72192"/>
    <dbReference type="InParanoid" id="A0A162ZM98"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="109" mass="12365" checksum="A2E494C0AB6A78D4" modified="2016-07-06" version="1">MSCLNRDGLNDFQFAPLILSVSQNFSGPLTKTYTLGGFTKCHWSLSRSSFFDYTPTLILYRQTNNVIVFCVCQLFCFLNCLAKKACRSKQWNTVGVDCTRGGPMDVRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZVI3</accession>
    <name>A0A162ZVI3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Diphthamide biosynthesis protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_149681</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DPH4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287321.1">
        <property type="nucleotide sequence ID" value="XM_018432315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZVI3"/>
    <dbReference type="FunCoup" id="A0A162ZVI3">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162ZVI3"/>
    <dbReference type="GeneID" id="28993221"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149681"/>
    <dbReference type="InParanoid" id="A0A162ZVI3"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45255">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45255:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="3"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="DPH-type MB" evidence="8">
        <location>
            <begin position="79"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD69281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="139" mass="16220" checksum="3745FD080DECE848" modified="2016-07-06" version="1">MENHYTVLNISESATTDQIKLRYKELILKHHPDKHTANTLDDGDYAHRILKAWETLRDAKKRQNYDAELKANRFQQPAINAEVDLDDMEYDEETCTFSIECRCSGIYAIKEDDMEQGIDVVCCDLCSLRIRVLYDVLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163A2I7</accession>
    <name>A0A163A2I7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_33326</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288661.1">
        <property type="nucleotide sequence ID" value="XM_018440011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163A2I7"/>
    <dbReference type="FunCoup" id="A0A163A2I7">
        <property type="interactions" value="619"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163A2I7"/>
    <dbReference type="GeneID" id="29000917"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_33326"/>
    <dbReference type="InParanoid" id="A0A163A2I7"/>
    <dbReference type="OrthoDB" id="1724687at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047861">
        <property type="entry name" value="Ribosomal_eS7_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00948">
        <property type="entry name" value="RIBOSOMAL_S7E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD70621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="194" mass="21641" checksum="002531E1AEFC696A" modified="2016-07-06" version="1">MASHKIAKLSGASPADEFELSVAQALLDLQNNVPELKKDLAGLQITGAKEVELGAGKKAIVIFVPVPSQKAFNKVQARLTRELEKKFSDRHVVFVAQRRILSKPTRRQNPKQPRPRSRTIKAVHEAILEDLVYPTEIVGKRTRVAVDGSKTIKVFLDTKDATSLEYKLDTFSSVYKKLTGKNVVFEFPANVDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AVI0</accession>
    <name>A0A163AVI0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_158216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294141.1">
        <property type="nucleotide sequence ID" value="XM_018433753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AVI0"/>
    <dbReference type="GeneID" id="28994659"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_158216"/>
    <dbReference type="InParanoid" id="A0A163AVI0"/>
    <dbReference type="OrthoDB" id="2338663at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044819">
        <property type="entry name" value="OBL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46086">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46086:SF3">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE OBL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="194" mass="22170" checksum="D6EC7973FF08EAE9" modified="2016-07-06" version="1">MLQSKSPLLEHFSGMYTYGQPKIGDAKFSRIFSTQLTNKIFHHAYNNDIVTRTPSWFHYDTPPGTLVFIDSAYNITLYPPNPYTNEPVPVRPISFVHLSGILNHYVIKRLSGETWIRIIFRFAFPFCLNDHFPSEYCEGLRHGTVNWVIMAAGGIQGGYRDDKRTVNRPRKSFSAVNVQNSASNINMSPREPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B3K9</accession>
    <name>A0A163B3K9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_164995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD78121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296161.1">
        <property type="nucleotide sequence ID" value="XM_018435130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B3K9"/>
    <dbReference type="GeneID" id="28996036"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164995"/>
    <dbReference type="InParanoid" id="A0A163B3K9"/>
    <dbReference type="OrthoDB" id="2289470at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="326" mass="36070" checksum="7C38B33738064173" modified="2016-07-06" version="1">MSTLTDLSSLDLAFLFWHLNSHYTAVNAQEDITVHKEVLQLSFLIWDGLPFTIAKSKGQTHWGSESIFCIHTILSSIHPKYCFNHCIYCQTQRIYPSHHRIHCQKIFSIVPATLSPIFTFSLPIATISRSLPNMLQLLPANCMQSLSAELVTFLTSMQSQFNALNKRTTYLESLAAENVQLHAQLANVRQENADLQSQLLQNNVTGSVSSSASLPAPQSTADLGTAAFTWATKTSLIFEVHHSLHTLGVDTGRLLDINFPACKVIGVLVHVQYLKEFKSQLASAKVSLVNNFNPLDPKNVADPKFANLSVSGLETQALVLQNAHCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B808</accession>
    <name>A0A163B808_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Post-transcriptional regulator MKT1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_157638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296791.1">
        <property type="nucleotide sequence ID" value="XM_018433654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B808"/>
    <dbReference type="STRING" id="763407.A0A163B808"/>
    <dbReference type="GeneID" id="28994560"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157638"/>
    <dbReference type="InParanoid" id="A0A163B808"/>
    <dbReference type="OrthoDB" id="17262at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022039">
        <property type="entry name" value="MKT1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12246">
        <property type="entry name" value="MKT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Post-transcriptional regulator MKT1 C-terminal" evidence="1">
        <location>
            <begin position="66"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="306" mass="34346" checksum="F20AE16EB8398ABA" modified="2016-07-06" version="1">MTSSWNVTKELIENEKAEQHGSTIDVSFCIRATENEAKAAKTVSKPSSGKILHIKDEIVANVLWKTLEIRDFLTSSKHIHTPWGRALSVALTNISKTMGVQPTMSTQEAFLTAFELIRFDVLTNKPYSKTYSTIAGDEKEQCHIRLISRALSLLPMELKSAPWSGPFNRDLLVFNSFVKALDRSYRNLCEMLTLSLFLNNGVVKEQKDYFEIADSLPYMSDANVTLGLVTKHYLEQIVTGRDPASATQSAEKTFLSCTALAADLRRGLLFWDALVKGTKVLKDAGSLSNESYQAFYQANQWLQNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BCW6</accession>
    <name>A0A163BCW6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_138256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298751.1">
        <property type="nucleotide sequence ID" value="XM_018429961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BCW6"/>
    <dbReference type="GeneID" id="28990867"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138256"/>
    <dbReference type="InParanoid" id="A0A163BCW6"/>
    <dbReference type="OrthoDB" id="2273778at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="450" mass="52982" checksum="BD6BAF1C781CED38" modified="2016-07-06" version="1">MAPSKTNKRKRSKKDTSDNHYTDVRWCFENKDNLNFTAFADHFTLTDKQFAYNRYMRILKKYIKVKALEANFEIWRKSDFADDYWTKRLRSSTARKSGRKAAEHVHKAIINEYAQLDEHLEGESALSDTTTDGSDYIESEQHFVYWLTFDELNDKSLKRSSSKYVLNKKQSTFNQRLGLSSITLIPAEEMFTLKRHSLNDDCYLMVRQFKRAVEESKLSIPADWSQSSDSLRPLLYCVLTYTLNIINIDRKHEHTKQDIVRKSEPNFISKYVANFFQNIMFAYQDSLFFRWDTCSEVYDESKKKKRPDFIICTFDGFEVGCGEIKQPGTNYNDVEEDRCRVPEQLKKQLHKRLQTASEEKELATFGCFVFGEELELSMMEFKQGRYEYSVIKKLKLPTMCSTFERMDQSLEFLLGFFDIIKNTIVGKDGPVDSSLFLKYKQLLKPTISFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DHB0</accession>
    <name>A0A163DHB0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_147674</name>
        <name evidence="2" type="ORF">PHYBLDRAFT_147715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289206.1">
        <property type="nucleotide sequence ID" value="XM_018431930.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289250.1">
        <property type="nucleotide sequence ID" value="XM_018431933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DHB0"/>
    <dbReference type="GeneID" id="28992836"/>
    <dbReference type="GeneID" id="28992839"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_147674"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_147715"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="54" mass="6033" checksum="DF703A6D681C900E" modified="2016-07-06" version="1">MSFCKLMVIGRPSWLLCTNDDQPETDQCITRNLPLSHPVGAASIKKRKEGSMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DLU9</accession>
    <name>A0A163DLU9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_147182</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290250.1">
        <property type="nucleotide sequence ID" value="XM_018431807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DLU9"/>
    <dbReference type="FunCoup" id="A0A163DLU9">
        <property type="interactions" value="446"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163DLU9"/>
    <dbReference type="GeneID" id="28992713"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_147182"/>
    <dbReference type="InParanoid" id="A0A163DLU9"/>
    <dbReference type="OrthoDB" id="442863at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012590">
        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06978">
        <property type="entry name" value="POP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08170">
        <property type="entry name" value="POPLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pop1 N-terminal" evidence="5">
        <location>
            <begin position="136"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="POPLD" evidence="6">
        <location>
            <begin position="488"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD72210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="784" mass="88746" checksum="A3588482F3DFF68C" modified="2016-07-06" version="1">MSTSGSNKRPAQEPLSSKAQNKKSKEQGNSTSISTAGFGNYGKNILSQNALRVTGAIDTKQFVIARLPEMNAMQSVIKETRWKGLPPQLRAHRRRAASYKLTGFSAMSRAKISSKRGRMFIKGKKPLRTMFQLKPTVYAKEYLYKQSNKKWLETHMWHVKRMKMVNIWGHRLASHPNMKSSRIFYRAFTQAAVIHDASYESCVELSGASKQIVRILNTITDPSLPSVGSARYNKGQRMGKTYLYEYMQYPTNLICPIEYLWRPSKVEGEQGMIWVWIHPSAYTEALCTLKEAIKHGNEKSTENIQICEQKEKLVRFNLAGPHSTALLQSIFRPIEEAEVQIERANTTEQTQLWDDIGSLKSACSLSPDVIIGLTVQDPRLKFPQLKRPQIHEVSNEVEARLSTLIREWPIDVAYSDIWESTSRQASLDSKVSEYALNKRREENVVPGTKLVFTEKDSRIPILLVCRTCPVVDDSTIQTSTSVSSRIESWSIILPSGWGMPFWTSLLFAGAKPIGLENVRSLALETGQCCFPYDYPSTRAFAAQKAQMEEANLKKWLSRPPAKRENFKRIGVDHPFAAQFDTLFRKNGSTDDVLDCVPKPNYSLIQGARMISSIATSSSETSSQAALEKAVIECLSKRSLNILSSVSLNSTLVKVRVKYIEKKVPFPNALVYLIENPDDYMRHTWYIRNRMPVHQSKKDIKLSLKNETMSDTTLDEKHHVLPSSQQIGYITNGAFSLMHGCGIDRLNYNYFAKSDNIIINQVANTTGVKSVFKMFFSILSVSPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DMX1</accession>
    <name>A0A163DMX1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_159150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290470.1">
        <property type="nucleotide sequence ID" value="XM_018433925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DMX1"/>
    <dbReference type="STRING" id="763407.A0A163DMX1"/>
    <dbReference type="GeneID" id="28994831"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159150"/>
    <dbReference type="InParanoid" id="A0A163DMX1"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31964">
        <property type="entry name" value="ADENINE NUCLEOTIDE ALPHA HYDROLASES-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31964:SF140">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="29"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="177" mass="19682" checksum="49423332D85B4D19" modified="2016-07-06" version="1">MATEAHHDVTLHSDHPELDTEGQHIDRVVFVCIEEKSGHSVLNWAVKQFIRPESDLVVLIHVRPIDIPSAPYMNTTSSGQEVPDIRREESHKMLREFAHELVSKKITCKAVSMIGDPKSEIVRKVIETKADVLIMGSRQLGAIKRAFLGSVSDYCAHNCPCTVVIAKTADTVESEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DWY2</accession>
    <name>A0A163DWY2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_95168</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291950.1">
        <property type="nucleotide sequence ID" value="XM_018443885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DWY2"/>
    <dbReference type="GeneID" id="29004790"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_95168"/>
    <dbReference type="InParanoid" id="A0A163DWY2"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="3"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD73910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="59" mass="7090" checksum="964A2596EA567CFD" modified="2016-07-06" version="1" fragment="single">RMRATPKQLELLEKTFSINPSPNNRMREQMSKELAMSERSIQIWFQNRRAKVKNQAKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163E7X7</accession>
    <name>A0A163E7X7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_123162</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295250.1">
        <property type="nucleotide sequence ID" value="XM_018428911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163E7X7"/>
    <dbReference type="STRING" id="763407.A0A163E7X7"/>
    <dbReference type="GeneID" id="28989817"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_123162"/>
    <dbReference type="InParanoid" id="A0A163E7X7"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF85">
        <property type="entry name" value="DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G15880)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="306"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD77210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="37479" checksum="85298E1399ABB661" modified="2016-07-06" version="1">MLQEKYIGLTLAMCSSVFIGLSFIITKKGLINSKRRHGNAAEEGGHYYLRNWTWWAGMGTMAVGEILNFSAYSFAPAILVTPLGALSVILGAIFASLFLREKLGAIGKIGCLLSVIGAVIIVLHAPEDKEVTSIDELLFYALQPAFMTYCAMVVIVSLIMIYLVVPRYGKKNPFVYISICSLVGSVSVMSIKAFGIALKLTFAGNNQFTHPSTYAFGIVVIVCIITQMNYFNKALDQFSTNVVNPIYFVMFTSSVLVASAILFQGFNTDNTVNVVSLICGFIIIFAGVYLLDSIARGAGAGGGGGGGVGDHLGSPEEQGFLMGEDEEDAMGLTDLSASDEERLRRSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163E9C7</accession>
    <name>A0A163E9C7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COP9 signalosome complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_108077</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. CSN5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295510.1">
        <property type="nucleotide sequence ID" value="XM_018428028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163E9C7"/>
    <dbReference type="FunCoup" id="A0A163E9C7">
        <property type="interactions" value="834"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163E9C7"/>
    <dbReference type="GeneID" id="28988934"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_108077"/>
    <dbReference type="InParanoid" id="A0A163E9C7"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000003">
        <property type="entry name" value="COP9 signalosome complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040961">
        <property type="entry name" value="CSN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18323">
        <property type="entry name" value="CSN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="11">
        <location>
            <begin position="53"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD77470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="339" mass="38601" checksum="D0E6C9AD7C846BE9" modified="2016-07-06" version="1">MDAENARKNWELENNIQTVDPAKDQIYYYDAQLDKDNVAQQPWKTNPNHYKYVKISAIALIKMVMHARSGGNIEIMGLMQGKVQGNTMYIMDAFALPVEGTETRVNAQSEAYEYMVTYMERAKEAGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQYQEPWVAVVIDPNRTMSAGKVDIGAFRTYPKGYKPKNDDPSEYQTIPLDKIEDFGVHAKSYYPLEITHFKSSLDSHLLEVLWNKYWVNTLSQSPLLTNREYSTRQMTDLAEKLKKTNSSMTGRMGGYYGDRKKNDESQLGKVTKDSTKISVEAVHGLLSQVLKDVVFNQTSQARACGCRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EA28</accession>
    <name>A0A163EA28_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable electron transfer flavoprotein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_131221</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 10">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295620.1">
        <property type="nucleotide sequence ID" value="XM_018429414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EA28"/>
    <dbReference type="FunCoup" id="A0A163EA28">
        <property type="interactions" value="339"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163EA28"/>
    <dbReference type="GeneID" id="28990320"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_131221"/>
    <dbReference type="InParanoid" id="A0A163EA28"/>
    <dbReference type="OrthoDB" id="1715808at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000041">
        <property type="entry name" value="Electron transfer flavoprotein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000001">
        <property type="entry name" value="Electron transfer flavoprotein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 9 10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="11">
        <location>
            <begin position="29"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="256"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="270"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="287"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000089-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD77580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="338" mass="34755" checksum="8C6E6FB10698B967" modified="2016-07-06" version="1">MLATTARIAIQARPFISQRFYATGAGASTLLLVEHKDGLIGGATLNALSAASKLGGSITALVAGDAPEAVAKQVAKYDGVSKVLTATGAAYANGLPESFAPLLVEIQKANGYTHLVTGHTAFGKNIFPRAAALLDVAPISDITGVSSEDTFVRPIYAGNAIATVQSKDAIKFITVRGTAFAAAEANNATEATVEAAPTAETSDATQWLGESIQKSDRPDLGSASRVISGGRGMKNGENFQLLYALADKMGAAVGASRAAVDAGFVDNSLQVGQTGKIVAPELYIAVGISGAIQHLAGMKDSKTIVAINKDADAPIFQVADYGLVEDLFKAVPEMTEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EDY8</accession>
    <name>A0A163EDY8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_73587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD78130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296170.1">
        <property type="nucleotide sequence ID" value="XM_018442883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EDY8"/>
    <dbReference type="GeneID" id="29003789"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73587"/>
    <dbReference type="InParanoid" id="A0A163EDY8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="138" mass="15845" checksum="18F9597ADEA3A1F6" modified="2016-07-06" version="1">MLPFMIINSLNEIGNSMENSNGKWTVKSFTVQRENNHLQLQRLLASEHEVAVVNEKVENETNTVVVSGRNNSVWLQRIIAQNTTLHHQREDLEQLMNVPEIDEAELQVISDLLGEAMNCIDTFRNANSSCFRNHNTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EEN2</accession>
    <name>A0A163EEN2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_157504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296300.1">
        <property type="nucleotide sequence ID" value="XM_018433628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EEN2"/>
    <dbReference type="GeneID" id="28994534"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157504"/>
    <dbReference type="InParanoid" id="A0A163EEN2"/>
    <dbReference type="OrthoDB" id="2281255at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="92" mass="10731" checksum="2EA9AAF63FECEDCC" modified="2016-07-06" version="1">MESHGWINVGYAQKSRTNEPVKNKIKPIQKMTDFLLIKCHCAKVFLSPPPCAPLDRNYANMIQSCQDWIVIDTQSQYYPIIRYCLIKNVNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EH34</accession>
    <name>A0A163EH34_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_62628</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296650.1">
        <property type="nucleotide sequence ID" value="XM_018440995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EH34"/>
    <dbReference type="FunCoup" id="A0A163EH34">
        <property type="interactions" value="239"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163EH34"/>
    <dbReference type="GeneID" id="29001901"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_62628"/>
    <dbReference type="InParanoid" id="A0A163EH34"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="136"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="233"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="96"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD78610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="455" mass="51175" checksum="0099B5E0D1575640" modified="2016-07-06" version="1">MDLENNISFTSISSSLTQHSHEEHLQSHQNTPNHITRRHQLKNHKKLSLSLNLPLENTRSTPPTRYLTDKSELDCAQNLLLNKPATDTNLRNLGSLDSSISNSARPSSSEAGTSFDWNGDISFEEQSHDPDPYREGPAQILPNLYLGASYNAAQDDQLCANKIICIVNVASEIKTPTSQAFDIITQRSPETLQNSQTQLSESTPKTSNISEKASLVQYHHLRWTHAQSNLAYQEFDRAIRIFETYQNGTSGNVLVHCQCGIERSAALVIAYVLYLSYRPAKFNNPAKSDRDNFKNLADKRLSVSEAYEYVRQRAPYIRPNLKLMYQLSDFKESLSLGDIGSLPRPCLSSELYIKRSGSVKAHMSLANGSSAYRRPRSSSLREFRGQPKSFEITKHKQIQMNTLSDTPKGPVLSQEQETPCVPENINQAQSKDDQCIGHSPVVMSPILFRRIFSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ERS1</accession>
    <name>A0A163ERS1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_56387</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkylbase DNA glycosidase AlkA family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299160.1">
        <property type="nucleotide sequence ID" value="XM_018440213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ERS1"/>
    <dbReference type="FunCoup" id="A0A163ERS1">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163ERS1"/>
    <dbReference type="GeneID" id="29001119"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_56387"/>
    <dbReference type="InParanoid" id="A0A163ERS1"/>
    <dbReference type="OrthoDB" id="415889at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032131">
        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000004">
        <property type="entry name" value="DNA-3-methyladenine glycosylase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="5">
        <location>
            <begin position="129"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD81120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="306" mass="34171" checksum="C60EBBBECE31DC32" modified="2016-07-06" version="1">MSLRKSTRTIVRTSTLFYGEKPIPKLATKSKSSMKKNKTAAVTRTTKKLKASSDPSSSNVISAASATTISDEKSAELRTFDIQDAIDHLKVSDPKLAPYMTEESFEYLRKRLGNANTKNPFRALATSIIYQQIHGKAAAAICTRFIKLFDPPVPVPDIVNSDFDWFPTPKIVLDKTLEELKAAGLSTRKAEYIQSLAEKFRDCSVDIDRLQSMSDDELSQFLCSVKGIGQWTVDMFMIFNLGRPNVLPLTDLAVKKAVARHFGLPIGPKKFPTADEMCRVTKIWEPYRTVATLYMWRGSSTVISAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167J7Y4</accession>
    <name>A0A167J7Y4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_176045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441010">
        <property type="protein sequence ID" value="OAD65447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283487.1">
        <property type="nucleotide sequence ID" value="XM_018437630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167J7Y4"/>
    <dbReference type="GeneID" id="28998536"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176045"/>
    <dbReference type="InParanoid" id="A0A167J7Y4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="41164" checksum="404F5F8BBEDF002C" modified="2016-07-06" version="1">MYNILLDSFQTMVNNHQSIAPAPSPEYTELLRRLTAMEESLKTMDSNIGIVIKGNKDSLEILDSVANASGELLAVIAPTTIPASASVPFAASSVGSTLDWYTTPSEAFFGISSAAPSVAPSVAPSVAPSVGPVVLTGANAGELSKQNRTRVLALIRGELKKHNFKSNKPELVAANDSKCSWDFNVDYRLPPNRQLMHDLHAYLAPKVVGTSVRQADISDCIYTNFCGTRRRVKESYEARKKTNSWSRKAGRETDHFDRRELTYHTFKAEIDMKVGKSCDGLLQKEAMSEGESEDDMPGVSSNRAIRTVRPSWRSDEYNHFLAVVDDFMRNRMDFNSHQMLKRSFGRDAVLAVPPRLTSLLPHWAFRDEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167J8V1</accession>
    <name>A0A167J8V1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_176101</name>
        <name evidence="3" type="ORF">PHYBLDRAFT_176104</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441010">
        <property type="protein sequence ID" value="OAD65507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV441010">
        <property type="protein sequence ID" value="OAD65512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283547.1">
        <property type="nucleotide sequence ID" value="XM_018437655.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283552.1">
        <property type="nucleotide sequence ID" value="XM_018437657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167J8V1"/>
    <dbReference type="GeneID" id="28998561"/>
    <dbReference type="GeneID" id="28998563"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176101"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176104"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD65512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26753" checksum="8E9B4C86BB8F8971" modified="2016-07-06" version="1">MPSNSSRKTDRKGKGKASASISTSANRVLAGRVGPREIAPSFSSATIQDQRYVEIVEMLNKTRMASLEPSLMPSYVPQTSLSDAEVSVIISEIFAEKLWDWKFESDDPALVAENESKKKWNLNKKINHRDNVAVINYLKSYISAQTRLAGTHPRVISDKIKNRYKHSHCTFHESPEQKAKKNSKGRANSRTLQLTYMDNWVAIDAAMGYKTGNPVEKAYLKLFQKDAMSDVQQIVDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JAJ9</accession>
    <name>A0A167JAJ9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_175995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441009">
        <property type="protein sequence ID" value="OAD65607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283647.1">
        <property type="nucleotide sequence ID" value="XM_018437619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JAJ9"/>
    <dbReference type="GeneID" id="28998525"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175995"/>
    <dbReference type="InParanoid" id="A0A167JAJ9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007888727" evidence="1">
        <location>
            <begin position="23"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="185" mass="21381" checksum="226F73E0AE3AA0D4" modified="2016-07-06" version="1">MFDFFLHLQFSISLLFQTCVKDLRFLVTEPKKWIKSPSCSFVVKEYTLTLLVSGQFETLSRKKFAPCGTSLQPRQDILLNSIHNGRRLAICPHQLPPKNLFLVIRSPIFSPKFPPFLVNPLHLCPLEIVPRRTDLVWYRCVFWIHKWIVRVSKRNPSLELLSLLKSVPNSGALSSGSQYAKMRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JE47</accession>
    <name>A0A167JE47_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_137566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441027">
        <property type="protein sequence ID" value="OAD65808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283848.1">
        <property type="nucleotide sequence ID" value="XM_018429863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JE47"/>
    <dbReference type="FunCoup" id="A0A167JE47">
        <property type="interactions" value="111"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167JE47"/>
    <dbReference type="GeneID" id="28990769"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_137566"/>
    <dbReference type="InParanoid" id="A0A167JE47"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01838">
        <property type="entry name" value="Isoamyl_acetate_hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="257" mass="29725" checksum="4125DED0E186A4F9" modified="2016-07-06" version="1">MNHPYHKIVLFGDSITQFSFDPLFQGFGASIANAYQRKIDVMNRGFSGYNTTWAIPILRQLLPTVEQQKQPAKIQLLTIFFGANDGALPISFQHVPLEKYKKNLEELISMVRSPSSPYYNPSLRLVLITPPPINEVQWKVVCEENGIQLDRKFETTRLYAECARNVGKEHKIPVINLWDEILDRAKEQNRDLSQFLSDGLHLSSLGNQTAYELFMEVINTHFPELHPDALEMELPYFRDIDPKNYLDALQFKLIQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JLF5</accession>
    <name>A0A167JLF5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_152573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441004">
        <property type="protein sequence ID" value="OAD66248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284288.1">
        <property type="nucleotide sequence ID" value="XM_018432954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JLF5"/>
    <dbReference type="GeneID" id="28993860"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152573"/>
    <dbReference type="InParanoid" id="A0A167JLF5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="80" mass="9088" checksum="ED93D82B169EE543" modified="2016-07-06" version="1">MSRKANMMKQGLQTVFINPFIDNSLLVKELVAGLTNNELEQVVNSVIITDFDCCSEWRHNNPTLAMLNVDLTTSEEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JSY7</accession>
    <name>A0A167JSY7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_152190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441001">
        <property type="protein sequence ID" value="OAD66640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284680.1">
        <property type="nucleotide sequence ID" value="XM_018432864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JSY7"/>
    <dbReference type="GeneID" id="28993770"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152190"/>
    <dbReference type="InParanoid" id="A0A167JSY7"/>
    <dbReference type="OrthoDB" id="2243238at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="607" mass="72244" checksum="FF43E79CF0098839" modified="2016-07-06" version="1">MATDLSEKLLTYLATHVKKKDRLNCSLVCKQWTEPFLNAYWAKVEIGNWNIEKIFDEFGPKEVYQKNAYRVWALDIKLYKHSFKHIQLLQQTYSRIKYLSWRVDLEKLAGGKIDWSIWGTLSHLELSFTGVQLAPETTFEEFSALSCLVHFTIRQELDPKVNIHISLTNIESLHLYLPRLEYINIDFLLQLIPEKEMETIRNVEPAHNITTMEFVSDTLSTLWIFYLAHKYPNIVGLNLRAPKNLRDDDQIPCDDQKYQSQLRILLSLKQFFPCLQKTSTYINNTNLWLIKLFYDALRHFDVKINYIHIDFEDETPEANDINRWISYFSESVNVLYLEQIDQLDKKRKLLVYCHKLTVLNIYLGGYIDIGNILDYCPVLQSLNISSSDIHSPEYPQPTHLPHSLQTLEIQDTKISQHTFKYISFRCRQLKYMKLYHINFHYSGSDETGQLLVDMPFSQLKTLKAYSNTNHSDDSDIYDYIPVKHIVIEQIENVDSNLLSQNNQGQAPQSNWYHLCADRTNRKGRNLAWELGRRDIEFAQRYYKDFQRRRRREKIRKDLNEVLYGYKPKRFWKRDLQGGVLKLRFKSVKDYFLEEKNEYRNIFRPKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JVB5</accession>
    <name>A0A167JVB5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type zinc finger transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_152036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441000">
        <property type="protein sequence ID" value="OAD66766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284806.1">
        <property type="nucleotide sequence ID" value="XM_018432820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JVB5"/>
    <dbReference type="GeneID" id="28993726"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152036"/>
    <dbReference type="InParanoid" id="A0A167JVB5"/>
    <dbReference type="OrthoDB" id="3248986at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="26079" checksum="907166DC066DA2A1" modified="2016-07-06" version="1">MKNNNLLAMQTVAAMMILSSDYTKLKTKIGKDFSHIKADEWKSWILVYSPMLLKPVLLSNIFNGWMHYVKACCVLVKLSISFIEIDQVHRYLQEFCQSCEDTYEPKVLTYNMHLHLHLHDKICDFGPVYDYWLFGFERYNSLLKNNKTNRKDRFETTYMTKFTADAYKADYVRNMLSCPSLIPFLPLFEKLTSTTAPITTYATYAPTNQQSFQSQQFVDSSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JZS8</accession>
    <name>A0A167JZS8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_70351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD66996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285036.1">
        <property type="nucleotide sequence ID" value="XM_018442261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JZS8"/>
    <dbReference type="GeneID" id="29003167"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70351"/>
    <dbReference type="InParanoid" id="A0A167JZS8"/>
    <dbReference type="OrthoDB" id="3247418at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="273" mass="31252" checksum="A615A89059E8E619" modified="2016-07-06" version="1">MPNVCESDIASAHKYREKFCQNCEALHNLDLISPNMHLHFHLQDTICDFGPVYGYWLFSFERYNSILKNIKSNRKTGFELTYARQFVEDVHKQDIISRIMESSDTRAYMDIFQKITKYQQKIASTITSYSHFFFSLANFITATLEVSILIKGNEPLPSTAFPLAKKSLSLMPTPGYNCLIEYYQGKFIRDVMAMDVVRTSKLCFKKIGPMRVMAMSVKFNTSLCTHSPHQQPLSHQLATTTNIPLLSSDGLKQHQIRADNFEALKSTTTTSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KH79</accession>
    <name>A0A167KH79_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Alkaline phosphatase</fullName>
            <ecNumber evidence="2 11">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_156418</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286135.1">
        <property type="nucleotide sequence ID" value="XM_018433488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KH79"/>
    <dbReference type="FunCoup" id="A0A167KH79">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167KH79"/>
    <dbReference type="GeneID" id="28994394"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_156418"/>
    <dbReference type="InParanoid" id="A0A167KH79"/>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Phosphoserine intermediate" evidence="8">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD68095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="496" mass="55158" checksum="A3DB23077B5FB300" modified="2016-07-06" version="1">MLVAKNEPAPQNVIMMISDGFGPASEAYARQYHSWDQGLGYKAMLPLDTILVGSSRTQSSSSMITDSAAGATAFACAQKSYNGAIGVDSKGVPCGTVLESAKLHRNMLTGLVVTSRITHATPASFSAHVLGRDSENDIASQQIGFNPLGRTVDLMFGGGACEFTSNLTEHSCRLDTRDLFEEAKESFGWTVKRTREDFDEIEPSDAELPLMGLFAPDHMSYEIDRDSSKQPSLKEMAKKALEILNVASKKQGTGFFMMIEGSRIDMAAHTNDPAAHVHEIYEYNQAILAVKEFVDANPNTVVISTSDHETGGFTIGRQIGKDYPEYKWNPEVIKRVQHSSQYLAGIWRKEIDASDEDYSAKVKEFLVTVILRDGLGIDNPTDEELERLMSWKGSNKWTEELAYDLTDMVSRRALLGWSTHGHTAVDVNLYAYGHQSEKLRGNHENTDIGDFIVEQLDLNLEDITERLKSHDSFKEFGVNNIENSNTTTNKHKYHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L3L3</accession>
    <name>A0A167L3L3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_66258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287557.1">
        <property type="nucleotide sequence ID" value="XM_018441616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L3L3"/>
    <dbReference type="GeneID" id="29002522"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_66258"/>
    <dbReference type="InParanoid" id="A0A167L3L3"/>
    <dbReference type="OrthoDB" id="2223205at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="43919" checksum="CAF56012A2CC5EB4" modified="2016-07-06" version="1">METSSTTHYILITNGESYTGHALTWYLANQLERQPGRLHKKNWKVRVLCESLKNMKKLEGMGIDIKEVDYSSQFALRDHMKNVKCALFVPNMSDHCVQYGINVLDAAAEEKLKCIQMISMCSSEQASYENTVLGQFRQLEDHLSKKFAYGRWFPLLYQLAFFWSGMIQDKGKLGLPLSDNTSFPAIDVLDLCDACATLLLSPRKQTESDNQDDEPDIPDQALKRIYHLSSSHNYTGKMMTESLNKGLENEEACVEYEKISNKDMRDYLQNLSTTSAIKDMVSSITENIPKIPYNMRSSSGTSNSDKEHDQPTSCGMDLPALLPNPGHYLNSYVIDLMMDLFENIENYPQEHPTHDLQGLIGRDPKRFSTFFADNRKHFTPSSKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LBT1</accession>
    <name>A0A167LBT1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_71524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288125.1">
        <property type="nucleotide sequence ID" value="XM_018442493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LBT1"/>
    <dbReference type="GeneID" id="29003399"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71524"/>
    <dbReference type="InParanoid" id="A0A167LBT1"/>
    <dbReference type="OrthoDB" id="10044727at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="63089" checksum="2EB5C427ABF21199" modified="2016-07-06" version="1">MDLPLSHCLKHRPYTQLIIFFQKHYPSFSTRILNATNSLSHTLVENTISETSQEELFDAETESENEKIQLSYENLCEYIKQQISFPSDRCISVYEIMKHQAVKTYFFNRIQDFRKMEALIQAMENVYNQTNTYLSLAIRKWGKEYIVTRYISRRQQGKFIRPPFILADEAIANATSNWICQQKIEKRTASNVKRYIDQILYPVKFGVVGDISLFSINKYMKTWGFSFRKSTSTVYVNGHKREDVVKRMEEYSGDNKEVVEEPKVLHRRDGYWTSDNIIKQLTKDVISLFELLHPDSQAVFIFDQSSNHQAFANNVLLAKRFTLNNKPVKEDKEFDFKNTTFLLDGEPCPQAMYYMKMETITKKKRSVDIAVKYVKEIRNEEPDSKCCAHHFLAVQPNFKKQKIIICEVVKANDHIFEMYPKFHCECNWIERYCGPAKDLVRKKSDYNFKSLKINVNSYLDRAVIFILKLTSARKKIPDRDLTYLSELTSWIEILKSGIQLVIPFNICPQCYTDWFPFLLIKTYYIAFHKCKTNMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LCM5</accession>
    <name>A0A167LCM5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_60048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288188.1">
        <property type="nucleotide sequence ID" value="XM_018440593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LCM5"/>
    <dbReference type="FunCoup" id="A0A167LCM5">
        <property type="interactions" value="559"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167LCM5"/>
    <dbReference type="GeneID" id="29001499"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_60048"/>
    <dbReference type="InParanoid" id="A0A167LCM5"/>
    <dbReference type="OrthoDB" id="10252687at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF0">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="128"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD70148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="327" mass="37500" checksum="9BC0806F6FF496C8" modified="2016-07-06" version="1">MCKRLDAPWDDMTASHIRAALYFDQGAYLEAFDAQKEVVQSFQRSMPSLTRWCLPILYVINNDLRNIALKADEDSTLTGQRKKLEEAANIINLQKSQLKQRNLCKNILRALKAAEMPPLQSFPKSDRVTFRFYLGKLYFLEEDYPKARLASRDAENELSLAFRECTKASQRNKELILEILLPIRLMHGVVPKPEALARFPRLEQLYGPLTAAMKRGNVREFDECLVTSEQELIRQGTYLAVEKAQSIAMRQLFRKVFIILDSNTRIPIALFKKALDFVGMDVGVEECEWMLATMIYKGYIKGYLSHEKSFLVLSKADPFPAINSSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LD21</accession>
    <name>A0A167LD21_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">nicotinamidase</fullName>
            <ecNumber evidence="6">3.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nicotinamide deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_115596</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.19" evidence="6"/>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288219.1">
        <property type="nucleotide sequence ID" value="XM_018428471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LD21"/>
    <dbReference type="FunCoup" id="A0A167LD21">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167LD21"/>
    <dbReference type="GeneID" id="28989377"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_115596"/>
    <dbReference type="InParanoid" id="A0A167LD21"/>
    <dbReference type="OrthoDB" id="1739143at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019363">
        <property type="term" value="P:pyridine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01011">
        <property type="entry name" value="nicotinamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008623">
        <property type="entry name" value="PRK11609.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD70179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="209" mass="23266" checksum="5B9376CC124632E9" modified="2016-07-06" version="1" fragment="single">LVLVDVQYDFLETGTLPVPKSSEIIPVITKLMKLIKDNGGLIVATQDWHPDNHVSFASNHKDKLPFQSTIIYHQGIPVNQVLWPVHCVQNTHGAHIVDAIPSELIDYTVQKGLNHNVDSYSGFADNQYFEITKLAKILYQNHIETVIIVGLAADYCVKMTCLDAIKFGFKTILIKEATRSVNPDEFDSTMELLNSKGVIIAHAKDLAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LSX2</accession>
    <name>A0A167LSX2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_148243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD71027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289067.1">
        <property type="nucleotide sequence ID" value="XM_018432043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LSX2"/>
    <dbReference type="GeneID" id="28992949"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148243"/>
    <dbReference type="InParanoid" id="A0A167LSX2"/>
    <dbReference type="OrthoDB" id="2288096at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="758" mass="85930" checksum="848EEF2D273A12AA" modified="2016-07-06" version="1">MNLDCLQRHPSKLFLTDGLFIRKGVKSEPLNDLAEGTELRQIASVLSMNNRVAFPFTNNIFYTMNIKKTGNPMCVRVLSLCKDDADIAFAKTMQTSVTVGVRLQSFRKFSARPSLTTNLPATPQYSQSYNVTFQIKCGSLCLLFTYCIYSTRVLHHQLILRDQIELFHAAKKVPICDPVESECRLTPGNLAKSTLPKKRPKISIPDDAQWCMDNSRLLTFRKFLEKFDCLDQRESEQRYNNILTKYVHNKCKERAKIEYNTWTKSADYKVFWNDRAELDIILQTNKQSTGFIGLVTGQRMKSLMDKANAVAQTTTSNTSTQEIAKDVTDDSEKTNNDAIPDSNTINDTTDDIDSHNNADGISSFDLKSCIDSSSEVCKDPWIFRGNNITRMFKDYQSIVQSLVRKHVALPLETYINELAALTHILVLNKNQHSSIAKKVFSVDLLDYLAVSLVSESMDYNLSMNDQQYMAMAKIINQLSLSNTTREKAFLELTLMSSRMNYSERRLIHGITNLIQKLPNLPLKDNSSISESELWSTYFDPLLSCLICDPEKLVHLRWTNAIPSEGGKLRPDAIISKRQQLEYEGSIGHGEVKINQGSSSRYLLCMDTLRLAIFNKNAIDVNKLDGALAFQIHVANLRFPESFEDLPSFISLKNITLLLAVNDVFWRLCKKSDDTATITSRYKETVNLEGLTGTSQDPVKVDLDVLALILSPVRDTRGVWMEFQRADFNKRIKTAKANVHEHIVQQTVASMKLTASEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LYZ9</accession>
    <name>A0A167LYZ9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cryptic loci regulator 2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_78387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289419.1">
        <property type="nucleotide sequence ID" value="XM_018443361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LYZ9"/>
    <dbReference type="GeneID" id="29004266"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_78387"/>
    <dbReference type="InParanoid" id="A0A167LYZ9"/>
    <dbReference type="OrthoDB" id="2274007at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070824">
        <property type="term" value="C:SHREC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038986">
        <property type="entry name" value="Clr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031915">
        <property type="entry name" value="Clr2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046:SF1">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16761">
        <property type="entry name" value="Clr2_transil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cryptic loci regulator 2 N-terminal" evidence="2">
        <location>
            <begin position="65"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD71379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="362" mass="40867" checksum="1B6175162C1D3BE1" modified="2016-07-06" version="1">MRFKSKASRFPSDGIRSSTPFKRNLQPILKEKSEYKDIIKAIEHQLNNYRDYNGILDFDQNTFRVSELPDGYQFMAKSTRTQTLKSSFNHIRGHPTGKNYSTTNEFAPHLYWLRTQHMTGEPCYCHLCTGPRGVATYTSDQLVKPVPNFVNQEDSDSEGRLSISLEDITSYVPFVKIKIKRYLDISEATLPISNIDTNKSNAQNEATKKPQEEPSPRKKRGRKSARIGEGSQGENSTSNSDANANTKPIAKPIAKPMAKAKTKAKLKHKYNDGKSGSEYEGNDYYVRENKKKNKDENETGNREGDEDSDSEQMSINLVPIRRVVGFKIKFWTGVKVESIPIIPIPELVLIGDAIGNLPAIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M059</accession>
    <name>A0A167M059_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_159270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289486.1">
        <property type="nucleotide sequence ID" value="XM_018433956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M059"/>
    <dbReference type="GeneID" id="28994862"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159270"/>
    <dbReference type="InParanoid" id="A0A167M059"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007890100" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="11027" checksum="729A3C285AAEFE9E" modified="2016-07-06" version="1">MFLLSVLIFLVISQFIPTIRRPISIQGYRHTSLLHHLLTACFICPESSQLMSTVTVLTYISNHSCIFPYFLRQRPAIKVSLSIKILSYLDIVKTND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M980</accession>
    <name>A0A167M980_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_170074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290217.1">
        <property type="nucleotide sequence ID" value="XM_018436244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M980"/>
    <dbReference type="GeneID" id="28997150"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170074"/>
    <dbReference type="InParanoid" id="A0A167M980"/>
    <dbReference type="OrthoDB" id="8951911at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1" id="KW-0563">Paired box</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Paired" evidence="3">
        <location>
            <begin position="27"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD72177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="253" mass="28883" checksum="05AE601829106913" modified="2016-07-06" version="1">MSDTERTPVLHTKSRKGMKYSDATHSTHIRHLIIEKSKNQLKAPSEIAKELNILHSTMNTIIGRFERTGSVEYKSLGGDFRTIIKDHHKQFILDMIDSNNTITLAELQQELGRGLNPGKELERKKAEPKGIKLWLVFPMTTKDMRVGFDVGRETKDLINLKMISFPPSPFSPVKGAYHIIARNESVADIQHIESNRRIMWNTHGEVQPGGSIYSTQINPNMFMHSKQQHKMLASIFTMYKQSVSDSDNVNNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MIB1</accession>
    <name>A0A167MIB1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_65156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290956.1">
        <property type="nucleotide sequence ID" value="XM_018441406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MIB1"/>
    <dbReference type="GeneID" id="29002312"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65156"/>
    <dbReference type="InParanoid" id="A0A167MIB1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="137" mass="15664" checksum="FAA3C394E2BFDB90" modified="2016-07-06" version="1">MFTRSGRSLSMRSLHIDFMRQTVASMLFCKSYLYCGTKKWIVVGFWLQIDWLYCNIEYIDYIEYIGYIGYTLVVLANYNYNRTDQNQAMITMGINTGIKGGILDPFLDQKGSMIMIMIMSMSMSVSVGVGVVIITGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MUU1</accession>
    <name>A0A167MUU1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_168471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD74064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292104.1">
        <property type="nucleotide sequence ID" value="XM_018435876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MUU1"/>
    <dbReference type="GeneID" id="28996782"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168471"/>
    <dbReference type="InParanoid" id="A0A167MUU1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="173" mass="20123" checksum="2A8A96D28008CD06" modified="2016-07-06" version="1">MLKLLFNKHSAFSIIENMLLLYPIATEDPKQQAFNKPNAKTPYHIENTFGLLVQKCCFLLRHLYFLETFPKTLHDFENKIQNFDAYSDGNDDNDVKIEVEDLDLFINKIPVNLENASLTANCSVRQIQSAHDLSQERGRQRRERMTERKSQLAIITLQKLLGLPYVKEGRILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N2Q8</accession>
    <name>A0A167N2Q8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_61127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292864.1">
        <property type="nucleotide sequence ID" value="XM_018440754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N2Q8"/>
    <dbReference type="STRING" id="763407.A0A167N2Q8"/>
    <dbReference type="GeneID" id="29001660"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61127"/>
    <dbReference type="InParanoid" id="A0A167N2Q8"/>
    <dbReference type="OrthoDB" id="2285313at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD74824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="45798" checksum="AD5DAC75763F4AB2" modified="2016-07-06" version="1">MLPSSYPAPMGERKLYNISKYLSAPEIFFGGPSSESLYWLLHMDRLKKDAGMTNKEAILVVATHFYGMAAKWWAICEAKVTTWEVFSEEFKKQFASRQIEDVRWTEIDKTRQGAGQSIGEVTIHLQELFGLVALANEAQKIQILLETLHPEIAYEVEKSGLSRSWDELVHLALAVLVLALAVLVLASVVLVLVVLVILVVLMGSLVLVFVGLVFVVLVLCLVFVVLVLCLVWLALLVLKLIVVSMFEQEQRFRKRPRASVSFADAHNQPKVSVSEDTAVNMVETAPVYAAKHARVVDPSLSKGLYTHVIFLEKKEKQSADEKYGKAVNKTVLLHTLSNTLPPLQQHLYAQGQLNTFPTNDTYMTLAPDLSPPVSSFPLAPKPHRLRPSPRELPVHISHNTAKGGPIQYTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N682</accession>
    <name>A0A167N682_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Repressor of RNA polymerase III transcription MAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_111544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293150.1">
        <property type="nucleotide sequence ID" value="XM_018428219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N682"/>
    <dbReference type="FunCoup" id="A0A167N682">
        <property type="interactions" value="542"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167N682"/>
    <dbReference type="GeneID" id="28989125"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_111544"/>
    <dbReference type="InParanoid" id="A0A167N682"/>
    <dbReference type="OrthoDB" id="277029at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037240">
        <property type="entry name" value="RNA_polIII_Trep_MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="23003" checksum="A78722AE723A99A5" modified="2016-07-06" version="1">MKFLEVDSLDVLNTVFRWETVEAILTGRIEAYSCKSAGSDKKLFKQIENKYSVDLSGGSISPDDYLHTIVSPFGRLDESTPRKTFFYLLATLNAAFPEHDFGDVRPDQFSKQPSPEMVINSVNTTLFNLGNDEIVNKYRMWDTLDEIVDLSECDVYSYNPDIEDDPMNDEEGYLWSINYFFFNRKLKRMVFFSIKSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N6G3</accession>
    <name>A0A167N6G3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_167450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293170.1">
        <property type="nucleotide sequence ID" value="XM_018435642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N6G3"/>
    <dbReference type="STRING" id="763407.A0A167N6G3"/>
    <dbReference type="GeneID" id="28996548"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167450"/>
    <dbReference type="InParanoid" id="A0A167N6G3"/>
    <dbReference type="OrthoDB" id="2262293at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="248" mass="27867" checksum="127DA08BAB7A9A52" modified="2016-07-06" version="1">MKKFYFLVFEKNMSIRGAAKELKIPPCTAQTWYTKDQKSIESGEDLYLRKPGNERPVGRPLTINSEQKKYLINLIDQKPGIVLDEMMDGLTSQFTNLDISRSSLYKYVAAHCGMSVKRALFRPAERNSDTKIEARFQWVTELLKTDIDYITDCVFINESGFNIDMKRSMAWAPVGETPIVEIPKTRATSHTTIGAISPLGVINVQLKVSKVVVASNSKKRKGPGGAIKKPEKEKGKENPLGCDIFKDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N7K4</accession>
    <name>A0A167N7K4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_71997</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293279.1">
        <property type="nucleotide sequence ID" value="XM_018442577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N7K4"/>
    <dbReference type="FunCoup" id="A0A167N7K4">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167N7K4"/>
    <dbReference type="GeneID" id="29003483"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71997"/>
    <dbReference type="InParanoid" id="A0A167N7K4"/>
    <dbReference type="OrthoDB" id="5817083at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46283">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="10">
        <location>
            <begin position="86"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD75239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="430" mass="48367" checksum="F5798AC03B550443" modified="2016-07-06" version="1">MSHFKSSSPLPTEPSRQYTANFPGSTSNSVNKKSSFSSVGPRSPSSSSTPSTLNTEQQKSETSDKVQTSISSRSAITTPDQPTYSETEYNERRCWICFGEDGDSEGRWVSPCQCSLIAHEKCLLRWMFESQKKEPLKQVTCPQCAFPYSFQQKTSLSYIMITLGERALSTIAPYFFGFTIGCSIIIAATTLGAFTVVTVMGPKDSERLIGNPAQWTWRAWVGLPLIPATLLTSIFPFANVYPFVAFTFMSMASRSYRRPSLNWPPSVFDVVIGYPMVRMVYVSARNATYRLVVRRSMLRSSSPRQSLGLNASSSTPQLSNIEQNNENSYSDIQPINDIQIDEIETRRMPDILLSSMCALLLPFTGSALGNLLTYFKPVKRYFPAPFHRTILGGCILVVSADIIDMWYAHSVIRQHQSRRIRNYSEIKQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NIE4</accession>
    <name>A0A167NIE4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_59518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294028.1">
        <property type="nucleotide sequence ID" value="XM_018440514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NIE4"/>
    <dbReference type="STRING" id="763407.A0A167NIE4"/>
    <dbReference type="GeneID" id="29001420"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_59518"/>
    <dbReference type="InParanoid" id="A0A167NIE4"/>
    <dbReference type="OrthoDB" id="3039677at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="200" mass="23015" checksum="B6FBC094F6AB800D" modified="2016-07-06" version="1">MMIHISTIDDIVSLLKMIYHKNCDVIGSIIYIFINNLPRNERYKPENTLLVGLMPGLKEPKSKEINHYLQPMVDDLIRLYEGLAIPTFECPSGVHIRATLMMVACDILAARKTSGFTSHNSTCACYKCNRHFPCLENGVNVDFCGFDFSRWVLRDGIENRLHAEEWESASNPSERHWLEVKNGVRWSVVIQTLGCWIYHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NND4</accession>
    <name>A0A167NND4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_166307</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294374.1">
        <property type="nucleotide sequence ID" value="XM_018435398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NND4"/>
    <dbReference type="GeneID" id="28996304"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166307"/>
    <dbReference type="InParanoid" id="A0A167NND4"/>
    <dbReference type="OrthoDB" id="2273044at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD76334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="540" mass="61878" checksum="229833C3CCAF469B" modified="2016-07-06" version="1">MNKPQERPSNTGILPVADERNYDVDMGKCLNASSAVRQLGIHIRAAQRWVKRYYEDSESIFENKRKNQGDVVFLGMSISAISATGLINVSLRVPERIKKRKLRCETDVISKASFLILLNALISVLTKKDYKNGHSNLNVKKYTKEGTEIIIKFSCPGCRDVFSIVSELAHHVDNNHVKRAPTLENLTIEDQRWVLNGHDISSQFQEYRQSCITASRTTEFAVESHFNELLAISGIPVLQRRGNYEDLPTDIFPPSSLTTVRTEILAEYKRNTFQLHIREAVQSIIQQFVDENITEIRAKIELLSLCEPVVTPSPQDSIEPTEYECAVIMAIVALLSYLYDCDIYAHLFMHDLLSAKKPSKVAHCSNIVPEEFDDAVNRPDYKIDVYAYSGYRFSYTNAYGDVKKSRNVSVTLLAKDFYRLCIFSKEAIDRYNLINVLSFQVTANSVTFFAMQLKSPFLYTVTELVRFCILAKKCDLLDLMGKMDNLLFVASLYRDHCVVSENNLTPWRCDTLSSAKWQDLYLRPRNKLRVRNSCYLKVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NPQ3</accession>
    <name>A0A167NPQ3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_158308</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294448.1">
        <property type="nucleotide sequence ID" value="XM_018433763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NPQ3"/>
    <dbReference type="FunCoup" id="A0A167NPQ3">
        <property type="interactions" value="499"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167NPQ3"/>
    <dbReference type="GeneID" id="28994669"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_158308"/>
    <dbReference type="InParanoid" id="A0A167NPQ3"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000006">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057254">
        <property type="entry name" value="UCH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00140">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="13"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD76408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="239" mass="27075" checksum="995EC9186E88C9F5" modified="2016-07-06" version="1">MQEEQTHKPTEQKWLPLEANPDVWNKIIHRLKVNSQWNFVDVYGFEPELLAMIPRPVTAIIFLFPLTENYEKFKEEEEAHLARHEQNISPDLIFFKQTIANACGMIAILHAIANNDNEIVGPGLLSNLLEKAAPMSPDERAELLENCTELSSVHQEAANQGQTQTPDLGDEVNLHFSCFVKVDDHLYELDGRKPFPINHGKCTDLVASAAKIIQQHMARDPDETEFSAIALTKQPQSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NQK5</accession>
    <name>A0A167NQK5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_166426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294499.1">
        <property type="nucleotide sequence ID" value="XM_018435415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NQK5"/>
    <dbReference type="GeneID" id="28996321"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166426"/>
    <dbReference type="InParanoid" id="A0A167NQK5"/>
    <dbReference type="OrthoDB" id="2284908at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="210" mass="24118" checksum="7AC92E3709B25B6C" modified="2016-07-06" version="1">MTMKNSIPTKDEGERNLPLILMPWVILQSHIYWCCSALYYICHPPNRSPPTRRNSIQLSTPHFSKSHGRARAFSDPTYQQAAPVFSVHDTSKDKPKQNNRFMSTFQRRPYRTSDDLFRPTMQQEREGTTLPPVWIQKARHLMGSSPANLSEPTKSNLSGPTASSNDSKRGPILLRKLNKKNKDQNLVKSKDTKKKKYLGLLKQTTIHPFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NR12</accession>
    <name>A0A167NR12_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_63300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294534.1">
        <property type="nucleotide sequence ID" value="XM_018441101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NR12"/>
    <dbReference type="STRING" id="763407.A0A167NR12"/>
    <dbReference type="GeneID" id="29002007"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63300"/>
    <dbReference type="InParanoid" id="A0A167NR12"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="184" mass="21217" checksum="B5DA343214C549BC" modified="2016-07-06" version="1" fragment="single">MLPLNSTILVKASEWEKCLEQINVLCSTKWNKKHKYSGKGLVFGETKKCHRAGQYITNRQLRFAQKDMKACSCTAALKIIQHLDNPNVVAFCQTRAHVNHVPRDWDEVRTLSLPSEVIKIIEDQLKSGSSCRITRISVLRQIDSWGVGVRKPNYEEIYNRMRKMTTLLYMFASDENASISIWLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P1P2</accession>
    <name>A0A167P1P2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Secretory carrier membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_101372</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295116.1">
        <property type="nucleotide sequence ID" value="XM_018427637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P1P2"/>
    <dbReference type="GeneID" id="28988543"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_101372"/>
    <dbReference type="InParanoid" id="A0A167P1P2"/>
    <dbReference type="OrthoDB" id="242866at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007273">
        <property type="entry name" value="SCAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687:SF90">
        <property type="entry name" value="SECRETORY CARRIER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687">
        <property type="entry name" value="SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04144">
        <property type="entry name" value="SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD77076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="22592" checksum="18145111CD633CC1" modified="2016-07-06" version="1" fragment="single">GTNNFPPCFPLMYLDIPAEIPPEHQWTVWWIYREWLLFELTLVLNFIACLCVLFSHPASVTSGPTDLGISLTEMFTHTLASFFLWYRPAYNAYMKDVSLYYFSFFIFNGFHILYTFYKAVGIPSTGGAGLILLVSLFSDGFIVTGIFTLLATICWLVMGFGAIYLYKRTYDHYKSTGHTFSEAKQEAFVRMGRSAYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P7Q2</accession>
    <name>A0A167P7Q2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_76368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295456.1">
        <property type="nucleotide sequence ID" value="XM_018443147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P7Q2"/>
    <dbReference type="GeneID" id="29004053"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_76368"/>
    <dbReference type="InParanoid" id="A0A167P7Q2"/>
    <dbReference type="OrthoDB" id="2281119at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="122" mass="14443" checksum="CE5D51295047C79B" modified="2016-07-06" version="1">MLIKVQYAVNGTIFGRLNEYCLMIRKQYPMLPVSIGFCINSTNQEFKDLTYECERPFNQQPLHPLNALGRFFKYRNRKKEMQLLDCSTELLDVYSEMKQLMKNESKEQLTLFAASRHHISPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PE30</accession>
    <name>A0A167PE30_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_141602</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295779.1">
        <property type="nucleotide sequence ID" value="XM_018430627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PE30"/>
    <dbReference type="STRING" id="763407.A0A167PE30"/>
    <dbReference type="GeneID" id="28991533"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141602"/>
    <dbReference type="InParanoid" id="A0A167PE30"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD77739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="214" mass="23572" checksum="E5C181EC93368397" modified="2016-07-06" version="1">MTSEPTHRSTCDFFETNNYFGLDKSNFLYFQQGAIPCFTLKGILMFEQKDKMAITPDGNGGLYDALYKQEFSEISEFSAHQSTDTTSSSSSSIGDEVSSLVFGSSNIVSHLFSTGFLESASIFADQLEYHTFSALHVNRSSEFSLVKNGPARQDMFKLHAKHVEQAGRVVAPQVKIELSPLVSYFGEGLAIFEGKIMAKSGIIHALVDISTFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PWI9</accession>
    <name>A0A167PWI9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_154425</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296704.1">
        <property type="nucleotide sequence ID" value="XM_018433325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PWI9"/>
    <dbReference type="STRING" id="763407.A0A167PWI9"/>
    <dbReference type="GeneID" id="28994231"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_154425"/>
    <dbReference type="InParanoid" id="A0A167PWI9"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04153">
        <property type="entry name" value="Arl5_Arl8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000728">
        <property type="entry name" value="ADP-ribosylation factor-like protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD78664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="179" mass="19969" checksum="6EC1402330CDE524" modified="2016-07-06" version="1">MGIVFSGLWNRLFSKTEVKIIIVGLDNAGKTTILYKLLMNQVVTTTPTIGSNVEEVEYKNIKFLMWDIGGQESLRASWKTYYINTKAVIMVIDSTDANRLPVAKHELHQMMESEQLQNASLLVFANKQDVKGALSASQISEALGLTHLKDRQWHIQACSALSGDGLFEGLDWVVLQIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PY01</accession>
    <name>A0A167PY01_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">60S ribosomal protein L44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_179681</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296788.1">
        <property type="nucleotide sequence ID" value="XM_018438192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PY01"/>
    <dbReference type="FunCoup" id="A0A167PY01">
        <property type="interactions" value="448"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167PY01"/>
    <dbReference type="GeneID" id="28999098"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179681"/>
    <dbReference type="InParanoid" id="A0A167PY01"/>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007891345" description="60S ribosomal protein L44" evidence="5">
        <location>
            <begin position="19"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD78748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="14016" checksum="CB4D49FD37CA38C8" modified="2016-07-06" version="1">MLISIAIIVLTCFALSSTTFVNIPKTRNTFCKGGKCKKHTPHKVTQYKAGKASLFAQGKRRYDRKQSGYGGQTKPVFHKKAKTTKKIVLRLECTACKYKMQLSIKRCKHFELGGDKKTKGAALVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q8K5</accession>
    <name>A0A167Q8K5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Endocytosis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHYBLDRAFT_179053</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the END3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297314.1">
        <property type="nucleotide sequence ID" value="XM_018438093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q8K5"/>
    <dbReference type="FunCoup" id="A0A167Q8K5">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167Q8K5"/>
    <dbReference type="GeneID" id="28998999"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179053"/>
    <dbReference type="InParanoid" id="A0A167Q8K5"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025604">
        <property type="entry name" value="End3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12761">
        <property type="entry name" value="End3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EH" evidence="16">
        <location>
            <begin position="8"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="16">
        <location>
            <begin position="155"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAD79274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="428" mass="47760" checksum="254945799850E86B" modified="2016-07-06" version="1">MSVITSDEKTKYAEIFQARGAVNGYMSGSIARDVLLSSSLPPDRLERIWDLSDIDKDGSLDFEEFCIAMHLTFECINGAETPTSLPPSLVPQSKIHLFPNGYMSQPHSGMMPQQTGMMPQQTGYAPYQQPYATGYTQASPASGPVEFSWDMTPQDMTSYQNIYSKYANETGKVKFGLMDDFYRSLGLSHADLSDAWSLVDVNHTLALTQDQCITYFHILNQRTKGAPIPKELPPDLQAAFAGEYAADLGERPGAGTGARKGNNQSMSKSAQLADSYVNRLGVASTSLSSKGVCVCVCVQMIGTSVKGEKYDEEEMLKRELAALKLQAKEAEKRALAMKENNSAHDFESRPLRDQFQALYDYKLQQLTNQADVADKIQKQSRDIEVGRDAIRRLDRLVEEARDKKRELEALLEERRMEVVKTDRLLNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QFE5</accession>
    <name>A0A167QFE5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Heat shock protein 70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_157282</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297658.1">
        <property type="nucleotide sequence ID" value="XM_018433590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QFE5"/>
    <dbReference type="FunCoup" id="A0A167QFE5">
        <property type="interactions" value="578"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QFE5"/>
    <dbReference type="GeneID" id="28994496"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157282"/>
    <dbReference type="InParanoid" id="A0A167QFE5"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140453">
        <property type="term" value="C:protein aggregate center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000134">
        <property type="entry name" value="Heat shock cognate 71 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000021">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="608"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="614"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD79618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="649" mass="70506" checksum="563833352CD78B34" modified="2016-07-06" version="1">MPKAVGIDLGTTYSCVGVWQNDRVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPYNTVFDAKRLIGRRFTDSEVQSDMKHFSYKIINKDDKPAIQVEFKGETKIFTPEEISSMVLIKMRETAEGYLGTKVDSAVITVPAYFNDSQRQATKDSGAIAGLNVLRIINEPTAAAIAYGLDKQTKGEHNVLIFDLGGGTFDVSLLTIEDGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFKRKYKKDISENARAVRRLRTACERAKRTLSSSAQTTIEIDSLFEGVDFYTSLTRARFEELNQDLFRTTMEPVEKVLRDAKIDKGSVNEIVLVGGSTRIPKIQKMVSDFFNGKEPCKSINPDEAVAYGAAVQAAILTGDTSEKTDSLLLLDVAPLSLGIETAGGVMTPLIKRNTTVPTKKSEIFSTYADNQPGVLIQVYEGERARTKDNNLLGKFELTGIPPAPRGVPQVEVTFDVDANGILNVTALDKTTGKSNKITITNDKGRLTKEDIERMVNDAEKYKAEDEAAAARIAARNGLESYAYNLRNTLAEEKVSSKLEPADKETLTKAIDEAISWMDNSAEASKEEYESRQKELEEVANPIMTKLYASTGGAPGGGMPGGAPGGFPGGAPGGGAPGADGPTVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QS55</accession>
    <name>A0A167QS55_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_35571</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298218.1">
        <property type="nucleotide sequence ID" value="XM_018440057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QS55"/>
    <dbReference type="FunCoup" id="A0A167QS55">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QS55"/>
    <dbReference type="GeneID" id="29000963"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_35571"/>
    <dbReference type="InParanoid" id="A0A167QS55"/>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="27"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD80178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="165" mass="18559" checksum="FBAC3C9EC61DE5BB" modified="2016-07-06" version="1">MTGPAVRKSKQRNARQNSNAFGIFTGQEIMEYKQVFGIMDTNDDGIVDAKDLEVTFQRLGQPASVEQLENMMSEAPGSINFTVFLTLMADKRADIDQDNVIMDAFSAFDESGKGIINAEYLRECMTTMGDRFTDEEVDIMFKGTPVDEHGNFNYRDFVNVLKHCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R5L6</accession>
    <name>A0A167R5L6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_161531</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298938.1">
        <property type="nucleotide sequence ID" value="XM_018434424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R5L6"/>
    <dbReference type="STRING" id="763407.A0A167R5L6"/>
    <dbReference type="GeneID" id="28995330"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161531"/>
    <dbReference type="InParanoid" id="A0A167R5L6"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF25">
        <property type="entry name" value="F-BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="659"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="735"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="49"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="552"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="552"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="573"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD80898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="783" mass="89068" checksum="D7C9ADDE83E2DA55" modified="2016-07-06" version="1">MSHVDKSFKNWLKKVTLPTRKIVTSTTPNTGRVFSVHLEVSIRYAQSTISYHDTARSDQPQLGAIPIIVARCGAFLKQNALSTVGIFRLSGSSRRIQVLQDIFDKSSTSYGVHIDWHGFTVHDVATLLRRYLNHLPNPVITHEFYQPFCDIMHNRTYTTTNQRIIAFRSLIHKLPLAHQHLLLYLLDMLNVFAQNSCVNRMDASNLAAMFCPAILSHPSQNTPISYVVSQRVIEFLIEFHSLFGMQTISRRKSSRSRQSSSSAFGRIITVSNGKCPSNTVPALRRRRPATLEINLIRTPMYSPESLGDDQFNIGTNIPTRDTKEQEEEEEEERGGLITPRVSGDYDRGNSHVRDDENGQKKTVYKLHDAPVTILPSSTETKPTRPVSLNRETIQLCDAIGSGMSNIDTKLPDPKYKNGLTIDTNLKETSNFEILALTNTNTKIVFDPSDKVLSQSTTSVGTDTVVETSIGSSTDLSLDVLTDEISIEDTDSILEMSLKENLAREEQLMQDEEVMFQWRDLLTRSWKTDESTPKIPLTTSSSVCSKRTDYFGHASLPDDDRSGSHTSTPSRFLEEEEEDDDDDDDDDDDEEEEEEEGNLENKSEMKHTAKQFSCEATWNTDTQQNQPHFQRICQEALLPMNIKGQSNSNRRLIQIRKMRLVLYSWLLYYVLWLCMTLFHNNGCHCAPIIVIIILVSSRLPKPNKIYELKLHVCLCKRRDLPFQPLQFVTVQTQKQVLHFQGLWFMICFLTALGIYGAQAARPCKAIQKGYVSNVYLLIYLSILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R7X9</accession>
    <name>A0A167R7X9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_184536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299099.1">
        <property type="nucleotide sequence ID" value="XM_018438949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R7X9"/>
    <dbReference type="GeneID" id="28999855"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_184536"/>
    <dbReference type="InParanoid" id="A0A167R7X9"/>
    <dbReference type="OrthoDB" id="10255641at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027961">
        <property type="entry name" value="DUF4442"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14539">
        <property type="entry name" value="DUF4442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD81059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="29036" checksum="D5F4BA2D01A253FC" modified="2016-07-06" version="1">MTIMVYKCTYKAIIQGEKSKKEKKRKENFSLKTIHISMGFSLVTDNSLTPLAAAFYSQVQATAQLVRVALELEWTIFSRLIGGVILATTAYIIYLIITLRHTRQPLVMWERLAKPFVKLFRPRLFAFLLGNADPYTRSIDMRISTFSRGFCTGIMRDRHKNRNTLKSIHTTALATFAETVGGLALLSLINNKDRATLTSLKIDYNKRALGLLTASSECVLPAEMEGTHTLTTKVVVKDRTLDTVAVATLVWEIETKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N1X5</accession>
    <name>A0A162N1X5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">UDP-galactose transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_151197</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285718.1">
        <property type="nucleotide sequence ID" value="XM_018432625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N1X5"/>
    <dbReference type="STRING" id="763407.A0A162N1X5"/>
    <dbReference type="GeneID" id="28993531"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151197"/>
    <dbReference type="InParanoid" id="A0A162N1X5"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.20:FF:000037">
        <property type="entry name" value="Nucleotide Sugar TransPorter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD67678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="39115" checksum="9A159A85A22A3592" modified="2016-07-06" version="1">MSAYHTRRTFAKRDLLPTHSNGPEKEDTIFHLSRKQLSLIVLVVQNSTLVLMMRYSRIIQRPDQSMYVASTAVFLAEVLKIIACLAVMYHQQGSWRDFRRMVQEDILAKPRDTLTMLIPSGLYALQNNLLYVALSNLEAATFQVTYQMKILSTALFSVLLLGRSLPRERWFALVLLMVGVTLVQSQSIQSEPSQSDEQSPIVGLLAVLTSCVSSGFAGCYFEKILKTSDTSMWVRNIQLGLSGAFFSLVGMIAYDREVIWAGGMLQGYDWLTWVVVMNQALGGLLVAIVVKYADNILKGFATSLSIIVSGIISFYLFDFQPTIPFVLGATTVMVSSYLYGIDFKTAIKPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N4Z3</accession>
    <name>A0A162N4Z3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ZIP zinc/iron transport family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_153108</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441027">
        <property type="protein sequence ID" value="OAD65854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283894.1">
        <property type="nucleotide sequence ID" value="XM_018433064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N4Z3"/>
    <dbReference type="FunCoup" id="A0A162N4Z3">
        <property type="interactions" value="280"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162N4Z3"/>
    <dbReference type="GeneID" id="28993970"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153108"/>
    <dbReference type="InParanoid" id="A0A162N4Z3"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD65854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="38385" checksum="5584B5EC997B9F18" modified="2016-07-06" version="1">MASLAYAQDVAVDASADADADACASGELENYNLPLRIGSIFIILGTSALGVFGPIALHRINPNSESSARDWILTIGKFFGTGVILATAFVHMLPDAFENFGSDCLSSGWLSYGAFAGIFCMLASFGLQLLELCAISHLNTINKRKVLTARENSAAHFDEISPKNLESDGSMISGTHDGVFQNGGGHVHSAGFLEQDDSYSHIGTFILELGIIMHSVIIGITLATADRDEFVTLLIALVFHQFFEGLALGTRINELKYKSLAKPIIMGCLYILMTPIGISIGVGIHASFNPNSYSNVLSQAILDLLSAGILLYNAYVSLMSLEISHNTKFHEQSLARKTACFLSMYAGAGLMSLIGEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N7N0</accession>
    <name>A0A162N7N0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_80559</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat ESC family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD71878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289918.1">
        <property type="nucleotide sequence ID" value="XM_018443594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N7N0"/>
    <dbReference type="STRING" id="763407.A0A162N7N0"/>
    <dbReference type="GeneID" id="29004499"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_80559"/>
    <dbReference type="InParanoid" id="A0A162N7N0"/>
    <dbReference type="OrthoDB" id="7318948at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051243">
        <property type="entry name" value="PcG_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10253">
        <property type="entry name" value="POLYCOMB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="175"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD71878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="407" mass="46528" checksum="C637498290867027" modified="2016-07-06" version="1">MMGLQKRRLSNTSLSKSKIIKLETNETVPKELSRDERQERVFANMRLRRIVKENHGQISFFFNNKNFAGPVGIDHNKTFDKRGAVQRDQTDTSNILATVGGCQLNVYDNEHCGDHLDIMSNFDLTAGNTEESTVKQNLLTFCWLYREGDAWLATGGSDRKIHIISLANSEEICILEGHTKTIVDIQAHPKNDKHILSTSKDGTMRLWDVDTKKCLVLFEAESTIACFHPSGTKFVSGGSRGELREWQIPNHTVFDGMDDYITVEKRHSRVLKKVHGESYIDCIRYANGNLLSKSINGRIEYWDPESDKMMRSFRVRTGENFSRFDVSLDERFIGVGTSQGSVFIYNIDTGKMVAELAHRRSTKSVRCCAFSLDCRQMVCAGEDGFIWRYDFIEDATLEEWANWKKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N993</accession>
    <name>A0A162N993_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHYBLDRAFT_113755</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290328.1">
        <property type="nucleotide sequence ID" value="XM_018428352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N993"/>
    <dbReference type="STRING" id="763407.A0A162N993"/>
    <dbReference type="GeneID" id="28989258"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_113755"/>
    <dbReference type="InParanoid" id="A0A162N993"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="14">
        <location>
            <begin position="95"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="15">
        <location>
            <begin position="167"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="17">
        <location>
            <begin position="408"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="16">
        <location>
            <begin position="502"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="13">
        <location>
            <begin position="630"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAD72288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="779" mass="85586" checksum="F3F051F9019ECFB1" modified="2016-07-06" version="1">MSLSTVPLRQDTPLFGQPPRIQDLSLPTPTPSLPSNIAATSSTDVQCSSVFNRSTLNFVPATPALLKKSKLPFSLIVEPFPSHVNVPVVTDTIVSRCTRCKTYINPFVKFVNMADWQCNMCGLDNEVPRAFDWDEAQQQHTDRWSRLELNHGCVDFVAPAEYMVRPPQPPVYVFVIDTSFQAVQTGMIGVIADAILASLDKLPNEDGRTKVAFVTADDAVAFYKLIGEEPEVLVVGDLSDIYLPRASSDLVVNLVESRSVVEDLLGRMKTMYQNTHSSTNCLGSALQAARKLLSPTGGKIVCFQASIPTVGDGAVKPTPDQKNSVTDGPLMVPSSAFYRTFATECTKSQVCADMFVIGGHYSDLATLNVIPRFTGGQTHFFPQDKIHSQADKLKLTMEIIAVLSEKVGLEAVMRTRTSPGLVCHAFHGNSTLRPPDIMALPNVPRDQSYCVDLILEEEIKSSVVYFQTALLYTTCFGERRIRVMNLCLPVTRIAAEVFTGADQFAIARSLCHQAIDKAVTSKLKDAREQLSKQTSDICNAYAKEVVGTGSSTAPLSMPLHLALLPLAILSIIKTDAFNDSPLVHIDLRSQSTVLLRILAMDAWVKYIIPRFYALHSMSPVTGSVDPTTGKFIMPTNLNLSSEKLAPHGCYMLENGQQIFLWIGKDAMPSLCVDLLDVPKITSVKSGQITSLPTLKSALSQQVNAIIKYLRTEGRKNTYYPSLYVVREDDDPVLRSLFLSHLVEDRQPNGPALAGSNQPMVSSGMSYFQWLGHVRSKCQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NEA8</accession>
    <name>A0A162NEA8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_145908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291558.1">
        <property type="nucleotide sequence ID" value="XM_018431558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NEA8"/>
    <dbReference type="GeneID" id="28992464"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145908"/>
    <dbReference type="InParanoid" id="A0A162NEA8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="338" mass="37933" checksum="1A1DF997371CA7F4" modified="2016-07-06" version="1">MIATSPCVRTQMMHTHACPDIRSYFEMAKPKFICVKGYASRTDQLGISDFSPSHPHSRRSLIDMVWFIYQTKQGELEIVTKKGRLQLATGNAYSQETKTRVEGHLRTLSVVKEKQGYFRRTYPIQGRPVTGLAIIQPFREYQRELVSVGLYQKGSWCGKPRSGSSSAIRWSNPFVVDPIAASWHIVSTGSLVVYCGWFRIPPAGGQGPFRPVIEEHFAVPSPSLQMMIHIPRSIPLLTKQILSIKSYSALSTPIMWKIPKPESCASMTASRTNRGAFLYKSKIWVVSPSLKAKSISKKGSNAKFQKQVPKEKPKTKSEAYTKSSSPKGSKEIQTRGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NEJ9</accession>
    <name>A0A162NEJ9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_133421</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291628.1">
        <property type="nucleotide sequence ID" value="XM_018429570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NEJ9"/>
    <dbReference type="FunCoup" id="A0A162NEJ9">
        <property type="interactions" value="612"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NEJ9"/>
    <dbReference type="GeneID" id="28990476"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_133421"/>
    <dbReference type="InParanoid" id="A0A162NEJ9"/>
    <dbReference type="OrthoDB" id="429671at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD73588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="297" mass="33519" checksum="F3A6FD790F8FC407" modified="2016-07-06" version="1">MKRWKFSSRSLNTEINIYIYICVCVCVSFTVFQGRQEDAEEFLCFLLDGLHEEMVAVLKDQNDKRSQEAAANGTQDVWLEVGPKNKTSSLRSPGFQESPISKIFGGKIRSVLRCPGAKDSVNLEPYQSLPLDIQPSNVNTIQDAIRNMTLPETMHDYMSPKGVCVDATKQIYLENIPPVLILHMKRFVFDNVGGVQKLQKQVTYGTTLTIEPEWMAQGSKSSGPVSYQLFGVVYHHGVSAGGGHYTCDIKRRNGEWLHIDDTTITPISEQQVLVTENTRTESIHTDQTAYILFYMRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NG91</accession>
    <name>A0A162NG91_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_172535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287324.1">
        <property type="nucleotide sequence ID" value="XM_018436825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NG91"/>
    <dbReference type="GeneID" id="28997731"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172535"/>
    <dbReference type="InParanoid" id="A0A162NG91"/>
    <dbReference type="OrthoDB" id="2355444at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="222" mass="25804" checksum="E99653BF0E8EED6F" modified="2016-07-06" version="1">MTPTPDNTSREVTKAYAYYIPKGYFYLAAETWANFRVEQTQNFSRTEIYENDLDVMLAANESKGLSFLLSNNTTNCPYHKPPNSTNSPNRRVIQFILGPGEEKLLIHQTVTSPLTFAFIRLIQCCKMYENKQESRLYLQRPVLLLEEMDRVVFKDTLAPKVDHVREKLYKILFGNMSIAKGVLPFWNTICDWARYLQSDNPEHCLILGLQTYKLAKQYCAHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PL06</accession>
    <name>A0A162PL06_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_92954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287936.1">
        <property type="nucleotide sequence ID" value="XM_018443811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PL06"/>
    <dbReference type="STRING" id="763407.A0A162PL06"/>
    <dbReference type="GeneID" id="29004716"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_92954"/>
    <dbReference type="InParanoid" id="A0A162PL06"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD69896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="119" mass="13457" checksum="E186FD4974A4081F" modified="2016-07-06" version="1" fragment="single">LTSLTLQNNRLSELPDELWRLIGLRELNLGCNRLKRLPVEIGLLVNLEELYVHSNQLSAIPAQLGSLVRLRILDLTGNYLMYLPVEVKAMSLSQLWADQNPFGPLNPDRLSKVLSLRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PLH5</accession>
    <name>A0A162PLH5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_156103</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD70036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288076.1">
        <property type="nucleotide sequence ID" value="XM_018433464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PLH5"/>
    <dbReference type="STRING" id="763407.A0A162PLH5"/>
    <dbReference type="GeneID" id="28994370"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_156103"/>
    <dbReference type="InParanoid" id="A0A162PLH5"/>
    <dbReference type="OrthoDB" id="2243669at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07751">
        <property type="entry name" value="PolyPPase_VTC4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF2">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 3 COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="626"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="664"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="7">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD70036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="692" mass="80189" checksum="A48D777C13BD14AE" modified="2016-07-06" version="1">MKFAEQLAREAFPPWRTHYIKYGLLKAELKNRQADHEWNEEDEKYFTRMLEQELDNVYNTVVIKLEDINSRIKYCDATIQTLKNSQSWSSDESWESTETILTETLFDLNDLAKFIRLNYTGFRKIIKKHDRWATIKLANGFVPQLRDKPLDTQQLDVPIVYISNLKDICNRRGKPHAGNAAAGGDQLNFERATSKYWIHPDNINEVKSIIMMHLPVLIFDSEKKFEPDDSAISSIYFDSPEFDLYTDRLQRDDNGEAIRFRWYGPTSSKSVFVERKTHHASWLNGKSIKDRFRLDTDDVQRFVKGELTAETIVRRLEAKGDMDKVTLDNIYFIAEGIQESIKNKNLAPVCRVFYNRTAFQIPGDQRVRISLDTNLTFIREDNLDGMQRRGQDEWRRSDIGINYPFNGIPKSDIAEFPHGVLETKLQTHLNQQPPEWLTKLLESHLVHEVTRFSKYLHGVAYLFPESIPLVPWWLAELEQDIRKPRSTNFGLSRSPSFRPMINGEYGIAWEAEQNRMKATSSIQLGEKIDKKVVIQDENCRLDIPDSNGNTRKRSRFSTFLAKRWGADTLDTMVVDGSGRVKTKKIKIEPKVYFANERTFISWLQFAALLLAVALSLLNFGDPRTSYAGAVFIGIAVCVCFYALYRFEKRAWMLNNNVKGRYDDMIGPAVLCVFLVGALVVNLYLRFTTPKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PLR2</accession>
    <name>A0A162PLR2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_168456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD74047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292087.1">
        <property type="nucleotide sequence ID" value="XM_018435871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PLR2"/>
    <dbReference type="GeneID" id="28996777"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168456"/>
    <dbReference type="InParanoid" id="A0A162PLR2"/>
    <dbReference type="OrthoDB" id="2260752at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="759"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="784" mass="87018" checksum="FB12D95A8962234F" modified="2016-07-06" version="1">MSQQSAVNSTIVSGEETARVNSGVITPPSAAGSADHDGDTVMTPLCSEDSAFDSEEGSSGSDAGRSGYEGANSPRIYLGNSGVRVNNNLVATVEMLLASAEEDLNTKKGNYYAALGHYLGVSKRDPTSTAAKSASKGAKEAQVLFAEAEQILKDLKASTAPASKPHDKRSTLVPSNLPFLQLRSEGPLVKANRDVFDSVYDFCQEFTTVLEAHSLSLDSCWERLLPTCLNKEERSWFEDKLKGKAYNWKKAESILLDHYDTPFHKFLNMGRVWCMKQGKGESARFFGAKFQKFRRQASLDDGVQLVLCFWWNLRPEVREACLIPLSANYGTKMPSKIEDIISLVSVSTSDSTALLHNPANGTAASSWSSFAAHNGASSLSAGSNKGKKRSFSRERGSQSPKKAWDFKKAMKDGICFSCKAPWVKGHSCPEREKYLTKVSRMAVRSSAGRPARASTVVEGSPSLSWSEYQDNTSALAKMALDCKYNLKDMVIKRDFKNMSTNITFPILANNSIRIISLLDCGATFSSVDKNFCLKNGIAISYINHINKDLLNKNNVHKYFIRLADSNTQIKRIGTCVISVTCNSKTIQREFEVMNLTNSHEYDFSIGTDYMSSLGIGIYGLPLSYDDADSSEERREADRRFNNKSDLLESIERENERKENNPAVGPKQFENAMDYIRPFIKDNQDIPKGSFCTIPESVVCLDTPENATAFRSPYPIPYKMQGVVDEQEYWQRIGEAPEGIKDINKANKKLLKDMKVAYSAPKENSGTKRKNYAKTAYQKKKRSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PPN6</accession>
    <name>A0A162PPN6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_167163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292857.1">
        <property type="nucleotide sequence ID" value="XM_018435576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PPN6"/>
    <dbReference type="GeneID" id="28996482"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167163"/>
    <dbReference type="InParanoid" id="A0A162PPN6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="109" mass="12241" checksum="8BEA4D0FEEF0A203" modified="2016-07-06" version="1">MYSSTNSKRGEQIQMPMGANSVGNGCKFNFYGSQSDVNRPIGNVKIFYPKKSNITGCLQFPILDTNVYSDTFTITKIKRIYVSPPEIFVIILGENWHLSNMIGLEAKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PPV6</accession>
    <name>A0A162PPV6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_167208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292907.1">
        <property type="nucleotide sequence ID" value="XM_018435594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PPV6"/>
    <dbReference type="GeneID" id="28996500"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167208"/>
    <dbReference type="InParanoid" id="A0A162PPV6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="43927" checksum="9A9453747202D585" modified="2016-07-06" version="1">MSGVEAASLELFSMFIENNVSCNVFDKCVKMMNKYMAECGLSVINSLMSYYKIDTLLRQEYTGRPVMDDMCKKESNGKRKAVDWIDFLLFVVPTIVIDHFVFDRTKAAVMKLVTACRIAQQWRITAANIQETEEAIGCWHAFLHCEIKEKRLKPTVFVMIQHILVHLGYMMWEMSPLRAYSCRPIERTIGVYSTAIKLRKKSGKNMENLLLRKAAINHCLGCWPVICGKNDRRTSNFEATRSSLAELATAIGIECQNLVRSLVPFWAREGIVSFEENDEVVCANKMWKDLVVYRAWSSVDSRHGRANNLAVLNNAREVTRLFAAIDYLSDVQRVNQNLFPAWDSLASDLVKVVDVKSIKGIAGLVHDPNNKAIRHIIWSSPKYNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PQB8</accession>
    <name>A0A162PQB8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_146921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD71936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289976.1">
        <property type="nucleotide sequence ID" value="XM_018431754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PQB8"/>
    <dbReference type="STRING" id="763407.A0A162PQB8"/>
    <dbReference type="GeneID" id="28992660"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146921"/>
    <dbReference type="InParanoid" id="A0A162PQB8"/>
    <dbReference type="OrthoDB" id="2382535at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD71936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="339" mass="38468" checksum="E304A0F6CFA5764C" modified="2016-07-06" version="1">MSDTTTTKNTGFRKICHDLESNQVQRLAMSWCPVPKSQSAQLVVRRFIVMCRPGYERLTSTCHNKRARYEDLERSERNVSVQRNLMDIDFETTSNQQTGPMEAMGGQTSSPVWEGAPISDNEIAFSNESNGKSSDGDENDNDEKSNGNEESEDNEENIVEIEVKEFNNKDLFATPNMPENPVHRFIATFVVMFASCYVVNKGAVILIKFINKLLSIYKQDFQLPVRLSGLQSITGFSAMTKEIKRFVVCQNCHKVYEESVSAPLNCDFVKLGAHTTCNCKLMVQSLSGDLVAKKSYVYQSLTHALKILFLRPNFEQKIMHWNQEFKITDTLCDVYDGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PX90</accession>
    <name>A0A162PX90_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_165347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294887.1">
        <property type="nucleotide sequence ID" value="XM_018435210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PX90"/>
    <dbReference type="GeneID" id="28996116"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165347"/>
    <dbReference type="InParanoid" id="A0A162PX90"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="103" mass="11905" checksum="B8609B0E83CB8435" modified="2016-07-06" version="1">MSGHFSSDCTYAIQKDMWFIKWGMNAKDLGFIVKKMSVLLIKKFKNGLEFDTRQFLAENCEHFAKAIYKKTKTYSSVIGFIDGILQKLCCPKSEEEQKTLYNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PXR8</accession>
    <name>A0A162PXR8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein transport protein BOS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_77196</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the BOS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294997.1">
        <property type="nucleotide sequence ID" value="XM_018443237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PXR8"/>
    <dbReference type="FunCoup" id="A0A162PXR8">
        <property type="interactions" value="668"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162PXR8"/>
    <dbReference type="GeneID" id="29004143"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_77196"/>
    <dbReference type="InParanoid" id="A0A162PXR8"/>
    <dbReference type="OrthoDB" id="158360at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15863">
        <property type="entry name" value="SNARE_GS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027027">
        <property type="entry name" value="GOSR2/Membrin/Bos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF1">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028865">
        <property type="entry name" value="Membrin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD76957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="216" mass="24907" checksum="B1CBC45C6EEEF0F7" modified="2016-07-06" version="1" fragment="single">MNSLYNHALKQSNALQRDINKFASGQDASVGLQGQISVSFSSFQRSIDDYENIAKREMVAVKKETALTRVTKFRHDLREMKTQFETIKRQQENQQNEQNRDSLLARRPNKTSAPEYPYQPMSRLEAATRDTSFNDSTESQLDDFITQAHTILENLTDQHSILKKTQKKLLDAANTLGLSQNVIRYIERRTSQDKWIFFGGVVITVLLMWAIAHYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q021</accession>
    <name>A0A162Q021_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_59455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293966.1">
        <property type="nucleotide sequence ID" value="XM_018440497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q021"/>
    <dbReference type="GeneID" id="29001403"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_59455"/>
    <dbReference type="InParanoid" id="A0A162Q021"/>
    <dbReference type="OrthoDB" id="2233065at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="145" mass="16352" checksum="513D539C15B6B1F5" modified="2016-07-06" version="1">MCRPPGISDCTNPISCLSCEEVDANVSSLQALPMFLIEKSPTLYVHSRPEHSTVRTLCRLTAERPEFETEQRENLVHAVDFICTNNEKSWNKVDASLVDIPGTLKARKIVFHALEFNFSAKQKYSDMEGSGRDRCYNGCMADMCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q3F4</accession>
    <name>A0A162Q3F4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cornichon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_27482</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cornichon family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297706.1">
        <property type="nucleotide sequence ID" value="XM_018439913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q3F4"/>
    <dbReference type="FunCoup" id="A0A162Q3F4">
        <property type="interactions" value="594"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162Q3F4"/>
    <dbReference type="GeneID" id="29000819"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_27482"/>
    <dbReference type="InParanoid" id="A0A162Q3F4"/>
    <dbReference type="OrthoDB" id="434393at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033466">
        <property type="entry name" value="Cornichon_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01398">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01340">
        <property type="entry name" value="CORNICHON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD79666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15967" checksum="9C6229E17A750831" modified="2016-07-06" version="1">MVGEAMLFLFAVIMAALLLFSMVFFVIMFSDLECDYVNPIDLCNKLNQFVLPEMGAHAFLFFMFLVNGSWTAMILNLPLVAYNIRKVTNNRHMYDATEIFRTLSTHKKECFFKLAFYLICFFYFLYRMIVALIAADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q896</accession>
    <name>A0A162Q896_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3752 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_61981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298976.1">
        <property type="nucleotide sequence ID" value="XM_018440884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q896"/>
    <dbReference type="STRING" id="763407.A0A162Q896"/>
    <dbReference type="GeneID" id="29001790"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61981"/>
    <dbReference type="InParanoid" id="A0A162Q896"/>
    <dbReference type="OrthoDB" id="73491at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022226">
        <property type="entry name" value="DUF3752"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046331">
        <property type="entry name" value="GPAM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370:SF1">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12572">
        <property type="entry name" value="DUF3752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3752" evidence="2">
        <location>
            <begin position="183"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD80936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="323" mass="36869" checksum="7A44FC329D88E440" modified="2016-07-06" version="1">MIGPEIPSHLLQPKQSPEPSPADESSTVSIGPVLPPHLANRSSSVPETQLPSVPTVPAVDTAPASDDEDAFLPELPPDLLEQRKKTEPKPQIEDRNNNNNNKQQHRRRRPVGPAMPSCPLSVATYEDAEDIGPVLPSSYDPEKMAVQSTMADIEERARQSKEQMEKKDDPSGKIERPEWMLLPPEVDYLKAADSGRSRTFNNRQLSDRDRDNSGWTESPSDKKNKKRKEAKDDVPRASLEQERIIKHNIEKHNRSERPLSLMEMHQKKRKVNREMEDVRNRPFDREKDLKGYKPMDKKQKKEFMRQSGILDDRFGSSSRGSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T446</accession>
    <name>A0A162T446_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_137445</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441005">
        <property type="protein sequence ID" value="OAD66132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284172.1">
        <property type="nucleotide sequence ID" value="XM_018429856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T446"/>
    <dbReference type="STRING" id="763407.A0A162T446"/>
    <dbReference type="GeneID" id="28990762"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_137445"/>
    <dbReference type="InParanoid" id="A0A162T446"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF26">
        <property type="entry name" value="OS04G0435100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD66132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="57356" checksum="BE1B17003B16F0C3" modified="2016-07-06" version="1">MSKLKPQVAQVESLSEKNGDSDISSSNIEHVSGLDYDAQRLQEFGYKQEFKREISMIVLAGFGFSTMAVLPNWLVGFGASLVAGGPSSLWWTWITVSPFVMCIGLSMAEVISAYPLAGGIYSWCYMLSNEEWGPFTSWVSGYVNLSGMLATNMTLAWSCADFVFEIANIHSGVEISSQGAHVGLYCGMLIAGALYSYLGLKCSSYLNVFMMYWVLFGTLIVIITIPAMSPTHTSGEWVFTEFINRTGYDNDGMAFLLGLLQAGWCLIGYGAGAQIVEGTKNADKTAPRGIIICVAGSIIQGAALILPVMFSIQDVEELIDSPYPIATFFERATSRPVAIFFMVILLVTQFGALCNNTFAMGQLIWALARDRCIPQANFWYSLDSRKIPVRGLMLQLLICIVAIMPSFGSPVYWQAIMSTAVICVNVSYGLPFVCRLIWKRNTMQKGPFTLGKFSIPLNIISIVWIIFFAVILCLPQTYPVTPETMNWSCVMISAVVIFATVFWFAAGRYTYKGPMQNIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TGN1</accession>
    <name>A0A162TGN1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
            <ecNumber evidence="4 12">2.4.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Asparagine-linked glycosylation protein 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ALG13</name>
        <name evidence="14" type="ORF">PHYBLDRAFT_151932</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UDP-N-acetyl-alpha-D-glucosamine = an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23380"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19510"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57269"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.4.1.141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Heterodimer with ALG14 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.141" evidence="4 12"/>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD66993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285033.1">
        <property type="nucleotide sequence ID" value="XM_018432791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TGN1"/>
    <dbReference type="FunCoup" id="A0A162TGN1">
        <property type="interactions" value="138"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TGN1"/>
    <dbReference type="GeneID" id="28993697"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151932"/>
    <dbReference type="InParanoid" id="A0A162TGN1"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039042">
        <property type="entry name" value="Alg13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867:SF6">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLDIPHOSPHODOLICHOL N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD66993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="167" mass="18502" checksum="ACA1FBEB94455F9B" modified="2016-07-06" version="1">MSIFVTVGSTGFDDLVEAATSASFLSFLEMRGYRNLVIQYGSSETIYSRTTFPTISNITVTGYSYKSSIEEDMKQADIIVSHAGSGTLLQALRLDNKKVVVVVNTSLMDNHQREIADVMESKNYVVATNPSNLSDAVETIQKRSIDKFPHANINHFGDLLDEFMGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TH51</accession>
    <name>A0A162TH51_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase catalytic subunit A</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHYBLDRAFT_128283</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="KV441025">
        <property type="protein sequence ID" value="OAD67103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285143.1">
        <property type="nucleotide sequence ID" value="XM_018429212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TH51"/>
    <dbReference type="FunCoup" id="A0A162TH51">
        <property type="interactions" value="436"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TH51"/>
    <dbReference type="GeneID" id="28990118"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_128283"/>
    <dbReference type="InParanoid" id="A0A162TH51"/>
    <dbReference type="OrthoDB" id="1676488at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055082">
        <property type="term" value="P:intracellular chemical homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18119">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000008">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000052">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005725">
        <property type="entry name" value="ATPase_V1-cplx_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003220">
        <property type="entry name" value="PRK04192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01042">
        <property type="entry name" value="V-ATPase_V1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="27"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="ATPsynthase alpha/beta subunit barrel-sandwich" evidence="16">
        <location>
            <begin position="130"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="14">
        <location>
            <begin position="236"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="17">
        <location>
            <begin position="468"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAD67103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="619" mass="68589" checksum="7DAD69F0B94D031B" modified="2016-07-06" version="1">MAGALENAQNEMRKIRDHERESDFGAIYSVSGPVVVAENMYGSAMYELVRVGHSELVGEVIRIDGDKTTIQVYEETGGLTVGDPVLRSGKPLSVELGPGLMSNIYDGIQRPLKAIQEASQSIYIPRGIATPALDKGFGWDFEPLNFEVGDHITGGDIYGKVWENSLVTIHNIMLPPKARGTITYIAPKGQYTIQDVVLETEFEGETTEYTMKQLWPVRSPRPVAEKLTANHPLLTGQRVLDSLFPCVQGGTTAIPGAFGCGKTVISQSLSKYSNSDIIIYVGCGERGNEMAEVLMDFPELSIDINGRKESIMKRTTLVANTSNMPVAAREASIYTGITLSEYFRDQGKNVAMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGKTTCLGNPSREGSVTVVGAVSPPGGDFSDPVTASTLGIVQVFWGLDKKLAQRKHFPSVNWSLSYSKYMKVLEPFYEQSDPEYISLRDKCKEILQMEENLSEIVQLVGKSGLNESDKITLDVAQIIKDDFLQQNGYSSYDRFCPFFKTTWMLRNLIGFYTQATHTVEASNGQVSWSKIRESMSDIVYKLSSMKFEDPADGEEVLVQKYSALYKEIEAKFRDFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TPN8</accession>
    <name>A0A162TPN8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_150393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286843.1">
        <property type="nucleotide sequence ID" value="XM_018432471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TPN8"/>
    <dbReference type="STRING" id="763407.A0A162TPN8"/>
    <dbReference type="GeneID" id="28993377"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150393"/>
    <dbReference type="InParanoid" id="A0A162TPN8"/>
    <dbReference type="OrthoDB" id="2283106at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD68803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="303" mass="32803" checksum="3BCFBE29864808B9" modified="2016-07-06" version="1">MSTLLPSSVMQGMSPDLASFLGNMQAQFMSLQQRTNELESLAATNAKLTAQLVNAEKLIADLRSQLASQGNCQITTNASTSSAPTTPKEPGTEASTWATTAAAAHNSVVVPTALSVCKTPRPPSVRQVAASARMFAIPTGPKGYQYVYIPRSRRLTHREVRNSLKTLGVDTGRILDINFPAKDVVGILVHNQYAEKFQTTLTTVAIEILDAFDPLDPKNIADPKYKSLSDSELEEVAAELHSDRCMKALKYLRPHVAVPVGHFFCDQGWISKEDIPVHSVSGPGAGIHDFQSPSRRTSVAMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TYS4</accession>
    <name>A0A162TYS4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_148127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288943.1">
        <property type="nucleotide sequence ID" value="XM_018432014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TYS4"/>
    <dbReference type="GeneID" id="28992920"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148127"/>
    <dbReference type="InParanoid" id="A0A162TYS4"/>
    <dbReference type="OrthoDB" id="10528970at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="409" mass="45911" checksum="7E5CD56D73C185AC" modified="2016-07-06" version="1">MSYLYSCEQIQDGEGTSVTSVLVQEIQGEPEISPSSLLKSTNSAYEISDADTDWSDMAAFENEDDLNFSDTDEDDIEARWFPSLLQESFIQPLDDSDDEEALDSSVLVESAVIVSSADVAEIIESEYSDDGDGGLSTGKSGSPKSSDRRKSRKLWRDKPEQEKQIAQQQSLVPIERHKIISAVLSPFFFKDNNNNKRFGIKSVSILKVVFSYDAFYYNNIGSVLFCNPTRLHASRSLSGQLLSQRMKIGLIFVSFESHKTKFDPPNRLQKKMEDKGRSWTAQNNIREVTRRSSGCGCNGAGRTSRLDQFPRTFRILSDREEMVETCTGTKGWWGLDRKKKPLEGELGNHGDDREWYKKSLDVRGVEIQGIYENQAVGSVKKVPTISNDSEPEEGDGGRVNSYGHELEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U9N4</accession>
    <name>A0A162U9N4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_67474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292652.1">
        <property type="nucleotide sequence ID" value="XM_018441800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U9N4"/>
    <dbReference type="GeneID" id="29002706"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_67474"/>
    <dbReference type="InParanoid" id="A0A162U9N4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="103" mass="12486" checksum="647BC9EDC6AB9804" modified="2016-07-06" version="1">MVNSAIFLLLCPNFEVIYVWKSVKNFDDYFRLHHNVITLESIQQACLLRKDLVSKFDKIPTLNYYCYLYYFGLEKLYAWGQKIIMFVSYNYAPKNALMYRILW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UBR2</accession>
    <name>A0A162UBR2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_67805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293082.1">
        <property type="nucleotide sequence ID" value="XM_018441853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UBR2"/>
    <dbReference type="GeneID" id="29002759"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_67805"/>
    <dbReference type="InParanoid" id="A0A162UBR2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="280" mass="32211" checksum="82112347260B72CC" modified="2016-07-06" version="1">MSDRFKMYVSILFSKTSIIYILDSSSSTENYLYIDISHQYYQPNQNHKPDFRVIELSQARSGSLDAFRYPTTLIYASFDLGTVKEAVYNLAAKVDNMGQRKNTSLNQTTKGTNKRISYFFIVIMISTIVNFLITRGYKSRSNYTQETGSSSNIKFFEGDIISSDVIQNGICPYTPRSIIIDKDDMLILISSINTCVSSNSGRHKTRWLKVNGDFQESMCTFWFGTGIKTLLKYVIKGQAKKSGCFNVKRKVRKEYIYRNYNALPNRLPSNEILFRALEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UJI1</accession>
    <name>A0A162UJI1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_143982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293773.1">
        <property type="nucleotide sequence ID" value="XM_018431122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UJI1"/>
    <dbReference type="GeneID" id="28992028"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143982"/>
    <dbReference type="InParanoid" id="A0A162UJI1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="36384" checksum="5CA67ED8B10C4114" modified="2016-07-06" version="1">MTNTRRERAIALRPVEITNQQLMEILSTVRADMSTVKGQIGNVEQTLTNMNGRIGVLATTSTNTISAIDSLARTPLAAPVRAELTVAAPVVISNHEPTREESNAVYAHIHNLMWKPKLSLRTPENILANNLKPRWDTNVAFNKSPNREIAERLLSNLERRFGSSSMRRSDLRKRLHTNFTSRTRRERMSDDEIAETNALTRRAARADDNECRRVLAYKDNKEAIDLVMLRDCANTLQKAVMSDGESADEMDEDGIKYVIHIVQPGWRSDECNRFIALVDTYAVQAMGSSANQRIRRITTSVSNSAVPDNISPNFPRWALRDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UWS7</accession>
    <name>A0A162UWS7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CHHC U11-48K-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_163590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296523.1">
        <property type="nucleotide sequence ID" value="XM_018434837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UWS7"/>
    <dbReference type="STRING" id="763407.A0A162UWS7"/>
    <dbReference type="GeneID" id="28995743"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_163590"/>
    <dbReference type="InParanoid" id="A0A162UWS7"/>
    <dbReference type="OrthoDB" id="69229at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022776">
        <property type="entry name" value="TRM13/UPF0224_CHHC_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051591">
        <property type="entry name" value="UPF0224_FAM112_RNA_Proc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21402">
        <property type="entry name" value="GAMETOCYTE SPECIFIC FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21402:SF10">
        <property type="entry name" value="U11_U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 48 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05253">
        <property type="entry name" value="zf-U11-48K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51800">
        <property type="entry name" value="ZF_CHHC_U11_48K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHHC U11-48K-type" evidence="4">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD78483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="251" mass="29190" checksum="89C3A84A769EDE5A" modified="2016-07-06" version="1">MSREQRLKQLEDAKQRFLKKDESLDKILGSLGWNRENVKQWQETQAKLKTCPFNRRHRVPAASFKAHSRSCLLKSRGIRGISNEPEPPSSLFYYQKAPFVVSFVDKNTQFSDTAGNGYAVYPLPVSGSRPPTAFEALEPTPMSVQARDREYVECVLKAQEIRQRNQVKHLDLDRAGFEQVVEKAKQLQAQKEVQANEVSTSQFAENRDYRRRPKAYRVSLTQRTPTQIQKQLVEAYMQDFELWQKYKQESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V0G8</accession>
    <name>A0A162V0G8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_139219</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297223.1">
        <property type="nucleotide sequence ID" value="XM_018430181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V0G8"/>
    <dbReference type="STRING" id="763407.A0A162V0G8"/>
    <dbReference type="GeneID" id="28991087"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139219"/>
    <dbReference type="InParanoid" id="A0A162V0G8"/>
    <dbReference type="OrthoDB" id="2363417at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007840294" description="Galactose oxidase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="376"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD79183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="54485" checksum="7B50805447EBE4B3" modified="2016-07-06" version="1">MLRLILLSLSIISVSGYTPAGRTSQVCQFVRNAIYCFGGGHNNNGLFTADYPEHLYLDLSKSLELDNFAYDAWKDISISSDGFELEKSCNAASTILPDDRYIIFGGGNCMNYVTLSNNTVVFDAKTQKWTGYNQTAVQQNYEGFGVYLNRTNKALFWGGRSTTGVQNTNINPIFYSFDATNPSVFFTFTTPLGDGMKMPGSGQSVLGPDEKTIYHFGGWEGFSDPAAANFTTYASSFRTISLYNTDTSIWSTVTVVPDIIPSNRTMMTATLLPNSTSFLIYGGVTHLSAAITYPCEDYAYLFDTLSNSWSVANISSENGAGPRFGHSAVLHPNGDLFIIFGVDRSNTNKNDYHILDTSNIQSFTWKTAFTPNSFLESPSTNSTKSTGSGSSTTTGSKSGTTKDGISGGAIAGIVVGCVAAIAIAGILFWFLRRKEADKKDTIYEEVNVSSIKPPLNPTSGIQTENIDIERRINESNILVVDNNKPDIPRIMMEPVKPQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V0R3</accession>
    <name>A0A162V0R3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_162308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297272.1">
        <property type="nucleotide sequence ID" value="XM_018434597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V0R3"/>
    <dbReference type="GeneID" id="28995503"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162308"/>
    <dbReference type="InParanoid" id="A0A162V0R3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD79232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="130" mass="14879" checksum="477F1D4DDF7FE3A0" modified="2016-07-06" version="1">MCGYRFLKGRQKKSLGTCTNQSTILVLELSKALTSPYFYINMIQEISLIGIQMLNKGTILFQHNNKLIAESISCHLEYMQKGSVLGIIPKPTKQLNYSNKLGEFKVYRSTICTLIKAHFNLSPEQKRQFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V5M5</accession>
    <name>A0A162V5M5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH dehydrogenase Fe-S protein subunit 6 NDUFS6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Ndufs6</name>
        <name evidence="2" type="ORF">PHYBLDRAFT_35566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298212.1">
        <property type="nucleotide sequence ID" value="XM_018440056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V5M5"/>
    <dbReference type="STRING" id="763407.A0A162V5M5"/>
    <dbReference type="GeneID" id="29000962"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_35566"/>
    <dbReference type="InParanoid" id="A0A162V5M5"/>
    <dbReference type="OrthoDB" id="307899at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.40:FF:000003">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.40">
        <property type="entry name" value="q5lls5 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019401">
        <property type="entry name" value="Znf_CHCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10276">
        <property type="entry name" value="zf-CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger CHCC-type" evidence="1">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="129" mass="14217" checksum="C431410E11BEF597" modified="2016-07-06" version="1">MLRSTIAAIRRTSIRSYTTSLEQTTKQAGIQIQQAPNFVGTWSKSQRPKEEAMSGPRFEQIDLATQPNAMAAIELIAEEPIQFVSERVTSCNGGGGPLGHPKVYINLDKPGAHACGYCGIRFEMNHHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162VAK6</accession>
    <name>A0A162VAK6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_72764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299292.1">
        <property type="nucleotide sequence ID" value="XM_018442711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162VAK6"/>
    <dbReference type="STRING" id="763407.A0A162VAK6"/>
    <dbReference type="GeneID" id="29003617"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_72764"/>
    <dbReference type="InParanoid" id="A0A162VAK6"/>
    <dbReference type="OrthoDB" id="2439011at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="326" mass="37925" checksum="16427653AAC91004" modified="2016-07-06" version="1">MPGPKEPKTDEINNYLEPMVDELIQLYCGIRILTFKSPAGEVIRAALMMVACDIPAARKTGGFTAHNSTCVCFKCNCHFTRLDSTNKVDFRGFCGISECIYCLTSVGVTIMTSSHKSALGLPTKLAPYRSDTVYLALLHYPNMNMLLYVINPTSEYLDHHRFKESEWCHCNYEENRLHAEEWKSTVIISERQHLEIEKWCSMWIECGVLRDRDFTAMQKIADKMIVPRRYTALKSKIDKKIAFMKVDEWKLWVLVYSPVMLKSVLSSLHFNNWIDFVYACRHLVKPSITFDDINTNHRHLENFCEKCNEIYTIMILTCNMHLRLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162W8C2</accession>
    <name>A0A162W8C2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_71015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441029">
        <property type="protein sequence ID" value="OAD65315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283355.1">
        <property type="nucleotide sequence ID" value="XM_018442392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162W8C2"/>
    <dbReference type="STRING" id="763407.A0A162W8C2"/>
    <dbReference type="GeneID" id="29003298"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71015"/>
    <dbReference type="InParanoid" id="A0A162W8C2"/>
    <dbReference type="OrthoDB" id="2506088at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="227" mass="25760" checksum="04AA8E778E83ED71" modified="2016-07-06" version="1">MLALFDGYLIEQGSDSEGYALHKVQSSSVTYGIKYLVSAWLSSIFYSYPKNWSSSGETSLNPMHHGLFSFNFRRSFITPLAIFSDDISGNLTKTHGMYSNMLVNFPAISYSMRNRRKNNFFVTAVSQQARFKLTHLMPIQATDLKALENGVDMYSSTYDETITVCASLLFITANNAQHTELVGLKHLTSNFLCKRCYSQNLSRFGFDNFGISLFYPTESLNFENPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162X1H8</accession>
    <name>A0A162X1H8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_169884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD71975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290015.1">
        <property type="nucleotide sequence ID" value="XM_018436193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162X1H8"/>
    <dbReference type="GeneID" id="28997099"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169884"/>
    <dbReference type="InParanoid" id="A0A162X1H8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="109" mass="12394" checksum="C86A8B31CC5B43AA" modified="2016-07-06" version="1">MSCLNRDGLNDFQFAPLILSVSQDFSGLLTKTYILGGFTKCHWSLSRSSFFDYTPTLILYRQTNNVIVFCVCQLFCFLNCLAKKACRSKQWNTVGVDCTRGGPMDVRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162X9I6</accession>
    <name>A0A162X9I6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_65994</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291425.1">
        <property type="nucleotide sequence ID" value="XM_018441567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162X9I6"/>
    <dbReference type="FunCoup" id="A0A162X9I6">
        <property type="interactions" value="286"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162X9I6"/>
    <dbReference type="GeneID" id="29002473"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65994"/>
    <dbReference type="InParanoid" id="A0A162X9I6"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF43">
        <property type="entry name" value="PALMITOYLTRANSFERASE APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="221"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD73385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="427" mass="48092" checksum="E92BDA434AD26D1E" modified="2016-07-06" version="1">MQGRGQDTASSYSASQTHGRPHTNSSAFSSIPTPITSSIDNPDLNPEQSKQHQQHGPESTTTTAAAATESQNPANTVQDNNPPDQPRTQQVNLQVMHKTAVKNYQVFPGNIKFFCGGRFITSKAYWAFGVSIGVLLIPAILCPWYWTHLSPAIPIIFAYTFILTFSSMMRTAWVDPGIIPRNLNKMPPIASSINENSGILPDPLQFMTPPIKNVMIKGKQVELNYCETCLIYRPPRSSHCRDCDNCVELYDHHCIWLNNCIGKRNYRTFFVFIVTGTFLSVFVFAFSLAHLMLLYFNDPEQREFKTIANNAPVSLLLTVFSFLFIFPIGYLTAFHCYIVCAGVTTHEKLKIDGRPFPNDKPMFDFGSSFCNFIHSVCQPRSKSYIARRKFVTHPLPLQTIIMTTDSAGNRYSTIQRNTLMSQTPLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XE77</accession>
    <name>A0A162XE77_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="17">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PHYBLDRAFT_177452</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 17">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="17"/>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292315.1">
        <property type="nucleotide sequence ID" value="XM_018437887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XE77"/>
    <dbReference type="STRING" id="763407.A0A162XE77"/>
    <dbReference type="GeneID" id="28998793"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_177452"/>
    <dbReference type="InParanoid" id="A0A162XE77"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000014">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
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    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
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    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF180">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="976"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1007"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1058"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1092"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1117"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1159"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="27"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="20">
        <location>
            <begin position="945"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="461"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="14">
        <location>
            <position position="438"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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        <location>
            <position position="439"/>
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        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
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            <dbReference type="ARBA" id="ARBA00008109"/>
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    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
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    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OAD74275.1"/>
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    <evidence type="ECO:0000313" key="22">
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    <sequence length="1209" mass="136552" checksum="27AE5A62D1DFE1F5" modified="2016-07-06" version="1">MSLLRSIQEWRETLWKKQPKKKPRGKDEHYEEVIRYTTNRIRTSKYTILSFVPKNLFEQFRRAANIYFLGMAILQMLPTFGVKSPALTLLPICTVVVITALKDAFEDLERHKVDARYNSTPTHTLLGYNNTNHPQPVEKNKNKINAQESSFSHTTARGVFEPSLSRDVRVGDFILLRNGESLPADAVLLASAGASNICFVETKDLDGETNLKPRQGIEEYSSLQSGQACLDNCHFYLESGPPNPDLYAFEGTLVMLTKTLESWSETKKIPISTDNLLLRGHVIRNTPWVIAVVLFTGTDTKIMLNSGETPSKRSQIERQMNKEIILAFVVLFILSFVCAAMGGVMKLQDDKSGATSLYSRQTGSAAYVGFENFWASLIIFQNIIPISLYVSIEFVKTFQAYFIWNDREMWDESTGQPCIPKSWNLSDDLGQIEYVFSDKTGTLTQNVMEFRECSVGGRRYGNNGFQPESEGARGARLRLDPESTAPERPPELFDDYLQSMKTIFEPRYATQDPELLSFADPALFKDLEPSLDSRQPLVDFFTLLAICHTVVRKNDPKDSPIQVPAAAAIRETLREQGRKIQANFGIKKKAGQGKAFAALPLTKVDQTVETQLMYKAESPDEAALVTAARNCGFAFVGRQGNRATLDVLGESYEYEVIRVLAFTSTRKRMSVVVRRPAPWNDVVLYCKGADNVIIARLAPGQEEYSQQTQEDLDSFSNDGLRTLVLGWRVLDPKYFETWNESMEKAMTSTENRSEKVDQLQEEIEQDLILLGATGIEDKLQEGVPETIEDLRHAGMKIWVLTGDKLETAINIGYASNLLTKDMHIWTLRVEDVDSLDNLAAKLVPTDNLEDGEQEENALVLEGSALAKLFETDETRDKLLQVALLCKSVVCCRVSPLQKALVVEMVRKGRNAVTLAVGDGANDVSMIQAANVGVGIAGKEGVQASMASDYSIGQFRFLGQLLLVQGHWSYGRIAEMVLNFFFKNVFWVFPSLWYQIYSRFSGNIFYDYSFLQLYNIIFTLAPVIIMGCTDQDITAPCLRKYPQTYEVGIHRELYTKTRFCLYFLDGIWQSLVVFYCFFFLYEPHPSDHGSASMLQLSTGVAVSAIVLANLVPGFNTYYWTWIMFLGVGAELVINFAWIAVYGSFSSTTMYGIAPMLYSRGSFWLTGLLSVVFALIPRYTISFVRQWWYSDVISTVRQREYWERRSLKKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YKF1</accession>
    <name>A0A162YKF1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_161918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299345.1">
        <property type="nucleotide sequence ID" value="XM_018434532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YKF1"/>
    <dbReference type="GeneID" id="28995438"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161918"/>
    <dbReference type="InParanoid" id="A0A162YKF1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="155" mass="17779" checksum="3C2B0C8E29848798" modified="2016-07-06" version="1">MALYFSAAVIARIQRFADDIPLPPEYTVLFEKVASEFLYMKAGVAQVLSEYHLPCLQCIDNDYPPALPFDLLMFQQVVNSLWYNVIGTKTSPPTTMPLKLQNLNTMKIVDDISKFPGQIEYIFTRHQDWIKPLVGFYQNKITESDITISNEKNHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZN49</accession>
    <name>A0A162ZN49_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_173902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286031.1">
        <property type="nucleotide sequence ID" value="XM_018437126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZN49"/>
    <dbReference type="GeneID" id="28998032"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_173902"/>
    <dbReference type="InParanoid" id="A0A162ZN49"/>
    <dbReference type="OrthoDB" id="2289822at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="308" mass="34568" checksum="18EF35CCFDB6156A" modified="2016-07-06" version="1">MSTITKLSHHECSICHKCYTNKKLVAKCEVQCLEKYDIEHEDSMENDLTIMDVTENVIDNTPPQLAYDFSAPVPVSGYADAKNLKLMKIIKEFDISQKAHISLAKDFNEILSKSSEISYRVLTPYLGTKLLSRFLGVDEETYHICCNRCMLYNNNQQTECPHCDKAYYNTGKRSQDTSENPIPASTMIQLPLGRQLALALMKCMTFVTALANRSGGSCVASMEKIILSFSLAAQKEIGTAMVSPRRSILTSFHGAWINIATRSGYFRAVDWADFILFVIPTLVAERVRDQAAHKALLDLVQICNLLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZP86</accession>
    <name>A0A162ZP86_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Heat shock protein 70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_127826</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286231.1">
        <property type="nucleotide sequence ID" value="XM_018429189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZP86"/>
    <dbReference type="FunCoup" id="A0A162ZP86">
        <property type="interactions" value="393"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162ZP86"/>
    <dbReference type="GeneID" id="28990095"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_127826"/>
    <dbReference type="InParanoid" id="A0A162ZP86"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD68191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="618" mass="67595" checksum="F3CE56E46F3B2871" modified="2016-07-06" version="1">MSAEYEGAIGIDLGTTYSCVGVWESERVEIIANEQGNRTTPSYVAFSDSERLVGDAAKNQAAMNPKNTVFDAKRLIGRRFDDADVKADMKNWPFTVVDQNENPFIQVQFEGETKTYSPQEISSMVLIKMKEIAEAKLGKKVSKAVVTVPAYFNDSQRQATKDAGVIAGLEVLRIINEPTAAAIAYGLDANDKKERNVLIFDLGGGTFDVSLLTISGGVFAVKATAGNTHLGGEDFDNTLVNHFVQEIKRKHKKDISDDARALRRLRSASERAKRTLSSLTQTTVEVDSLFEGVDFQSNITRAKFEEINSTSFNGTVEPVERVLKDAKIDKKNVDEIVLVGGSTRIPKIQSLLQDLFNGKELNKSINPDEAVAYGAAVQAAVLTNQAGNEKTQDLLLLDVVPLSLGVEMQGGIMAVVVPRNSPIPCQKSKVFTTASDNQTTVTFPVYEGERLLTKENNLLGEFSLTGLIPAPRGTPELLCTFDLDANGILKVTAQDKTTGRKADVTISNSTRLSAADIERMVNDAEKNAETDKAREAVVQAKQDLESYVYQVENQVSDPNVNMKIRRGDREAIETALAEAMEMMDISAEDGSADEFKGAQSKLKRAATRAFAHVYSQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZXT4</accession>
    <name>A0A162ZXT4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_78272</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287751.1">
        <property type="nucleotide sequence ID" value="XM_018443349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZXT4"/>
    <dbReference type="FunCoup" id="A0A162ZXT4">
        <property type="interactions" value="236"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162ZXT4"/>
    <dbReference type="GeneID" id="29004254"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_78272"/>
    <dbReference type="InParanoid" id="A0A162ZXT4"/>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="5">
        <location>
            <begin position="137"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD69711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="301" mass="34015" checksum="14D3353471006D43" modified="2016-07-06" version="1">MPRPNLYSSFFSQSFVVCSDPQSYLTGVETSPIHCTEFYGLSSDQDKGVREPCMRRTSSACSDLSRYLQSCSANNKSKWWIGPKRRFSTLSYSDEDDASYHKHSRNERSLSADALFCQETLATPQLTLDERDQSTFPCLTSPLAEDLRSWLPARVAVADKWSLLYSLDQHGCSLSTLYNRIHDKGPCLLVLQNTEDETFGAYLSEPFKVNSKYYGSGECFLWRTDSSNKLHVYPWTMANDYLLYSDQDILAVGGSNGKFGLCLHANLTDGHSQPCLTFNNPALTQDPSFECVGIEFWGFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163A782</accession>
    <name>A0A163A782_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_147287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289581.1">
        <property type="nucleotide sequence ID" value="XM_018431833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163A782"/>
    <dbReference type="GeneID" id="28992739"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_147287"/>
    <dbReference type="InParanoid" id="A0A163A782"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="76" mass="9042" checksum="BBAB0AE20974B0E3" modified="2016-07-06" version="1">MHQRKKNETSRGNHYVIFTCPYRKNRNTIVHFWLVGKVQSFYQCKDSRYSLHFLAFVEIMKEHDAAGHDSSVPTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AEI9</accession>
    <name>A0A163AEI9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_146250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290971.1">
        <property type="nucleotide sequence ID" value="XM_018431610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AEI9"/>
    <dbReference type="GeneID" id="28992516"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146250"/>
    <dbReference type="InParanoid" id="A0A163AEI9"/>
    <dbReference type="OrthoDB" id="2236902at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="158" mass="18183" checksum="BDE9BF82577F0A80" modified="2016-07-06" version="1">MSGNDFTLSPSEQRDGRRIDMLYIPANNATRTSLNVMDATELYPHVMVISSDGFSDKRFRDSTFTKEEPRTFYTHPCQALAKSIRICISRSLFPQLDQTPLDKMIALCHIFFRKQKSILILEKYDDLFVQAIYKVALQVCAIQKDNTSKLNETTLEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AR28</accession>
    <name>A0A163AR28_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_186315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293231.1">
        <property type="nucleotide sequence ID" value="XM_018439219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AR28"/>
    <dbReference type="GeneID" id="29000125"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_186315"/>
    <dbReference type="InParanoid" id="A0A163AR28"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012068361" evidence="1">
        <location>
            <begin position="16"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="817" mass="90557" checksum="3118C54ED336468E" modified="2016-07-06" version="1">MLIVFCMLLVPSVQVKHQGSNQSPRLSGVSKLDEQLLTCYCIFVVSIPSRSSFKVQVEVHGFQVKLQGSGQGPRFSDRGPRFQYPIHPGKASMFRSPSYGHSFYLLLVSAIQVKCEGPDFPAMGIAIDVRRQGSDLPAMVLVIQVNQQDSDLLAMVIAIYVKRPGSDLPTMFTAIRVKRQGPNRPSMVIAIHVKHQEPDPLSMVIVINVKQQGPDQLSMVIVSSYPRQASRFRSPSYGYSTSVQSSRSSGKDPIAWPWVECSAIDIRRQGCDLPAKCSVIQVNQQNSDLPSMCSANHVKCPGSHLPAMVIDCSVIQIKHLGSDCQSMVIVSSHPGQASRFQSPSYGYSVQSSRSSIQVLIANPWLKSPAIQVKHQGSTRPSMVCSAIQVKHQGSDRPSKIICSVIQVKHQGPYRLPMSPAIQVKHQDSDRPCMVIAIQVKHHGSDRPSMVIVIHVKHQGSDHPSMPPAIQVKHEGPDLPSMVIVVQVKVQGFDCPSMCSVIHVKHQGSDHPSMVIAIQIKCQGPDHPSMVISIKQHYGHILTSCNILLVFSHPGQASRFWSPRHDLIYLQSPAIQVKHQDSDLPAMGIVLNPPRSCFMDPDSVRGYRPNSKDQNSNLGYSSNIKDLISNQGYGYTLFSLSLHAFFRIGLVCLRSGYTMKKLFSFQCDRYIHLVRPLVTVGFISLLASQSKPAIMDPISVQCYSVLAVKVPLLSMPMIPNPSPIQSDRATIKDSISIQYDSQGQSIQVYCPLGQTELPKFYYLPSARAEANDQSFDILLGSQQAFNAQLYIKGRRYTRIFKQFTKKLDFPSVYIVKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ARB4</accession>
    <name>A0A163ARB4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="12">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHYBLDRAFT_96428</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="12"/>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293281.1">
        <property type="nucleotide sequence ID" value="XM_018443968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ARB4"/>
    <dbReference type="FunCoup" id="A0A163ARB4">
        <property type="interactions" value="880"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163ARB4"/>
    <dbReference type="GeneID" id="29004873"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_96428"/>
    <dbReference type="InParanoid" id="A0A163ARB4"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18002">
        <property type="entry name" value="DEXQc_INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000006">
        <property type="entry name" value="Putative DNA helicase INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020838">
        <property type="entry name" value="DBINO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031047">
        <property type="entry name" value="DEXQc_INO80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="CHROMATIN-REMODELING ATPASE INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13892">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51413">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DBINO" evidence="17">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="184"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="747"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="5"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAD75241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="888" mass="102958" checksum="DAFD2B898711BA0C" modified="2016-07-06" version="1" fragment="single">MKEMLVFWKKNEKEERELRKKAEKEALERLRQEEERREAQRQARKLNFLITQTELYSHFIGRKIKQDMGDDEDAAMMPGGNMSMDLEGDGDLDIGGDDQEQLGEIDFDEDDDEKLREQARRGAQNALAKQREATRAFDESALERLDSMNFQDPTSMGSGPEVKQPSMLMCQLKTYQLKGLNWLANLYEQGINGILADEMGLGKTVQSISLMAYLAEVHNIWGPFLVIAPASTLHNWQQEISRFVPSFRALPYWGNPKDRKVLRQFWNRKQLYGRDAPFHVVITSYQLVLTDVSYFQRVKWQYMVLDEAQAIKSSSSARWKQLLGFHCRNRLLLTGTPIQNSMQELWALLHFIMPTLFDSHEEFSEWFSKDIESHAENKGTLNEHQLRRLHMILKPFMLRRIKRNVQHELGEKIEVEVYCDLTARQRALYRGLKEKISISELLEKATSLNDMESMDSLMNLVMQFRKVCNHPELFERADVKSPFAFCNFSSTSSLTKEQLLYCPYSSRGVIKYHIPKKLYRNGGILKEPGPSTKIGFTTHYLDNLLNIWQPNAIHESMMSNSAFSFLRFVDTTPHEASYLFKQSLVARWIDHLAKRDQRARRQFYNTNEESFLISETQSPTTSFNIIPGGALDELTHVTDSMLYLTRPFGQCYMPSARAVPVDAICSDISFEREQRDVLFNPTLRAAFFGTPQYIPGHNREQAMELRDVVRRTEGQGIMTVPSSGHGFSLMKVPAMRDLVLDSGKLATLDRLLERLKSEGHRCLIYFQMTRMIDLMEEYISYKQYKYLRLDGSSKISDRRDMVSDWQTRPEIFIFLLSTRAGGLGINLTAADTVIFYDSDWNPTVDQQASAMDRAHRLGQTKQVTVYRLITKNTIEERILQRAKQKDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B9F7</accession>
    <name>A0A163B9F7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_141038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297021.1">
        <property type="nucleotide sequence ID" value="XM_018430511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B9F7"/>
    <dbReference type="GeneID" id="28991417"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141038"/>
    <dbReference type="InParanoid" id="A0A163B9F7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="310" mass="35932" checksum="29DDC68040F6BC1A" modified="2016-07-06" version="1">MVYTRITGFFSPKSIYPLAAPSSSEKEWIFTLWTSTTPPRPILCKMPHSCYMSLKMEPIFRDSIYDISVWGYILKYGSDRCLESRTLGTNTLVLMTVYTELKPKRCMLTAMLLIMRNPMPTIHCVERVPDRKTLTVIVTVKVAVRISKESNPRSVSSTPVMIYVILSAPENKMTPSPSSLLPPALLPLPSLQTPRFTHLPIIKSATKPSALFTLWPVTHQVKKIETSPFRCTNLNCLENMDGSEVMHRLWNRDLAAVLNFRHMLNNLRYDGTIHVRFTRVIRIRRIRRQAEEDLQEGRRFRQRLTRLQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163CWF8</accession>
    <name>A0A163CWF8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_189429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441006">
        <property type="protein sequence ID" value="OAD66100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284140.1">
        <property type="nucleotide sequence ID" value="XM_018439661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163CWF8"/>
    <dbReference type="GeneID" id="29000567"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_189429"/>
    <dbReference type="InParanoid" id="A0A163CWF8"/>
    <dbReference type="OrthoDB" id="2244892at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="796"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="957" mass="109040" checksum="449C596921650E63" modified="2016-07-06" version="1">MDVYSLLNQGNASLDYNDLCRILKTNNSQTTLENITQATFVYPSTLEQSYAFFDVYIQLLLSIESESQKLHKSTIQDSLRTCIMGIIKLHGFVWLICFSAHLSTHTWQRLYTNPDPMILIYLYGLVLASADKHSAELGRWAEALLQFMKSQSPVIMLHMLMSLWSVDELNGHQTDFATVWLNTLEASMQHSEAMQQSLQVIFNVLAKADTSYMKDTVDQQLETSLKRAPFTASELTLVMIWLENKCRQEIAFPHLAQAYFTFQYTNTIKTKKRNKNPLIKNLLEPQPSDPTERAAIVRKGTQSWVGLVGSLLPYEFEMYLKDAVRVYYPTERKTMLDLVLAEWVIRDPFECHRTIILNSLVEQLQSSKYNIRTAPYYAIIQLFSSAEEMGPRTGYEIKTGAKVDLLAFQAGEKDITRGCCSVLEHLTLSNKQYTHTCVEDCIRTASAGIVEWYVGWMAREHTRLATSQNLFGDYLVVTLKQARQRALSSWVVPACLENLTTDSLGLLLGLNDDPDLVGVFVDYFGQASQLGTRRLVDTLLKTKPKAFIDLLLAYLQRHMNDTKMKSEMSRAWFKNHFLASLLTEAAEAVFVPTSTYATTSIMDESQPNVASQLLAQLLTDPDHYEWYFGTPVVPLGTKERNFGSRDVARTHDIISVWHTGLASMLQEMVRIPDNKAVGLVNFWRSLWIDSDTHKFSVPTPWILQCLGLYDLAPASVKQLMEEFLRVGLHSVNTKGRGFTLRMVDLVMLSDMPEADEVFDLFVRLLEEQGNTVQAKEEEAKIVWAITATMVELAEESKLETEQRLHNKPTSKKRQKQPVPTRPKDTHWNKRRGRGGRKNRLDKKAVVVEEVVEETVVEEQEEEDDCLGTLIGRVIGFVLIAVTASDRHSICAETRRRLWQSLASSLLCYEALDTLRQLSLSEELQEDILSITDACLERLKTTQPILWEDARRVLGTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163CWS5</accession>
    <name>A0A163CWS5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_70993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441005">
        <property type="protein sequence ID" value="OAD66170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284210.1">
        <property type="nucleotide sequence ID" value="XM_018442384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163CWS5"/>
    <dbReference type="GeneID" id="29003290"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70993"/>
    <dbReference type="InParanoid" id="A0A163CWS5"/>
    <dbReference type="OrthoDB" id="2261465at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="112" mass="12992" checksum="91B877A1E3405A8F" modified="2016-07-06" version="1">MCESYSLVVLKEPYISIWIIISSEVTWTTHRNLIPQWLIGTVQFYFQHVDFYGFLHFLAFMKVMKEHDAAGHDLSVPIVKQWSQSTHTLGHQTQPTYAVISVNDICHQVSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DC70</accession>
    <name>A0A163DC70_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_115435</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288380.1">
        <property type="nucleotide sequence ID" value="XM_018428462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DC70"/>
    <dbReference type="FunCoup" id="A0A163DC70">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163DC70"/>
    <dbReference type="GeneID" id="28989368"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_115435"/>
    <dbReference type="InParanoid" id="A0A163DC70"/>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01374">
        <property type="entry name" value="Glyoxalase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017782">
        <property type="entry name" value="Hydroxyacylglutathione_Hdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03413">
        <property type="entry name" value="GSH_gloB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="10">
        <location>
            <begin position="11"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD70340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="251" mass="28351" checksum="87791E0BE4E00BC7" modified="2016-07-06" version="1">MKIIPIGVLENNYSYILIDEKTKEAAVIDPVEPIKILNVISQTGAKLSSVFVTHHHWDHSGGNIELVAKKPGLAVYGADARIPEINYVCKDHEEFKLGSLDITPLHTPCHTKGHVCYYVVDTATNERAVFTGDTLFIAGIGNFFEGDARDMYRILFHVITTLPDDTWVYCGHEYTKENLKFALTLEPHNESLLAKWAWCQDKQITVPSTIGQEKLYNPFLRVNEQTLQLVAGKTDPVEVLHTLKEMKNAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DGV2</accession>
    <name>A0A163DGV2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_182140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289180.1">
        <property type="nucleotide sequence ID" value="XM_018438573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DGV2"/>
    <dbReference type="GeneID" id="28999479"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_182140"/>
    <dbReference type="InParanoid" id="A0A163DGV2"/>
    <dbReference type="OrthoDB" id="1742084at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="99" mass="11163" checksum="5514050632FA93F1" modified="2016-07-06" version="1">MYNQNLFPNYAGNHSHGPQGYYSPNQGFSPFVNPNFANQDPIRMQPSQERIPSETASMYQRQEDGPLLWFAGPPVNPTPIQGPAHSLAYLKWKQAQKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DH14</accession>
    <name>A0A163DH14_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavodoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_114694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289220.1">
        <property type="nucleotide sequence ID" value="XM_018428408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DH14"/>
    <dbReference type="STRING" id="763407.A0A163DH14"/>
    <dbReference type="GeneID" id="28989314"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_114694"/>
    <dbReference type="InParanoid" id="A0A163DH14"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF109">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] FLAVOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="9"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD71180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="158" mass="17775" checksum="BF9F7137AB5DAAB9" modified="2016-07-06" version="1">MASVKLPPITFLYGSQTGTSQDYASVLSNQARQFGFKDVTLTDMDKWKVLDSGKYEGPTGVNEDRELVVVCTATYNGMPPDNAERFDKFLDKSDAQGNERLLHGLQYAVFGIGNKNWRTYQYFPIKVDSRLDDLGAERFFLSGKGDTDGDIDSDFNDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DU75</accession>
    <name>A0A163DU75_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Srp40 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_112609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291490.1">
        <property type="nucleotide sequence ID" value="XM_018428299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DU75"/>
    <dbReference type="STRING" id="763407.A0A163DU75"/>
    <dbReference type="GeneID" id="28989205"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_112609"/>
    <dbReference type="InParanoid" id="A0A163DU75"/>
    <dbReference type="OrthoDB" id="5599646at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039191">
        <property type="entry name" value="Nopp140-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007718">
        <property type="entry name" value="Srp40_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216:SF1">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05022">
        <property type="entry name" value="SRP40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Srp40 C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="75" mass="8582" checksum="F4912D2FA6B6C1C6" modified="2016-07-06" version="1" fragment="single">QRVKPEEVEFTDDRLKDNSYVGKGGSDEMSYGWKAHVDLIKTRGDKFRAEKNKKKRGAYRGGAITFESHSIKFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DVJ3</accession>
    <name>A0A163DVJ3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3 8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_186881</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3 8"/>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291720.1">
        <property type="nucleotide sequence ID" value="XM_018439296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DVJ3"/>
    <dbReference type="STRING" id="763407.A0A163DVJ3"/>
    <dbReference type="GeneID" id="29000202"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_186881"/>
    <dbReference type="InParanoid" id="A0A163DVJ3"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="10">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="377"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="8">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD73680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="534" mass="62036" checksum="A771B22F2B955D9C" modified="2016-07-06" version="1">MINKYGVNDIVVQEVFDIDSNIFTAKSPEEQQNVHGFIFAWPYQEEPLPNNHSTHDSDSEEVFYSCQVITNACATLALLGVLLNCDKEVDIGETLTMFKNFTKGFDPVNTGLAIGSHPLLRDTHNSFACEEDKEAAIASARGISKENDYEENGDYINEDIFHFVSYIYKNGYIWELDGLKRAPVKLVKCTLSNWNETVKPILQERMRSTGESQISYNLMAVISDPLKALRESITDLNDLVEAYDHEISEQESRSQDLRSKVLGKRSRLVEDYRIEIKRNMLGFLRNRQENHKEKRRNLEKDLEMGEAEKEKEEANNLRLDHDYGPFLRALFQKMEEKELLYLKEPVNVKNVNRHLNYFNGVEFHEFLFGEEDQKLKTMKKKQKVNKKGRKKQKKTSDNDAKPYLPSETTILLMRIAHYLIYNSHHIFAEMSLPEHCALKINSLVFSFSLTSNVDSRILLTATHDRKQEFLGLDLSKLFERRGLLYFAGKHFGLGYRMEIIRRPSKHKDPREHIYTLNESNISVITFTDLQNIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163E6P1</accession>
    <name>A0A163E6P1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_180279</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295040.1">
        <property type="nucleotide sequence ID" value="XM_018438290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163E6P1"/>
    <dbReference type="FunCoup" id="A0A163E6P1">
        <property type="interactions" value="1007"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163E6P1"/>
    <dbReference type="GeneID" id="28999196"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_180279"/>
    <dbReference type="InParanoid" id="A0A163E6P1"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03335">
        <property type="entry name" value="TCP1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000009">
        <property type="entry name" value="T-complex protein 1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000070">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02340">
        <property type="entry name" value="chap_CCT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD77000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="555" mass="59737" checksum="83F5FEBCDD0D7A4B" modified="2016-07-06" version="1">MFQRDQNSSLFLGGERTTGQDVRASNVLAAASIANIVKSSLGPVGLDKMMVDEIGDVTISNDGATILQLLEIEHPAGKVLLELAQQQDREVGDGTTSVVIIAAELLKRANELVKNKIHPTTIITGYRLASKEACKFIAGEMSVKVDTLGRECLINAAKTSMSSKIIGSDSDFFAELAVNAITAVKSSNGRGETKYPVKAVNILKAHGKSGRESVFVRGYALNCTVASQAMKTRITNAKIAVLDMNLQKARMHLGVNIVVDDPDKLEDIRKREIGITTERIQKILATGANVILTTKGIDDMCLKLFVEAGAMAVRRCKKEDLKRIAKATGATFISSLANLDGEETFEASYLGEAEEVVQDRISDDECLLIKGTKIQNSASIILRGANDYMLDEMERSLHDSLCVVKRTLESNSVVPGGGAVESALSIHLEDFATSMSSREQLAVAEFANALLVIPKTLAVNAAKDSTELVSKLRAYHNTALGQGADPSKRALKYYGLELINGEVRDNLKAGVLEPAMSKIKSLKSATEAAIAILRIDDFIKVAPEQRGNPDDGHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167J5V0</accession>
    <name>A0A167J5V0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_175406</name>
        <name evidence="2" type="ORF">PHYBLDRAFT_176345</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441012">
        <property type="protein sequence ID" value="OAD65227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV441004">
        <property type="protein sequence ID" value="OAD66349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283267.1">
        <property type="nucleotide sequence ID" value="XM_018437742.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284389.1">
        <property type="nucleotide sequence ID" value="XM_018437481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167J5V0"/>
    <dbReference type="GeneID" id="28998387"/>
    <dbReference type="GeneID" id="28998648"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175406"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176345"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD66349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="148" mass="17641" checksum="55B3EFD8ED739D97" modified="2016-07-06" version="1">MPDKMINVLSFNTTQMETENITFPLQDKNELLERKIIKKLIELHKVQKLKWWYLALYILKAISLLKIFRKSESKAKCVTIFVCRACYNFKQWKFVNILLGKILSLRTRRRDKISRTIFSSLTSEMISVTIPLFLGGQIRVFRKSFKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JCA0</accession>
    <name>A0A167JCA0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-phosphofructo-2-kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_26233</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441008">
        <property type="protein sequence ID" value="OAD65698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283738.1">
        <property type="nucleotide sequence ID" value="XM_018439886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JCA0"/>
    <dbReference type="FunCoup" id="A0A167JCA0">
        <property type="interactions" value="391"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167JCA0"/>
    <dbReference type="GeneID" id="29000792"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_26233"/>
    <dbReference type="InParanoid" id="A0A167JCA0"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000644">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF32">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007888763" description="6-phosphofructo-2-kinase domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="4">
        <location>
            <begin position="7"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD65698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="476" mass="55801" checksum="483734FDA2EA057E" modified="2016-07-06" version="1">MHALNIIIIIITVGLPARGKSYIVKKLRRYLNWLQYETRVFNVGNLRRVNEASQQHDQSANFFDPDNTDMKRIRDDLAIQVLDQMIDWLKQGGRVGVHDATNSTVERRKLLIDRLRKEPEIKVLILESVCTDKMVLERNFRLKLFGPDYKDRDPAEALLDFKSRVDNYERAYESVGDWEEEQDIQFCKLINVGKKVIAHNISGYLSGQCIFYLMNFNLAERQIFITRHGESMDNVTGRIGGDAPLSEKGRKYARALERFVSQQRASFAYDLASRKVKEEDDWRSYGLEPLDGKKESETIDTRTTQEKIDAKAKELSSGQFTVWTSMLKRSMATAANFDPDVYDIKHIRFLNEINSGMREGMSYEEIQRFYPEEFHTRQSNKLYYRYPGMGGESYIDVIHRLQSMIIELERMTQSCLIVTHRVVMRIILGYMLDWSQKEMPHMLVPIHTVYELRPKPYGTELKKWQYIESVDSFVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JCU6</accession>
    <name>A0A167JCU6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_175911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441008">
        <property type="protein sequence ID" value="OAD65738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283778.1">
        <property type="nucleotide sequence ID" value="XM_018437603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JCU6"/>
    <dbReference type="GeneID" id="28998509"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175911"/>
    <dbReference type="InParanoid" id="A0A167JCU6"/>
    <dbReference type="OrthoDB" id="2245207at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="2">
        <location>
            <begin position="202"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD65738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="457" mass="52132" checksum="5C809DEF5782E279" modified="2016-07-06" version="1">MSDQTSPPSPSSSNSYAHNAHNADNSYNTTTLKDQAVVDPSDTNANSDQIDVIAIATELDTSRKNASTELLKVLENPYSSPDELNEAQKLVDSTKARWVAFLAAKKTLDDMNGETALQMLTAKKNTDDYRSNPDSFVPPNLPVLQLKGGSIRQPDKKIYDSIRSFLNDFEVQLIAHSLPLDKNWERLFRLTCDDMQRLSFERTNAGKGLTWKEIREKLELEYGYPQYVWAKRFALKSITQRHDESVKEFSERYRGAAHAADLHNEDELVWLFISSLVKPVRDIALQAIVRQFGLKMPHDMKEVIQLIINSVEGESANLFLNKYTTSSKRRQHEEHRPTGSSKKYRGDPRSTRGNSNSKDMRQTHPKGRHMREGFVQMQNLMDKDNIFLSNVAKQPSLCRHCRKVPFFPGHHCPEFPQHKPRSNLTLINPNPNPNPNPSPNPKPNNETTENTVNSRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JJ47</accession>
    <name>A0A167JJ47_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nickel/cobalt efflux system</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_128739</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NiCoT transporter (TC 2.A.52) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441006">
        <property type="protein sequence ID" value="OAD66087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284127.1">
        <property type="nucleotide sequence ID" value="XM_018429237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JJ47"/>
    <dbReference type="STRING" id="763407.A0A167JJ47"/>
    <dbReference type="GeneID" id="28990143"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_128739"/>
    <dbReference type="InParanoid" id="A0A167JJ47"/>
    <dbReference type="OrthoDB" id="5197598at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015099">
        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004688">
        <property type="entry name" value="Ni/Co_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011541">
        <property type="entry name" value="Ni/Co_transpt_high_affinity"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00802">
        <property type="entry name" value="nico"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611:SF0">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03824">
        <property type="entry name" value="NicO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD66087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="449" mass="49398" checksum="B4A99DF021DED414" modified="2016-07-06" version="1">MSHVPGKIGRFALRFCSEQSFVYRLLFGPDPHKVRPKVLVMITFLLSVNVAVWVVAAIVYNPYPSMLGTGALAYTLGLRHAVDADHISAIDNVTRKLLNDNQHPVSVGLFFSLGHSTIVFITAIIVAATANAAANGLENFSEIGGVIGTSVSIVFLTLIATLNIIVLVGVVKTLRRVKREGVYTELDIEEYMNNRGILGRFFRPVFKFINASWKMYPLGLLFGIGFDTSTEITLLGITAVQGASGMNMWLIILLPLLFTSGMALIDSLDGMLMLFTYTWAYVNPIRKMYYNLIITSISVVVACLVALIEFFALIGEQLELENGWWEFWYTLADSFEWIGIVIVGAFIVTWLVSAIVYRVMGYKDLEREFDNHKPQQGEKGAVGVVIVEGGTSGAAGKSEVDLEEGMAGMETKDETSKSTEPFGGQDSEIINAIPEIEPKRNSLEKNPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JLD1</accession>
    <name>A0A167JLD1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_152563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441004">
        <property type="protein sequence ID" value="OAD66239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284279.1">
        <property type="nucleotide sequence ID" value="XM_018432949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JLD1"/>
    <dbReference type="GeneID" id="28993855"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152563"/>
    <dbReference type="InParanoid" id="A0A167JLD1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="366" mass="41323" checksum="8C4ABEE051FC1DA0" modified="2016-07-06" version="1">MREFVEDIHKKVYVNAILRGPGQVSFCQFIFKLMSIPMSAPMSISVPTICQHTFRLQSFINYYKNPDLVIKGNEPLPPSVFPLLTAASTPMSNIHYIHLLGYYKTAHRNHALVHYEEASSSPYFVYNLINRLKSVNILGQTYEGHNESGYNESGHHGSFIQANFYRSAGEHILAYTGQIQYLFTHSFTPPPTNKNNRQFLFMHYDQHVFAFIKLLIPADNHSRSLEDVDICYPTFSHDSHQSISTVHRILLQVATSEHTARQNSSSLKAPWEESPSVHSGLLKQRLCQKSSLTSGARRSTSQDHGVFNIGGTTPRMVALSTDQRRPFQAGLLAKIKGALRSSRPYSLTFHQTHPQTSHKTIGGLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JVF5</accession>
    <name>A0A167JVF5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_174798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441000">
        <property type="protein sequence ID" value="OAD66768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284808.1">
        <property type="nucleotide sequence ID" value="XM_018437341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JVF5"/>
    <dbReference type="GeneID" id="28998247"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174798"/>
    <dbReference type="InParanoid" id="A0A167JVF5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="170" mass="19201" checksum="8D58F0A7F012CEA2" modified="2016-07-06" version="1">MSTIPELYSKKCHCAGCSQNNLSYSFVARRTAQRHNKRARLNAIRCERDMFTQRNMMEVNDEHKQPRALEELYTQKNSPVLEGASMSDTEDVSFTNDAISNDNNGDSGSNSNEISEDESEDNVIGLDNNELNSKDPFATPDMPQNLVHRFIATFVVMFAPRYLVDKGTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K5Q7</accession>
    <name>A0A167K5Q7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptide transporter PTR2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_136953</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285370.1">
        <property type="nucleotide sequence ID" value="XM_018429821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K5Q7"/>
    <dbReference type="FunCoup" id="A0A167K5Q7">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167K5Q7"/>
    <dbReference type="GeneID" id="28990727"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_136953"/>
    <dbReference type="InParanoid" id="A0A167K5Q7"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD67330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="62621" checksum="B1801911E506EB74" modified="2016-07-06" version="1">MEEKTAQTESIDDVYHDNHEHPAPTEEDWKELPEVSDIIPKSAYLVILVEFCERFTYYGLSGPFQNYIQYPQPESYPADQPGAMGKGQQTATALTTFFQFWCYITPIFGAIVADQYWGKYKTILVFACIYMAGLIILTLTSIPPALDNNSSFPGYVVAIIIIGLGTGGIKSNVSPLVAEQYRSRSPFVKTLKNGRRVIVTPQATYQKIFNMFYWGINIGSLSAIATTELEKNVGFWPAFLLPTLMFIPCIIVVLLGRNKYVQNPPRGSVFIEAGKLFILNWKVKGGLAACKPSALALTHPELAAKVTWDDVFVDELKRTLKACIVFCWFPIYWLCYSQMTNNLVSQASTMLTGNVPNDIMQNIDPIALIILIPLMDTFIYPFLRRVGIPMRPIMRITCGFFFAAVAMGYTAGIQSKIYKTAPYYDHPEGQNWISAAYQIPSYVLVAISEIFAAITGLEYAYKKAPQSMKSIVMALFLLTNCFASILAFALVSVAVDPKLTWMYTGISGACAVATILFYICHRKNDDDDVEQDAIGRSDEELNGNLSPKTVAPVEYEAEKAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K6D2</accession>
    <name>A0A167K6D2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_97692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285406.1">
        <property type="nucleotide sequence ID" value="XM_018444029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K6D2"/>
    <dbReference type="FunCoup" id="A0A167K6D2">
        <property type="interactions" value="459"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167K6D2"/>
    <dbReference type="GeneID" id="29004934"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_97692"/>
    <dbReference type="InParanoid" id="A0A167K6D2"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="3"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="2">
        <location>
            <begin position="154"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD67366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="55220" checksum="9E471BCF2383AEB0" modified="2016-07-06" version="1" fragment="single">PSLDNIPTEIVIQILKNLTHHKDIMNCALAIRSWSYCCYEIIWFKPNMIRPTVWANLCSTLSQSTPTYYPYHSFIRRINLSALADCVKDNHLSCLSVCDRLERITLTGCHKLTDAGLCGFLSKSSSAYLVSMDLSEITNITDTTILKIAECCPRLQGLNLSMFKDGQEQFHGVTDESIIKLAEGCRGLRRVILNNCSLLTDASITLLAKNCRSLLEIDLINCAITEDSLQAIFKHCRELREFRLNQCVNLGDSGFLDSDLAPSVFRECPYYDQLRIIDLTGVSKITDDSVIRIVEAAPKIRNFVLNKCHNITDKAVFAICNLGRYLHVLHLGHCLNLTNRSIIQLARSCTRIRYLDLACCTQLTDAAVFELANLQRLKRIGLVKCSKITDESVKALASHARIANSLERVHLSYCSRLTISSIHCLLNACQLLTHLSLTQVRDFLRADFQHFCRKAPSDFSEQQRQAFCVFSGKGVQNFRNYLNANEGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KD14</accession>
    <name>A0A167KD14_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_68169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285836.1">
        <property type="nucleotide sequence ID" value="XM_018441900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KD14"/>
    <dbReference type="GeneID" id="29002806"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_68169"/>
    <dbReference type="InParanoid" id="A0A167KD14"/>
    <dbReference type="OrthoDB" id="2240884at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="212" mass="24576" checksum="3EF0C5A3EF33BAC4" modified="2016-07-06" version="1">MKSVRLALINRQFDDQYTFELKGYLSLQQFCSALCLFNQATRQKPPPGNKLIWLGSLLTAWLFITVAIYSVWQQAKHPSVLLIIPLLIVLTSLVTLWRYRFKRLQFEHTILEICSRLNATENIRGINYRFSKNGLDLVSPTRTSFLCFKPVYAIIIEFDNRYTALTSQQFNDPSEDTFYPSYLGSPAPVHVVNTEKHPSMFYDSPHPLKSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KLZ3</accession>
    <name>A0A167KLZ3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Complex 1 LYR protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_188731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286439.1">
        <property type="nucleotide sequence ID" value="XM_018439553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KLZ3"/>
    <dbReference type="FunCoup" id="A0A167KLZ3">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167KLZ3"/>
    <dbReference type="GeneID" id="29000459"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_188731"/>
    <dbReference type="InParanoid" id="A0A167KLZ3"/>
    <dbReference type="OrthoDB" id="15893at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35763">
        <property type="entry name" value="COMPLEX 1 LYR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35763:SF1">
        <property type="entry name" value="OS11G0133900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14215" checksum="7FB711E8A90C92C4" modified="2016-07-06" version="1">MSQVLNSYRHLLREVNIQYTKGANNDTFAKELKSIFRQNKDVTDPKKVSALVQNADNVLIFLKSSRQHKILRDQYAAIVLEQKKRIEMSAHRVGLELPKPYDPNSPLPGSNPEAAVADRVAKAFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KP17</accession>
    <name>A0A167KP17_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_172971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286585.1">
        <property type="nucleotide sequence ID" value="XM_018436910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KP17"/>
    <dbReference type="GeneID" id="28997816"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172971"/>
    <dbReference type="InParanoid" id="A0A167KP17"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="149" mass="16930" checksum="198BCB1995DB45F8" modified="2016-07-06" version="1">MPNTIFNLSNVHNVLVNSPTKEIKMLPLDVVVKNISRKLCARELKYGETKKHHRAELYISDRNVRLAQKDTKLCYCKATIFIKPYDNSPEVVLICTTNDYTNHVSGDASEIKTLPLSSEAIKIIEDQLKGGSICRNTRISVLKQIEEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KQ18</accession>
    <name>A0A167KQ18_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_173038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286657.1">
        <property type="nucleotide sequence ID" value="XM_018436928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KQ18"/>
    <dbReference type="GeneID" id="28997834"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_173038"/>
    <dbReference type="InParanoid" id="A0A167KQ18"/>
    <dbReference type="OrthoDB" id="2271013at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007889514" evidence="2">
        <location>
            <begin position="24"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD68617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="210" mass="23701" checksum="248BEB03546A9DDD" modified="2016-07-06" version="1">MMSLFITMATYGLFLVSVPLVASSTCIRTCLIPKILYKVPIYHLTANSTVICVGFATAYIYCILGFIIDLFESTCSFSPFGSPRVNASRTLGPVGFTTRLSLAQKELTRLFPGYAICSLLIWANTNQYDTLRDGFLFLQTIFLILLPWGLSCQSQAIQKSFQIAFRCCLFWGLLYAVMPRDTNYHIVELTRLLKHYRAVSHRSLGDAYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KXV1</accession>
    <name>A0A167KXV1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_188358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287169.1">
        <property type="nucleotide sequence ID" value="XM_018439489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KXV1"/>
    <dbReference type="STRING" id="763407.A0A167KXV1"/>
    <dbReference type="GeneID" id="29000395"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_188358"/>
    <dbReference type="InParanoid" id="A0A167KXV1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016712">
        <property type="entry name" value="Rbsml_bS1m-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11709">
        <property type="entry name" value="Mit_ribos_Mrp51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="311" mass="35335" checksum="401AC9A03E3A9C26" modified="2016-07-06" version="1">MEKSFAGLLRNSRLATYDRRLAQVYTTPKKCKQIGDWGLKRNLPTVIRTPYVTIGDLDTAEHQTPWQSGQSQVLFVKRWKENFPNSTKPAPRREEPEHNVALMSSSEFKRFLKKVSKNKDDFKEKLDRKEVVPEQLYEFFNVTFNETPSSTTVGPTYSDYEHGWDYPVEGRILNADKQGHVVGIAGVTALLTKRNSIGLRPNSERRIRTFYVEKAGFDEQGKPMVIVNINHSSSSAIPSLLSPDGFARYNEGRGSSLFGSMAADDMFSTKPHEQARTQDDDSKVSANPQHTQLMRRIYGLLEPVESADKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KZ91</accession>
    <name>A0A167KZ91_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 21">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="8 21">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PHYBLDRAFT_188388</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines. Negatively regulates the biosynthesis of acetyl-CoA from pyruvate in the mitochondrion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 21">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7 22">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 21">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="8 21"/>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287256.1">
        <property type="nucleotide sequence ID" value="XM_018439492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KZ91"/>
    <dbReference type="FunCoup" id="A0A167KZ91">
        <property type="interactions" value="587"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167KZ91"/>
    <dbReference type="GeneID" id="29000398"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_188388"/>
    <dbReference type="InParanoid" id="A0A167KZ91"/>
    <dbReference type="OrthoDB" id="275353at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000003">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000019">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF0">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="13 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 21" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="63"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="372"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OAD69216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="416" mass="44678" checksum="430558CD08A7830C" modified="2016-07-06" version="1">MSLSNKLSIRDIDLKGKRVLIRVDFNVPIKDGKITNSNRIIQALPTVKYALEQGASAVILMSHLGRPNGEVVAKYSLKPVAEEVSKLLGKPVEFLEDCVGPETEKACKEATGGQVLLLENLRFHIEEEGSAKDAEGKKVKADAQKVKEFRDSLSRLADVYVNDAFGTAHRAHSSMVGVELPERAAGFLMQKELEYFAKILEHPERPFLAILGGAKVSDKIKLIENILDKVDSLIICGGMSFTFKKTLDDVKIGNSLFDESGAGLVHDLVEKAKAKNVKLVFPVDYITADKFSPDAETGYSTDADGIPEGWMGLDCGKESNAIFREEILKAKTILWNGPSGVFEFEKFATGTKSALDAVIEATKNGAVTVVGGGDTATAALNWGAGDKISHISTGGGASLELLEGKELPGVAALSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LVY8</accession>
    <name>A0A167LVY8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_170575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="126" mass="14655" checksum="E08B0A17A26AA8EE" modified="2016-07-06" version="1">MVPIHDNIIKVKSTNSVEFTNPYTQFIRQMQYENNRKLCRLKIDIRIVVTLAGIDIYTGAVKLLVNTKYIVNGLLNCIHDITDAREIFGAYIQVIFLVDEDKNIETNDFGDKHPIANHDDYLFIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LX81</accession>
    <name>A0A167LX81_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Galactose oxidase</fullName>
        </recommendedName>
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    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_66447</name>
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    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018441642.1"/>
    </dbReference>
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    <dbReference type="STRING" id="763407.A0A167LX81"/>
    <dbReference type="GeneID" id="29002548"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_66447"/>
    <dbReference type="InParanoid" id="A0A167LX81"/>
    <dbReference type="OrthoDB" id="5594682at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007890079" description="Galactose oxidase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="704"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="851"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD71276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="877" mass="98644" checksum="68E1AF584C50343F" modified="2016-07-06" version="1">MNYLIWGVFLAGLTLLSLIEASYDLPLEFAGSIKRRSGAATLVHDNVVYTYGGEIYDHPYSNLFTSVSLSDSGDIIYQNVSQQTPGPMCTVSNIILLPDNETIILFIGRYVEYKFPDTFQIYTYNLNDPLASWTKLEPPTGAVWPPARKDYSVTLAPNNKIYIYGGADMNTSAILNEMYSFDPNTNLFTNLTQPDLIYVNSHTAIALPNGTIVYATGRIGRLATEGLIQVPPDQVLLYDTNTDTWETVHTGGASFLARTNAGALLDPTQRYIFLFGGLYTDDVYQELLNDFYVLDTMTWTWIEPNITGFPPGPRNQASMAFVADDLLMIFFGQAMTISRNDFNILRFNTDNSIYSWLKDSDELVYPNRKKDKKGSILSTSAIVGISLAGVCVVLMIFCAFKFWSQVKTWPLLVYNGIIWSPRFGEPTWTEGFRLSSRCISLGLLAFYFAYAIREISDSTKATVVLKSSSSTIQSPDIRFCFDGWNNSAGAKSSDRPHLLCSTDEGYDCVDFVTGLDMSVHQPAFSDRIGDVSCFLFAPPKRFNLVEDAGQQGLGTTLIFALYGDPGVNGAIHTTIYPPGMDPNVGIYGVKTTDVGQKMSDKQVNDWIVADLDDRYAINVHSVYPKTVSTLSYQIQDHQYLVDNKWNKIGFLQDYDHIPEISTIYRPGVVSDSIKARGKYHVSTLRVFPNEYVTMISQEKAMSTVLNMIGSLGGVISLMAAVQLVLFGFRPTSPWGIVQRFAFGSFKTSIDRSLRNEFNYPYKSIPLVHRISNLHTSPSSETVVSLNRQDVNSQLLENDTVPETNSERRFHQIEERMQLMEKLLQAYYVDNEIFKELDKAIRRDEPRGRSIDEMIPDYEAQTGTRNRSHQRRLSESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MCA4</accession>
    <name>A0A167MCA4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_146639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290487.1">
        <property type="nucleotide sequence ID" value="XM_018431698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MCA4"/>
    <dbReference type="GeneID" id="28992604"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146639"/>
    <dbReference type="InParanoid" id="A0A167MCA4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="703"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="537"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD72447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="740" mass="79358" checksum="99A6700A9857222D" modified="2016-07-06" version="1">MNSKVYNALCAAFALAYLLAPALLFIPVMLWEASPMPSAFCMAKSAKRRRPSMAGVGATPFVAVRPDGEDQIEAHKNVMPQTILGMLSNWVGSLWSTGSQTTGEPSGSLLSKRHGGIPGHMSVNDSSSEAEDVVCVGKSSVFFGAGLRGYVPHLLPLHKLGRGIATMVFPVNGVAGTCGETHADLDEGVSSELVDECDEAEVSVRLRFICDRFFSEGFAKPRLSARFLDAMLEEELNDSANKAHRDSLTEVAEPKCGLVPKSAEETPVQRQESIQTPSGLDNAGFVVPKPKFRTVEGLNEAFALSSWQSANGFFGECLSTGLPTPMEIDDDLAWSEAEEVEDPMEIDDVAEVMVLDADCGEKLMAHTYNPTVTDLQYVSQSANMDCDTNDLPACVPQQAADDKMEDDTEKIVLPEPSSLKKYDAPKPRQKVGADEVKGSKEPSMAVPRPKEKSSKLPRPASQKAIEEAKTAIEGPESKMASASCDLPSQLPKPLFGLRTERAKLVSSLASEVPEPVTTASCDKGKAPKKKAKTQGSTATPAAQVSVPVAAPSSKKEESIKEFKSDLPSASRGKKVKTSGGDEKADLIIEPIGKEIGEPQIQPFPARNPASKPAKSSSNRGKEDPKSLLKYVLRFKGDPAVNKEGVVKESAKLMIPKTWTNFCCPVRFTKRTSCLSVGPGAKPTRSERKVDPETSGKLYGDTGIPGPFTVLFFGIICVVIRVGSLGLDYRFPLGLTPCSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MDJ6</accession>
    <name>A0A167MDJ6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T4 RNA ligase 1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_78069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290579.1">
        <property type="nucleotide sequence ID" value="XM_018443328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MDJ6"/>
    <dbReference type="STRING" id="763407.A0A167MDJ6"/>
    <dbReference type="GeneID" id="29004233"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_78069"/>
    <dbReference type="InParanoid" id="A0A167MDJ6"/>
    <dbReference type="OrthoDB" id="276239at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019039">
        <property type="entry name" value="T4-Rnl1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004:SF1">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09511">
        <property type="entry name" value="RNA_lig_T4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T4 RNA ligase 1-like N-terminal" evidence="1">
        <location>
            <begin position="71"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="370" mass="43057" checksum="6C09EA2B67C75F2E" modified="2016-07-06" version="1">MVNSTIELPDSSSTIQFEKDHDVIERLCAHLAAKPKELRNRPFTLQNDTWTSWTVRESVYKRNQGSFPIMARGLFTLKRDERHCIVARGYDKFFNVNETKYTQWTALEKETQGPYEITTKENGCIIFIAALSSQTVIVTSKHSIPEPKDNPQSHGGVGYRWLQKHLQSAQASEEDLASWLWSNSITLVAELCDDDFEEHILEYPPHKRGLYLHGANYNTAQLHTLPSQLVHQIATTFGLWPVSFTTLDTIAQVKELASKVQLTGKMDGREVEGIVVRCQRQDQDFLFKVKSEPYLVFRDYREVTKSVLENPDAAPKYTYPKAYYYWRWIQHRLKDHPEWFEKYTLSKGIIDVRQKFEAYWEKGDLTLPDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MHD2</accession>
    <name>A0A167MHD2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GBD/FH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_65225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin homology family. BNI1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290889.1">
        <property type="nucleotide sequence ID" value="XM_018441420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MHD2"/>
    <dbReference type="STRING" id="763407.A0A167MHD2"/>
    <dbReference type="GeneID" id="29002326"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65225"/>
    <dbReference type="InParanoid" id="A0A167MHD2"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="4">
        <location>
            <begin position="140"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="100"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="666"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="716"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="617"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="753"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="801"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD72849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="814" mass="91105" checksum="D8F8B5912093A930" modified="2016-07-06" version="1" fragment="single">MDTLPNTGGKHRLKSTTRGRLHSKRSIPHLSRTKLASTPASPTTPTLSEKQSIDPKPAQQASHTLSTASFIRHNQELSSNLQSLGRSKAALPRNGVQLTLPHWKDQETSSSSCSVDSRLQARTTSLGSTPKIKEKPTEDPHRPSDQEIERRFRLASKDYLHTNLVDISNLSNDRKWWLLCNQKEFTKLFSNTTKKRQNGLTRARSRTNLKDTAPKVLTPQAFLRPFLADNRSGITLRLVKDLEAQLRTSSLGWIRQFIEENGMRIIIKELGMINNNPAREQKNYLIELGIIKCLRPMFNHIIGIQEALSDPFCSIHLILSLLSPYIPARTAACDALTFLCYCDVPTGHSMVLRGMDHLTECSHEYGRFDSWLKALDSTLENRGKMGSLVGANKDLWQTEVIGTPSSPEAHLMEYALSNMLLVNAILDPDTVEGFDSRMAFRNQLHQSGLSQILVKMNSLNYEKLNEKIFQFKDLEDFDSASLYGGLVVGSVIDPADVLDKVLATIRGTHAYESLQNTLHHLLLIQCDPEKRNRYYQLIDSIVCEIVLDHKNSPQEFLDDYTSSVHDMIARYTKGSPPDETTEENNTSLNKSIEREKELQRQINLGAGGLVGQLNCKIDSLEEALKASNLANIALKQRLSDLEIEFQNTLEATDAQIKRLYDTVREQTEYGSPTDKRRRVRGVRKPKIDGDTRPLSISSILLDESLHAEALTESPIEVTSPLPPTQSQSQPHPHPQPNPSSGNGKPSLRVSIGSRMSNLVRRSTQPEISPVPKKPTSPKINDTPIIEGSLPPQAKLRYSEDQLPTPSATKSTSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MM33</accession>
    <name>A0A167MM33_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_145649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291286.1">
        <property type="nucleotide sequence ID" value="XM_018431505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MM33"/>
    <dbReference type="GeneID" id="28992411"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145649"/>
    <dbReference type="InParanoid" id="A0A167MM33"/>
    <dbReference type="OrthoDB" id="2253782at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31639">
        <property type="entry name" value="F-BOX PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31639:SF256">
        <property type="entry name" value="OS07G0242900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="563" mass="65910" checksum="D43C88343EA508E3" modified="2016-07-06" version="1">MELSELPFEILLQIADSLSTRDRLSCALTCMGWRYLFQSALWTSIRTNDFCNIKILIDIIKGSKNTFVSYGLWVYSLRIGHYYVESRASETQFSELFKCLPNLKHLDLDERSHIYFDTDTARSNKKLNSLKSLKIGYTTNKYIQPTKNVLKTINVCSMLQRLEIHRFRRGFRMDFSVDDFDNMHQKLQNLSSFGAEIYFNPDFPATLDKIPSTAPAFAITSVDINSKLYDSVIGQETTNDNNWNPLWLYYFGYKYPNLRSLKLHATDMRENIKYSNKRQTMISIFQSNPNAFRHLEAFSLTTDCFFEFTDLILWELFCASKVSLKHLAIDIAYGSYNYYSYPIDLNRIFQTFSETLESFSFTGWLKQQERNLCQHGLQSLTLQRCSVPAEIFNYLSFKCKSLDHMTLNTISTLEIGHLQYNISNQTINTTTCSVLTLLSQLYDAPSLNEKNKKQKTGMDSKYPIVARHNLKWFYKYWPLECYVDYNMGALKLSKEGTDTALEYYQKFHLNKASKVLKDNRFYYGHVPLVKRKCELNRGYAELRFGKIETPPVICPTKYYFSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N2M8</accession>
    <name>A0A167N2M8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_61130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292859.1">
        <property type="nucleotide sequence ID" value="XM_018440755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N2M8"/>
    <dbReference type="STRING" id="763407.A0A167N2M8"/>
    <dbReference type="GeneID" id="29001661"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61130"/>
    <dbReference type="InParanoid" id="A0A167N2M8"/>
    <dbReference type="OrthoDB" id="2404451at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="780" mass="88038" checksum="A36ADAD5099F5253" modified="2016-07-06" version="1">MTEIGQSIPDDIDMYHDKNDTKYTMESMELDNTISYKCTCNFEDSEGEAHIYDSSQISTNTFTKAELMSIHLSQLMLQHRIAKAAYRDLVRFINTVIRDHNDIMIEPGAKISHGKTVDTLLKSKSSVKGHEYDVCSSGCQLYGINDNQESCVDCGKPRYKTDPNQSQTPAASMKLLSVGNMLSQMLADPATRELLCYRANQESVAGQLTNILDGDNYKQLVQQGLFSNPNVIAIRLYTDRPIHQPTHLDSFLIPIINELRDLEAHGLVVKHNGVEFCRSKVYLMLASGNIPAVADMAHIGSHTSLFSYCFCETKGKCPTNRRHGMYFDDISARLRPFGDFKVGNPPSIYIQLSTFSGSSFFALDELHLITRGIGKLVYDLITVTLTKETKFYYTHPDNTLNTTEYPFHIPRADLVTIGNCITSSRKYIPTSFQGSFDNVFAKIDGIRAVDWLDFLLYLVPTLVVPYLSNRAVKTALLSLTLTSELLDEMESYFKHWHSFLYQQVQNNTLSHSVFRPVQHYLVHIPYIIKQQGPLRCYSTRSIERVIGVFSKLIKSKSKGGQNASFLVKQFAIHNYTSTAISICDEVNLIRPKPYGRESYMDLPNDPSGAQLWELFHQLVNLNDDSVEGVGSPSVKEALSKYYQRTTGLTGHEFGDSVVVVATHLNRNVIVHSWLVGTVQFYFQHVDFHGFPHFLAFVEVMKEHDAADHDSSVPIVKQWSQSTCTLGHQTQPTYAVISVNVICHQVGLVQYPPNGNQFYVIAPYYIFNNNMCITKGNLSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NB87</accession>
    <name>A0A167NB87_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_110884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293610.1">
        <property type="nucleotide sequence ID" value="XM_018428184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NB87"/>
    <dbReference type="GeneID" id="28989090"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_110884"/>
    <dbReference type="InParanoid" id="A0A167NB87"/>
    <dbReference type="OrthoDB" id="10265996at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="56" mass="6129" checksum="6399C15D3565746D" modified="2016-07-06" version="1" fragment="single">VCLSVCLFICLSVCLFVCLSVCLFVCLSVCLFVCLSVCQFVCLSICLLSIYLFSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NGV2</accession>
    <name>A0A167NGV2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-methylacyl-CoA racemase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_132050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293920.1">
        <property type="nucleotide sequence ID" value="XM_018429461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NGV2"/>
    <dbReference type="STRING" id="763407.A0A167NGV2"/>
    <dbReference type="GeneID" id="28990367"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_132050"/>
    <dbReference type="InParanoid" id="A0A167NGV2"/>
    <dbReference type="OrthoDB" id="16747at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008111">
        <property type="term" value="F:alpha-methylacyl-CoA racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008206">
        <property type="term" value="P:bile acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF5">
        <property type="entry name" value="ALPHA-METHYLACYL-COA RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="42514" checksum="FFB770408059DEFE" modified="2016-07-06" version="1">MVLPLSKLVVLEIAGLAPAPYAGMILADFGADVIRIDRTQGSNTDVLTRNKRSIALDLKNPLSIETIKRLVSKADVILDPFRPGVMEKLGLGPDVLLTVNEKLIYARLSGFGQTGPIALKAGHDLNYLAISGALEMMGRHKEVPHFPLNILADFAGGGMMCVMGIMIALFERVSSGKGQVIDANLTSGTSYLATFPMLMRQHKLLWEGERGTNTLDSGAHFYEVYRTKDDRFMAVACLEPQFYAQFLIGLNLSKEILPDQLDNAQWPAMKKRISGIFMTKTQSEWTRIFDDLDACTTPVLSMEDSVPGGDTPKTGQRWPRKAVFPQPAPLLSRTPGIHVADPTGDPFLTVGKHSVEILSQFEFDKTVIQRLLNEGAMVDVGFRHKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NK50</accession>
    <name>A0A167NK50_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_177191</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294160.1">
        <property type="nucleotide sequence ID" value="XM_018437861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NK50"/>
    <dbReference type="FunCoup" id="A0A167NK50">
        <property type="interactions" value="434"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167NK50"/>
    <dbReference type="GeneID" id="28998767"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_177191"/>
    <dbReference type="InParanoid" id="A0A167NK50"/>
    <dbReference type="OrthoDB" id="1068353at2759"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.50">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018166">
        <property type="entry name" value="S-AdoMet_deCO2ase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01336">
        <property type="entry name" value="ADOMETDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0745">Spermidine biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="41"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD76120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="458" mass="51235" checksum="964B48A9EF9DDAB3" modified="2016-07-06" version="1" fragment="single">MDELNVCTQGENYSAQQGSFEGPEKLLEIWFSPASESLRDHQNLKKASSSSSLSSSSSSSSSSSSSPSPSSSTQDLSESHPPSPKDSLTGLRTVSRAVWDDMLAIVKCTVLNVITSTDVDAYLLSESSMFVYPHKIIIKTCGTTTLLLALDRLLEIAHETCGFEKVWRVFYSRKAFMFPERQSGPHRSWDNEVDFLDRYFDNGSAYKIGKIESDSWFLYITKPADDVLHHPQPRTHPHAHLQAAAHEQDYMSGASTPCASDSEDLSPFGNQGHPSYPDQTVEILMTRLGKEKMKKFYHDSEKTEPGTVGGRWVDAETGIGALYPDALLDSFLFEPCGYSSNGLAGTRYFTIHVTPEDNCSYASFETNIPVENSHSERGKQAGVTPIEALVSQVVKVFDPQSFTVTFFTSHHKEHHSHSHMVRSMVHVKGYKRTDRTLYEFDGYDLVYGHYTKQEFDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NLV4</accession>
    <name>A0A167NLV4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_166204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294270.1">
        <property type="nucleotide sequence ID" value="XM_018435379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NLV4"/>
    <dbReference type="STRING" id="763407.A0A167NLV4"/>
    <dbReference type="GeneID" id="28996285"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166204"/>
    <dbReference type="InParanoid" id="A0A167NLV4"/>
    <dbReference type="OrthoDB" id="2384193at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="209" mass="23850" checksum="717F0F10328FAF22" modified="2016-07-06" version="1">MTHLSDFSFLQRVVSISYLTLWYIYRVCQLDRFQCFSPSRIRKGELKSIVSLLILIMLPFQLTYAFVLDVASSTVKYEEGYIQHNGQYVTKPEMLWSQANKDYVVPTDYSLCIGFSLQTSTLLLLQCFWNYLANLVAGAKFMSSKEFKCYIVCVDGLTGKQMLNGNKLTADFLISNINVASIVVWVIVILIFHPAPENPLLNNSPRITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NMJ7</accession>
    <name>A0A167NMJ7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fcf2 pre-rRNA processing C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_132323</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294324.1">
        <property type="nucleotide sequence ID" value="XM_018429487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NMJ7"/>
    <dbReference type="STRING" id="763407.A0A167NMJ7"/>
    <dbReference type="GeneID" id="28990393"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_132323"/>
    <dbReference type="InParanoid" id="A0A167NMJ7"/>
    <dbReference type="OrthoDB" id="427886at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039883">
        <property type="entry name" value="Fcf2/DNTTIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014810">
        <property type="entry name" value="Fcf2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686:SF12">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08698">
        <property type="entry name" value="Fcf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fcf2 pre-rRNA processing C-terminal" evidence="4">
        <location>
            <begin position="227"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD76284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="347" mass="39722" checksum="0F494CF757CF690F" modified="2016-07-06" version="1">MPVTRLQRQKMADKHEEPVEKVALQTKAKKPISAIQAKKLRAAENTKTAAENTKAAEAAANKETTADAVKATEAVERKEKKIKKVIFADEKSDEEPEESASEESASEESASEESGSEESEDEDLDVLLNKAKAVLEAQKAQEENEESEETRIRRLNLSKLDAGVSVKQSLYITQDNKRAYLDKASVSLVDASDTDKDDKKKEALVILKANKSEEAQLTKKERQLLRAKSTGKGWFDMERPEITDEIKRDLQIIKMRHVLDRKRHYKKMGKNYNPKFFQVGTIIESPTEFFSSRIAKKDRKQTLVDELLADEQSKQYFKRKFDETQERTTNGGKKHFKKLKQKRKWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NNM3</accession>
    <name>A0A167NNM3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_180641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294398.1">
        <property type="nucleotide sequence ID" value="XM_018438344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NNM3"/>
    <dbReference type="GeneID" id="28999250"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_180641"/>
    <dbReference type="InParanoid" id="A0A167NNM3"/>
    <dbReference type="OrthoDB" id="2131431at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="419" mass="46007" checksum="CC1FB733AF97C13E" modified="2016-07-06" version="1">MNDSSVTDWTLERHCIDGVCHCDWRLTVQDCVESHALYVVHVINIALSGLVSILAIGILYDRLVLKGHRLFDGNIAKGCLRPKPIDSMMFLLTFFNILRLISSVIIVADIAPGNMIVRSFMFEIPWQFGYGGFSLYLVGIAQTLADSHRAIATGWLPSPRTVDVIGLSFFLAPFILNNICSLVAGSLAKILFAGVRLVGILNRHIAKFQTSGPRFTTVKTGIFKIKSVMSILSICLMLFAIFLLLYGALRNSITVNPVGSVFLAVIWSYLAGISTLSLEISILFNPTINENTDIGLKSSSGGDKSNNLFETQNSGLPSVMHDKSFQGTLSHNAFDDLKQQQLQYQQATQKHAKGVGAANNVNTTILTSRAGIPLEDLSYSDSKDNYKSPHWADPKQDTEACNHIDEALFSSQVDLMDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
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    <name>A0A167P7H8_PHYB8</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_141296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295446.1">
        <property type="nucleotide sequence ID" value="XM_018430560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P7H8"/>
    <dbReference type="GeneID" id="28991466"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141296"/>
    <dbReference type="InParanoid" id="A0A167P7H8"/>
    <dbReference type="OrthoDB" id="6153305at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="142" mass="16126" checksum="EEC45EAC5C6B74E9" modified="2016-07-06" version="1">MFTHNRIDFWSGDIVNFMNGSTPARFLVESFHTMDNSAVFVQGYIVYILEGGQLIGVEVESTSIKLENLLGVGSTPVDVALCYSISPGKVFHLIPRHKSLLEEPHFLKRHELDETGKLIDPKLFYKMRILPIILFTNDTSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P8B5</accession>
    <name>A0A167P8B5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein ZIP4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_141345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295496.1">
        <property type="nucleotide sequence ID" value="XM_018430574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P8B5"/>
    <dbReference type="STRING" id="763407.A0A167P8B5"/>
    <dbReference type="GeneID" id="28991480"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141345"/>
    <dbReference type="InParanoid" id="A0A167P8B5"/>
    <dbReference type="OrthoDB" id="65716at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090173">
        <property type="term" value="P:regulation of synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039057">
        <property type="entry name" value="Spo22/ZIP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375:SF2">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="779" mass="90282" checksum="72EE5D3CAC1268E7" modified="2016-07-06" version="1">MSESRQLDLLEYANQVINTKQLEPEYMLPHLCQMLKTIDILAKKDRICSLSFDSLYKTKGIHLWNTATLLTQDGLDAKDWCTLHALLRHVGYYMIQLGTTDKSTDCGDYERAEKAFEEALGWKHKAESTSSLSKPDRTWSYQHMDTSELFMFMAELASRRGEWRNAEELFDKASDSISIYDDNNKTQKTEFMLRLCIIVGTELSHTSAKDALLRLLQMYSNRLEDSLSSNLTKMLLRISSDMHKDVVYYMARLFILIKVDNPVKITVERVYFQAMEKCSVQTGDMLMNTLRNLQNIVQADTLVSGLDLLIQRNLNTNHPKSDDLATFQTLTLFKLSFIAKCTPQDISATEELLESTMNGVYLLREEMCTVDLQLFQMLMWRIGDCFYEKQDFSHALVWYKHTWSLCLASFPKDPNTLVLARKLAVCYLEADLPERALHYLSESFPDDTFSNEDYILLFDISIKLSMWSKALLYLENLISSKGLEMYELLSANQPKILHCVFAHVWNLYQKNGPDTTTYFDILTLARWMVKLGINQDLTRLEGNDSQTYNDRQKVCALMCATAYVFSDFPKEDNVYKELSDILCQLKNTNEDVDNDKNKDPWTSIVQLFEIEAMVKLGHFEEAAKAQYAQTSENASAGRICGRMTAAFLQVQCPIQILIRVLEALIGLFYARKRPDEVDRCAKWTRLYLAISIEHDKKRTLELLQKTLLYMGCETYPQDELYYIVVVTWNEGVALSYSHDSDKARQWCQLTFSLLKYMKNKEKLKDEMTQAYALMMRFNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PKD0</accession>
    <name>A0A167PKD0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_102003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD78119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296159.1">
        <property type="nucleotide sequence ID" value="XM_018427651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PKD0"/>
    <dbReference type="STRING" id="763407.A0A167PKD0"/>
    <dbReference type="GeneID" id="28988557"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_102003"/>
    <dbReference type="InParanoid" id="A0A167PKD0"/>
    <dbReference type="OrthoDB" id="2439011at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="168" mass="18922" checksum="F18FE736CDA849DE" modified="2016-07-06" version="1" fragment="single">KPENIILVGLMPGPKEPKSEEINHYLKPLVEKLETLYVGMKIPTFECPSGVNVCAVLLMVACDISAAQKTSRFTSHNSMCTCYKCNHQFPRLPNGINVDFSGFVFSQWNLRNGVESRLHAEKWESASTPSGRHQLEVENGVQWSQLYCLGYFDLVCGTIIDPMHNLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PKK5</accession>
    <name>A0A167PKK5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_141993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD78126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296166.1">
        <property type="nucleotide sequence ID" value="XM_018430722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PKK5"/>
    <dbReference type="GeneID" id="28991628"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141993"/>
    <dbReference type="InParanoid" id="A0A167PKK5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="106" mass="12010" checksum="376F7647E19BDE8B" modified="2016-07-06" version="1">MLHGDVGKMNYVHCRRGMLLAWGTMISNEYNIDEYINKGKGKSIVCRRNREWKRDFSCARKNSPLTTKGTASHQQTVDTDLPVLDTTTWPNAVPAHNTCNKATTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PM23</accession>
    <name>A0A167PM23_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_130560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296236.1">
        <property type="nucleotide sequence ID" value="XM_018429373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PM23"/>
    <dbReference type="GeneID" id="28990279"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_130560"/>
    <dbReference type="InParanoid" id="A0A167PM23"/>
    <dbReference type="OrthoDB" id="248233at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04165">
        <property type="entry name" value="GTPBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03694">
        <property type="entry name" value="GTPBP_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03708">
        <property type="entry name" value="GTPBP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000084">
        <property type="entry name" value="GTP-binding elongation factor Tu family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000014">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000091">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035531">
        <property type="entry name" value="GTPBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF9">
        <property type="entry name" value="GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="143"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD78196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="564" mass="62366" checksum="B8701966E0952D9A" modified="2016-07-06" version="1">MTNSKETDPATELALQLLNASLDDNSTMDMFECQNDLPIERTLKDRWLHSTPEDIAYFKDLLEKRMKQGRGETLLELGVEEDGAPMGLTLQEYGVCKATLGVIVKDLDAAYCELDEDPEAPNACNGEITHIMIRKKPASVEDLLEIRIAVVGNVDAGKSTLLGVLTKGLLDDGRGKARLNLFRHKHEIDSGRTSSVGAEIMGFDANSQPIVQPNHAGRRLTWEEVCQRSAKVLSFVDLAGHEKYLKTTVFGMTGNAPEFAMLMVGANSGLVGMTKEHLGLALSLTIPVFVVITKIDRCPENVLRSTVQDLVKILKGKSCRKIPLFVESKDDVVMTAQHFVTKRLCPVFKISNVTGEGLDLLRSFLNILPSFAHYDTEQPFQAEINETYSVPFVGTVVSCIVMSGVIHVGDKLLVGPNYAGQFVPTVIKGIHRKRVSVPIAKAGQSVTFALKHVRRSGLRKGMVLLTHEKDQPMPKASRRFEAEILILYHSTTIKQRYQAMVHCGAVRQTASIVAMEQQVLRTGDRATVQFEFVKHPEYLTKGARLIFREGRTKGVGQVTQLLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PRC4</accession>
    <name>A0A167PRC4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine-rich transmembrane CYSTM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_69658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296437.1">
        <property type="nucleotide sequence ID" value="XM_018442141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PRC4"/>
    <dbReference type="GeneID" id="29003047"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_69658"/>
    <dbReference type="InParanoid" id="A0A167PRC4"/>
    <dbReference type="OrthoDB" id="2207060at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12431" checksum="B1B42ED9C3C8D60B" modified="2016-07-06" version="1">MDKPFDILNPTPAPLPPPRYRPLSETSVSDPYSTPPPAYQPSLQYSNSLYILPSQQTRSSKPRSPIGAYYYQPLPTPEIKVIHHKPTRSHDACCWGCLVAVLLCFGIKECC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PUT8</accession>
    <name>A0A167PUT8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_179598</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296614.1">
        <property type="nucleotide sequence ID" value="XM_018438173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PUT8"/>
    <dbReference type="STRING" id="763407.A0A167PUT8"/>
    <dbReference type="GeneID" id="28999079"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179598"/>
    <dbReference type="InParanoid" id="A0A167PUT8"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942:SF63">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="184"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="335"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="436"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="445"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD78574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="53535" checksum="252AD11088B5A7F0" modified="2016-07-06" version="1">MNVHKTTVALSALSRASLPRSAIRQSITSFPRENLLLPVNVTVRHAHNGNCDVYRFHHVKTLTKLNQNLLGAISNKNEEAVWRVYTELSETKKLNSLTAEQHSMALRAFRLKNHVSYGSEEIENMKNRILFIVENMKSLNIGLDLRDYNHLLDFFGRAGDWQTCVHYWDEMMAEPKGLWGVSPDIHSYNFYMRGALQGKKPTEVFNVLALMRKDNMEPNVFTYSTLIEAHGLMGDIRSADAVYQKTFLDATAAASPESAPGFFSFLSFQGGKQELTNVAARAVLELLPISPESGALKPNTSVFVALINAHGRHGNVKGLSHIQHKMMPAAKVQPDIKVYNALIRWYCKHSDIESVKQVFSDMEKNNIKPTVTSFNYLFRHEALKEKQTQKAEKLLDLMKRVYNITPITSMYRTLMKIHHHHNRNEDAKRVYRDYSKANGIRTESEAESETESGAEAESESPKLSTPTPAVTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PWU1</accession>
    <name>A0A167PWU1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CipC-like antibiotic response protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_107153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296718.1">
        <property type="nucleotide sequence ID" value="XM_018427981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PWU1"/>
    <dbReference type="STRING" id="763407.A0A167PWU1"/>
    <dbReference type="GeneID" id="28988887"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_107153"/>
    <dbReference type="InParanoid" id="A0A167PWU1"/>
    <dbReference type="OrthoDB" id="9895617at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022234">
        <property type="entry name" value="DUF3759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450:SF1">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12585">
        <property type="entry name" value="DUF3759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11787" checksum="D732C65BD6D05554" modified="2016-07-06" version="1" fragment="single">FFGQQHEQVNKHDESEHKGSISHEVIAGAAAYEAVKAYNDHCEKEGKPQDHTIAKEILAGFAAGALDKLIETKGLDYLDRQKAKKDAESQVKQYYDEEQLAEKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PZR0</accession>
    <name>A0A167PZR0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_140883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296869.1">
        <property type="nucleotide sequence ID" value="XM_018430473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PZR0"/>
    <dbReference type="STRING" id="763407.A0A167PZR0"/>
    <dbReference type="GeneID" id="28991379"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_140883"/>
    <dbReference type="InParanoid" id="A0A167PZR0"/>
    <dbReference type="OrthoDB" id="2288953at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="439" mass="48874" checksum="0753C2D57D58B80D" modified="2016-07-06" version="1">MSSITNLLPYECQLCHTHYSNKAIAVTCQKLYLGKILKAMMNGEVSEDDSSSESSQFMLPAISSLMLEENTNMISNEISDISNNTDLDEPMYDIEYESNMEESVDMDGSKSATSPVVFDFSQPSPVPSNNDAKNLEFIRIINDFSISYQAHEKLAVHLNSILGMSTEIMYRVCTPYLGKELLKCFSGVEKTLYDVCQSGCMIFNKAEEVACKHCGEACYKSNKTDKDGMPIAEKTMVQISLTRQIALSLANSSIRHEMLYHHSYEQKADIFDRHAYQSIKHLFSGENDVAISLSVNGFAPHNVPGSITILHATVLNLSPMVRYEKSWMLQIAMISGPSAPLEFWSFLKPTLADLKVLQEEGMVVVTSTLTICTKVHILMVTDDILAVARLACLTGHMSKSGCQICNAVGQTPGRGQYFRSLPDTTMRTLESFQNFDPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q2P2</accession>
    <name>A0A167Q2P2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">p53-like transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_179761</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296998.1">
        <property type="nucleotide sequence ID" value="XM_018438202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q2P2"/>
    <dbReference type="STRING" id="763407.A0A167Q2P2"/>
    <dbReference type="GeneID" id="28999108"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179761"/>
    <dbReference type="InParanoid" id="A0A167Q2P2"/>
    <dbReference type="OrthoDB" id="2288358at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052605">
        <property type="entry name" value="Fungal_trans_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF2">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NDT80" evidence="4">
        <location>
            <begin position="87"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="2">
        <location>
            <begin position="87"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="443"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="446"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="545"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD78958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="612" mass="67713" checksum="720231338EDE3842" modified="2016-07-06" version="1">MQDNKWSPAQESSNYMALSNYPYSNEYPPHPAGSNSSGSSHLAMSQPIQGMLSMSQPTTPRPDVTSPTSPDSAKMSGPPNLIRKRPPLPSRAASFTTTTFHSNPYPNGAPIRRRRTESSMFTFETGPGFSNTKQLLEIWNMDQTNGYHLQIQVKMDRGFFRADQDWTCYRRNYFQVSAAFEVHGLNYLLQSPEIPCLVKSENQELHQVDYFTIGVGARISSGEKKIDLVQHTPKRDKGPQMVPEPRMVRAGGNLHLATVGSNHNVVTFERMQFKTATANNGKRRAAQQYYEIVVDLYAKTTSEKTFRVATCVSAPLVVRGRSPGHYADSHTRYQDIENGAGGVGGVGVGGGGPSVAGPPPSAFGMGMGEEQRYGGGPIHSRYMSLPTSPVNDFGYSSGYQGYPYQSYASVVSPTNLPSSARSDDSNQSMRADVPFMVNPAPYSISQQQQQQQQQQQQQQGPSGSNNTHDGAYFPSGHPMDTSMAHSRITSSSSSNNSQSVYDRQEPYSSIKPEPIGESMGADKYWPGPPIQRQYPPNDVNVRYAPQHHHQQQQQQHHHHHQQQQQQQQQQGYVGSGYPYANHHDNNGPFPPVLDPSINTSRPMSPDKHFSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QB86</accession>
    <name>A0A167QB86_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_129896</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297448.1">
        <property type="nucleotide sequence ID" value="XM_018429316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QB86"/>
    <dbReference type="FunCoup" id="A0A167QB86">
        <property type="interactions" value="169"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QB86"/>
    <dbReference type="GeneID" id="28990222"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_129896"/>
    <dbReference type="InParanoid" id="A0A167QB86"/>
    <dbReference type="OrthoDB" id="10260443at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="SLC13_permease"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SPX_PHO87_PHO90_like"/>
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    </dbReference>
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        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF92">
        <property type="entry name" value="LOW-AFFINITY PHOSPHATE TRANSPORTER PHO91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="367"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="546"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="591"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="618"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="691"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="731"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="779"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="9">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="106"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="253"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD79408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="802" mass="88348" checksum="41E50FE6C42CE6E6" modified="2016-07-06" version="1">MKFSHQIQFNAVPDWADHYLPYSNLKKLIYSIEKDRVNGTHEHSQDLEYAPSEQTALMRDQIQDSNSVFAAALDKSLDKIVKFYAKKETELYDELDQLVLEIESLDSSRRPSHQDEEITLGDTPHPHHRADFPRRESNLDGDSLPANIISQNLTDTYCDHEAGIEPGGGGGGGGGGTTGWSNNKISPDATSELRKRTIDLFVLLSELKSFVALNLTAFAKILKKYDKITNSNLKRDYTASHVSQAYPFKSATKSRLNERIQQTERAYAFLETNNNLDQAIDELKAHLREHIVWERNTVWRDMVGQERKVQTVGVGESDMMQIKTPCGSLKIDREQAIHTFFLVASILVFVILLQVEIFAHIEQNRCFAILVFASILWAGEVMPLFATALLVPVLVVTLRVMRSEDGNFTRLSAPDATKRVFASMFSPVIMLLLGGFAIAGALSKFGIAKAMATFVLSKAGTRPNRVLLVNMLVATIASMWISNVAAPVLCFSLIQPILRTLPVDSRFGPCLIIGIALASNLGGMTSPISSPQNIIAIQNMNPAPSWGVWFAVAIPLSIIGNIIVWMFLVWSYEPEKQTPHIHAIRASNDPINSTQIYVCLVTLITIILWCLAHTYQEIFGDMGIIAILPLIAFFGTGLLTKDDFNNFLWNVIMLAMGGIALGKAVESSGLLQAIAVQIEALVVDMNAFQVLFTFSCLVLVIATFISHTVAALIVLPIVAEVGARMDDPRPSMLVMGTAFMCSAAMGLPVSGFPNMNAIAQENELGQPYLTTKDFVRNGIPSSVFAMICVTTIGYLLMTVVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QIP4</accession>
    <name>A0A167QIP4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CNNM transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_106954</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297797.1">
        <property type="nucleotide sequence ID" value="XM_018427970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QIP4"/>
    <dbReference type="STRING" id="763407.A0A167QIP4"/>
    <dbReference type="GeneID" id="28988876"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_106954"/>
    <dbReference type="InParanoid" id="A0A167QIP4"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="4">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD79757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="301" mass="32745" checksum="386F7948079D353A" modified="2016-07-06" version="1" fragment="single">LSICILIHLVYIILTGLTLGLMSLDETNLAILAVAGSEKQRACASRILPIRKNKHMLLTALVLTNTVVNETLPVVLNGIFGEGYIAVIASTLLLVIFSEIIPQAICTRHGLAVGALFAIPVRALMMLWYILAWPISKCLDLMLGEHESPIYRVQGKYIKLNELIRMHDSSLANAGSLSHRTATIIQGTLSLQTKTTGDLAIPLDNVFMLSHDTLLSKDVMLKIFESGYSRIPVYETQAASTGDSDIKALQNNLAMINPEDAVSLSDITLEPVLHVPTSYSATDLLAALRKSSGTAETWSCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QJS3</accession>
    <name>A0A167QJS3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_98693</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297847.1">
        <property type="nucleotide sequence ID" value="XM_018444068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QJS3"/>
    <dbReference type="FunCoup" id="A0A167QJS3">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QJS3"/>
    <dbReference type="GeneID" id="29004973"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_98693"/>
    <dbReference type="InParanoid" id="A0A167QJS3"/>
    <dbReference type="OrthoDB" id="77989at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="284"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="36"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD79807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="40077" checksum="A90D5C375A0CA1D3" modified="2016-07-06" version="1" fragment="single">VLKYITTAINSPFEVSKTLLQVQYMPHEDVEVLATTSHQQDDNHDHSDSTDEEIEEDEEDDFYGTGGKRRHSTEGLDFSTASLDADNPAFKKKVSLDESGYVVRTSVYDDSTRPTHQIKPIEGGVWQGIRLLIKQPHEGWRSLFKGQYTSWLCEVLHLFLQPTLEGTLNDMFDLYDDTIPLVHLDRVGPNLATLVASNLIVGFILSPLELIKTRMMVQSASPLQRKYKGPFHALRTILNEEGGLWGLYLSHNLVPTLLYHSITPLLQNTIPLIIDRVFRISANDSPFLYGLAELGLNTLELIITLPLDTIRKRLQCQIRSRTPGNKRFESVVALRPVPYTGIMDAFYRIVKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QL28</accession>
    <name>A0A167QL28_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_157367</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297904.1">
        <property type="nucleotide sequence ID" value="XM_018433609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QL28"/>
    <dbReference type="STRING" id="763407.A0A167QL28"/>
    <dbReference type="GeneID" id="28994515"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157367"/>
    <dbReference type="InParanoid" id="A0A167QL28"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035539">
        <property type="term" value="F:8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04678">
        <property type="entry name" value="NUDIX_MTH2_Nudt15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000060">
        <property type="entry name" value="Nudix hydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099">
        <property type="entry name" value="8-OXO-DGTP DIPHOSPHATES NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099:SF5">
        <property type="entry name" value="NUCLEOTIDE TRIPHOSPHATE DIPHOSPHATASE NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD79864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="150" mass="17015" checksum="5E7F2BB6270DCCFD" modified="2016-07-06" version="1">MSDSVVRVGIGCFVTCVFEDGMKILVGQRKGSHGAGTWQLPGGHLEFGETFEDCAGREVLEETNLKLSQIDFITAVNSRMPAEKKHYVTLFMHGRVTRSEAANVKVMEPEKLEGEWHWMTWDELCQKKPLFIPLALFVDFNSLPEVLERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QM35</accession>
    <name>A0A167QM35_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_162960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297948.1">
        <property type="nucleotide sequence ID" value="XM_018434711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QM35"/>
    <dbReference type="STRING" id="763407.A0A167QM35"/>
    <dbReference type="GeneID" id="28995617"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162960"/>
    <dbReference type="InParanoid" id="A0A167QM35"/>
    <dbReference type="OrthoDB" id="2219666at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD79908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="281" mass="32414" checksum="93B5CB0C7FE1F85D" modified="2016-07-06" version="1">MDSYGPDRVILYQQKGHDLWFNRIKMSPTPGKVVYLKSAYRLSSQTVCKVSALSIKTTSSQPKNQTNDENNIKIYDYKTSVLLAFNVLQQPEKEQEKKLLITELGDLEPVVYVDREGEEHYLLAAPKGNIPQSSLPHTDTRYQNIGLCLIDNENSKKLVLGAKPVNVLLASSTRLKSNQLPIVGASSSNGFMPSRVTRVFIEKRKLKEIEIMMKANTQLDEIKSSNQHVLYPFDEHSQFRQLRSKLDRLSTYTCYRFSFKFTDDARKRPWTIWTIEYRSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QM49</accession>
    <name>A0A167QM49_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_162961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297949.1">
        <property type="nucleotide sequence ID" value="XM_018434712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QM49"/>
    <dbReference type="GeneID" id="28995618"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162961"/>
    <dbReference type="InParanoid" id="A0A167QM49"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="122" mass="14412" checksum="C1A42B32979190E8" modified="2016-07-06" version="1">MATNSFALSKNPSFSSEHDIKSDPVNKPSTHDLQIWIYKLFPDPLNYPEERLISIDTKELDIKTRIIKDNTIIPPKWLWDFSVIINIKNKTIFRCITRSTNGDKRNGFDRNIYLPFYIDFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QP14</accession>
    <name>A0A167QP14_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_140001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298029.1">
        <property type="nucleotide sequence ID" value="XM_018430316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QP14"/>
    <dbReference type="FunCoup" id="A0A167QP14">
        <property type="interactions" value="236"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QP14"/>
    <dbReference type="GeneID" id="28991222"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_140001"/>
    <dbReference type="InParanoid" id="A0A167QP14"/>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="5">
        <location>
            <begin position="147"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD79989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="298" mass="33074" checksum="6E34B69B30D35E8C" modified="2016-07-06" version="1">MARISLHTIRQGQHLLLRATEKASIVSKVDTSPIQCTRFYSLPSLSEVDSTTTIITSGHQLSEQGRHSSLSINTMNTYAVSSELSRYLKKPMCSPSWTPKQTLSECTSISSASSISDSLNLHEHNPPLRAPCLPPIKFGHRDSQTYECLDKNLAENLRSHLPSRIATSTQWDLLYSLDQHGASLNTFYSCLKDQGPCLLILENSEEETFGAYISEPFQSGSLYYGSVEVYPWTMANNYLIFSNQNCIALGGGNGQFGLWIHSDLMHGHTESCATFGNPSLGNDSNFECVALEVWGFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R682</accession>
    <name>A0A167R682_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ras GEF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_104416</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298987.1">
        <property type="nucleotide sequence ID" value="XM_018427842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R682"/>
    <dbReference type="STRING" id="763407.A0A167R682"/>
    <dbReference type="GeneID" id="28988748"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_104416"/>
    <dbReference type="InParanoid" id="A0A167R682"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="4">
        <location>
            <begin position="6"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="3">
        <location>
            <begin position="171"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD80947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="47760" checksum="62989523CDDDC2B4" modified="2016-07-06" version="1">MVLLNLDGTVKGGTLVALVERLTMHNALDTSYIATFLLTYKSFCKTEEFVECLENRYNMHPPEGLTPDELENWTERKQKLVRLRVFNVIKNWLENYYNREDEMILDRLEFFTTTVIRDTSSFAADQLERLIRKRRDTDAYEDVRTMVPNEKSRPIPIIPKNSACLRLLDADPLEMARQLSLMDFKLYSTIRPIECLSKAWSIDDSEGNIAVNVKQSIDYCNRLTCWVTDSILSHDEAKKRAVFIKHWTQVADRCRGMNNYNTCMAILSAFDNSAIGRLRKTWDLVGSRTNQMLGHIRKLMGANRNFTEYREMIHSINPPCIPFLGIYLQDLTFIEDGNPDFLKASNTLINFAKRQKTADVIREIKQFQSPPYPLQALPRLQAFIRQNLNTDWDVDQLYKKSLMLEPRETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R8V7</accession>
    <name>A0A167R8V7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleoside diphosphate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_161762</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299167.1">
        <property type="nucleotide sequence ID" value="XM_018434460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R8V7"/>
    <dbReference type="STRING" id="763407.A0A167R8V7"/>
    <dbReference type="GeneID" id="28995366"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161762"/>
    <dbReference type="InParanoid" id="A0A167R8V7"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46161">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46161:SF3">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE DDB_G0292928-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="9">
        <location>
            <begin position="10"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="7">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD81127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="154" mass="17368" checksum="7CD16CA59C04F5FD" modified="2016-07-06" version="1">MTPITHAVKRQLTLALLKPDICASQKLQVRVHEAIEAQNIKIVSQRPVLWTKEEAGAFYAEHKGKFFYDRLGPFQALVLSSPDAIKEWRALIGPTHPCRARIHQPTTLRALYGLSDTRNSFHGSDSDETAKNEIAFFFPELSIDNLLKVQDSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R9A1</accession>
    <name>A0A167R9A1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_72976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299194.1">
        <property type="nucleotide sequence ID" value="XM_018442754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R9A1"/>
    <dbReference type="GeneID" id="29003660"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_72976"/>
    <dbReference type="InParanoid" id="A0A167R9A1"/>
    <dbReference type="OrthoDB" id="2281581at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="529" mass="58970" checksum="0A2B15ACA802B786" modified="2016-07-06" version="1">MPKLSNKYCPTVPILDDQQHFLRQEIAELILKKTVEKQPVVCDTKEEWWSLTGIQPQEVKQTHQGTPLQDRDTAEYMQIDPPTRLSNFLGPVRRLPSYLSPQGIKEILTFSLGGSRLPVPYNSFWSIGFPMVVYQSYLSSTRMGSNLGNANQCLSQGLDYYQQLIPRINHSYQDVDEQAHFSWLDIKHKEIVTPAITTTGTFGLSFGHQEHGFQDSRYQIEGFTTINTTTDTTQIYNSSFGPQSHDADPGSHDRTLSSQTLHATLDVVQEQLREEERRVGYTTTIASDLPSGTSLVGMQYLTMERLIAPTTTKQACSVRRCEQHQMGMCTREQDNPWILVPPVDHNVYQLVGNEGGKSCPTNLPLPTALIHTCQNGQHYLNGVPEQAEWLQGLSSDDTGYQDMEAVSALWVEVDSPAYSRQGECGGGFGISLHIYKELVEAVLFSFSSYLTDMGSSFSGFICGPADPPSPNFCFMETRSEGDSNRCNVDTMVSMGQLLPEFSLEPDWTVLAQDLARGPSGDNSSTDLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167RB61</accession>
    <name>A0A167RB61_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_72776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299307.1">
        <property type="nucleotide sequence ID" value="XM_018442714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167RB61"/>
    <dbReference type="GeneID" id="29003620"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_72776"/>
    <dbReference type="InParanoid" id="A0A167RB61"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20627" checksum="CD18CA6DCE36AD96" modified="2016-07-06" version="1">MPSVVSVNSSSSIDDDLDLEVKYHPLISQLINSYIKKPNFVSTDLLKVAENNNRLAWSMTGTYGNKYNKALALALFKYLRSQRCYTNVSKSVTKNIIKNHYQNQVRVFQTSAEKIMARNKGGRKCNRKKTLHTFITSIDKLTVICLKKNSESLKKCIPYEKEVSIHKNLTVTLPDWCFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N2S7</accession>
    <name>A0A162N2S7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_176301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441011">
        <property type="protein sequence ID" value="OAD65254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283294.1">
        <property type="nucleotide sequence ID" value="XM_018437727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N2S7"/>
    <dbReference type="GeneID" id="28998633"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176301"/>
    <dbReference type="InParanoid" id="A0A162N2S7"/>
    <dbReference type="OrthoDB" id="2417874at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="150" mass="16748" checksum="0E6BFB25F85215DC" modified="2016-07-06" version="1">MTDAATHFYEKQYSVDPINDSPVEDLLSHVPSNQFFSEATRSSMTFSLAFDGICAAVGRSPHYSSPGPDSRATVLNTLILSRIWHALRIKTVLKRFFDELCSILGRFLRRNMLSMAILSSMFSETAKRLRRVGLADSTESTDYAIATTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N3X3</accession>
    <name>A0A162N3X3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_73000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the nucleoporin Nup85 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286308.1">
        <property type="nucleotide sequence ID" value="XM_018442758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N3X3"/>
    <dbReference type="STRING" id="763407.A0A162N3X3"/>
    <dbReference type="GeneID" id="29003664"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73000"/>
    <dbReference type="InParanoid" id="A0A162N3X3"/>
    <dbReference type="OrthoDB" id="17644at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011502">
        <property type="entry name" value="Nucleoporin_Nup85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373">
        <property type="entry name" value="FROUNT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373:SF21">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07575">
        <property type="entry name" value="Nucleopor_Nup85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD68268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="565" mass="64992" checksum="2DB8B2489D25A580" modified="2016-07-06" version="1">MYHKLATIFRSLHYLNPVPDTTVLSIRTGRYSALLNEFPKESHGPYWREPPEKRASYLHKVALWDLCQLFYFPTSEQECCSAALIRWLKATDNKSVIKFYIQDIYNDKTPIHHAQFWPAVFKLIIRGELRALTSLLTQARKRVIEQSHDDILLLLISTFLQAVSKFPILEDPPQQNYLQSKQAWQQNCLELTEKIRDFTVGTSTISEFAICVLDGIKLLQGDQNTVNRLSETKLESLVALAYYAYTHASRSNIQGLAKEMWTDAEVELKDFKNVFQGNIEAILKEDKLDLWYLSHLSDVLVLFGVDSIKDKRQNSVIAYSKHLLDNGLWLEALDYMSTCGSQGRDCMHKAIQQLDIKDEEMAKELLACCDNFYMHDEKNRLYKETGNILQNSRKFSSAIFYYDQAGDALAVDNTFKSAMNNYVNTGQLTDLGDLSPDLKARCNGPYAKFYLGFFDLHSFIEANDYKKAAKQLHELLKSPSSPIEFIPMLYVRSVGLLQNPALWFSAEEYACLELRFEELSQNEDLTGYTLLGNMLLKDTQLEGIMIRDTFFDLLSLVLKRSPYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N6M3</accession>
    <name>A0A162N6M3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_79695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289698.1">
        <property type="nucleotide sequence ID" value="XM_018443492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N6M3"/>
    <dbReference type="GeneID" id="29004397"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_79695"/>
    <dbReference type="InParanoid" id="A0A162N6M3"/>
    <dbReference type="OrthoDB" id="2290405at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="158" mass="17980" checksum="A9085FBACDBA9845" modified="2016-07-06" version="1">MLMFGNDSRMKRLLASRHRCRESLNIILPKASSFTCWFSSEHESPRQTDHSSQKEQPIPWQKPVLTSPIAVDLCEKSLEAEYQITSIPERHTSRFYHQNPDVQAQLERVSQSEQMALLSKHLRKQKLQGITATSSVQSIDIDIDTSSTPSKIDSNATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N8A9</accession>
    <name>A0A162N8A9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_135206</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288669.1">
        <property type="nucleotide sequence ID" value="XM_018429703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N8A9"/>
    <dbReference type="FunCoup" id="A0A162N8A9">
        <property type="interactions" value="74"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162N8A9"/>
    <dbReference type="GeneID" id="28990609"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_135206"/>
    <dbReference type="InParanoid" id="A0A162N8A9"/>
    <dbReference type="OrthoDB" id="272245at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11367">
        <property type="entry name" value="RNase_PH_RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="31"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="199"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD70629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="303" mass="32900" checksum="757012014E10FC28" modified="2016-07-06" version="1">MPIPVISPAEKSYIEQGVETDCRADGRGRLEYRHLVLETGLLSQASGSARCRLGNSDVLVGIKVEIGEIEQDQPNQGRISCNVECSPSASQQFEGRGADDLNNTLTLALERLLSGPQSGLDLDKLCIIPGQQCWVIHIDAMVMDCAGNLFDCIVMTTRAALFNTRIPKTEIQDLGDGEFEFEVMDDVEDAEAIAGWENLPMSVTLYKIGERYILDPTILEELCSQVTLTVGVNKTGQVCGVQKGGSGSVDPSLLTEMIQTATTLAGPLIQQLDAKLAEEEKNVLDKRRKGEPVQKLGFFAAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N8F4</accession>
    <name>A0A162N8F4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_152063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441000">
        <property type="protein sequence ID" value="OAD66794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284834.1">
        <property type="nucleotide sequence ID" value="XM_018432832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N8F4"/>
    <dbReference type="STRING" id="763407.A0A162N8F4"/>
    <dbReference type="GeneID" id="28993738"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152063"/>
    <dbReference type="InParanoid" id="A0A162N8F4"/>
    <dbReference type="OrthoDB" id="2379842at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22744">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="36937" checksum="D58EA8FC6A5C81E5" modified="2016-07-06" version="1">MVRLRARTRDGKPAATQKTKNNKKQNKSKKEPLDLIDATKNKIKQIKKEPLDPEPLDPVDATKEIGFKRSATAQEDYQYDYRTSVGKRVKFQPGFPVSHEIVDDVKSGFNPTSDGWCGFWALAHLIYKDQEKFSLVKRDMLATLPKYSSIYASTFGTDVKQLEDIIKHGSDLCITNSNSNSNSNFIPVCLDASMWFSTPDCAQLAADTYKQPVCVYSDNPNTPSILFLPFTLPKNISKHQQPLIFNHVNNNHWTTVHLSRNISRKWLTIPELFFLGCVRNQIPDNFDTYWNKFKEFNKYDCRNAMFSFLSDQEEHVDFTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N8L6</accession>
    <name>A0A162N8L6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_183743</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441000">
        <property type="protein sequence ID" value="OAD66854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284894.1">
        <property type="nucleotide sequence ID" value="XM_018438823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N8L6"/>
    <dbReference type="STRING" id="763407.A0A162N8L6"/>
    <dbReference type="GeneID" id="28999729"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_183743"/>
    <dbReference type="InParanoid" id="A0A162N8L6"/>
    <dbReference type="OrthoDB" id="2281372at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF23">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007838032" description="LysM domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="27"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="302"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="58"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="215"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD66854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="354" mass="40391" checksum="B6BA1C76765FB245" modified="2016-07-06" version="1">MKLNLFTASLLLLSSMVLASPGNSCATRHAASRRDTCGSIAREYGISVQELQRWNDNLGGNPRHCNKPVPGRSYCVKPRRRSNHGEDYGRDHGRDDRRDHGFHKRAKGLGDHHGIKEIKKHKPFKHHKPKPFKHHKPKPFKHHKRKEVDVTEDVDIIELEKRKAGPSNAHDKHPVKHHKPEPIKHHKSKPIKHHKPEPIKHHKPEPIKHHKPEHHKREEHGKGPSNDHGKGSSNEHGKGSSNEHGKGPSNEHGKGPSNDHGKGPSNEPGKEHGGHQDDRNDHRRPNTRGLHLAPHTDPNCRRYYVAKRDDSCRGIARRNHISENQFYKYNQGLRRRGDHQCVNLSPGRAYCVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NHB2</accession>
    <name>A0A162NHB2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Ubiquitin-like protein ATG12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_116183</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 7">Forms a conjugate with ATG5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Preautophagosomal structure membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATG12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287704.1">
        <property type="nucleotide sequence ID" value="XM_018428508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NHB2"/>
    <dbReference type="FunCoup" id="A0A162NHB2">
        <property type="interactions" value="249"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NHB2"/>
    <dbReference type="GeneID" id="28989414"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_116183"/>
    <dbReference type="InParanoid" id="A0A162NHB2"/>
    <dbReference type="OrthoDB" id="10003551at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01612">
        <property type="entry name" value="Ubl_ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000150">
        <property type="entry name" value="Ubiquitin-like protein ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007242">
        <property type="entry name" value="Atg12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385">
        <property type="entry name" value="AUTOPHAGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04110">
        <property type="entry name" value="APG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="5 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD69664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="86" mass="9672" checksum="26383A8CF80B2B89" modified="2016-07-06" version="1" fragment="single">VIVRFRAIGNAPILKQSFYKITASNKFQTVIQFLRKELKYQGSDPLFLYINSAFSPSPDATVATLHKCFNTDGHLIINYCTTAAWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NJ43</accession>
    <name>A0A162NJ43_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Xanthine/uracil permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_132855</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292738.1">
        <property type="nucleotide sequence ID" value="XM_018429526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NJ43"/>
    <dbReference type="FunCoup" id="A0A162NJ43">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NJ43"/>
    <dbReference type="GeneID" id="28990432"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_132855"/>
    <dbReference type="InParanoid" id="A0A162NJ43"/>
    <dbReference type="OrthoDB" id="431212at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005345">
        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015853">
        <property type="term" value="P:adenine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015854">
        <property type="term" value="P:guanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337:SF1">
        <property type="entry name" value="XANTHINE_URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD74698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="584" mass="63990" checksum="B0EC9653803FB02F" modified="2016-07-06" version="1">MTWIDTLNSAIAHSFIGRHFQLEGSGARRERKGTLFSTEIRAGLTTFFSMAYIISVNSSIISDSGGTCVCEFTEADPVCSLNEDYMSCVYQVKLDLIMGTTVIAMISSILLGVFANLPIGMAPGMGLNAYFTYTVVGFHGSGKVSYETALAAVFIEGLIFFVLSIFGIRQWLARIIPMSIKIAMGCGIGLYLCFIGVQKSAGIGLVSLDMSTLVTLGGCPTEALSAEGVCQWGRMESGTLYMGLLGLVMMAILLMYRVRGAILISIIFIAITSWPRVNKVTYFPYTPQGDLMFDYFKKVVTVHKMEHTLGRFDFNLTGKDIWIALITFLYVDIMDTTGTMYSMARYGGFTDKAGDFEHSTWAFMTDAITITIGSCFGSSPCTAFIESGAGIAEGGRTGITAIATAFGFFVSIFFSPIFASFPPWSTGPALIIVGSMMTSGIRNINWDYPGDAIPAFITLAIMPFTYSIAYGVIGGIISYVIINGFAYVLDKATGGYIRPDYSQREDWWTAAMSRSFVPTWIQFLIAKSRGQSFDWHKDEYEFEDDVKLETPTGVITNHSGISQDNISARQDFTSKAEKTEYYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NK81</accession>
    <name>A0A162NK81_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sas10 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_111594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293028.1">
        <property type="nucleotide sequence ID" value="XM_018428221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NK81"/>
    <dbReference type="FunCoup" id="A0A162NK81">
        <property type="interactions" value="945"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NK81"/>
    <dbReference type="GeneID" id="28989127"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_111594"/>
    <dbReference type="InParanoid" id="A0A162NK81"/>
    <dbReference type="OrthoDB" id="203440at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF9">
        <property type="entry name" value="NEUROGUIDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="31595" checksum="C018508578AE203F" modified="2016-07-06" version="1">MSYFLEKSELTKLLQDLKAKTIELKTQLQPVMQKLADGEIKTSKGVSFLEVKYQIMIQYILQLTFYVHLKLSGKQVENHPVVKSLVELRVILDKMKPIEVKLKYQIDKLVRTAVMGTQKAETGAVTSATAVANDPLAFKPNPMNLLNRNDDDEEEDDGVYRPPKLAPVNYDAGKDRKSKEERNEERLKEKASRSRVMKDLMAEMNDAPEEVDVRGGVNEGTGYGDRVDSLIAEKSQYEENNYVRLAVTRKEKKRMQSKNKMRFESEFDVRIMTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NLL2</accession>
    <name>A0A162NLL2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_143604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293388.1">
        <property type="nucleotide sequence ID" value="XM_018431025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NLL2"/>
    <dbReference type="STRING" id="763407.A0A162NLL2"/>
    <dbReference type="GeneID" id="28991931"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143604"/>
    <dbReference type="InParanoid" id="A0A162NLL2"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF2">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD75348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="704" mass="77990" checksum="286B7CFF604A9BCF" modified="2016-07-06" version="1">MSTMIYTPTSSWSMTTRTASPTVPVPRMVTVQSLPEPRTQLLIIQDSDSEYDSESENENENGTESESECESDDSIEKSVETVAIPASIPTPALTPEPEPLSEPVQIQTQTQTQTQVQAQMQTQTQMQTQTQTQTQTQTQTQTQTQTQTQTQTQAQTQAQAQMPAPVPVQVAVKEQLPIRVSFPTPQMSFSMPLPIPVQTMPQLQERISTQERPVKPLPMIPDQLPIVVPTPSFSYRALTPIREDVDEDNKHFTESTIESCRSSAHTVSRSVSEASIQYIPDTPSEQNMQYKPHEIITRQVIPPQVIQEPVISAPQEPAPVSPQVSHHIPSPDEKTEVHEPALVPSTDVQTNTVDSQGHTRSNDGWRWTARPGMPNRPDSETVALLTDIRREIDEVKVNHQSTIGSASSTAYTATTSASSTAHSTISTVTRLCHCTKGSTHQSNCLFHTTPDPLAFPLPRLSIESFSLTHNKDALKTYRRMASKTNDSTVQMTYCTYLTQVAKIYHHKPDAVKTHRRLIEEVEYWVERLAKANLPDALIIKGRWHLQGPSSASTDLPSVGQAYQRVQLTKAFKAFQAAAKGGSAEAHVGLAEYWRACQDIDKSIECYKVAASKGHTTAAYTLAKIFLYGQYRQQKDSRLGLEYLQQAADGRGPDSGEPAYMIGCIYSGQLDLVNLASDPFLSHPHQELALHYRSKAQALGLATQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PMI1</accession>
    <name>A0A162PMI1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_171720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288376.1">
        <property type="nucleotide sequence ID" value="XM_018436652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PMI1"/>
    <dbReference type="GeneID" id="28997558"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171720"/>
    <dbReference type="InParanoid" id="A0A162PMI1"/>
    <dbReference type="OrthoDB" id="2283549at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="212"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD70336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="380" mass="43534" checksum="D6FB4AF5F5C1E828" modified="2016-07-06" version="1">MSRFDPIIELTDRYINHSSRRIAEEQKRGWVSVPEQQEEHADVYEDQEPTNEEIQEALAQYARDREQEGERIAVSLHCQGCLDPSTLSDEDSKLLFRFTQPEIRSLATLLEMGDIVYFREGTPSEFSLPMTLALMIVLRRMVFPARLVDLSLLFGKGKSTLSVIFNEMIEKIYIKFYPALKFDYCQFRESNLMRFSRAIRERSPAMYCVGFIDGTFNKIARPIADQEGAYNGHYRGHGLKYQAVVTPDGITSSIMGPDSGRNHDVRMYRESQLDAMMCVAFDFTSINGPCYYLYGDPAYTASDHMMIPFRRQTADEQELAINKSMSAVRISVEHEFTHVGSLWAFLKYSQTQRSGQSPVGLYYIVGTFLKNLNVCYNGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PN07</accession>
    <name>A0A162PN07_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_186779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292447.1">
        <property type="nucleotide sequence ID" value="XM_018439282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PN07"/>
    <dbReference type="GeneID" id="29000188"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_186779"/>
    <dbReference type="InParanoid" id="A0A162PN07"/>
    <dbReference type="OrthoDB" id="5573535at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="393" mass="44265" checksum="E8BA24648D78F7FA" modified="2016-07-06" version="1">MSKRAASPNLKEETSSSKRVCRTEENHSTGCNDPDCNGCDVGNIEITFVGDNGEDKAADPTAQELLEMAIEEAGNTEAKPEVVQRLFDMAIEKFEKAEPKNRIGYATCLIELGQAIKVEESLREGLDILRGEIKKPDVGPLAQFILARAAALLAADIRQKKNALFEEARAELVDSDGEEDEAAMDELNKKQAITREEIKLYKEAIAAIEKGFVEYDPKNEEQTKALRVAMRQLLSYGQLLEDPSHGIHVDTLMNKLVSYIQRLENEADSSLLTEWAACLLHKCKFEEIEKQKELCKEVEKLLLKSNNVYKEAHNEENPWGWELYAMLKMNQSNLAENEDEVLEKFGEAVDTYKKALELNPENKELAAMVSMLEGSPEDEEDDDEDEEEGEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PQA3</accession>
    <name>A0A162PQA3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tropomyosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_187469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD71916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289956.1">
        <property type="nucleotide sequence ID" value="XM_018439385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PQA3"/>
    <dbReference type="STRING" id="763407.A0A162PQA3"/>
    <dbReference type="GeneID" id="29000291"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_187469"/>
    <dbReference type="InParanoid" id="A0A162PQA3"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD71916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="14158" checksum="A3DB1D1ACD6F92DD" modified="2016-07-06" version="1">MEKFREKLSSLRTEADNATARGDELENRVKSLENEGISKDHEIKSLEIRVKNLENELEVATANLAKVTTSYNDSKAYEENAERKVTALELESQDKEEKYESLLEKYNASKAELDELARQFDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PQD5</accession>
    <name>A0A162PQD5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type zinc finger transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_146929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD71946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289986.1">
        <property type="nucleotide sequence ID" value="XM_018431757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PQD5"/>
    <dbReference type="GeneID" id="28992663"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146929"/>
    <dbReference type="InParanoid" id="A0A162PQD5"/>
    <dbReference type="OrthoDB" id="3247418at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="31572" checksum="635F8D6C4145A018" modified="2016-07-06" version="1">MSNVCKSDIVSAHKYLENFCKECETLYTLDLISLNMHLHLHLQATICDFGPVYSYWLFSFERYNTSTITPYSQLSFSLANFITATLDVLISIKDNKPLLPTAFSLAKKPLSLIPTPEYNCLVDYYQVAYNNGMISSCKNDMTRQVYKGCNVNGRGFYIQALFEENRMNAHYGYIGEIQYIFVYLFIPTNSPTAPSNHNHEHIFAFVRWCKTTSDTRRQPKDIEIYHANFYNLDFQSILPIRCILLPVAIIDYKTRRSINRKIAIPLPQKIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PWT4</accession>
    <name>A0A162PWT4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_144241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292926.1">
        <property type="nucleotide sequence ID" value="XM_018431176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PWT4"/>
    <dbReference type="GeneID" id="28992082"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144241"/>
    <dbReference type="InParanoid" id="A0A162PWT4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="323" mass="37403" checksum="59F661F49547E66C" modified="2016-07-06" version="1">MSRNLNNNSVNNAFGEEPSVGSPPRNTNDIRTIMLQHSQGTVSNQRPLAPKRARLNLEGDSSGRTRNIHDVYEKLDTMNGVLNTVLKNTSSEKAEATASNAVEQDMSPGRQPTLDQLLRDYLSEEKLYDQYNTNENKNSEGNRLVLKSVTDYLRRQEEGKKVDLPTLRTKIVRHIGNRKLQEKKTGEKKQEENRRACLRQRRVKSCERRQSALKANRAHFVNSFGENVDSILHADYMSDLESDDEREEEEQDSSSEKSFFWRFRPSWRSEEGDRFVDELDADYEAAHDKKNNTRPFEHKFKGIRDKQLSKTKANKLPSWSKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q081</accession>
    <name>A0A162Q081_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_142961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294016.1">
        <property type="nucleotide sequence ID" value="XM_018430908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q081"/>
    <dbReference type="GeneID" id="28991814"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_142961"/>
    <dbReference type="InParanoid" id="A0A162Q081"/>
    <dbReference type="OrthoDB" id="2290077at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="327" mass="36825" checksum="2C5FCB91F11E6792" modified="2016-07-06" version="1">MSKITKAPRYQCRTCKAELLVNGEVSQTVSLPDQSQFTSAMIPNLAFGENINTSSSEDMDIIDSTEDDESMNVIDKIEGTTPSLVFDFSQPLPVPSNNDKKNLAFMHPHLGNKLLEYFSHIKADRYDICIRGCTQFNNENDTTCVKCREARYKNDQTSESDTRVPVRSIVQLPLARQLALCLTDNKIRTEVLYHHNYQPSKDGQKADVFDGHAYQFMKHLFSGENDIAILLSTDGFNPYNVPGSVTIVHATVLNLNPMIHYEKNRMIQIAMFPSCTGPSDIWSFLEPMLRDLCLLQTEGMEVKTPAMMIRAKVYVLMVTGNIPALAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q3G7</accession>
    <name>A0A162Q3G7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_162734</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297716.1">
        <property type="nucleotide sequence ID" value="XM_018434685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q3G7"/>
    <dbReference type="GeneID" id="28995591"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162734"/>
    <dbReference type="InParanoid" id="A0A162Q3G7"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="77"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD79676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="572" mass="63521" checksum="A89F2EE3C7978D3E" modified="2016-07-06" version="1">MSAMNTDISHQTNNPDHQNRNIPKGYSSETAAHTEPQSDGSNSDTDSVQSSTDNATVFGNGKSLPLEPEYTPLPKMQMLILTIILISEPMTSAILFPFIYFMIKDFHLSDDEMVIGSYAGWITSIFFIGQLFSAIPWGRCSDQHGRRPVLLTGLIGNAVSTFAFGLSKNLWWAIASRAICGIMNGNTAVARSMLAEITDETNRPFAFSIFGFCWGIGLIVGGFLCNPVEQFPSLFGDSEFFKYYPYLLPCIVSALFTLSGWIIGYFYLKESNPSVLARKYNDQKLKDDQKTPNVADEQTKLLGTSKQTFYDGGSPIKSNSLSIASEEEMVTAKAQGSSLSRITRQSYAAIVCYTHIRLWGFQCMAFEEVIPLFYSTPLSAGGLGMDPQEIAKIFAICGIQQTFSQFIVYPMLNRAYSTLTCARLALIVFVPIYMIFPELSPLKVWMFSHTENENMWQWAFYISFMVLLFIRYTGSTTSHVSYMVLVSNSADPEIIGTVNGVCQTALSLVRALAPALGGTLWAISLRPTNVFPFDQHLVYYLLALVSLIGLYQTYNVDNSISIGGKKPSLQHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q4Q7</accession>
    <name>A0A162Q4Q7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_59086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298086.1">
        <property type="nucleotide sequence ID" value="XM_018440431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q4Q7"/>
    <dbReference type="STRING" id="763407.A0A162Q4Q7"/>
    <dbReference type="GeneID" id="29001337"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_59086"/>
    <dbReference type="InParanoid" id="A0A162Q4Q7"/>
    <dbReference type="OrthoDB" id="2448307at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF2">
        <property type="entry name" value="TRP C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="353" mass="40789" checksum="A4AB125FD734B9A8" modified="2016-07-06" version="1">MYDIKRKLRERISEKIWGKWFIILAGVQLVITIPNLIATLIIFHPIGDLGSRQDQKGWVLDGYKAIRIQAETIWFILFEVWRFWLAFDGVVQGSSLTVFLAFGSTIFAIALGIMQIVEFEKAVGNLTVNIIPHIVMTTLLLILTVPTTYVTYKLYKNCDWIIYKKLGSDVNLHRMYHWVQCYVLAVKSNLFFQVLLIIFYAIYIMLFGPDAWIWAFSICAPILSAAFLLFGRKAIADEQHWMMITFLFYQMAIIVLNIIVLVWSIGYMKADIWYFLCAYAGCSVIMCLAIQIGWYKTKKDHTVLDRRIATNHFSETMSLDGWGKNDDMMYIDPDSSLITSNCLVNDEISIKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TAW0</accession>
    <name>A0A162TAW0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">INO80 complex subunit F domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_79914</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441009">
        <property type="protein sequence ID" value="OAD65603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283643.1">
        <property type="nucleotide sequence ID" value="XM_018443525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TAW0"/>
    <dbReference type="STRING" id="763407.A0A162TAW0"/>
    <dbReference type="GeneID" id="29004430"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_79914"/>
    <dbReference type="InParanoid" id="A0A162TAW0"/>
    <dbReference type="OrthoDB" id="285793at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003889">
        <property type="entry name" value="FYrich_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003888">
        <property type="entry name" value="FYrich_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056513">
        <property type="entry name" value="INO80F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040092">
        <property type="entry name" value="TBRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22715">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR BETA REGULATED GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22715:SF0">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR BETA REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05965">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05964">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24245">
        <property type="entry name" value="INO80F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00541">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51543">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51542">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit F" evidence="4">
        <location>
            <begin position="36"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD65603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="464" mass="52303" checksum="62D474E0A0FDE0EC" modified="2016-07-06" version="1">MASPPPLSPSLVPKQPKPAFSAPQSPEHAASGFSEEKYKKLKRKLREIMEINESMNRDYTRTKKKIRTLTFERNLLLDNIARMEGQSSEESNSDLSEISDFESESEDVLASTSSKSTRVARRVTIHKDKRDPSSVLSSPNLSPTRHRDLATVASAPPKRSKLSRIAVKTRRVQPIERDETGHPKLPQQIGVLTVLDLGKIVSDRDTFHNERYIFPVGYTVSRTYPSMSDPTSNTVITSTILDGGDGPRFHVVAADAPEPIIANSATGAWTVVVRKSNEIRNREHSNSASGPDYYGFKHPTIAKMIQDLPGAENLKHYVWQNFEEMEPRAAKGVMAAAEKKRGNLEQMGNANRRPPLMDGIHDDESMEDEQEDIPAIASSSDPLIMADAELAMADDDEFDEDEEFPARHHIQHQNQHQHHQHQHHHQHQPQHHQHHNPYQAQIPINNVNEDMDEEVDQLNASDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TBX8</accession>
    <name>A0A162TBX8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GDP-mannose transporter</fullName>
            <shortName evidence="9">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_75134</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285482.1">
        <property type="nucleotide sequence ID" value="XM_018443048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TBX8"/>
    <dbReference type="FunCoup" id="A0A162TBX8">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TBX8"/>
    <dbReference type="GeneID" id="29003954"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_75134"/>
    <dbReference type="InParanoid" id="A0A162TBX8"/>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD67442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="342" mass="37734" checksum="1D30845048F2170C" modified="2016-07-06" version="1">MYPSVAVQSFSLSGHYCFASILMTVTNKYVLSGFEFNMNFLLLSVQNIVTVTLLQSFKFFNLIKFRGFDKDEARKWMPIAASLVAMIYTGSKALQFLRIPIYTIFKNLTIILIAYGEVIWFGGAVTPIIMSSFGLMILSSVIAGWADISDTLSSIIDLDTTLIGYFWMATNCLSSAAFVLYMRKRIKLTNFKDFDTVYYNNLLSIPLLIVPSLIFEDWSSENLARNFPADVREQMVYAMIFSGVSAFVMSYASAWCVRTTSSTTYSMVGALNKLPLAASGILFFGDPATFGNVTAIIIGFVAGLVYSYGKTAGNNKPKGHQPQSFPMSASSQSAMDAAKAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TCE4</accession>
    <name>A0A162TCE4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_175529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441006">
        <property type="protein sequence ID" value="OAD66003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284043.1">
        <property type="nucleotide sequence ID" value="XM_018437517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TCE4"/>
    <dbReference type="GeneID" id="28998423"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175529"/>
    <dbReference type="InParanoid" id="A0A162TCE4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="30175" checksum="8E57F3A1F6307747" modified="2016-07-06" version="1">MPKTEVGVEKYLDIVPDVKLTLVLYGDSAYMVSKCLYSPFKGISLSVLLGIVIKWYKFKVVDNRMLQINFASNDPVLIAENEGKKRWNTNERIDHTDNVEVINYLRDYILSQPTAAGVWPGLVVEKIKNNYKYIYRTMNMTPAQVTAKNRKTRSNSRRIEGNPDEKAYERLIEKDMMSDGESDSEVISPGYKQRTLRVARPSWRSDELNRLLGIIDKIMQTNDELQVTAMSKPRMIGRLTSIKDTPVPRNLSAKIPAWAIQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TE77</accession>
    <name>A0A162TE77_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_79956</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441003">
        <property type="protein sequence ID" value="OAD66433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284473.1">
        <property type="nucleotide sequence ID" value="XM_018443531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TE77"/>
    <dbReference type="FunCoup" id="A0A162TE77">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TE77"/>
    <dbReference type="GeneID" id="29004436"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_79956"/>
    <dbReference type="InParanoid" id="A0A162TE77"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="94"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD66433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="681" mass="75218" checksum="AFA8DE2F54043526" modified="2016-07-06" version="1">MSIKSFSIEVAPAAPGESATRRSILSPSELMVTPALGVETLHDILQYSATHYRDRDGFGYRVLEDTIVEEKDVTKTVNGVEKTETKIWTYLQLSKYSYFTYGEALEIAKALGSGLSKIGMQKQDKLQISASTSVEWMMMAHAAFSQTITIVTAYDTLGAEGLQHAMNEAESATCFINGDQFPIIEQILPSCPTVKNIIYRGKVKQEDIKRIQKSGQIQYALSYEELLSLGQQNQLPPVKPKSEDICCIMYTSGSTGNPKGVVLSHKNVVAAVAGCCRMLQHLVEEGDRVLAYLPLAHVLEFLVESLCIFFGVTLGYGSIRTLTEVSVRNCRGDIQEFAPTILTGVPQVWETIRKSILTKVVQKGPRIEKIFHGALDLKDYMSGYGLPTGFLDKVVFNNVKKQLGGKLRYGLSGGAPLSAETQRFLSMSACPLLGGYGMTESCSMCAVMSPDQFAYGEVGAPVPCVEVKFVDVPEAGYLSTNLPRPQGEIWIRGPSITSGYFKQENTTRETLTPDGWLMTGDIGEWTDRGTLCIIDRKKNLVKMSNGEYIALEKLESVYKTSVIVENMCVCADSLYAKPIALVVPAEGALRALALKSGGIQIESWDELCENKDVRKLVHEVLLQQGKKGGLKGAELLFDIWVCKELWTPESGYLTPAQKLKRKEILTYYSKQLKEINTRQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TJJ0</accession>
    <name>A0A162TJJ0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphotyrosine protein phosphatase I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_172923</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD69092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287132.1">
        <property type="nucleotide sequence ID" value="XM_018436894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TJJ0"/>
    <dbReference type="FunCoup" id="A0A162TJJ0">
        <property type="interactions" value="279"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TJJ0"/>
    <dbReference type="GeneID" id="28997800"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172923"/>
    <dbReference type="InParanoid" id="A0A162TJJ0"/>
    <dbReference type="OrthoDB" id="3388at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16343">
        <property type="entry name" value="LMWPTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000105">
        <property type="entry name" value="Low molecular weight phosphotyrosine protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050438">
        <property type="entry name" value="LMW_PTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002115">
        <property type="entry name" value="Tyr_Pase_low_mol_wt_mml"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717:SF7">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00720">
        <property type="entry name" value="MAMMALPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphotyrosine protein phosphatase I" evidence="8">
        <location>
            <begin position="5"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR617867-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD69092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="157" mass="17257" checksum="C087F0F183582C2E" modified="2016-07-06" version="1">MSNQINVLFVCLGNICRSPMAEAVFAETVKQKQLSDHFGKIDSAGTAGYHVGSSPDKRSAATCRKHGVPINSEARKVNKGDFAQFDYILCMDESNLEDLQHAAPNGSKAVLKLFGEFDPKGERIIQDPYYGGSEGFEHNFKQVVRASEGFLKSLKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TJW2</accession>
    <name>A0A162TJW2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_172429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287212.1">
        <property type="nucleotide sequence ID" value="XM_018436800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TJW2"/>
    <dbReference type="STRING" id="763407.A0A162TJW2"/>
    <dbReference type="GeneID" id="28997706"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172429"/>
    <dbReference type="InParanoid" id="A0A162TJW2"/>
    <dbReference type="OrthoDB" id="2206543at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="469"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD69172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1193" mass="133209" checksum="86AD56936E378801" modified="2016-07-06" version="1">MIGSQKQVINSTGRPTPTALILSGLKADFKKLHNVLSCSRCQTTGKIVSNGSTSRTGSPQFKCKCGATFTASSMQSLINAVQHKIPEVRSASEPVVSPSVSILGHSISMADIHEIESDVAPVFPTVMPTLQDIWDRFQVYDERLSALEAVQKENIELRKALATANTTIARLTKENIDFSVGAAASKYATIAASVPVVSQADFPSLPASQTHHSTEPTKTFVSKTPRKRAPTARAIAAVVRGMTIKENADQGFQIVYVPNAIRLPISTQRQRLRKLKIDNARVLDLHYPDRKVMGMLVHNEYAPELKTILASYGVTTLDNFDPLDPVHLRDPALASLSLDDRATKAIHVHNDRMLRAIEFIRAPVKFAVARSFCSQGWISDDQLAEMTIPTILSYAPLTSLLFITETWLLSPHRYPTSWQQYHTYGQSVPNASRGCMGISLLVNPSFPYPISIVPSSSPYVLSCIVFDFLIHCIYLPPSLSDDDAISILYDLPLSSSSIPSSNTIFCGDFNSRMGSFLGDHAITSRGTSFLQWIQATGLTCWNELLAFGIPTFLSGGSGTSRSSVIDLFLSTSPLLNPSMQIRSDLSLGSDHKMVNLTFTPYVSPPPPPTNHPRLLWNLSKLAQPDTLKIYIDTASGSLDNLTEQFSAFLSSSSPPPVDSLCSAFAQAIYDALDTAVGRRTPRTMQKYWFWSVDLQEAMDLRERSYQRWRHSSGLQKAICWMRHQDACHAVRLSVQRRRRETWKEFCNKLATQDFAKTTATMKRIKSHRQTSPVFVDPGGPQVAANKMADHLQQIFSGQFLPARRPPDQTVMISSPIAIDESCPFTHLSVESAILKLPTRKAPGVDHLRAEMLHPIVKQVSPVLCLLFQLCWQWAKGTIDPSLLISRNCVSAINSMRALQSLGVNHTGLSRLLSIRLYRQFIRPQFEYGLAISCFNIKQVAVLEKAQNTCLRMIFGGHSTSSTSVFRHLGNLPSMRERILTLGFKFVYRAFWLPDEALFTLLRPVLTNPAHQWFKLLANPIWLSLSNRQNADSKACKHAIRSFLNQGLSLQRSQQILLSACRPSLGVDPILWLPMTNYERSRFIRWRMGWLPGRPQPCSCGLHTTSRHHVIECTGAAIRLHLYSTVQPNPIDYVLNMLPLKTPKNNKNNAFWIFTWPILCRIMLDIEQICLPGVDLADHAATDRGQLFLNWLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TLL5</accession>
    <name>A0A162TLL5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Histone-lysine N-methyltransferase, H3 lysine-79 specific</fullName>
            <ecNumber evidence="2 11">2.1.1.360</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">Histone H3-K79 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_11958</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60328"/>
            <dbReference type="Rhea" id="RHEA-COMP:15549"/>
            <dbReference type="Rhea" id="RHEA-COMP:15552"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.360"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.360" evidence="2 11"/>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286133.1">
        <property type="nucleotide sequence ID" value="XM_018428691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TLL5"/>
    <dbReference type="STRING" id="763407.A0A162TLL5"/>
    <dbReference type="GeneID" id="28989597"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_11958"/>
    <dbReference type="InParanoid" id="A0A162TLL5"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140956">
        <property type="term" value="F:histone H3K79 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000033">
        <property type="entry name" value="Histone-lysine N-methyltransferase, H3 lysine-79 specific"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030445">
        <property type="entry name" value="H3-K79_meTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451">
        <property type="entry name" value="HISTONE H3 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451:SF0">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51569">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DOT1" evidence="12">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU271113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD68093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="309" mass="35381" checksum="EBD003F9145B88BA" modified="2016-07-06" version="1" fragment="single">DTDEYNPITDLIRTADLIYECFLTPSQQKLLGDDQQGVMRNLTKHRNRRNGPGFVEAVEEFNRVIRELRSSGELRKNAKAMRHPNYDLTCHILYQIYSRTVAHQAEALNNYAAFSNNVYGEINSILVKEFIAKTHITSSSVFMDLGCGIGNVVLQVAAQTGCEAFGIEIMETPCKYAKRQLKEYASRMRAWGLPTGKIRFRHGDFLESGNDVHPTLKRADVLLVNNYAFDWETNHSLAQLFLDLKEGTKIISLKSFVPKNHKLNQRTFHLPESILRVEEFEYFSDAVSWTNNGGTYYIATVDRSRLEPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TV40</accession>
    <name>A0A162TV40_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_187725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289272.1">
        <property type="nucleotide sequence ID" value="XM_018439417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TV40"/>
    <dbReference type="FunCoup" id="A0A162TV40">
        <property type="interactions" value="390"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TV40"/>
    <dbReference type="GeneID" id="29000323"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_187725"/>
    <dbReference type="InParanoid" id="A0A162TV40"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12909">
        <property type="entry name" value="SPRY_RanBP9_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035782">
        <property type="entry name" value="SPRY_RanBP9/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="79"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="3">
        <location>
            <begin position="384"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD71232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="647" mass="73193" checksum="7078AA5F415BB42B" modified="2016-07-06" version="1">MSDLISQLLENHSLQRNATIIPHRINSRTSTQTSPHHSKKLPTYPSYLKNTVYAALVKEQYEHQKIKRDRTKTSGIISTFRFKESDDNPLDDMCLALPSSWNQLDKSFNIQIRKNSLDLFYTGPGENDRDAASVRSNYAIPPQCGVYYYEAKILSKGENGFIGIGFSSSGNDLDRLPGWDENSWGYHGDDGFCFSGSGSGVAYGPYFTTGDVIGCCMDFSNNTIFYTKNGTLLNTAFKDVKPAFKLYPNIGLRTPGEHVLTNFGEEPFVFDIDRYVADQKLKIWKEVTSEPHRMQAPNITSPKYKIIADPNSNETQDNQNGHKQIMEQLIIPYLMHQGYTQTAKSVIKSTEDVMRTSSASIHALPYDISNDGEVTSLYSDEIKKMEERHVIKAAVLDGNIDLAIRIIQQLFPNMIKDESQSSIVFELKCQKFIEMMKSYSEQINRANQTEEPLSHLLVSHKNEDSHMDEIDSKASLLKDYVCEDMEIDEDFEDRTHVPSKRANSGIIIDKAIGQGSGIESGSQAKSLSKIPCLEDLIQDIMRYGEKLQDEYRYTMTSEQRAKLTKIFALLAYNDPIESPLAYIMDKSNRDVLASKLNTALCVCQQQRATTSLESIYKQAILTNKELVWSGNAKSSLININQYLKSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U4K4</accession>
    <name>A0A162U4K4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_146487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290323.1">
        <property type="nucleotide sequence ID" value="XM_018431660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U4K4"/>
    <dbReference type="GeneID" id="28992566"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146487"/>
    <dbReference type="InParanoid" id="A0A162U4K4"/>
    <dbReference type="OrthoDB" id="2242631at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="683" mass="78736" checksum="C54B92E9FADBFBBF" modified="2016-07-06" version="1">MLASQLPFEITIHISNYLSTKDRIECSRVCQAWAIAFQESLWDSIVISDKTTLNNICHPGSAIYQTYRTNGCYVKSLDLGLRLFATDKQLHTLQNHFKNLQYLRTQCSSLSATDFGTNAPNWSMWGTLTKLEMNLGFIKTPHIKAKLLDILACLPRLEQLHIAQDYTSKTVQFTLRDFETLHASLPLLEHLTLDMESQLITTSDLKLVQKNITPATKLKSLVFTVNRSGHRWLYYFAIKYPNIDGLATISFDASEGIETTKAELMTLLGRRTPEIGLGLGPGSLFQKLDKIQTTICQQSSPLHFWIWKKIYSDYHLPLKHLHCAIEEVYDKSNVVKNTFEDCINPYSTSLETLFIQVYENAITTAPWAITDYLVDYRNLVYLRIYTSDAPILVDIILDRCVALKRLGVSTNWLSVGQSALSSLSTRLTLHGLRMLEVYNSTVCSKTFKYISIRCRELNYMCLDYTGVTGYVSINTGKLSIDMPYTHFKTLLLRHIRFTSSRDVKECDRNVNLMALSFKNNKDNNDDELATQGVQEIKKKPKKKLTVCLSSRFPFVSTKRKVVENIKSKKDSKVEDCGKSSWFYTTYSLNSYSLWESNVSRLNEKEVERAREYYDRYSSEIRFVQETTIGAGGNIEGTREKWKKDRFRGYAAIRCDRIDEYIINTNLRRDCSDWDYLYDELDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U5L2</accession>
    <name>A0A162U5L2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_71831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291662.1">
        <property type="nucleotide sequence ID" value="XM_018442547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U5L2"/>
    <dbReference type="GeneID" id="29003453"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71831"/>
    <dbReference type="InParanoid" id="A0A162U5L2"/>
    <dbReference type="OrthoDB" id="2271149at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="250" mass="29878" checksum="6A524646DD9C7EDD" modified="2016-07-06" version="1">MYSCSNVKRRLTKHFKKPVFKKRKGDFYFPKVRHFTVKLRISTKQVQLNSFLEAISQCIINNYKTNPKYKYEEKLTEKDKTLMKHTYKKIIERLVLKEETTMEDVLYNKAKDYSVEHEIKEIEKETGKANLMKALPESLTIMLMNLDGKNDFDSIDKVFQDISCNRRHQPEEYWYRESVFNYLNPFMDKDSIESFPTEQDLLQDMYGFINNSSSSTSFYNKNMRRALGSIDIMEQMVTDRSDLTFRYPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U5R4</accession>
    <name>A0A162U5R4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_169671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290583.1">
        <property type="nucleotide sequence ID" value="XM_018436128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U5R4"/>
    <dbReference type="GeneID" id="28997034"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169671"/>
    <dbReference type="InParanoid" id="A0A162U5R4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="125" mass="14792" checksum="C30CED9684B0F3BA" modified="2016-07-06" version="1">MYMYMILQSQPQLQLQRYQSKKIGMLAVCVTLRSLTEMWEAKRQAHNTHREGEIEEKECLVLEESLAWVLDLGEVAPTDSLLIKYQKVYQATDKRFCGILLSYPMNQTSRKQVYQDTTCYEQMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U602</accession>
    <name>A0A162U602_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_145183</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291752.1">
        <property type="nucleotide sequence ID" value="XM_018431383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U602"/>
    <dbReference type="STRING" id="763407.A0A162U602"/>
    <dbReference type="GeneID" id="28992289"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145183"/>
    <dbReference type="InParanoid" id="A0A162U602"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="404"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="253"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="256"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD73712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="633" mass="70489" checksum="8A3D1A6FA84D68D3" modified="2016-07-06" version="1">MSALKSGKPICTTGKNLAGLWRPSFVKVNHQLFVFGGGGNVTDNLHALDLYTMRWDAVQALKGKAPSKRYGHTATRWNDSIVIFGGCNEFQEYCNDVYIFNLHTLTWTSPEVSNIVPARYLHSAMAYDDKLFVYGGFAKSMECTYVLDELNVLDLQTMIWTKYQDVPPRYNHSATLIGQKMYIYGGKDEHGSTVSDLYMINLLVPPYTPHLVLSGEQSSTSSKMVLLKSQHFCDAVCGKLLVFGRYLSKNQETNHSSSGISGSSNSSNSSSSSSSSSSGSGSSSSGSSSSGNGIPEASYSLWMLDLDTLEWERQECNIHFEVGGWNYFTAFKEQMMPGTEDDDQSVATVNSLLFLGNTDTYRPQGYDHFRDALIINSETLGLYDIGPPCCLNQLSRLLTNPELSDFVIVVSGGQEIQVHQVILITRWPHFRNMYNSGMTEALERRLEIPEPYEVVMVLLKYLYSDRLDETESWDVLCQVLVVANMYLLSRLKKMCCEQLYRRHMSVESCGAIFEKAILTDEVGLKMLTLDFIFRNYGSVLKSSTLMHMPLLVHQEFLEAIPDEAVLDIGQMRASNTTKPIGGKASGLSKTYSTPSLAYSSSDNIYHTQTYTSVNIVRVSTDNPVGATDVIIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UBH7</accession>
    <name>A0A162UBH7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHF complex subunit HOOK-interacting protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_145302</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FHIP family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291873.1">
        <property type="nucleotide sequence ID" value="XM_018431412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UBH7"/>
    <dbReference type="STRING" id="763407.A0A162UBH7"/>
    <dbReference type="GeneID" id="28992318"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145302"/>
    <dbReference type="InParanoid" id="A0A162UBH7"/>
    <dbReference type="OrthoDB" id="5350595at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019384">
        <property type="entry name" value="FHIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045669">
        <property type="entry name" value="FHIP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705:SF11">
        <property type="entry name" value="FHIP FAMILY PROTEIN CG3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705">
        <property type="entry name" value="RAI16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19314">
        <property type="entry name" value="DUF5917"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10257">
        <property type="entry name" value="RAI16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHF complex subunit HOOK-interacting protein C-terminal" evidence="3">
        <location>
            <begin position="602"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="758"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="811"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD73833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="951" mass="107907" checksum="C5DBF8CC5FFC91C4" modified="2016-07-06" version="1">MDYFSKFKKRIVAPKVQPTSAMQLAKFHKCWDYVHNVLMMEQNAGKVHVDQTEIPENLRHMVDMLVDEEARQEDNTTGVCMEYLLKNGVLEYLVNVSEKVDSPADICGETIRMIASMIDLLDDRFLVHHAVHKPTIKLLRFCVLDDRQSDIYHEDLVDLMYIICSKIYGFPALLNIFFHDKQWLTTPQKSLHVRDSDSGTSDPKKPEYEFLLFTYLLRFVHREGRSGDFARTGLLFLMEMATEHLGDFILESDFASIMAAGLGALYSQLPRKLVVNDEDEINSSSASYLLGQDRHPRLENLSSAEQSNSKEFKLQLDSFLKLLEFCQDVLTRCPHREISVRLLQSVRSIFLENILYPSILECSDMDGSSVAVISYIDLILQTLQQDALAEVVVGFLMNEEDDIIESRLRENGIFLLAGLSLDNTKPSPYFTTAERFTLKDLIFTRLQSSSQSTVVATLKLLKTLIVKHCRYSLQLLAIEPDIDPKDHSEEKKKTSTWISHHIREMTLYFSLISAIDSRPKTLTLGYEEYLQDVEQSLESDCCYQSFTNKLPSQDTQGTSKSERRRSFKYGDWQGRVSHERQPIRNLYQSHNNVTRHRIKSADPLLQILLSLLSHFFTQSSELNLALTSVVAALASCPYRSLEGWISFRESDQTTADDVLDLDRDEMSDSSEERGSIHGQDIYAHFDNGLVDEDDEDDDRSIDYGVEKTTQLRTPVRFKSYPPIFTLLRTLTQQVDYYRSEIDGFDTLLEERWQGLLLGEPEIDPRPTPSTSLSTRRMQAKDQPPEAPTPSRSLSTFFGVSPGKRRPPPPTTSSSVPTINPSKSLSSSTTAAALAAIRTHDTPLAVSVIPAIVSNPLSHLAIHAAKTQNVRIQPLFPSNFVSEEPILDLDEEDIVAFAPQAHPSKPKRNDKSTEITLAMILNNVVILEEAIKELAAIMQVRRSLGIDAVRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UD82</accession>
    <name>A0A162UD82_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_166638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293432.1">
        <property type="nucleotide sequence ID" value="XM_018435451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UD82"/>
    <dbReference type="STRING" id="763407.A0A162UD82"/>
    <dbReference type="GeneID" id="28996357"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166638"/>
    <dbReference type="InParanoid" id="A0A162UD82"/>
    <dbReference type="OrthoDB" id="2290502at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="462" mass="50466" checksum="072247F8685B019A" modified="2016-07-06" version="1">MQPLGSHEEDSDMGLDHDEEETDSIATNPYPYTESSIASTDAEEQAYLRDIQQQVSTQPTSRSSSMRDSLGRSFESPVMQPTLSRSPSVRTRPPRRRSWQDKQAIPIRPPSVASVQSQATNNGQSVRRPSRSSAVTPAATPRMRPSSSASHAASNERRAQRIRVGRAEPFFEETFDASVNPWVQQPAGRRYRAQDGQESEDSIEDERRADSRAQQFAELAAAHATAHAASNANANSNSNANSKTNTNAVISNALSVKNTNTRLSAPLPEEETSFRLQSPRMESSASSSVTATVGMAGIQEGTSAGTGTGTGTGMGMATLHDMSKSSSRQYGSYRPMERIPEPHVTTVGLGPATRRALEALQKEIVALNGRIDERDHRTQRHPSTLSDSPGISGKKPVKESENSGGEGWEGWRWVLKAAAKHAALNIVVAFIFILILSRRSDSGLINYWQTIRWAIKNQKNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UFX2</accession>
    <name>A0A162UFX2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_144239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292923.1">
        <property type="nucleotide sequence ID" value="XM_018431175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UFX2"/>
    <dbReference type="GeneID" id="28992081"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144239"/>
    <dbReference type="InParanoid" id="A0A162UFX2"/>
    <dbReference type="OrthoDB" id="2276543at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="63" mass="7297" checksum="BE7BEA63FE14134A" modified="2016-07-06" version="1">MQVKIKNEFGILKERFYSLKSIPKAKCRWEDIEKAEVECLQKTGYSEESDVVDGSQNIDVNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162URV1</accession>
    <name>A0A162URV1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADPH--hemoprotein reductase</fullName>
            <ecNumber evidence="4">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_108753</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="4"/>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295463.1">
        <property type="nucleotide sequence ID" value="XM_018428064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162URV1"/>
    <dbReference type="STRING" id="763407.A0A162URV1"/>
    <dbReference type="GeneID" id="28988970"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_108753"/>
    <dbReference type="InParanoid" id="A0A162URV1"/>
    <dbReference type="OrthoDB" id="2282236at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfite reductase [NADPH] flavoprotein alpha-component-like FAD-binding" evidence="6">
        <location>
            <begin position="14"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidoreductase FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="142"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD77423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="300" mass="33596" checksum="EB0ABBA72D0259A3" modified="2016-07-06" version="1">MVSCFSSQLRKLAPDTADEFDQLITPNFSNSDPYPAFIKRHRTLLDLQKAYPLVNSLDLGQFLTAVGCIQPRRYSIASSPLAHPKEAHVVVGLVDDVVNGFHYYGLGSSYLYRSNGVSIRASLKSSKGVFELPSDPSVPIVMIAAGTGLAPFRGFLQERAAQRAQGVKTGSSILFFGCRHPEQDYIFSDELDQYERDGVLSRLYVSFSRNTSSRPTAVRYVQHQLLAHSSEIWNLVMPTTKKDSKPAHIYVCGGGAMSREVRRTFYTMATYFGETQDDQEAKLLIQSWIDSKRFNEDVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UTN5</accession>
    <name>A0A162UTN5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exportin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_141758</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295933.1">
        <property type="nucleotide sequence ID" value="XM_018430659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UTN5"/>
    <dbReference type="STRING" id="763407.A0A162UTN5"/>
    <dbReference type="GeneID" id="28991565"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141758"/>
    <dbReference type="InParanoid" id="A0A162UTN5"/>
    <dbReference type="OrthoDB" id="2215036at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001255">
        <property type="entry name" value="Exportin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="36"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD77893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1032" mass="118108" checksum="84E74BBFE2535E49" modified="2016-07-06" version="1">MSENLLINFNGPFDVGELDRTVDAFYNGNTAMRQHAQEILTQFQNHPNSWQLVDQILENSQSLYAKFIGLCILESFVVVRWNTLPLDQRLGIRNYIVKIIVDLSSDKPKDGPEKTFINKLNVVLVQILKKEWPQHWAGFIPEIIESSKTNLSLCENNMKILKLLSEEVFDFSGDHMTQTKMKKLKHQMVDEFGVVFTLCRQVLASKAASSSLALATLETLQRILSWIPMRFIFESDLIEALQSKLLEEKDQRNMALKCFTEIVGIEVSPRYHQKLTQIYESVMKVISQIIPFTSDIAVLYETADRYDQELVQDLALFLTTFLSKYSTLLESQSIKSMAVESHQYLLQLTRVPEREILKICLEYWGKMVYEISEQASRSTSITPLRMQHTLYAEILKELRSILIENMAQPDEILVVTDEQGDIECEFVKQSDLTALHKSMRQVFGLLTALDMNLTEQIICENLARLLNTDQWSWSNMYKLCWSVGAMSSSMDENVEERILVRFTQSLVNLLNASAHNKDQACVVASCILYLAEQYPRFLKSHWDFLVLVMGMILKYLHDPQVSVREMACDAFLKICQGCLRELSVVQPNGQPPMLESFVMDVQGITSDLDPGQVCIIYESIGHVVSAAPIDYQKQLIGPWMRLPNETYEAALQQFVTSPEALESPGTLKALLNILKINTSACSSVGPGYLIQLQFIIPRLIITYKSASDRIKIAPVQDGQVVRSLRRIKSEILQLVEKFMVASEKIEEDNNSLLSELLNVIMEDYDQSLAALREPGVLDVMTSVFEKMKNDLWPGLLEATYNTVFKPTLEMISQNFVDFPEHRHGFYRLLRVLNRKCLTELLTGPPATFQLFIDSILWGTKHTIRDVSQVALQTCLDLIHNVSQLEDEDQASDFYSAFYVRILREIISVLVDPDHMNGFNYQSQILATMLGLVQEGEIYTRLFDPSTVENPLMSNTEFLQEYAQQLLCEAFPLLQKDQIDVLVMGMFEYSGDLSRFQTDLRDFLIDIREVGEDTGQARQIQEQEAELELLQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UYE2</accession>
    <name>A0A162UYE2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_89883</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPPC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296832.1">
        <property type="nucleotide sequence ID" value="XM_018443738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UYE2"/>
    <dbReference type="STRING" id="763407.A0A162UYE2"/>
    <dbReference type="GeneID" id="29004643"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_89883"/>
    <dbReference type="InParanoid" id="A0A162UYE2"/>
    <dbReference type="OrthoDB" id="10250284at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010378">
        <property type="entry name" value="TRAPPC13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055428">
        <property type="entry name" value="TRAPPC13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055429">
        <property type="entry name" value="TRAPPC13_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055427">
        <property type="entry name" value="TRAPPC13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23643">
        <property type="entry name" value="TRAPPC13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23647">
        <property type="entry name" value="TRAPPC13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06159">
        <property type="entry name" value="TRAPPC13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 middle" evidence="4">
        <location>
            <begin position="117"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 C-terminal" evidence="3">
        <location>
            <begin position="259"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD78792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39831" checksum="AAC8DCCB0A0FB1A0" modified="2016-07-06" version="1" fragment="single">RDFGLSQILQLPSSFGNIYLGESFGTFVSVNNESEYAVHQVGVKIELQTSSQRFVLSDTTATPRTTLDPQTTYDATVTHEIKELGVHILVCSTHYTTPDGKKRHFRKFYKFQVSNPLAVKTKLNHHGEGRVFLEAQLQNVSAGPMYLERMRFEPSEHFDFNDLNGFYNSKGQLKEGASVFGDNFIHPQDVRQYLYLLTPRDKDNDRIARTTNALGKLDIVWRSAMGDTGRLQTSQLTRKPPLLEDIEIQPFWLTEGQVRVCLETPFQLGVRIRNYSGQNMKLVLSAIKTKMGSVLLSGLSSRQLGDLAPSCTTETQLEFFPLTPGLQRVTGLKVTDLITGYTKDIDHLCDVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V0T1</accession>
    <name>A0A162V0T1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_157187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297273.1">
        <property type="nucleotide sequence ID" value="XM_018433580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V0T1"/>
    <dbReference type="GeneID" id="28994486"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157187"/>
    <dbReference type="InParanoid" id="A0A162V0T1"/>
    <dbReference type="OrthoDB" id="10665293at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="153" mass="17682" checksum="DE68730BDC52DAB1" modified="2016-07-06" version="1">MYATSHTTQTPTVVENLHHHHHHQHIHNHQQDHHQNHHPSHDNHLHSEPTGVEINQSWTQAHEKNSLEVKAVIDPPFSISPKEPTVGWSNMNSSSETSLDYHGSSFGGQTHLDKRLLTDPRLEMAAPAWQQQVRPRRSPRPINRDESRPMRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V5K6</accession>
    <name>A0A162V5K6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_140153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298183.1">
        <property type="nucleotide sequence ID" value="XM_018430339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V5K6"/>
    <dbReference type="GeneID" id="28991245"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_140153"/>
    <dbReference type="InParanoid" id="A0A162V5K6"/>
    <dbReference type="OrthoDB" id="2247662at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="94" mass="10455" checksum="82A8175395EC2699" modified="2016-07-06" version="1">MQPTLRDFIQQLVSALIHPFDAKKSCSTQALTETANAALTQFEKTYVSFPDFVDPAEDHPTESIQFNSVNQPILPIYLPDLSVSRSTLPYLALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V6U2</accession>
    <name>A0A162V6U2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_161078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298473.1">
        <property type="nucleotide sequence ID" value="XM_018434340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V6U2"/>
    <dbReference type="GeneID" id="28995246"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161078"/>
    <dbReference type="InParanoid" id="A0A162V6U2"/>
    <dbReference type="OrthoDB" id="2272201at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="326" mass="36420" checksum="6D19C1F0E8EC97CC" modified="2016-07-06" version="1">MSLSSVSPFPIQQKKKSTLDDLEDLVKRLNVHIDTLDSHISKPSDELDPWATHVPTHYAALLDRLQVSCSCTHKRPPCSSNVVPAKDVPWLDPIEPFQDKKPEDPLRRQYAHWCTLLRCLPFLDSKAQEQVRTVGVHGMREILKYKGAGGFSNEVSYFDKHTTKIATPAAGEQEGNGDRRGEEEGYDSGRLRDSMCFPKNTTAKNNYSNSNHRVSERMMNEYPRSASSLMSKLNGSTTLSILHESDNTLYKMNLSNGLSRSGGLYRPNGSGGSGSLGSKMSPLTQSSVESLCVRKPTFKGWLKRKNNSTKRLSHSSTLDKLTGWFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V7V2</accession>
    <name>A0A162V7V2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_161270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298672.1">
        <property type="nucleotide sequence ID" value="XM_018434368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V7V2"/>
    <dbReference type="GeneID" id="28995274"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161270"/>
    <dbReference type="InParanoid" id="A0A162V7V2"/>
    <dbReference type="OrthoDB" id="2218000at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="220" mass="24880" checksum="83C0728CB340CEE8" modified="2016-07-06" version="1">MHRNFESIPVFGTGRISRMNTVEKISHFGAVNVDGLRNTVGKKYIDSNAKFDTTLYIQISGVLRLHLFIRSDEEISEAELQGSCIDPIMYYILQSTGKHLLSMTVFFKDALEMRSSKYMAAVQAIGKNLQIGEKDNLYLMVKLYSFETTKYLVQLSHSLSSLDSLKQILICSKDNCVGAQEGRAGRRYCSIDISDLNLNINIKKTTSWNKRTNGFLIQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XB39</accession>
    <name>A0A162XB39_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_95464</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291665.1">
        <property type="nucleotide sequence ID" value="XM_018443908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XB39"/>
    <dbReference type="STRING" id="763407.A0A162XB39"/>
    <dbReference type="GeneID" id="29004813"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_95464"/>
    <dbReference type="InParanoid" id="A0A162XB39"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF127">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G09820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="3"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD73625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="59" mass="7216" checksum="514B77DC680EBEAC" modified="2016-07-06" version="1" fragment="single">KQYVCEHTDCHRRFKRPEHLKRHQRIHTAERPFECTYPGCGRTFARSDNLTQHIKTHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XBT6</accession>
    <name>A0A162XBT6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_145255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291825.1">
        <property type="nucleotide sequence ID" value="XM_018431394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XBT6"/>
    <dbReference type="STRING" id="763407.A0A162XBT6"/>
    <dbReference type="GeneID" id="28992300"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145255"/>
    <dbReference type="InParanoid" id="A0A162XBT6"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD73785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="62699" checksum="AE16D69913549B4D" modified="2016-07-06" version="1">MASKIYEFDFDEYPYVVGIDFGTTFSGCSYVYNKDRLDEIVDITKWPKQGCAVYPKVPTVSLYDPESNELIAWGYDAIFKANKLNNKGVYVKKFKLLLDPSNSSSTTLPEVISDYLCELYSYIHSSFKNSLGVVYNPSKFRYCLTVPAMWDDKAKRVMREAAILAGIVRRSDHPDRLILTSEPEAAALYCESKFNQFNLTKGNRFMICDAGGGTVDLIVFEIDEMFGLRSLREVTKGSGSSCGSGFLDDRMREFLINRFGEHSESNKVVIEQLINQFVIATKPEFEDEDDEFFVIPAAHSLDKKTMSEIGVVDGRFQVTVDELREDIFEPVVKQVLSLISCQLSQSETRLDAIFLVGGFGQSKYLAKRVKDTFETQVESICVPSRGELAVVRGAVMYGINPNRITHRVLRRTYGLEVHCPFDESEDSIENKMVTSDGAVRCWGRFNVFATKGECIAVDSCVEREFFIFYPDNFVSDLFAYDEDCEPPRYTTDPGVRKVAAFTTKTPVLPGIKYQQKVYFTTSMYFGRTELRVEIDIKGNKFIFTSDFDSHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XH77</accession>
    <name>A0A162XH77_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_61092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292895.1">
        <property type="nucleotide sequence ID" value="XM_018440748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XH77"/>
    <dbReference type="GeneID" id="29001654"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61092"/>
    <dbReference type="InParanoid" id="A0A162XH77"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="136" mass="15766" checksum="8B61FB958FA61F0C" modified="2016-07-06" version="1">MKSPYFSSERWYMKPCKHMHLLHIHMSGFAFLSVLPANNVLPITISGEQFVNDNTMSIDDTTERTGHGYAIEAFEYAKNCLLTTRHNEQDLYQLMQYATEEEAEIIRAAYAAPIKAFQEIKAKYEAHFRTLNTQCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XIU9</accession>
    <name>A0A162XIU9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_167493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293215.1">
        <property type="nucleotide sequence ID" value="XM_018435650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XIU9"/>
    <dbReference type="GeneID" id="28996556"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167493"/>
    <dbReference type="InParanoid" id="A0A162XIU9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="142" mass="16476" checksum="B0B3090E07C7726A" modified="2016-07-06" version="1">MPETLEGRRNQDIKESPLRRDRGNSLGRGFCKVKKKTVGELFVDEQCKLKRRYGRRNGTHNKQLRVKKIRSLGRQGTFVKMLFVYCLSAVITPHSENGYIVKDKNIFFDSGKTVAKTCSRDYYIMINTRCVSNGKGQYLEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XQ73</accession>
    <name>A0A162XQ73_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nucleotide-binding protein-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_123400</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294145.1">
        <property type="nucleotide sequence ID" value="XM_018428926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XQ73"/>
    <dbReference type="STRING" id="763407.A0A162XQ73"/>
    <dbReference type="GeneID" id="28989832"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_123400"/>
    <dbReference type="InParanoid" id="A0A162XQ73"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000709">
        <property type="entry name" value="Iron-sulfur protein NUBPL isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD76105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="303" mass="32711" checksum="353E5F03018FDA18" modified="2016-07-06" version="1">MLARRFLSTSRTLFHENPLGLHRPAVKQPPTIPRAQRGLPKKMPIAGVKHVIAVSSGKGGVGKSTTAVNIALAAAGMKQKVGILDADIFGPSIPSLMNLSGEPNLTEKGDRLIPLQNYGVKCMSMGFLVDKEAPIVWRGLMVMKALQQLLHEVDWGRLDLLVIDMPPGTGDVQLTISQQVVVDGAVVISTPQDIALIDAVKGVNMFKKVNVPILGMVQNMSLFICPNCNHESHIFGHDGAARMAEKMEIPFLGEVPLHADICKLSDSGTPIVISQPDGQFAAHYKEIASRLLDQLSSNDPKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y1D0</accession>
    <name>A0A162Y1D0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_185645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295875.1">
        <property type="nucleotide sequence ID" value="XM_018439114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y1D0"/>
    <dbReference type="STRING" id="763407.A0A162Y1D0"/>
    <dbReference type="GeneID" id="29000020"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_185645"/>
    <dbReference type="InParanoid" id="A0A162Y1D0"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10229">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD77835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="62536" checksum="B53ABDD27DA64DE5" modified="2016-07-06" version="1">MTSSRPFNPNDYPVVIGIDFGTTFSGCSYSFVHNDEVVDIVKWPKQNNNVYPKTPTLNFYQGSSNQMAHWGNAARLEMLRPTARNSVLLKQYKLYLDENIAKDLPPLPNGLTIVDAIADYLHAFHEHVVSELRKGFARNYGQHQFRYCLTVPAMWSDRAKSTMREAAIKAGLIEENDHRDRLMLISEPEAAALYCEKKCEQYNLGHNDQFMICDAGGGTVDLIVFRIDERSGRKLKEWTKGHGQSCGSVFLDRRMRKLLKKKFKEYLSSIPASAFETMMDTFVDLIKPQFDGVEDQFISLPAAMNLESLNNPAIGLEDGTLCISAAELKQEVFEPVIKEVLALIEDQLMKAGSMQAIFLVGGFGSSNYLFDRVMEDFGSRVGLVAVPPRCELAVVRGAVYFGLNPRIVTTRIPRYWYGIDTTTSFEEGIDPPNYKIVRADGSVRCDNRFSVYVWRGRPLDIDNCMSKDFFAYYPHHTTCTLYAADTEEQPRYITSPGVRKVANFTIPMPELTGVMEGEKVDLSIKMYFGEVELRVEAVIRGKTYGTTCTFDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YCH5</accession>
    <name>A0A162YCH5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_93858</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297805.1">
        <property type="nucleotide sequence ID" value="XM_018443839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YCH5"/>
    <dbReference type="STRING" id="763407.A0A162YCH5"/>
    <dbReference type="GeneID" id="29004744"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_93858"/>
    <dbReference type="InParanoid" id="A0A162YCH5"/>
    <dbReference type="OrthoDB" id="414133at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050750">
        <property type="entry name" value="C5-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46098">
        <property type="entry name" value="TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46098:SF1">
        <property type="entry name" value="TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD79765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="161" mass="18604" checksum="D5F7AAFC47A7255F" modified="2016-07-06" version="1" fragment="single">PVRCIEFFCGIGGLHYALNIAKIRANVVEAFDVNEIANKVYLHNFKKNPSKKTIDRLTEKDIEKLDAGCWLVSPPCQPYTRGGKMQDIEDPRAKALVHLIDLLPKLSTPPKYIFVENVKNFEISQSREKLVRQLDIMDYEINECLLTPEQLGVPNHRMRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YFQ0</accession>
    <name>A0A162YFQ0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_105061</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298415.1">
        <property type="nucleotide sequence ID" value="XM_018427881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YFQ0"/>
    <dbReference type="FunCoup" id="A0A162YFQ0">
        <property type="interactions" value="307"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162YFQ0"/>
    <dbReference type="GeneID" id="28988787"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_105061"/>
    <dbReference type="InParanoid" id="A0A162YFQ0"/>
    <dbReference type="OrthoDB" id="20368at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041691">
        <property type="entry name" value="Atg6/beclin_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040455">
        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="BECLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768:SF4">
        <property type="entry name" value="BECLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04111">
        <property type="entry name" value="APG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17675">
        <property type="entry name" value="APG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atg6/beclin coiled-coil" evidence="5">
        <location>
            <begin position="68"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Atg6 BARA" evidence="4">
        <location>
            <begin position="199"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="126"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD80375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="387" mass="44916" checksum="725E0E4BDEB68347" modified="2016-07-06" version="1" fragment="single">SFVVLSRSQATPPNQTSTSGQPLLQPQTVPATDEKQWQTQRNNNLTHRLRVAKRLFDLMSSKSSVDHPMCHECTDMLLESLEKQLEDVGRERDYYIDFLKKVKDGKVSQDEEKELVKQVKDLVVQEEKVTDLLKEEEDKRDALAKQLAAMEEEMKELNKRDEAFWEKSNSYQLKLQSFQNQRDSINLKYDHDVKQYERLQKTVVYNDAFSISHDGPFGTINGFRLGRLGSHSVEWAEVNAAWGQTLLLLYTVANKLKFQFQTYRLVPMGSFSRVEKIDGDSVLSYELYGSGDFGINRMFLNRRFDHAMVAILNCLKQLTDFAEERDKSLRLPYRINKDKIGELSIRLQFNQEELWTKALKYMLTNMKWILAFASRTIVTADAPTPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZVS1</accession>
    <name>A0A162ZVS1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_172592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287381.1">
        <property type="nucleotide sequence ID" value="XM_018436831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZVS1"/>
    <dbReference type="GeneID" id="28997737"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172592"/>
    <dbReference type="InParanoid" id="A0A162ZVS1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="141" mass="15611" checksum="AAC637F7CF4D270C" modified="2016-07-06" version="1">MVLQVQAQKESEIKGGFTSSGCLTVGCSGSLIQKTIGCDEASKIENSIQKSNLIVGNLGIGTIFMSILIKRIVPMNFDIYERKHINQETLMVLNMVKLSLHLTVKHPELVKPPISKALCIENLIYYEKSIVLQSGLISPYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZXW1</accession>
    <name>A0A162ZXW1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_171770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287781.1">
        <property type="nucleotide sequence ID" value="XM_018436662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZXW1"/>
    <dbReference type="GeneID" id="28997568"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171770"/>
    <dbReference type="InParanoid" id="A0A162ZXW1"/>
    <dbReference type="OrthoDB" id="10269585at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="115" mass="12814" checksum="90BDC249D4528F0A" modified="2016-07-06" version="1">MRGRNQFIRGVVEKIFFCFGRVTVKTGFVYSSAWTLLGADQTVLGLLDADQTVLETIGCGPDGFGDYWVRTRRFWRLLGADQTVLETIGCGPDGFGTIGCGPDGFGDYWVRTRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AHF6</accession>
    <name>A0A163AHF6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_168860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably involved in translation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291551.1">
        <property type="nucleotide sequence ID" value="XM_018435950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AHF6"/>
    <dbReference type="FunCoup" id="A0A163AHF6">
        <property type="interactions" value="374"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163AHF6"/>
    <dbReference type="GeneID" id="28996856"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168860"/>
    <dbReference type="InParanoid" id="A0A163AHF6"/>
    <dbReference type="OrthoDB" id="10248435at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01160">
        <property type="entry name" value="SUI1_MOF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="4">
        <location>
            <begin position="31"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD73511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="113" mass="12648" checksum="67C43ACD7C646B5A" modified="2016-07-06" version="1">MADLEDLNKPFDPFAEVEEEQAGAVKQTNYLHLRIQQRNGRKTLTTLQGLPAEIDTKKLLKAVKKAFACNGTVVEDEEHGNIIQMQGDQRLKMAEFLIQEGIAAKADIKVHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ALI6</accession>
    <name>A0A163ALI6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_144778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292371.1">
        <property type="nucleotide sequence ID" value="XM_018431286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ALI6"/>
    <dbReference type="GeneID" id="28992192"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144778"/>
    <dbReference type="InParanoid" id="A0A163ALI6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="182" mass="19994" checksum="D5A16BB73FF1FB53" modified="2016-07-06" version="1">MVFAVVVAPIDTSTPEVAVDTAPEFQVAVTPMDHVLTLLAANNVSMQSLQENAKGVTDAITYLKNDLDLSNKTNEFLKNSVLQLMTENAEIKKSMTSQNSVMPSAVPADSSSSMDDDLDLGVKHHPLISQLINRYIKKPNFVSTDLLKVAENNNRSAWSMTGTYGNKYNKTLALALFKYLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ANK1</accession>
    <name>A0A163ANK1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_95092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292741.1">
        <property type="nucleotide sequence ID" value="XM_018443880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ANK1"/>
    <dbReference type="GeneID" id="29004785"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_95092"/>
    <dbReference type="InParanoid" id="A0A163ANK1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="66" mass="7192" checksum="A548651F99E87ADC" modified="2016-07-06" version="1" fragment="single">AYVCICVYLCVCVCVCVCCLCACVPACLSACMYKCAYVCICICVCLFIRACVRAYACFICFICTCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AUF7</accession>
    <name>A0A163AUF7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_9598</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293951.1">
        <property type="nucleotide sequence ID" value="XM_018443938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AUF7"/>
    <dbReference type="STRING" id="763407.A0A163AUF7"/>
    <dbReference type="GeneID" id="29004843"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_9598"/>
    <dbReference type="InParanoid" id="A0A163AUF7"/>
    <dbReference type="OrthoDB" id="274922at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038:SF16">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="11">
        <location>
            <begin position="20"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD75911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="89" mass="9990" checksum="BE8792073DD77F78" modified="2016-07-06" version="1" fragment="single">VTMSSWGSFSQTYVNPENLIAAEKQVDAFMGLYNRILETCQVKCVPTDYHEPDLNKGESKCIDRCVGKYVGFQKLIAQKMEENGPTPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AXD3</accession>
    <name>A0A163AXD3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ras-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_109808</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294481.1">
        <property type="nucleotide sequence ID" value="XM_018428137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AXD3"/>
    <dbReference type="FunCoup" id="A0A163AXD3">
        <property type="interactions" value="318"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163AXD3"/>
    <dbReference type="GeneID" id="28989043"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_109808"/>
    <dbReference type="InParanoid" id="A0A163AXD3"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="180"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD76441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="24641" checksum="4352BF8885804A84" modified="2016-07-06" version="1">MSKKASCVVREHKLVMVGGGGVGKSALTIQFIQSHFVDEYDPTIEDSYRKQCSIDSETALLDVLDTAGQEEYSAMREQYMRNGEGFLLVYSITSRMSFEEITTFHQQICRVKDRDYFPMVLVANKCDLEGDRQVSTKEGQDLAKSFGSRFIETSAKQRINVDEAFFEVVRDIRRFNQEQASRRAGNSGVSGGGVGVGGGTSKDQITAQKPAKQSGDKCCILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B954</accession>
    <name>A0A163B954_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Basic-leucine zipper transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_185387</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296951.1">
        <property type="nucleotide sequence ID" value="XM_018439068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B954"/>
    <dbReference type="STRING" id="763407.A0A163B954"/>
    <dbReference type="GeneID" id="28999974"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_185387"/>
    <dbReference type="InParanoid" id="A0A163B954"/>
    <dbReference type="OrthoDB" id="2257100at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12193">
        <property type="entry name" value="bZIP_GCN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="172"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="184"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD78911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="271" mass="30601" checksum="2AF84B168FEB6528" modified="2016-07-06" version="1">MTTLLFKEIQRKLATTQTWGLDSRALDEWLENDLHQSGIISRTLQDNQCSADTCIKKEDTYDNSVCTSVKEDNTHKNIKTENTTPATPAKIDNLQSLGSLDAKRKLLALRPDLLPLMRALSFIGQLQRNSDQRKSIGSNTSITTSLTKRSRSSPSLKNSDGSDDNRGTALLKRQRNTDAARRSRLRKMQKMDTLEAKVKELEFNNQQLKLQEAIMESKRNAAELKARQTRERVLALEAQLAESHQTLIRGFKKEDVDPISEADGQNYADKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BBJ5</accession>
    <name>A0A163BBJ5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_162529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297501.1">
        <property type="nucleotide sequence ID" value="XM_018434641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BBJ5"/>
    <dbReference type="GeneID" id="28995547"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162529"/>
    <dbReference type="InParanoid" id="A0A163BBJ5"/>
    <dbReference type="OrthoDB" id="5596236at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="145" mass="16912" checksum="F7251D2C15C7EA8F" modified="2016-07-06" version="1">MFVSLSNCAASKQSSIQWSCTILQDKLYIPLFFAYITVIISILCLFLRKYQNSNQPKILFRKFCLSFYINQPKAKECLGSNISSEFGLPNQNCFEDMAPLQFEHNLWNRDLAAVLKFWHILNRLKHGGLLHKYQHLVFLSTSPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163CWK8</accession>
    <name>A0A163CWK8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycoside hydrolase family 18 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_183944</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441005">
        <property type="protein sequence ID" value="OAD66130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284170.1">
        <property type="nucleotide sequence ID" value="XM_018438860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163CWK8"/>
    <dbReference type="STRING" id="763407.A0A163CWK8"/>
    <dbReference type="GeneID" id="28999766"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_183944"/>
    <dbReference type="InParanoid" id="A0A163CWK8"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007842135" evidence="9">
        <location>
            <begin position="22"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="28"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD66130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="396" mass="43451" checksum="8EEC540DB481C4EA" modified="2016-07-06" version="1">MRSSLLVGLFGLIYLTAVSLAASAYGSRHLSAYIVDWNIPKSIPWTKLDHVIYSFAIPNKDGKLGDFDANQLKKVVKDAHAHKKGVSLSIGGWSGSLYFSSLVRTSASREKFANNLVQAVKTYNVNGLDLDWEYPNNPDGVSCNEKNANDTPNYLKLIQLLRKKLDAAFPNEHKTISAAVSTTVFRDGNQNPYKKLASGWKNALDYVNIMAYDLAGPWNPKTSSNSPLYSKNGEESIDSSVKQWVAAGIPKNRIVVGVPFYGYTALTTSPATAKSGIKVAYKKGTQIKGDQYDSKGADPCKGAKSSYSGDVLWKTIASKGIVRSASGWKTVWDSTSQTYFSYAAKTKQFLTFDDPRSLRAKATYVQKNKLAGVMLWSLDMDDSKNSLLNSLQAVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DGY5</accession>
    <name>A0A163DGY5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_182152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289200.1">
        <property type="nucleotide sequence ID" value="XM_018438577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DGY5"/>
    <dbReference type="FunCoup" id="A0A163DGY5">
        <property type="interactions" value="642"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163DGY5"/>
    <dbReference type="GeneID" id="28999483"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_182152"/>
    <dbReference type="InParanoid" id="A0A163DGY5"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021861">
        <property type="entry name" value="THO_THOC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265:SF0">
        <property type="entry name" value="HPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265">
        <property type="entry name" value="THO COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11957">
        <property type="entry name" value="efThoc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="616" mass="70737" checksum="706513D773DB240A" modified="2016-07-06" version="1">MSKFADFRLHAQKAVSECIEAAAHHRHSSNTNTLPPQFVQSLVQTHIAPIGGSENTLNVVLVEGKADWRKSALELVFRRSLLNIMNKWPEAEKERFYQLSDCLDIALTSSESDYLDTVIPLTLIEELLDVHTIAGCEDFFDYVEKRKEHLIVNMVPGRGKGLVLLRMCNEMLRRLSQEKNMVFCGRILMFLANSLPLGERSGVNLRGDFNNEPIHCDKDEDVNADPTMTDEQKAFYKLFWSIRKYFSSPPTIFQGENFIELQRGAEAILERFQTIASQEKAMSGDSDIVETSGRKRKRMAGSSIDDPDDAEEMLKEINHDYQFPRLLSSRKLLELEMEDARFRRNVIVQFLILFQYLSGFTQTEKENTQQLLAARGATKQSLAQPPFSLEEEQNQWVINMRESLLNLLRLTKPHGELYTDIVLTILRHERNWIIWKASGCPAFEKPPINAEELKQIWQNKKPKMTRPSPPYRFLYGNVEMTQMYGKPHETLSEVMLSRRKMPEPILVLEKALLELNKNAATSSIEERFDLANGALFQATRLMCRSHAYLIPKVYQSKKEVYKVLWESNMNIDEKPGTDAKPTGPERGTGEPVTARHVEAEIQVLQNAKEILSKELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DT86</accession>
    <name>A0A163DT86_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_65872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291310.1">
        <property type="nucleotide sequence ID" value="XM_018441546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DT86"/>
    <dbReference type="GeneID" id="29002452"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65872"/>
    <dbReference type="InParanoid" id="A0A163DT86"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="375" mass="40402" checksum="29D9462601EFB586" modified="2016-07-06" version="1">MPRLSANLISSSNRTSNSHRYRYRNRNHITNRITNRNPNRGLVRRRRSSRRADAFVPLFPREVKRTVQDMYAADMSLGQEEREAPPRKKRAVNIVFTDCRSSLAGVRGLIETPSEVAERELAIKNAAAKALEAELAERVLAERELALEAAAADVFLVEEAAFVASRAEEIAEIAVELSEKAAQVAADNAELGVRLAVQAISRAEDAYVAARTRAAQSAAASDDAFHTALCAEQDTLAYIGASAPYSGSGAAYAIEMAQEAATRQKVAAITANAARVAFVATITVRERVSVAEAKASEAAQVAAAAKKMAEKADTKHAEVAEKAAIVAEIAAAATAAIPKAKNQEPRAKSQEPRAESREKRIRIKGRGRGRDGFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EIS3</accession>
    <name>A0A163EIS3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_62380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296900.1">
        <property type="nucleotide sequence ID" value="XM_018440963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EIS3"/>
    <dbReference type="GeneID" id="29001869"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_62380"/>
    <dbReference type="InParanoid" id="A0A163EIS3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="109" mass="12719" checksum="34B3D5AB7FDBC50D" modified="2016-07-06" version="1">MHTEYDSESIECKRNKGEEVLAKEIVIRDILHKNYGEVKTIWEDILKTVNDVDRGAGDVVLISIKKKYNALIKKFKERQSCVPKLFHLQMALSEKDRLMMELIDLIINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167J6S7</accession>
    <name>A0A167J6S7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_153552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441029">
        <property type="protein sequence ID" value="OAD65308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283348.1">
        <property type="nucleotide sequence ID" value="XM_018433185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167J6S7"/>
    <dbReference type="STRING" id="763407.A0A167J6S7"/>
    <dbReference type="GeneID" id="28994091"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153552"/>
    <dbReference type="InParanoid" id="A0A167J6S7"/>
    <dbReference type="OrthoDB" id="2399838at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="45073" checksum="99B41B9EFD3B3425" modified="2016-07-06" version="1">MLHSNATQLPVANRCIKQILESADKWCIDFTHKTCKSLVDSNKHFYLYTIVVRSNIKNKGVPVCFFVTNAELITILSKWLSRIKSNCSLHVKLVMIDCSPVKISTLEEVFGQSVQVLLCHWHIKRAWEMHIKKDVKITGATYESKHERDAVRVALNLLMYAKTKEAFDQQYKEFVSKFAGHEKSVAYFAMHWHAKCDLWLMAWRLDPRFHTNSLIESYHHILKAYYLGRLRNFWVDRLVYMLSQKLVLTHVEKAKKKKAFDVDHEDALCMIETVEDNLMYKCRSFTDNSVWYELLVKEEFLMMGLQYSLTKKLPIVQNPEVQVVERNEKSATAQNELHLLELDEVSESLFKKLEEWFWDGHNIPDFERLLVSNGRNRCCSSAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JBY7</accession>
    <name>A0A167JBY7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prolyl endopeptidase</fullName>
            <ecNumber evidence="6">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_153157</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Serine peptidase whose precise substrate specificity remains unclear. Does not cleave peptides after a arginine or lysine residue. Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex. May play a role in the regulation of synaptic vesicle exocytosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S9A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="6"/>
    <dbReference type="EMBL" id="KV441008">
        <property type="protein sequence ID" value="OAD65677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283717.1">
        <property type="nucleotide sequence ID" value="XM_018433082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JBY7"/>
    <dbReference type="STRING" id="763407.A0A167JBY7"/>
    <dbReference type="GeneID" id="28993988"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153157"/>
    <dbReference type="InParanoid" id="A0A167JBY7"/>
    <dbReference type="OrthoDB" id="248387at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.120">
        <property type="entry name" value="Prolyl oligopeptidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051543">
        <property type="entry name" value="Serine_Peptidase_S9A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11757:SF19">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11757">
        <property type="entry name" value="PROTEASE FAMILY S9A OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50993">
        <property type="entry name" value="Peptidase/esterase 'gauge' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S9A N-terminal" evidence="8">
        <location>
            <begin position="16"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9A N-terminal" evidence="8">
        <location>
            <begin position="202"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="7">
        <location>
            <begin position="473"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD65677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="694" mass="79076" checksum="79C9B9545DD1ABB5" modified="2016-07-06" version="1">MSILHILNIRVRTKTPPVPKAITDIQAHHGHNRNDCFSWMENIDNPATFGIIYPSGKQVLSQNRFLQRIVQREMKRRLQTRRQLPPLTTVAHGYEYFSTTSAYGMVYLRKPLGKGRDPPEEVLLHAGFLKAMNMSIRKILMSPDHSIFAYNTEREGMEYGELHFKDLNYRRDIGRCIQFRVGQQQDSLLHSYQCPTASTQRTTQEEDVLVFEEPDDSVFVDITSTKDMKFVTINSNSLSSSEVRVIDATLNVTQQNKPLLRLIKPRVPQLEYYVDHHDSTFYILTNAQKATNFKLVKAPDESVEHSEWEDVITMNPTEKIEDVDIFQPFQNNIVIYGRRDGLPIILCHDLSTKLTHQVDLPGRFCVVSPGTNLEFNTDTFRFSVSSPFAHESTYEYDVEKRKLNPVRVASIQGKYTTRFDKSKYTCTQIHVKSHDNQDIPVTLIHSKDYEKNSKNPVLMRSYGAYGVSTDPDFKIEHLPLLERGWVIALAHVRGGSELGRPWYEQGKLKHKMNSFRDFIAVAEHLVKTKVTSPDHLAAIGTSAGGLLVGSVLHMRPDLFRALVLRVPFVDPLSAMLNPDLPLTQVEYPEWGNPTKDKEAYECIQAYSPYENIKALSNATSLPAVFVTGGLKDQRVAYWQPLKFVAGLRHSLKESKDVLLKMDLDRGHFGGGSEQDARLSEAAEQVAFLISHVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JCD2</accession>
    <name>A0A167JCD2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_184080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441008">
        <property type="protein sequence ID" value="OAD65706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283746.1">
        <property type="nucleotide sequence ID" value="XM_018438878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JCD2"/>
    <dbReference type="STRING" id="763407.A0A167JCD2"/>
    <dbReference type="GeneID" id="28999784"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_184080"/>
    <dbReference type="InParanoid" id="A0A167JCD2"/>
    <dbReference type="OrthoDB" id="6278596at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012880">
        <property type="entry name" value="Gryzun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021773">
        <property type="entry name" value="TPC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374">
        <property type="entry name" value="FOIE GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11817">
        <property type="entry name" value="Foie-gras_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07919">
        <property type="entry name" value="Gryzun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 11" evidence="3">
        <location>
            <begin position="383"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Gryzun putative trafficking through Golgi" evidence="2">
        <location>
            <begin position="692"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD65706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1280" mass="143915" checksum="8D5C854FD6627F4A" modified="2016-07-06" version="1">MNTYPAEYLLHPVPVLAVYGLSADQTSTENEKIPTQKDSEESVAVISSSPQTRPSSGRQTPGNNALNLRSSLASTLHSLLHNKHDFTLYEATRYLHQNSANGAQGIPPFRVLSISKDYTLPTPSSSVHSPLSPLTPQSPLYPDGIMSPLWITKYLETPSVIVGFYELWDWSSEPGQGSKPVRETGPLGAHVMMDPTERENDVALAQEINDKRKYFQDKGIKFSAVILLKNRHTEDPSVEERLNLIRKQSGLDAKNSFFTVAPGSHHDLQEFVNTLYRCLYESALQYYSNVIKKLRKKKSKLPSPASSARPSMADLTSNEPQPLSSQGWQLRYDLKIAFFQELKQDIEAALKTCVVAYGLLGDVLAPTSSVTQGLVSLPARGKRWTEARALADCINIKICRFHLFLNDHTAAFSQLNGHLHLFQTYSSAWGMGEQSFEYWEWLSKQYRIFADVIDSAIQAGFKIPLPTAYLTNNGTANVPGSPLLGGSNNNLSSNSQVVGCNPGAIIQHPGFYYHLAAMCCAERRRRFLDIERSEAAKAAAANKESVAPSQLEVLLSKERQVDHSSLTIELLTKSYEQFKKYRNGRMTLYLAAEIAGTYYETGKFEMALKFFERIGKTYRKENWHMVLTSILRWSLRCAKELGSWERAVECLIELMAEELPMAKQKRADIQRELFDVLYHNEASNTIKHAPLTIAMDQINSFLKCSVQFLNQTSFVDTPELYQISLSTDKNSPVLPFRFNAMRVLFSEPQYNCYLEDAGLDEEMKKLDLIDFSKDMTKATTGDYVDWFTKKVDLRVTEHQTRVFQGQIISKDCDGIKIVGVCLDLISPQWNVALSYSFDKLSDDQTVTRRKWLEPSGDPSGRPKFRFISGRGELSAIKITQRPPRIQLSIHQFSPALLDEDFEMCVTVTSEETERIDVTLCMEIKNAEGQAGDYAWFKEAGDKSLESARTFVIGVIEPGQSVSTVVYIHGTGSVGPRLVNLKAEYVLSSASGKAHVPKVEKSESVTIPFVSPFETTFELCAQGEDQGKTVPFDLKRTEKWLMVAAIQCCSTWNLDIESVRLEQEAFEHPYTFLKLLSKMDNFKNQVWKTSHVYNANYLFRLSTMDLTEAMPSVPVGNIVVQWKRHGQEGAYSKTVLKAPALEFQQLSLVVIADIPSELYMGEPFTLTYTIHNPTINLAEYTASIELSDAFVFSGYKQLKGRVLPLSRASYQYTCYPLVAGKVRLPRLKVIAKQQGTEKEVPVELLAVGVVVTLDNALDQQVRQTTVEQQPTLVFVGAKRHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JHU2</accession>
    <name>A0A167JHU2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_98007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441006">
        <property type="protein sequence ID" value="OAD66007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284047.1">
        <property type="nucleotide sequence ID" value="XM_018444039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JHU2"/>
    <dbReference type="STRING" id="763407.A0A167JHU2"/>
    <dbReference type="GeneID" id="29004944"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_98007"/>
    <dbReference type="InParanoid" id="A0A167JHU2"/>
    <dbReference type="OrthoDB" id="430364at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="1">
        <location>
            <begin position="108"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="425" mass="48875" checksum="2C99E0CBEFBE7017" modified="2016-07-06" version="1" fragment="single">RKHLLQAPVLQVVYASTIKDRYLFLFSDLLLICKPIMDESIIVSSPINPDSESRSRFKSTESSLFQIKNIVELAQMTLFLSREDQPSFDNRHSMNNSPGATGSGMHPMLVTALRKFQTSAESGVAYLIDKNVLIQEPLSIAGFLFKTPDLSRRQLGYYLSDRNNNDIYEAFLNCFRLVGLRLDEALRILLTTFRLPSQWENIEYIIEQFAKKWHDANQNVIKFHEDMVVKVIVAMLFLNAEICVAFEPLHYITSVRTKGSRRPTVEDFLERWKYYDQYELVEAEFLEEMYRSIVAERLETGWDTRPGKTEEQETDIVITVDANQLPSRLTRNVPCLPIRISIPSPDPGLQIKLRGQDLLCQPNILDFSQSAVQSFTVTGHTLGRTSLMFIKSGFNAGRYVSPTLPRTKSIVVERLFMRYTFQIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JTB2</accession>
    <name>A0A167JTB2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_189228</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441001">
        <property type="protein sequence ID" value="OAD66667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284707.1">
        <property type="nucleotide sequence ID" value="XM_018439625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JTB2"/>
    <dbReference type="FunCoup" id="A0A167JTB2">
        <property type="interactions" value="162"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167JTB2"/>
    <dbReference type="GeneID" id="29000531"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_189228"/>
    <dbReference type="InParanoid" id="A0A167JTB2"/>
    <dbReference type="OrthoDB" id="250802at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2950:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF11">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="12"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD66667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="117" mass="12980" checksum="7AA249B10451299B" modified="2016-07-06" version="1">MAASSSQGINTLLDAEREAAKIVQKAKQYRVQCLKDARSQATKEIEELKTQKAAEYQAFVAQHSGQSDETLNQVNAETDAKITELQALYEEHKSDAVEKLLKAIVTVQAVPHQNIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K3C2</accession>
    <name>A0A167K3C2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_183676</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ARPC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441025">
        <property type="protein sequence ID" value="OAD67190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285230.1">
        <property type="nucleotide sequence ID" value="XM_018438809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K3C2"/>
    <dbReference type="FunCoup" id="A0A167K3C2">
        <property type="interactions" value="243"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167K3C2"/>
    <dbReference type="GeneID" id="28999715"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_183676"/>
    <dbReference type="InParanoid" id="A0A167K3C2"/>
    <dbReference type="OrthoDB" id="429520at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.190:FF:000003">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039096">
        <property type="entry name" value="p16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD67190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="155" mass="17351" checksum="28D5CEE5F6F02DE3" modified="2016-07-06" version="1">MSWRKIDIDQFDEDTYTQDEFLAEFESPLPAEQVNATIQSRTTDIRNLLTRGDQNAALTLALSDPPYGRHLGVAKGMATQAVLDVLTQFRATDITPVINSISQDEQDVLMKYLFAGMARPEVYNSSVLLTWHEKLTEVAGTGSIVRVMTDKRTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KGR9</accession>
    <name>A0A167KGR9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Brl1/Brr6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_160216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286097.1">
        <property type="nucleotide sequence ID" value="XM_018434140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KGR9"/>
    <dbReference type="GeneID" id="28995046"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160216"/>
    <dbReference type="InParanoid" id="A0A167KGR9"/>
    <dbReference type="OrthoDB" id="5961at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040202">
        <property type="entry name" value="Brl1/Brr6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018767">
        <property type="entry name" value="Brl1/Brr6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136:SF1">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10104">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Brl1/Brr6" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD68057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="82" mass="9505" checksum="FE26B89A9E1DBA76" modified="2016-07-06" version="1">MERDEREIARTKVSAETIAEIINSFMEPISYKALIFFTIFTIGSLVFSNITFGLFQKRHREDPGYQQHIQRITHSHTSKSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KU81</accession>
    <name>A0A167KU81_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Basic-leucine zipper transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_172744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286938.1">
        <property type="nucleotide sequence ID" value="XM_018436867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KU81"/>
    <dbReference type="STRING" id="763407.A0A167KU81"/>
    <dbReference type="GeneID" id="28997773"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172744"/>
    <dbReference type="InParanoid" id="A0A167KU81"/>
    <dbReference type="OrthoDB" id="2285533at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="6"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD68898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="119" mass="13845" checksum="F27E75E498345269" modified="2016-07-06" version="1">MLSTERKDKNRLAQAAFRARQANYSRQRDNALLKLEAKISSLEKSHQEAINRAHHAEQNYINLANELYNVQQQLSLSMIENEYWRSCLTDLQQSLEQPCAVPDYNPDFLIVDSLTEHPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KZD2</accession>
    <name>A0A167KZD2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">6-O-methylguanine-DNA methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_116629</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = S-methyl-L-cysteinyl-[protein] + a 2'-deoxyguanosine in DNA</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="3"/>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287259.1">
        <property type="nucleotide sequence ID" value="XM_018428532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KZD2"/>
    <dbReference type="STRING" id="763407.A0A167KZD2"/>
    <dbReference type="GeneID" id="28989438"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_116629"/>
    <dbReference type="InParanoid" id="A0A167KZD2"/>
    <dbReference type="OrthoDB" id="1907495at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815:SF13">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="12">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD69219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="97" mass="10431" checksum="342E6B4AD4643E52" modified="2016-07-06" version="1" fragment="single">VPKGQVTSYKSLSDSLKSGPRAVGQALRVNPFMPLPVPCHRVITSNLSIGGFAGGSGDSQLVCNKRSKLIKEGCLFEGDTFIANSDGKRQIFENFKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L1B6</accession>
    <name>A0A167L1B6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_116611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287406.1">
        <property type="nucleotide sequence ID" value="XM_018428530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L1B6"/>
    <dbReference type="STRING" id="763407.A0A167L1B6"/>
    <dbReference type="GeneID" id="28989436"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_116611"/>
    <dbReference type="InParanoid" id="A0A167L1B6"/>
    <dbReference type="OrthoDB" id="271164at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="1">
        <location>
            <begin position="16"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="90" mass="10179" checksum="ECCF4C5EF9BCAAE3" modified="2016-07-06" version="1">MKQSESLEIPKSGIRPYFEVTVEDPQKVGDAINAHIVYKVKTKTNSPVFRSPECVVARRYRDFLWLYNQLTLGNPGVVVPPVPEKHALGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L2K0</accession>
    <name>A0A167L2K0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trehalase</fullName>
            <ecNumber evidence="5">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_126862</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="5"/>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287486.1">
        <property type="nucleotide sequence ID" value="XM_018429131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L2K0"/>
    <dbReference type="FunCoup" id="A0A167L2K0">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167L2K0"/>
    <dbReference type="GeneID" id="28990037"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_126862"/>
    <dbReference type="InParanoid" id="A0A167L2K0"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011120">
        <property type="entry name" value="Trehalase_Ca-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF6">
        <property type="entry name" value="CYTOSOLIC NEUTRAL TREHALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07492">
        <property type="entry name" value="Trehalase_Ca-bi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neutral trehalase Ca2+ binding" evidence="7">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="760"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD69446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="789" mass="89480" checksum="5D1D6C584A54BD9F" modified="2016-07-06" version="1">MTISNDDLVDVHAPASTYYTTGDNSSTGTRLRTLTGRYSRSHADNSSRRRRASNDDKSKANRFLIDVKETQRILVEQEDTDGDFQITVNDLGPKSFAVGTADSGGYRTIEIRGTYMLSNLLQELALADDYGRKHIVLDEARLNENPVDRLSRMIRHNFWDGLTRRIDGQGLEIICNDPKNRQADHNPRIYIPFSEDEVFEYYSQVAATRPHLNLEVERLPENITPEYVKSINDRPGILALAMEKTVLNGQETLQGVPFVVPGGRFNEMYGWDSYFESLGLLIDERVDLAKGMVDNFVYEIKHYGKILNANRSYYLSRSQPPFLTDMALKVYAKLPSSTADENKLWLSQVLQAAIKEYTTVWTAQPRLDPKTMLSRFRPEGLGIPPETESSHFDHIIQPYATAAEMSLQDYMTGYNDGTLKEPALDEYFLHDRAVRESGHDTTYRYEKRCANLATIDLNSLLYKYETDIADALQDILDDNLVDFQGVAQHASDWAERARQRRERIDQYLWNEEAGLYYDYDTVIEEQSTYDTVTAYWAMWAKCASHEQAERLTAELHRFEAQGGLVSGTEESRGSISLDRPNRQWDFPFGWAPHQIMTWQAFENYDKVDVARRLAYRWLYTITKSFVDFNGVVPEKYDVVSLTHKVQVEYGNVGTDFKYVPREGFGWMNASYQLGLNLVNTQMRRALGTCTHPDLFFEKALKRQDVDESQVRRRQSSVAAAKAITQNGFSITAMTTFGGESSPFGGSGGFGGGLGGSSAFKTFTSPEADWSPNGSVSGVDSPLEASENED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LE46</accession>
    <name>A0A167LE46_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_171631</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288289.1">
        <property type="nucleotide sequence ID" value="XM_018436637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LE46"/>
    <dbReference type="FunCoup" id="A0A167LE46">
        <property type="interactions" value="499"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167LE46"/>
    <dbReference type="GeneID" id="28997543"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171631"/>
    <dbReference type="InParanoid" id="A0A167LE46"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000211">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD70249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="458" mass="49972" checksum="18869B840EA34F1E" modified="2016-07-06" version="1">MGKEKTHVNVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDKLKAERERGITIDIALWKFETPRYMVTVIDAPGHRDFIKNMITGTSQADCGVLIIAAGTGEFEAGISKDGQTREHALLAFTLGVRQLIVAINKMDTTKWSEARYNEIVKEVSSFIKKIGFNPKSVPFVPISGWHGDNMLEESVNMPWFKGWTKETKAGVKTGKTLLEAIDNIDPPVRPSDKPLRLPLQDVYKIGGIGTVPVGRVETGIIKAGMIVNFAPAGVVTEVKSVEMHHEQLAEGLPGDNVGFNVKNVSVKDIRRGNVCSDSKNDPAKEAGSFTAQVIVLNHPGQISAGYSPVLDCHTAHIACKFAELIEKIDRRSGKKMEDSPKFIKSGDSAIVKMIPSKPMCVEAYTDYPPLGRFAVRDMRQTVAVGVIKAVEKVDKTSKVTKAAAKAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LF50</accession>
    <name>A0A167LF50_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_60220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288357.1">
        <property type="nucleotide sequence ID" value="XM_018440613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LF50"/>
    <dbReference type="STRING" id="763407.A0A167LF50"/>
    <dbReference type="GeneID" id="29001519"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_60220"/>
    <dbReference type="InParanoid" id="A0A167LF50"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF19">
        <property type="entry name" value="MITOCHONDRIAL AMIDOXIME REDUCING COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="156"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="321" mass="36356" checksum="238ED2F7FF36FB67" modified="2016-07-06" version="1">MPATKSPTVCGITIYPIKSCGGISLKTCKVGPLGLENDRRFMFVEDSIKRFITQRVYPSLAFIHPLIDEARNLLTLTTEGQDSLELPLHPDTKNLKLYSVQLWKDDLMAYDVGEAASEWITTFLRRHADHDQVDKDLSERNVPGIMRMVVLDPSNGQYERPAHPQLPGVQSPFTDQSPVSMGFESSREDMNRNLLRRGVSNGQTIPMSRFRDNISIKDTISWEEDEWLVAKVGDVTYYIIEPLARCPLTCIDQETAKKDKWKDSSVLEHLKKTRQFENTPGNGYFCVHTAPLTAGTVSIGDGVKVLERIPVEYRKKILQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LQK4</accession>
    <name>A0A167LQK4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Basic-leucine zipper transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_170989</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288949.1">
        <property type="nucleotide sequence ID" value="XM_018436461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LQK4"/>
    <dbReference type="STRING" id="763407.A0A167LQK4"/>
    <dbReference type="GeneID" id="28997367"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170989"/>
    <dbReference type="InParanoid" id="A0A167LQK4"/>
    <dbReference type="OrthoDB" id="2257100at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12193">
        <property type="entry name" value="bZIP_GCN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050946">
        <property type="entry name" value="AP-1_TF_bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462">
        <property type="entry name" value="JUN TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462:SF35">
        <property type="entry name" value="TRANSCRIPTION FACTOR JRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="281"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="293"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD70909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="360" mass="39948" checksum="5200C53B6A3B1C0C" modified="2016-07-06" version="1">MKLDGFCSATSSLKTDASYFRNTPYPVDQQPTHPLYTRNMNNPSFTQNYNIYPDAEIINPDVNAMLDDWLTTDLAQSGFLHSPKPSPEIGSLNMYLGPPSVQQDIINNNNTDHGTNQTPKKEYDYEMDISSVSSPQQTSLLSYPAEPSNLTTITTTTTTTHTNPHTHTNPHTPTHTPTTTTTSTVAPSQFFTLKFVSPQPYQGVVEFDQRPDNRTRSVPAMFIPQQEIAEPSRPSTLSIVPSHTISASTPAFSANPRSRKQTTSSDSVDDEGSVVDDVAAKRQKNTDAARRSRLKKVMKMESLEKHVAELEQKNSTLMLRVAVLDTEKANLLAKEVAFQNRITTLEAQLAEAHRILASRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LXS2</accession>
    <name>A0A167LXS2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_170679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289349.1">
        <property type="nucleotide sequence ID" value="XM_018436407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LXS2"/>
    <dbReference type="GeneID" id="28997313"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170679"/>
    <dbReference type="InParanoid" id="A0A167LXS2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="126" mass="14396" checksum="EA771E27B370FBC5" modified="2016-07-06" version="1">MTFVVYTPQLSEEQTSQLNIGSFLLMNLILTPKQSQIPHQEHTPGSVARRNQCLIMESVLHLIVDRHKYLKSHSSLTVYDVWKACDITLPSWMPEPPTNPSSTLPAIYIHKLPRLVPNYRSASCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M4W9</accession>
    <name>A0A167M4W9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_134710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289849.1">
        <property type="nucleotide sequence ID" value="XM_018429667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M4W9"/>
    <dbReference type="FunCoup" id="A0A167M4W9">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167M4W9"/>
    <dbReference type="GeneID" id="28990573"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_134710"/>
    <dbReference type="InParanoid" id="A0A167M4W9"/>
    <dbReference type="OrthoDB" id="286637at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="207"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="277"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD71809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="334" mass="37171" checksum="20F4FA9F43896BFA" modified="2016-07-06" version="1">MSSSPPFGWQKQSNSNKDDSKKSIQMLMESFLKEHTAYDVLPVSYRLVVFDTSLLVKRALAALMQNGIVSAPLWSSKTQKFAGMLMVADFIKLIQYYYAHASDPDTLLELDTLQIQDLRDPGRHNGTLAPQQLLSMHPMASLHEACRLLAESRAHRVALLDRDESACGTEMIVSVITQYRLLKFIAVNFKQTDALKQSLADLKIGTYGSDVATATIDTPVIDIINTFAEMNISAIPIVDENGVVLNVYETVDVMSIAKSGLYNKLNIPVGEVISSRPTDYIGVHTCTMESTIHSIFNMIRKQRTYRLVIIDDESKLVGIVSLSDILGYLVGYKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MAZ9</accession>
    <name>A0A167MAZ9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_146524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290364.1">
        <property type="nucleotide sequence ID" value="XM_018431668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MAZ9"/>
    <dbReference type="GeneID" id="28992574"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146524"/>
    <dbReference type="InParanoid" id="A0A167MAZ9"/>
    <dbReference type="OrthoDB" id="2242133at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF72">
        <property type="entry name" value="IM:7136021-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="4"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="610" mass="70874" checksum="F60C88DB934A741A" modified="2016-07-06" version="1">MLASDLPCEILINIANLVSFKDKSPCSLTCKAWQAPFQEAMLNEIVIYDQKQLEEICDEFITNDIVYQKNGQYMRYLYLYGEFQASDEQLHILQQHFRNIKYLYVKQARISNFNFGATANWRLWDALVELQIVLDDVRIENAERKFLDIMSCLPRLKRLELIRHTWLPVRLRFTLEDFETLHEHLPQLKNLSLSTDLTVLSAVDMIHITDVSPAKGLVFFDIDSKTTDFRWLSYFARKYPALHTLRWATCNNEITLDEHQDEAVALFKAIPTGFQNLRIASIRSEECPKGEHLIFWRSFCPSNIPIKHLTCRPYLSKNTPEVFEEIIKTCMRSFSKTLESLSIKCRFIFNTPFTITNSFNHCPRLVYLRIGYCNTSIELDVLLELCASLTNLRLSRGRLLVSSTASKNVSMCKLRVVEIHRSTVSAETLDYISSRCKKLDDIQLKNTKVIGSIFQNTRSLFIDMSGTRFERFCFENVWFSTLEDDENGSSNLNLIVISHPTIDQQTTDTLNTIPSEKVSPKNTIEYTWLYSSYKKDNNNSWSSVNWRLSKGQANWARKYFRNFELKRTLAGTKYSFDSTVEITGENWKEHLFNGFTTLKCGYIANLDVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MJ10</accession>
    <name>A0A167MJ10_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_146283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291009.1">
        <property type="nucleotide sequence ID" value="XM_018431617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MJ10"/>
    <dbReference type="GeneID" id="28992523"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146283"/>
    <dbReference type="InParanoid" id="A0A167MJ10"/>
    <dbReference type="OrthoDB" id="2207820at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="56"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="138" mass="16067" checksum="481329739E5B77CF" modified="2016-07-06" version="1">MDYISNCVFVDEAAFHINLKRSMAARTTATLDAILPPEILNIQLHRPTMPFKKILGSNVLAYLERLNNHEEFKEDYIVMDNVPVHTSKVIKRYITSRDYGCIYLPSYSPEFNPIEEFWSIVKIKPKIESLVGKRDDFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MQ53</accession>
    <name>A0A167MQ53_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_113012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291549.1">
        <property type="nucleotide sequence ID" value="XM_018428320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MQ53"/>
    <dbReference type="FunCoup" id="A0A167MQ53">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167MQ53"/>
    <dbReference type="GeneID" id="28989226"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_113012"/>
    <dbReference type="InParanoid" id="A0A167MQ53"/>
    <dbReference type="OrthoDB" id="1929311at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032704">
        <property type="entry name" value="Cms1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030:SF0">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14617">
        <property type="entry name" value="CMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="180" mass="20424" checksum="86E06BD79D27A02E" modified="2016-07-06" version="1">MPDLTAVELEEKELPEKSFVDNQKFKHEHTLEALPNYIKFGVAGHKKLSKKPTELASPVALVLTHSAVRAVDLVRALKEFNETAKIAKLFAKHLKVEEQVIFLEKYPIHIGVGTPNRINTLLEQGHLKLDRLELVIVDTERNAKRFNILDNDAVRGDIFSFLGNYISPRMKEGKTKLGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MS09</accession>
    <name>A0A167MS09_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_97111</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291789.1">
        <property type="nucleotide sequence ID" value="XM_018443999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MS09"/>
    <dbReference type="STRING" id="763407.A0A167MS09"/>
    <dbReference type="GeneID" id="29004904"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_97111"/>
    <dbReference type="InParanoid" id="A0A167MS09"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF107">
        <property type="entry name" value="CHOLINE_CARNITINE ACYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007890417" description="Choline/carnitine acyltransferase domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="7">
        <location>
            <begin position="30"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD73749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="643" mass="72440" checksum="76A2D126A8EF5CAC" modified="2016-07-06" version="1" fragment="single">SSSPLFLLFPFCIFTMAPATYSFQDTLPRLPIPSLKNSCDLYLRTLVPLLTPQEYANTERIVTEFQTSELAQSLQQRLVDLDQKSPYNWLEDNFWLNKAYLEWREPVMVNSNWYILGQDDANHPKELLANNAKSVAPGEFTRFQIRRAAHMVLRGVHYKEIIDRQELPVEMMKGNKAQCMWQYSRIFGVTRVPLPHCDSVLQGDASKLRHIIVVVRDQLFNLEVYDQNGPKSVDALEKDLLNIVTYVQNLQQLDAAIPLLTSWDRDNWAVARNHLLTIDPSHRVNTQIIETSLFGLALDDYSHGDALSDRTRSMFCGNQGIGNGHNRWFDKSFLLIVDSSGKCGVSGEHSPADALTVSFTFDHMLMETCPGPFDPSVISKATTPATANLSAVNHLRWKSDAKLIQCLADAQIAADAVASKSDSDVLIFTEFGNDWVKKVGRVPPDAFYQMALQLAYFRTHNTVVPTYESGSTRKYLHGRTETIRSCSTDSKRFVEAFVNPSVDTKYELLQKAAVAHRDYTMIASDGYGCDRHLMALRILNADHQMLSKSGKFEDVPMHPIFKDPAYANSQTWLLSTSSLHAGVRLMGTGFGAVYPDGYGINYMPAPKLIKFGIESKRGAKSVSTKEFAENIRQALRDLRVLCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MWG7</accession>
    <name>A0A167MWG7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_71463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292309.1">
        <property type="nucleotide sequence ID" value="XM_018442474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MWG7"/>
    <dbReference type="GeneID" id="29003380"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71463"/>
    <dbReference type="InParanoid" id="A0A167MWG7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="103" mass="11762" checksum="F536ADCCC3030E2E" modified="2016-07-06" version="1">MVSIVAGYARPEEELQVDKDCESIVNNRLAKSGIHTFIVTSLSTFQTPKLSIMYRSIEDMLPSGSASLPRKLEEEETCLVIRISLDLFSNPQPWQRFSFKTYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NCF8</accession>
    <name>A0A167NCF8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_143911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293704.1">
        <property type="nucleotide sequence ID" value="XM_018431096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NCF8"/>
    <dbReference type="GeneID" id="28992002"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143911"/>
    <dbReference type="InParanoid" id="A0A167NCF8"/>
    <dbReference type="OrthoDB" id="2442555at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="28839" checksum="D98311A99179EF79" modified="2016-07-06" version="1">MPTSNNSLEFVMNKHCEMVSHSGSADQTQFSGIAFNREIVDEMHGEVALQSVTDVFVNHADMEWTRTSAGNPAVTNLLSLKSFLPTEVNEATTKTIVAQKPKTNLPEKVDPDSVPTAESIGRGSYQKYNQNQVNKLFSLVFSENQTAAATARETEINVWTAQNYVRLAREKIQADFDAATVETDESNGLETMEVEEFFENKPDATLEQARIAVMEEFSGLQITKSAIQKHLVKKCALTMKKLEKLPEKRDDVSTIEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NGL5</accession>
    <name>A0A167NGL5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_59384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293894.1">
        <property type="nucleotide sequence ID" value="XM_018440486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NGL5"/>
    <dbReference type="GeneID" id="29001392"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_59384"/>
    <dbReference type="InParanoid" id="A0A167NGL5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="122" mass="13535" checksum="CA5EE146FAE187FC" modified="2016-07-06" version="1">MSYDSDPVWNGVCALIVESRVEDSDTPYILVNELHLFLYPGRLFLTESTGLIPSTAKKLGYTEVRALHGCIGGSFLSFKSSCIRLAQILTLAMIGKETRQERSNESGAKFSFFYILSDTRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NIC2</accession>
    <name>A0A167NIC2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_59509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294019.1">
        <property type="nucleotide sequence ID" value="XM_018440512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NIC2"/>
    <dbReference type="STRING" id="763407.A0A167NIC2"/>
    <dbReference type="GeneID" id="29001418"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_59509"/>
    <dbReference type="InParanoid" id="A0A167NIC2"/>
    <dbReference type="OrthoDB" id="2389915at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="724" mass="80956" checksum="FADB5D6016549CF8" modified="2016-07-06" version="1">MYQACSPHLGNKLLEHFLDIKADGYDICIRDCMQFNNKKDIACVTCSEARYKNGQTSESDTRVPVRLIVQLPLARQLALCLADNKTRTEMLYYGQKADVFNGHVYQSMKHLFSGENNIAISLSMDGFNPYNVPGSVTIVHATVLNLNLMIHYEKNRMIQIAMLPGCTGPSDIWSFLEPILRDLCLLQTEGMEVKTPAMMIRAKVYVLMTTSNILALAKLACHVGHMSKNGCHICRVVGQTPKHGQYFRMLPGTQTCSLESFRNYNLASSEDRKGLNGQSSLASMETFSAPFFFALDEMHGLCHGISKQVWGLVRGKYGIKHPLCLSLATQREIGAAMVAAKSTIPTLLHGAWRDMTKNAGFFRAVDWADILLFVVPTLVAERVQDSVAQKALLGLVQICNLLMSWELSAEDQTSIRSNLVEWNLFLESLLSTADIDIGVCTINQYIIQHYPQMIDLYGPPRAYSTRSVERAIGEYSRSIKSNSQVSVNAGNIMIRLVQSRHVAELTTVANTKTPPANLLVYSAYTDGWPVTEGGDPVNAECEIEFWGPLKNLTIFDSFENRSHLSLLLKTFYDLKGEECSMLEPSIKTSHKAYLNGCVIDAAFNQSFTREACYVHVQLQVDMNSRRSCSYHPGYKHFFGKMVIFFQHVHNSKRWPLALITIYSVHLKNGLHITSVVKPKTIVIHASDIVELVGLVPSNVNGSHYIIWPSLKHGPKLTLDALSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NWQ9</accession>
    <name>A0A167NWQ9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_142284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294816.1">
        <property type="nucleotide sequence ID" value="XM_018430776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NWQ9"/>
    <dbReference type="GeneID" id="28991682"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_142284"/>
    <dbReference type="InParanoid" id="A0A167NWQ9"/>
    <dbReference type="OrthoDB" id="2271250at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="140" mass="16129" checksum="6AFA11F0D0AD09BB" modified="2016-07-06" version="1">MSLPLPLPISLPLLLPLRPLRPLRPLRPLLPLPLPLPLHPFQYAIWKLEKYTKRRSFMPEYDPKDKEYYNQYYKDGTYHDPANAPPLTKAQTAAKRSSSLRAIHRAPSLLSQRATTLFRKTSAASTPPRCSENYNQSAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P0N1</accession>
    <name>A0A167P0N1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sterol regulatory element-binding protein cleavage-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PHYBLDRAFT_77163</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum. Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Binds cholesterol via its SSD domain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat SCAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295059.1">
        <property type="nucleotide sequence ID" value="XM_018443231.1"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167P0N1"/>
    <dbReference type="GeneID" id="29004137"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_77163"/>
    <dbReference type="InParanoid" id="A0A167P0N1"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032936">
        <property type="term" value="C:SREBP-SCAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045540">
        <property type="term" value="P:regulation of cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030225">
        <property type="entry name" value="SCAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378:SF1">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="15 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="18" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="16" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 20" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="330"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="609"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="654"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="23">
        <location>
            <begin position="271"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="20">
        <location>
            <begin position="748"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="20">
        <location>
            <begin position="834"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="692"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="804"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="886"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1093"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1273"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1394"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1517"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="706"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="807"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="893"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1110"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1281"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1333"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1394"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1404"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1517"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1535"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1555"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="1574"/>
            <end position="1589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="OAD77019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1751" mass="193330" checksum="2D1549393C875CC2" modified="2016-07-06" version="1">MPLLAIAKLNSSLSVYFYRYGNLFVSRTLLLLFFSFSLITFFSLPVLLDVYDSARQSTLPTQSHDAQFWHFSPHVQFTNTTQQITTTTTTTTTTAPTTTSAVTTQQIRISLAHKKITKDLLLHALDIHNLLTTSFVTLDGQPSSLSNICLGRQGLCVIHSPVDYWPTRASLEDDPDWRATIDRQSHRVSDQTGLSLHPFSMFGNATLDKNGYLINADSIVLTVLLKHPNPHYASRIWDTLWQHTTQQLNLARLETNPINAPTVFTFELPYRYYVLAIIHLGLFLGVSNAFSTSTLIKSQYTFGLATIFMSIACHTTTVGIFRFFEIRFVAVPWYLCWLVVHVATLENAFLMANAVLSAGCDMQVKEKVCRGIQSVGVPMTTTLVAEMVILSIGTAMDHALIKEFCLFTKIVLLVDYVLQFTFFLAMLSIDIRRVELADLGDSQLSKRLRELLHVDPSIEQGPDFCPVQDTPDEQDSKSCAECKEFKTHRAVNALLLCLIILALAMFRSKGATNVSNSLSAVSLPSKEVGHLELVSAHFWQVVNPLQETQWLNTKPPYLIVLAKDAQDADQGRSTLASCVSHYEAKSVALQTVHKQQQLMRPPPSRLRGWVYGVAETVLLAVLQVNLPSLLLCMVLVAIIMWITPRLRDRWLLPFLETSFVHITLRSLSFLTYMLPWITTFLNQSIAQTLNFQNQQQQQQRQHDQNQNKNNNRNNGSTNRHNHQGAISNQAKFDSSTNHVGRVSVKTLSGQHVADVHRIAVNHQHNTLVSSGQDGRLVLWDTNKANWMARLDPVKKSRLNSLYYPSRPTAQTSSKFSQTNNRNLNSSGGISSAVVRSVEIDRANKWIATGAEDGVVRIWNALTGQLMHSLSAESQHVETMDNGIRKRHGAMSASTSTSTSTSTSTSTSTLVAVESQKNTGVNSRVVDRVLGIQWVGRSTATTNTTTMNKGEAQNRIVSVHKSGMLREWDVTLGECVQQTCTGHLKDITVLHCVESEPAYLAKPGITWLFTASKEGVVKCWQRDVRTNDEPWTCAYTIDGHHGQIVTCLATEFPVGGIGLLVTGSSEGAVIAWNFETGEWIGTLSAGGVKTKKKNQQHARDHPIGGPLLRFSKTTSSNTNNDNSYNNNNNYNTVSTHFSATTTTTTTINNNNNYSHGGIEENPQVKGILHSLEHRVQNNEPGDHRGPITHVVVTRYCEVENGHGQCRGCISCFGNGFMVASCSADETVHAWRLERVGGPNVSCTLCAKDYHKKQYKRTRKVSTCNTTTDQDLVGGGISPIPSPSSSLTTSMTMSTSTLTNTGTNHGTTVSAGRPRKPSTSQSLPVRRVHRHIRPSRSSAHQGATSDDRGDPLLDIEQLAGDVEANLETRFLGKIDQVSGRGLVFCNNNILAGVRQRTTPVTPKGQNNPNSSNKSYSSSGDGFGGDTSGQWEAWFAPLQYHDPPVFHDFGDSNSLGHTKTSMMMIPVETFVLDTDLDQQNDSVIAEATVSVSPSNNNNNNLSIGSIIGSLFGVINRRPKSSLSKQQNTHPWRQRRRPQLSNNGSGSNTRISSRRRKDSKQNFDSEDSNKNSHKNSNDDDYDEDDEDSLDDGEASEILPFSTVRHIVPMTKSGFVCDFGNFVKVVTILQKEGAMRHSNQGLDETLASVVPLTATKSDCICLGDSEDCCGGKEKVNGKCCGGKNKRRNRQAINKDSNSEEDEVNNNYRPPVIVSPPAKIDISSCQVRSIADCSFKAHCSKAADCRASVSKKSSYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PCN2</accession>
    <name>A0A167PCN2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E2F-associated phosphoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_157817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295714.1">
        <property type="nucleotide sequence ID" value="XM_018433687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PCN2"/>
    <dbReference type="STRING" id="763407.A0A167PCN2"/>
    <dbReference type="GeneID" id="28994593"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157817"/>
    <dbReference type="InParanoid" id="A0A167PCN2"/>
    <dbReference type="OrthoDB" id="122464at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019370">
        <property type="entry name" value="E2F-assoc_phosphoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15967">
        <property type="entry name" value="E2F-ASSOCIATED PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15967:SF0">
        <property type="entry name" value="E2F-ASSOCIATED PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10238">
        <property type="entry name" value="Eapp_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD77674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="25205" checksum="00374FC690C37374" modified="2016-07-06" version="1">MDTIMEDSSEKQPKETFYDDIYFDTDQEDESDWQSDPDDPSPGIGLLGMKKAIPKTTTTRPKIPKKQQRKIMTDEDLMYDPDLDDADEEWVAEKIKKAAPKDKTPEQATTDAILTCPMCFNPLCYSCQRHDLYPNQFRAMFVENCKVVKTERYRTKPVDKKRQKKGKNSKDISSSSAAADDDGDDGDDSSFFVVRCETCDTHVAMMDNDEVYHFFNAISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PFX8</accession>
    <name>A0A167PFX8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADP-ribosylation factor-like protein 6-interacting protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_164727</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ARL6IP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295877.1">
        <property type="nucleotide sequence ID" value="XM_018435067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PFX8"/>
    <dbReference type="STRING" id="763407.A0A167PFX8"/>
    <dbReference type="GeneID" id="28995973"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164727"/>
    <dbReference type="InParanoid" id="A0A167PFX8"/>
    <dbReference type="OrthoDB" id="48562at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019532">
        <property type="entry name" value="Nucl_RNA-splicing_assoc_SR-25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10500">
        <property type="entry name" value="SR-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD77837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="189" mass="21952" checksum="F3B8BA2BD2F1DBD9" modified="2016-07-06" version="1">MGSSSTSHHRSRSPTRKQRRRHSHGDEYRHSHKHKHRRNKSRSRSRSRSRSRSRSRSPTRRSQKVAPDNEKTKPEAEKIDVIAQLRELAQKHNNTASNNNNKKSRRKSGDGHSHLSRRTPMVPKTKEVYEKERSVINREYDPQTGRMRLVRATGEILESIVSRDQQYQINKAATIGDGIAYQAQIAKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PKS2</accession>
    <name>A0A167PKS2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_73581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD78136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296176.1">
        <property type="nucleotide sequence ID" value="XM_018442881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PKS2"/>
    <dbReference type="GeneID" id="29003787"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73581"/>
    <dbReference type="InParanoid" id="A0A167PKS2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="176" mass="19692" checksum="5A98E99FAB64C4E6" modified="2016-07-06" version="1">MSSTQHHCAACHMLAHSRSTYKQCLMNPKNISLHIPQKRTNVDEYPAESSQTAALRIRSEPVQDQNLDIETSTSISVSELTEFSLANETITEVLEAVMEEEIEETLSDEEVTGREEEVEEILTVNRGSISLHCSHCNGTDHSQIISRFCPNNNSSRARGSRNRGRDLNNIVQLPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PRX5</accession>
    <name>A0A167PRX5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_140509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296464.1">
        <property type="nucleotide sequence ID" value="XM_018430417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PRX5"/>
    <dbReference type="GeneID" id="28991323"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_140509"/>
    <dbReference type="InParanoid" id="A0A167PRX5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="114" mass="13111" checksum="26029C245A47FD17" modified="2016-07-06" version="1">MIRSPTQAVMTATPLNIDEGTFSISNRPIAGMVQSYNHMQPEVEYVLSSVMEEKACRHLSYKLHKEKSLPEKLAGRNRFSRRRTRKIRVISFSKCPAIPRNVELLKEKKVRVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q0H3</accession>
    <name>A0A167Q0H3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Pyruvate kinase</fullName>
            <ecNumber evidence="5 15">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHYBLDRAFT_157664</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="5 15"/>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296907.1">
        <property type="nucleotide sequence ID" value="XM_018433659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q0H3"/>
    <dbReference type="FunCoup" id="A0A167Q0H3">
        <property type="interactions" value="435"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167Q0H3"/>
    <dbReference type="GeneID" id="28994565"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157664"/>
    <dbReference type="InParanoid" id="A0A167Q0H3"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="16">
        <location>
            <begin position="28"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="17">
        <location>
            <begin position="388"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAD78867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="533" mass="58375" checksum="FF9FCA755044EC35" modified="2016-07-06" version="1">MTRAVPEVSSKVQWISEMDVDIEPTAGRKSSVIGTIGPNTNSVEMITELRNAGLNVVRMNFSHGSYEYHQSVIDNTRTSFELYPGRPVAIALDNKGPEIRTGNMRDGEEVPISAGHEMTFSTNEEFQDICDGEVMYIDYKNLTKVIEVGRIIYVDDGVLSFEVLEVEEDSLRVRAINNGKLCSHKGVNLPGTDVDLPALSEKDKADLEFGVKNKVDIVFASFVRRGQDVKDIREVLGEAGKRILVIAKIENHQGVANFDDILHEADGIMVARGDMGIEIPLERVFIAQKSMIAKCNLAGKPVICATQMLESMTYNPRPTRAEVSDVANAVLDGADCVMLSGETAKGKYPVEAVRTMHDICLLAESVVCYPAHFNELRSLTSLPTETTETVACAAVSAAHEQKAGAIIVLTTSGDSARLVSKYRPSVPIIVITRNAQTARQVHLYRGCFPFHYKKASATPVTQSHFLSPFGGNLSHLSPAETAPWQEDVDARIVWGMEQAIKYGLVQHGQSIVAIQGWKNGLGNTNTLRVIYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q1A0</accession>
    <name>A0A167Q1A0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_176899</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296936.1">
        <property type="nucleotide sequence ID" value="XM_018437830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q1A0"/>
    <dbReference type="STRING" id="763407.A0A167Q1A0"/>
    <dbReference type="GeneID" id="28998736"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176899"/>
    <dbReference type="InParanoid" id="A0A167Q1A0"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="16"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="166"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="206"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="248"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD78896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="352" mass="38691" checksum="A28DDC78E8FFCDF3" modified="2016-07-06" version="1">MRLNWKYNRASRKKLYGHTNHAVTCLQFDEDKVITGSDDHSVNVYDIKSGKLMRILNGHSGGVWALKYVGNTLVTGSTDRTVRIWDINAGVCRYIFQGHSSTVRCLTIIVPTPSISSTEEHSPQPSQPLIVSGSRDFTLKVWRLPDLDEPVIDTDQKESTYLLHTLSGHTQSVRALAAHGSTVVSGSYDHTVRVWDVEHGKAGHVLTGHTQKVYSVVIDPKRNHCISGSMDSSVRIWNLEDGTCVSILRGHSILVGLLGLSGDCLVSAAADSSLRVWSAETGECQYLLAGHKGAITAFQHDSQKIISGSEGGLKMWCTKTGTLLHELIDDISGLKIFFKEWVAKPHGHMLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q336</accession>
    <name>A0A167Q336_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_141036</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297019.1">
        <property type="nucleotide sequence ID" value="XM_018430510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q336"/>
    <dbReference type="STRING" id="763407.A0A167Q336"/>
    <dbReference type="GeneID" id="28991416"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141036"/>
    <dbReference type="InParanoid" id="A0A167Q336"/>
    <dbReference type="OrthoDB" id="2432613at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007891372" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="28"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD78979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="259" mass="27227" checksum="AF37464D92CEE5A1" modified="2016-07-06" version="1">MFPSKYSIGAALLAFCVVTNASLAPSVPEPGTVWQAGKEYEIIWEEDNIKPSISQAWTDFRIDLMTGDNDDQIVLDTIASNMSGVDSMSYKWVVPDVEPHANIYFLMFTNDKDEAAWTTRFAIVGPDNIQQKPENTLQPDGQNIPWGIGKLVDEEQTVASVSVVSAVGDAAISAAAAVPSVGGVVSENTSNMSIMPGSQTAPSASNVQATTTITSKAQSSQTSGDSAHTASNVSSASALSALANFTGLLVSLTVGMLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q5H4</accession>
    <name>A0A167Q5H4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Beta-catenin-like protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_176618</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297144.1">
        <property type="nucleotide sequence ID" value="XM_018437804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q5H4"/>
    <dbReference type="FunCoup" id="A0A167Q5H4">
        <property type="interactions" value="739"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167Q5H4"/>
    <dbReference type="GeneID" id="28998710"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176618"/>
    <dbReference type="InParanoid" id="A0A167Q5H4"/>
    <dbReference type="OrthoDB" id="1898821at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001136">
        <property type="entry name" value="Beta-catenin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039678">
        <property type="entry name" value="CTNNBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013180">
        <property type="entry name" value="CTNNBL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978:SF0">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1 NUCLEAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08216">
        <property type="entry name" value="CTNNBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01156">
        <property type="entry name" value="DUF1716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta-catenin-like protein 1 N-terminal" evidence="8">
        <location>
            <begin position="86"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="37"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="606"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD79104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="628" mass="71963" checksum="00356EC316DB97B0" modified="2016-07-06" version="1">MNIDDIFKIPAIPSGRNKRKMPDTPDIQFLDKYKEAAEAAEAAEEENAKASKKRNVTFEDEEEASAATFDEDIDDDDEGRFFGGGLTEEQSRLLDLVDQYDVDEPEALTSHNVKKMILKFEKAINKNQEQRVRYAEEPEKFMESEADLDEEIKSLLALTQAPHMYPELVKLGSVPSLMSLLSHENTDIVIDAIDLINELTDEDVGTSEDDLERPEDAATGIKTFVDALLENELLSLLVQNLERLDEKEETDRQGVFKILGILENLMALEPSLAERIALDTEFLSWTLKRLQTKVFDSNRGYASEILSILLQESRVVRLKLGELGGMDVLLRVLSVYKRKDPQDEDETEMVENFFNAICSMLNEPESKSAFLEGEGVELMLIMMKERTLARIRAVKVLNYALTGEEGRPNCIRFVDALGLKTMFPIFMGKGLKKLKKSHKVFVESEDEEHIMCIILSLLRNLSPDELQRARVIRKFIEDEYEKVDRLLEMKEYYEARDQRVLAEIEEDKKGLDEDELEELKEDFYLRRLEAGLFTLQRVCLLLAVLTAEDNGIKEQVLMLMKRKDEDMSSVFKILEEETALMADYVYLRKVAMGKIIHTSEIGELKEDPSEENLTAKDSVNNDKMDEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q637</accession>
    <name>A0A167Q637_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_58186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297177.1">
        <property type="nucleotide sequence ID" value="XM_018440274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q637"/>
    <dbReference type="GeneID" id="29001180"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_58186"/>
    <dbReference type="InParanoid" id="A0A167Q637"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007891441" evidence="2">
        <location>
            <begin position="19"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD79137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="133" mass="14240" checksum="FAF7D9737ACCA7D7" modified="2016-07-06" version="1">MRASIAIIGFFCLISVNSAPLSEPQVNNDILPESVPVLHAPIQLNNNEAHPSTNSYTLSPHIDLIGPAKAIEASESIARFLSSDGTTKSTLSKSAIFSTAFAAIAVALYLVLWPTKYWGYKVCLDDASDSSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QEJ4</accession>
    <name>A0A167QEJ4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_162644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297627.1">
        <property type="nucleotide sequence ID" value="XM_018434673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QEJ4"/>
    <dbReference type="GeneID" id="28995579"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162644"/>
    <dbReference type="InParanoid" id="A0A167QEJ4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="209" mass="24037" checksum="69A2D8B73EEB7863" modified="2016-07-06" version="1">MFVWCASFECVTNLVLPWHPQQAKLVWKFVWSLTAENEKQFSGERCVSSAFLGIWCLSTVYNAFKLLPDLSPPKKYFLTIFSLPLRIFNIQLILSVKARYSDIFVLTFSSLAIPTFAIGLLKSIDISMNMGLLLVRQVPAIMDLLAIQLYLNVLINICAINFKQNLIGGYESDILFGFFTIITVKPVVYFSQCNWLNEYWYISRAQNLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QW75</accession>
    <name>A0A167QW75_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_184267</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298410.1">
        <property type="nucleotide sequence ID" value="XM_018438907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QW75"/>
    <dbReference type="FunCoup" id="A0A167QW75">
        <property type="interactions" value="282"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QW75"/>
    <dbReference type="GeneID" id="28999813"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_184267"/>
    <dbReference type="InParanoid" id="A0A167QW75"/>
    <dbReference type="OrthoDB" id="2011998at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034431">
        <property type="term" value="F:bis(5'-adenosyl)-hexaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008486">
        <property type="term" value="F:diphosphoinositol-polyphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901911">
        <property type="term" value="P:adenosine 5'-(hexahydrogen pentaphosphate) catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901909">
        <property type="term" value="P:diadenosine hexaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901907">
        <property type="term" value="P:diadenosine pentaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071543">
        <property type="term" value="P:diphosphoinositol polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04666">
        <property type="entry name" value="NUDIX_DIPP2_like_Nudt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047198">
        <property type="entry name" value="DDP-like_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF0">
        <property type="entry name" value="DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="6">
        <location>
            <begin position="32"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD80370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="211" mass="24082" checksum="FB9A154CF30AFE52" modified="2016-07-06" version="1">MATMTAPPPEQRIEYTKKARHGHNQDMTDENNIRQVAGCLPIDHQAKRFLLISSRKNADAWVLPKGGWEINETKEQAALRETWEEAGVKGIIYKHIGVFADKTNKGKVKAHHWVYELEIQEVAKKFPERKKRERRWFTYEEALLAAQSPFIREAIRMSSLNPANSPEPSPRVSDESQPTLTGTPPPTIKAIPRSNTENRRSFGAKLRALFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QYL0</accession>
    <name>A0A167QYL0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_138038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298517.1">
        <property type="nucleotide sequence ID" value="XM_018429920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QYL0"/>
    <dbReference type="FunCoup" id="A0A167QYL0">
        <property type="interactions" value="326"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QYL0"/>
    <dbReference type="GeneID" id="28990826"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138038"/>
    <dbReference type="InParanoid" id="A0A167QYL0"/>
    <dbReference type="OrthoDB" id="102559at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF38">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="21"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="134" mass="15189" checksum="1F96A7B4DDAC39F8" modified="2016-07-06" version="1">MTSYIEPEDLKSIVKDSSLTPQKDYVIVDVRDLDYEGGHIPGAVNVPAHELMDKANTLVEEYKDVPLVIFHCALSQVRGPKSARIYNETKSLLKPESTQQVKILRGGFEGWHAKFKQDQSLLESYDPAVWQWAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R543</accession>
    <name>A0A167R543_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_61914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298907.1">
        <property type="nucleotide sequence ID" value="XM_018440873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R543"/>
    <dbReference type="STRING" id="763407.A0A167R543"/>
    <dbReference type="GeneID" id="29001779"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61914"/>
    <dbReference type="InParanoid" id="A0A167R543"/>
    <dbReference type="OrthoDB" id="3039677at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="117" mass="12883" checksum="3FCAC10703DAEC0F" modified="2016-07-06" version="1">MLTLNIDWFQPFDGQTHSSGAIYLSINNLPRSEHLKPENIILVGMMPGPKEASADSMNHYLESLVAKLIDLYSGVSMTDYRNTQITVCAVLMCIACDIPAARKTSGFTSHMSTCTCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N2J9</accession>
    <name>A0A162N2J9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_189619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441030">
        <property type="protein sequence ID" value="OAD65184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283224.1">
        <property type="nucleotide sequence ID" value="XM_018439687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N2J9"/>
    <dbReference type="STRING" id="763407.A0A162N2J9"/>
    <dbReference type="GeneID" id="29000593"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_189619"/>
    <dbReference type="InParanoid" id="A0A162N2J9"/>
    <dbReference type="OrthoDB" id="2289373at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="203" mass="22585" checksum="B7D08750C9C6DA9D" modified="2016-07-06" version="1" fragment="single">MNPSAENYPAAIIPAHDEDAMSVMTEEDLIASLSDNISFASSTPGQFVAPSPLRPLVANAATTVLSLSEKLRLELQQHVEAVSAAHAMNDEQAAELALNKVRRVKEMIDIEIACSQYLSPSVKVVEKSSRTGGLTLNRRDLPKFQLADDVIRSFPNEEVFHSVDHFLRTFQKVIESSLQDIELVWKRFLPLCLPHSDDGWVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N2T5</accession>
    <name>A0A162N2T5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_176304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441011">
        <property type="protein sequence ID" value="OAD65264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283304.1">
        <property type="nucleotide sequence ID" value="XM_018437728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N2T5"/>
    <dbReference type="GeneID" id="28998634"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176304"/>
    <dbReference type="InParanoid" id="A0A162N2T5"/>
    <dbReference type="OrthoDB" id="5598377at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="159" mass="18064" checksum="805607732E70CB23" modified="2016-07-06" version="1">MTDAATHFYEKQYSINPINDSSVGDLLSYVSSKQFLSEATQSSITLPLTFNSIWEAVNCHPHHHSPGPEGMPYEILSLLFREDGQIVLWHAPVVITLGHMSSYCREHVDSLLCLACSLNKNCPQKVLRQTLFHFRPFPPAEYALYGDPVFYVFRNCKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N615</accession>
    <name>A0A162N615_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_73144</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441005">
        <property type="protein sequence ID" value="OAD66134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284174.1">
        <property type="nucleotide sequence ID" value="XM_018442793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N615"/>
    <dbReference type="FunCoup" id="A0A162N615">
        <property type="interactions" value="388"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162N615"/>
    <dbReference type="GeneID" id="29003699"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73144"/>
    <dbReference type="InParanoid" id="A0A162N615"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000015">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000107">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="51"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD66134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="335" mass="37500" checksum="274B0887A1EBA405" modified="2016-07-06" version="1">MSTSSMNVDPKKAPEDEFMPWVEKYRPIYLNDIVGNENVVSRLKTISRNGNLTNLILTGLPGIGKTTSILCLAYELLGPACKDAVLELNASDERGIDVVRNRIKAFAQKKVTLPPGRHKVIILDEADSMTGGAQQALRRTMEIFSNTTRFVLACNQSNKIIEPIQSRCAIMRYSKLTDEQILHRLTEVCKKENVPFTDDGLSAIIFTADGDMRQAINNLQSTYYGFKYVNSENVFKICDQPHPVVIQQILKSCSTGDIIQADDLIHSLYDTGYASLDIITTIFRVVKDYNELSENIQLDFIKEIGITHMRIIQGHQSVLQLAGLVARLCRVATTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N799</accession>
    <name>A0A162N799_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450 CYP5203</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_119271</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441003">
        <property type="protein sequence ID" value="OAD66434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284474.1">
        <property type="nucleotide sequence ID" value="XM_018428676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N799"/>
    <dbReference type="STRING" id="763407.A0A162N799"/>
    <dbReference type="GeneID" id="28989582"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_119271"/>
    <dbReference type="InParanoid" id="A0A162N799"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11064">
        <property type="entry name" value="CYP86A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24296">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD66434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="423" mass="48787" checksum="39169A75BB482C4D" modified="2016-07-06" version="1" fragment="single">TIDPRNIEHILKNNFENYVKGPAFDEATQDLLGHGIFNSNGERWKYQRKTASHIFNVKNFKDQFTDVFLNGFKIMSEKIFDPAVKENHSVDFHDAMYRFTLDSFILLGFGVHLKTLSTKEKVPFATSFDECQRNAIRRLTNPAWRIGETVRHCLAPWKKTIPQHVETINSFASDVIKNRRDQVAKGEEHGDLLSRFMKCRNEKGNLLDDTELRDTVLNFVIAGRDTTAQSLSWTFYNLMQNPAIEEKLLEEIREHITDSMEDDPPAMYEAIKHMTYAHAVFHETLRLHPSVPNNQKYALNDDIWPDGTHIQKGDYVVWSPWAQGRCVSVWGEDAKIFKPERWITPEGDLRRESQGQWPAFHGGPRVCLGQNLATLQALIVIVFLLKRYKLSLVPGQEITYLVSLTLPMKNGMSVMVEKRQPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N7E4</accession>
    <name>A0A162N7E4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_147598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289878.1">
        <property type="nucleotide sequence ID" value="XM_018431908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N7E4"/>
    <dbReference type="GeneID" id="28992814"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_147598"/>
    <dbReference type="InParanoid" id="A0A162N7E4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="183" mass="20236" checksum="61D6ADD0787C8EF3" modified="2016-07-06" version="1">MDCEYESDRDLAFLNGLSFCKCNLLPLLDNLLCFNVVWISGAFTTFNCMAKGAARFAKRNAFFNVKQDSRRIDGTSPCSECKIHDHILVKFVSSESMQRFVLLMWCCGLEILFTLWITVLSDAKTNVPAISVGTLEQPEAENISAGNQTTVEACMANLANSECEAKASQVSRTLSEDSGIPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N846</accession>
    <name>A0A162N846_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_146969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD71988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290028.1">
        <property type="nucleotide sequence ID" value="XM_018431770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N846"/>
    <dbReference type="GeneID" id="28992676"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146969"/>
    <dbReference type="InParanoid" id="A0A162N846"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="101" mass="11544" checksum="D6A1D4044592DB83" modified="2016-07-06" version="1">MTNCRTNLPSRLTFWYQTPQHRQKPDMPTTHVTKLTLDVFGYWEQDFPRNLGGPLLSIETCHLVDSPLTSTPTSLVPPATAHCQTKPLKESTVWYPLPKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N8H3</accession>
    <name>A0A162N8H3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_137141</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441000">
        <property type="protein sequence ID" value="OAD66814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284854.1">
        <property type="nucleotide sequence ID" value="XM_018429839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N8H3"/>
    <dbReference type="FunCoup" id="A0A162N8H3">
        <property type="interactions" value="1269"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162N8H3"/>
    <dbReference type="GeneID" id="28990745"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_137141"/>
    <dbReference type="InParanoid" id="A0A162N8H3"/>
    <dbReference type="OrthoDB" id="2160351at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021966">
        <property type="entry name" value="SF3a60_bindingd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12108">
        <property type="entry name" value="SF3a60_bindingd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="9">
        <location>
            <begin position="374"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="313"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD66814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="469" mass="55610" checksum="134708E50FE49DF8" modified="2016-07-06" version="1">MNNVLERQRAAHEDIERLEQAIVDQFMQDAKTHRERLHAEHTMDTFLTRISEKSHRLYDLYEDQDGLRQSEINALSGSSEFSEFYERLKVIKEHHRKYPNETVEPPEMEFIYLNQRKDESDDDELEKMFSGEEGLGRYFDFNALHAQYINLKSVKKLDYLQYLSDFDNFAQLYPKSIKSSPEYKAYLDSMVAYLRSFFERAKPLFDVGELENRARKEFEEAWDEGRVSGWEWSTQEKPGEALFCQKQFTKQSVFDGHKNGKKHIKAQEKLDAGGPKTKEDQRKATAWKETLIIRYADALSDVREESKANVERKQALTDKERILEQEQEEVEIAEQESDEEDEDRIYNPLKLPLGWDGKPIPYWLYKLHGLGVEYPCEICGNYVYMGRKAFDKHFQEWRHAHGMRCLGIPNTRHFHEITKIDDAYTLYEKLKKEGVQEDFKAETMEEFEDTEGNVFNKKTYEELRRQGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NEU4</accession>
    <name>A0A162NEU4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_67009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286944.1">
        <property type="nucleotide sequence ID" value="XM_018441722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NEU4"/>
    <dbReference type="STRING" id="763407.A0A162NEU4"/>
    <dbReference type="GeneID" id="29002628"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_67009"/>
    <dbReference type="InParanoid" id="A0A162NEU4"/>
    <dbReference type="OrthoDB" id="18134at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061462">
        <property type="term" value="P:protein localization to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038060">
        <property type="entry name" value="C12orf66-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018544">
        <property type="entry name" value="KICS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31581">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN C12ORF66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31581:SF1">
        <property type="entry name" value="KICSTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09404">
        <property type="entry name" value="C12orf66_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160651">
        <property type="entry name" value="FLJ32549 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158548">
        <property type="entry name" value="FLJ32549 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="452" mass="51693" checksum="1B2EFC8771D05E5E" modified="2016-07-06" version="1">MDLCISNLKALGAFDYGAANKLVTRPIRIYPPLNTIFFKLITCETLYTQLSYMKPKWFTRKDTLLNSQYAHLADEITREISLIDSNPSITQERASVTLLLQSLSEFCRCRQLLISIYHSMATQTTPSGTEAMIQELLLLSNLCTESSLPDHLYILGLGVEKEINILLSLLRARTAIVNYAFQDACISLFVCKQDLSDWKSTCEEQDFLEKSPMHCEQSRDAASTWRLSIFGNTSEKQGKQKQGHVWPQTLRWQARYLDNLAAKMTLYFSTILISKESILTEDDPEKALWKGLQVDYHDHILVIPPVPPRICTFRRRFNAFSISLVYEVTSTPFHPQGYVCAGTPYEPPQGIHSFPFIYCHPKQAPKDHLPNIISIIQGCRHKLGDPKGSPVYFFDNRISSTYYFMRVDEHVVLVIIYLDKHLHREPTTSDFMTSLVTSLRGSSVIGELVRME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NHG6</accession>
    <name>A0A162NHG6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_148934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287784.1">
        <property type="nucleotide sequence ID" value="XM_018432182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NHG6"/>
    <dbReference type="GeneID" id="28993088"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148934"/>
    <dbReference type="InParanoid" id="A0A162NHG6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="209" mass="23495" checksum="6A7632EFED961EF4" modified="2016-07-06" version="1">MRVVKSNVPKEDVYQNDSIYSSCPHKPNTRLNVARNSALTGVSITATEVQVTVSPIEHILTLLIANNATIQSLESKLKTTSEEIAHLKARPEWSITGTFGDEYIKSLALAIVKYFRIYKCCKPVPKSPNAIHVIMKRPECRNILSVDVMSDDESNIDNKVQEFITAVDSFTVKRLKKNAKSLLKRIPDEKETSMPQNLAVTLSEWCFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NL43</accession>
    <name>A0A162NL43_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_186327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293258.1">
        <property type="nucleotide sequence ID" value="XM_018439223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NL43"/>
    <dbReference type="STRING" id="763407.A0A162NL43"/>
    <dbReference type="GeneID" id="29000129"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_186327"/>
    <dbReference type="InParanoid" id="A0A162NL43"/>
    <dbReference type="OrthoDB" id="276515at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF36">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="185"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD75218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="549" mass="62151" checksum="9B59F72FAFE0C8E4" modified="2016-07-06" version="1">MRVVTQTEQDNASRYAMKGWFIGMAQWAGVGLFVSGLAYSFFPWYRKTQTVNKFYIVMCFSLGGGAYKSDRYMVNFERRGRAAMLDESTRKRYDILYGGKDKEVEETKKVLETPSQTTAHITTDITTTTVTTVTIVTTVTTINPIIIQPHPVYKKILNNKIKSLFMILNRYVETSMASEKSLRFMTFNVRHDHGKESTLQAFAAPPEIAQEGGLDHEQPWSIRKWKIADTILLYSPDIVGIQEPVLHQVTDLESLLNDEYEWVGAGRNDGKEEGEYCAVFYKRERNSGKLGFALVVRGISDKITPTVPGSKGWDASHPRIVTQVEFKRNDGSQFTLLNAHFDHKGIEARKGAADFLLKHTKDIQKVVVLLGDFNSPEDDPAYLSLTGAHYEGRKDQNSTLNHLEDLNQKLASAFSRRTGRPVRTTENNITLPTHHVFRRGMLKHLTEQGQQNLDQDQEPVFLDARYELVTRLTDERAVGSLSGPFGFAETFTSFGVGIDAENAPLRLDYIMILKNSSKVKVKTFAVLPNQYDDNLYISDHRPVLATLAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PIT1</accession>
    <name>A0A162PIT1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rap-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_65858</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291297.1">
        <property type="nucleotide sequence ID" value="XM_018441545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PIT1"/>
    <dbReference type="STRING" id="763407.A0A162PIT1"/>
    <dbReference type="GeneID" id="29002451"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65858"/>
    <dbReference type="InParanoid" id="A0A162PIT1"/>
    <dbReference type="OrthoDB" id="2499658at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050989">
        <property type="entry name" value="Rap1_Ran_GAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711">
        <property type="entry name" value="RAP GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="413"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="631"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="675"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="740"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="337"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="632"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="675"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="744"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="801"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="823"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD73257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="923" mass="102496" checksum="AFC2D298FA746F81" modified="2016-07-06" version="1">MSCSATNNNTINGSGCTTKNPSTNGLLPFSLTSSSLSYLSITPSPPPLGNIYSTNHPPTIEECREWITEHCHQLVEALSPTTQPLARSQQEMTTLLHSVRILLDAMDQTNPVPKQELQKIQSRFDTLKTTTTEKLDSETMREMIMAIQDICQTPYQPTSFVTIRGDTLLSFTLEPPHIIANPLTAHDYTTLWPDQIDPKATWFRQHFVGKAYITLIGPMSSISGDQSLSLLQQQQPQQQQQQRKKSLNNSSNVPDETYGIISIVREMAKEFAGLGNKSASILGAQFRIILRGGKTFTTSQHIVHEKLAKDTQTHLESIGAGHTLDSINTEQKKSRSLRNLSSSPNTNSNTSSSSSSSSSSSSSSGSFGNLNSTIQANRLMRAAILSVCPDLDLRLFKELSAESTSSMKLEDDLLRFDEIGIPKRYKFGVLNVCDGQTTEEEWFSNTGLSEPLEEFLDLLGTRVALLEYDGYTAGLDIKTGESGDTSYVSRWREHDIMFHVAPLMPLRKNDKQQVHRKRYIGNDVACVVFVEGNQAFDPTSIRSQFLHIFVLVHPEIAFGKPCWRVQVIRKHNVVEFGPMLPSPPLFFDKEELAGFITLKLINGENAALKSEKFSVPNTKARTGILKTLVDSGISTPTHVPPQSSNNNNNNNNFHHHLSRTPKDDSVFLAKYVQRNSHEAYERPKPPHIERSSTMVPSDSSNLWKLQMVERTFSGRVSPTPPQPSPSRSSLFQELKSLGKRRNHNNNTNNNNIINNNNNNTGSSKETTTTTTTTTTESSPVTKKEGQPKSVPRHSKSSLTEGVDKKVNSKETASHELRPRQASRRTTATATTTIASQSTPPKSVLQASQPNIISTILSRTPPNHNQSAHVKSHHEVSSVANVIEHPPGRQSRPISLTESLASTPLYTASRKLFNMFFFVYVKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PJT7</accession>
    <name>A0A162PJT7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_168881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291577.1">
        <property type="nucleotide sequence ID" value="XM_018435957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PJT7"/>
    <dbReference type="STRING" id="763407.A0A162PJT7"/>
    <dbReference type="GeneID" id="28996863"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168881"/>
    <dbReference type="InParanoid" id="A0A162PJT7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="69779" checksum="5786E5F0EC661276" modified="2016-07-06" version="1">MFPSTQIHTLDCHCIKCHNSHQKSSYAAKRTETRRNKRARVEAAMRNMDVDTEVIPTSRSDSVEAMDGQANSPFLDAASMFDNDRDDNDFDDNVEDEVNEIEIEDFNSEDPFAAPDMPKNEVHQFIAIFTVLFASRHVVDKGAAVLIEFINNLLRIYDQDFQLPTSLAGLQKMTGFSAITKGIKKFVVCQDCHTVYQDIVSAPPRCVSSKLGARSACNCNLMKSISSGALVAKREYVYQSIKNTLSVFFRCPSFEAKILCFDEENCRDNGTAQRLHHTDNQNWKGLQLHESRRVEIMGSGLFFCLVAWYSPPLQFKNWMYFVDACQYYIKPSITFDEITTTHSLLEKFCNACNIDYTATILTCNMHLHLHLHECICDFGLVYGYWLFGFEQYNGILKNFKINGKDGFEATYMKNFVQNAYKDDYINAVLKSSSQIPFIHTLSKLVTTSIPAATVTTLSSCPFRLQEFVQGYTDSYNPPKGNEPLPPFTFPLKYKKPSAKFVGSNGNIILGFAGQIQYLFTHSFQLPPTHNLHLTRMVHDHQQVFAFIKWFHTSSDRLREDDSVEFCLPTFSPDSYHSIISVYHILLEVATATIATSRNVSKMLVIPLPKKLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PL43</accession>
    <name>A0A162PL43_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_73608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287966.1">
        <property type="nucleotide sequence ID" value="XM_018442887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PL43"/>
    <dbReference type="GeneID" id="29003793"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73608"/>
    <dbReference type="InParanoid" id="A0A162PL43"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012023255" evidence="2">
        <location>
            <begin position="16"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD69926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="158" mass="18901" checksum="E2D23C847AE50213" modified="2016-07-06" version="1">MYWIRLFCVSAGVCAEWYPLMYHIHLFTTKTDNFLCIPIRQLVEKFSSSTPNDLHQCLFPCHNCGGSISMKNNIRLYKYNFLKTSILSSTIVVTIWFFEFKTLELQMYFRTLIKVLLLNFLKPPHIVYFFLREDKPFQFEKEYDTETPLSSFDNNYPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PSF5</accession>
    <name>A0A162PSF5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_64469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293597.1">
        <property type="nucleotide sequence ID" value="XM_018441306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PSF5"/>
    <dbReference type="STRING" id="763407.A0A162PSF5"/>
    <dbReference type="GeneID" id="29002212"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64469"/>
    <dbReference type="InParanoid" id="A0A162PSF5"/>
    <dbReference type="OrthoDB" id="2281940at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="430" mass="48586" checksum="2978B8A31F0CAD42" modified="2016-07-06" version="1">MTSTAFLGLDEIHLLGHGTGQQLYVALGGKFCPTINDGRRNAHVIHLQDWLKHHGYPFALDVSLEDIDKAICVSRADIPADFMGMWRSLKESNSKRKAVDWIDFLLSVVPTIVIDHFVFDHTKAAVMNLVTACRIAQQWRITAANIQEAEETIGCWHAFLHCEIEEKRLKPTIFVMNQHMLVHLGYMMRKMGPLQAYSCRPIERTIGVYSAAIKSRKKPGKNIENLLLRKAAINHSLGCQPVICATNDRRTSNFEVASNDVAGPQLWSRPTRSSLAELAATIGIECQDLVHSLVPFWAREDIVSFEENDEVVCANKMWKDLVVYRVRFSVDSRHGRVNNLAVLNDAKEYGFILKFFSQTVNRVTRLFVAIDCLSNFQCVNQDLFPAWDSLASGVVKVVNVKSIEGIAGLVHNPNNKVIRHIIWPLPKYNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PV64</accession>
    <name>A0A162PV64_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_144773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292366.1">
        <property type="nucleotide sequence ID" value="XM_018431281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PV64"/>
    <dbReference type="GeneID" id="28992187"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144773"/>
    <dbReference type="InParanoid" id="A0A162PV64"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="179" mass="19745" checksum="7AB06628446DD8F7" modified="2016-07-06" version="1">MHPLHNAILPKLLSTIKHGYEHDEPPSHEHIANQELSFHTSVIDMDILQQNVILSCRFSACGKNPYTENANTSYYSAVLTFSYVQKLVLPPMRVSKTRFPKKPGGTTSVPQDTSLGQLTIDINVHESGITHHGLPPDQTTEDTHCPVSVTRNGLMWCLLPTNLTSNRCFLSAVGSALVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PVJ0</accession>
    <name>A0A162PVJ0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_67628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292486.1">
        <property type="nucleotide sequence ID" value="XM_018441826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PVJ0"/>
    <dbReference type="GeneID" id="29002732"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_67628"/>
    <dbReference type="InParanoid" id="A0A162PVJ0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="140" mass="16166" checksum="92673D3995470702" modified="2016-07-06" version="1">MDIKKILKPTLGDINTFMPSTLVHSIFNGDCVIWSDESKFMLFDNGGKTRIGKYPKGSYFNSHELSKLDTAIRVERSNILAEIFKTHCMSIPNCIHEMKRVHGGHELLSERRSTKLRRLQWSLDNFKVKAGTKRLEIIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q5U2</accession>
    <name>A0A162Q5U2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_120337</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298406.1">
        <property type="nucleotide sequence ID" value="XM_018428736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q5U2"/>
    <dbReference type="FunCoup" id="A0A162Q5U2">
        <property type="interactions" value="173"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162Q5U2"/>
    <dbReference type="GeneID" id="28989642"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_120337"/>
    <dbReference type="InParanoid" id="A0A162Q5U2"/>
    <dbReference type="OrthoDB" id="1658724at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="126"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD80366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="294" mass="34661" checksum="A43232A86BB824CA" modified="2016-07-06" version="1">MNSTLTDSTPYQLNWLEIQWAQMYEGRNPLVVTGIFAFLLHELVYFGRFIPFLICDFIPYFQRYKLQPKKINSKDDYWKCTKSVLYQHFAFEGPLILLFHPMASLLGIDIDVPFPSWSVIAVQMGIFFFIEDFYHYVVHRIMHWPPLYKKVHKIHHEYSAPFGIAAEYAHPIETSILGLGTIGGPLFYHAVVKYFFSSSPGWNLHLFSMLVWIVLRLVQAIDAHSGYDFPWSLCHWIPFWAGAEHHDYHHQAFVGNYASSFRWWDYIFGTDKKYRAYRKQQAAAKRSLDKKKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TBB9</accession>
    <name>A0A162TBB9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_72360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441008">
        <property type="protein sequence ID" value="OAD65723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283763.1">
        <property type="nucleotide sequence ID" value="XM_018442645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TBB9"/>
    <dbReference type="STRING" id="763407.A0A162TBB9"/>
    <dbReference type="GeneID" id="29003551"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_72360"/>
    <dbReference type="InParanoid" id="A0A162TBB9"/>
    <dbReference type="OrthoDB" id="2213130at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="447" mass="51182" checksum="5039F8187BEBB9DD" modified="2016-07-06" version="1">MSLYFFHLLIFSEYDSTNCENLLKPTVQKNQVTAINETVATWMCRTRVLAMNWRMILLRFHTWYRFHRYVITSDKRLWLSKELKLMKKLLYNQDTNLSKSELIDDDNTSMTLNSDNQESNYYQESVHTPVPVYYGLHSSSLVTTDNVNSINDSASADMAIHNDADPLDLPEHQTSPELPFHVNSSAKWMFKGTNISALFMLFQQSVAAIASSTLLHMETSIHEVLALSHILLLAPQQHSQLMIDTFTEVISDALTKNLVHQSLTLKLNNCDVIYRKVFLIIDSVQMHQLYNDEASVKLLQLCKHVDKHAVCVIRGIAKAIGELPLQAIKNKQSISEYELTTTYFHPILACILSSPKKRVLLLWTNIESDASGDKRPDATLTNLTQLSYEPSLGFGEAKVAQPNTNDNYLCYDFLRLKVFCKEAIGTHHWKACFVFQIHGFTIVFYLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TBG6</accession>
    <name>A0A162TBG6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_153243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441008">
        <property type="protein sequence ID" value="OAD65763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283803.1">
        <property type="nucleotide sequence ID" value="XM_018433097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TBG6"/>
    <dbReference type="GeneID" id="28994003"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153243"/>
    <dbReference type="InParanoid" id="A0A162TBG6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="40166" checksum="13FB26186C44853D" modified="2016-07-06" version="1">MTKRIPTAPRRPNLRMNAVLNSTIAGVVAPIDTPTPEVAVDTAPEVQVAVTPMDHVLTLLAANNVSMQSLQENAKGVTDAITHLKNGLDLSNKTNKFLKNSVLQLMTENAEIKKAMTSQNSVMPSAVPADSSSSMDDDLDLGAKHHPLISQLINSYIKKPNFVSTDLLKVAENNNRSAWSMTGTYGDKYNKTLALALFKYLRPQRCCTNVSKSVIMNIIKNHYQNQVRVFRTSAEKIMVRNKAGRRRNRKKTLLDRRIITYQTYTEAIHEGMNRYDCGNILSIDVMSDGESDGDNKVPAYRPSWRTDELQTFISTIDELTVIHLKKNSESLKKRIPYEKEVSIPKNLAVTLPDWCFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TEE5</accession>
    <name>A0A162TEE5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PHYBLDRAFT_178284</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285982.1">
        <property type="nucleotide sequence ID" value="XM_018437971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TEE5"/>
    <dbReference type="FunCoup" id="A0A162TEE5">
        <property type="interactions" value="525"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TEE5"/>
    <dbReference type="GeneID" id="28998877"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_178284"/>
    <dbReference type="InParanoid" id="A0A162TEE5"/>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000007">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0749">Sporulation</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 19" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="20">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="18">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OAD67942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="150" mass="17161" checksum="6ED413F3CCC4B4AF" modified="2016-07-06" version="1">MSTPSRRRLMRDFKRLQSDAPGGVSGAPCSDNIMQWNAVIFGPSDTPFEDGTFKLELHFEETYPNKPPQVKFISKMFHPNVYANGELCLDILQNRWSPTYDVAAILTSIQSLLHDPNPNSPANAEAANLYRENRKEYVRRVRETVESSWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TFT6</accession>
    <name>A0A162TFT6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_174819</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV441000">
        <property type="protein sequence ID" value="OAD66793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284833.1">
        <property type="nucleotide sequence ID" value="XM_018437349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TFT6"/>
    <dbReference type="STRING" id="763407.A0A162TFT6"/>
    <dbReference type="GeneID" id="28998255"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174819"/>
    <dbReference type="InParanoid" id="A0A162TFT6"/>
    <dbReference type="OrthoDB" id="2966465at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007839809" description="DDE Tnp4 domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="23"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD66793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="211" mass="24126" checksum="FF762CD47F1911B1" modified="2016-07-06" version="1">MNSSLTLTSFLLKTTFPNVVGFVDGTMQKASCPSSYKDQKLVYNSWKHIHCIKYQTIAIPDDITSSLVGSFIESTHDARIFDKSKTLDRLIAHLDHISKDNNVPFEYIVYGDMAYPKSDKVYKSFPLSEANNDIEIEFGKVSQLFKFCKYNYGMKIFANTKPATIYILSTLFKNSHMCINDSAGSKLFKLQPPNIHDYIKGLMYERQPGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TGW3</accession>
    <name>A0A162TGW3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_156390</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286532.1">
        <property type="nucleotide sequence ID" value="XM_018433486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TGW3"/>
    <dbReference type="STRING" id="763407.A0A162TGW3"/>
    <dbReference type="GeneID" id="28994392"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_156390"/>
    <dbReference type="InParanoid" id="A0A162TGW3"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF4">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="9">
        <location>
            <begin position="31"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD68492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="396" mass="44537" checksum="F3BF08D7E5913342" modified="2016-07-06" version="1">MSRWSLWSSRAITHSRRFYSAKAPDIEVDNLVVGGGVIGLAIAEKLTRARSAETTVLVEKNGAIGEETSSRNSEVIHAGLYYPIDSLKTRLCIQGNRMLYDIAARKSIPHKRIGKWIVAQTPEQHEYLTKMHQKANSLGVETHFLDKQQANKLEPEIQCHSVLVSPSTGIVDSHALMEYLAETAQQQGGDLALSTRVRKIETSEGQYRVTITSPLENEPDTVVLAKRVFNSAGLHADKISNMLMPDRYKLYYAKGHYFSYNAPNNIQHLIYPCPEKNLAGLGTHLTLDMAGQIKFGPDVEYVDRLEYNVPDNQDKIKSFGDAIHRYWPPLDPQKLQPSYAGIRPKLARPGESFRDFEIREERDSGYANFYTLIGIESPGLTCCLAIADHVHELIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TIH8</accession>
    <name>A0A162TIH8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_118276</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285463.1">
        <property type="nucleotide sequence ID" value="XM_018428625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TIH8"/>
    <dbReference type="STRING" id="763407.A0A162TIH8"/>
    <dbReference type="GeneID" id="28989531"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_118276"/>
    <dbReference type="InParanoid" id="A0A162TIH8"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14081">
        <property type="entry name" value="STKc_BRSK1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="14"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD67423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="327" mass="36519" checksum="640D19033B4DE5CB" modified="2016-07-06" version="1">MSPGNRRRKDIGDYWLGKTLGRGSSGRVKIGIHKITGEKVAVKIIAKSHLASNVSVEKAVKREIAVMKLINHPNIMSLIDVIDLSDSPNLYLILEYVQGGELFEYLVSQGRLQESEARKYFQQIIFGLDYCHRHLICHRDLKPENLLLDKEKSIKIADFGMASLQPAGSLLETSCGSPHYASPEIVNGIPYDGSASDIWSCGIILYALLSGHLPFDDDNIRQLLNKVKVGKYKMPEHFSDDAKDLIQSILVIDPAKRLTMKQVQDHPWFTVDPPENPSTLPDPPTAEEIGRPVSDASEIDDRILATLKDLWTDLTAENVIEALLNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TL40</accession>
    <name>A0A162TL40_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_172072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287472.1">
        <property type="nucleotide sequence ID" value="XM_018436729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TL40"/>
    <dbReference type="STRING" id="763407.A0A162TL40"/>
    <dbReference type="GeneID" id="28997635"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172072"/>
    <dbReference type="InParanoid" id="A0A162TL40"/>
    <dbReference type="OrthoDB" id="3263820at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="720" mass="82925" checksum="8C5612B84C2FBECF" modified="2016-07-06" version="1">MAPIRKPTVRKECRCSICKSKTLGFDCVSVKTFKRHQEKDNHDITHVQTPHEDTCDTISSAVSEPVNQEEDGFEFEQEDVEMNSELINLNDTNDILDIRTRNQPFSETDCVFGPEDNVQYTSDTYEEEYEDESDVEMDNDEDSSLESILELNLIHRFIVISVALFVSLYVVDEGAVILIAIINKILQFLFDPFRLPVSVAGLKRLAGFEALTSGVKKYVACSKCHAIYDNEAAPLCCTSPNFVAHGVRWSELHRLQYFDIVRCTIIDPMHNLFLGTAKRMLERWVADGLIDDKKLVAMQKAVEKVVLPPDYTSLGTKIAKGFPYMKADEWKSWCLVYSPVVLRDVLPLPEFKNWIEFVNACRYFTKPSVSEEDIEKGHKCLEEFCKGCETLYDLDLLSPNMHLHLHLRQTMIDFGPVYGYWLFSFERYNSVLKNIKTNRRNGFESTFMRQFIEESWKGDFVRRLLKPMHALACFEIFDKFTTNNNNTNTNTNTNTNTNTYLSHSFSISEYLEASQNLSMIIRGNEPLPPSALPLKTRPLSFMSKHEYDCLVGYYQAAYKNPQISGCKDVIDDSPFVNDWIEMVKSVDLLGQSYKGCIGTNGRGSYIQAYFTERTGSEHAYVGEIQYLFVHNFRPTVSSLTYRNPHSSQHVFAFVKWFKSTSDKTRELEGVELLQNEFYKQDFQSILPVHRILLTVAIVDYKTTKNVNKKLAIPLPKKIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TLD0</accession>
    <name>A0A162TLD0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7719 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_101906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286063.1">
        <property type="nucleotide sequence ID" value="XM_018427650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TLD0"/>
    <dbReference type="STRING" id="763407.A0A162TLD0"/>
    <dbReference type="GeneID" id="28988556"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_101906"/>
    <dbReference type="InParanoid" id="A0A162TLD0"/>
    <dbReference type="OrthoDB" id="5597489at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056136">
        <property type="entry name" value="DUF7719"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846:SF1">
        <property type="entry name" value="DEACETYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846">
        <property type="entry name" value="YALI0B21296P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24841">
        <property type="entry name" value="DUF7719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7719" evidence="2">
        <location>
            <begin position="97"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD68023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="159" mass="18113" checksum="0F1CE8F8DD676C7E" modified="2016-07-06" version="1" fragment="single">EAEKMRLFESTGLLQKVKQREAELAKQHTTSTEYLWQAIFMSIPFAFLLGTFDITVKVQFSEPWTYSGLLIKSLKSIPALIPFIYLTNRYKSSNITQTIMATSSVVVGSFLLYTMHHSPSLGQMMRAPGLATIWVYFVVQLNLLPAVISLLISATYWYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TM07</accession>
    <name>A0A162TM07_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_172229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287632.1">
        <property type="nucleotide sequence ID" value="XM_018436759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TM07"/>
    <dbReference type="GeneID" id="28997665"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172229"/>
    <dbReference type="InParanoid" id="A0A162TM07"/>
    <dbReference type="OrthoDB" id="2255243at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="197" mass="21873" checksum="C7E97B5862064725" modified="2016-07-06" version="1">MTYDSPNDPDRRYQARPYVQDYQDTMPVLEDGLILMDWTGSQPTQDMVYPPISVIPNTFHSFVQPAQTIHPQPAATPSSSFVQQPAVASVPVPVPVPASVPEPVLDTSKPSHPEWGVLKDQEFHPLTLKHQRDLENLYQTGASIIDFHFWQANLGGYCMANMVQKTVVSPDGCCALVRRVVEGAPHPGRKNKKRGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TPP3</accession>
    <name>A0A162TPP3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_71521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288122.1">
        <property type="nucleotide sequence ID" value="XM_018442490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TPP3"/>
    <dbReference type="STRING" id="763407.A0A162TPP3"/>
    <dbReference type="GeneID" id="29003396"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71521"/>
    <dbReference type="InParanoid" id="A0A162TPP3"/>
    <dbReference type="OrthoDB" id="2439011at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="434" mass="49173" checksum="7D8DA71A45507552" modified="2016-07-06" version="1">MSNNEVECSCSVCSPNGRYSVMVSFQTCHRHFADDVQRNFQRQSSIDMVNDNDNDMEIDVKTNISEDLKSVYNLPGSNDEDLSNSYEFNNKCENIKEQLFSHEMPADLTHSFIASFAAYFISKYIINSGSAIFIKFTNEVLAHFGQSFCLPLSLKRLNSLTGLSTLTADIHRFVPCDKCHKIFSESASKSSPQCCDFRKLSGNTCGNNLFLEAPNSLDRSRKVYMYNSITTALSIFFLRPGFERSINLWRFQQEEKYKKQNIVLVGLMPGPSKAKTHQINHYLCPLVAELNQLYSGVAIPTNECSSGTLVRAAILLVACDIPAARKTCGFISHASTNACHVCNCQYSCCSDGKGMDHSGFKFSDWIFNTDEKNKINAERWRQAGSNVKRARLEKENDVCWSELHRLQYFNAVECIIIDLMHNLFLGMAKRMMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TT69</accession>
    <name>A0A162TT69_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_170868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288822.1">
        <property type="nucleotide sequence ID" value="XM_018436439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TT69"/>
    <dbReference type="GeneID" id="28997345"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170868"/>
    <dbReference type="InParanoid" id="A0A162TT69"/>
    <dbReference type="OrthoDB" id="2255243at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="225" mass="24652" checksum="9925F77D6413D184" modified="2016-07-06" version="1">MPSIAPPARRNASRAPSTLLDNDMSIAWSSSPSGPPINYGHAPSSPLPQHQQLHHHHHHHHQQQQQQHHQHHQQQSLGNGVDTESMPLPAMARSSASSASSSTTTIITTSTTSTSTSTSTSTSTNSTTAGPSTQTPAKPYHPEWGVMKDQDFHPLTHKHQRDLETLYQSGAPIADFFFWQANLGGYCMANMLQNIVVWPEGVYALERRIVEGAPHPGRKKKKSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TUV8</accession>
    <name>A0A162TUV8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_178020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD70013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288053.1">
        <property type="nucleotide sequence ID" value="XM_018437942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TUV8"/>
    <dbReference type="FunCoup" id="A0A162TUV8">
        <property type="interactions" value="434"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TUV8"/>
    <dbReference type="GeneID" id="28998848"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_178020"/>
    <dbReference type="InParanoid" id="A0A162TUV8"/>
    <dbReference type="OrthoDB" id="270930at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="11"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="147"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD70013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="395" mass="44256" checksum="BBF052A21287C8F0" modified="2016-07-06" version="1">MAKDGSLFVRFRQFDAYAKTLDDFRVKTLTGASVTVISAIIIIFLVLSELIAYRTPTWVPELIVDKGRKEKMTINFNITFPKMPCHMLSLDIMDDSGEHITGYSHDVYKVRLDLMGVQIKSEKEQKLGDNTKAAEKALLAPDSCGSCYGAVSSREDKCCNTCEDVREAYVNMGWGLGDTDKIEQCLREGWRERIETQSNEGCNVHGHLSVNKVRGNFHIAPGQAFQQSSMHVHDLNNFIAGAPDGHSFDLSHNIHRLKFGPDTNDENEAIMAITNSLAGTNKVTDKTRVVYQYFLKIVSTELRPLSGNPIYTNQYAYTQNERVLQEGNNGLPGVFFNMDISPMMIIYRETRPSFTSFITGVFAIVGGIFTVAGLLDRVMYRAERTIKKMDSGKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TZT5</accession>
    <name>A0A162TZT5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidate cytidylyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_134774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289213.1">
        <property type="nucleotide sequence ID" value="XM_018429671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TZT5"/>
    <dbReference type="FunCoup" id="A0A162TZT5">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TZT5"/>
    <dbReference type="GeneID" id="28990577"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_134774"/>
    <dbReference type="InParanoid" id="A0A162TZT5"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037997">
        <property type="entry name" value="Dgk1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303:SF1">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="26529" checksum="7E825D873987B593" modified="2016-07-06" version="1">MSKKYSIKRKATKTPLEACFPEIQPAGSWEIPRKIFHYSIGFCVYYLYNSGYDTTDIYPSLTAGFAVVVTAEVLRFSFDWFNRIYCKLLGPLMRKTEVSTRLNGVVYYLAGCVIVLWAFPKDIASLSIIYLSWTDPTASICGRLWGNKTPRYGNKSLAGTLGAVVTGSLVTYGFFGPFGLAGGSPSFDNRLSSIGLPLLSVYGGLVAGLSEGIGGVLGVDDNLTIPVLSGIFLWVPLVGLGLGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TZX5</accession>
    <name>A0A162TZX5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="7">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_31745</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="7">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="7"/>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289243.1">
        <property type="nucleotide sequence ID" value="XM_018439980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TZX5"/>
    <dbReference type="FunCoup" id="A0A162TZX5">
        <property type="interactions" value="239"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TZX5"/>
    <dbReference type="GeneID" id="29000886"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_31745"/>
    <dbReference type="InParanoid" id="A0A162TZX5"/>
    <dbReference type="OrthoDB" id="2015551at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000001">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6 7" id="KW-0186">Copper</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="8">
        <location>
            <begin position="14"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD71203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="153" mass="15900" checksum="3EC08472D996AFEC" modified="2016-07-06" version="1">MVKAVAVIRGDSPVKGTVTFTQESENGPTTVEASVSGLTEGKHGFHVHEFGDNTNGCTSAGAHFNPYGKTHGAPEDEERHVGDLGNIHAGKDGLATFKITDKHIKLIGPHSIIGRTIVVHAAEDDLGKGGHELSKATGNAGDRWACGVIGVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U678</accession>
    <name>A0A162U678_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_168921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290693.1">
        <property type="nucleotide sequence ID" value="XM_018435971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U678"/>
    <dbReference type="GeneID" id="28996877"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168921"/>
    <dbReference type="InParanoid" id="A0A162U678"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD72653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="253" mass="28852" checksum="FA4D7693F70EB56C" modified="2016-07-06" version="1">MLTIKNPQTNNNQTTFEGVVSESVSAFSSLGTSGGTYRRDEQCVESREAQSGQNIGNNDSKGNPQTGADMYYITGKIVLHVINNTFDALINKKDVILSWGNLTSFQKNYLVHKVEKKALEKNISLNRFKNSWAVRHMLSQKWRTVINDARKKRKAFHFLKDFFLYNIWLLECIYCLTSVGVTTMISTLGLPTKLASYCSDTVYLEVYRPEVPACLKPSNFFHIGEWKKKLVKVIQGLGLKSWRHLNGPINYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U685</accession>
    <name>A0A162U685_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_145231</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OST4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291802.1">
        <property type="nucleotide sequence ID" value="XM_018431392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U685"/>
    <dbReference type="GeneID" id="28992298"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145231"/>
    <dbReference type="InParanoid" id="A0A162U685"/>
    <dbReference type="OrthoDB" id="2124077at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018943">
        <property type="entry name" value="Oligosaccaryltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051307">
        <property type="entry name" value="OST4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036330">
        <property type="entry name" value="Ost4p_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48164">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48164:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10215">
        <property type="entry name" value="Ost4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103464">
        <property type="entry name" value="Oligosaccharyltransferase subunit ost4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD73762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="115" mass="12787" checksum="FFB6B774CAB890DC" modified="2016-07-06" version="1">MTGCAYDSVGYPSRLQKMESKKKHKKETVGKPIHPHPSTLTTTLTGKPQINNYSFSQGTIKCRQLGAMLGLTGPIPDYKMITDNQLAFIANSLGVMTMLLIVVYHYVSINDVKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U9B7</accession>
    <name>A0A162U9B7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_67548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292572.1">
        <property type="nucleotide sequence ID" value="XM_018441813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U9B7"/>
    <dbReference type="GeneID" id="29002719"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_67548"/>
    <dbReference type="InParanoid" id="A0A162U9B7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="146" mass="16926" checksum="99365A534A4A2B82" modified="2016-07-06" version="1">MPQIPHLIYQTKSKSLQKYRHTAFIRKHALTSSIIKQDKKMYCCNIISVYILESVSTAQSICSIMKQYRAWLERQCVPDVLGLANLKSLFRKFGRQSVRSSQVWFGLVWSGHVRSGQVRYVLNTVKTTSTVKARYSDIRYSDSDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UC37</accession>
    <name>A0A162UC37_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_38715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SGT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD74003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292043.1">
        <property type="nucleotide sequence ID" value="XM_018440111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UC37"/>
    <dbReference type="FunCoup" id="A0A162UC37">
        <property type="interactions" value="609"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UC37"/>
    <dbReference type="GeneID" id="29001017"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_38715"/>
    <dbReference type="InParanoid" id="A0A162UC37"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000012">
        <property type="entry name" value="SGT1 homolog, MIS12 kinetochore complex assembly cochaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044563">
        <property type="entry name" value="Sgt1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45862">
        <property type="entry name" value="PROTEIN SGT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05002">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="4"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="4">
        <location>
            <begin position="177"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="3">
        <location>
            <begin position="278"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD74003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="40292" checksum="8891567478577073" modified="2016-07-06" version="1">MSSGPEFYSKASEAFFDDDYEEAIDLFSKAISLEPTNAEYLLKRGVTYQKTKEFEKALADAKQALSVVQDTKGSNNLLAKAHLQNGIALHQLGHYTEAQKHFETSKELNPNERTLVTWLKKNSDKVPAVITPPAAPPVATATPPTAAAPAPASKLTAANLPEPIAGATVPVPVTPQAVRVRHEWFQSDKFVTVEVFIKNIKAGTVNLEFHDNSISLTIRLPSGSDYNLELDPLAHEIDPSQSSYKILSTKLEIKLKKSLEGIMWGTLEGEDPNTSAMAVASQPTKKGKDWGKLAKEIEKEQEKPEGEKALNAMFQQIYSNADDDTKRAMMKSFVESNGTCLSTNWSEVGAKAVETKPPEGMIAKKYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UFJ9</accession>
    <name>A0A162UFJ9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_142830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293882.1">
        <property type="nucleotide sequence ID" value="XM_018430880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UFJ9"/>
    <dbReference type="GeneID" id="28991786"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_142830"/>
    <dbReference type="InParanoid" id="A0A162UFJ9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="200" mass="22214" checksum="DBD47D214FE60BB9" modified="2016-07-06" version="1">MENLLLRKAAINHCLGCRPVICATNDKRTSNFEVASNDVAGPQLWSRPTRSSLVELAAAIGIECQDLVRSLVPFWAREGIVSFEENDEVVCANKIVRSSVDSRHGRASNLAVLDDAREYGFILKFFSQTVNRVTRLFAAIDCLSDVQRVNQDLFPVWDSLAPGVVKVVDVKSIKGIAGLVHDPNDEAIRHIIWPSPKYNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UHI0</accession>
    <name>A0A162UHI0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_95289</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294322.1">
        <property type="nucleotide sequence ID" value="XM_018443892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UHI0"/>
    <dbReference type="STRING" id="763407.A0A162UHI0"/>
    <dbReference type="GeneID" id="29004797"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_95289"/>
    <dbReference type="InParanoid" id="A0A162UHI0"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000045">
        <property type="entry name" value="ZFP69 zinc finger protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000710">
        <property type="entry name" value="Zinc finger protein 768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD76282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="57" mass="6723" checksum="F26275DF1051B765" modified="2016-07-06" version="1" fragment="single">DNGKYKCSYCAKRFMRPSSLRTHVYSHTGEKPYICTSKGCGRRFSVQSNMRRHLRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UIS0</accession>
    <name>A0A162UIS0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_143796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293583.1">
        <property type="nucleotide sequence ID" value="XM_018431071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UIS0"/>
    <dbReference type="GeneID" id="28991977"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143796"/>
    <dbReference type="InParanoid" id="A0A162UIS0"/>
    <dbReference type="OrthoDB" id="2210827at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="300" mass="33968" checksum="4EA1070267F8A7F5" modified="2016-07-06" version="1">MPSASKKSRLAKSKSRSESGNCFSKNIETSNDDLVDLFEIVVEEDITVDDRELQGITDDVTSAIYSSHFLKWHEGADKSLRDTYQKNSLTTEWRKRKTMKESFDFKGSYLLIVKGFAILSRKESVNEELEPVKVTSRKISANTISLLKLAFNNIKEEIVPFTYISSSSLPVDHYELCKLKSVKSYLRHRLSESKTMEASEKAAMEQQKPESLSTILVKKHIDEVVIPKKLGIPGSVSTSTANQMMGYKTKMASFGENDEVTMPQLSTDKVEHVLITHDESTFYSNDEKEAMWLVEGENPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UKV7</accession>
    <name>A0A162UKV7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_142347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294882.1">
        <property type="nucleotide sequence ID" value="XM_018430786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UKV7"/>
    <dbReference type="STRING" id="763407.A0A162UKV7"/>
    <dbReference type="GeneID" id="28991692"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_142347"/>
    <dbReference type="InParanoid" id="A0A162UKV7"/>
    <dbReference type="OrthoDB" id="2257229at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="294" mass="33110" checksum="94317C91D6EE2E9C" modified="2016-07-06" version="1">MAVADILFLALIDHRPAIMKIYGQRTLSNMCNQVLGELMHANTAKISDSYFIKVTDTINSVDSKAISMRDNKRDLLNLAATMNNTIGNVIKGLANLLMKLPRLSVLNMSKIVEVELQSTYFDMFLPEIFADKDQQVALQWADKSVHQDLTEMRPDAIISTLVQHEFECLFGFSEAKRAIEWHDLPACLAFMINEYSISFFIVSKRHDCLYTMTEIASLDFASSLSNLHTFATCKNLDLLAAVSHCFWSICTHDLPNTATATILQERLDYLVPISNYMSLMAKSSKGTLGQLSQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ULB5</accession>
    <name>A0A162ULB5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_165401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294942.1">
        <property type="nucleotide sequence ID" value="XM_018435229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ULB5"/>
    <dbReference type="GeneID" id="28996135"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165401"/>
    <dbReference type="InParanoid" id="A0A162ULB5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="100" mass="11748" checksum="2B8837C4DF6B31F0" modified="2016-07-06" version="1">MNLVKNIKMNTVDPIFDFPYIIQLEITLHVLSSVYKDNLSLLIYILATVKDIIRNAMDYQYQHLFFARSFPIFTIYFFSVDNYSIQTVSSRPVEAITDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UNE5</accession>
    <name>A0A162UNE5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_185968</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295212.1">
        <property type="nucleotide sequence ID" value="XM_018439175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UNE5"/>
    <dbReference type="STRING" id="763407.A0A162UNE5"/>
    <dbReference type="GeneID" id="29000081"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_185968"/>
    <dbReference type="InParanoid" id="A0A162UNE5"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF5">
        <property type="entry name" value="AMIDOHYDROLASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="3">
        <location>
            <begin position="200"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="569"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD77172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1001" mass="109939" checksum="699FB797FDDE3EDE" modified="2016-07-06" version="1">MESTDPHYDAISVASDGLSPPVPITPPPTFWERVKEFEYARFLKTHLAYVLTCLIGFFLILGFIILPFLPDDGSNKDHYRPLPTFKAPIQPGIPWHVIQAEHLQYCSTLNTSPAQINQNQDQDRNQNGNHGLSGSSKRTTNPRAPKDVRPVLLTNAVVWDGEGNIEEDVDILMVDGIIQEIRKGIVAPNSANIINVQGHVVSPGLVDMHTHLGVMGWPTLVGNLDLNEETNPLTPFVRALDAFDPSDKAIRIVASGGVTTALVMPGSGNIMGGEAYAFKLRPVPTSSNEDMLVQAGQDEASKWRWMKMACGENPRNVYGRQKKMPMTRLGEAFLFRQRIQKAQKLKEQQDDWCYAVSELSQHNTRAKLDSHFPTDLSLESLVALLRGKVLLNIHCYETHDIEAMVRHSLEFNFTISAFHHALEAYRIPEILRRAPNNITVATFADHWGFKKEAFGGIPESPRILHEAGIPVAFKTDHPVINSQHLVFEAAKATHYGLSPQDAFKAITSVPAKSLGLGHRVGSLKVGYDADVVIWNREPLLLGAAPLQVFVDGIALFDEPTINPIKPTEKQQQQQKQQQQQKPFSTSTVSSEYKDIKNLQNFVLTNVGRIFLEEGDNKEEDSFKANSEYQSEQPLQITVRDGKIVCSGISCIDQAATVFQTSDYETIDIQGGYVLPGIIGVGTKIGMVEIPSEGSTGDGVNRSPTRDMSLLPQAVDGIKLQTRHLEEAYKGGVMTIISEPLSNQVLVGVSAAFKTSADSLLSEGALIAPTVALHLQIGNNFKSNFLPTVSSQIAYIRQTFLENKAKPNFVGQAVRGEIPTIVNVHNKDEIASVIRLKQNQFPKLRLAILGGTEAHLVASHLAEAGVSVILRPALCTPSSFDTAHCLTGAPLTDRTAAHVLFSHGVKLGVGVSFDGWTRNLAWDAGWLSVTSPGVKGSPDYISESEAIKMITMNIQEIYGLRDNTLQNRILKDEFVVWSGSPLDLQSRPLFSHANGLSAIDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UUF8</accession>
    <name>A0A162UUF8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_68404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD78092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296132.1">
        <property type="nucleotide sequence ID" value="XM_018441947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UUF8"/>
    <dbReference type="GeneID" id="29002853"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_68404"/>
    <dbReference type="InParanoid" id="A0A162UUF8"/>
    <dbReference type="OrthoDB" id="2447509at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="207" mass="23164" checksum="C3492CDAA8720DD2" modified="2016-07-06" version="1">MSSTQRRCAACHMLGHSRSTHKQCLMNPKNISLHIPQKRTNVDEYPAESSQTAALRIRSEPVQDQNLDIETSTFISVSELTEFPLANETITEVLEAVMEEEIEETSSDEEVTGREEEVEVTSSDEEVTGREEEVEEISTVNRGSILPHCPHCNGTDHRRITSRFCPNNNSSRARGSRNRGRGLNNIARLPAISEPAVDNRGDMDIEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UWX9</accession>
    <name>A0A162UWX9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">4-nitrophenylphosphatase</fullName>
            <shortName evidence="5">PNPPase</shortName>
            <ecNumber evidence="3 5">3.1.3.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_121959</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21664"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57917"/>
            <dbReference type="ChEBI" id="CHEBI:61146"/>
            <dbReference type="EC" id="3.1.3.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Divalent metal ions. Mg(2+) is the most effective.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.41" evidence="3 5"/>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296552.1">
        <property type="nucleotide sequence ID" value="XM_018428839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UWX9"/>
    <dbReference type="FunCoup" id="A0A162UWX9">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UWX9"/>
    <dbReference type="GeneID" id="28989745"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_121959"/>
    <dbReference type="InParanoid" id="A0A162UWX9"/>
    <dbReference type="OrthoDB" id="413953at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000039">
        <property type="entry name" value="Phosphoglycolate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006349">
        <property type="entry name" value="PGP_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01452">
        <property type="entry name" value="PGP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD78512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="294" mass="32776" checksum="2BFD9DE359933976" modified="2016-07-06" version="1">MSLKLESFLERKGFLEKFDNYLFDCDGVLWEGDHVFPGIIEAMQLLRNAGKKVFFVTNNSTKSREAFLQKFKKLGIEANLDEIFSSAVATAAYLKHILQFPADKKVYIIGMSGIQHELEAMDIRCCGGEADNGPFDNEIVKNDPEVGAVVVGLDTQVNYKKYNKAFTYLRNNTGCYFIMTNQDSTFPVHGTLQPGAGSIAAPLITALNRQPDAILGKPAQNMMDTIFAEYKLDRERTCMIGDRLDTDIDFGLKGGVETLCVLTGVTSEEEILSKENNIVPTYYIRGFADFVVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V190</accession>
    <name>A0A162V190_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-loop-helix DNA-binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_162399</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297363.1">
        <property type="nucleotide sequence ID" value="XM_018434610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V190"/>
    <dbReference type="STRING" id="763407.A0A162V190"/>
    <dbReference type="GeneID" id="28995516"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162399"/>
    <dbReference type="InParanoid" id="A0A162V190"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF3">
        <property type="entry name" value="SERINE-RICH PROTEIN TYE7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="236"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="306"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD79323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="947" mass="106300" checksum="A61C9A09EDA94978" modified="2016-07-06" version="1">MTGRFQDINSYQPSERPRPARYTSGMSDFLFSDTSGFDMMGWDMDPHSHPDHHSPHSSPYTTNSDYTALSPVTSISPHFSGVGEMQSLDNLNSCEEATKALAGYQYNTTQNSNTLSSSSSSSNPKGSFSFTSLHALNGNVPGIAIPTTPATTDQAHNQVIHTHPSLSPSASTSSASLSPLMESHSPLTGAFMAMNPWGTDKAPAYTSDEHETRRWRTSKHSDDDHHRTRLEPGQQLKKVAHNAIERRYRNNINDRIRDLKNVVPALYKARIKEKGQDDDDEDDNSETEEIVDGVQVATKLNKATILRKATEYIQFLKHDNDQAERENQILQQIISQMPGGNHVLNRFRTQKSAYEKAEQERLCRERKEQIEHEREERQRLLRERAAQRAALAQLVPKPERRPYRRRKQKALPKKKEEEGTKMFMAMFMALAFFSTSPTTSTTPSTHAAHANARTFSAYTNTTTPTYRTLFGVTSNASDLWFTIRWALLAIGIFYTCVLPLWSHWLRPRRVLRGKKCSGHNHNHNHHHYASDVPQAWHHLFESFANLISLESASNTAQTTIGLIRDLIYITLPSFIQPRAKIGPKQLSRSGAWVRVAETECLGGNSETSYIHMLRSCVGMLANVKPLEISSQSSLYLRPRTIARIYATAAIQLELTLPAVLSEPLANHCWSRVVDAFEQAREVHDTKDSDEHWMTQATGIPEWPVSSNHKEILSMVQARSGLVGRQSAAVCQNIFYSFVLPYLTSPLEWIVYWQHLSSLQDSWIAQLQQNKSTLFKVSQLPPSTTTAVDQMLSWSIHLGLSLQSDELRSSASMVSLSESLKASSSGSQTVSHLLQRHRSMVFYTLQGAKLLERNDTEAALQSFALAQNDSRAGLDCIRHIATSNVEASVLALSTLAVTWHAFKILSRHPELKTTMVSVRDRLTRSLALSSGHLPGTIKRSVQASLLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V343</accession>
    <name>A0A162V343_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_75588</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297672.1">
        <property type="nucleotide sequence ID" value="XM_018443077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V343"/>
    <dbReference type="FunCoup" id="A0A162V343">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162V343"/>
    <dbReference type="GeneID" id="29003983"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_75588"/>
    <dbReference type="InParanoid" id="A0A162V343"/>
    <dbReference type="OrthoDB" id="19679at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019148">
        <property type="entry name" value="Nuclear_protein_DGCR14_ESS-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940">
        <property type="entry name" value="ES-2 PROTEIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940:SF0">
        <property type="entry name" value="SPLICING FACTOR ESS-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09751">
        <property type="entry name" value="Es2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="384"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD79632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="422" mass="46492" checksum="CFBB99ABE63FAF3A" modified="2016-07-06" version="1">MSTNPVVLDEDTYTEAISYIIERDFFPNLAKLKARQNYFQAQESGSLVSLQQAGKALSDLSQTPLQRTAGAPESLPQNFYNQDEPELATRVNLNLSLDQFQTLYTSEDNASFTDLLEKANAKRKDKYKLIFDETANRLLIEGVPNNGASLKRVKADEAPPGTWKYMPRNALMYFADGTGGTLLNEADSRAPPRAIAHGNTQLEIEEEKEKSETSLKPSDIAAQQGKMTPWKEINGLDNSHTPEFRGFSLVDATPSPTPSRMGTPIMTWGSIEGTPVLIKGSETPGPQFSLPKASRREALGMRLSERASRAYRKKTKERANAVRGTPRSGQGYTTKKKGGSWSYVSGCSTFDANTHSIFFGRIRCCTPVILRLAFDRKTRTNSWSAMADRRPGATPTPLFRAGATPGTATFKTPFGDTPVKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V8R9</accession>
    <name>A0A162V8R9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_61887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298872.1">
        <property type="nucleotide sequence ID" value="XM_018440868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V8R9"/>
    <dbReference type="GeneID" id="29001774"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61887"/>
    <dbReference type="InParanoid" id="A0A162V8R9"/>
    <dbReference type="OrthoDB" id="2302687at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="351" mass="40342" checksum="D1716C0D96654BBD" modified="2016-07-06" version="1">MNPTFTNTNSIHQNVLNMVPSQEITVFQEVPQSGRTQTVGRPSAWNDNIIKVLLRLIIDTGFYAKHAILDNSGKTRLWQKLHDDFCNHLDVVRYAASPLNAGFSSKYEAVKYIKDKFQSIKKDFQKITAEIRRTGSGGPPPQERYIHFDDMKEITLSNPGFFLSMLMETGRVVEEVVAEAVISICQDDGVTYKNTQLTTPSFVSEGRSEMSQWSYSTPNPVPSPRQGTEPVSTSGTRRTTPSELQQAFLENSRSQTDIMTSMHDLLSTRYQRLEELYEDTLQQYRLDVIASQEARRLDWESRELIATREYNRQVIADEREEESRRSLLEILSRRKRSRGPSSYLTRINELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WAJ6</accession>
    <name>A0A162WAJ6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_175638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441007">
        <property type="protein sequence ID" value="OAD65895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283935.1">
        <property type="nucleotide sequence ID" value="XM_018437534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WAJ6"/>
    <dbReference type="GeneID" id="28998440"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175638"/>
    <dbReference type="InParanoid" id="A0A162WAJ6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="115" mass="13330" checksum="71EA387EE6FB6BAC" modified="2016-07-06" version="1">MLVLNVYRYHVMGIFLKLILKPSDVVLHDFASNALKSLSKNVEFTKCFFFVIWSCLTYMHMSAIKTVIPFKVTELDVGQNVLATISIHRSLNKDISSERIRRQRFAQKKLHSLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WGX8</accession>
    <name>A0A162WGX8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_151997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD67055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285095.1">
        <property type="nucleotide sequence ID" value="XM_018432804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WGX8"/>
    <dbReference type="GeneID" id="28993710"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151997"/>
    <dbReference type="InParanoid" id="A0A162WGX8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="177" mass="19621" checksum="38A8CB74E22D9E92" modified="2016-07-06" version="1">MNNTNNNDISLLHSIYNEILSLKAGQENFKLEMKTQIKELKLEITTLKNQPETQNTLNQDTSPFLTTILGSNYIHKPAENFCDITLMHIFKMISEDLGIEVTSHVKAILTLTTKLICDDMAAHLLMIALGPNPSWGSIPAAVKKEMYVSHASIMKDSGIDFTGCLGNWASTARVALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XIP9</accession>
    <name>A0A162XIP9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_167464</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293185.1">
        <property type="nucleotide sequence ID" value="XM_018435644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XIP9"/>
    <dbReference type="FunCoup" id="A0A162XIP9">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162XIP9"/>
    <dbReference type="GeneID" id="28996550"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167464"/>
    <dbReference type="InParanoid" id="A0A162XIP9"/>
    <dbReference type="OrthoDB" id="10054429at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF26">
        <property type="entry name" value="OS04G0435100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD75145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="57387" checksum="2E5FC0D94694BD09" modified="2016-07-06" version="1">MGSADEKPDINLEEAPAHVMDADELLLQSLGYKQDLNRSISAFSNFAIAFSCCSVLSGLTPMWGDAMIDAGSLGVIWGWVITGIFTMIVAMSLAEICSAYPTTGGLYFWVSRLSTSEWVPLACWLTGWCNWVGLAFGITSVDLGLAQFIAGVINIWSPETDTSVYMQYGIFVGILICHGIINSIAVNLNGIMNQAAFWLNMLGIIFIVVVGLAITRPLATGDFVFTQFYNGSGFSSNGFAFLLVILQSQYTLSGYDSAAHMSEETKNSQTGSPFGILVAVAANAVSGLVFLIAISFMVTDFMGQIVSDDAIQPQMIQVFYSGVGPAWTMVFLVFVMLSIFFCGSALTLGSSRMVYAFARDGAMPFSKQLHSINPKTKSPVFAVWFNVTVAGIVGLLYIINSTAYEAIVSVNTIGSQMSYLIPILLRITVSRNKFTPGPWNLGRYSVAVGYIAAAWLIFTCCLFICPTEAPVTPDNMNYAIVPFAAIMLFSSGYYFIWGRKWFTGPVRMIDGEAVILEEGDEIPEKSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XWQ6</accession>
    <name>A0A162XWQ6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_62902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294955.1">
        <property type="nucleotide sequence ID" value="XM_018441032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XWQ6"/>
    <dbReference type="GeneID" id="29001938"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_62902"/>
    <dbReference type="InParanoid" id="A0A162XWQ6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="156" mass="17585" checksum="6B78F09B1A55973B" modified="2016-07-06" version="1">MLYSVINIQKKLGVKRNNKVKNTLVLLPSDASPSQCPFGLAKAISPKLLSTIKHGYEHDEPPSHEHIANQELSFHTSVIDMTILASPMYSLGLQINPFASGSILSTMVRIHDVFSFCLCKQHTTGLFSERYCLENTCFIRTLAISNYWRSVWKQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y5Y4</accession>
    <name>A0A162Y5Y4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Galactokinase</fullName>
            <ecNumber evidence="3">2.7.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Galactose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHYBLDRAFT_74616</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>alpha-D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13553"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13554"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.6" evidence="3"/>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296525.1">
        <property type="nucleotide sequence ID" value="XM_018443028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y5Y4"/>
    <dbReference type="FunCoup" id="A0A162Y5Y4">
        <property type="interactions" value="374"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162Y5Y4"/>
    <dbReference type="GeneID" id="29003934"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_74616"/>
    <dbReference type="InParanoid" id="A0A162Y5Y4"/>
    <dbReference type="OrthoDB" id="187738at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000411">
        <property type="term" value="P:positive regulation of transcription by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.340:FF:000003">
        <property type="entry name" value="GAL1p Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000056">
        <property type="entry name" value="GAL1p Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="15">
        <location>
            <begin position="33"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="13">
        <location>
            <begin position="122"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="14">
        <location>
            <begin position="391"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAD78485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="495" mass="54784" checksum="547735E8136ACFD8" modified="2016-07-06" version="1" fragment="single">MSVTVPVYDTLESIYDISSVAKQGVRYNRLIDQFTETYGRKPEFIVRSPGRVNLIGEHIDYCGFGVLPMAIERDVVIVGATTDADSKTRLTNADPKYPPREFDYEGKEKVVTIDASELEWSNYFKCGYKGMLERANLDKPKGLSLLVDGNVPAGGGLSSSAAFVCASALAVIVANKLPSTKQELTEIAIVAERNVGVNSGGMDQSASVFSEKDYALRVEFVPRLSAQRVKLPQTKPALAFVIANTLVKADKFVTAPRHYNLRVVETKMAGLFLSKALGLPKTVDTLKEVLDLYFASSSLTEEQKLTQLLERAEELFPEEVASGGNGYTLDEVSAMVGWSKDELHEKYMSRFPVQTDFFRVRQRTHHVLTEARRVYQFSDACEDQSSDNTVKVLGELMNESQDSCKNMFDCSCPEIEQICEIARRHGAYGARLTGAGWGGSTVMLTDVTNVDKLINAIKDEYYRPTFPTMSEEELDDAILSTKPCSGSAVFDGFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YH49</accession>
    <name>A0A162YH49_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_61687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298675.1">
        <property type="nucleotide sequence ID" value="XM_018440842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YH49"/>
    <dbReference type="GeneID" id="29001748"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61687"/>
    <dbReference type="InParanoid" id="A0A162YH49"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="139" mass="15430" checksum="8B5848A96C7CB63D" modified="2016-07-06" version="1">MAKEGGKAIAGMPYVMMGYWTDCTSGVDHESLVDLNACEIPAKLFVGFQGRRFSKHPCVVADKENPAQDYQNQGKATLVLIEQKFGVCFSCYINTSQHLACDQDSWVELRSNIIQPSVSTITKVDRSLQNQPICLLLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZSW4</accession>
    <name>A0A162ZSW4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_159954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286861.1">
        <property type="nucleotide sequence ID" value="XM_018434088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZSW4"/>
    <dbReference type="STRING" id="763407.A0A162ZSW4"/>
    <dbReference type="GeneID" id="28994994"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159954"/>
    <dbReference type="InParanoid" id="A0A162ZSW4"/>
    <dbReference type="OrthoDB" id="6127170at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="196" mass="22900" checksum="B234453B31647DBD" modified="2016-07-06" version="1" fragment="single">MISETTQIDFSGFEYSTWTKRTKARNLGYANKWKEAKNAAEYTQLERRNGTQWSQLHLLTYFDPVWCTIIDPMHNLFLGTAKCMVQIWKELEYFDNQALLAMQDLANGVVVSPDYAYINKKIADRFSSIKADKWKLWCLIYSPFVLKHILLVKHLSNWMFFVNACHLPTKPSVTSDKISSAHAHLQLFCKGFEKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AG23</accession>
    <name>A0A163AG23_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_133744</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291291.1">
        <property type="nucleotide sequence ID" value="XM_018429590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AG23"/>
    <dbReference type="FunCoup" id="A0A163AG23">
        <property type="interactions" value="442"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163AG23"/>
    <dbReference type="GeneID" id="28990496"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_133744"/>
    <dbReference type="InParanoid" id="A0A163AG23"/>
    <dbReference type="OrthoDB" id="10248551at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000002">
        <property type="entry name" value="40S ribosomal protein S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="4">
        <location>
            <begin position="26"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD73251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="122" mass="13772" checksum="43DDA6B32FE94722" modified="2016-07-06" version="1">MSYVAKNSTEKAGLEEQAQPKIHRIRITLTSRNVKNLEKVSADLIQRAKDKQLKVKGPVRLPTKVLRITTRKSPCGNGSETFDRFEMRIHKRLIDLHSPSEIVKQITSISIEPGVEVEVTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ANP9</accession>
    <name>A0A163ANP9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_167080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292771.1">
        <property type="nucleotide sequence ID" value="XM_018435561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ANP9"/>
    <dbReference type="FunCoup" id="A0A163ANP9">
        <property type="interactions" value="176"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163ANP9"/>
    <dbReference type="GeneID" id="28996467"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167080"/>
    <dbReference type="InParanoid" id="A0A163ANP9"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="327" mass="36066" checksum="5DE4E9E8291A96A5" modified="2016-07-06" version="1">MDKTIIPIAYSADQTYTGAGEPPFYQPLLRLFNKEWNYSKTNLIGKVAIVTGANDGIGKESAIDLAKRNATVIIACRDSEKSRQALEDIRLASGSDKVTLEYVDFASLQSVKDFYTAFIATHKNLHLLINNAGVFNTTRKETVDGFEGTFGVNHVGPFLLTELLLPTLIASKPSRIINVGSAGMRWATINFDDIQLEKNFSGFGSYGQSKLANALYAYHLSRRLSGKGVTANVLHPGAVRTSIAARDKKLLNTITTTIFGLFALYTKSPIQGAQTILYLATAPEVEEKSGLYWENCAVHSPINKLENDEDTQNRLYEISNLLVKKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AQV4</accession>
    <name>A0A163AQV4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_67913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293191.1">
        <property type="nucleotide sequence ID" value="XM_018441864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AQV4"/>
    <dbReference type="GeneID" id="29002770"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_67913"/>
    <dbReference type="InParanoid" id="A0A163AQV4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="102" mass="12345" checksum="87A3B7300DCE33CC" modified="2016-07-06" version="1">MQEVKVKLKLKLKTVFCKERPYSARRVPANLFILQKRNFDSTSLKVLRGSLRAPWKHQKKYIYMYSAQSKRTKIPWSNLQTYNRIFAESNLVNQQSRYQRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B125</accession>
    <name>A0A163B125_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_76469</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295711.1">
        <property type="nucleotide sequence ID" value="XM_018443156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B125"/>
    <dbReference type="STRING" id="763407.A0A163B125"/>
    <dbReference type="GeneID" id="29004062"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_76469"/>
    <dbReference type="InParanoid" id="A0A163B125"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000067">
        <property type="entry name" value="ras-related protein RABA1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="177"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD77671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="235" mass="25527" checksum="F6123A47571547AD" modified="2016-07-06" version="1">MLTDDEYDYLFKLVLIGDSGVGKSNLLSRFTTNEFNLESKSTIGVEFATKNIKHENHVIKAQIWDTSGQERYRAITGAYYRGAVGALLVYDITRQSSFQNATHWLKELRDHADANIVIMFVGNKLDLSDTSRAVSSEEGGALAEQEGFLFMETSALDATNVEKAFATVFSTIYAKQPKSGETQPGQAGGPTPTAGERVQLRPPSVRGQPRGSMDESKEGRKRSAEGSNGSGGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BA08</accession>
    <name>A0A163BA08_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_162221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297181.1">
        <property type="nucleotide sequence ID" value="XM_018434588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BA08"/>
    <dbReference type="GeneID" id="28995494"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162221"/>
    <dbReference type="InParanoid" id="A0A163BA08"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD79141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="153" mass="17896" checksum="D0CA03DE47D475D0" modified="2016-07-06" version="1">MRRYEWKATGLILSNGTTSYIRHFLEPTTTTTNDKNAMVLQRLVISIELNWFKGKKKKYGLRRLGLILMSLSDTGGSIRNDTIVSYLVRAIRLTFLEFAVKWDFDIYPVDYSNALTVKYQIWGSFAYCFPIYEELENSADRNCTNQSMEYLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BAN0</accession>
    <name>A0A163BAN0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted coth spore-coat protein domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_58320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297311.1">
        <property type="nucleotide sequence ID" value="XM_018440296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BAN0"/>
    <dbReference type="STRING" id="763407.A0A163BAN0"/>
    <dbReference type="GeneID" id="29001202"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_58320"/>
    <dbReference type="InParanoid" id="A0A163BAN0"/>
    <dbReference type="OrthoDB" id="2387105at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050">
        <property type="entry name" value="INNER SPORE COAT PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050:SF1">
        <property type="entry name" value="INNER SPORE COAT PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0946">Virion</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007841874" evidence="2">
        <location>
            <begin position="21"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="563"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD79271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="637" mass="69269" checksum="DDD98464E0A282DA" modified="2016-07-06" version="1">MKFTSLSFIAFAFLVACTEASPVTFRVIAPGATGNAQVSIDGKVTDLTASDADVPYFTGSVEAGTSGKYKYVVNGQAESFDRTLETGRNATRNDFFSRPVTYANIPKLPWPITENPQWTRGGSNQEMWDDNYIPSIFMTGDAAELSDLVANVPATMSTVKFTFIGPETVRVYNGCSFGIHGAGKKKNNAKQSWKWSLPAGQTIDNRNYIKIRHMEEDPTQLREKLYADILRAMGTYANQANMVRLFINGEGYGTFNMLDDVADYSYIDAMFYNGNPPATKGPLFDGASGASFAYSAEDDFYSAFKPNVDSPQDYTAIKPLALEFSQTDVTSDAAIEAFSKKFDVDQFLRFMVMEYLTGHWDGYWQEQTNDGAYQDPTDSKWYYLGQDYDATFGVNLGAAEGKEFTKVSYTTYPTRYPGAVMINRLLENPSIKTKFETYIKNTVSVLFNNVTLTNRVLAYHEFVLPDLLWDRSIVQKSPGINFGWTADQVSQNLYEAVSGSGGEGGGAAWGLIEWIVSMSQAVATEFKVDITTVPVGPPGGSAATTPSTSASVAASVSKSASPVSATGATKSTGSSSSSKDTDGDISAASKDGSGAFQITPKTAFSAIMIGSTALLSALCKLIKRLPFVLISNNHRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163D4H0</accession>
    <name>A0A163D4H0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_117097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286700.1">
        <property type="nucleotide sequence ID" value="XM_018428562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163D4H0"/>
    <dbReference type="FunCoup" id="A0A163D4H0">
        <property type="interactions" value="170"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163D4H0"/>
    <dbReference type="GeneID" id="28989468"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_117097"/>
    <dbReference type="InParanoid" id="A0A163D4H0"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="33892" checksum="8717281E3E9EE73E" modified="2016-07-06" version="1">MSSSPITQVPDHPSHQDSNSLQKGNAIPTHLKLLLRGVPMYVKRDSLVSLPESLLVAIFPNGFVLTADKNPAPTDTSGLVGESDFDPKCFSYILEFFSEAAETFAKENQDHSWEAFSAGLVGAYSRQFDSARYSLLTKQAIVVLREELEYFILPQDKSNPLTSTADIITLKQLKQTAGQLLKADDLVFHSMLQNVKRGNNIVERELVDMLCDCGFTRLDRWFYRELESKKTFITSVSLVKLKVEDKDNIMESAKKLMVFWKKPARKCWWDYTLTKLDNIQVRLWVRRTWILELSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163D819</accession>
    <name>A0A163D819_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_66339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287480.1">
        <property type="nucleotide sequence ID" value="XM_018441628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163D819"/>
    <dbReference type="GeneID" id="29002534"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_66339"/>
    <dbReference type="InParanoid" id="A0A163D819"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="172" mass="19320" checksum="7C7920AA04011EEB" modified="2016-07-06" version="1">MTCKKKFCLLLKDLPNKAIDSRGYKKAIVTPKKSLVVYNVTEKLALHIANKIIAFFLLQHQRIIFLTFNMSNINNINNANKIVIVSKLSKKYDTALTEFNSIFLVRREFSSVVAVREAARAYGAKHNIALTTAYSSSSRIKLICKHSGEYRDIRKAEKAAQVLVNGESPLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163D9R4</accession>
    <name>A0A163D9R4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_70551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287840.1">
        <property type="nucleotide sequence ID" value="XM_018442296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163D9R4"/>
    <dbReference type="GeneID" id="29003202"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70551"/>
    <dbReference type="InParanoid" id="A0A163D9R4"/>
    <dbReference type="OrthoDB" id="2206081at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD69800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="353" mass="40354" checksum="1B575FE107C37D5A" modified="2016-07-06" version="1">MIELSPFAERIVDRMNMIGMWLAVVICARNFHISLKQYRRTRVMFMRLVIIETERHSKWIKCVGVFFIALRFADWPYELSYLNVQHKNMTQEVPTGVTCLTEWVTGVLILNFVSDSLANLFLSGMFVRRLYKHIRRSRTVMSQQNSLIEYIARKSLVCLILAFVANFAMNLLKVTEFLGDRTDSFTVYFEIVESTLLVEALRADSVSPANTSMCNNCGMALHISHNSNSINVGRSDKPEPDCGSQPSQHDNTCQRAENSVSISTDPYLPELDKVHQDSLQYNPFVYPKDNTVNSTVSAPTFALTSRPKQVSSRSPFKSSNVKASVEITSFSSIDGHRRLADNREWNNNDYRMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DR79</accession>
    <name>A0A163DR79_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_113126</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290990.1">
        <property type="nucleotide sequence ID" value="XM_018428329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DR79"/>
    <dbReference type="STRING" id="763407.A0A163DR79"/>
    <dbReference type="GeneID" id="28989235"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_113126"/>
    <dbReference type="InParanoid" id="A0A163DR79"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD72950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="83" mass="9411" checksum="8158155829D70370" modified="2016-07-06" version="1">MVNIYTLKDVSKHNTKEDMWVVLHNKVYNVTAFVPAHPGSEDILITRAAGKDATEAFEDINHSELARETLEQFMIGQLHEDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DS22</accession>
    <name>A0A163DS22_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_169336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD73080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291120.1">
        <property type="nucleotide sequence ID" value="XM_018436052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DS22"/>
    <dbReference type="STRING" id="763407.A0A163DS22"/>
    <dbReference type="GeneID" id="28996958"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169336"/>
    <dbReference type="InParanoid" id="A0A163DS22"/>
    <dbReference type="OrthoDB" id="3261594at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="411" mass="46849" checksum="45087C68D98D2602" modified="2016-07-06" version="1">MNIKDLLNNASETRTSGYMLDDSFFVKCSNRIEDCIIAQACEKSNNRNKVATTAPMDFDKFLAAGNSNHNEAESMDTNDVQVKSVKEINENIDYISDNDYGYLRVRNPYRVYNAPVDHVTDYEHFVPTHVSNSRAQAVSLELFSMFFENNISHEDYDKCIKIVNKYMAELRFTKVDSLLSYYRVNTLLKEKYPVKSIAYDMCINGCCWFSTVEEGDFIDKDETCPHCGEDRYKVERVSVKPAQTFQIVPLLEQLWFKLAHPEEWAKMTYGTRCLAGRCEDICEDIFDGDVVGRLLDCGVVSMFVDQFNPFKNAKMSSSVIYVINLNIYPKERYKTGNMMQLAIIPGPNHPKDIASFLELVLDDLRNLGANDLQFQTDSGLVIAKVHLVMATENTSAVSDLMNLAHHNAHHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DVE6</accession>
    <name>A0A163DVE6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_145134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291700.1">
        <property type="nucleotide sequence ID" value="XM_018431375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DVE6"/>
    <dbReference type="GeneID" id="28992281"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145134"/>
    <dbReference type="InParanoid" id="A0A163DVE6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="457" mass="51767" checksum="66D0B0C6044FFA7E" modified="2016-07-06" version="1">MIATSPCVRTQTMRTHACPDIRSYFEMAKPKFICTKGYASMTDQLDSVEFADDFKHHAKPVTKQGELEIVTKKQVTVSNWKCVYSRKQDPSRRAFTQTFSCEGEARLLSMNLSKPSRDNCIQAIVSPSRWVGQKAHEESRLGYGYNKNKFLIIIRDYWLRTAKKVFEMTGFILWAENTSKEQVEAASRLLLSLDFFVRDNINHWSVHPEDKYYLYTTCLEDTRESLGALDFTKRQSCSGSWRGKPRSGSSSAIWWPNPFVVDPIAASWHIVSAGSLVVYCWWSCIPPAGGQGPFRPVIEEHFAVPGPSLQMMLPIPSQVPFLTKQILSIKPYSALSAPIMRQIQKPESCARMTAARTKIPEMVKPRFAFMSKSNSESCPSQSPNVQNYPSVVWVVPPSLKTKSISKKGSNAKFQKQVPKEKSKTKTEAYTKSCKKKQAYTKSSSPKGSKEIRTRGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DWV7</accession>
    <name>A0A163DWV7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CCHC-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_158827</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291930.1">
        <property type="nucleotide sequence ID" value="XM_018433864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DWV7"/>
    <dbReference type="STRING" id="763407.A0A163DWV7"/>
    <dbReference type="GeneID" id="28994770"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_158827"/>
    <dbReference type="InParanoid" id="A0A163DWV7"/>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038:SF1">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="5">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="87"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD73890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="202" mass="23580" checksum="41410C210A6D415F" modified="2016-07-06" version="1" fragment="single">MALFIGRLPFDVSNRELEDLFSKYGKITRLDIKRGFGFLEFEDKRDAEDAMKGVHGKELGREPLIVEWAKSDGVRRMGDGKCFSCGKEGHRARDCFEGGDKRGGGDHGDRRSDRKDRDRGDRGDRGDRGDRGDRGDRGDRDRSPRRDSGRDRERRRPSYRDREDRGRSPHHSDRRGQDRREERGERDSRKERSPEKEKTDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163E870</accession>
    <name>A0A163E870_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_60388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295300.1">
        <property type="nucleotide sequence ID" value="XM_018440635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163E870"/>
    <dbReference type="STRING" id="763407.A0A163E870"/>
    <dbReference type="GeneID" id="29001541"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_60388"/>
    <dbReference type="InParanoid" id="A0A163E870"/>
    <dbReference type="OrthoDB" id="2534759at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00014">
        <property type="entry name" value="CH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702:SF1">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="209"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD77260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="516" mass="58637" checksum="505696E15E0589D0" modified="2016-07-06" version="1">MFQHPLDVAPNDELAEEPNHSLLTEEDNLMPQWHHSIPDLHSHDYVVRSSSPFGRRYLKPVHGIQTKGFARSAQRRSSVLTLGSIERLQHFYAKRELQVNKLGTLGFKVVEEPDEFDDLPTPKAPPPSWIDLDVETDLDVLLEVCFNDIQSTLTTWSMVTGPHLVHETASDSDSDGSFQILPLLSSVTKMINAVKNYTLNRHDLSDSAMSKLRHASLNLLESMRELENQHRMEVDEEEDNRSEDGYIYRTSDFNMLEKERLAIDAYLETVEKYGFNPPHHIGSPPAMFTPEIKALMNRSSFLGGSSTSTAGSTDTQTAAELDLVQKRAQNGRSLGIPSWLERGSFAGDDMGRYYALLKDNRQSAFEADAGTEVLIPDPHEDEDAFLQSLVDGITLCNTYNNIVKRSRRPFGFINKVHQDTRRTYRAIENLRFFSAACKFRFDLQFDAFDPSEIARKTDRGLSMIKTTLKAFCDCVIREMRENADMASKRSLPSRPPLEDTISEYMEKQLFISQDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EAM6</accession>
    <name>A0A163EAM6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">UV-stimulated scaffold protein A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_60800</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UVSSA family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295710.1">
        <property type="nucleotide sequence ID" value="XM_018440700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EAM6"/>
    <dbReference type="STRING" id="763407.A0A163EAM6"/>
    <dbReference type="GeneID" id="29001606"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_60800"/>
    <dbReference type="InParanoid" id="A0A163EAM6"/>
    <dbReference type="OrthoDB" id="5594015at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018610">
        <property type="entry name" value="UVSSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049431">
        <property type="entry name" value="UVSSA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049408">
        <property type="entry name" value="UVSSA_N_a-solenoid_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28670">
        <property type="entry name" value="UV-STIMULATED SCAFFOLD PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28670:SF1">
        <property type="entry name" value="UV-STIMULATED SCAFFOLD PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09740">
        <property type="entry name" value="DUF2043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20867">
        <property type="entry name" value="UVSSA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UV-stimulated scaffold protein A C-terminal" evidence="11">
        <location>
            <begin position="468"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="359"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD77670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="669" mass="77050" checksum="472438FD0667DAE3" modified="2016-07-06" version="1">MNDQIEETLERLIKQITETGEWELDPQILKLIKKLCKQSNANVDVAFYIIWNQLQKKQSQIRYSCVQLIEVLFFRSHRFRILVANEFQSFLRLTVGINRQPLPPPVQDQLRRLAISLVKSWNQKYGRVQRQIANGYHFLEYRNLLDENSSGSLAALSLSSSASASASASSSLSYTRTRDQNKANVQSRMKAIQERRVDQIKTEVDDYLKIIQENIITMDSCFLILVPKNSEDELDFDALIKGDLDSLKVPDGSYRERILSHGLGSSRYKITIDLSESSVMEDIHETPENTIVYEQLRQGLKLIEKKHAKQLNDWIKVLKKESLLKQLIDVKVDMTEALRKCRLLGITIPEFEDPEKALKNKTKIKPKKNQQRNQNEDEDEDEEFGDERFEEIDVPKQGLDVEKNPLTVDSRVLPPAQRIFPLAYEPGMSEDITYRGAFVSPHKTLTGPTGYKEKGKQKEDSTRQELLKKAPVVEWGEDLYYWDKTHVQFNTSGLEKNHRFMGTGEGVNELPASLLDELRKRPRYYQESSEPLRACGAPLHNGGLCPRRDLVICPFHGKIVSRDSIGQPLDPAEAPKVQVLQVPQSGTSKEFWEDIEGEVMVQTGQEKIESGHKKRKRDHKSALVDVRQNKPKSFHRRLQDKLDTRAIRRSVEEAVEYERTQKSRLKKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EQF2</accession>
    <name>A0A163EQF2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_73769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298880.1">
        <property type="nucleotide sequence ID" value="XM_018442911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EQF2"/>
    <dbReference type="GeneID" id="29003817"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73769"/>
    <dbReference type="InParanoid" id="A0A163EQF2"/>
    <dbReference type="OrthoDB" id="10523467at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="285" mass="32694" checksum="11C5A79C22A47045" modified="2016-07-06" version="1">MSDINTTLLNSIQKIEVDLAEIKQALHELQRQFSNQFAPAVSAEDLTTMQQSIIEQSSLERIAESVKRAQLTEYPDQLGKQVLNTGGKFKGKNKAQKYNLLLQILHEQDWKARCKEVPKGQPLPPLVPLSDHDLTVKRLHLKTLGCTVKHDIIDKDYPAASKEWKNIPEKNREYYMMHLERLTKNGGLHIHQCKRMRCARSLLRESFKSDNQTHKRRMAEKNKTQRDISDSLLSSSDMSETGDVESPIMADVLSPPPTASVEPARKRSQRSVNAYFTEQYICRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JF17</accession>
    <name>A0A167JF17_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_189490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441027">
        <property type="protein sequence ID" value="OAD65867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018439670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JF17"/>
    <dbReference type="FunCoup" id="A0A167JF17">
        <property type="interactions" value="349"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167JF17"/>
    <dbReference type="GeneID" id="29000576"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_189490"/>
    <dbReference type="InParanoid" id="A0A167JF17"/>
    <dbReference type="OrthoDB" id="1049195at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF3">
        <property type="entry name" value="FI21236P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="112"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="203"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="381"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="280"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD65867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="461" mass="52451" checksum="37D093A2986E2923" modified="2016-07-06" version="1">MSERSRSRSRSKSPKREPLSPTATKHVNSARGEDDEDERDRRHRTPSPRRGHHRSYSRSPSRSPHHRRSSSRRRHSSRRRYASRSPHRSSRRYSRSPPPRKARTGPSQPKECRVYVGNLSYDTKWHHLKDFMREAGTVMHADILTLANGRSKGCGVVEYKHPEDAQNAIRLLHKTEFMGRPVFVREDLKSETPGSTKEAPEECQLFVGNLPYFASWQDLKDLFRKAGRVRHTDIVTDPETRRSSGRGLVIFDDPQDARSAIEMYNGYEWQGRRLEVCEERNRPPPRVSGGNESRGSGQALHRDSGRERSIENYRSSKDVSAHVSHPPPPPPISHYGGDNYDNSYRYQDGGAPHAVLPMAQMPHQMNVVGGPGASLPSIGANQIYVKNLPYSTTWQDLIDLFRHVGPVVRAEILLSGAHPKGSGLVRFEDFQTCERAIDKFNGYLYGGRHLDIRLDRQSTCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JWE3</accession>
    <name>A0A167JWE3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_189191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441000">
        <property type="protein sequence ID" value="OAD66809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284849.1">
        <property type="nucleotide sequence ID" value="XM_018439618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JWE3"/>
    <dbReference type="STRING" id="763407.A0A167JWE3"/>
    <dbReference type="GeneID" id="29000524"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_189191"/>
    <dbReference type="InParanoid" id="A0A167JWE3"/>
    <dbReference type="OrthoDB" id="2272461at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="523" mass="57094" checksum="C118F8D9F589B37D" modified="2016-07-06" version="1">MDPSACPQPQDNYSAGTPAQEDCSTLSPTLADILSDDRILRFYQCVKDIKTQRSPKQTAAMFFALCHALGDTVSFLKVPNMSKIIFRQEQQIFAVNVAGTQHDAVQLFHNTGELPALDPLKMDNGPILHPVEHQNLFAAPDTTKRAKKASPRDKEYAVRRNELIQDLLKVPEADLLHQANIVDDDIKLVIQGHERSTKFGVLPPLHRFATFANLPAHYDCDFAPKNAGVYFNFEYFQLYLAYRDLELERQQQQQQQHQQHIDTSDHRPVLVQCRADIEKVLVNTNWEAIRRRLTIGERICQVCGAFGRGFLLLSKQVSGRKLLHNFNTGEWSEFMREFQHPESQALLQTLQAKYSPERFYGTRPVQALHDVHSVIASANSSSSGASSSGAPIPASPSASSGAIVVVGPSSSSSSSSGPGSGSGPGSGPGPSSTSTSSNVNHNHNHNHNHNNNHNHNHSHNHNSNNTGANTPVGTSTASSANPNPNNNVSNPSPISTTIPSSGPEIARVATPLSTPVEPSTETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K6J2</accession>
    <name>A0A167K6J2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Letm1 RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_11609</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285410.1">
        <property type="nucleotide sequence ID" value="XM_018428499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K6J2"/>
    <dbReference type="FunCoup" id="A0A167K6J2">
        <property type="interactions" value="393"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167K6J2"/>
    <dbReference type="GeneID" id="28989405"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_11609"/>
    <dbReference type="InParanoid" id="A0A167K6J2"/>
    <dbReference type="OrthoDB" id="275278at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="9">
        <location>
            <begin position="103"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD67370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="332" mass="38299" checksum="8951B5BBA2D85236" modified="2016-07-06" version="1" fragment="single">KKTLWQKVKAEAVHYWHGTKLLGLEVRISSKLTWKLLHGNKLTRREARQLRRTTSDIIRLVPFAVFLIVPFMELLLPVALKLFPNMLPSTYESKTVEEEKKRKLLKVRLEMAKFLQETIAETGFPGSDSSQAAQEFAEFFRKTRITGEQPSTEDLLNVARRFEDELTLDNLTRPQLVSMCRYMNINAFGSDNFLRFQIRNRMRQIKADDQVIVAEGIDDLTIQELQAACAARGIRTIGTSPGRLRDELSQWLDLHLNHHVPSTLLILSRAFSFTDRHMTTEDALRVTFDSLPDNLVNEAELQVLELVGASTYKQKMEVLEQQQELIEDESEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K8E1</accession>
    <name>A0A167K8E1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_151386</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285516.1">
        <property type="nucleotide sequence ID" value="XM_018432674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K8E1"/>
    <dbReference type="STRING" id="763407.A0A167K8E1"/>
    <dbReference type="GeneID" id="28993580"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151386"/>
    <dbReference type="InParanoid" id="A0A167K8E1"/>
    <dbReference type="OrthoDB" id="2152896at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD67476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="196" mass="22448" checksum="3B0AC865601F16AB" modified="2016-07-06" version="1">MPSQANILLRQQPKYQKQEQQVEEALHRLPSPPTSSCGDDPLTNTRDISDSRRGSLPTHFNVMTLQRFSTSLPENYTIDHSLAKSRPEPLEKTLVSTPTNTTNTTGIKIRQRRPSEGYRKARLSAEPKNYQAHRCDACGKVYKHLNCLVKHRWEHSDEWELTSKFLLTKHQQVQMLEAAAILVSMDNSSYSPFKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KGW5</accession>
    <name>A0A167KGW5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T2</fullName>
            <ecNumber evidence="2">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_69141</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19" evidence="2"/>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286106.1">
        <property type="nucleotide sequence ID" value="XM_018442056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KGW5"/>
    <dbReference type="STRING" id="763407.A0A167KGW5"/>
    <dbReference type="GeneID" id="29002962"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_69141"/>
    <dbReference type="InParanoid" id="A0A167KGW5"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018188">
        <property type="entry name" value="RNase_T2_His_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00530">
        <property type="entry name" value="RNASE_T2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007889400" description="ribonuclease T2" evidence="6">
        <location>
            <begin position="19"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR633697-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD68066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="264" mass="30129" checksum="095519CA4A5AF940" modified="2016-07-06" version="1">MLRSILGLILTSALTATAFQASQQVFQEEDYFEQNLYEAPSCNNTLLSCHWNGRVDSCCTPKYGLVVLTLQWVPGFGPDKEFTIHGLWPDTCSGGRAPGNGCDRSRVANNIGNIVRDMDPSLHSEMSTFWPSYKGDNNWFWSHEWNKHGTCISTLRPSCYGKEYTKYQDVTAYFKQALELRHYYDLFGALNLAGVIPGQTYNVQTMIEPLEKYVGAKIKMDCDRKGQLSEVSMFFYVEGRDKYKITDAFQKGNCRGAVWYPKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KJ72</accession>
    <name>A0A167KJ72_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 20">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="14">IMP dehydrogenase</shortName>
            <shortName evidence="14">IMPD</shortName>
            <shortName evidence="14">IMPDH</shortName>
            <ecNumber evidence="14 20">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PHYBLDRAFT_75347</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14 20">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14 20">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homotetramer. Seems to be able to form heterotetramers composed from more than 1 of the 3 IMPDH gene products (IMD2-4).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14 19">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="14 20"/>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286266.1">
        <property type="nucleotide sequence ID" value="XM_018443052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KJ72"/>
    <dbReference type="FunCoup" id="A0A167KJ72">
        <property type="interactions" value="379"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167KJ72"/>
    <dbReference type="GeneID" id="29003958"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_75347"/>
    <dbReference type="InParanoid" id="A0A167KJ72"/>
    <dbReference type="OrthoDB" id="416622at2759"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000007">
        <property type="entry name" value="Chromosome 19 SCAF14664, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 20" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5 14 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 14 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 14 17" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 14 20" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="21">
        <location>
            <begin position="121"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="21">
        <location>
            <begin position="184"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="14 15">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14 15">
        <location>
            <position position="438"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <begin position="278"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <begin position="328"/>
            <end position="330"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14 17">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14 17">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14 17">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="368"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="391"/>
            <end position="392"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="415"/>
            <end position="419"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OAD68226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="524" mass="56057" checksum="C45D608E439ED6EF" modified="2016-07-06" version="1">MSNVIDFSKAKDYLKTYGNRDGLSVEALLDEQLSGGLTYNDFLILPGFIDFAAEKASLESKITRNITLKTPFLSSPMDTVTETDMAISMALLGGIGIIHHNCSPEEQADMVRKVKKFENGFIIDPVVLSPTNTVADVKAIKEKSGFCGIPITETGKMHGKLVGIVTARDIQFHQDDSSSLKDIMTKDLVVAKEGVTLTEANNILASSKKGKLPIVDSQGNLVSLLARSDLLKNQNYPLASKAPDSKQLLCGAAIGTRPDDRDRLELLVNAGLDVVVLDSSQGNSVYQIEMIQWIKKTFPKLEVIAGNVVTREQAASLIAAGADGLRIGMGSGSICITQEVMACGRPQATAVYRVSEFAAKFGVPTIADGGIGNVGHIVKATALGASAVMMGGLLAGTTESPGEYFYREGQRLKRYRGMGSIDAMNNKSGKDGNAATKRYFSEGDAVKVAQGVVGNVVDKGSVRKFLGYLHTGVQHSLQDIGCRSLAEFHESVANGTVRFEKRTAAAQMEGGVHGLHSFEKKLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KWR9</accession>
    <name>A0A167KWR9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_150063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD69066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287106.1">
        <property type="nucleotide sequence ID" value="XM_018432388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KWR9"/>
    <dbReference type="FunCoup" id="A0A167KWR9">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167KWR9"/>
    <dbReference type="GeneID" id="28993294"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150063"/>
    <dbReference type="InParanoid" id="A0A167KWR9"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="87"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD69066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="310" mass="34446" checksum="F210EEEC878CB338" modified="2016-07-06" version="1">MSEIVHPTTNPSPMPSATHSSGGSSGANWKMSADGRIYHNVESSAYILPQDEEEQDRLNSQHFAAKALSNGNMLASVVEALPQEAKILDIGCGSGSWVMDVAIDNPCTHITGIDIADIFPAIIRPKNADFKLVNVLDGLPFPDATFDFVHMRLLIVAFRINEWDKVIDEIYRVLKPGGLIQLVESQYTDTEQSPKIHRFVSALLSLMADKHQDPLIGSKLEGKVIAHGFELMQKERIRIPFSNPQNAVYAELLWGWGNAMKALKQALAPRLCPDNESDYDQILNEYLKDCADFGWVVYIWSVAGRKPLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L5G8</accession>
    <name>A0A167L5G8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CSN8/PSMD8/EIF3K domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_159816</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287678.1">
        <property type="nucleotide sequence ID" value="XM_018434064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L5G8"/>
    <dbReference type="STRING" id="763407.A0A167L5G8"/>
    <dbReference type="GeneID" id="28994970"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159816"/>
    <dbReference type="InParanoid" id="A0A167L5G8"/>
    <dbReference type="OrthoDB" id="5351233at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010387">
        <property type="term" value="P:COP9 signalosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033205">
        <property type="entry name" value="COP9_CSN8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13339">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13339:SF0">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="CSN8/PSMD8/EIF3K" evidence="6">
        <location>
            <begin position="41"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD69638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="196" mass="22467" checksum="317D1437DA30A7BC" modified="2016-07-06" version="1">MEVILPFITEKNYNGLIETCEQLELKHAAGQSNIDLSDIDATYLIGYCLINDLDSARFLRKRILARDNVRRPEVDFAWKVCAALWDQRYSDFYSALHDFPWSDPIQSLVASLQENTRERMLVTVANAYTSIKISDALYYFGMPENELVTALLSKGWTYDSSSKILTPNKPELKIQDISSNDKFSSLAEMILHLEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L778</accession>
    <name>A0A167L778_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdopterin synthase sulfur carrier subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_182606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287787.1">
        <property type="nucleotide sequence ID" value="XM_018438648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L778"/>
    <dbReference type="STRING" id="763407.A0A167L778"/>
    <dbReference type="GeneID" id="28999554"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_182606"/>
    <dbReference type="InParanoid" id="A0A167L778"/>
    <dbReference type="OrthoDB" id="5595860at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990133">
        <property type="term" value="C:molybdopterin adenylyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00754">
        <property type="entry name" value="Ubl_MoaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044672">
        <property type="entry name" value="MOCS2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33359">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE SULFUR CARRIER SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33359:SF1">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE SULFUR CARRIER SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9672" checksum="C85B601365734F76" modified="2016-07-06" version="1">MAYQITVLYFAAARDITQRPSETLTVDSDWTLARLTEKLVDMYGSPLEKILGTSMYAVNMDYVSSSDVSTTNLKPHDEIAIIPPVSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LP75</accession>
    <name>A0A167LP75_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_170916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288874.1">
        <property type="nucleotide sequence ID" value="XM_018436448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LP75"/>
    <dbReference type="GeneID" id="28997354"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170916"/>
    <dbReference type="InParanoid" id="A0A167LP75"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="163" mass="19229" checksum="DA87B2D9D51B9606" modified="2016-07-06" version="1">MAVSAIANWLNNQNSTFFHVKFKYHAFTWVDISYIYQFRVIFKATHLKTYMIGYAGKNPKLEALYIKEKTQKDQTYELKTKLLCEDMLESIGTPAFDPITSRDYEHTDMMNLDHYSDREGLQQACYSGQRQYYSSVQWSKMIRSLITNMNQNIGGYLIRMLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LWV7</accession>
    <name>A0A167LWV7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_170631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289294.1">
        <property type="nucleotide sequence ID" value="XM_018436389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LWV7"/>
    <dbReference type="GeneID" id="28997295"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170631"/>
    <dbReference type="InParanoid" id="A0A167LWV7"/>
    <dbReference type="OrthoDB" id="2299910at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="238" mass="27331" checksum="83D4E5E65EAF4243" modified="2016-07-06" version="1">MTGIFNFNTTVKSHYQAPSSIVHVHSPDIDERWDTFLDSQQRTSKHVQCPIIYIQPHQLHSIDILPASPKEYNDNDNDNDNDDDNDDDKIQNLANKTIDYFAHPSESLLDNYDTTPDIQEISTDDDDDDNDNDNDDYDYAYDYEEVQVKSNDDDDDDGQSDLCCSEDGAKIETIVRPRSQKSISVEAYHRMMAQRYTARLLKIASVCQTSEINLPLVYQKQLDSLQTPLLPPPSQYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M875</accession>
    <name>A0A167M875_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Gluconokinase</fullName>
            <ecNumber evidence="3 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_113820</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-gluconate + ATP = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate acid metabolism; D-gluconate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="3 9"/>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290134.1">
        <property type="nucleotide sequence ID" value="XM_018428358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M875"/>
    <dbReference type="FunCoup" id="A0A167M875">
        <property type="interactions" value="742"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167M875"/>
    <dbReference type="GeneID" id="28989264"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_113820"/>
    <dbReference type="InParanoid" id="A0A167M875"/>
    <dbReference type="OrthoDB" id="275177at2759"/>
    <dbReference type="UniPathway" id="UPA00792"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442:SF3">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD72094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="185" mass="20630" checksum="FBD5311B97119B22" modified="2016-07-06" version="1">MPIFVMMGTAGCGKSSVALEMESRLGCLFIEGDELHPASNVQKMANGYPLTDEDRLPWLRTIRDVLLEEAKKRYTHQATSDASRIGAIVTCSSLRKIYRDILSDIPSHLATVTFCYLKGSPELLATRIAARQNHFMKPGMLQSQLQALEEPDSTKERVIVADIGFPIKEIVDSIMSQAKERHLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MHH1</accession>
    <name>A0A167MHH1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_169118</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290896.1">
        <property type="nucleotide sequence ID" value="XM_018436008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MHH1"/>
    <dbReference type="FunCoup" id="A0A167MHH1">
        <property type="interactions" value="416"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167MHH1"/>
    <dbReference type="GeneID" id="28996914"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169118"/>
    <dbReference type="InParanoid" id="A0A167MHH1"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF147">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="16"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD72856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="536" mass="62035" checksum="894B2183D03116E5" modified="2016-07-06" version="1">MDEYLDWIARNGGSYSKLDFRRDQETNGTVHATETVYPNDTFATVPFRVTITEKVARKTFADLSDVSCRNVMALFVAYQSLLGDQSFYAPYLNILPKQILTPFFWETEDLHYLDQTNLATAVRERKLNIFNDYEALVVRLSAELPFPYTLIDPTHTEPSEVLFPLVDSLNHKPNTKITWVRSGDDQSGSLSFVSGQVFNAGEEMFNNYGPKSNEELLLGYGFCFEVNEHDHVALKPNFSRDPNGQVKLEILKQCHIESGNPDPLTYYVHREHIPQMFLKLMRVLVMNQTEAKIYIQCKDSQQLEWVGYRNELAMVAMTCALLQSRLNAIRAVELNRETTRWVQRCALMYRDGQEQILALTLISMENLKQTIFKKMARDKKQERIAPVTPFVNYLNPGYFESLTYPDLEAEGLVMMDSVTITLGQLLRDKKFKSTIEQLFEDIEEEEDVVWMIGLLHERTKKNSPWKPFFEKTEKAYLQEHQNLEELEDLHGSLFPAFSEAFPDIFAPQDYTVQLFGWADMVMNTYTIENPLCVVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MJE3</accession>
    <name>A0A167MJE3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_169261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD73004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291044.1">
        <property type="nucleotide sequence ID" value="XM_018436028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MJE3"/>
    <dbReference type="GeneID" id="28996934"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169261"/>
    <dbReference type="InParanoid" id="A0A167MJE3"/>
    <dbReference type="OrthoDB" id="10380402at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007890374" evidence="2">
        <location>
            <begin position="20"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD73004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="237" mass="26308" checksum="AFEB11C466AAD79D" modified="2016-07-06" version="1">MKIYFLFIGLLLGFETVFAIYNNREEFPDIDKSYIPLRYAYDDVIQPADMNTLSRIPLDENTTAVFRFTQRGESVTYNLYLEGYHAKSLCISWIVGVSYVDSSDPAKCLYKPTSKCMDSVESGKCVYGTKDLGDCHSGDGIEGTAVHKSTNATSMLVKSGNSTLLSLIDDYDSSISKRSIMVNYFFYGQKAPKRACGVLLLGAVKEETYTPLNSGIRVAPVYITGVAFLLAYLILLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MSN3</accession>
    <name>A0A167MSN3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_168240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291849.1">
        <property type="nucleotide sequence ID" value="XM_018435825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MSN3"/>
    <dbReference type="STRING" id="763407.A0A167MSN3"/>
    <dbReference type="GeneID" id="28996731"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168240"/>
    <dbReference type="InParanoid" id="A0A167MSN3"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818:SF3">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="476"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="971"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1143"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="971"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1081"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1162"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1172"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1229"/>
            <end position="1243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD73809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1276" mass="142175" checksum="D11D20B086F30F73" modified="2016-07-06" version="1">MTKELDDHQENSPNEDTEIKGKTPSKENIEEWATFDQELQAFDSNISSHSEYLSASSQSNTDQYQSSYNFLQPSPDNESPKNVASDRHLDVQHSSPAPSQIPQIKPRNPLRIDTSRAGVPRINAVRADVALNRSESDPTDRKGKRPLRQVLNWAPSGSNPIKHRIPSVTSNPLTSGPYSNLCASQNDSDALARQARIRKAHMASAAAECMVAAAKVAKARKIHAAADPSSVSSPRKNNSLQEVPSGSQSVAEVPEWSDSDTVTDSKTNSLESSPIHTPRQDDTLPKSPVSDTHGTLEIPVESYFEFSPEALGQAIVMEVDNRTIQRIVDRVLADAALRYSSEPKEIVVDKSVAFIDPVDKQVEETHQKCEVSESPKEMLEVFDLSPSKDPISTSEACDTNTIGVVKPSNISQHNKGNSVRSHSSQVSNENPKLLRNSGSTNSGTKVPSPQEKVEEIKENDEATLLKMAFESARTNKRMSAIKELLETEESYAKKLSNYVRHFLFPIQQKNNIPDDKKQILLRNCSQIHRFEEDFLVALQSAHMTKQSTLNGHIHTGNIIAIARCFIEWGPRFEVYIEYCVNHDDAYLLYKELLETSDDFSKMMAQLHAKNPVAFRGSRLTMTDYMMMPIQRLLRYRILLQTITKATQKDTVEYEELSKAQDAMHKIASRIDDEKARVQAVKKTGMFLSRIESDSSLPERWYNALGVCVLIGTLEVRSDTNSMRIKRLGCALFDNYMIIVKGKKPKRYQLQYWFPLRIFTVDPNGGLDHGWTMLSDRYTFDFGSVCEQERIIWVEALGKTIEQSKVRYEQLQEEDCLEHLFGSSFDIERPLHRRASTVHSSNSFASISSLASHKSHKSLSEAARMEADTILHSTIDETSIKSHSSFHDIQEFFANSVSGKWGYSKQVQVTQNQQAIDHRFEDVCTTPLLKARCQAIQDRASTFSSWRHRSYVSKTPSVLSFRHIEENGYFGSASSSVTSSPHPLPSSNRATPVATSPQYRNFGDGLMSAIQRKTSLPIRPSVSTPKEKKMGHRQAMPPPPTPQRPQAIQNVSLPCAYDDENSLEKASQKKSMIFKLSQRPQKPVERSGGDKESSGMSRVPSAIFGKLAVRLGNLGAPLRQRSHASSSTTSVNVMALSLSSSECLEHTEGDNSGSFEKKKQRLSRLALSSRSSTMEQKASSSTKSVISQATGHSGLPPLPSSNTSLKLSVESRRSSKSGIVSSPDIQETGSTRAESCESGSSSNSLPITNTTEPRRFKNLRTRLFEFASPLQKRNKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MV64</accession>
    <name>A0A167MV64_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_144575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292159.1">
        <property type="nucleotide sequence ID" value="XM_018431244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MV64"/>
    <dbReference type="STRING" id="763407.A0A167MV64"/>
    <dbReference type="GeneID" id="28992150"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144575"/>
    <dbReference type="InParanoid" id="A0A167MV64"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD74119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="55935" checksum="5B70337AACAE58D4" modified="2016-07-06" version="1">MEVNRNIRWTSTGRVLYITLGLSYLQLSLAQTFYRPLPRWAAGCGLIPGTLYCYGGEESPGRRLNSLLALNLKKPWSITAPEWREVPFKTGDTSDDVLIKQPGNLLTEPIPMSYFDASSLPDGYRIVTNGGSTVDAAGLGLRTLIYDTKTNQWSAPMYGKAVKSIGRRRKQHTSTIDAHGHIWMWGGTSDNTTSIGPTVYYDSWVMVDSNTWTYSYPIPQNAPPLPRIDHSATLINGNQILIMGGMTYARNVTDPDGNFALNPVSMGTLLVYDIVSSRWSNISAGGNIPAPRRGHSAVLSSDGLRVILFGGGRPLLGSKLDSDEVFNDVFILELDTMRWTAPFIGGVPPTPRKYHKDDLMLIVFGLDVSGKGSSDTGILSIAAGSWITQYTPNNLLSAGGSDGSGLNGQGRPIGPYGSYANHYSNIKAGIVAGIICAIVIMMCGSSVVLFGMYLYRRKKTYNENASSNAIDPETYGHVKYALPNEIKSSSILHPRSPQLTQDNYDKPNEQSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MZK7</accession>
    <name>A0A167MZK7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_186839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292644.1">
        <property type="nucleotide sequence ID" value="XM_018439290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MZK7"/>
    <dbReference type="GeneID" id="29000196"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_186839"/>
    <dbReference type="InParanoid" id="A0A167MZK7"/>
    <dbReference type="OrthoDB" id="2289862at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="273" mass="32699" checksum="AF05A2A76CB8D14D" modified="2016-07-06" version="1">MPPIYWDTFFASSMHMAHSQPKSRRPKRTRSCDEMDGQINQSKRSRTNNTTNNGSNNNSIYLQEPEERHFTEAQRTENYRQPPLILEQQHQEGEDDDAQRHSQLQLQLQLHLQQQQEAQQHLQSQLQEQEQEQEQEHEQEQERQIHNHQHYHHSQSTNNQGRLTQQQQQQQHALHHRIQQLQQEQSQNYLQSTSSSFQPPILKSFVISTRHTPPNTAYREMNELLHTTHVLRHGDETRERCWVDKMDDEMSDVESSYEDINSVLRQAFLQRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N0D5</accession>
    <name>A0A167N0D5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_61280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292704.1">
        <property type="nucleotide sequence ID" value="XM_018440783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N0D5"/>
    <dbReference type="STRING" id="763407.A0A167N0D5"/>
    <dbReference type="GeneID" id="29001689"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61280"/>
    <dbReference type="InParanoid" id="A0A167N0D5"/>
    <dbReference type="OrthoDB" id="5573160at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="619" mass="68335" checksum="BEE00F29D4D609C7" modified="2016-07-06" version="1">MSTHQDSEPNNMTEPSNDSEQLAIIDMNFPLQPLYDRLLSLSFTESVKAIEHCRDLCAQFGFTVKQEASTHRNIYVYCSREGVPDSLRKRGATPQRKRPSKRCDCRWRVVLYEKEGRWEFRKSQNPDAAKHNHELMRPDEIERNWPKAVIDMICELARQRLTTQEIRTAVKDQFTTISWNERRFYNRLSEERQKIKHREAATRARNLTELWTKVCMAAAGNEELSRFVETEATKILATICQTIQLEPDTLRPPTEIAEETVELLAVVNPTPVENDEPEGSNRAGNRTGENNARGRRATSQQLPVDSEDNTRPPENPPSSVKTNRQGSGTNTTKPPEAPKGYTSVIVPRHTYFVKLHSLRTIGELNIARNSIVAREGSTADESGSETVSPARRVLKRTRDGTLVDQTPGPADALHALQQQQQQQHTFLAGTHPHRAHPMPPAPVPQTMHQGPSSSSQAPFVYHPTYDSHGMPIGAPLPNYVHSTFYHHTMPPQAPNNGYTPNSDLNFHFNTSHGPMMRQHPQAGNSNSGGSGSGSGSGSGSGSGSGSGSGSGNGGGSSSNDNREQHGPHSGLQPNNMIQGKAPSSTPTPTPSAPPSNISNQPHHHAIQTLTIIHHQPPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N3B5</accession>
    <name>A0A167N3B5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_167210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292910.1">
        <property type="nucleotide sequence ID" value="XM_018435596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N3B5"/>
    <dbReference type="GeneID" id="28996502"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167210"/>
    <dbReference type="InParanoid" id="A0A167N3B5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="268" mass="29895" checksum="B4CECB240C5E71BB" modified="2016-07-06" version="1">MIYLMKYQIMAPRTNINQNAHTNRSASRPLINTVNTGCIGSSNPMIAPTPDNMSIPVSEFNDVVSILATLNNKMTAVSSDVSELKVQCQVGAQSTGMQAVLDSDMDPQDIISSSRHPKISLIRENNDKPTWDVNVGLSDEFNKNLATAMVPPKELCGIIVNSYYNCLAASKLTEEDIQTNTTSNRRGNRKTALNKRRKRTYKKHKDAVTKKFNRDYNGVFYRDAMSGDETETDTSVVASRSDWRSNELNAVFDFLDNLARDDLGKRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N9X9</accession>
    <name>A0A167N9X9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_158404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293480.1">
        <property type="nucleotide sequence ID" value="XM_018433781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N9X9"/>
    <dbReference type="GeneID" id="28994687"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_158404"/>
    <dbReference type="InParanoid" id="A0A167N9X9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="59" mass="6678" checksum="9157EF0126494C87" modified="2016-07-06" version="1">MSLTTINSSLLRTLFGIYIFIAILSFAQAVSFVPRGYFTDKTVEPTYTKDQKDDVLINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NWQ6</accession>
    <name>A0A167NWQ6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_157999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294814.1">
        <property type="nucleotide sequence ID" value="XM_018433713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NWQ6"/>
    <dbReference type="GeneID" id="28994619"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157999"/>
    <dbReference type="InParanoid" id="A0A167NWQ6"/>
    <dbReference type="OrthoDB" id="2286412at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="185" mass="21094" checksum="9A1DAD92E74EF56B" modified="2016-07-06" version="1">MSAVLADVEQNRVFSWTNTASTGTENEHPDGEMATINQRSIAYHLGYCEVKVSEGDSSSVYLHYDMLRLARFGKKLCHNEDLRGSLLVMAVGFRVRFFILTRNKPFDTMFEIANMELPKSLSTLASFTSNVHKIKQILQAYYTHCTKEPEISLKRKKESSMTKNDIQQVINTSKPKKMKASLSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NY51</accession>
    <name>A0A167NY51_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_165367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294904.1">
        <property type="nucleotide sequence ID" value="XM_018435216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NY51"/>
    <dbReference type="GeneID" id="28996122"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165367"/>
    <dbReference type="InParanoid" id="A0A167NY51"/>
    <dbReference type="OrthoDB" id="2289822at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="245" mass="27164" checksum="67E6ED2ECAB65981" modified="2016-07-06" version="1">MSKDGCHICHVVGQSSGHGQYFRMPSTITMRTPESFKYFDEVALSSKKGLTGQSPFSLLNSFSGPFFFALDEMHGICHSIAKQVWGLVCGKYGKDHPLSLSLAAQKEIGTAMVSTRRSIPTSFHGAWINVATRSGYFRAVDWADFILFVIPTLVAERVCDQAARKALLDLAYYCEYSAFYSGVLPISTGTKADLVTCAQTCYLQVVPRKLYFKLCFFAVIQSVSMLKVNNQGLRRMCIVELSLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P065</accession>
    <name>A0A167P065_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_165483</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295026.1">
        <property type="nucleotide sequence ID" value="XM_018435246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P065"/>
    <dbReference type="STRING" id="763407.A0A167P065"/>
    <dbReference type="GeneID" id="28996152"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165483"/>
    <dbReference type="InParanoid" id="A0A167P065"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044834">
        <property type="entry name" value="PATL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45932:SF17">
        <property type="entry name" value="CELLULAR RETINALDEHYDE-BINDING_TRIPLE FUNCTION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45932">
        <property type="entry name" value="PATELLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="5">
        <location>
            <begin position="88"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="271"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD76986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="353" mass="40165" checksum="0183F2770F4887C9" modified="2016-07-06" version="1">MENSFVKAMLPTEIKAIDELKAKLPEITKEALDTEEPYVLWNVPLDSTSTDERLNVLLCKFLRARELNVDNAATMLTNTLKWRKEFKTDDILDETFDQEVYGSLGYLHKHDREGRPVCYNLYGDIDQDKVFANPDTFIRWRVQLMEKGVRSIDLVKVDSMLQVHDYKGASMFGRSSNAKAATKEIIAIMQDNYPEYLSTKFFVNVPWWGSMIFQMVRPFLPEATVKKFVVCSSSEIFAGLTTLIDAENLPDRYLPVVATKEVQETPVQKVVVEEESQSVSGDKTSEPTAFSSKVQEDDKEEKEEVKEPDTSKVDVPTKDITESQLDIEVLPTGEPDEPLSSRKDEKKPANSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P657</accession>
    <name>A0A167P657_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_60453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295364.1">
        <property type="nucleotide sequence ID" value="XM_018440644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P657"/>
    <dbReference type="GeneID" id="29001550"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_60453"/>
    <dbReference type="InParanoid" id="A0A167P657"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="101" mass="11558" checksum="D2A5F5BA0007304B" modified="2016-07-06" version="1">MSGMLLAIKVAKTQLSCAYGDLNTAIYHSVHFPRQRTLINLSLSQLHTNKKFLEGRYSLLYNSVIVGNIRIRRRYTNSYISYDYGVIKSVIYYSGIQVMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PFH4</accession>
    <name>A0A167PFH4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_164697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295849.1">
        <property type="nucleotide sequence ID" value="XM_018435061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PFH4"/>
    <dbReference type="STRING" id="763407.A0A167PFH4"/>
    <dbReference type="GeneID" id="28995967"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164697"/>
    <dbReference type="InParanoid" id="A0A167PFH4"/>
    <dbReference type="OrthoDB" id="5592486at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="147"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD77809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="484" mass="54489" checksum="CFE35EE47ADA1F00" modified="2016-07-06" version="1">MVAISFCVFYNYLQTALVSSSSNISSLSVLLKQVPHKFLSFQTSATNDNNNNLSSTKNNKNNNGQVLYPRRLKQQEPNKGTFIFDTITASDFFSQSILTNTTITKDTNNNKNDDSILTTTIKPNDNINLVTGLDMPVTPHYVAPRAPIVLCHGLYGFDLWGPDAFPALQFHYWQGIEDALAKLGAKVIVTGVPKTGSIRERAQELHAVLKAIMKDKDVNFVAHSMGGLDCRYLLSHIKDRPYRPRSLTTICTPHQGSPVMDWFRDHVGVGEQKPGNPCNQRSLSAMTVSMKNSVTRTEEFATASMMAYYNHHHNNNDDDDDLHVPLSDRQNKTQSQTQTQTQNQKLLNLKLKLGLLPKAMIDYFDEPAYGNLTTDYCQEFFNPNTPDDLGVQYYSYGAAAKIPAWSSLLSTPWQIVKDKEGDNDGIVSIKSAKWGKYIKTVEADHWDLSGKSCIPYRWQSDSSSTFDREAFYLEMATRLYHQGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PIN3</accession>
    <name>A0A167PIN3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Golgi pH regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_79150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD78016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296056.1">
        <property type="nucleotide sequence ID" value="XM_018443435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PIN3"/>
    <dbReference type="STRING" id="763407.A0A167PIN3"/>
    <dbReference type="GeneID" id="29004340"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_79150"/>
    <dbReference type="InParanoid" id="A0A167PIN3"/>
    <dbReference type="OrthoDB" id="264392at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025969">
        <property type="entry name" value="ABA_GPCR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022535">
        <property type="entry name" value="Golgi_pH-regulator_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015672">
        <property type="entry name" value="GPHR/GTG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 89-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948:SF0">
        <property type="entry name" value="GOLGI PH REGULATOR A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12430">
        <property type="entry name" value="ABA_GPCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12537">
        <property type="entry name" value="GPHR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Golgi pH regulator conserved" evidence="9">
        <location>
            <begin position="154"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Abscisic acid G-protein coupled receptor-like" evidence="8">
        <location>
            <begin position="284"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="244"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD78016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="56048" checksum="EC1411342D5AABCF" modified="2016-07-06" version="1">MSLIDGIIILLIQLILLTLGTNLATRLLFKGYVPPSTFTQFTNNLIGPHIIFAISLSCSCTLFLLVFAEISNVFSKTTRWHYWQWNLNVLLILVILVIPWYQVYTFLRHSRGWRTKSAAYTTTFVWIIYMYLFEHIGHISQGDTSGYTWLEIGIFRVSIIGITLIAALSGFGVVNTPYTTWAAYTKQVSERDYSIAEHAYEQTKKMIQERSVQLKKLQSQSEEQQPETKASSSKMSQWISSLMNRTNTRELDQLEIEISQMEGLATSMKANLEELARARVKSQFSQTWKGQCWNLVGSVFTVYCVYRLIVTSFNVITRRVGSNDPITNMISLMISHFDKEGSKLDISFWSQQLSFWFAGIIVFGSVRGFLQILTRIMRSWSNKMSISTSTLLLCVAHMMGLYFLSSVLMMQTSLPYDYRYLVSSSLGHIEFDYFRRWSDIIFMIASLLTGLVLFVINQTSDVQSLAADFADMNFLSAESGLNSIPDSRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PTB0</accession>
    <name>A0A167PTB0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_163609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296539.1">
        <property type="nucleotide sequence ID" value="XM_018434841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PTB0"/>
    <dbReference type="STRING" id="763407.A0A167PTB0"/>
    <dbReference type="GeneID" id="28995747"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_163609"/>
    <dbReference type="InParanoid" id="A0A167PTB0"/>
    <dbReference type="OrthoDB" id="2211878at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="445" mass="51544" checksum="B405E7EE508D66BE" modified="2016-07-06" version="1">MQTGYYSLLLNGTLFLHNSIDSTLLKAPGVVHWDIDNISFYSTCLLIKTILSLKVLIKSSLPYHKYNNKAYMKANKIRNELDKISPQLIFRQMIIRFKSKLDSVKELPLDSGNPIKECGKGVSKAKDRTILNPDKFSYEGTDNVLVNITTSIPMSLPRMVFHLKLFGHYTALSTHSNEDNISLRLSKEEETFLRFSSVTNMKASDVDVSRGCFRQRRYLERLKKHTDGGKEVQSIEDSTRKMASTPVTFSAMVIENLHEQYKQRRKLRDFYNSAKMINQKRHVEIQQHRYCHRLFRRKRLKPKHSDSKFSSKKSLLFFTGDRGTGTIFRPKGFRMYGGKWKQKIHRETANVCITNECKTSQTCIFSFSSLINPRIPGKKEGSYKGNKGTFLCINSRCITVKKQWAMPVHFLRGSKGAHSQAYLLHRFRVFKADRLPSNRLFLRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q3E9</accession>
    <name>A0A167Q3E9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_62225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD79006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297046.1">
        <property type="nucleotide sequence ID" value="XM_018440936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q3E9"/>
    <dbReference type="GeneID" id="29001842"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_62225"/>
    <dbReference type="InParanoid" id="A0A167Q3E9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="329" mass="37661" checksum="8B8B2BCEEE373857" modified="2016-07-06" version="1">MYRLKSRTIKSQRYGRKLKGGKVKSKFALEVVEKRGSSGKGSRGDKRNVIKYEQPMMAPYSQQRAAKIEAAEREELVHGENVKDCKPERHETKHCGPHEAGGRTKTDKAGEGQVWGLWGVQNWSGNCRVGGKTGWTNNVKGCRGQEPSRKDTHQQLYWKAYLAKETDRVQDKRASVETFEEPVKDNRTTEYAVEGALGKHAKTRIYFIGVGNLEIAPCRWKGRVVWLCSSEIGERQRETGGEVDYHVREVVREKVNGSKTPKPPSQIGWQKVPREMGGKEQYCINLLMIERSRWKKDRGTVTTLRTCQSLERMRELSTVARPQIEREQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QPR5</accession>
    <name>A0A167QPR5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubulin-tyrosine ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_99537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298069.1">
        <property type="nucleotide sequence ID" value="XM_018444098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QPR5"/>
    <dbReference type="FunCoup" id="A0A167QPR5">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QPR5"/>
    <dbReference type="GeneID" id="29005003"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_99537"/>
    <dbReference type="InParanoid" id="A0A167QPR5"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027746">
        <property type="entry name" value="TTL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="38898" checksum="98F19448C0360280" modified="2016-07-06" version="1" fragment="single">LQWLEYEQINWLHLSRHSETTMANAYCIRKGLIRKAQLAYNMTKYLSKNPESILKQAIPETWQFELDHVDYFEEAMNEVFEVERDLLENEEKTEDRHMFIIKPSMANKAAGISVFDSMDQLRAIFEEPESDSEDEEYDSDAEDLMQVREWVIQRYIDRPLLVNKRKFHVRAYVLAVSNIQVYLYHDMLALFAHKEYSTTDLSDSLVHLTNTCIQTDEADFDEQSSVRLYWELERLGVPKADLETMFGKMQLILADVFDACVSEMTTFQAIPNAFELFGIDFMMDQDLNVYFLEANAFPDFKQTGAKLQHVIQELFDATTKTAIEPFFSEKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QY31</accession>
    <name>A0A167QY31_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_138012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298491.1">
        <property type="nucleotide sequence ID" value="XM_018429917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QY31"/>
    <dbReference type="GeneID" id="28990823"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138012"/>
    <dbReference type="InParanoid" id="A0A167QY31"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="77" mass="9239" checksum="8CA2178600A4198E" modified="2016-07-06" version="1">MSVPFAQKITGLAFNGFQCVSHATTRIRDKPSRIFFHPGPNPEWFWFHKYTIRYLTGRPILPFNELYYNRHVTFIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R8G6</accession>
    <name>A0A167R8G6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_62155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299137.1">
        <property type="nucleotide sequence ID" value="XM_018440913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R8G6"/>
    <dbReference type="GeneID" id="29001819"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_62155"/>
    <dbReference type="InParanoid" id="A0A167R8G6"/>
    <dbReference type="OrthoDB" id="2210827at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD81097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="248" mass="28373" checksum="9BB4AD470B05ED6A" modified="2016-07-06" version="1">MPPASKKSRLAKSKSQSESGNCFSKNIETSNDDLIDLFEIDVKEDITVDDRELQGITDDVTSAIYSSHFLKWHEGADKSLHDTYQKNSLTAEWRKRKTMKESFDFKGSYLLTEKGFTILSEKESVNEELEPVKVTSRKISANTISLLKLAFNNIKEEIVPFTHIIGSSLPVNHYELCKLKSVENYLRHRLSESKTIEASKKAAMQIQQQKPESRNTILVKKHINEVVIPKKTWNSRTCLDEYSLEISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N1U5</accession>
    <name>A0A162N1U5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ndc10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_118157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285668.1">
        <property type="nucleotide sequence ID" value="XM_018428620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N1U5"/>
    <dbReference type="STRING" id="763407.A0A162N1U5"/>
    <dbReference type="GeneID" id="28989526"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_118157"/>
    <dbReference type="InParanoid" id="A0A162N1U5"/>
    <dbReference type="OrthoDB" id="2287073at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.20">
        <property type="entry name" value="Centromere DNA-binding protein complex CBF3 subunit, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038279">
        <property type="entry name" value="Ndc10_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031872">
        <property type="entry name" value="NDC10_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16787">
        <property type="entry name" value="NDC10_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ndc10" evidence="1">
        <location>
            <begin position="45"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="109" mass="12441" checksum="91B0D884E131C529" modified="2016-07-06" version="1" fragment="single">KTIKYGTAMTYFAAIMDMYQKQVKVGVNNYSHPRKACIQLLDNMKKVEFADLQTVMLDCEEPSKCPAFVLVLKQGKINQFGQIELAACLQNSKVEICPFIALGCYFFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N6S6</accession>
    <name>A0A162N6S6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_152620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441004">
        <property type="protein sequence ID" value="OAD66294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284334.1">
        <property type="nucleotide sequence ID" value="XM_018432963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N6S6"/>
    <dbReference type="STRING" id="763407.A0A162N6S6"/>
    <dbReference type="GeneID" id="28993869"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152620"/>
    <dbReference type="InParanoid" id="A0A162N6S6"/>
    <dbReference type="OrthoDB" id="73348at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1050.10">
        <property type="entry name" value="At2g23090-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045230">
        <property type="entry name" value="MBS1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026939">
        <property type="entry name" value="ZNF706/At2g23090_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21213">
        <property type="entry name" value="GEO09665P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21213:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118359">
        <property type="entry name" value="Expressed protein At2g23090/F21P24.15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD66294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="73" mass="7908" checksum="AC8A7288AC221EB0" modified="2016-07-06" version="1">MARGAQKEQARQKAQKEAAKRAGGVSQLGARAAGLQIKCPKCFSGMANYKLLVQHMEAKHPKDPIPDESTFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N7Y8</accession>
    <name>A0A162N7Y8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_71936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441001">
        <property type="protein sequence ID" value="OAD66634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284674.1">
        <property type="nucleotide sequence ID" value="XM_018442566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N7Y8"/>
    <dbReference type="STRING" id="763407.A0A162N7Y8"/>
    <dbReference type="GeneID" id="29003472"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71936"/>
    <dbReference type="InParanoid" id="A0A162N7Y8"/>
    <dbReference type="OrthoDB" id="2271016at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="40238" checksum="D64015C24D23B02E" modified="2016-07-06" version="1">MRKLSSSGVHMNGFGLPAALRDYLIFIHPILEYGLAIVPASRSDVQILQKAQNMCLQTCIRRPDATMGVVHIAALAALPNLFTRSRALQAKFLHRAETLPSDSLIKALTTQLELSKEKTTWGELRRSVLWKKAQLLKEHQPRLKDPLKEAYVLLCQKEIDMQLASVNRPVTVARGLCKPVWDPVLLLPCTRSERRRLIKWRIAWLPPTPSVECQCGAIKGNQNHMLICPATITLVQKLWSLMDPAPPPEVHLIDYALNCLPRFFKSPGTWCDWWPCLLALLRAVDQTTSSYKLPEEKAHGQIPIDLAAKFRATKPTRPHRIPPPTQEPVPGDPFPHLLSKISTVPRQPPPSVPARNCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N844</accession>
    <name>A0A162N844_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Copper transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_71887</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441001">
        <property type="protein sequence ID" value="OAD66684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284724.1">
        <property type="nucleotide sequence ID" value="XM_018442553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N844"/>
    <dbReference type="GeneID" id="29003459"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71887"/>
    <dbReference type="InParanoid" id="A0A162N844"/>
    <dbReference type="OrthoDB" id="73901at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF27">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD66684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18989" checksum="56542439D0BD2640" modified="2016-07-06" version="1">MASMSGKLWFHSEVQNVHLLFESFTLDSPLHLGLGYLLVVAICWAERAITYWLDGATYKGKKLWPQILLKTTLYGIVMTLRLLYMLICMYFNTGLFITIIFALTSGQLVFEFKKSSKVNLSGGAGYKDRRNDYGYATRPEEETQHLFVPQDEYELAHDMQQTRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NAL4</accession>
    <name>A0A162NAL4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_174412</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285414.1">
        <property type="nucleotide sequence ID" value="XM_018437243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NAL4"/>
    <dbReference type="STRING" id="763407.A0A162NAL4"/>
    <dbReference type="GeneID" id="28998149"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174412"/>
    <dbReference type="InParanoid" id="A0A162NAL4"/>
    <dbReference type="OrthoDB" id="2367755at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD67374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="260" mass="29620" checksum="615C3320C2DA3D05" modified="2016-07-06" version="1">MNFQKILRMMEGRPGHYLVTLRALLSTKKIGKVIGKQGANHRTIETEFNIKLYFHSESDGYGRLTTSVGYPIQTACAWRNILFQIYDESPRFSNRLEIKFLVPLSLSVKLQNPSYSVLSKKQSNQCDLAEIANVSGVDLILQHEALPNTTEQILAFRVEDLDPATLDSFEMAVRMLATCFEHYSHDVYSPVNLYYLPNCAENPPIQSPAYQDFIEKNNIRNEISHSNDDSQLDIQTADSKQYHDPPLVHDETVDSSNFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NB75</accession>
    <name>A0A162NB75_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_24034</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GOT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285584.1">
        <property type="nucleotide sequence ID" value="XM_018439827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NB75"/>
    <dbReference type="STRING" id="763407.A0A162NB75"/>
    <dbReference type="GeneID" id="29000733"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_24034"/>
    <dbReference type="InParanoid" id="A0A162NB75"/>
    <dbReference type="OrthoDB" id="204784at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000137">
        <property type="term" value="C:Golgi cis cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD67544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="118" mass="12863" checksum="A2CABCB0A0CF8783" modified="2016-07-06" version="1" fragment="single">LLEIGVGLTGCGALFMAMGVMLMLDVALMACGNLMIVLGIITTIGPRGAFEYFRRSDRWLGSILFLSGIFLILVKFPLIGFLLELCGCLKLFSNSFPTIFGVLKQLPFIGPKLARIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NBH9</accession>
    <name>A0A162NBH9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_125214</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290858.1">
        <property type="nucleotide sequence ID" value="XM_018429038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NBH9"/>
    <dbReference type="FunCoup" id="A0A162NBH9">
        <property type="interactions" value="606"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NBH9"/>
    <dbReference type="GeneID" id="28989944"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_125214"/>
    <dbReference type="InParanoid" id="A0A162NBH9"/>
    <dbReference type="OrthoDB" id="1688503at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000009">
        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD72818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="132" mass="15007" checksum="4EC4FCD2EFE97F26" modified="2016-07-06" version="1">MKFSADVSSDRSKSRKAHFTAPSSIRRKIMSAPLSKELREKHSARSIPVRKDDEVMVVRGTYKGREGKIVQVYRKKWVIHIDRVTREKVNGATVPIGIHPSKVVVTNLKIDKSRQAILDRKNSASKKNAMEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NCI4</accession>
    <name>A0A162NCI4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_150754</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286124.1">
        <property type="nucleotide sequence ID" value="XM_018432543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NCI4"/>
    <dbReference type="STRING" id="763407.A0A162NCI4"/>
    <dbReference type="GeneID" id="28993449"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150754"/>
    <dbReference type="InParanoid" id="A0A162NCI4"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15047">
        <property type="entry name" value="7tmC_GABA-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF20">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 156-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="536"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="571"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="600"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="651"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="692"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="733"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="758"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="11">
        <location>
            <begin position="534"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="798"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1014"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD68084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1082" mass="120193" checksum="4CE4C7B81477FF59" modified="2016-07-06" version="1">MLISPAFGHSHTTQKPNGKTHSSYLQYDASNNFTFVVTHRNGSTFVSPFVTGNLTELKVGVLLPFHQTDNNSTMQITLSGASAIRMAATEINVRQLIPGAYITLVEKDSYPKEVEGQAAITQAVFSAVSLIQEGVIGLIGDISSSWTSLSALMTSTLQIPQCSFSAVATSLSDKTQYGYFFRTIPTDLLYVDAALSFITSQGWPMIGILYSGDDFGQQLSENIIMKARMRGIIVKTYQSFYEDGPTSNIQQSINALMRSDARVILVAAEGKALTAALTVAANSGYISDSSVWLMFGEATVPLIDSIDRFNRVIAQRIRAPDSIQTVVRYAGLTGLNQKTSQAVDPAEYAARVTTYIRPIDFNTTFSGGVFMFRSRMDLTGYSPFDEFMEKWSRLDPKIYPFGGQTDIISNEGLAYSCMMTMAQGFNHAIHNSTNSTSALTQLALGQLGQYLTPSAFNVSFLGPQGPVLLDQNGDMSVGNFRIYNLQNGSKVEIGNILAGKLNLTLAPIYHDGTTKVPTGVPPRTYINPGYSSPTSIILLVISSFGTLFAVCTILLVLLFRKREVFKASSPLFCVLELVGFILAYISVYFFLGYRTRVDCIVIPVTFHLGYSLVLGNLIAKNYRVYRIFNNIFITRTVVTDLQLLKVSGGILLVDAVLLVSWLCFSDIQAVKIPVSNNSYFVGCSYHGKTHPTFVWILTSFAAGQLIIATFLAIQTRSVGRKYSKYSEYKQIGISVYNIFFSALIGFIIYYMPATDYFTRHYLTATMIVWASTFSLFALFIPKLLKFFSRASVNTQANGKASDLTGRQRPPPSQDCTDFTDKIDGEGQMEHYNGDLLTLDQAANGDTPIDGDLSRSQGRKQRPVLHRQHGPIDALLGSKGIQLDAHEARMPIQHVFRYLPFLAAWDMKNIILFPSHGYFSWISERSNKGRVFGYSHASPNSLSPEAFILKVHGLGLWDVLIQVSDKQTLEQWCDWFNQKNVQKPRSRRCSFITSRTYFTSQAQLTLTATDSSVGRNFLGDGRRESEASMELPPIPHQNHQNHQNHQHPHDSNNLFSGLPILKEHTDERLSHDSLFSFKQEPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NGZ7</accession>
    <name>A0A162NGZ7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_66262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287554.1">
        <property type="nucleotide sequence ID" value="XM_018441617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NGZ7"/>
    <dbReference type="GeneID" id="29002523"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_66262"/>
    <dbReference type="InParanoid" id="A0A162NGZ7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="142" mass="16626" checksum="8061E8B87385DBFE" modified="2016-07-06" version="1">MYRKTIEKNGDRLFSIKVKGQRKVKGKYLEINRGLNIKEKIKVLIAIVLYCTVLHCTALYCTALYFYTRFGCNMSIQLFNQVKLIDTNHFSEICEDINKEYGLLNMNHGVKYFLIVLKSTMVGMSAVQYTTFRPRKESKLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NIK0</accession>
    <name>A0A162NIK0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_167972</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292608.1">
        <property type="nucleotide sequence ID" value="XM_018435768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NIK0"/>
    <dbReference type="STRING" id="763407.A0A162NIK0"/>
    <dbReference type="GeneID" id="28996674"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167972"/>
    <dbReference type="InParanoid" id="A0A162NIK0"/>
    <dbReference type="OrthoDB" id="2262863at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="929"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="935"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD74568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="975" mass="111755" checksum="EE5EA41608E87ACD" modified="2016-07-06" version="1">MQKNTRQETYKIVKTCPPKRQGKLNFSINSGVFTCSECEKEFEKPWLLKRHSKVHHISNQMATNTVLDKSEQAELIVKNTILDANAFDYSSDEDDSSSIRDEEDNIVDEKNDIVNNLFDIEMNSNPVFNAFSDMFSSAAAADEVSMTDDDSEIPEEVFETIGTVNYPTSCYPFRDLQAMILFAFINGDNDMISQQMLKKILLAINLIIKIQQETPIGRTFKFSRLDALLNYQARKKFKMPVFPSQRISVSGSNGNVFAHINLPSNHLRFLMANPKKSKLISSMPNHTPNQLICLEQGEKWRTHHLFQQPMHTVNSIDVWFGNIVYLKTNDCSICFLVELFHTANKNIFARGYLVRAISIVCYGVEVTVTDLRVEQISYVDTIPVERDHYYSISSSLTRLSPAHDFLLFGVHPMKKPMPLSVLPGNVDRDAVFYKVRIVSIILFTDNTSGNCLKQYNPFESWLMRCAALPFKDRNSIANIQFLSTIPKKDGANGMSLLPAIVDDFKKLEKGTMSMFWLLLSSFGLRLTCHVIQNFADCLDQPLHFLAEDATEFRCAKDFVKDFSYFCECHERRTQEHYVLANSSSGRDTEIPNAPKIGMNTPANEISFRDHLTDHLLELQLFDPEKDISVEIFHTILLGVVKYMVIDLVKVVLKNDTVTIARLSEFLTDYTVDNAVKYLIRALFDYNKRTKNELHKAYRTKPKVHYLTHLKEDIIRFGPVLNYETEKGEQFNKHIREHLFHMNCQNTSRDVCLKFAKQVALQHVIDGGLWINSSGNREKSGTGIERFIKDNNESLFYYTFFGSSRELKDNNDTGDIEDDAIQNNSFGAFVFKDDLISRPRMGLVSGSVVKFLSIVSCTDNDRNNNYAKAVMTGEHSDVANMNLICKLDLHIFCNPFYIVPIFTQNDNKNLWWYIETLSIVLETIQTGITARHRKDNHPDTKGQKEEKGGEGFEQRYKTLMQCMIAFPRVKQKAIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NJ17</accession>
    <name>A0A162NJ17_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein Zds1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_76156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288164.1">
        <property type="nucleotide sequence ID" value="XM_018443127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NJ17"/>
    <dbReference type="STRING" id="763407.A0A162NJ17"/>
    <dbReference type="GeneID" id="29004033"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_76156"/>
    <dbReference type="InParanoid" id="A0A162NJ17"/>
    <dbReference type="OrthoDB" id="5589766at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040206">
        <property type="entry name" value="Zds1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013941">
        <property type="entry name" value="ZDS1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089:SF1">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08632">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01327">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein Zds1 C-terminal" evidence="3">
        <location>
            <begin position="454"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="543"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="367"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
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        <location>
            <begin position="517"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="552"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD70124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="592" mass="69189" checksum="ED09E72184AE54B0" modified="2016-07-06" version="1">MSTNTDGPQKQNWFNQNDRSESDAYLSLMLSEYLDNQAVLPIVPESPIVEEPQKLAVAEQVQLTELIWVPANKHPQIAPGEFVNWINTHPTNPARRTSEIKRRNSSLSQSHVSEDEDNLSVKTSRSRSAKSTHSPSTKQKDSQQKTFKDDTMETIQEIEKDANNQLDFMDTMPVVPKESKSLLRRSAFSARGKTRKEALERERKDPRRTMSQRRPSDKEIPPMTDEGISLYDRPVCMSEWVDLGNATFSDDSQLGILSRVHDAETQVFSQLMDESFQEEEEQQQPEKHTIEVEEELSSKIEVEEEQPLPQKLIEKPRPTISEATIKRPTIDRVKSKHEKKPSWLSGLFNDKEKKVRSSTRRVEDEQVSRLLEERRLEERRLENKRLEERRAAEKRLEERRLEEKRLEEKRYSAQATKKQSGLASLFGRSLSIKPKAEPKFVEPKKKKRINQQDIIPPQFINSYRLPLHVERAVYRLSHYKLENPHRPLRHQVLISNFMFWYLSIINQHDNFAQAPQQQYVSNSPHQDDYSSQFHKKGKMSRFIISAKKRKDGPKTLLKDKWEDKSRPPAPQHAQDNHSSDEEDNVPLSYYKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NJP0</accession>
    <name>A0A162NJP0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_167180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292878.1">
        <property type="nucleotide sequence ID" value="XM_018435582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NJP0"/>
    <dbReference type="GeneID" id="28996488"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167180"/>
    <dbReference type="InParanoid" id="A0A162NJP0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="328" mass="37793" checksum="27D5F97C883B5AB8" modified="2016-07-06" version="1">MSDINTTLLNSIQKIEVDLAEIKQALRELQRQFSNQFAPAVSAEDLTTMQQSIIEQSSLERIAESVKRAQLTEYPDQLSKRVINTGGEFKGKNEAQKYNLLLQILHEQDWKARCKEVPQGQPLPPLVPLSGHDLTVKRLHLKTLGRTVKHDIIDKDYPAASKEWKNIPEKNREYYMMHLERLAKNGGLHIHQCKRMWCARSLLRESFKSDNQTHKRRMAEKNKTQRDISDSSLSSPDMSETGDVESPIMADVLSPPPTASVEPARKRSRRSVNAYFTEQVSILYKEIDHSVKAAKEKQEVVLELKAIEQKKECNRGKEGRLIFFFEKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NLH1</accession>
    <name>A0A162NLH1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_110940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293358.1">
        <property type="nucleotide sequence ID" value="XM_018428187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NLH1"/>
    <dbReference type="FunCoup" id="A0A162NLH1">
        <property type="interactions" value="433"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NLH1"/>
    <dbReference type="GeneID" id="28989093"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_110940"/>
    <dbReference type="InParanoid" id="A0A162NLH1"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF76">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="25"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD75318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="333" mass="37523" checksum="CE334C1306CBC752" modified="2016-07-06" version="1">MARLEAKYGRYVKPPQHASNKDSGATSKKNIASGATAVIRLVKNPSTGVILAVKEFKKRGRQEDKRDYRKRMNNEYCISKIASGHVNIVETLDLVLDERERWCTVMEYCAGGDVFNLLAQRTINITTMDRHCLFKQLLTGLEHLHKLGIAHRDIKPENLVLTSRGTLKIADFGVADVVQNDYQTETQLCYKWCGSEPFWSPEVWALCSELSPYDGRALDVWSAAITFFCIRFGRLPFSNAFYNNNGRPIAVPRGAKQGSPAAPNQPDTGHILSEEERTCLAGMLDPNPKTRWTIKQALESTWIEGVEMCHDGDLPNGWRHHHCVPTLNLSHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NLI0</accession>
    <name>A0A162NLI0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Helix-loop-helix DNA-binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_186366</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293368.1">
        <property type="nucleotide sequence ID" value="XM_018439230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NLI0"/>
    <dbReference type="STRING" id="763407.A0A162NLI0"/>
    <dbReference type="GeneID" id="29000136"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_186366"/>
    <dbReference type="InParanoid" id="A0A162NLI0"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11405">
        <property type="entry name" value="bHLHzip_MLXIP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="216"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD75328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="310" mass="34477" checksum="1F5533FF6BFF3ADE" modified="2016-07-06" version="1">MNKLLLSPDYMNDYTVPYTTKLELTDQSSLVYPASSFYVSPLDGASSPCPSSVNAFYDHSMTPFAIQPGSPDSFMSGMSLSMTPPPALSSSVSSSDFASYAQEAPMMVQSSSSSTMASSSSSTTSSSSAYLNETIAKASSLPDSFFPEFLQYSKESYEQSTGGSLRKKRRQQDRLLDDEDKCDELDAPPPKQHIQMTSEDDSGDEMTLHGVSTAEMRRQIHIQSEQKRRAQIKDGFEDLRNELPSCLNKKMSKVALLHRTVQHIQHLKSTQMTILAELERLVHENEQLRTFQQGVLQKQAMESIYSVNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PFB1</accession>
    <name>A0A162PFB1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_153741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441014">
        <property type="protein sequence ID" value="OAD65146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283186.1">
        <property type="nucleotide sequence ID" value="XM_018433239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PFB1"/>
    <dbReference type="STRING" id="763407.A0A162PFB1"/>
    <dbReference type="GeneID" id="28994145"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153741"/>
    <dbReference type="InParanoid" id="A0A162PFB1"/>
    <dbReference type="OrthoDB" id="2285535at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="229" mass="26473" checksum="35C89FD3CB4BC16F" modified="2016-07-06" version="1">MTQTLLQQWNDFKRETPKVCYGIALIGEASQCLAHAFTEVATSYQNEIVEKFANKLICYLWYHIHTMFVSMNPNDVHNIAPLRDILNTRVKLKTLSEFPAKFIPLLTRLLSSIESEHNSHCEYDMMRIPLPQRFIKKSKNRISQYHMTSSTRYSSELNKLKKDNSTNIIESAIPTDKTSGPEKYLQHVAYIRQNLSTLFKFYSAVTEKKPLFLVPRKAKGTRVDGEHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PLP5</accession>
    <name>A0A162PLP5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_171485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288136.1">
        <property type="nucleotide sequence ID" value="XM_018436612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PLP5"/>
    <dbReference type="STRING" id="763407.A0A162PLP5"/>
    <dbReference type="GeneID" id="28997518"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171485"/>
    <dbReference type="InParanoid" id="A0A162PLP5"/>
    <dbReference type="OrthoDB" id="1232at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="414"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD70096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="463" mass="52915" checksum="E2CAD2147AC3B64C" modified="2016-07-06" version="1">MPFDVRRLPVLRLFSILPNPSVNWRSVAISVNALSAVVKNPLPRGYINQLQLFHEVFNFKLLRYSSYYWGPKSTRNTTPKKRDTSKCLHLTALFDNTCKEEFQFTLSEQLLEKNICYPIYRITFRREGHCFCARDILAEFSLIYGHFCQNIPRSVPGHTFVLAYFKYVVNVCLNLKWHNRRNILILLIIKRGRIKTNRRRSGNNNNSINGMSQNNEIYTKCTENEQESDVDLTFAMDTNLTRQYSSPTPVSASTVVLYRQFRQSYIGSHGPTQFGNLPESNDLLAIKANLEELLTSAETRNRLLKRDLNHLEKDVKINDNGGRPVCLMDHQSKKGSSASSGKNMGAILEQMRSKQERSFGENAIDGIHGSMTKEQIVLFNFDASGVKMIMETQLTSMATTSRSASPHHIVKIKKLEGESPLTSRSLSPPSVSKPHSHSKHITNKGSDAKRDRQKNNNDENQWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PPI7</accession>
    <name>A0A162PPI7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_147466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289756.1">
        <property type="nucleotide sequence ID" value="XM_018431870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PPI7"/>
    <dbReference type="GeneID" id="28992776"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_147466"/>
    <dbReference type="InParanoid" id="A0A162PPI7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="212" mass="23528" checksum="56ADF59D6F751666" modified="2016-07-06" version="1">MGTTRINSSSSFKTIGSGLQKGIWDDRVYIMDREHQQEQVEAGSWCGKPGSGSSSAIRWSNPFAVDPIAASWHIVSARSLVVYCRWSRIPPTGDQGPFRPVIKEHFAVPSPSLQMMLPIPRQVPLLTKQILSIKPYSTLSTPIMRPIPKPESCARMTAARTNRGAFLSKSKIWAVPPSLKAKSISKKGSNAKFQKQVPKEKPKTKNQIRGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PQH5</accession>
    <name>A0A162PQH5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit GON7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHYBLDRAFT_144411</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GON7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293097.1">
        <property type="nucleotide sequence ID" value="XM_018431218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PQH5"/>
    <dbReference type="GeneID" id="28992124"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144411"/>
    <dbReference type="InParanoid" id="A0A162PQH5"/>
    <dbReference type="OrthoDB" id="2288868at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014849">
        <property type="entry name" value="EKC/KEOPS_Gon7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08738">
        <property type="entry name" value="Gon7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAD75057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="84" mass="9095" checksum="FC3C8E20E174AA37" modified="2016-07-06" version="1">MSSVTAITTSGTDTKKFEATITQESSDSMAGLTAAIIAVQKDINQYLTQRLAAGNMPATADDVVEDEEEEPEEEEEQNEEKTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PQT3</accession>
    <name>A0A162PQT3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Ubiquitin-related modifier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">URM1</name>
        <name evidence="8" type="ORF">PHYBLDRAFT_147035</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6 7">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the URM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290096.1">
        <property type="nucleotide sequence ID" value="XM_018431786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PQT3"/>
    <dbReference type="FunCoup" id="A0A162PQT3">
        <property type="interactions" value="437"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162PQT3"/>
    <dbReference type="GeneID" id="28992692"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_147035"/>
    <dbReference type="InParanoid" id="A0A162PQT3"/>
    <dbReference type="OrthoDB" id="10248987at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01764">
        <property type="entry name" value="Ubl_Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000021">
        <property type="entry name" value="Ubiquitin-related modifier 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03048">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015221">
        <property type="entry name" value="Urm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14986">
        <property type="entry name" value="RURM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09138">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037379">
        <property type="entry name" value="Ubiquitin-related_modifier_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="modified residue" description="1-thioglycine" evidence="6">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)" evidence="6">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD72056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="105" mass="11964" checksum="4E58C0468FA04510" modified="2016-07-06" version="1">MAELKINVEFSGGMELLFKNIRKHTLAIPAQSKVNPSGPATLQDLIFYLRDNLMTEKKDLFVDKDTVRPGILVLINNVDWELCDELEYQLEDKDEIVFISTLHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PVR3</accession>
    <name>A0A162PVR3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_167953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292586.1">
        <property type="nucleotide sequence ID" value="XM_018435760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PVR3"/>
    <dbReference type="STRING" id="763407.A0A162PVR3"/>
    <dbReference type="GeneID" id="28996666"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167953"/>
    <dbReference type="InParanoid" id="A0A162PVR3"/>
    <dbReference type="OrthoDB" id="2277222at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="133" mass="14787" checksum="3892DB074447434F" modified="2016-07-06" version="1">MHKLSSLGVHMNGFGLSVALRAYLIFIRPILEYGLAIVPASWSDVQILQKAQNMCLRTCIQRPDATIGVVHIAALASLPNLFTHSHALQAKFLHRAETLPSDSLIKALTMQLDLSKEKTTWGELRLGVLWKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PWX6</accession>
    <name>A0A162PWX6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_142265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294797.1">
        <property type="nucleotide sequence ID" value="XM_018430772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PWX6"/>
    <dbReference type="GeneID" id="28991678"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_142265"/>
    <dbReference type="InParanoid" id="A0A162PWX6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="246" mass="28475" checksum="A8D4643EA203C213" modified="2016-07-06" version="1">MSNSNSKISLSTEDNHAIKNEYKTWYKHDGSKYGLTSMERLQQFMLMNGRENLNMYLGGDKEGRTFKSSKVTILNKCNQYFQEQGVYQTTIQIKSRLNNLLTKQYREAYRVWKNSIKNNSNDEGSISEKEGLKSELNQIYPAFFQMEKDSEQSNGDDDNTDEESAENSHSSNNAEYDSQNDNMSVLCSSPPKSSSSRKHRRVDVKYKELAKEITRQLNESSVSLEAKIKRLYREKLEVLKGDLHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PYC8</accession>
    <name>A0A162PYC8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_143627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293416.1">
        <property type="nucleotide sequence ID" value="XM_018431031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PYC8"/>
    <dbReference type="GeneID" id="28991937"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143627"/>
    <dbReference type="InParanoid" id="A0A162PYC8"/>
    <dbReference type="OrthoDB" id="2289822at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="238" mass="26339" checksum="7F4A0B1018E9414C" modified="2016-07-06" version="1">MYLEDLYQNDKIEITVFTINQHLLQHYPNMIGAFGPPHAYSTRSVEHAIGKYSCAIKSNSAINMNAGNYENMSAGWPITSKGKCACADSDIEFWGPLVYKTSDDSFEDISCLLILIQDFHRSMGVECGAIEPAIITSCKAFINGCVIDSSFSQKTLREAHHVCLQMQVDLTVLYNGIPVVVNGQLKPKVVHLVDVKELVGLVVSDAMGSTTTTTTTKYIVWPELNRGPKLNIGQYRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T961</accession>
    <name>A0A162T961_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_153725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441030">
        <property type="protein sequence ID" value="OAD65173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283213.1">
        <property type="nucleotide sequence ID" value="XM_018433236.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28994142"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153725"/>
    <dbReference type="InParanoid" id="A0A162T961"/>
    <dbReference type="OrthoDB" id="2253782at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF247">
        <property type="entry name" value="GH16156P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1605" mass="187083" checksum="E96C5AA152C5783D" modified="2016-07-06" version="1">MEDKASCSLVCKAWRKPFQKSMYSDFIVKDNSYLIKWCSKFMDPECTIQKTGHLLRSLHLNYCPYVKSGEIYALQKTFQNIKYLSLEKICLNPSYVGGATNWSLWKTLTDLRINLGGRAPTRADNILLEIVSNLPLLKQLKLTGRYYFHAQPTFTLSDSELIHERLLHLNHLELSSAELTFSKTDLERMTKVLPAKKIKAFGIESKNIDHRWLCYFVRKYPSLESLRLSISNERVEPEEHRNDIICQPRDLPHSFQHLKKLSFGDISYHYKEYLLFLDMFTYCKLPLEQLSICSQEIIDDSNTPQDLHTFIKVMELCSTQFSETLKVFTFEYYDKNPISIDMIIEGKDAFRNLVHLHVHCALVNFKLDVLFDTKVCLEFLHLSFTNICINPSPCSGSKKHVLRSFKVYRATITSDVLRYLSFHCRKMDTLYLHKTKISGPFNSTTGCQYIDMSYTRFKILHIHNTEFIISNNPISKNNHNITLITRPVNDTHPKSYEITEDAQKVIEELAINMHYHWFYILDDIPIKGLSKSQSNAAKRFFDDFKNKKKNAIKTSFDGDRTREPRLSWKMSCAYGAWKTPFQESMHHVLFVEDSQKLRTWCETLIDLENTRQGTGRILRSLHLGHCVHLTSEQLYTIQKTFPNIKHLYLQNLYINTSYVGTGTNWLIWKTLTELRIDFYGILRTKPDKAFIDTVSNLPLLRRLDFGGDPCNLVDQTLALSDFELLHTRLIHLSHLELSTNLLVTSGTEVRRMTEVLPAKKIKIFRMLSKQTDHRWLYYFARKYPNLEKLTFSTFNDKVESDKQKNDIIALLRNLTRPFQHLKTLHLGSVNYPHKEYLLFWDIITCCKVSLECIHVYSCNAANDRIFSRDLRNLPKVLIEICSTKFSETIKDLSFMCDKHMNIPKSLIKQKDVFCNLVHLKIRYPLEPFKLDDLLDKKIFLQSLTLFKVVIDINPDALTSTKRHALRLFEVHYSNLTSDILRYLSTHCGNLNSLHLIKTIVNGSINSTPGCQFIDLTYTRFKSLRLLGTCFILKDNPKSEHNLNIMLVTRPVEDTPPKNLDQIEALPIVIGGLTVKAHYHWLYADGYGFLKTLPKNQHSKAEKFFMQFEKNKEKALKTIFYEDKTRKPKINWKKNYVYGYTKIKCGYIANCDIDAWKAPFQESMYFDLFVDTIQNLEKWCRTLDDPGYTKQDTGRILRSLHLGYCIRLTSEQLYTIQKTFPSIKSLYLQNLYLKPAFVGTKTDWSLWKSLTELRIDFYETHGTEPDNAFINTVSNLPLLRRLDLGGNAFNCVHQTFTMSDFELLHTRLIHLKDLRLSSYSLDLSESDFELMTEVLPAKKITFFSIISNNTDHRWLYYLARKYLNLEMLKFSSGNKNDESEEQRNDIISLLRSLAHPFQHLVGLDVGDPNYPFKEFLLFWELVVFLKIPLRHLGVYACEVLSDRMTSEVLQDLTKVAMKMCSSRFSETINELTFNYPLDPFQLDDLLDEKIFLQSLYFSGANIGTNPKSFSISKRYRLRSVEANGSKLTSYVLRYLSFYCRNFDTVNLRFTKLFGSITSIRGCPPKSEDSPNITLVIRPVSDIPPKEDDMIAKQKMLHEYVAGREGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TFJ3</accession>
    <name>A0A162TFJ3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_175027</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441001">
        <property type="protein sequence ID" value="OAD66733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284773.1">
        <property type="nucleotide sequence ID" value="XM_018437393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TFJ3"/>
    <dbReference type="STRING" id="763407.A0A162TFJ3"/>
    <dbReference type="GeneID" id="28998299"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175027"/>
    <dbReference type="InParanoid" id="A0A162TFJ3"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="12"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="498"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="502"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD66733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="597" mass="66075" checksum="F561B7ABF2D78B59" modified="2016-07-06" version="1">MFIYPITKLYLICSFVSIGSLAYGYNSGALIAVNVLDKRDSGYQNTKVEDNVLLVVPLALSCLGALCSGLVADFIGRKRSFGVAAMLDLIGSLIQLLARKYWEFLLGRLIASFSVGGRYLKSNARLITLHQLGITLGFSVAFWIGYALHKYTFDKAWRISIGLQIVPAVVLLAGLLFIPESPRWLLCHDRKDEGFGILTDLRCAKDEPIKDTVRMEYTRILENVGYDRQCDAQGVGGLWSKGIENNARRTLLGTSIQSASQLSGISALQTYLPQLAGPVLGTKRVSALLFLSIGSTISLIFTILVDRLNRRKILICGGLGMGVCMIVIVIITGLQTEITDKNTDSESLGALLGFNMSSINRKPSIAIVSLIFGFMAIHSASFGTLAWVYPAEIYTQLIRAKAIGITVAANFCVQIFIVEIAPLMFLNILWGTYIIFGCLCFLISILIYYYYPETKGRSLEEIHLIFSGALFNQRAEAHHPSTAAETLFQMAKISIEESESEFESKEKDKPRSISDLESTSESLMPPICGLSRRKTAPAVMLTRFPDSALLRTKNLRRQQNININNNNNSKEESSLSIRSNPIRRTRKISPYLSIDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TG30</accession>
    <name>A0A162TG30_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_68851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286342.1">
        <property type="nucleotide sequence ID" value="XM_018442017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TG30"/>
    <dbReference type="GeneID" id="29002923"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_68851"/>
    <dbReference type="InParanoid" id="A0A162TG30"/>
    <dbReference type="OrthoDB" id="2288577at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="182" mass="20966" checksum="4C771CFBFF5ED03C" modified="2016-07-06" version="1">MDETDYAHLLQHYKTFYDLPDLVSYQYAMLTNSFVDNEITKLKFIDLLGQQYRGKNGSASCGSLVHVMFVGSDGRNTLAYAGQIQYLFTYSFTHPSNSNIHLTRMVHDHRHVFAYIKWFNTSSDRSREDDGLEFCLPTFSPNSRHCIVPVHRIFLEIATARITTSRNVSKMLVIALPKKLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TGZ3</accession>
    <name>A0A162TGZ3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_174769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD67063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285103.1">
        <property type="nucleotide sequence ID" value="XM_018437332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TGZ3"/>
    <dbReference type="STRING" id="763407.A0A162TGZ3"/>
    <dbReference type="GeneID" id="28998238"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174769"/>
    <dbReference type="InParanoid" id="A0A162TGZ3"/>
    <dbReference type="OrthoDB" id="3263820at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="720" mass="82951" checksum="652C29AF6836A015" modified="2016-07-06" version="1">MAPIRKPTVRKECRCSICKSKTLGFDCVSVKTFKRHQEKDNHDITHVQTPHEDTCDTISSAVSEPVNQEEDGFEFEQEDVEMNSELRNLNDTNDILDIRTRNQPFSETDCVFGPEDNVQYTSDTYKEEYEDESDVEMDNDEDSSLESISELNLIHQFIVISVALFVSLYVVDEGAVILIAIINKILQFLFDPFRLPVSVAGLKRLAGFEALTSGVKKYVACSECHAIYDNEAAPLCCTSPNFVAHGVRWSELHRLQYFDIVRCTIIDPMHNLFLGTAKRMLERWVADGLIDDKKLVAMQKAVEKVVLPPDYTSLGTKIAKGFPYMKADEWKSWCLVYSPVVLRDVLPLPEFKNWIEFVNACRYFTKPSVSEEDIEKGHKCLEEFCKGCETLYDLDLLSPNMHLHLHLRQTMIDFGPVYGYWLFSFERYNSVLKNIKTNRRNGFESTFMRQFIEESWKGDFVRRLLKPMHALACFEIFDKFTTNNNNTNTNTNTNTNTNTYLSHSFSISEYLEASQNLSMIIRGNEPLPPSALPLKTRPLSFMPKHEYDCLVGYYQAAYKNPQISGCKDVIDDSPFVNDWIEMVKSVDLLGQSYKGCIGTNGRGSYIQAYFTERTGSEHAYVGEIQYLFVHNFRPTVSSLTYRNPHSSQHVFAFVKWFKSTLDKTRELEGVELLQDEFYKQDFQSILPVHRILLTVAIVDYKTTKNVNKKLAIPLPKKIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TPY8</accession>
    <name>A0A162TPY8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_60041</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288182.1">
        <property type="nucleotide sequence ID" value="XM_018440592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TPY8"/>
    <dbReference type="STRING" id="763407.A0A162TPY8"/>
    <dbReference type="GeneID" id="29001498"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_60041"/>
    <dbReference type="InParanoid" id="A0A162TPY8"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="66"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD70142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="195" mass="22137" checksum="FBE6275308436BFB" modified="2016-07-06" version="1">MSPQKRSRNPNPKKFPCSGYGDCTMVFTRAEHLVRHVRKHTNEKPFECVVETCDKTFSRFDNMLQHAQTHRREMREEEENQSIGGAGGVRGARSTRAQSRRKRSLQTSPEPCEPPKTSVQNRTQSDACIDHEHLTTGLPSPMSQTSRQEPSPTGRRLSLIDICNPVNVDVYSPHTPSATTMDGHYLFPDVNAFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TZ17</accession>
    <name>A0A162TZ17_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Globin-sensor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_159252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290182.1">
        <property type="nucleotide sequence ID" value="XM_018433951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TZ17"/>
    <dbReference type="GeneID" id="28994857"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159252"/>
    <dbReference type="InParanoid" id="A0A162TZ17"/>
    <dbReference type="OrthoDB" id="10027058at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044398">
        <property type="entry name" value="Globin-sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071:SF1">
        <property type="entry name" value="GLOBIN-SENSOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071">
        <property type="entry name" value="PROTOGLOBIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11563">
        <property type="entry name" value="Protoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Globin-sensor" evidence="2">
        <location>
            <begin position="15"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD72142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="229" mass="26208" checksum="F23705302044517F" modified="2016-07-06" version="1">MQHIDNDQLYQDSTYRFEYVSKFMDFGEADIKAIQDVAELVRPLVPVVVDAVYAKLFEFDVTKRFFLPKNDGFEGELPATLEELTLNHPQVKFRKEFLGKYLYKILSGPYDERFIRYLDWVAKIHTDTPEKKSKINVDYIHINALMGFVETALVGGLLSLNLDRQTEGAALAAFNKLLWIQNDYFAKYYIKPEKKAVVAKSFPVDLTILPFAVGALAGALGVWLGLQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U105</accession>
    <name>A0A162U105_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_159179</name>
        <name evidence="2" type="ORF">PHYBLDRAFT_159187</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">NRRL 1555</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290632.1">
        <property type="nucleotide sequence ID" value="XM_018433933.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290682.1">
        <property type="nucleotide sequence ID" value="XM_018433937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U105"/>
    <dbReference type="GeneID" id="28994839"/>
    <dbReference type="GeneID" id="28994843"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159179"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159187"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="70" mass="7800" checksum="E12F6BA8535B5AE7" modified="2016-07-06" version="1">MAIVESICTKEKLPFHVKSSNDKGALHTRNESQFIGGASFCLQIKGFYTLYTLGIIHGDYNGSKNKIQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UA78</accession>
    <name>A0A162UA78_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_76593</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292762.1">
        <property type="nucleotide sequence ID" value="XM_018443174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UA78"/>
    <dbReference type="FunCoup" id="A0A162UA78">
        <property type="interactions" value="609"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UA78"/>
    <dbReference type="GeneID" id="29004080"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_76593"/>
    <dbReference type="InParanoid" id="A0A162UA78"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="10">
        <location>
            <begin position="193"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD74722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="789" mass="90301" checksum="08E8132AD8201CF5" modified="2016-07-06" version="1">MPSAIYQSPSPSDAPRSVTTEAQRDVENTVLSQNLETLTNIDTIRESLRLLDEEETRIDAALDAMLSKETELLDVLGTLDGLRPQLSTLQSNSSTILETIQRTSVLAEKISDKVRQLDQEQSRAKEAIKYVEDVQELKYCVAGVQEAIRRKDYDEAAGLLQRASRIDKAILEGSLAEFTVPNSENPDHPAKTLADAKASLFKIFSQRFDDAVAQRNEADITRYFKLFPLIHCQTEGLDKYSRFVCNIIKARCAEELRIGETAAPIYFADAMTRLFENIAVLIDQHQPFVEKHYGSGKMLRVLQRLQEEADIQSGNILDRLLQTRKLESKLVEIQSISITKMRLNNVNRSANTLATQSPMMSDTTQSLVDPRQLDISLLELSLISQRSALFHSFIHERATEEMETMADDEKQQDIIMNGKDKRFYGDNGLLLSSGLTKRVKELMNIYLVIDEYLLKGNIEKAMQLDDYDPAVGPTSTCVDDVFFILKKVLKRSITTSEPEVVSATMRVVLKTLDTGYIQVLQRKMATTFSGHESGSRNAEKLLEQAKITYMVVLNNMNVSADYTLRLVEELRTETKAVIWKNTKEDMENVEKALEDLGSITDKFQRLLKGGMEQLMIQILKPRVRPLFQEAYREVKYVLEEEEYNEADSEDMFFKRFRYGFDNLIKLYRNTLTTANFSTLAGLVLDATTLQWERIVSQTRFNQYGALRFDKDLRSVIQYFTSMIEWLSRDRFTRLNQMSTLLNFEEPTEIYEYWGSKAGPVSWRLTVTEVKQILALRLDFDSEEIDGLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UB38</accession>
    <name>A0A162UB38_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_167248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292952.1">
        <property type="nucleotide sequence ID" value="XM_018435611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UB38"/>
    <dbReference type="GeneID" id="28996517"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167248"/>
    <dbReference type="InParanoid" id="A0A162UB38"/>
    <dbReference type="OrthoDB" id="21418at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645:SF1">
        <property type="entry name" value="YALI0F12243P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="257" mass="28689" checksum="600E908EA5CAAE51" modified="2016-07-06" version="1">MNNNTNSILDSYESTDNALIDSFKAAALKVTTLYKDSLVQNRKAYAAGYQQALQDLYGFISSHPSTTVSQQGDPYTGHPVERGFLPVQDLLEFARERNTQLTSEMGSDDGMAPAQSQSMHITQPATSNPHTQRPSPPEPKTPQTSFGHSNQTQHGSTSGHQYETQAPLTSQATNPFQVDPNTQFTFSLPHNAPTLRASYTPVMHTYDTNHYPETPSDGFKRRYTPSDFSFMGRSINNMNLDAWCEPPHKRGRSRRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UC69</accession>
    <name>A0A162UC69_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_64971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD74023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292063.1">
        <property type="nucleotide sequence ID" value="XM_018441381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UC69"/>
    <dbReference type="GeneID" id="29002287"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64971"/>
    <dbReference type="InParanoid" id="A0A162UC69"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="126" mass="14864" checksum="5BEEB60B95C2C416" modified="2016-07-06" version="1">MSYFRKFAKVVLNKLDFFGGIVSIFDLKETFNSYDFSSKYYKIVEALCVCVDLRRRGGRLQYMDENSTVRRSRYYSFTLKRSNVTSHGIPRCTNKNYSKDMASLQCEYRLSDKDLAVDLKLQHIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UH61</accession>
    <name>A0A162UH61_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_166938</name>
        <name evidence="3" type="ORF">PHYBLDRAFT_167501</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293223.1">
        <property type="nucleotide sequence ID" value="XM_018435652.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293750.1">
        <property type="nucleotide sequence ID" value="XM_018435535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UH61"/>
    <dbReference type="GeneID" id="28996441"/>
    <dbReference type="GeneID" id="28996558"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166938"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167501"/>
    <dbReference type="OrthoDB" id="2596771at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="552"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD75183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD75710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="701" mass="81197" checksum="56DD938FE3EC0F4B" modified="2016-07-06" version="1">MSNNNINNTIYDISTIQQVLINSPLEGIKMLPLNSTILVKASEWEKCLERINVLCSTKWNKKHKYSGKGLVFGETKKCHRAGQYITNRQLRLAQKDTKACSCTAALKIIQHLDNPNVVTFCQTRAHVNHVPGDWDEVRTLPLPSEAIKIIEDQLKSGSSCRSTRISVLRQIDSWGVGVRKPNYEEIYNRMRKMTTLLYMFASDENASISIWLNVKLAEQNYCIFEINLSVYNDGKKQFAFGFQSPMQVSIMRISQSFCLDATHSISSRSDEVLYTLVTRHPQTGKGFPVAYMVTNNQTAIPIKLWLDHLRIKSSFVPMNITIDCSIMEVNAIKEALPHATIHYCDFHVLRAWQHNLDSKIKLNASYTSEQLGNYKTALKNYLRHILIESNEDVFLRAIEDFKLMVQDQPQFLKYFEKKWTENEELLRRWGRPYISQQHQRYVTNNYVESWHNQLKTIYFGRARIRRLDRLIFILTNDVEFYFEQEVERIHFNNGKMGPIDNELARNSFVASKIQNDMLPSMILNPLGETGNSMDDYNGEWQIRSFVTEDKWYTVNISNDLIQSCTCPNFLTRQIPCKHSHLLKRYCGAKFSFIEQREIAGVVLNRQDAVNANENEVEEEVEEELESGGTAEDRGVYVFDEIAAYSATMHHGFEDLQTLKTIPGLDQTKADLIKRALADAVRLMDEYRSENPSYFRNLNTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UIL3</accession>
    <name>A0A162UIL3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_64429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293553.1">
        <property type="nucleotide sequence ID" value="XM_018441294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UIL3"/>
    <dbReference type="GeneID" id="29002200"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64429"/>
    <dbReference type="InParanoid" id="A0A162UIL3"/>
    <dbReference type="OrthoDB" id="3248986at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="453" mass="52674" checksum="4375B0285773B011" modified="2016-07-06" version="1">MPRSKELKSEEINHYLKPLVDEMIQLYLGIQIPTYQQTDGAAVRAALLMVACDIPTARKTSGFTAHNSICACYKCTSSVDFHAFDCDQWRHRSDRANRVHAEKWNSVSIPSERQQLKIEYGVQWSQLYHLRYFDLVHGTIIDPMHNLFLGTPKRMIETWTKIKKMKNNNLLAMQTVAAMMILPSNYTKLKTKIGKGFSHMKAEEWKSWVLVYSSVLLKPVLPSNMFNGWMHYVKACCILVKPSISFIKIDQAHRYLQEFCQSCEDTYEPKVLTCNMYLHLHLHDTIHDFGPVYGYWLFGFERYNGLLKNNKTNRKDGFETTYMTKFTADAYKADYSLKESTMSDIDYPQLLDYYKIAYAMPNLISYHDARLSQYFVNNQITQLKSIDLLGQTYIGNNSSDEGIAICLPEFYADNYHSILPVHYIHLEVATAVDVTDMNKERMLVIPMPKKYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UJ82</accession>
    <name>A0A162UJ82_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_64579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293713.1">
        <property type="nucleotide sequence ID" value="XM_018441317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UJ82"/>
    <dbReference type="GeneID" id="29002223"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64579"/>
    <dbReference type="InParanoid" id="A0A162UJ82"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="175" mass="20173" checksum="1B62DDFB6E5EC2C5" modified="2016-07-06" version="1">MSYCRQIEVDLAEIKQALCELQRQFSNQFASAVSAENLTTMQKSIIEQSSLEHIAGSVKRGQLTEYPDQLGHMVKHDIIHQDYPAAQKEWKNISEKNREYYMMHLERSFLQESFESNNQTYKRRMAEKNKTWQGISDSLLSSPDMSETDDVELPIMADVLSPPPMASVEPARKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UZZ5</accession>
    <name>A0A162UZZ5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_178961</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HTATSF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297132.1">
        <property type="nucleotide sequence ID" value="XM_018438067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UZZ5"/>
    <dbReference type="FunCoup" id="A0A162UZZ5">
        <property type="interactions" value="987"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UZZ5"/>
    <dbReference type="GeneID" id="28998973"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_178961"/>
    <dbReference type="InParanoid" id="A0A162UZZ5"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12283">
        <property type="entry name" value="RRM1_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12284">
        <property type="entry name" value="RRM2_RBM23_RBM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000105">
        <property type="entry name" value="HIV Tat-specific factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029123">
        <property type="entry name" value="RBM39_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006509">
        <property type="entry name" value="RBM39_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01622">
        <property type="entry name" value="SF-CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48036">
        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15519">
        <property type="entry name" value="RBM39linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="130"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="232"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="369"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD79092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="461" mass="52854" checksum="8D95C5C73FC54536" modified="2016-07-06" version="1">MDMDVEAMLDAPFQENKTAPVEPERHHEVVVKDDRHREERRSRRSSRSPSRSHGSRSRHSRRHRSRSREYRRSGSRSTSRDRRRRPSRERRRRSPSPRMPPSRGFDRNQRRRGRARSPSPPLPEEERDRRTVFVTQLAQRLKSRELEDFFTQAGRVRDAKIIFDRHSGRSKGVGYVEFYDEDSVQSALAMSGQKLLGIPVVVQLTEAEKNRLAMQAAKNAQMAAQDQELFYQRLYVGSIHFSLTEDDIRQIFEPFGPLDFVNLHKDPETGKSKGYAFIQYKNAEDSKQALEKMNGFELAGRNLKVGLVTEKTSVMSSSLDDDAGLALNSLSRTELMKKLAARQTDLMEELEPSTPFMPPKPIIPVSASRTVMLNNMFNPSEESEPDWMQDLETDVKDECLHFGQVTHIHVNEDSLGEIFVKFGTVDAAERAVKALNGRWFGGRQITAAFVSEAIYNAKFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V364</accession>
    <name>A0A162V364_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Histidine biosynthesis trifunctional protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="19">Phosphoribosyl-AMP cyclohydrolase</fullName>
                <ecNumber evidence="19">3.5.4.19</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Phosphoribosyl-ATP pyrophosphohydrolase</fullName>
                <ecNumber evidence="19">3.6.1.31</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Histidinol dehydrogenase</fullName>
                <shortName evidence="19">HDH</shortName>
                <ecNumber evidence="19">1.1.1.23</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PHYBLDRAFT_176686</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>L-histidinol + 2 NAD(+) + H2O = L-histidine + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 19">In the C-terminal section; belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="19"/>
    <dbReference type="EC" id="3.6.1.31" evidence="19"/>
    <dbReference type="EC" id="1.1.1.23" evidence="19"/>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297663.1">
        <property type="nucleotide sequence ID" value="XM_018437812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V364"/>
    <dbReference type="FunCoup" id="A0A162V364">
        <property type="interactions" value="531"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162V364"/>
    <dbReference type="GeneID" id="28998718"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176686"/>
    <dbReference type="InParanoid" id="A0A162V364"/>
    <dbReference type="OrthoDB" id="1703565at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11546">
        <property type="entry name" value="NTP-PPase_His4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1080:FF:000002">
        <property type="entry name" value="Histidine biosynthesis bifunctional protein HisIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.810:FF:000002">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000050">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000001">
        <property type="entry name" value="Histidinol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1300:FF:000002">
        <property type="entry name" value="Histidinol dehydrogenase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1080">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1980">
        <property type="entry name" value="Nitrogenase molybdenum iron protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="entry name" value="Phosphoribosyl-AMP cyclohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016298">
        <property type="entry name" value="Histidine_synth_trifunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256:SF2">
        <property type="entry name" value="HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="HISTIDINOL DEHYDROGENASE HDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001257">
        <property type="entry name" value="His_trifunctional"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101386">
        <property type="entry name" value="all-alpha NTP pyrophosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="HisI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16 19" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15 19" id="KW-0520">NAD</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphoribosyl-AMP cyclohydrolase" evidence="21">
        <location>
            <begin position="161"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="321"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR001257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OAD79623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="797" mass="86412" checksum="543B85D6CA48B42D" modified="2016-07-06" version="1">MFLPSLDATDVAQASLKNSLTYLGSVLLKNTTVDSVKELIQQTGSTLFWTHASTVEEAVKLWDVGVWKVVFDISVYANVVQELAGIPEERIAVTSALENPLLDFNAVNLDTLVPASILTTDPSVKNKLNVGEAFLAAATTDRADGLYTTMVVDERNTALGLVYSSQESVKESIRLGQGVYQSRRHGLWHKGLTSGATQTLVRIDYDCDGDALRFIVKQHGAGFCHLNTRTCFGAETGLASLQQTLQSRKNSAPVGSYTARLFNDAKLLKSKIMEEAEELCDATEKDDIAWEAADLIYFALTKCVSAGVSIEDIEKNLDKKARKVTRRPGNAKPKWIEPTVAAPKPAPTPAPKPAPKKDGRIEMVTYSSNDISAEKRAKLLLRPIIDSSEISARVAPIMKDVRERGDAALKDLTAKFDRVNLEHATIKAPFNPKDMELDPLTKAAIDQAYDNIYKFHDAQMDRETLVVETMPGVVCSRFARPIEKVGLYVPGGTAILPSTTLMLGIPAKVAGCSEIVIATPPRADGTVVPEVLYVAHKVGASHVVLAGGAQAVAAMAYGTQTVPKVDKICGPGNQYVTAAKMVAQNDTSCLVSIDMPAGPSEVLVIADRTCKPSYVAADLLSQAEHGVDSQVVLVAVDLEDSILAAIEDAIHEQAIRLPRVDIIRESIPKSYTLRVNTIDEAVRFSNEYAPEHLILHIDNAARLIPDIQHAGSVFVGHYSPESMGDYASGTNHTLPTYGYSRMYSGVNTLTFVKHITSQELTAEGLDRLGDTVMRLAEIEGLDAHRNAVAIRVADIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V6M0</accession>
    <name>A0A162V6M0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_178567</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298423.1">
        <property type="nucleotide sequence ID" value="XM_018438006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V6M0"/>
    <dbReference type="STRING" id="763407.A0A162V6M0"/>
    <dbReference type="GeneID" id="28998912"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_178567"/>
    <dbReference type="InParanoid" id="A0A162V6M0"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF174">
        <property type="entry name" value="GH06923P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="3">
        <location>
            <begin position="27"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="3">
        <location>
            <begin position="159"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="191"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="3">
        <location>
            <begin position="305"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="338"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="546"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="639"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="704"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="561"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="677"/>
            <end position="691"/>
        </location>
    </feature>
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        <location>
            <begin position="706"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OAD80383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="770" mass="84526" checksum="8658F8F99F36499E" modified="2016-07-06" version="1">MASTSYQTSSNSGNSSVPWESLMDSQELQIYADLFRKVDVDNKGILLKDEAMTFFRKSDVPNNILAEIWEAADGDNKGFLTDKEFCIALKLIACAQHGTLTGSPILSTTVAKVALPQFDGVTLKNLSKPNRPTPNAPLSPNMNMGAGGNNSADQLTPEERNKYINMFQANNPIDGVLGGDSVKNILIRSKLSPETLHAIWNLADTRKSGTLNQTEFIIAMHYVSQMMKKSIQSLPATLPVHIYTAAAGRFGPSRQFSAVSPVMRQMSTQNTHSITTRQMTGPSAVFTGDQSHHPTRGDLDVSPEELAKYSVFFENLNTNGTGYVSGVDAVHFFRHSKLPESDLAKIWDLADTNSSGQLSKQEFGLAMHLINKRMAGGQIPTSLPGLQRAPTQVVNVTGQSELSGPQYNGQQRSLLETELSSVKNDVRAERDRAERLASQHSSEAQAVHALQEQLSKEKQSLESWKKKAEESEKLLEQEKKKRQELSKELHLCSQETKHYQQRSESAKKETEQVHSEVQEMQKDSFSNNSVFALSNTPSNELFTNIGEKSTPEHSFSHPGSAASSTIQSPSMNPTQFNKSFDPFSGMKSDKGNTADSPKISLNRIKQEHEAHQKRSSSPNVDISDIEVKFPDLNTMEEKFNMSSPKASPAISEAKIPTNSASPVQKPYKPSLDHPFGPNQSPAPTTAFSPKQSKSVAKYGFDLSAFETPSTPENEGTSSVKDELSSLFGSPQPEAAKKEPTTNFDDIFSVTPSSVPAPPTENKKTFADIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WHB3</accession>
    <name>A0A162WHB3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_151721</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV441025">
        <property type="protein sequence ID" value="OAD67115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018432731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WHB3"/>
    <dbReference type="GeneID" id="28993637"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151721"/>
    <dbReference type="InParanoid" id="A0A162WHB3"/>
    <dbReference type="OrthoDB" id="2276543at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
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        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="178"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD67115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="319" mass="37147" checksum="9163825EFFB132AE" modified="2016-07-06" version="1">MLHTPINILAKSTLDASAAITQHTLKKMIKMLSDSNVIACEEDHDMYKDFAGICKSKLQQEKLMVMKAQDNISKGRYFFKEQNKTKKLVTQKERLNFMLALDESSFLEELQISIVLDELELNGNSLLSDHFARRSEIGMGSIKNITIRFFKVILSLEHKFVYWPTKSEKLAKVSLWKSEQFFGRRSTYYVNSVAVCNHRRIIQYMSTGFFGSSHDMCTLSECELRKFPERFFSDDEYVLADVGYKAMNNIVPIKKKPRNSELSLADQEKEDIVKVNAWIWVCVALNNFLMCQDDNKWSQEAKHQWEDREKAEVECLQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WU25</accession>
    <name>A0A162WU25_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinylglutamate desuccinylase/Aspartoacylase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_187866</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288905.1">
        <property type="nucleotide sequence ID" value="XM_018439430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WU25"/>
    <dbReference type="GeneID" id="29000336"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_187866"/>
    <dbReference type="InParanoid" id="A0A162WU25"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06251">
        <property type="entry name" value="M14_ASTE_ASPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055438">
        <property type="entry name" value="AstE_AspA_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053138">
        <property type="entry name" value="N-alpha-Ac-DABA_deacetylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010282">
        <property type="entry name" value="Uncharacterised_HutD/Ves"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37326">
        <property type="entry name" value="BLL3975 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37326:SF1">
        <property type="entry name" value="BLL3975 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24827">
        <property type="entry name" value="AstE_AspA_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05962">
        <property type="entry name" value="HutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Succinylglutamate desuccinylase/Aspartoacylase catalytic" evidence="6">
        <location>
            <begin position="469"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD70865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="747" mass="80844" checksum="9006717AA91125D7" modified="2016-07-06" version="1">MLNYSESDLPQGSILESDSPEPSLLTVASLSPERDYKIKAWKNGLGTTSEISIYPPKKDFRKDTFFWRLSLHRIEADCNFTLFPGYYCTTVVLPSQNRKAALLLNHQGDEVSTKVKPLFPYSWHGEWASNCKVTDAPVTSLQFMIKRDLGTAQFDVDKIGQPVSNESGETGKKLILGSFALVYVVEGYVRISVDEDQSSDHIHVLSPGQTLYVEHDEESTPVSMTIKASDMAGNVNHHELDATVLTIQISEIKGGGPSSTVSDYFISQRTPTAAIGTSAISGSGSGSLVGTPITPGAAIERSGHIVSGYHNLHPMSPSEPTDTPSRRREPHRKGSLVIADKFSGSGSDLVSSGTVDTLDSSSTATTATMATTATTTATATATATAKKGGVDQLLSPSAQSQQHGARIYSPPTFGLMYDTDTPPPVVRDRLVVDDFPKHSVSTAWIKMIRQGLNEWIRLPVIICRGSEEGPVVGITAAVHGNELNGVPCIHRVVAEIDVQKLHGTVVAVPCVNVTGYLKFSREFADGRDLNRLFPGKEDGFASQVYCYQLMNKIISQFNYLIDLHTASFGRVNSYYVRADMNDAASATMAHLQKPQILLHNSGQDGTLRSAASARGIKAVTWSFMGVMRILDNLDMFALCNTGTSQPDLSIGSPPSTILCSKGFWIYTTTGGVLEVYPAVNTIIRKGDLIARIKNIFGNVVDEYFAPCGGIVIGRSSNPVAMSGDRILHLGVIKKKGENLPKEAKENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162X8Z1</accession>
    <name>A0A162X8Z1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase</fullName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate kinase cytosolic and mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ADK1</name>
        <name evidence="10" type="ORF">PHYBLDRAFT_124985</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <text evidence="6">Predominantly mitochondrial.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate kinase family. AK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291325.1">
        <property type="nucleotide sequence ID" value="XM_018429022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162X8Z1"/>
    <dbReference type="FunCoup" id="A0A162X8Z1">
        <property type="interactions" value="711"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162X8Z1"/>
    <dbReference type="GeneID" id="28989928"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_124985"/>
    <dbReference type="InParanoid" id="A0A162X8Z1"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03168">
        <property type="entry name" value="Adenylate_kinase_AK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028587">
        <property type="entry name" value="AK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="9">
        <location>
            <begin position="166"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="6">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="165"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="48"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="95"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="124"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="175"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD73285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="255" mass="28082" checksum="E0359D4BC9CDACFB" modified="2016-07-06" version="1">MVDNHSAVLEEIKKNIHSLHEKFAALEKKVVEGLPKQQLRMVIMGPPGAGKGTQAPAIKEKFCACHLATGDMLRAAVASKSPLGIEAKKVMDAGGLVSDEIVVGMIEENLDQNAECKNGFILDGFPRTVVQAQKLDDMLEKRKKPLNSVIELVIDDSLLVSRITGRLIHTASGRSYHREFNPPKVDMVDDITGEPLIQRSDDNAETLIKRLDAFHKQTGPVAEYYKKKGIWYGVDAAQSPKAVWASLNAIFDRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XSW7</accession>
    <name>A0A162XSW7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_186250</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294395.1">
        <property type="nucleotide sequence ID" value="XM_018439208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XSW7"/>
    <dbReference type="STRING" id="763407.A0A162XSW7"/>
    <dbReference type="GeneID" id="29000114"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_186250"/>
    <dbReference type="InParanoid" id="A0A162XSW7"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000018">
        <property type="entry name" value="Biotin carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000028">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041265">
        <property type="entry name" value="PCC_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18140">
        <property type="entry name" value="PCC_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="12">
        <location>
            <begin position="54"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="11">
        <location>
            <begin position="173"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="10">
        <location>
            <begin position="644"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD76355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="725" mass="80395" checksum="DF011CB832F8C3A7" modified="2016-07-06" version="1">MYQLLSRNGLASVCPARLNTITFLRSPATYRFNHTHSHTDLTSHIHAHQPYKKTFDTLLVANRGEIACRIIKTARNMGIKTVAVYSDLDANARHVQLADEAFHLGPAASSESYLSIPRMLEAIKNTGAQAVHPGYGFLSENPGFVLALEQQGVTFVGPTAMAIGAMGDKIQSKLLAKASGVNCIPGYDGEVFSVQEATSVAHTIGYPVMVKASAGGGGKGMRIAWNDIELADGFKLAKQEAQSSFGDARLLIEKYIDQPRHIEVQVLGDNFGNVIYLPERECSIQRRNQKVIEESPSAFVDEVTRHKMGAQAVALAKHVNYNSAGTVEFLLDSQKNFYFLEMNTRLQVEHPITEYVTGLDLVEQMLYSAAGHPLAISQKDVQMQGWAVESRVYAEDPINYLPSVGRLLTYQEPTITPHVRCDSGFIEGSEVHVEYDPLLCKLATHAPTRQGAIETMIDALDNYVIRGVTHNIPLLRGVMAHPRFQDGQSITTQFLADEYPGGYSRPPMTEQDQHGLFALSAAVWAKKEYSRWGKKGGPSSWDVWVQVTQDQTNTTTEARLEIKRGPDNAFEITSPLHDTWTLSTRWPLDGLLAHATVQETGHKMVLQYLDRLDSGFRIQYQGSKYNVNVLTERQRQLSKLMKKKEREPTSKVVNSPMPGKIISLAVKEGDEVIEGTELAVVEAMKMQNILRTPRTGTIKKIHVHPGTSVKTGQLLIEFQDAVIDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XVK3</accession>
    <name>A0A162XVK3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DOT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_63078</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ANT/ATPSC lysine N-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294755.1">
        <property type="nucleotide sequence ID" value="XM_018441068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XVK3"/>
    <dbReference type="STRING" id="763407.A0A162XVK3"/>
    <dbReference type="GeneID" id="29001974"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63078"/>
    <dbReference type="InParanoid" id="A0A162XVK3"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905706">
        <property type="term" value="P:regulation of mitochondrial ATP synthesis coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026170">
        <property type="entry name" value="FAM173A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13610">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13610:SF11">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD76715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="23875" checksum="84B46732C1900EBE" modified="2016-07-06" version="1">MVLDKHRGTFLRVYTEADIKCQDTSDTDPFPAYLEGIDTTLAPFCPTSANRVLQALEMANVSRDDRLLDLGSGDGRFCTAAVAVYGAAHAMGIESDPSLIEVSKSLCQQVATANAATATAAGDGGFVGKETQEEENACSKVEFVEGDLLALPVLVRDPRWTVIVLFLLPDHTDKFADLLRYHYDRGARIVSLVFNLNEIQGLSLKVSDEPQGIYVYEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y8N2</accession>
    <name>A0A162Y8N2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_62226</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD79005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297045.1">
        <property type="nucleotide sequence ID" value="XM_018440937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y8N2"/>
    <dbReference type="STRING" id="763407.A0A162Y8N2"/>
    <dbReference type="GeneID" id="29001843"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_62226"/>
    <dbReference type="InParanoid" id="A0A162Y8N2"/>
    <dbReference type="OrthoDB" id="128804at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="9"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD79005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="137" mass="15920" checksum="9754901B56AA9E52" modified="2016-07-06" version="1">MLLNVIGFIDETRQAIAQPSEPKEIKKTFYNGWKHIHAIKFQDIVTHDRITSSILGPYFGAKYDQYVNSVSKTEERLEKYLKSASISEASYALYGVPAYMEAACNKSMFKVRVAAEWEFGEIQKYFKFCKYKYAMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YBI6</accession>
    <name>A0A162YBI6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">VPS37 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_162605</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297585.1">
        <property type="nucleotide sequence ID" value="XM_018434661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YBI6"/>
    <dbReference type="STRING" id="763407.A0A162YBI6"/>
    <dbReference type="GeneID" id="28995567"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162605"/>
    <dbReference type="InParanoid" id="A0A162YBI6"/>
    <dbReference type="OrthoDB" id="10260857at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="9">
        <location>
            <begin position="246"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="100"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD79545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="328" mass="37527" checksum="666E7891E574B8D2" modified="2016-07-06" version="1">MIIRKRQQIGSLYIHNSAVSVAVEGQLYEIPWSSTEDDFFILVLLPPQFPDEPPVITISPPGTRHPLIKEDLISNEGQFQWTPSSNLGVLVKSIRDEFNRQPPVKNKNEPLYAPQIPRPNNNNVNININNNNNNNNSNNSHYSHRPPPAIPTANQSTLPSSSGLTNNEYMAISHTTPEQAHELLTSDYAFDLFFHSLERVQNLKTVQGELRNGNESIAYKNLNRQDGLTLLRSEVEALDAEYKKLKEEFDVKEQQQQEAFSRFSASTVLTRLKSGVYEYDEMSESVAQSFLDGDLNHDVFVKQFREMRKVYHLRASKLERAQKDKLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163A3E6</accession>
    <name>A0A163A3E6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_64131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288831.1">
        <property type="nucleotide sequence ID" value="XM_018441239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163A3E6"/>
    <dbReference type="GeneID" id="29002145"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64131"/>
    <dbReference type="InParanoid" id="A0A163A3E6"/>
    <dbReference type="OrthoDB" id="10484529at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="657" mass="76216" checksum="BA4797820C67AF15" modified="2016-07-06" version="1">MPSLPRLLENDCLFSRQFNPENPLTHLPFGSRLITFAAKEKLKLLLSKQRYSEAFQLLRGLLKIRFYKPKAFWKVCAEIVQHLAPYDLAGFLYAAFISSSASNGMVILETWINCLLNSDRTQEALEELDRLIDIQPYNTNVELWRIYAMLKFTEWKEKADAIKFQSETNSGDENEDEDEDEEEDDEDIEDRKKRLNYPAATRLLSIVSKASEMVPGDTQLRGAQLEANFKNKTNLMRRIYRYAISRRDPGQMSLLLYYWPETEIGSSEWKRVAVSVCNWDPIANVNVALRPLIENLKKCLPGKHVHVDSSHKNQFLVHKYPRTLQNSSDKNQYKSAVRRACFAEVSAWIMSFHLLLDRLAHGSTDKWTLHYTLKIVEFYIIMQKLPRYSERKYITEFLLEDICNRDMETPLVRLIDICKDEPHEIGNPKIAKIAKILEYCAMFRWHYKALRNPEPEEYVPTETSDPFLSPIINEIEGEVWEEMQDDTPEKDKARRRYESSGGRTEEDIIVELQDLFRKKIMKKKTELYTEICLSSEDEYEEDSGELSNEEELDDTSPLVNNTLDIPLEDPTDKDSSESDTGESRSLVPSKRKKSYGEGSENNIKSEPQSDEYHDDDDDNNGGSDSDSDSDVYIDSDYGKNKATPPFVKRNLRPRTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AE98</accession>
    <name>A0A163AE98_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_100883</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290921.1">
        <property type="nucleotide sequence ID" value="XM_018427612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AE98"/>
    <dbReference type="FunCoup" id="A0A163AE98">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163AE98"/>
    <dbReference type="GeneID" id="28988518"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_100883"/>
    <dbReference type="InParanoid" id="A0A163AE98"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13994">
        <property type="entry name" value="STKc_HAL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF137">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD72881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="264" mass="30348" checksum="8929ACFC40C40FE4" modified="2016-07-06" version="1" fragment="single">VGKGAGGSVRLIRRHTDNKTFAVKQFRKRLPAENEKEYVKKVTAEFCIGSTLHHPNVIETLDIIQEGSTFYEIMEFAPNDLFNVVMSGKMTTEEIGCCWRQLLDGFAYLQSMGIAHRDLKLDNMVLDDRGIVKLIDFGCAVVIKYPHEKESRMSKGICGSDPYIAPEQYIQTEYDARLTDLWSIGIIFVCMTIRRFPWRLPRPSQDQSYKNFITPSTQGAARLFKMLPKESRSIIQRILEPNPRERCTLEQVMEDPWVKSLAMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ARF6</accession>
    <name>A0A163ARF6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_166530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293311.1">
        <property type="nucleotide sequence ID" value="XM_018435430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ARF6"/>
    <dbReference type="STRING" id="763407.A0A163ARF6"/>
    <dbReference type="GeneID" id="28996336"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166530"/>
    <dbReference type="InParanoid" id="A0A163ARF6"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF3">
        <property type="entry name" value="HALOACID DEHALOGENASE, TYPE II (AFU_ORTHOLOGUE AFUA_2G07750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="220" mass="25193" checksum="92D7234107BA9D55" modified="2016-07-06" version="1">MPTIAFNFLGTLFSFDRVIDQLEATFPEDLPSQKQARIFYYAWLWAGIRDYFGTSHAGRYNSLLSILRATLTRARLVQDMEAPTNEEIDQIMAAFDDLLPMATALECFELLRENNWDIWILTNGSYSSTETLLKKHGLDTFVGDNILSCDDLKISKPHPKVYSEFMRSAVHKTKRIENFYLIAAHAWDLAGAKNVSVRTVYLTTEEKVYSADAYDVGFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AUD4</accession>
    <name>A0A163AUD4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_110097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293931.1">
        <property type="nucleotide sequence ID" value="XM_018428151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AUD4"/>
    <dbReference type="STRING" id="763407.A0A163AUD4"/>
    <dbReference type="GeneID" id="28989057"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_110097"/>
    <dbReference type="InParanoid" id="A0A163AUD4"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="18"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="191" mass="22408" checksum="B7F4CCE99FC91D2F" modified="2016-07-06" version="1">MRPIKFYDVTLKGLSRVSWSPNTCKIRYALNLKNIPYETVWISLSQIFSEIPKVTKSADGPTAPIIFDENNDIAVQDSWKIIKYLETTYPNSPKLLHGNEGLHYLFYQYCENELYDPIFRLNCLDIWRRAGSKGVQSAFRRIREEKYNMTLEDVYESWPEHVKEANKALEPIRKTLSEYPYLSGDKGKREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AV37</accession>
    <name>A0A163AV37_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mso1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_165996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294061.1">
        <property type="nucleotide sequence ID" value="XM_018435349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AV37"/>
    <dbReference type="GeneID" id="28996255"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165996"/>
    <dbReference type="InParanoid" id="A0A163AV37"/>
    <dbReference type="OrthoDB" id="2683368at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="52062" checksum="1E12A63B53919FB3" modified="2016-07-06" version="1">MGMQVVDYRVSTLVVLCKDCGNDVGLYPARHKCQDVIRPAMPTLPAKYANLPDSSLQVPRKTPPPLESSTSSYGSSSTSTVGFPPSPKFSSSATSETTTTSKWARFGKSTPTPREEPNEDEEESIYFNKFAANLPDSHSDSPPVTGKKLWGKVRTNEKWKQLNESAEKPKQTGKIWGKIIQATHSIAEASYVDEKGPESDESDWEGESHVSRVLREHYEKKREALPAWLRDERTSTRRMAEPTSPERRHMDVEPVRADRNSVGRRQRLWASTPDSDRVLSKREQELQDLRQAQAAVPTVYEEPPAPRGREDPYSENIYNNPKSSYSGDNYNRQPQSYNRADNYEPKRNQSTSREHPYEDSYQSRSNHQDQRSGRYDNHVEHDRRQQPQQSYRHQEYENSRGTDPSSAPRQRPQQYINDKDFNPSIPSYGRPAQRSQREMQNRPGRYAETAGGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B5C3</accession>
    <name>A0A163B5C3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_107887</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296401.1">
        <property type="nucleotide sequence ID" value="XM_018428019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B5C3"/>
    <dbReference type="STRING" id="763407.A0A163B5C3"/>
    <dbReference type="GeneID" id="28988925"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_107887"/>
    <dbReference type="InParanoid" id="A0A163B5C3"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030832">
        <property type="term" value="P:regulation of actin filament length"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052409">
        <property type="entry name" value="Myosin-III_kinase_activity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256">
        <property type="entry name" value="AGAP011099-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256:SF3">
        <property type="entry name" value="MYOSIN MOTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Myosin motor" evidence="10">
        <location>
            <begin position="7"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="110"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD78361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="217" mass="24329" checksum="858A4AA2067D8548" modified="2016-07-06" version="1" fragment="single">MSVNNLAQLPDDALLEDTNEEVCQLLHDRFKQDKPYTLLGNHRLIVVNPYKPLDLLNDVTLQAYANHGYKDLLAATDGFAAPEPHVYELATRVYFIMRRRGKDQGIVLSGVSGSGKSTTHRHILNELLLLSTHTRREDKVRQQIVSVNTIVDAFTTAATTDTTTASRIGKFQSLQFNERGRIVGSHLAVYLLDKFRVTRAQTAANYHVFHQLLAGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BCE8</accession>
    <name>A0A163BCE8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_61653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298641.1">
        <property type="nucleotide sequence ID" value="XM_018440836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BCE8"/>
    <dbReference type="GeneID" id="29001742"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61653"/>
    <dbReference type="InParanoid" id="A0A163BCE8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="109" mass="12735" checksum="F061DBA99C741277" modified="2016-07-06" version="1">MGEDAKLVGLAKTIYVFNYKSQDIRICLEYPKFMYFSYNQEELLDSDIFFKRQKLCRKCQYKKTVAHGHGESVSEKNCASSLFVVTFPTKFLTFEKVRCSNLIAGEEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DBF0</accession>
    <name>A0A163DBF0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">chitin deacetylase</fullName>
            <ecNumber evidence="20">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">PHYBLDRAFT_89330</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polysaccharide deacetylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="20"/>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288210.1">
        <property type="nucleotide sequence ID" value="XM_018443712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DBF0"/>
    <dbReference type="STRING" id="763407.A0A163DBF0"/>
    <dbReference type="GeneID" id="29004617"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_89330"/>
    <dbReference type="InParanoid" id="A0A163DBF0"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10952">
        <property type="entry name" value="CE4_MrCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.370:FF:000004">
        <property type="entry name" value="Related to Chitin deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF98">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="18" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 23" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007842260" description="chitin deacetylase" evidence="23">
        <location>
            <begin position="22"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="24">
        <location>
            <begin position="159"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="25">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="OAD70170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="400" mass="44035" checksum="2DD57023CCB12B17" modified="2016-07-06" version="1" fragment="single">MQIKAIAVALAITQAATFTNAAASTVADTYWKSFKSPVDPNNVVLPSIPQTTLHDAVKECTYYETPASFNFDPAEWPTTWETATSNGMSKSKEFLDLYNSLDWKSMPDIPVRKLGSNGAPDMSSYDSANDPDCWWSATTCTKPKHENINADIYNCPEPQTWGLTYDDGPNCSHNAFYDFLQEKKLKASMFYSGSNVLNWPLGALRGIKDGHHIADHTWSHQLMTTLTNEEVLAELYFTQKAIKLTTGVTPRIWRPAFGDVDDRVRWIATQLGLTTALWDLDTDDWTADSPETQAVVEATYDKYIKMGTDGTYAKSGNIVLTHEIDGKTMELAMKYLPKIQTAYKHVVDIATCASITNPYFEDTVVFPTFASYVATGANGGQPSSGNSSVTPAKGSSAAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DHZ3</accession>
    <name>A0A163DHZ3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_155819</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289390.1">
        <property type="nucleotide sequence ID" value="XM_018433443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DHZ3"/>
    <dbReference type="FunCoup" id="A0A163DHZ3">
        <property type="interactions" value="342"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163DHZ3"/>
    <dbReference type="GeneID" id="28994349"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_155819"/>
    <dbReference type="InParanoid" id="A0A163DHZ3"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF35">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="14"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD71350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="514" mass="57044" checksum="76E4EC7CD1CDD49E" modified="2016-07-06" version="1">MGFITRLTTNVYAIGGFAAIAGILFGFDIGSNSGIIGTTQYLEYFHSPSDLLQGGINASLSAGCFVGALVSGYPADRFSRKYTLMGASLLFVLGAVIQAASNGVPMLCAGRVLAGLSVGVTSMVVPLYQSEIAPKEIRGRIVSVQQWSITWGIMISFWIQYGCQFIHNTAAFRIPWGVQGIPAVILFCGMWFFPFSPRWLADNNRMDEAIKVLADIHGDGDINHPRVQQEIKEIQAVINFDRNIASHRYSDLLKPGIRYRVFLGVCLQIWQQLTGMNIIMFYVVYLFQQAGIGSSQQATLVSSGISYVVNVVMTVPAILFVDKWGRRPTMIFGALSMSLFLWIVGGILSTGTWTLDAKDKWTVDIGSKPKADAVVACIYLFVASFATSWGPLGWIYPAEIFPIRVRANAVSMSTASNWLFNWLLSFVVPMLMQRLRFGLYMLFAGFNFLMALHVFLAYPETKGFTLEEMDIVFEHNPRKKISRSIIEKESADRFRTLSEGSINEKEKIAVSSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DXH2</accession>
    <name>A0A163DXH2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_77904</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD74030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292070.1">
        <property type="nucleotide sequence ID" value="XM_018443311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DXH2"/>
    <dbReference type="STRING" id="763407.A0A163DXH2"/>
    <dbReference type="GeneID" id="29004216"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_77904"/>
    <dbReference type="InParanoid" id="A0A163DXH2"/>
    <dbReference type="OrthoDB" id="434253at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024624">
        <property type="entry name" value="Pyridox_Oxase_Alr4036_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243">
        <property type="entry name" value="AGL049CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE ALR4036 FAMILY FMN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12766">
        <property type="entry name" value="Pyridox_oxase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding" evidence="2">
        <location>
            <begin position="8"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD74030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="286" mass="32942" checksum="04A700B50614815E" modified="2016-07-06" version="1">MTKNNLSPSWKKLLKAQLTANIKEQGPSAAYLSLSTVRPDNNPANRVVVFRGFAGESYKEETGWESDLLTITCDKRSPKVQEIAANPNVEICWFMGSTKEQFRIRGRMHAFGDGLNPSESLNSHIGRKHHGMPSLDEEKEEDHETDFSDRLSQASKSFLKRIRSLKHHIKPNAPFDWQAERLRQWYGLTDQLRATFTWPAPGTPKEPVEEEEATFRIETLTIEESDDNGWFSHQDADKRALLERGYENFVVLFLEVTEVDHSYLETSVRTIYRKEDDTWNAVEVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163E5T7</accession>
    <name>A0A163E5T7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type zinc finger transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_142354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294890.1">
        <property type="nucleotide sequence ID" value="XM_018430790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163E5T7"/>
    <dbReference type="GeneID" id="28991696"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_142354"/>
    <dbReference type="InParanoid" id="A0A163E5T7"/>
    <dbReference type="OrthoDB" id="3247418at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="44290" checksum="DFC9DB31463D7D3C" modified="2016-07-06" version="1">MAETMVVPMDYVVLKSKIGKGFPYMKADEWKSWVLVYSPILLKAVLPIEMFRNWISFVDACRQLVKPSITFSDIDDGHKFLQEFCTECQRIYTPTILTCNMHLHLHLHETICDFGQVYGYWLFGFEQYNGLLKNVNTNRKDSFEVTYMNSFVQDTFKGDFVHATLTCPSQVPFLPLLAKLTATAQPSTSKNTITFPQHPFRLSAFIQAYSNPSLPVLGNEPLPPSAFPLHIEPPSAMSDVDYPHLLDYYKVAYCMPNLEGYQHPSSPFSFVNNQIIKLKSINLLGQVYKGCKYASGRSSFVQSLFLGSQGNNRLAYTGQIQYLCLHSFTPPVDNTELQTRVVYQNKHVFVFVKWFQIEHDRSRDLESVDICSADFIACNFECILPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163E6C7</accession>
    <name>A0A163E6C7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_109215</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295000.1">
        <property type="nucleotide sequence ID" value="XM_018428099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163E6C7"/>
    <dbReference type="FunCoup" id="A0A163E6C7">
        <property type="interactions" value="420"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163E6C7"/>
    <dbReference type="GeneID" id="28989005"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_109215"/>
    <dbReference type="InParanoid" id="A0A163E6C7"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="1"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD76960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="464" mass="50402" checksum="8FAFB5B9DACAAF24" modified="2016-07-06" version="1">MISLGGTIGTGLFLASGASIANAGPGGALIAYALIGIMVFFMMECLGEMATFLPISGSFNNYAGRFIDPALGFALGWNYWYNWAVTLAVELTAGSMVMAFWAPWVPGYVWSIVFLVLVLSLNLFSVKGYGEAEYWFALIKVLTVIVFIFLGILVDTAVLGDVYYGVEVFRSGGVRGTGILSTFLTAGFSFQGTELIGVAAGESENPQKNVPKAIKQVFWRIVLFYILSIFIIGLIIPFDDPMLLKNDVGDVSVSPFTLVFQRAGIQPAAHLMNAVILTTVLSAGNSGLYASSRTLYDLACENKAPRVFKKVTKAGIPIYCVLLTGLIGMLAFLTSLFGNGVVYNWLLNISGVAGFIAWLGIAASHYRFRQAYVAQGHLVSDLPFKARLFPVGPIFAFLICSFVLVGQGYDAWSADPVDPLDIVACYIGIPIVLIFYFGYKIVMKSKFIPLMEVDLDTGREEILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163E8J9</accession>
    <name>A0A163E8J9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_76342</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295370.1">
        <property type="nucleotide sequence ID" value="XM_018443144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163E8J9"/>
    <dbReference type="STRING" id="763407.A0A163E8J9"/>
    <dbReference type="GeneID" id="29004050"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_76342"/>
    <dbReference type="InParanoid" id="A0A163E8J9"/>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="3">
        <location>
            <begin position="81"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="495"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="599"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD77330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="715" mass="80656" checksum="EA93919842799E2B" modified="2016-07-06" version="1">MSSSLPSIPVSPFIKALLQCASTLAQATKDLSEASARPPTTIKAKGELTQLSQLVQSQRNWIDDWTMQMHSVQGVMPSHWDADIMARQIASIDSQLFDLVVLDQTSLLHIETRQSKWKPVLDFHRYLSHSFSHQLIYFSGNPTESDPETHLVAYLVRVAYLLLNTYRDFSGFAAIVYALQSPAVRRLHSLWKSCPSLSLASIDEYLSVLSPENTYEAYHKMLHNTLVPYYTRDQTTTKRVAVPWVEAHVGRIALNQRQGDRKNVNRQMSITLGILELCQRNTSTQPAAWIEEALNFSGTLISPPPLPPPSKGSSSSYRPFLDNALANIPALDLRFILPENSLVYHWIVSRVYMSDEQLMEESFAAERPVSAPIMIQSAEEILEELGLEEMEVDADVDNQETEEVRREEIFDEEVLEEDEVQYEAQQQEEVIEGDEGLFNDYVPLSVIAEQEEEYEDDVVMVAGGSSVDQTIHAQQFTDSTVGKSLPIVYQENSAPQVIDETQPHTDMGTAATTSVNNDIPKSADTKSETQIAETVKEHQDDDKNKEEEEEEEEWRGYPVSTENDDEESEKWEGYIGSLSNTNLPNTSEDKEDVWTGYREPSDPSSRRESSLSEASAEWKGYCATSEEAKWEAEARLKVEEKDWQGYTLETLPDSDMEGSLCLDSQDQRHMVRQSSDQDHGYTSLQNTQLKTIGKAAARKIQQGPPVNHTIPAFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EF55</accession>
    <name>A0A163EF55_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_69739</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296360.1">
        <property type="nucleotide sequence ID" value="XM_018442156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EF55"/>
    <dbReference type="STRING" id="763407.A0A163EF55"/>
    <dbReference type="GeneID" id="29003062"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_69739"/>
    <dbReference type="InParanoid" id="A0A163EF55"/>
    <dbReference type="OrthoDB" id="7464992at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF18">
        <property type="entry name" value="PEPTIDASE M48 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="8">
        <location>
            <begin position="214"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD78320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="494" mass="56185" checksum="6BCD76FB01FDC1E3" modified="2016-07-06" version="1">MSIQLLRSRALLQRHSWLVSRLSAGRSYKIYNHKKLIRQTYHLPSPNSYPINQRSFHSSRSTHTPLIPIPAMVLAVIKTGNLVSFVSLSSKTSLTLLPHTFRRDRGKLVAKLLASVPILGMTLLLLIGLDQAPNTSRLRFIYLSEEEEEEIVDLEIAQLLEAHYGIVAPKDNEYVQWLQTIADNIAAVAEDDIRSPVRPYLGYAQGETNENGESKRNYDVNIICDSSTMNAMCAGSRVLVYDLMIQYMDYDSTKLAVIISHEIAHSIQRHFVEAHGFASLMFMLGDITRGVFWMLTESLGPYINQKINETISTFITMETQTTYNRVLEKEADLVGLKLLAKAGYDPTVALEVWTKMAELEENLEHQTIKPVTGSTGRHGSIGHIPSTHASQYEDLEMDVHLFVESLIRSWFGSSHPPSQERLEYMKEHMEDAQKLYKDALRINGPAKEYIFRNERRDNPFEDSSELHTGLAAIKQWAYSVFSWSIIPFHLISKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JBK6</accession>
    <name>A0A167JBK6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_70721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441009">
        <property type="protein sequence ID" value="OAD65657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283697.1">
        <property type="nucleotide sequence ID" value="XM_018442323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JBK6"/>
    <dbReference type="STRING" id="763407.A0A167JBK6"/>
    <dbReference type="GeneID" id="29003229"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70721"/>
    <dbReference type="InParanoid" id="A0A167JBK6"/>
    <dbReference type="OrthoDB" id="5570013at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD65657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="542" mass="58569" checksum="A0BEC5FCEFEEE705" modified="2016-07-06" version="1">MANYDNPKAYYNQSGIYCQNLQSPSLILRPLDYVPAPPMTGSSNSTSNSRPPINNSYSSPARMLKPNGSSGDLPPPPYSPSSPQPSAPPMPGYPSYGTTQPGLLSPALPFPVPQPETPPSTQQQMPIPHPISSPSPNPHIPRDWPTYRTPPPPPPPAWPERRRRSGSCCQSWCKYLFLSILIWLLVLKYIGVYQSPSNIPATLCDDNSADYWEQLPPSFLITQNVKVVVEGRVTGGTIRVNRLPTNAQGTIKPTVRVSANHRNLLKEMSFRYTPGPETLLELIMPTLLPADGCVYVDMVIDLADDAIALDINVTNLSIVVVDPFVINRVNLRTTNAKITFDAPWEGNSLSLQSSNAALSVSGLEASNNINIVTTNGNVLLTTAVAGSAINVRSTNGQIIGSSLTAPLVQLKSTNGRISPGIVVGQNVVVESSNGALLLEVTANKINTHTTNDKINLTVNDVEGSIVRAVTSNSQARLIMNGFKGQFKIKTSHRNSARIKNDSDYPISYTYTSSFSKEGVISSGTGTIYVATSNSDDEITFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JC09</accession>
    <name>A0A167JC09_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fimbrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_42299</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441008">
        <property type="protein sequence ID" value="OAD65678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283718.1">
        <property type="nucleotide sequence ID" value="XM_018440177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JC09"/>
    <dbReference type="FunCoup" id="A0A167JC09">
        <property type="interactions" value="155"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167JC09"/>
    <dbReference type="GeneID" id="29001083"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_42299"/>
    <dbReference type="InParanoid" id="A0A167JC09"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110009">
        <property type="term" value="P:formin-nucleated actin cable organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21294">
        <property type="entry name" value="CH_FIMB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21300">
        <property type="entry name" value="CH_FIMB_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000042">
        <property type="entry name" value="Fimbrin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000010">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000016">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000027">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="118"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="263"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="387"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="506"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD65678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="618" mass="69837" checksum="1D52DE6A065C46D6" modified="2016-07-06" version="1">MPIINAFTLQKKYPQLGVNDINSLIDQFEACDLDGDGYLDQGEIQQVCKSTGYSDSYDEIRATLKQVSTSATSKIDVEEFIDLAARLKAGSNKGAFDVHQHKIKVHGTNSNATHTINEDERTEFTRHINSVMAGDRHIGHRLPIPTNTMQLFDECRDGLIMCKLINDAVPDTIDERVLNVSKKMNNFQMVENNNIVINSAKAIGCSVVNIGPTDIIEAREHLILGLIWQIIKRGLLSKIDIKLHPELYRLLEEDETLDEFLRLPPDQILLRWFNYHLKAAGWERRVKNFTKDVSDGENYTILLNQLKPEICSRAPLQERDVLRRAEQVLENADKIGCRKYLTASAMVAGNPKLNLAFVAHLFNTHPGLDPLSEEEAPEIEPFDAEGEREARMFTLWLNSLNVEPGVYNLFEDLKDGVVLLQAFDKVVPGIVNWRMVSRKEPISRFKQIENCNYAVMLGQERRFSLVGIQGADIVDGQRTLTLGLVWQMMRENIVHTLNSLTKGGRPVSDQDMVRWANEVVQRGGKQTKMTSFKDRSLRTGLFFLDVLNGIKPGIVDYSMVTRGQTDDDAFNNAKLAISIARKLGATIFLVPEDIVEVRAKMNLTFVGSLMLLDRQSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JF51</accession>
    <name>A0A167JF51_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_175830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441027">
        <property type="protein sequence ID" value="OAD65869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283909.1">
        <property type="nucleotide sequence ID" value="XM_018437586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JF51"/>
    <dbReference type="STRING" id="763407.A0A167JF51"/>
    <dbReference type="GeneID" id="28998492"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175830"/>
    <dbReference type="InParanoid" id="A0A167JF51"/>
    <dbReference type="OrthoDB" id="6222486at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013924">
        <property type="entry name" value="RNase_H2_suC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47204">
        <property type="entry name" value="OS02G0168900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47204:SF1">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08615">
        <property type="entry name" value="RNase_H2_suC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="149" mass="16902" checksum="CB38C8B6ABB18082" modified="2016-07-06" version="1">MTSEESLLQTPKAHLLPFGVGVEGSVNANHYLSLDPVVDPLIKATNEKIRTYTTVIHGRRLYGHEIPLNETIKAHLWAQEESMDHPIYDDEDEDEDSEKQSRKFSKVGNSLESFVLWKKDRAPDEKDARLVALESWFAIAQVIHAPVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JQZ7</accession>
    <name>A0A167JQZ7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Geranylgeranyl pyrophosphate synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CarG2</name>
        <name evidence="4" type="ORF">PHYBLDRAFT_183831</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441002">
        <property type="protein sequence ID" value="OAD66529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284569.1">
        <property type="nucleotide sequence ID" value="XM_018438842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JQZ7"/>
    <dbReference type="STRING" id="763407.A0A167JQZ7"/>
    <dbReference type="GeneID" id="28999748"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_183831"/>
    <dbReference type="InParanoid" id="A0A167JQZ7"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD66529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="322" mass="36728" checksum="6B34FB35D40F831A" modified="2016-07-06" version="1">MLTVQFDSKNTFVEPHSNVAFADLPVKSSTKKNQEEILLEPFTYLCNNPGKDVRAKMIEAFDYWINVPKESLNVITRVIEMLHSASLLIDDVEDGSILRRGVPAAHHLYGIPQTINCANYVYFLALSELNKLNNPKMVIIYTEELVNLHRGQGMELFWRDTLTCPSEEEFIEMVDNKTGGLLRLAVKLMQEASNSERDYTGLVGKIGIHFQVRDDYMNLQSKTYADNKGFCEDLTEGKFSFPIIHSIHADPNNRQLINILKQKSSSIELKQFALQLLEKTDTFNYCRKFLTNIEKEAADEIAELGGNPKLEKIMSLLSIKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K8C4</accession>
    <name>A0A167K8C4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_174166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285509.1">
        <property type="nucleotide sequence ID" value="XM_018437201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K8C4"/>
    <dbReference type="GeneID" id="28998107"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174166"/>
    <dbReference type="InParanoid" id="A0A167K8C4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007889236" evidence="1">
        <location>
            <begin position="26"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="238" mass="26928" checksum="611799BA29F11B06" modified="2016-07-06" version="1">MYRYFNSHILVSVIFLKAILKIAFDQNPHGYTSAKTINSLVYTFYISIQGESIGAPHLVLVLQNLLWGHLTYTTSGGSAQHRDEGRLSIKKRSWRNALKPSASYSESWTPPELSQGPEVWLFETSRQLQTFSNLTKSQGNQSLKAHLYFVNSIYIIPVDKSYMPIQESPSVLHILFLCFKICLRSWGHLTYTTSGGSAQHRDEGRLSIKKRSWLNALKPSASYSESWTPPELSQGPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KAJ2</accession>
    <name>A0A167KAJ2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_73297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285647.1">
        <property type="nucleotide sequence ID" value="XM_018442822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KAJ2"/>
    <dbReference type="GeneID" id="29003728"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73297"/>
    <dbReference type="InParanoid" id="A0A167KAJ2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="204" mass="22873" checksum="F427AC4613CEEBA5" modified="2016-07-06" version="1">MITEARTARHLQYEDFTAGWPLTDESECVGAGSDIEFWGPLRNRTIQDSFEGISCLSKLLEDFYKSKGEECSMIEAAIQTSRKAFVNGCIQVDENHDINSAYSPVYKDFFGKVVVFFEHRLNNKRWPLALVEIAAVHLVNGIPVVNNRQMKPKVVHLADVKELVGLVKLDATINTTTTTITITYIVWPELNRGPKLSLGSLADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KEF0</accession>
    <name>A0A167KEF0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_150992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285946.1">
        <property type="nucleotide sequence ID" value="XM_018432587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KEF0"/>
    <dbReference type="GeneID" id="28993493"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150992"/>
    <dbReference type="InParanoid" id="A0A167KEF0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="58" mass="6788" checksum="78C314C5341C4F82" modified="2016-07-06" version="1">MSNTTSSVKYWTRSMEKANIELHRDPKTFKTSVLITELYTTKTRNTCVEFVQPFPNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KJ13</accession>
    <name>A0A167KJ13_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_160267</name>
        <name evidence="1" type="ORF">PHYBLDRAFT_160903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441019">
        <property type="protein sequence ID" value="OAD65094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283134.1">
        <property type="nucleotide sequence ID" value="XM_018434297.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286255.1">
        <property type="nucleotide sequence ID" value="XM_018434153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KJ13"/>
    <dbReference type="GeneID" id="28995059"/>
    <dbReference type="GeneID" id="28995203"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160267"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160903"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="51" mass="5695" checksum="AE59A1EE2B38571F" modified="2016-07-06" version="1">MAPARCPDRIATTRQLDERCAKAQGCNSLSFHTTELKGNQLCEDQDSHSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KJB2</accession>
    <name>A0A167KJB2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_188685</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286275.1">
        <property type="nucleotide sequence ID" value="XM_018439546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KJB2"/>
    <dbReference type="FunCoup" id="A0A167KJB2">
        <property type="interactions" value="235"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167KJB2"/>
    <dbReference type="GeneID" id="29000452"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_188685"/>
    <dbReference type="InParanoid" id="A0A167KJB2"/>
    <dbReference type="OrthoDB" id="10253709at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005371">
        <property type="term" value="F:tricarboxylate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015742">
        <property type="term" value="P:alpha-ketoglutarate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000078">
        <property type="entry name" value="Mitochondrial DNA replication protein YHM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053017">
        <property type="entry name" value="Mito_Cit/Oxoglu_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982">
        <property type="entry name" value="CITRATE/OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982:SF1">
        <property type="entry name" value="CITRATE_OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="20"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="113"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="213"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD68235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="32726" checksum="13A6133298929C6B" modified="2016-07-06" version="1">MAPITSGPVDPSAPLVKKPISWNNLALGAALNLFEVSSLGQPFEVLKTQMAANRSQSILTAIKSVWQRGGVFGFYQGLIPWAWIEGSTKGAVLLFTASESEYYARAAGASPFMAGIFGGMTGGIAQAYSTMGFCTFMKTVEVTRSKAGAQVSTLKIASDIFKKEGFAGINKGVNAVAVRQCTNWASRFGITRYTQDAIIKARYGEGPDAHKKATALDKGLASVAGGALSCWNQPIEVIRIEMQSQVQTPGRPKNLTIVKAFKYIYSEHGARGLFKGVVPRIGLGIWQTVCMVALGDYFKELFGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KLD6</accession>
    <name>A0A167KLD6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type zinc finger transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_173355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286397.1">
        <property type="nucleotide sequence ID" value="XM_018437017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KLD6"/>
    <dbReference type="GeneID" id="28997923"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_173355"/>
    <dbReference type="InParanoid" id="A0A167KLD6"/>
    <dbReference type="OrthoDB" id="3247418at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="43940" checksum="042F4BB6793F9FD8" modified="2016-07-06" version="1">MGVIVQDHLQEQCNMLVCFLQIVATIICCCDLLIQDLSHLKQCSDPGLAECFCNECKNNQEGYSLVQRRTAQRHNKRARYEAFERSEIDISAQSSSMEVDVETFLSQEAGPSEILVSQTNSPFWEANIMSDNNNMTIDNEVIDNADDDNDAENDEEESEEVKKVEEVEDIVEIEVEEFDNEDPFSTPNMPENPVHRFIATFVVMFTSCYVVNKGAVVLIEFINKLLTIYEQDFQLPLSLPGLKRMTGFSTMNKGIQRFLVCQDCHKMYEESALAPFYCDSMKLGARSAHNCQLTKTSSSGLQVAKREYCYESSSTTMSEINKAHNYLQSFCQQCLVIYKPGFLTCNMHLHLYLRETINDFGPVYGYWLFGFERYNGLLKKIDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L082</accession>
    <name>A0A167L082_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_21980</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ORC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287328.1">
        <property type="nucleotide sequence ID" value="XM_018439770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L082"/>
    <dbReference type="STRING" id="763407.A0A167L082"/>
    <dbReference type="GeneID" id="29000676"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_21980"/>
    <dbReference type="InParanoid" id="A0A167L082"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000062">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000199">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="WHD_Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="58"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD69288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="417" mass="46908" checksum="FEC6C7CDD0379221" modified="2016-07-06" version="1" fragment="single">IPITPLKERSIERSTPATSYELARERLHVSAVPDSLPCRENEFEEIMGYLESALEEGTGTCIYISGVPGTGKTATVLEVIRHLQHKSENNEIPPFDFAEINGMKLTDPNQAYNLLWDCLEKSANPGAEQKKRVTSAHALQLLEAKFNQQDSSQKTTVVLMDELDILVTKKQTVMYNFFEWPNRPFSKLIVVAVANTMDLPERMLSNKVSSRLGLTRINFQSYNHSQLFKIVESRLQGIDAFEKEAVEFAARKVSSVSGDARRALDICRRAVEIVESRIRKQTDSDKPASHVTIGIVNEAIREMFSSPSVAFIQSCSLHQKLFLVSVMRRARRTGLADVEFGDTALDHMETCKWYSIDRPTMSDLMRVCESLGQTRALVVEGGRLDLGMRISLNLAEEDIIMTCKSDKVIGRLLDTMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L4W4</accession>
    <name>A0A167L4W4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_149385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287638.1">
        <property type="nucleotide sequence ID" value="XM_018432264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L4W4"/>
    <dbReference type="GeneID" id="28993170"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149385"/>
    <dbReference type="InParanoid" id="A0A167L4W4"/>
    <dbReference type="OrthoDB" id="2286436at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD69598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="192" mass="20564" checksum="9087C51221499DB6" modified="2016-07-06" version="1">MFASKTIVSGEVSSRLLTTIHTDEDEIRTLGVVLSLAGGLMVSFVVVTGLYIYWRCCGGRPYRKPAAVSLTSFLPPSPPPPSLSSIQTPTTNSWTHDPPPLLPPAAISATAGAAGAVHLDMPIPSAPPAKEFNITTTETTGSHQHQHQHSHSHSHSHSHSDSHAYPCPCSTSIIDPWIQDLPPVYTPPTHMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L5T1</accession>
    <name>A0A167L5T1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_172293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287699.1">
        <property type="nucleotide sequence ID" value="XM_018436767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L5T1"/>
    <dbReference type="GeneID" id="28997673"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172293"/>
    <dbReference type="InParanoid" id="A0A167L5T1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="122" mass="13814" checksum="05FBCE1FED41E4ED" modified="2016-07-06" version="1">MPFLPPFELVGFLKRLLYYKIKGASDKKRRRDLLELASKFLLLLKQHSCIIDPLIMLLLQKPFNFKPRYPKSSPTNDSSNSCINNIKSSVGERVVSLIIFSVNQCDCGSTTVQLDCTQCSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LAD3</accession>
    <name>A0A167LAD3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MATE efflux family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_126801</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288017.1">
        <property type="nucleotide sequence ID" value="XM_018429126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LAD3"/>
    <dbReference type="FunCoup" id="A0A167LAD3">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167LAD3"/>
    <dbReference type="GeneID" id="28990032"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_126801"/>
    <dbReference type="InParanoid" id="A0A167LAD3"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD69977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="52453" checksum="79C1417EFF270EE7" modified="2016-07-06" version="1">MSPTENTPLLTSKSPLVSKAYKQEFKWLINNAMPLVLSYLLQNSLQSVSVISAGHLGATELASASLGSMFVTVTGLSVATGGTLALDTLCSQAFTSADDKKIVGLHVQRCLAFLSVLYIPVCVLWWFAESVFLLLRQDPEVARLAGCYVRWMILGAPAFAIFEALKKMLQAQGIFRAPTLVLLMGAPINILLSYVLVWSSTLGLGFSGAPLASCLTYWLIVIFMALYIYRVDGYQVWPAWSTRQAFEWRAWGPMSRLAIPGILLICTETWAYEIIAFGASWIDTTSLGAQSVVLTSITALYTLAFGVGIASANRVGNLLGAQRPQQARIAAHTAIYAAVLVAGLNSLLLLVFRHKWAYMFTSDPDVVSAVAKLLPWVALFVFADNIAGIADGVLNGQGRQHVGAWCNLVAYYVCALPVGFYLCFRSGWGLTGIWAGLVGALIVSCLVTVAVVWTSNWNTEALKAECRTREEVAVKHPEDEESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LEU5</accession>
    <name>A0A167LEU5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_159640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288337.1">
        <property type="nucleotide sequence ID" value="XM_018434028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LEU5"/>
    <dbReference type="GeneID" id="28994934"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159640"/>
    <dbReference type="InParanoid" id="A0A167LEU5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="135" mass="15004" checksum="ADE50168C959E73F" modified="2016-07-06" version="1">MNHHADYAGNAVSPPLGQQQQQQQAYYYPQDGGYVHQEDYGRQDGYGHQDGYARQDGYAHQDGGYYDDSNYYYDGSNVAGGNAGYDMHGQQMPMQNMPVQTSLPTGQQAGIIPPVQPYTGDYYKPDTVDGKPHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LFC5</accession>
    <name>A0A167LFC5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_148874</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288369.1">
        <property type="nucleotide sequence ID" value="XM_018432172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LFC5"/>
    <dbReference type="FunCoup" id="A0A167LFC5">
        <property type="interactions" value="211"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167LFC5"/>
    <dbReference type="GeneID" id="28993078"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148874"/>
    <dbReference type="InParanoid" id="A0A167LFC5"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="79"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD70329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="224" mass="25922" checksum="0220C0F8FC274183" modified="2016-07-06" version="1">MNNAPPITEIVCEWDDCNIPFTSQSALSKHLSEDHFGWRKSEYFCKWTSCPNKGIKIPNRFGLSLHLKTHTGEKMPKSMECSSVDCNQVFSRADALARHRHLDHEDEYMQNTDINIKKHGQFVEGKKRRKTEDIYEGSDESQEEVLTHRTSVESTTIPLAKYKLAKAKLQCILRENELLGDEWTAVKRKLRRLRTERRVLLDALMAGEPEDDQSFIIQDDTSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LLI3</accession>
    <name>A0A167LLI3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_171451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288747.1">
        <property type="nucleotide sequence ID" value="XM_018436604.1"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167LLI3"/>
    <dbReference type="GeneID" id="28997510"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171451"/>
    <dbReference type="InParanoid" id="A0A167LLI3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1991" mass="197432" checksum="5AB8FC33955D3D39" modified="2016-07-06" version="1" fragment="single">IGHHGLLPHGGPITHAVGGVVHGVEHVVEHIPIVGDIAKDINKGAKDVLGKLPGIGGHDSSKIGHHGLLPHGGPITHAVGGVVHGVEHVVEHIPIVGDIAKDINKGAKDVLGKLPGIGGHDSSKIGHHGLLPHGGPITHAVGGVVHGVEHVVEHIPIVGDVAKDINKGAKDVLGKLPGIGGHDSSKIGHHGLLPHGGPITHAVNGVVHGVEHVVEHIPIVGDVAKDINKGAKDVLGKLPGIGGHGSSKIGHHGLLPHGGPITHAVNGVVHGVEHVVEHIPIVGDIAKDVNKGVKAVVDKLPGIGNDDDSKSGHHGLFHHGGPIAHVVHGVEHAFEKIPIVGPIAGGLKNDAKSIVNGLKDGSELVVGKIPIVGDIASDIMKGPESIVGRISGIGGDSSKIGHHGFPPFNGPIVHAVGDVKDTVEHVVGKIPIVGDIAGDIKKGLKATVGKLPGLNGDSSKVGHHGLLGGPIAQVAGKLPGIGGKPSKVGHSGLLAHGGPIGQAVSGAAHKVEDVVEKIPLVGDLQKGARTIIGKLPGIGGDSSKVTHNKMFPHGGPIGNLVGELNKDINHVVEKIPIVGPIAKDLNKGVKSLITPPGIDGNGSGKVSHHGIHHFGLLGHVADALGHVVKDGVEKIPVVGDIAEGLKKGPKAILNKLPGTGGHDSSKIGHHGLLPLGGPIAHAVGGVAHGVEHAVDGVFHGVEHVVEHIPIVGDIAKDINKGAKDVLGKLPGIGGHDSSKIGHHGLLPHGGPITHAVNGVVHGVEHVVEHIPIVGDVAKDINKGAKDVLGKLPGIGGHDSSKIGHHGLLPHGGPITHAVNGVVHGVEHVVEHIPIVGDVAKDINKGAKGVLGKLPGIGGHDSSKIGHHGLLPHGGPITHAVNGVVHGVEHVVEHIPIVGDIAKDINKGAKDVLGKLPGIGGHDSSKIGHHGLLPHGGPITHAVGGVVHGVEHVVEHIPIVGDVAKDINKGAKDVLGKLPGIGGHDSSKIGHHGLLPHGGPITHAVNGVVHGVEHVVEHIPIVGGIAKDLNKGAKDVLGKLPGIGGHDSSKIGHHGLLPHGGPITHAVNGVVHGVEHVIEHIPIVGGIAKDLNKGAKDVLGKIPGIGGDDSSKIGHHGLLPHGGPITHAVGGVAHGLEDAIEKIPIVGDVAKDLNKGIKSVVGKLPGIGGDDSSKIGHHGLLPHGGPITHAVGGVAHGLEDAIEKIPIVGDVAKDLNKGIKSVVGKLPGIGGDDSSKIGHHGLLPHGGPITHAVGGVAHGLEDAIEKIPIVGDVAKDLNKGVKSVVGKLPGIGGDAGSKIGHHGLLPHGGPIAHVVGGVAHGVEHVVEHIPIVGDVAKDLNKGVKSVVGKLPGIGGDAGSKVGHKALPHLGLPHLGLPHLGGPITHVAGGLKDGVDHVIDNIPVVGDLKKGVDSVVSKIPIVGDIVDPKHKHHGLLGALPHLGGDDSSKIGHHGLLPHGGPISHIVGGVAHGLEDAIEKIPIVGDIAKDLNKGAKALVGKLPGIGGDAGSKVGHKALPHLGLPHLGLPHLGGPIGHVAGDVMDGAKSVVDHLPIIGPDSPKLGHHGIFGFPHHGKGIMDIPADAGESAGSAAGGAIEGTKNSAHGVGGLVGDVAGAGAKVADALVGGIPIVGDVTDGLKKGADVIGDGISGLGDAAKHVASGFIDGTDALIGDVPIVGDITGGIKKGADKVAEGLSGLGDGHIGIPGLSGDVPGIGKGIPSFADAAGDVVSGVTGSIKKGIDVVDDGISGVGNIAGDIIKGADALVGDVPIVGDITGSLKKGADLVSGGPLKIGGGLPGLGDVAGDAASTVTGGLKKGADLIGDGISGVGKAASGAASGLAKGVDAVVGKIPVVGDLTGAVKNGAEAIDDKTPSPGSGLPFGIPSIGGVAGGLVKGADSLVGKIPVVGDITGGLSKGVDVVSDHKKSLFPKLGKGHLFGGLAEEETASMMADSDDYLYEASAPAVDLSPVELEYPSFEMGYLSQADLENFDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LSS3</accession>
    <name>A0A167LSS3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_148233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD71018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289058.1">
        <property type="nucleotide sequence ID" value="XM_018432039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LSS3"/>
    <dbReference type="GeneID" id="28992945"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148233"/>
    <dbReference type="InParanoid" id="A0A167LSS3"/>
    <dbReference type="OrthoDB" id="2289822at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="903" mass="102912" checksum="54D702157BFABA79" modified="2016-07-06" version="1">MKAVRYVFSYKLLLAGNSFRNFGNRSPNIRELFTNYRSHCGQIDVFRDVVHVVNVREDKINSAFSAGSSTHISLNDKDLLPLIDDNITEDIPFDPFQPRTYKASCNFEAGDEGHVYGDNIFTENTFTTSQLLSIELYDIVTSFNVPTECHRQLVNLMNTVFRDHDKLSKEYSPEILQAGPVNTLLKKKTAIKAHAYGICENVCKLYNNTQCEEECSHCGSKRFLEPTGDAPAPLVSVKTMKMMSLGDQLARLLGNEEYKALKDQHFFQSPDDIAVALLSDGFVNQKKSKQQLTIVHVMILNYDPSIRYTDEYLIQLAIIPGKPVDLDSFLLPIIDEVISLGKYGLIIKKFDGERIVGKVHMVMASGDIPQVTKYCHHKGHNSRYGCRVCEVLGEASLRGRGMYFKNCSAPLRPKIDFVNGNTNTNIQEPNIFARLPTFTGSSFYGLDEMHLIGHGIGKLVHKLIVLSNTTTSTNNYYPRTADGSLLLKDRYTFSLQKKDVLSAGQCIELSRSKIPVSFQGSWDNLMLKTEGTRAIDYIDLLLYVVPTLLVPLFTKVATQKALLALVRGCSISLQWNLNEELIVEMENHFSIWHQFLQAEITKNNISISVFSPVNHYLTHIGYMTRKVGNLRVYSTRSMERTIGRYLKLIKSRVFCGKNAGNLVERLAIRGYLNCAFNIEQQLDPIKSNQTSLDDYLELPLSSPHSQNHQLWSPFDQLGYLAQFVPIPTFIKELTTYYTRSKCTFPIDLHYTLETVKLVVRAWINNHVYGSEMYKQKRSEVRRGNHYVRINAIYQNHTLWYVGSVLFYFTHNPFDDESCRQFLVLVNVMKEHSVAEYDSNIPVVIMDTNSATQRLVVISLNDIQNQVGLVQSVECPMKYKVVAPYYIFNEDMKSTAGKLRYIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M4N2</accession>
    <name>A0A167M4N2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_170439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289824.1">
        <property type="nucleotide sequence ID" value="XM_018436348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M4N2"/>
    <dbReference type="GeneID" id="28997254"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170439"/>
    <dbReference type="InParanoid" id="A0A167M4N2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="175" mass="19630" checksum="EBCEC3D6514ED164" modified="2016-07-06" version="1">MYNEILSLKAGQENFKLEMKTQMEELKLEITALKNQPETQNTLNQGISPSATIISGGNYIHKPVDNFRDITLRHIFKMISEDLGVEVTSHVKATLTLATKLICDDMAAYPLVIALSSNPSWGSIPAAVKKDMCVSHASIMKDSGIDFTRCLGNRASIERVALLWRDCHRRLQFHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MFS7</accession>
    <name>A0A167MFS7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">T-complex protein 1 subunit zeta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CCT-zeta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_133928</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290774.1">
        <property type="nucleotide sequence ID" value="XM_018429603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MFS7"/>
    <dbReference type="FunCoup" id="A0A167MFS7">
        <property type="interactions" value="594"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167MFS7"/>
    <dbReference type="GeneID" id="28990509"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_133928"/>
    <dbReference type="InParanoid" id="A0A167MFS7"/>
    <dbReference type="OrthoDB" id="10052040at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000038">
        <property type="entry name" value="Chaperonin containing TCP1 subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000058">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02347">
        <property type="entry name" value="chap_CCT_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD72734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="540" mass="59335" checksum="AE869267007D5491" modified="2016-07-06" version="1">MASSALKLINPNSDVARRGQALQLNITAAIGLQEVLRSNLGPRGTIKMLVDGAGSIKLTKDGKVLLTEMQIQHPTAAMIAKAATAQDEITGDGTTSIVLLVGELLKQAERYISEGLHPRVITEGYDAAKNEALKFLETFKTPKPVVDRELLVSVARTSLRTKVHRSLADTLTEAVVDAVLAIYREGEPIDLHMVEIMKMQHRSESESRLVRGLVMDHGARHPDMPKKIEDAFILTLNVSLEYEKSEINSGFFYSTPEQREKLVESERKHVDDKVRKLVEFKNSLCTGVNANKGFVIINQKGIDPLSLDILAKNNILGLRRAKRRNMERLQLVCGGVAQNSVDDLSPEILGYAGLVYEQVLGEEKFTFIEDVKDPYSVTILIKGPNQHTIAQINDAVRDGLRAVKNAIEDKAVVAGAGAFEVALSQHLVEFKKSVKGRAKMGVQAFADALLVIPKVLAQNAGFDAQDVIVALQDEHMEGHIVGVDLKTGETMDPKLEGVWSNYRVHRHMLHSCSVIASNLLLVDEMMRAGRTSLKGPQLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N2L6</accession>
    <name>A0A167N2L6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_167159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292854.1">
        <property type="nucleotide sequence ID" value="XM_018435575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N2L6"/>
    <dbReference type="GeneID" id="28996481"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167159"/>
    <dbReference type="InParanoid" id="A0A167N2L6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="100" mass="11144" checksum="351A11CF0479C171" modified="2016-07-06" version="1">MGLTVEEDSEMAFFGAIQKGAMLDSESDTEELFPGFPVHVLKVAHPSWRSNEFNKFLGLIDESMHSDHKAKGNAKPRMPRFLRGKKNVAVPCRLISSLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N7A3</accession>
    <name>A0A167N7A3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_186324</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293254.1">
        <property type="nucleotide sequence ID" value="XM_018439221.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A167N7A3">
        <property type="interactions" value="721"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167N7A3"/>
    <dbReference type="GeneID" id="29000127"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_186324"/>
    <dbReference type="InParanoid" id="A0A167N7A3"/>
    <dbReference type="OrthoDB" id="16066at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055444">
        <property type="entry name" value="ARM_ECM29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024372">
        <property type="entry name" value="Ecm29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055443">
        <property type="entry name" value="HEAT_ECM29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF19">
        <property type="entry name" value="PROTEASOME ADAPTER AND SCAFFOLD PROTEIN ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23702">
        <property type="entry name" value="ARM_ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23731">
        <property type="entry name" value="ARM_ECM29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13001">
        <property type="entry name" value="ECM29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24492">
        <property type="entry name" value="HEAT_ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome component Ecm29 N-terminal" evidence="5">
        <location>
            <begin position="11"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="ECM29 ARM-like repeats" evidence="6">
        <location>
            <begin position="677"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome adapter and scaffold protein ECM29 HEAT-repeat" evidence="7">
        <location>
            <begin position="1312"/>
            <end position="1466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD75214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1818" mass="202475" checksum="3E1227ED1999BD38" modified="2016-07-06" version="1">MTTSTSELQLLENVELKLALCNTDAKLETTIRIFLPPLLLKLMSTDDRARRKVMEILSHINKRVKSNQSIPLPFDALLAQFVDKSVSTFVKNFTVIYLEMAVQRMSPEDTAKHLPNLLMGISRRPVTQQLTLLHMVLPILRHWKLGDGNQVTARNDIFKFDENPKDVSVILEFFLDILLYQPSSARGQTSADGDSSEISAEPTYPGLSPLALEAITNKGKAEWTSSKLIEARLGIFHFLLTPIFTDSERLRLLLAGVCDSNHQVVSACEDGLRRWASNVNLEDPVFVQSLYTLYLGTKPSAPGAKDARAPVSTSIKIRIIHYLSKSIVATNLVPSMIQVVFDGIYGEKSSLKLRRAAMSFLQWTARMADSAKLGPIAPILISGLLKYIDQDEPLSGHDAEGIKGYAYVACGLIAKKVPKVGLSDTHMLSKFFDNLELEHPNVRVYVQDALSSMIEIYVDIPEDSPIYIPLQDILLDAVEKTNANTRYMALKYANGIYPFSSVFARYICLLGSSSSVAKLEVKEESTRGLHPFVRSSTGFLHTAQDIVPISALPKFVDLVKYMANHRPPPEYSHASKTPCIKGYPVEVYSEMLRFLRMVLILEANPTTILIDQYVEDKVESSMSEDPVTMENFKSLINTWWLGGEMEGKETIEQWLVFVENVLDQNLKDSILLDTAAKCLLEIISLGPSSISTIFKSRLNFFKSFATSEKLEARTLMSHIFGVIASDPGISQSEVEAMLIEFCEILERPETKHHASNLVDQKHGSLLAIGYLLGRCNYRNRELSKEIVQRCVQNIGNNLQGPPNVSFFLLASAACHALSEIGRTRVLPLEDTKTVPATEKSDTTTMEIDPRISTQEIIERLLSLAKSCKDAKVQEKALLALGHLSIPMSKDSSFIPTIVDALFSSAETKQVELFFTGGEAFSVLAFGWESQAMHKYKDISEIPALDSPTLAKASKIESFQEIIEKMVRSYVASDRAWYRKAACIWLLSILKFGKDQAFVQKNLGIIHASFSRLLSDRDDFTQEVASKGLGLVYEYGDAKIKEDMLYSLVGTFTEGRTIQAQSVTDNTVLFEEGALGTTPEGSSITTYKELCSLASELNQPDLIYKFMNLANHNAMWTSRRGAAFGFQNLIAMAEKEMEPYLARLIPKLYRYQFDPNPGVNQSMKAIWNSLVKDNQKTVDVHFNEIMDDLLEGLGNRQWRVREASCAAVTDIVQGRQLAQIQPYLEPLWRMSFRALDDIKGSVRQAATQTCKSLTRLTVHYCDPNVVSVSDGAKVVEIVMPFLLEKGIVSDAEDVQKFSLDAVLKLCKTGAALLKGYIPEIIDTLLQSLSSLEPQTLNYLSFHTEKYNISQEQLDNARLSGAKNSPMMEGIEHCVGQIDEEVMEALSPRIIHIIKKGTGLPTKAGCARFIVTLCMNRRAVFQPFADTFLKALSGAIRTKNPAVRKSFATATGYVYENAHAASAVTIVEMTRFATDRMNAVATEIVPLIYYGEHDPDKNLKALWKDAWENLTSGTRSMVTLYTDEIITFVQPFLSSSSWKVKQTSALTIADLCKSGGNGVSKHASKLMPIMVSTLATRSWAGKENVLEAFVQLCISTPEYFETQEPNLAGVVKILAREAKRNNRVYQRNALLSLKTFLDTFGEKVDALDQVQGFLTDLCQMDETAIMEEDEDTESKPLLLAIKANAFRAIVAAYRPQVFPTQAAQTEDLAKTLTESLEGNVWNVQIAILESLKLFVDQAGAAYLTTPVLQMVLNTGCVYLGNLKYSAIRAAAVDVLESSIATNKVQNDLKTNLQQKLTAYLQKEPVALIQQRIQDLMHKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N9F1</accession>
    <name>A0A167N9F1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_77688</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293444.1">
        <property type="nucleotide sequence ID" value="XM_018443287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N9F1"/>
    <dbReference type="FunCoup" id="A0A167N9F1">
        <property type="interactions" value="352"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167N9F1"/>
    <dbReference type="GeneID" id="29004192"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_77688"/>
    <dbReference type="InParanoid" id="A0A167N9F1"/>
    <dbReference type="OrthoDB" id="346839at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12418">
        <property type="entry name" value="RRM_Aly_REF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF35">
        <property type="entry name" value="RNA ANNEALING PROTEIN YRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="109"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="58"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="189"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD75404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="286" mass="31913" checksum="D722169AB7BF6149" modified="2016-07-06" version="1">MGIQLDRALDEVIKERTYERSGGNRNQDRFSSGGIRKRTAGPGSSRIVQSFVRTVQLRDSPSSNDRTVNQQWKHDLFEDNRSNGYSNNENRSITSRLGGNSAARSVESNEITIENLHYNVTEADLQELFRAVGQVERTRIQFDRSGRSTGTATIRFSNSADTHKAIEKYNNLELDGQAMHIVIAPLRTSRPKVSNGRQNFRSYTTDRGDRNNRGDRNDHGRGGRGGRGGRGGRGDGNRGGRGENSRGARGEGQRKAKSATELDEEMEAYMKTTEKTINEDVDMALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NET7</accession>
    <name>A0A167NET7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_143978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293770.1">
        <property type="nucleotide sequence ID" value="XM_018431119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NET7"/>
    <dbReference type="STRING" id="763407.A0A167NET7"/>
    <dbReference type="GeneID" id="28992025"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143978"/>
    <dbReference type="InParanoid" id="A0A167NET7"/>
    <dbReference type="OrthoDB" id="411871at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="69"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="504" mass="56985" checksum="4E931084A67C6DD3" modified="2016-07-06" version="1">MLFITETWLLSPSHLPTSWSQIHLYGSPVAGTYRGSMGVSVLISPHCPYAVTQIPMPSKYALAVKIGSLRIVCLYLPPNMPTHDVLHVLSSIPLTHDTILCGDFNARLGSVTGDYASNSRGLALCSWIEERFLSVVNADLAPCIPTYIFFRNNYEISSIIDLLITNMPLINPSLHIATDLSLGSDHCLLSLSFAYDLQHSTNMPPPLCKSWNLSRLNEPDVHALYAHIFTQNSTSLLSTLQDIVQNPPLTRPNIDAITDEFNLLIYDSLNSSIGHRPSRPNHWKSFWNVALQTAADHRNQCYKKWRLAIGIDKVVWWTKHKHAQAEFRSQVQQAKRQSWHVFCQSMERDFSKATSKIKQLKRRRQPQHTFQHDDGPAVAAATMCDYLATVYSGHILPATRPPAPMTTCNSVPFASDDSPFTSPIVEEFMQFMPNRKVPGPDHIRAEMLKPVKTHVSPILTLLFTVCWQWSYVPSLCRQAQVFPIFKKHWGIRFLHICDSMGNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NHI8</accession>
    <name>A0A167NHI8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_7078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293950.1">
        <property type="nucleotide sequence ID" value="XM_018442334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NHI8"/>
    <dbReference type="STRING" id="763407.A0A167NHI8"/>
    <dbReference type="GeneID" id="29003240"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_7078"/>
    <dbReference type="InParanoid" id="A0A167NHI8"/>
    <dbReference type="OrthoDB" id="337735at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012389">
        <property type="entry name" value="Cyclin_P/U"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF117">
        <property type="entry name" value="PHO85 CYCLIN PHO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027110">
        <property type="entry name" value="PREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="149" mass="16833" checksum="E60503330E238F25" modified="2016-07-06" version="1" fragment="single">LADMLGRLISHNDLIPLTPSNLTRFHSRTPPNISLSDYLRRIVKYTSAEKSCLLILLIYIDRICESHPHFTISSLTVHRFLITAVTVSSKALCDSYCTNSHYAKVGGLSTQELNALELEFLALIDWHLASSGLILQQYYANLVQQHPCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P1G4</accession>
    <name>A0A167P1G4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Far11/STRP C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_165558</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295108.1">
        <property type="nucleotide sequence ID" value="XM_018435259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P1G4"/>
    <dbReference type="FunCoup" id="A0A167P1G4">
        <property type="interactions" value="488"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167P1G4"/>
    <dbReference type="GeneID" id="28996165"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165558"/>
    <dbReference type="InParanoid" id="A0A167P1G4"/>
    <dbReference type="OrthoDB" id="18234at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040185">
        <property type="entry name" value="Far11/STRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021819">
        <property type="entry name" value="Far11/STRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012486">
        <property type="entry name" value="Far11/STRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239:SF4">
        <property type="entry name" value="AT25231P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239">
        <property type="entry name" value="PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11882">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07923">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01293">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01292">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Far11/STRP N-terminal" evidence="2">
        <location>
            <begin position="34"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Far11/STRP C-terminal" evidence="3">
        <location>
            <begin position="385"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="890"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="890"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="958"/>
            <end position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD77068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="981" mass="112483" checksum="5B755B67F79A57FE" modified="2016-07-06" version="1">MSNEQVSNDQKMQDPLISPDYLKQMAKALSTKTKQVHPYEYHDTEEFYLEIDEFFSYGEVASDLQACRHDSIDSHGPLWKKKDANEREDEVKDLLNQLEYTEQDQRLIALKKLLLISLGDIKGEMTFSLLCKTGAMTVFFQALKRSYASLHTLEYVNKPMSHVFGLNLIKIKSQGKVDQITLENTIKEVNQLQSLLYILIEYCRQKGLFSDGKVKLDSGFIEFLFSEITTLKEKYIRSSLVKKCLFTLVDLKNLSKRGKEQESDMDFLEMVVENPVTKCYPEDFYLFQEDMIEKYSAFSTPEVPDIISNPRSIKTTPELSEAMGISTAINQTDLPYQTLFPPKQNQVSQTENQEGSSEQPIQKQPMPKELTTVVLPVTENGPSFPKSLKDAGEIYLANLHISLADYQMIHEREEAINRWQTLKSLKDGSSNRETVNEPSDETVEDRVETVYRYIVPHLQTIVIVFLKLLLLSINPAKTGERSESLTIEEADMFRDKEITAKSVSATLWLLLKWFKASQLRTQLDVLKYEYFSQLLVDSGSMLLILKILGLQEITSVVATISDVDKYSLLTHLGLPKKDEQTDDVAFTNKRNMFWTINLLRILQILSKRKTARILLLIQYKSSAINMKIVSAIYMRCQPLLRDDWLVTVDSEKELEAADAQEKHLRVLIQLYHGQHYLPEMLPPADDYSNTEGGTFSMTRIRGDREDYNLDAPISMTEVDLAPDFKETCYRWVEEELESTDEIETDNRDAWAIGTPIPSPNEPISPRLLAAEINKLYHEELEQEFKVEAPVVVEDGWDAPALVPPTTTATAAKIKAKYAGNGHDDYENDSDSDEEVQDDDPLGDINWETLTEKDLVDRLTKVEENTSRRWLNIDINDPSYLKVLNTFEGEPLEEPISDDDWDITPDKPLGESTDDGYNNIVDDTWEETSEDSWDRPVRNLQQQSEIDEQDFESGNTWDNTSENSINSSWNNSTSQSNEDNWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P573</accession>
    <name>A0A167P573_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_164183</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295309.1">
        <property type="nucleotide sequence ID" value="XM_018434963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P573"/>
    <dbReference type="STRING" id="763407.A0A167P573"/>
    <dbReference type="GeneID" id="28995869"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164183"/>
    <dbReference type="InParanoid" id="A0A167P573"/>
    <dbReference type="OrthoDB" id="8093034at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF5">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="101"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="208"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD77269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="395" mass="43760" checksum="F669C70F439F4B1D" modified="2016-07-06" version="1">MQNLTTPDEPTLLYIGNLDPRVTELTLAELFSPFGQVKNTKVISDKNLTHSGPRYGFVEYVHPMSAQQALLKMNGSLVFSNEIKVNWGIQRAQKEDNTSQHAVFVGDLSGDVNDDMLAKAFGVFDSITEARIMWDPQSGQSRGFGFVGFRDRAQAEQAIATMNGERLGARAIRVNWANQKNQGPQRLITGPLSANYEKVLNESPVNNTTVYVGNIVPYTQQQDLLPFFQSYGQVTEIRLQPERGFAFLRMESHTSAAAAIVSLQGIVIHGRPAKLSWGRSRPQIRDDNNNNNNRQSIYNQSTPANGWECTYSYSHSYSYRYSHTQPRTVTVTATVTTSGPAPAPASVVVVPATRVPTTTTNLAAVTGSETNKSSGQPNWDPFYPQYYENRASVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P6U0</accession>
    <name>A0A167P6U0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Late embryogenesis abundant protein LEA-2 subgroup domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_108374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295401.1">
        <property type="nucleotide sequence ID" value="XM_018428049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P6U0"/>
    <dbReference type="GeneID" id="28988955"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_108374"/>
    <dbReference type="InParanoid" id="A0A167P6U0"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11006" checksum="07DF0F4DB47D99CA" modified="2016-07-06" version="1" fragment="single">YYPTSPDIPVGGGVVEKLKIDAQGTTNFTFPFHVQYDAAQDSDQRMLMDISSKCGLLGGPKQNIVILYDLTPTIRVLSVPFSFTIRDKVNLPCPIKVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PAG2</accession>
    <name>A0A167PAG2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_157790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295609.1">
        <property type="nucleotide sequence ID" value="XM_018433680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PAG2"/>
    <dbReference type="GeneID" id="28994586"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157790"/>
    <dbReference type="InParanoid" id="A0A167PAG2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD77569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="85" mass="9438" checksum="BEAA8D5CBC34C74B" modified="2016-07-06" version="1">MFPSAKIRPLNHLQRQRITSNLFVVVALGAVLTVAAPTLFPCPAFELNDKAARLEAKRKLKATTSNIPVVIKERRPAVTSEEKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PAN4</accession>
    <name>A0A167PAN4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zn(2)-C6 fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_164484</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295619.1">
        <property type="nucleotide sequence ID" value="XM_018435013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PAN4"/>
    <dbReference type="STRING" id="763407.A0A167PAN4"/>
    <dbReference type="GeneID" id="28995919"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164484"/>
    <dbReference type="InParanoid" id="A0A167PAN4"/>
    <dbReference type="OrthoDB" id="2406834at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="23"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="82"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD77579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="778" mass="87475" checksum="69363BFAC86CCF48" modified="2016-07-06" version="1">MFATLELPLRDENRHKRLKVGRACHPCRMKKIKCDGRQPCMQCKDPSIHLYIIIPNAHSTQTARRRKCIYLKNTDETYIKLDPMTDSTLDSRQSPEATEESHAAVSPPPQQQDNTADTLFASPGSQSPLSNTNPNGDNKPASSRPDKMMEQLTDGLVRLTLHRDTSNFQNEITPWRTYGQFVHWSPDPTLPGQYLASIDMPPRHTQEHLISVFFSNCHHLLPTLSRRMFYDQLSIKGPLITPLLLNIMYAHAAKHVDTIVQAEMFYHRARRLVDDFLDVPRLSTVIALLYMAWFDYDSTQHRPQTRARSSRSWMYCGMAVRMCLELGLHTANYSSQMSQFDIELRKRVLWTCYVMDKFESCTMERPWMLKAVDIAVDLPTPLPEDDSRERTVMEGFGQLCRLTMLLEKILYYFTYDAKNNQTIWTVHQENQTLQFLDALQHWRDSLPPELSWSAPDGIPSLVTANLHLVCLDLELSLLVCCRFQEEQIHRERRRALANSITQLVSYTVQHPHLMYTCALSTFSAVFAALTHATDFNHPMLGVAEEAKDQFRASLGDLRDIVERAPLRDVRGFARLVDLTLQPHLTTSTPTSTSTSTLAPLHPLPRLATLSPSYSAAFSAIHDLCQKHEENQGIDLNLFDHEQQAAAVAAVLDTSTAFSPSSSGVYCPPVSIGSSRQTSPPYSHNHNHNHNHNHNHNHPHTQGHALVAPTFAYNPCLPSNVGHPTSAGAAAAAAAAAAAVGAVGAPVTTSGMSNKEIEPADYTFELISVADEWARSLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PH10</accession>
    <name>A0A167PH10_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">AIM41</name>
        <name evidence="2" type="ORF">PHYBLDRAFT_141762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM41 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295937.1">
        <property type="nucleotide sequence ID" value="XM_018430662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PH10"/>
    <dbReference type="STRING" id="763407.A0A167PH10"/>
    <dbReference type="GeneID" id="28991568"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141762"/>
    <dbReference type="InParanoid" id="A0A167PH10"/>
    <dbReference type="OrthoDB" id="538640at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="entry name" value="Uncharacterised protein YqeY/AIM41 PF09424, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD77897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="184" mass="20401" checksum="D38A7995C7E88407" modified="2016-07-06" version="1">MASLQRSLFLLTSQCRSMPMRSLGLVRHYTSEATESLLDQLKQDRKTLMREKKQPDLNVVKSVLSDYTYYIKSPNAVPGQSENASVLSVLQKGIKRRQDSVAQYAAGGRPELAEQEQAELAVLQRYLPAQMSAEEIESHVRALVAEIGATTARDMGKVMKAWTIDASKADKKTVSDMVKKVLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PHJ5</accession>
    <name>A0A167PHJ5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_74183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295966.1">
        <property type="nucleotide sequence ID" value="XM_018442998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PHJ5"/>
    <dbReference type="GeneID" id="29003904"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_74183"/>
    <dbReference type="InParanoid" id="A0A167PHJ5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD77926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="123" mass="14416" checksum="2AF5702A2EEF2A25" modified="2016-07-06" version="1">MTTVKGTVMVTEKHVAMFYLQSKSCLNIMRKIRFHVVQHTLVSGGWGFLIHIPQYLVCRKGEEALIMINMFFSFTGIQAAAFINDRTCIFRYLYHLHSRILTTYFTVYKTHQIQPLVQLTLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q434</accession>
    <name>A0A167Q434_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_62201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD79034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297074.1">
        <property type="nucleotide sequence ID" value="XM_018440928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q434"/>
    <dbReference type="STRING" id="763407.A0A167Q434"/>
    <dbReference type="GeneID" id="29001834"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_62201"/>
    <dbReference type="InParanoid" id="A0A167Q434"/>
    <dbReference type="OrthoDB" id="2505730at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="213" mass="25050" checksum="95FA35F9AF8B83A4" modified="2016-07-06" version="1">MEKSKLAVLIFHAYAHVQHCLIKLNPKYRDEFGLTDGECLERLWSYLNRFVTMTRKMGQANQKLVLYRAIKFCNETKKVQLGLMLEGKYVKAKRIIEEARKVLEGFDCVVIEREWKQHVNKVEKSENYVDIADLMESGHKVQGNIALFLVNFTILRRLRELTNDANGNHVKDEINRLKHEIEKLKAKIQEEVEGFQEPDEENTNLIKYIEENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q624</accession>
    <name>A0A167Q624_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Secreted aspartyl protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_14411</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297176.1">
        <property type="nucleotide sequence ID" value="XM_018431140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q624"/>
    <dbReference type="FunCoup" id="A0A167Q624">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167Q624"/>
    <dbReference type="GeneID" id="28992046"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_14411"/>
    <dbReference type="InParanoid" id="A0A167Q624"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF1">
        <property type="entry name" value="ASPARTYL PROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007891422" evidence="11">
        <location>
            <begin position="22"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="12">
        <location>
            <begin position="93"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="331"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD79136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="403" mass="42481" checksum="4C890C504088692B" modified="2016-07-06" version="1">MQLTASIFTLLAVATFSSVQAAPAKDIIPPVSTVPVSKTARFTMASNPNFQPNATRSVFKARSKYFKYIEGPVTFSSGVGVVPVVDYANDIEYYGTVKIGTPAQSLKLNFDTGSADLWFASTLCTSCGSTQTKFNPNKSSTYQSSTKTWSIGYGDGSNASGVVGYDTVNLGGISIPNQGIELAKKESSSFQSDPIDGLVGLAFGSIITAKGVKTPMENMMSQNLIDSPVFGVWLGKQSNGGGGEYMFGGYNSAHIAGTLTTVPIDSSQGFWSINVSGTTAGTTSSVSSLGSFSGILDTGTTLMLFTNTMATKVAKVYGATDNGDGTYDINCNTSKFAPLSFTINGAKFSIPPADLIYYRSSSRCIAGFGYADLPFAILGDVFLKNNYVVFNQQVPNVRIAPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QDV3</accession>
    <name>A0A167QDV3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Probable valine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="4">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Valine--tRNA ligase, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHYBLDRAFT_105744</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="4"/>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297596.1">
        <property type="nucleotide sequence ID" value="XM_018427920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QDV3"/>
    <dbReference type="FunCoup" id="A0A167QDV3">
        <property type="interactions" value="889"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QDV3"/>
    <dbReference type="GeneID" id="28988826"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_105744"/>
    <dbReference type="InParanoid" id="A0A167QDV3"/>
    <dbReference type="OrthoDB" id="629407at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00817">
        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000009">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000020">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000078">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000005">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="17">
        <location>
            <begin position="108"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="18">
        <location>
            <begin position="777"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="46"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAD79556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="988" mass="111120" checksum="01B527D00A4E8988" modified="2016-07-06" version="1">MASNPKEETQAPPAVVEDAAAAAAAAAKKAKNEAKNEEKRLAKLAKFQAKQAKKTAAAETEVSEKKKKKAAKAAPAPAFVNTTPKGEKKDMSTPIANAYDPNAVESAWYEWWLKEGFFEPELTEDGKIKPEGLFVVPAPPPNVTGSLHIGHALTVAIQDTLIRWNRMLGKTVLFNPGTDHAGISCQSVVEKKLWKDHKKTRHDLGREAFIDEVWKWKEKFGNRIYEQFYRLGASYDWGRVAFTMDPKLSYAVRENFVRLHRDGTIYRANRLVNWCVHLNTALSNLEVDNKELPGRTLMNVAGYDPKEKFEFGVLNEFAYEVEGSNERIVVATTRIETMLGDTAIAVHPTDSRYTHLHGKFVKHPFIDRRIPIITDEIAVDMSFGTGAVKMTPAHDFNDYEVGKRHNLEFINLLNDDGTFNDNAGPYAGMKRFHVRTKIIEDLKAKGLFVGVKENPMAVPVCSKSGDVIEPLMKPQWWVNCKPMAAAAMKAVTDGELKISPKVSEADWFRWLGNIQDWCISRQLWWGHRVPVYFVNIEGEENDASDNHFWVSGQDEAAAKVEAEKRFPGKKFSLEQDPDVLDTWFSSGLWPFSIMGWPENTDDMQKYYPSSLLETGWDILFFWVARMVMLGIKLTGKVPFKEVFCHAMIRDAHGRKMSKTLGNVIDPVDVIEGISLDGLYQKLLDGNLDPKEVATAKAGQKADFPKGIPECGTDALRFALCAYTTGGRDINLDILRVEGYRKFCNKLWNATRFALMKLGDDFVPTADTTLTGYESLTDKWILHKLNNAAIETNKALAERSFKNATDAVYQFWLYDLCDVYIEVIKPICDADTTGNPAAANAKLAAQNTLYTCLEAGLKLMHPFTPFVTEELYQRLVRRSGDKVKSITKASYPVENKDYFNEEAEKSFDNVFEVIKVIRSLAVSQNKKKDGEVYIQTKDDKLASLLEKENLAVLTLCKGIKEVKVLKDSKVPEGCVSADVPNKATVWLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QM27</accession>
    <name>A0A167QM27_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_74178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297947.1">
        <property type="nucleotide sequence ID" value="XM_018442997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QM27"/>
    <dbReference type="GeneID" id="29003903"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_74178"/>
    <dbReference type="InParanoid" id="A0A167QM27"/>
    <dbReference type="OrthoDB" id="10582377at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD79907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="18807" checksum="EC96DD14A7B8431A" modified="2016-07-06" version="1">MLWDRTPARKRLNLFIPRRFPSSSCIFCQDATEDQYHFFFGCSIKRQVWNVILSRFCPAWNLAEICLLLTRGSFPPRSSHQGLWIILSAVTAKAIWSAHWKFVFDDQPFLSGVVAQKASTVIEKHIEFIIRITLVSRIPKKGQFKMSYLRLLEEKPTLYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QML4</accession>
    <name>A0A167QML4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar protein sorting-associated protein 28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_15137</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the VPS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297974.1">
        <property type="nucleotide sequence ID" value="XM_018432673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QML4"/>
    <dbReference type="FunCoup" id="A0A167QML4">
        <property type="interactions" value="362"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QML4"/>
    <dbReference type="GeneID" id="28993579"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_15137"/>
    <dbReference type="InParanoid" id="A0A167QML4"/>
    <dbReference type="OrthoDB" id="2671at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1130:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017899">
        <property type="entry name" value="VPS28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037206">
        <property type="entry name" value="VPS28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017898">
        <property type="entry name" value="VPS28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038358">
        <property type="entry name" value="VPS28_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017535">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140427">
        <property type="entry name" value="VPS28 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51310">
        <property type="entry name" value="VPS28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51313">
        <property type="entry name" value="VPS28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS28 N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 C-terminal" evidence="6">
        <location>
            <begin position="108"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD79934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24352" checksum="8C6FCAD375408744" modified="2016-07-06" version="1" fragment="single">EVRLFTNNKDRDKYDTMADLFAIIVLTEHLEKAFIRDSITAEEYTSQCANLIAKYKTTMNFLSESVTNLETFMDDYKLTCPAAVNRFKIGVPATYEHAIGNTKNDMGKAAKYIAESVLHFITLMDTLRLNRYAVDELHPILADLIQSLNNVPGLPAGFEGKTKVRQWLITLHSMKASDEITEEQARQMLFEMEQSHTEFYRLLSGEHKEEDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QNX8</accession>
    <name>A0A167QNX8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_157411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298024.1">
        <property type="nucleotide sequence ID" value="XM_018433613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QNX8"/>
    <dbReference type="STRING" id="763407.A0A167QNX8"/>
    <dbReference type="GeneID" id="28994519"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157411"/>
    <dbReference type="InParanoid" id="A0A167QNX8"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="190" mass="21133" checksum="4FEEE88FEB6BEE43" modified="2016-07-06" version="1">MSHPSMGYTPRPMVYAQPMIINHSNASYPSPPLPQPQQQQQQQPQQAQPQQQQHQQHTQTHPQVHPPMYVIQPNQQKQDGSAGQSMLPMAPNSAVYPTEVDSPATTPGGGEKRPKLRVQIPESAEDAAGRKPTEHNTNPSPSTFYPEFYQQNELPSPLNFSATPTANPGTFNWPPISRDYRPSPLVKVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QQV4</accession>
    <name>A0A167QQV4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_59143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298137.1">
        <property type="nucleotide sequence ID" value="XM_018440443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QQV4"/>
    <dbReference type="GeneID" id="29001349"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_59143"/>
    <dbReference type="InParanoid" id="A0A167QQV4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="149" mass="17113" checksum="80D43E3D585F0CFC" modified="2016-07-06" version="1">MSSEAIQRLVCLWLWANGAYKFSVCGVKFYRRKSTEYVLRCNKSNNQVSGSPHECNTAKYPSFSVRIKTEIYQKLCIVSVLYLLCQEEKAQDFIKGLLWYFRALGLPTKLAPYRSDTVYPAMIATTLSQYEYVLICDKSNIRVSGSPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QUE6</accession>
    <name>A0A167QUE6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_61335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298331.1">
        <property type="nucleotide sequence ID" value="XM_018440791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QUE6"/>
    <dbReference type="GeneID" id="29001697"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61335"/>
    <dbReference type="InParanoid" id="A0A167QUE6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="112" mass="12421" checksum="D3929AC4838BBAF2" modified="2016-07-06" version="1">MGILILRNGIILEGFGYRGIGSKISQETWETTLVPQNTSLGRLTVDVNAHESSITRHGSPPDQTTKGIHRPVSLTRNWPKLHMPTTHVTKEKCLLGSDHIASKVQKEDIKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167RFC1</accession>
    <name>A0A167RFC1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_139052</name>
        <name evidence="3" type="ORF">PHYBLDRAFT_139061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299550.1">
        <property type="nucleotide sequence ID" value="XM_018430145.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299558.1">
        <property type="nucleotide sequence ID" value="XM_018430150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167RFC1"/>
    <dbReference type="GeneID" id="28991051"/>
    <dbReference type="GeneID" id="28991056"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139052"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139061"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008241483" evidence="1">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD81510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD81518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="99" mass="11387" checksum="6A6B332947AA6594" modified="2016-07-06" version="1">MAIFSPVLLNFTLETLVLSIFANHTFLELTLHCSSPPLTIKLLTYTNDVFGCLFNPADITRLQNHLKLNVWPSNARINMHENHEISFSDDLFHHWNAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N2P6</accession>
    <name>A0A162N2P6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_150961</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285918.1">
        <property type="nucleotide sequence ID" value="XM_018432582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N2P6"/>
    <dbReference type="GeneID" id="28993488"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150961"/>
    <dbReference type="InParanoid" id="A0A162N2P6"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD67878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="289" mass="32536" checksum="DC56051A82C0F366" modified="2016-07-06" version="1">MPRDNLRRAIEDRYRLHRKIMREPENMSEESLLSTTHNNDGRVEPHDDQSYRSHTHSHAHRGHKLNPIPFFYNHGLTRTANPILNAQSGRRPISTGNPAVIGNWSFAVVTILLGTFNIFLPDKSNHIILPTAIMFGGLAQYVAGFIDLYFGGTFSGTILVSYGAFWTGSGMFMLPTVYPTLSSLDDERDLGRANAVYNFLWAAYTLMLAVISVKVKNGTFVLTWNLWWVFMTLLFTAIYNITDIVPILRVSGVFAYLAALGAFYSGIAIVMEEQGVQMWVGAFRPYSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N470</accession>
    <name>A0A162N470_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_68910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286398.1">
        <property type="nucleotide sequence ID" value="XM_018442028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N470"/>
    <dbReference type="GeneID" id="29002934"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_68910"/>
    <dbReference type="InParanoid" id="A0A162N470"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="178" mass="20477" checksum="39F2C00ABB250CDB" modified="2016-07-06" version="1">MKEILINDPSVYSQNFGQSRTSRLTSMSTTSKKKIEVLLEAVVSNNINDDHASNLNPVISNNKNEESLTATLLLTERSDYLASVNKILSTITYLHKETQDEVATERDVFISQLLETHEQRAAKQARDEKDRELIHKFTKACINELQHRQLQDNVILAEQKQLNDFLAQFLQSRYNNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N6E0</accession>
    <name>A0A162N6E0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_187610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289638.1">
        <property type="nucleotide sequence ID" value="XM_018439403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N6E0"/>
    <dbReference type="GeneID" id="29000309"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_187610"/>
    <dbReference type="InParanoid" id="A0A162N6E0"/>
    <dbReference type="OrthoDB" id="2289342at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="450" mass="51125" checksum="F7701243CBF8F0BB" modified="2016-07-06" version="1">MMNNKNDLSMSSSNTHTLFCIPKSQPDDELNAFDLTWRNYLPSMTQLCPCFGIFKGGSIQLDDDDESTGNLGPHYYNDQSIYQGRTIQGYLRNSRDREFESVLENGGGEDGAFSRGDYMPSFVTRNPFGRNRRKRPRRRKERAHLIQEEHDEPAVYEIFSEEQDRVDAESLGDDQIANLVFKPKTSDQYDEELYITVPRGGPKVQEMFPPTTHPGETTKYGLQSTPYLNDRMEIETEYDEDTGYEEDTEYENYRNNETDGCYDPDEPDEVDESDAGPVTRPTVAQTMLTEQLDDLTEKLVYIKRNIMDIGVKDSKVDPRTSAVLRPLKHLSMISNSERAMSDLDSIASEALEEYGNVVLNNKTISNHTAEEINHSRLGIRKNSGASDFNMPLADNHSTPFGSDQHPFTYFERSPVIASQTSSNRNSLGENQGLNVHSVFEFGKKWLNGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N915</accession>
    <name>A0A162N915_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_146440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290278.1">
        <property type="nucleotide sequence ID" value="XM_018431648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N915"/>
    <dbReference type="GeneID" id="28992554"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146440"/>
    <dbReference type="InParanoid" id="A0A162N915"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="152" mass="17323" checksum="EC590EAC5C4104BA" modified="2016-07-06" version="1">MHDHRIRTTDALLESHPHYGCVIRIASALRMRKLYLYLITLEKPLDYQMHYLKTINDYSFCDLLENKLFLSHMTTGYGTPHPQRPLFSHTSTTDTNMPRLHTHTLNISTSTTHTSTTHASTTHASTTHTSTTHTSTTHTSTTHTHISLIINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NGU0</accession>
    <name>A0A162NGU0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_144546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292128.1">
        <property type="nucleotide sequence ID" value="XM_018431234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NGU0"/>
    <dbReference type="GeneID" id="28992140"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144546"/>
    <dbReference type="InParanoid" id="A0A162NGU0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="57" mass="6437" checksum="8A09A7E42447FF14" modified="2016-07-06" version="1">MSKYPYWKDIHLSIITNQLADSKSFLALVLSSLLVFKYPESSVPKASMTMHLSLAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NI27</accession>
    <name>A0A162NI27_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_182656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287904.1">
        <property type="nucleotide sequence ID" value="XM_018438654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NI27"/>
    <dbReference type="GeneID" id="28999560"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_182656"/>
    <dbReference type="InParanoid" id="A0A162NI27"/>
    <dbReference type="OrthoDB" id="2235549at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="85" mass="8814" checksum="EF039C92F90A3930" modified="2016-07-06" version="1">MPALRAASYLIVPAVSAYGMAAYIRSSAQPAQAHSHLMSLNGSARDAQWRKINNGLGVDVGRSCGEINKAKQRRLFSAGAGAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PPK4</accession>
    <name>A0A162PPK4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase assembly protein COX16, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cytochrome c oxidase assembly protein cox16, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_114308</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COX16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289766.1">
        <property type="nucleotide sequence ID" value="XM_018428389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PPK4"/>
    <dbReference type="FunCoup" id="A0A162PPK4">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162PPK4"/>
    <dbReference type="GeneID" id="28989295"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_114308"/>
    <dbReference type="InParanoid" id="A0A162PPK4"/>
    <dbReference type="OrthoDB" id="5516033at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020164">
        <property type="entry name" value="Cyt_c_Oxase_assmbl_COX16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130:SF14">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX16 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14138">
        <property type="entry name" value="COX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD71726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="109" mass="12515" checksum="2892F6CC5DFEE396" modified="2016-07-06" version="1">MPTFQSKPFGRQSTLGPLAAKAKKHPFVLFGLPFLAIMIGGSFGLAQLTQTRYDHRDMRNTKLAKEDALGIDKNRRKLSLQEEYWRLQAKSDDDDDWEQVRIERPPGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PRD2</accession>
    <name>A0A162PRD2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_143544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293327.1">
        <property type="nucleotide sequence ID" value="XM_018431009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PRD2"/>
    <dbReference type="GeneID" id="28991915"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143544"/>
    <dbReference type="InParanoid" id="A0A162PRD2"/>
    <dbReference type="OrthoDB" id="3247418at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="338" mass="38764" checksum="DA47A24E3E08293F" modified="2016-07-06" version="1">MIYHKNCDDISLISYIFGTFDPDEITLFFQCMILPPDYISLRKTIGKGFPYMKADEWKTSCLVYRPILLQGRLPGAYLDNWTAFTNACQYLAKPSISNEEIDEAHNFERFNGTIKNYSTNRRDRFENTYMRRYIEDTYKGDLVCSLLPSILPAYANILLDLSSASASASASANSGMPQFNLDAFINVADRNIDIIKQNEPLLPSAYPLALTDETGFSQSFVNNWIKKIALINLLGQVYQSSHGNMQRRSFIQACFCTDDEDDNVEYTGQIQYLFYMPTEGSDDMNGRIELKEFKFSESNFQNILPVHRLYKPVAVDNYRCEDGITRMGVVLLLRKIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PSA7</accession>
    <name>A0A162PSA7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_146626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290476.1">
        <property type="nucleotide sequence ID" value="XM_018431690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PSA7"/>
    <dbReference type="GeneID" id="28992596"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146626"/>
    <dbReference type="InParanoid" id="A0A162PSA7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="69" mass="7952" checksum="F7E1498B39DA51FD" modified="2016-07-06" version="1">MNKPEKLCIGTWTWIEAKLRTGTRLWIRTSTLATMDTLNAAGACRWTFNILNSYPQTHQIANKKNRDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PUH9</accession>
    <name>A0A162PUH9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gem-associated protein 5 TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_143082</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294137.1">
        <property type="nucleotide sequence ID" value="XM_018430932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PUH9"/>
    <dbReference type="STRING" id="763407.A0A162PUH9"/>
    <dbReference type="GeneID" id="28991838"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143082"/>
    <dbReference type="InParanoid" id="A0A162PUH9"/>
    <dbReference type="OrthoDB" id="7326421at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052640">
        <property type="entry name" value="Gemin-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056421">
        <property type="entry name" value="TPR_GEMI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46362">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46362:SF1">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23774">
        <property type="entry name" value="TPR_GEMI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="592"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Gem-associated protein 5 TPR" evidence="3">
        <location>
            <begin position="831"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="691"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="737"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1048"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1048"/>
            <end position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD76097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1120" mass="124878" checksum="0F47C55F81B3C68A" modified="2016-07-06" version="1">MDNILPLCEAYPPAPNWYTSYAATTVEPHFYIYAARNSIVVLDMRTMQFRRTFLASLDKIQAVAAYEQFCFTGGVDPTIRAWNILDGNYITKYNSHNVEVTALLCIRNGTILISGDKSGCIVAQEAFGSIVVKKKQVKAEVRALAHTSFHDEDYIAVGYSNGMIRIEKLDAQLKLTTVYEMVDQINDVHSLAWQSLPSQTTESNPQWPLLASSFRHQKHVDLWNVPTESHCSKINLPSPGGQWSRNQKDTSWTELSWSPNDKDLLYMTSQSGAIICFNTKEPRKPVEVPKGGFGDKHTRVVFSMLWAYGKLSLNHFQIIKWNVKTHESVNCIKGHNGYPFSISISPLTPYQAVIGLGDSNIKIWTFSGEGKSMKKRKKHDFYESKIIWKGLQGQIEHVLWHPKRPDLLAYSTQYGRVGVYDANANKNTVFKTYHKQEYGPNISWGSLSSGTGSEYVLVSCGAEHIIAYDPMEPEKQPVFLAPLLENANPAWTQSINAKANAKRSCMAIDSTGKLIAFGYTDGVVDVYRLDTFKLVFVANCHRHCVLAIAWQSPTKFATGCRHGTVAIHTIPSTGLDNLPDIPLADSSASYVLSGHKKNITALAWSTHKDTPLLASVSVDMIACVWNEQSQKPIAWFREHRGRIFSVCWNILEPNEVFTCGDDRFIFKWKYTDHPFSPKLETEQSYYDKEISKLKTPKRNKTQEPTENGNSKNTASAANAAVIANSNATAFIATANTTAKTESVEGEPKPKKRKTKGSSLAYLGGKLENINHSTLQRYCLTLASKIYGGDPAETVKNVKSQLPSDLLSDQVDSYAKWVPFDDNTENSKAFLLFGGKNDVRLLLEEEDKQAYIKDSENPSTNDTRLWLGTTRGCAQSFGDIGNDFTDNSIADWIALALSPMNGKDAWINLMEKKAKKLAETDHHILAATCYIACSRICEAVEVCRKGSKFREAITIAKARMPQNENVLSTLFSEWGGALQKSDEEILAALCFLQSKRQGSVVNAIQLLARRNTDECLFWSACLAWLTKDSTVEECIKKWVSLVKEKDEQKDKVASKKKAEEADVPKIPENIKDSTSTACSSEEPINIENVVDIVIAESHVHMTAAGAEVDEEAATKTSEKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T5D3</accession>
    <name>A0A162T5D3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_175193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441003">
        <property type="protein sequence ID" value="OAD66382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284422.1">
        <property type="nucleotide sequence ID" value="XM_018437444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T5D3"/>
    <dbReference type="GeneID" id="28998350"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175193"/>
    <dbReference type="InParanoid" id="A0A162T5D3"/>
    <dbReference type="OrthoDB" id="2280588at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF34">
        <property type="entry name" value="NOTOCHORD-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="631" mass="72400" checksum="776CE098467CDFE6" modified="2016-07-06" version="1">MPTVHLRFLIANPSKAGKITSLPDWTPDQSISLQQGVKWKEHELYQQPMLTINNAIVWAGFLMKIYDAADNKQFLVKDFHTANCSTFARGYLATIDPNNVYYLDSATKDVKVEDLDTIDSAALGAIYVSHEPTSASGLNDYHYDLLYKDHCFKCLVLDSAHVANSGLYYKVRIAPIIFFTDDTSGNWSKQFNPYESWSMKLAGLSYEERSLIANKLFLLAIPKKNDVSGMSLLPTLIRDLKKLENDIVVYSAEDNAYILLVAPLLWIEADTPCHSELCDILGSATLYLCHKCYILIQRTVPLKEMEYYLKRHNKRTREHYVLANSTKNRTTIMPDVLNTGKPVNARALSFIDHSTGCLLDLKSFDLSKDTPIEILHAILLGIAKYLINGLVKITLKKHADKLEKLFKSLKECEQTTGLSRRFTQLLRHCESFLGRDYKVLLQTLPAIFLRDFADDEVIKPIMPCFVELGRLCSLIFVRQVESHFEEYLARVDYAVNDLIKELHTFDIWVATKEKELTQKDNYTPFCNKPKVHFLNHLTDNIRRFGPALNYETEKGKQFNKHIREHLIHTNRLNTSRDVCFKFAKQIIMQHIFDGGSWTNDNGQQEYSGSEIAECLKHNNVETFWHLFLGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TFT4</accession>
    <name>A0A162TFT4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_150437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286292.1">
        <property type="nucleotide sequence ID" value="XM_018432479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TFT4"/>
    <dbReference type="GeneID" id="28993385"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150437"/>
    <dbReference type="InParanoid" id="A0A162TFT4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="533" mass="58616" checksum="09637B0FF6A1DF35" modified="2016-07-06" version="1">MSKPVHSKNEILRSNTGLIINPLKAYPRSETKDKLTGLTIFQGVNDKNKISIQAYRDFSGKVKQSRTGFHPGPQCLPSRSSIRDPIRVYGLVSVPSRSSFKSYVKVHGFSIHSVQVKIQGPCQGPRFQYPFRPGQASRFRSRSTVSVSIPSRASFKVQVKVHSFSIYSIQGKLQGSGQGPRVQVEVHVSIPSRSSFKVQVKVHRFSIQSIQEKHQGSDLPAMVIATQVKCQGSDFPAMAIDVRRQGSDLPAKCSVIQVNQQDSDLPSMVIAIHVKRPGSDLPTIFTAIRVKRQEPDPPSMSPVINVKRQGPDRPSMVTVIQDKHHGFDLPAMVIAIQVKCQGPDRPAIVVQCSVIRMKRQGPDRTSMVIGSDLPAKDKHQGSDSPSIVIVIHVKHQGSDHPSIVIAIHVKPQGSDRPSMVIIFQVKHQDSDLPAISPAIQVKHQYSDLPAMSPAIRIKHQDSDLPAMGIAIQVKHQDSDLPAMAIQVKHQDSDLPAMVIGITKIDEQSHSALFISSVESTKIMLHGSGFSPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TGU0</accession>
    <name>A0A162TGU0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ndc10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_173463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286512.1">
        <property type="nucleotide sequence ID" value="XM_018437038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TGU0"/>
    <dbReference type="GeneID" id="28997944"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_173463"/>
    <dbReference type="InParanoid" id="A0A162TGU0"/>
    <dbReference type="OrthoDB" id="2284230at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="16048" checksum="5B29E16F18184C81" modified="2016-07-06" version="1">MNYTEASSSTQTNVLNNDYYQCNMENWLTTQQNSEMIVAENQLFHPKNTTHTYLAKQKEWMFNLYQEFEAQLSGAIGESTKKFQVSDHIQVVAPEIAAAMQAQNQFEFANARSVGLETRNVLVETFLQASFYLCNDPSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TIE7</accession>
    <name>A0A162TIE7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_63596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285443.1">
        <property type="nucleotide sequence ID" value="XM_018441145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TIE7"/>
    <dbReference type="STRING" id="763407.A0A162TIE7"/>
    <dbReference type="GeneID" id="29002051"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63596"/>
    <dbReference type="InParanoid" id="A0A162TIE7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="277" mass="30633" checksum="2D7323922C459867" modified="2016-07-06" version="1">MVLQAAGAGIAIFESTSKDSLMASKYVPKALMVDTNSSIFILCANCSITTNSNKNNEKSDPQNKTDSNVAAGQISYVTQAKKSIDAKQTKQKRQQLLQKPTGPSEYEFVYFLAKRYIKYQEMRKILSSFNMPTSCILDIQFPARWTVALLIIGEFHEELSALLGKAKVVPLGNFNLITSDIIADLKLKEEAIKVRARKAQNLFDTCLIKASLCMSTYLGHSDICHFSSKRAVVKILQTAVSGYPQSQKTISTTTSIAPTNNMNGIESTKMSIIRTHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TKH2</accession>
    <name>A0A162TKH2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_150927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285883.1">
        <property type="nucleotide sequence ID" value="XM_018432574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TKH2"/>
    <dbReference type="GeneID" id="28993480"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150927"/>
    <dbReference type="InParanoid" id="A0A162TKH2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007840012" evidence="1">
        <location>
            <begin position="22"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="141" mass="15997" checksum="5E416956F2501234" modified="2016-07-06" version="1">MPHLQNFAVFLLKGFISFSFGVDRLKFVHTSCTEFRNNQQQPQALAETDSNFSEARNRILTYNTQENNSSVAKCHLSEPVPATMSLQAPTDTRWVDYVIRWLPRDVCPISPSKHRNTWLTIIITINGRDKLDSSAPVTATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TQR7</accession>
    <name>A0A162TQR7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS17 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_182574</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288362.1">
        <property type="nucleotide sequence ID" value="XM_018438641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TQR7"/>
    <dbReference type="FunCoup" id="A0A162TQR7">
        <property type="interactions" value="541"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TQR7"/>
    <dbReference type="GeneID" id="28999547"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_182574"/>
    <dbReference type="InParanoid" id="A0A162TQR7"/>
    <dbReference type="OrthoDB" id="10254436at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000001">
        <property type="entry name" value="40S ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_uS17_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="5">
        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD70322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="151" mass="17337" checksum="0DF0873516362A6E" modified="2016-07-06" version="1">MSEQTEKAFQKQAGIFQNSKISAKRNQRWYKDVGLGFKTPKEAKSGSYIDKKCPFTGEVNVQGRILIGVVVSTKMKRTIVVRRDYLHYVPKYNRYEKRHKNISAHLSPAFDHVESGDIVTIGQCRPLSKTVRFNVLKVQKAKKTGKAFQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TTG5</accession>
    <name>A0A162TTG5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_66108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287713.1">
        <property type="nucleotide sequence ID" value="XM_018441585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TTG5"/>
    <dbReference type="GeneID" id="29002491"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_66108"/>
    <dbReference type="InParanoid" id="A0A162TTG5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="162" mass="18742" checksum="51A4E748B6F3946C" modified="2016-07-06" version="1">MHIPTKAKWHSIGHKVLALEQWSFKGGFRVVFWLSIVIFIFLCFNTYPSYCACRHYFHTVTLKKSVSWIPYAPNLRNTREPLGNCDILPEVQGSSKISTPQDDVQAVNQAIPFKYFGLVYLKRKFVKNNNQMISGHIITFESRVKLNVMLGSICIVKCWRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TZ70</accession>
    <name>A0A162TZ70_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_148239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD71023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289063.1">
        <property type="nucleotide sequence ID" value="XM_018432042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TZ70"/>
    <dbReference type="GeneID" id="28992948"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148239"/>
    <dbReference type="InParanoid" id="A0A162TZ70"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="96" mass="10815" checksum="17EBC40FEB5D2181" modified="2016-07-06" version="1">MDLGDVMSSMQNYGPPHSKLLLLPRLLIHRNMYVNFVLRTRRSLSRLRERQKCTNAEKITPIAKLVAKGVSNFCYATPHSLKVVIAPSLVQLVTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TZW3</accession>
    <name>A0A162TZW3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_114627</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289233.1">
        <property type="nucleotide sequence ID" value="XM_018428406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TZW3"/>
    <dbReference type="STRING" id="763407.A0A162TZW3"/>
    <dbReference type="GeneID" id="28989312"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_114627"/>
    <dbReference type="InParanoid" id="A0A162TZW3"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD71193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="497" mass="54540" checksum="799E75C516DB8230" modified="2016-07-06" version="1">MSQADQQRQGSLLISTMMAAAFVGSLAAGPLADIIGRKGLTLLGTTIFVFGDVLQVGADSIAMVYGGRVMTGTSDDICSYQSEIAPKEMRGRLVSTIQLSIGLGMGLAYWIDYAGLKVQGSMSWRLPFGLQLIPAIIFFVGMLATPESPRYLVQKQQDRRAIEVLALIRGDGKRDHPDVLMEFTEIKQSITYERQHTSGDYWYLFKRGNDNNQRRLLLGMAVQIFQQLTGVNAIMLYAPMLFETTGASGGNATLFANGISGIINCVSAIPPLIIMDRWGRRPTLVMGSIICSMCLIVMSIISGIHGTVEANDSAKPTGSLADESSLTLLALDGRGYTIAFMVTMYVYIFSYGCSWGPAGWAYPTELYSQGKYKALGITSAASWIATFAVIQLSPFILDQVQWKFYTIYAVICAVLALVIYKYLPETMGKSLEEVDLIFTCDFNTYDHAVHHPQTAAEALERLEHMHNKQSHLFNFGTSGISNNLPPNAIRPDNTNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U2Z7</accession>
    <name>A0A162U2Z7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_146937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD71953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289993.1">
        <property type="nucleotide sequence ID" value="XM_018431760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U2Z7"/>
    <dbReference type="STRING" id="763407.A0A162U2Z7"/>
    <dbReference type="GeneID" id="28992666"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146937"/>
    <dbReference type="InParanoid" id="A0A162U2Z7"/>
    <dbReference type="OrthoDB" id="2285175at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="166" mass="18134" checksum="96BB4EC699C6E30C" modified="2016-07-06" version="1">MGNLTGVLGARFPKKPGGTTLVPRDLSLGQLIIDINAHESGTAHHDSLLDQTTKEILHLYSGSTSRCGRADPGSIPVPGVDTILFLPASHVERGCLIRWRMGWLLGKPKECPGGSDYTSRCHLLNCPLVPATLFEQLPQPNYDQIHRIDFAITSLPLTSQELRPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U595</accession>
    <name>A0A162U595_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_168886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291582.1">
        <property type="nucleotide sequence ID" value="XM_018435960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U595"/>
    <dbReference type="GeneID" id="28996866"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168886"/>
    <dbReference type="InParanoid" id="A0A162U595"/>
    <dbReference type="OrthoDB" id="2253782at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="250"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="887" mass="103356" checksum="E96E4E2E2F4F21EA" modified="2016-07-06" version="1">MLKKRFIFYEVFNYISSRCRSLKHMTLDKLSILGSISKKTGFLLVDMPYTFLKTLEIGQVPYSTLEYSFFMDTNIDEKDERKRNENDSEYPISASHIIDWISVYKYIKRNRDKYLTTTKLSNKGATITLEYYQDFQSNKTDQILEDFGLYDEADQSICDKCNLSEGCGELRFGKVETVHVVRDSSLGKDINSERAKSLIKTPKLKSKIYKLQLSSNQFDDRNNCSELDSTFHFARSRLCSKSQMSKFLTLNTISELPFEILAQIADKLSTTDRLTCALTCKGWRYLFQKALLRDMQIYSYYKIQETINEIRTYRNESTSLPLLVYSLKIQHYYNMTEISSIAFSDLFVYLPNLKALELCVEPYIDIEVEIPLPKKIWKSLESLKIQYRGIYDTRPAIHLCRFINTYHMVQRLELLDEGNFGCIEFSVNDFENMHQNIRNLSSIKASIYLSPYTWSRLDNFSDTMPAFAVTSLDINFKNKSIKFSSSSQNKWNPLWLSYFGYKYPNLRSLKLTTTNTWGNSTNSDERQTIISLFQSNPNAFRHLKTFSFTVNNHFALSDLVILELLCVLRAPLRHVALNTTRNQEADCSYPLNVNRILRSFSKTLESLLLTGFTYSNHTKNPVLKLSLYCPLLTNLCIIGRNISLNLKDLLNKCVALKQLKFGGGKLFTNLNMTTKEPEQQQKEHGLQILSLEKCSANASTFKHISFRCKNLQHMTLNIVSVTELIWETTGYFLLDMSHTFLRTLKIGRIRYEISNRYIKKKDYICLTLLSQLNGHRLADKKKIDTEYPKYPYHNIDWLYTYKYCVRDDIYLLITKILPKNGANIALESYQNSRSKKAGPALKGANLYEGNDPKVYWECELFKGFGELRFGNIESVSYISQTYYRKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U7T0</accession>
    <name>A0A162U7T0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_146376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD73063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291103.1">
        <property type="nucleotide sequence ID" value="XM_018431633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U7T0"/>
    <dbReference type="GeneID" id="28992539"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146376"/>
    <dbReference type="InParanoid" id="A0A162U7T0"/>
    <dbReference type="OrthoDB" id="2290056at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="589" mass="65894" checksum="775D184EBCB33070" modified="2016-07-06" version="1">MSSEHLNGKSPVLFAQTDLSRMDASANTQADTSLQAIGRICNVVATCSTALADAIEQNLLKERKNQIGQTITTMEGNLTILISVHGHLLRSSLPSAEQETRQSHVVPRELPIFQWHVNKWDTTQKVYSSIEECLDKFENVLHLYSLDLNVDWHHLLPIVLSREQHFWYDNYLCSSPELPWSFACDAFICVYSINDLECQIQLTHELMLMRMRAIESVTDNMQTTIAYTATLLPELARQVSLLQVNMPREKRDTIHKMASLARLIYNTVSHTPTHPSSAHSSGFSCETTPSCECSSSKKCLLHGKNNYDTEDCHILKTALATKGGNQMEKTPHINKYFFGFCVWLFLEICPHFAICSAHAVTSDNTPLEASSSEDDQFMVIDFEQCSPYTGATISSVNTKLCSKFGWSIIPCKGKIVLATSNAIAHRLEVTKPIKVFYNNKHITHSFEVLDLAENIDVSIGTDLMPSLGIHLLGLAESWYGSNTPQTPTPIAEIEKPNNSPARTPTEHSQFMKALLPFIKANEDIPITLFCIVKESIVQLPTPPDEFGNLTGKRPCLDLRAINTLLSDDRFPLPLISELFHRCGISGTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UER8</accession>
    <name>A0A162UER8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_145026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292633.1">
        <property type="nucleotide sequence ID" value="XM_018431351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UER8"/>
    <dbReference type="GeneID" id="28992257"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145026"/>
    <dbReference type="InParanoid" id="A0A162UER8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="208" mass="24079" checksum="2D2223BDE04AAC13" modified="2016-07-06" version="1">MENILLCKAGIQHCLGGRAAQRRLTDRRTSNFEVVSNNVASPQLWSNLIRKSLASIAIKCYMNYHNLVSLLTCLWDQNSTGMEQEIIEVVCITKMWKDNVMYRVRTSFDSRHVQANDLVVLKHPEEYGYVIKFFSHSVLGETRLFVVVDCLQDVWIYNELLFSVWESQTIGEMKVVEVKSIRGMAGLVHDINDTTIRHVVWTSPRHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UJB9</accession>
    <name>A0A162UJB9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_166931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293743.1">
        <property type="nucleotide sequence ID" value="XM_018435531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UJB9"/>
    <dbReference type="GeneID" id="28996437"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166931"/>
    <dbReference type="InParanoid" id="A0A162UJB9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="266" mass="29924" checksum="B42CBA312CC804C8" modified="2016-07-06" version="1">MSSNTQQSKKTKKTTTKKSVQQTAETAASTRQWEILPSLTVSAELDGTVLSTLSTMSTRLNEYHSLLEKVYHNMEATNGQNNNSNHSPISQALTTGEYIKHRLPTVLRLIHSQTRAVLSTMPLTVNEGAFSTSNHPIADGKSFARKDSSTKSNFLMPVQKEKYYKTIHLADKANLESKFGETVVGLLDYDMLSNIESDEEKNKTRYTPRNRHPLVDKYFTVLKKQRLANKGPDVIGNSVYPIILRNTELSNEKKAHVAAWIHTCQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UN69</accession>
    <name>A0A162UN69_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_165633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295182.1">
        <property type="nucleotide sequence ID" value="XM_018435269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UN69"/>
    <dbReference type="GeneID" id="28996175"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165633"/>
    <dbReference type="InParanoid" id="A0A162UN69"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="172" mass="19780" checksum="6487D06A7784CBBF" modified="2016-07-06" version="1">MSCHAKLIGKQTPLLTRTLLLSGWVRLCFYNIDFKNPVSITLKIKREIHANNNKGDGCKRNQYKPQKVAKEEKKALNLLKGCVILYIMLPLLDNKILSDALYSNIQPSLRTNLFCWDLQIILHFHIQIIIPGIFIREKNIVLCDTGWWAGRQELDYLKRNTPFNGGCIDAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UN96</accession>
    <name>A0A162UN96_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bifunctional lycopene cyclase/phytoene synthase</fullName>
            <ecNumber evidence="8">2.5.1.32</ecNumber>
            <ecNumber evidence="7">5.5.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">CarRA</name>
        <name evidence="20" type="ORF">PHYBLDRAFT_180114</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 (2E,6E,10E)-geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34475"/>
            <dbReference type="ChEBI" id="CHEBI:27787"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="EC" id="2.5.1.32"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>all-trans-lycopene = gamma-carotene</text>
            <dbReference type="Rhea" id="RHEA:32219"/>
            <dbReference type="ChEBI" id="CHEBI:15948"/>
            <dbReference type="ChEBI" id="CHEBI:27740"/>
            <dbReference type="EC" id="5.5.1.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>gamma-carotene = all-trans-beta-carotene</text>
            <dbReference type="Rhea" id="RHEA:32239"/>
            <dbReference type="ChEBI" id="CHEBI:17579"/>
            <dbReference type="ChEBI" id="CHEBI:27740"/>
            <dbReference type="EC" id="5.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carotenoid biosynthesis; beta-carotene biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carotenoid biosynthesis; phytoene biosynthesis; all-trans-phytoene from geranylgeranyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the lycopene beta-cyclase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.32" evidence="8"/>
    <dbReference type="EC" id="5.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294563.1">
        <property type="nucleotide sequence ID" value="XM_018438264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UN96"/>
    <dbReference type="SMR" id="A0A162UN96"/>
    <dbReference type="STRING" id="763407.A0A162UN96"/>
    <dbReference type="GeneID" id="28999170"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_180114"/>
    <dbReference type="InParanoid" id="A0A162UN96"/>
    <dbReference type="OrthoDB" id="6600518at2759"/>
    <dbReference type="UniPathway" id="UPA00799">
        <property type="reaction ID" value="UER00773"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00802"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:geranylgeranyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045436">
        <property type="term" value="F:lycopene beta cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000020">
        <property type="entry name" value="Phytoene synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017825">
        <property type="entry name" value="Lycopene_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03462">
        <property type="entry name" value="CarR_dom_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31480">
        <property type="entry name" value="BIFUNCTIONAL LYCOPENE CYCLASE/PHYTOENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00018909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OAD76523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="602" mass="68670" checksum="FF2C7525405D7F99" modified="2016-07-06" version="1">MLTYMEVHLYFTLPVLALLAFLYKPFFTTKDRFKYIFLCTVAFATASPWDNYIVYHKAWSYCPECVTAVIGYVPLEEYMFFIIMTLITVTFTSLTMRWTLPSFFIRPETPVFQSVCVRYIPIVGFLTIAAKAWASSIPDSHPFYGACILWYVCPVLALLWIGSGEYMLRRWKAVLFSIAVPTIFLCWVDQYAIARGTWDISRRTSTGIMVLPSLPLEEFLFFLLIDTVLVFASCATDRAHAIVHIYITPMNHNKVSTWYMDFFYLCWAFLQTDQALSGETLSDLDATWRILREASASFYTASSVFSFEARQDLGVLYGFCRATDDLADNNDVSVPDRKKQLELVRGFVRQMFDSKHGHPDIDWTQYSGSIPDSFIAAFRSFTRLRDVLEIKAVEELLDGYTFDLEQREVKNEDDLVYYSACVASSVGEMCTRVLMASEPGGNRTMLKWTVERARDMGLALQLTNIARDIVTDSKQLGRSYVPRDWLTSQESALLKAGKARELGDERLRQIALKMVYTADDLNLMASRAIDYLPPSSRCGVRAACNVYTAIGVSLHKANGYPDRAHLTKLERMKVTFRCVYGFRKGHQGVQGDRGKSQAFTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UQG3</accession>
    <name>A0A162UQG3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_158069</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295123.1">
        <property type="nucleotide sequence ID" value="XM_018433727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UQG3"/>
    <dbReference type="STRING" id="763407.A0A162UQG3"/>
    <dbReference type="GeneID" id="28994633"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_158069"/>
    <dbReference type="InParanoid" id="A0A162UQG3"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007747945" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD77083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="520" mass="57873" checksum="7B5244981BE783E8" modified="2016-07-06" version="1">MPSIASIAKLAIGAAILASAVVAEPQLVLQQQGDLSASWGNVHDILQSSVQGSIETAKKMFGDKIDEARHSIKDSFKAFTHPAFPEYGMRYKEPALCDPDVRQISGYLDVDDDKHFFFWFFESRDKPAEDPLVLWLNGGPGCSSLTGLFMELGPCTVNLPGNDTIPNKYSWNNNANVIFLDQPINVGYSYGSRGASNSLAAAKDVNAFLQLFLKEFSEYSHLDFHISGESYAGHYIPAIAGVINRQNNGEYLSASLQTQASTLSTINLKSLLIGNGLTDPLIQYKYYAQMACDNSYGPTLDRSTCDQMEAQYPACARLIENCYKSKSVFACLPAAMKCNKDQIQPYQQTGKNPYDVREDCKGGGGLCYEILDSVQTYLNREDVKKAVGAQTESYESCNMQINFRFQMAGDWMLPYVNEIAPLLEDKIRILIYAGDADFICNWMGNKAWTLELPWSGQQEFVSAEDEDWISEITGEKAGELRTTEDGLFAFLRVYGAGHMVPYDQPEHGLDMLNGWIRGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UU67</accession>
    <name>A0A162UU67_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ndc10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_141892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD78032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296072.1">
        <property type="nucleotide sequence ID" value="XM_018430689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UU67"/>
    <dbReference type="STRING" id="763407.A0A162UU67"/>
    <dbReference type="GeneID" id="28991595"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141892"/>
    <dbReference type="InParanoid" id="A0A162UU67"/>
    <dbReference type="OrthoDB" id="2277573at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.20">
        <property type="entry name" value="Centromere DNA-binding protein complex CBF3 subunit, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038279">
        <property type="entry name" value="Ndc10_dom2_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30346" checksum="C3ECE96A74A9751C" modified="2016-07-06" version="1">MNGQNNNSTNAMVNNISLQRMMDNRSAMHTRSQLVLAQNMELCPKNTSKAYAAKQEEWRRGCKLKRAEDGSPIPLGRESILAYVKAVSDICSKKKALGWNPNGVARGSLVRAFLDTSSKKRSQAVRTNFEDRRKNTLNDGYTRQKLEKISHYFLNKSNIRGCRDRLCFLISHSMLFRSQTGVTECIALVATITFGKTNQHGKIEYGSSAHHFQVDVCSAYEDRFTPIQYKAQHKTFAKDFKAVGLHTSKVTQGNCKSALNTIVQENISGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UVW1</accession>
    <name>A0A162UVW1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_179519</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296362.1">
        <property type="nucleotide sequence ID" value="XM_018438161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UVW1"/>
    <dbReference type="FunCoup" id="A0A162UVW1">
        <property type="interactions" value="463"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UVW1"/>
    <dbReference type="GeneID" id="28999067"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179519"/>
    <dbReference type="InParanoid" id="A0A162UVW1"/>
    <dbReference type="OrthoDB" id="201398at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12240">
        <property type="entry name" value="RRM_NCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000399">
        <property type="entry name" value="Nuclear cap-binding protein subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034148">
        <property type="entry name" value="NCBP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="34"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="161"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD78322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="218" mass="25467" checksum="FE6B90F283672D30" modified="2016-07-06" version="1">MATLVNSLAVPSTYRDQLYQGTSNQFVDDLSATTTLYVGNLSFYTTEEQIYELFSKCGEIKRIIMGLDRNQKTPCGFCFVEYYHRTDALDCMKYVNGSKLDERVIRCDLDPGFKEGRQFGRGRSGGQVRDEYRTEYDSGRGGWGHRTRAQLEREREMDIKENYEPIKEVPQGAGEYKSRVPMTGMNKRSRDYEQPENRKRHKEQNPRFRENEGEDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UWL1</accession>
    <name>A0A162UWL1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_140530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296493.1">
        <property type="nucleotide sequence ID" value="XM_018430422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UWL1"/>
    <dbReference type="STRING" id="763407.A0A162UWL1"/>
    <dbReference type="GeneID" id="28991328"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_140530"/>
    <dbReference type="InParanoid" id="A0A162UWL1"/>
    <dbReference type="OrthoDB" id="2430203at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="356" mass="41435" checksum="6746643C20777797" modified="2016-07-06" version="1">MSFVGIELTIYRLLYDTNALLNSPTEGIKMLPLNVVVKVKASEWELCLDRIQSLCSTKWNKCRKLRARELMYGETKKCHREGFYISDRNVCFAQKDTKLCYCEVTIFIKQYINNPEVILICMINDHTNYVSGDASEIRTLPLPSEAIKIIEDQLKGGSTCRNTRISMKNFLYKFHPDENKSLDIWMREKLPSQNYCIFSGDLSACNNNAQHFAFGFQSSSQMMLMRISESFCLDATHNISARNIEILYSLVTHHSDTAKGSSVAYIITNDHSVGPINQWLHNLDSKVKLDASYTSEQPGKYKYELKEFRHYIQSQQQFLAYFEHKLIGTEELLRRWERPYVANDHQRYLTNNYIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UZC9</accession>
    <name>A0A162UZC9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_141040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297023.1">
        <property type="nucleotide sequence ID" value="XM_018430513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UZC9"/>
    <dbReference type="GeneID" id="28991419"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141040"/>
    <dbReference type="InParanoid" id="A0A162UZC9"/>
    <dbReference type="OrthoDB" id="2266637at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="145" mass="16886" checksum="AAB662F2327B5E3F" modified="2016-07-06" version="1">MDNAPIHKYEDIQLSIERRVYGCVYLPPYFPELNPIEQFLSVVKKNKFSSARAQNKGLSSYLKSLDLKGKLSPKQTESEHNTTSKMENLDQTATTIDRTYTDVKEVEKLNHGTNCHLFFPFLVAKIRREDLLEQIEPKLDYEDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V157</accession>
    <name>A0A162V157_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trafficking protein particle complex subunit 2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_179065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. Sedlin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297333.1">
        <property type="nucleotide sequence ID" value="XM_018438096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V157"/>
    <dbReference type="FunCoup" id="A0A162V157">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162V157"/>
    <dbReference type="GeneID" id="28999002"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179065"/>
    <dbReference type="InParanoid" id="A0A162V157"/>
    <dbReference type="OrthoDB" id="18320at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14854">
        <property type="entry name" value="TRAPPC2L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044760">
        <property type="entry name" value="TRAPPC2L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD79293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="148" mass="16661" checksum="B7A3AE9251E2EB85" modified="2016-07-06" version="1">MSSEINCIALIGKQNNPLYIKNFSNTHPDLKYHYIAHTSIDVIEERVSNGPKNLDLYIGLLYAMEDLAVYGYITNTRVKCVVVVSVTDCVIRDADMKLIFQKVHAAYVNQVCNPFYNLDSQKSLTSKAFIRAIDAIGLTKPTRTTLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V5C1</accession>
    <name>A0A162V5C1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_157439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298132.1">
        <property type="nucleotide sequence ID" value="XM_018433614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V5C1"/>
    <dbReference type="GeneID" id="28994520"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157439"/>
    <dbReference type="InParanoid" id="A0A162V5C1"/>
    <dbReference type="OrthoDB" id="2404451at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="124" mass="14285" checksum="7AB7804C0A563D62" modified="2016-07-06" version="1">MFTCPYRNNRNVIVHSWLVGTVQFYFQHVDFYGFPHFLAFVEVMKEHDAAGHDSSVPIVKQRSQSTRTLGHQTQPTYAVISVNDICYQVGLVQYPPNGNQFYVIALYYIFNNNMCITKGNLSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162VA19</accession>
    <name>A0A162VA19_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_7430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299182.1">
        <property type="nucleotide sequence ID" value="XM_018443008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162VA19"/>
    <dbReference type="STRING" id="763407.A0A162VA19"/>
    <dbReference type="GeneID" id="29003914"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_7430"/>
    <dbReference type="InParanoid" id="A0A162VA19"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF28">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF21B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD81142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="90" mass="9796" checksum="169381FA5E6ABD1A" modified="2016-07-06" version="1" fragment="single">KRTNAQGDRAKEGIAINSGLLTLGNVISALGDETRRAAHVPYRDSKLTRLLQDSLGGNSQTMMMACVSPADTNFMETLNTLKYANRARNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162W790</accession>
    <name>A0A162W790_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_153801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441019">
        <property type="protein sequence ID" value="OAD65095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283135.1">
        <property type="nucleotide sequence ID" value="XM_018433258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162W790"/>
    <dbReference type="STRING" id="763407.A0A162W790"/>
    <dbReference type="GeneID" id="28994164"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153801"/>
    <dbReference type="InParanoid" id="A0A162W790"/>
    <dbReference type="OrthoDB" id="2279446at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10423" checksum="D7971F204E2AE821" modified="2016-07-06" version="1">MEQFKGGTWTSSAAVDYTTSWTIACVVPVASAQIVAAFIYEEIVMRFGCPAEILRDRGANFTRKRMDAYLIRTKSNHRPTFAFTHAQMVNLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WFC0</accession>
    <name>A0A162WFC0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_152035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441000">
        <property type="protein sequence ID" value="OAD66765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284805.1">
        <property type="nucleotide sequence ID" value="XM_018432819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WFC0"/>
    <dbReference type="GeneID" id="28993725"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152035"/>
    <dbReference type="InParanoid" id="A0A162WFC0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="213" mass="23553" checksum="9258F613E89AEE48" modified="2016-07-06" version="1">MTNSLVILHCVMTTVIKDIADIKAKTLDTSVSAVLQSQPMALVHTVPLVSMEINVAGSPIIAFDARSSPNTELTENLIAYLERNFIGEGLRESDVRNFVYMNFTSRKRAAKKSQTKKKSENACNRRSSREKESNKTDIDDKMKRDRSGLIIEEAMSVGESDDGTLPHYNHFITLVDKKVVADLGSNSHQLLSHAFGKTIEGPVSDAIVSQFPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WJ43</accession>
    <name>A0A162WJ43_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_174171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285515.1">
        <property type="nucleotide sequence ID" value="XM_018437204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WJ43"/>
    <dbReference type="GeneID" id="28998110"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174171"/>
    <dbReference type="InParanoid" id="A0A162WJ43"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="193" mass="22467" checksum="61FC51F644FC58D1" modified="2016-07-06" version="1">MRSSNVLVCYVDNAIRHWSMSVKAPRAYIGACGETLSLLEDLKKDHKATLRSEDISRLSFSHTIDLVIIRLVEGSHENIAAGRMYEETFELVNVYYKKRKKYYFCLARSVHPIFPPTAGNHFQKTFNHQTKKRLRLEVLWTTTEPKLTTGAYTFFLIYVTNIRAKSTFNIFFNNHAAALPKRNVSYRVQKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162X0L5</accession>
    <name>A0A162X0L5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="22">DsRNA-specific ribonuclease III dicer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">Dcl</name>
        <name evidence="22" type="ORF">PHYBLDRAFT_85799</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="15 16">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289885.1">
        <property type="nucleotide sequence ID" value="XM_018443620.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A162X0L5">
        <property type="interactions" value="330"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162X0L5"/>
    <dbReference type="GeneID" id="29004525"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_85799"/>
    <dbReference type="InParanoid" id="A0A162X0L5"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000628">
        <property type="entry name" value="Endoribonuclease Dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000004">
        <property type="entry name" value="Endoribonuclease dicer-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.380:FF:000001">
        <property type="entry name" value="Endoribonuclease dicer-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="97"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="412"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="21">
        <location>
            <begin position="617"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="PAZ" evidence="18">
        <location>
            <begin position="950"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="17">
        <location>
            <begin position="1123"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="17">
        <location>
            <begin position="1296"/>
            <end position="1444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00035116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OAD71845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1568" mass="179175" checksum="D77E853588A3DFD0" modified="2016-07-06" version="1">MAVAAESIVFNDEDNGDSIAYVAPEPVVNDMNDHGQERLLKYLDPEFLDATPDSKTKFAEEIEAEEEFDLDEDLEENEGEDDKLITMMCPREYQFELYQRALEDNVIAVLDTGSGKTLISVMLIKEIAAREREARMTRRSTKLAFFLVDRVPLVFQQSEVIKANCDVVLEQMCGEMNVDNWSEKKWKTIYEESDVCVMTAQIFLDTLRHGFITLNSVNLIVFDECHHATKKHPYNLIMREFYDRCRADERPKIFGMTASPMHSKTGVYFSATQLEQNLNSRIYTAANLEELQTAIKLPDEYEASFSPSPGFPPTELTRRAREKLSHIKRFERVFQVTTEVADHLGPWCGDRLWQSILENMVDKMLLDTKGQPRENLCDDDQALYEIYQLSLAEAPSNPDITNKRIFTPKTMKLLQLLKVLQHLPEFCGIIFVERRHTAIALNLLIKSIDLFKIFRCDLLIGHGSSEEGDTKMRYQDQNRMIKKFRSGELNLLIATNVAEEGLDIQPCNVVIRFDFFTTLIAYIQSRGRARKPDSKYIILTDESNMGQRGMLSRFRDLENEMKDFCRMLPEDRNVANKFLQGMPLTDDSGDSDDSEDEDCEKVFIVPATGAMITMESAVPLLHRYCGTLPSDQFSLLKPVFEITSTSDGFQCIVHLPTNAVVTGATSQPTQTKTTAKKLAALETCILLFEAKAFNDHLLPNNPKRELLGEMAPLLDKNGLVVGSRRRRGVYEKRTPRFWKPIVEELELEDEELKPSDPQDDAVFDTNPETALVNLQPRIKPEKKKKSGLSHMPLIIDEIEDVDGLLNPENQPEEGVDPKLILPILEEEDDGPFTLWFSVIEVNVGQMFEGHVRRMCLLTWKPFPDLPEIELYSKGETFTAIVRPLEESVDYDTDTILALSHYNLKLSAAVTNKEFVCQVRNFPYFIIPLTVYNDQEIAEDLSTLKACQDKIDWEEIKRTVEQKDSKIDLTNSSDLTLDDSIITDPADGNRRYFVRQVVHEMRPQSDIPPTEGKNREAGYTTFEEYYEKEHDLHVTLPEQPLVSVQKVSKMMNYLQPTVGMMAQQKGRTANYVIPEFCHKVPISASVYQSMMLIPSLMTRLDSFLLANEARERYKIPITDIQMLEAYTAPSASMKMDYERLETLGDSLLKFIATIRLYINFPFCHEGELHCLRIRVICNRALYRSAKRLKIYRYVTSQAFNRRYWRPHGFVAKSDTPDTLKETKTHMLSDKTLADVVEATLGAAYLSSGLEGGLETAIAMQIPFDDMKKWGDFLPTYIDSRKSVPARAEIKALRSVNLPKVYEAAGYTFKQPLLLVEALTHASLPNSTAPCYQRLEFLGDAILDFLVIRYLFTKYPTFDPGMITDIKDSCVNNHVLGIICIETGMHKHIIHYSSRLIRAIEHFVSEVDDLKKKGEAVGEYWRDFSIPKVLSDIVESMLGAVFVDAGFNLEPVEKLFDLWIRPIFDKYVTPELIRIHPLRQFTTDLQKFGCEGFMLRNHTSTGTGPKSQKCVIFLHDKPLACGAADNVKAARRFAAAKANERLKDEPDLLKRVCNCSIGLRRQMQVEEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162X996</accession>
    <name>A0A162X996_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_133789</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291385.1">
        <property type="nucleotide sequence ID" value="XM_018429594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162X996"/>
    <dbReference type="FunCoup" id="A0A162X996">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162X996"/>
    <dbReference type="GeneID" id="28990500"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_133789"/>
    <dbReference type="InParanoid" id="A0A162X996"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="68"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD73345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="610" mass="65815" checksum="C838A7CB94EC70A5" modified="2016-07-06" version="1">MSTEPQVPTHTDRPLSVALSDTATETDVSPASNNVDKLDPVEKVDEISIVETLDRKLAKQIKIQRILIFLGLQLALFLAALDGTIVSTALPRIGSDFNQMAIVSWVATAYILTFDAFQPLFSKFSDIFGRKWIMIFGIVVFLIGSVLCGAAQSMIMLIVSRAIAGIGGAGIFSMVFVIITDLVPLEQRGSYQGLINAVFALSSVFGPLIGGSFTDYVTWRWNFYINLPIGALALAVLMYYLKSDIPKGSMSDKLKRIDYVGTVIVLAFATLFLLAMNFGGQTFPWKSAAVIVPLVLTAILVGLLAVVESKFSKEPLMPPRLFKNRTVLSILITNWFFGITFYSMVYYLPIYFQVVRADSAMWSGIRLIPMQMVVCVGATMAGAFISKTNIYKPLIIVGMALLTLSVGLLSLFDENTGFSKIYGFTVIGGGGLGLLFSSTIIGLQASVEARDIAVVTGLGNFSRILGGALGVAISSAVLNSSLTQDLPGKIPQEYVGLIIASSEYVRHGLPAEHLAATLGVYVKALRLIWYVTTPMCGVGFIASNFIRSRKVGETKVFEKTMSQENASAIQEDGIITGASAEDVKTSQDTVMIEVADAAASSAIESTTCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XB19</accession>
    <name>A0A162XB19_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="12">DHBP synthase</shortName>
            <ecNumber evidence="3 12">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_177499</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3 12"/>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291655.1">
        <property type="nucleotide sequence ID" value="XM_018437894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XB19"/>
    <dbReference type="FunCoup" id="A0A162XB19">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162XB19"/>
    <dbReference type="GeneID" id="28998800"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_177499"/>
    <dbReference type="InParanoid" id="A0A162XB19"/>
    <dbReference type="OrthoDB" id="60371at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000002">
        <property type="entry name" value="3,4-dihydroxy-2-butanone 4-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF18">
        <property type="entry name" value="3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0318">Glutathionylation</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0686">Riboflavin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD73615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="214" mass="23848" checksum="B299A772B659AEDC" modified="2016-07-06" version="1">MQQKYEQYEFHPVADAVKDFANGEFVIVMDNEDRENEGDLIIAAKTVTTEQMAFLIRYSSGYVCVPSTDERLDALELPLMVPRNTELMKTAYTISCDYVHGTTTGISAHDRALTARKLADPTSVATDFSRPGHILPLRAVPGGTFERFGHTEAAVDLCKLAGLPEVACIGELVKEDDPSGSMARRDDCFAFAKKHNIKMITIKDLIEYRRQVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XBI4</accession>
    <name>A0A162XBI4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_145196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291765.1">
        <property type="nucleotide sequence ID" value="XM_018431387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XBI4"/>
    <dbReference type="GeneID" id="28992293"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145196"/>
    <dbReference type="InParanoid" id="A0A162XBI4"/>
    <dbReference type="OrthoDB" id="2236902at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="289" mass="33759" checksum="58252B1DE4E3CF7A" modified="2016-07-06" version="1">MATIKTIKRRILKTTSIFSLQRYLPSQVMMYLARKYYVRMESGILSSNPSLETAYWAMPTLWDQLNREMADASICFTCLLINLKRASLQFIPHLVVISNAGFSSKRYRNTTFNKEENEPFYTHPCQSWAKSTKFYTPESIAIHMDKEPLDKMIALCHVALDICSIDTDKIAKLFADTQSFCDTVECQFQKILNENDSKRQLKYAKDVAHFVRQFERKCLPSTDECAVTPIESICEQQESEDLIFVKEKRRINAGRFNWNNCYSEDMTEGLFQRYSSHTTLRKAFERETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XCG3</accession>
    <name>A0A162XCG3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_168349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291965.1">
        <property type="nucleotide sequence ID" value="XM_018435843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XCG3"/>
    <dbReference type="GeneID" id="28996749"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168349"/>
    <dbReference type="InParanoid" id="A0A162XCG3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="339" mass="37792" checksum="716BDFACE70DEF6C" modified="2016-07-06" version="1">MYNILLDSFQTMVNNRQSIAPAPSPEYTELLRRLTTMEESLKTMDSNIGIVIKGNKDSLEILDSVADASGELLAVIAPTTIPASASVPFTVSSVSSTLDWYTTPSEAFFGISSVAPSVAPSVGPVVLTGANAGELSKQDRTRVLALIQGELKKHNFKSNKPELVAANDSKHSWDVNVDYRLPPNRQLMHDLHAYLAPKVVGTSVRQADISDCIYTNFCGMRRQHFDRRELTYHTFKAEIDVKVGKSCNGLLQKEAMSESESEDDMPGVSSNCAIRTVRPSWRSDEYNHFLVVVDDFMRNCMDFNSHQMLKRSFGRDAVLAVPPRLTSLLPHWAFRDEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XIW5</accession>
    <name>A0A162XIW5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_167503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293225.1">
        <property type="nucleotide sequence ID" value="XM_018435654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XIW5"/>
    <dbReference type="GeneID" id="28996560"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167503"/>
    <dbReference type="InParanoid" id="A0A162XIW5"/>
    <dbReference type="OrthoDB" id="2289193at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="32520" checksum="4242A061CFE104CF" modified="2016-07-06" version="1">MSTYFFYENGQGKIYDEQGNDAMEWSEEAQPSEQEQMRGELDENMNEVYLRVNEEDNNVTKKSYKVYSPVQKVLFLYYLQVKLFKAAKAARFSGVSERTGQQWAKRIRDEPEWNIFEKQTNKDKRKTGQLQEEHKEFIIDLFDKNPQTRVKDVVVSLERSFANFSLKETSVRNFMTNECNLSFKRATLQTKERNSGKTLQKRFEWLRVTEKPKQRKVDGVGRKRKQTSNQKRREGTKTESIYEKSDEKLMIQAIYFRQATTSIITEYCSTSLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XM27</accession>
    <name>A0A162XM27_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_143899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293695.1">
        <property type="nucleotide sequence ID" value="XM_018431092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XM27"/>
    <dbReference type="GeneID" id="28991998"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143899"/>
    <dbReference type="InParanoid" id="A0A162XM27"/>
    <dbReference type="OrthoDB" id="2211252at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="390" mass="44334" checksum="269B6ABA6D5CD8D1" modified="2016-07-06" version="1">MNIQFMFENKKGSVVDKYGRSEPMDYIVDEEQFRLETLISHTQYNPSALKSEKEIGTMQVEKEVKCLSAATAAKQLGTHVRTAQKWAKQYETDPDWIFEKRRKTGRLCILHEEHKNAIIECIDGNPSVVLDELMKKLKQTFTELKVSKTTFFDFVKQHCNLSLKKARLQPMGQHVVHHTLPAIYANHSPSTLIRPISLLFPGPASSCPSPLRSLLQASAHLRTSSSGSFLTLKTNDVLAEHGRLRIRRYQKAISAENMQYTLWLHHLLESQAQLTDTSMPDPLDLSPLTKDIIIGKTSLYKASSSDFRSHIQPHSLTTNLSRAAWIHCHFFDDDICPICLSAIDTPDHFLINCPKKRLVWSIILSQPLQSMPSGELTERLSWTNSPSFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZI56</accession>
    <name>A0A162ZI56_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate esterase family 4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_101648</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD66931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284971.1">
        <property type="nucleotide sequence ID" value="XM_018427645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZI56"/>
    <dbReference type="STRING" id="763407.A0A162ZI56"/>
    <dbReference type="GeneID" id="28988551"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_101648"/>
    <dbReference type="InParanoid" id="A0A162ZI56"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10917">
        <property type="entry name" value="CE4_NodB_like_6s_7s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF133">
        <property type="entry name" value="CHITIN DEACETYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD66931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="130" mass="14935" checksum="4075912313A27C5B" modified="2016-07-06" version="1" fragment="single">CPSAHHWALTFDDGPSNYTSELLDILDEYRIKATFCVLGSNVKRYPQVLQRIFQSGHQIASHTYSHPHLMSLTNEEIIYEIKATEEAIRDAIGIKPKYIRPPFGEADDRVKGLLRTMGYRVLMWNVDPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZPU2</accession>
    <name>A0A162ZPU2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_173307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286341.1">
        <property type="nucleotide sequence ID" value="XM_018436998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZPU2"/>
    <dbReference type="GeneID" id="28997904"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_173307"/>
    <dbReference type="InParanoid" id="A0A162ZPU2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="41389" checksum="70429C6AED935FC7" modified="2016-07-06" version="1">MPSNSSRKTDRKGKGKASASISTSANRVLAGCVGPREIAPSFSSATIQDQQYAEIVEMFNKVNNNINGVKDDIAAVNSNMAAFKNRMGVVVDTSGKTHTAFADFATAYANNQTRMASLGPSLMPSYVPQTSLSDAEVSVIISEIFAEKLWDWKFESDDPALVAENESKKKWNLNEKINHRDNVAVINYLKSYISTQTRLAGTHPRVISDKIKNRYKHSHRTFHESSEQKAKKNSKGRANSRTLQMSIRRKSTYMDNWVAIDAAMGYKTGNPVEKAYLKLFQKDAMSDGESDIEIVDNLPRRCLHVARPTWRSEEFNRLLTMVDDIDRTHHVLNAGVGTKPRMNRYPATLLPCSVPATLSQSLPRWAINDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZSG1</accession>
    <name>A0A162ZSG1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_19333</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286811.1">
        <property type="nucleotide sequence ID" value="XM_018439701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZSG1"/>
    <dbReference type="STRING" id="763407.A0A162ZSG1"/>
    <dbReference type="GeneID" id="29000607"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_19333"/>
    <dbReference type="InParanoid" id="A0A162ZSG1"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="119"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="306"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="486"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD68771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="513" mass="57183" checksum="82A9753D9789A979" modified="2016-07-06" version="1" fragment="single">DSDEEVYATAAAIDAQNNYDSDENVQVIRKEIEPLARVSHSSITYPPIEKCFYEEHPDIARLTQEQVQRLRQELQLHVSGNRPAKPCVSFAHFGFDEDLIASVLKAGYTEPSAIQKQAIPVTLEGRDIIGIAKTGSGKTAAFVLPMLVHIMDQEELAKGDGPIGLILAPTRELAVQIYSEAKRFAKAYGLKVAAVYGGASKMDQFKELRSGTVEIMVATPGRLIDMIKMKATNLRRVSYLVLDEADRMFDLGFEPQVRSICDNVRPDRQTLLFSATFQKRVEQLARQVTSDPIRISVGNAGQANEDITQVAIILEDDMYKWDWLMRYLAGFCVEGSVIIFVSRKGAVDILASNLQEAGFQCGALHGDLIQYDREKVLKDFRANKFNILVATDVAARGLDIKTVKTVVNYDLARDMDSHVHRVGRTGRAGEKGTAYTILTKKEDRFAGELVRHFEQSGQLVSQELQALAMQNGRFRGSREFKESRGRGRGRGKGRGQGKHSVLHIITMQLYLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZT73</accession>
    <name>A0A162ZT73_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_66981</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286911.1">
        <property type="nucleotide sequence ID" value="XM_018441719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZT73"/>
    <dbReference type="STRING" id="763407.A0A162ZT73"/>
    <dbReference type="GeneID" id="29002625"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_66981"/>
    <dbReference type="InParanoid" id="A0A162ZT73"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF99">
        <property type="entry name" value="RASGEF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="4">
        <location>
            <begin position="37"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="3">
        <location>
            <begin position="265"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD68871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="61702" checksum="F45DB5B9B614F85D" modified="2016-07-06" version="1">MEHVIDGRACKKTHREGNTLCISENGKDVLVMEMVNGKLQVVAGTNEKLFIKLADEASQVIIDLIDLDYVDTYLMNHACFTTSAELLENLIARFHIEALAGETEYFDKWQRCIQLKVLNVVSRWIKIQYQDFNNSRQLLRRLESFVNNSIKQAGFSAEAKTLREALDIEMAKCTRSRHSLVALTSYSLVGSGQTTPPSTPCLSSFSIASHHQSHSQSRRPSLAPSLLSFVSSVTPPDSPISSSQQLQSQSQSQSYNAPPLLLLYEAKEIAKYLTLADFYTFKCITAHDYLNGQWKNQSAEHKGPRNYIGTMTRRANMLTHWVAHELCVLKTPKQRKTGLRKMIEIAKLCLEWNNFHTSMILTMGLTSRAVQKLDDWQALPSRDTHVFHGLQKYLDVSSNMATYRQAFNKVKSPAIPFLPLVLKDLTFFLDGNPTHTPPPPPPQPSQQVVVMQSETMTTCSSENLINFAKFQSLARFMNRLLSHTSENYSFAGELEHFPFFFGIKFYDEEKHALDGVAEVVEQRIEGVADCYHDSQCVPCCIDKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AJH6</accession>
    <name>A0A163AJH6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_186981</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291951.1">
        <property type="nucleotide sequence ID" value="XM_018439310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AJH6"/>
    <dbReference type="FunCoup" id="A0A163AJH6">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163AJH6"/>
    <dbReference type="GeneID" id="29000216"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_186981"/>
    <dbReference type="InParanoid" id="A0A163AJH6"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000019">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="12">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="13">
        <location>
            <begin position="246"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD73911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="449" mass="49876" checksum="30D305305E2CB0AD" modified="2016-07-06" version="1">MREIISIHVGQAGVQIGNACWELYCLEHGIQPDGNIPKELDTGDNSFDTFFSETSGGKHVPRTVMVDLEPTVVDEVRTGAYRQLFHPEQLITGKEDAANNYARGHYTVGKELVDSVLDRIRKLADNCTGLQGFLVFHSFGGGTGSGFGALLLERLSVDYGKKSKLEFSVYPAPQVSTAVVEPYNSILTTHTTLEHSDVSFMVDNEAIYDICRRNLDIERPTYSNLNRLIAQVVSSITASLRFDGSLNVDLNEFQTNLVPYPRIHFPLVTYAPIISAAKAYHEQLSVQEITSACFEPNNQMVKCDPRHGKYMACCLLYRGDVVPKDTNAAITNIKTKRTIQFVDWCPTGFKVGINNRAPAAVPGGDLATVQRALCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGSDSLGDSEIEEAEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AJJ8</accession>
    <name>A0A163AJJ8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_181419</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291961.1">
        <property type="nucleotide sequence ID" value="XM_018438465.1"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163AJJ8"/>
    <dbReference type="GeneID" id="28999371"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_181419"/>
    <dbReference type="InParanoid" id="A0A163AJJ8"/>
    <dbReference type="OrthoDB" id="28245at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF142">
        <property type="entry name" value="NEUROFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="1226"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="514"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="867"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD73921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="2593" mass="292719" checksum="151DBA7FBC31A36D" modified="2016-07-06" version="1">MSPDTKLILSLVNRISVKLPSNSGKSLDSLENDILVQQTQSSWEINMHKPIFLVTTLIELSRFRLSTIASTIVSVLEVVSKSVAATPGDDYIPNDILQSQLFLLRMLSACMQHHWEFIRTNKDSPADLPTLQDPPPLEDTLAKYMISIMSRFMHQMTVMEERDHGSATNITRTAYYSISGLTSLPTDIVVDIYKAASRVVFYLSASNWYIMHSKLRARILYLTTTSDEAPDTSDIRLLECCALNSKRLSMMFEELHPTFTRLKKSAQLAIAVILRRAIWGWIETYPSEFINLCRSKKRLDGRPDILFDICNSLADTTRKKAILWPLQTILLALCPDLMIASSASEGRGFLAKKTLFFNTLKKAIKGGRTAELAAICYVDICKAVNYVSKEETSSFKHLVPEIEKELKEKLFDIDHPLMADNLMNSVGIIIDHRYLLADTLVAMFRLNSRKAMQTHFPTCLDERAPTLFRLSLVKACLAIAMQENRLPWNPSISSLYSSLCDPLKRLFLETTRADPTRSETTSLSNRRPPTVGDKKVKKDKDSTHERLEMMLDMLRLYQADPNMAIRGNAEDKTEQNAAVMVAVTMCLRELNQAVRDAAAETLFKLHAPHYILEWGVPERFMESFWSISSQVIHTLAKQMIDTREREDSLKKLLDLLKKLLICRNEFLRIHQDIAMQGADVRDRLHASIALEVSLLVLLCSADTDICSAAIACFGHICIEAHITDGMDDPQQTSLTVAENLPIYIELTSNTGIVTGRKSQQKQIRRLLRMMSHYAPGNISAWEEAWKRWKNLTPSILRPSEEPKEDMSEVTRKTTQAWHDKLRNTRQQNTISSRSENLEDDRSSEWQNYAGFLAALGGICLMGGALPSSAQSPRHHEADPRRSSTQSESAAMADRFVMDMVDLLLCDNVILREWVKEILGTDLSPALYPMLFRHLETVLAKCFGPDGDPTCSPRYTLFVEQAISVLKFVLDRMEESADTLFTVDFSQLISQYAKYLNKLGSSQAALKIKIKFCQLCEVLMAKKEKVTLRQEFKLRNKLLEIIVEWTSDFSLKVDVNSHYSSFEQGEKLHRDLDLACLKTIVNLLHQLPLQPSEPVHETGASQVKSRMFYKYFTFFLKLLNRCRISENKDNATYLGPLKEYTILAMSNLLSANVDAGLKYSLSMGYHEDTRMRTAFMQVLTNILNQGTEFETLAETVMTDRYEKIIDMLVEPDLHIAMSLCNVCPATDIDDASNALLACFSSRGNAMTLLKAVIDKEVQNTENHTELFRRTSIATRLLSVFAKTYGAEYVQSVLQPVFHVLLDTPREERSFELDPSKVGPGEDVYRNRENVISVTQLFLNAICASSNEAPPSFRELCHHILVSVRERFPEAKNTAVGAFIFLRFFCPAIVSPESEGLIKGSLSISREMRRGHLIATKVIQNLANNMLFGTKETYMIVLNDFVTSNIYNVTKFLREISDISPGEEFEADIRQMEDKDYALLHRVLADNMERMTRDVATRRQRLFADTDTWAVWKRMFDKFSNLLAQLGRPPEIQKQEFSGLRSYTFAAANQVYAEFMRRNSHRSVDAIATKNIFYEGGTSKVGRPVLYIIARNISNDSIDFELFIYYMLQKKKKQVLERTANKAIEVVFDLTLFGHANEIPNQWISQILQLLPSDVCDNVATFHIYNPNSHLRKYIKKLLHPITHKVSKRISFAVTLAELYESIHPSEVRLPKSTMTLDTEPSAVFYPVNHISQFKTNVPVTVKVGAEYVQIMTGRKQELLYGVSTVTNDVYRISEIEDIVLSPGRGAEVANEFSFKYDKGRLIVILSTIKREAIVSTIRHSKRCYEMSKPSNITERTIRPSDVPGRLLNMALLNIGSEDPNLRLASYNLLYALSKTFHFDVGKQLLDARDLCLPANSTAFIVGISEKLAISEPNLTLEFLNECFVGFNKSNEPMRYLCLDYMIAWLPNLAIFSHGSSDDNNSVKTKEVLRLLIDLTVTRADMYKLLQAKVWKTIGKVDDVLNLVLDTFVQFSSDHGVGSPQAESMADTFVTLSNVAVRGKVISRLRKVLQRTSFQPMRSLSEHYTWNEIAVLVRFILMLSFNNRGPVKSYIPEMFHIVSLVVSTGPILVRASVHGLVVNMIQSLCTAMPLPESNVKKLQLLLAEISDTKFRLLFGLAKPHLNPFTINDETLSDSSDRIQLGSLETIVTTLLDVLQYAAPSADMANVWRARWMSLVASTAFQFNPAIQPRALVTLGCIAREEVDDELLYQLLAALRGALAIFNETDPSLVLSIIMCLKNIVESLPPDSRYLSSLFWVAVSLVQINNGPTFSMAVELLLALLRALDANEYFSGDVMVDVLLAARVPMLDVARRLDQLCGVDFESHFSFAMSCVFMRGLQFANAKDTIYHALTVFLGVENKHSSLETDEIDANILGYFAGLLPMAIKNESLRDVLKLAGMGDLDLEVSDSNMGTTYHGIFDKMDIPDNTTALLLVSMLSTQLNMADNESERLFLYGLLAEAAVSMPDVFVSVYDTLLPKMNQILLNNNTQPIIESIKTILIIACSDPVFGDMKNRRTQKTLLEEIGFSSLGEANFGVSTADVLQNAMLASELIERIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AN92</accession>
    <name>A0A163AN92_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carotenoid oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_76627</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292691.1">
        <property type="nucleotide sequence ID" value="XM_018443177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AN92"/>
    <dbReference type="STRING" id="763407.A0A163AN92"/>
    <dbReference type="GeneID" id="29004083"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_76627"/>
    <dbReference type="InParanoid" id="A0A163AN92"/>
    <dbReference type="OrthoDB" id="407010at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF24">
        <property type="entry name" value="CAROTENOID ISOMEROOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="681"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD74651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="688" mass="76857" checksum="8F5BA7FFB57DA2B5" modified="2016-07-06" version="1">MAEQMNPTNISAMAVDDQPFNGQHEEHELSHSTQLDSTTRITNAMEDLSVDYPEDSQDNSFDPSLEITSAYDNDDWEQQERSLLDDQGQPALSRSSSPFPPSTVKRNTVNLEGDTTHAKGFFNTGDISDIKELKVEGQLPEWLTGEHFTVGPGTYEVKYTRKIEIDGFLQSATGNFSFGHWFDSLPLVNRLDYNGSRNTITYRNKLTCRRMIEKLRDHHGYAPCHPAGLFKTDSNQTVLVKFIKSSTKATKPDGEPCGARIMHSIPGIDGRLFCQNMANHIQELDPFDLKPTRVLTTQEINPAFKGYNSCPNPQVDARTGEYINFTMDIGYSSTSYHFFSLSAQDPKGHIIASIHNAPTGYVNSFALTEKYIVLFVFPLLANSGAVKYAWNESIMDSFTFCPTEPTLIYVISRSENKHVATYRTDPCFAFHHVNAFDDDNNNVFVDIVCYPDDTIANQLTLENLRNPETMKPAQLAKSEVRRYRLNNVLDASKVFNANNTIIPTTSSISSRVSSLWGYMRGAQSVPGATNDEESRAFATGSSGWHSWIPLAAYDKRLEHPIELPQVNPLYKARPYTFIYGIGFSPNTVNENGKIWDSIVKTNVNTNAVVASWHEEFCFPSEAIFIPSPKGGENAVEDDGVLVSIVMNAALATSFVLVLDAVTLEELARADLEFLVPLSFAHGSYKLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ATC3</accession>
    <name>A0A163ATC3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_166879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293691.1">
        <property type="nucleotide sequence ID" value="XM_018435511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ATC3"/>
    <dbReference type="STRING" id="763407.A0A163ATC3"/>
    <dbReference type="GeneID" id="28996417"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166879"/>
    <dbReference type="InParanoid" id="A0A163ATC3"/>
    <dbReference type="OrthoDB" id="436519at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029827">
        <property type="entry name" value="JDP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44500">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44500:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="13"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD75651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="162" mass="18926" checksum="E327B83596BDEC0B" modified="2016-07-06" version="1">MQPFFDAHSKEVDFYKVLGCVSTSTNEQIRVEYRRLALMYHPDKLSIHDSKDAEDIAYKYKEIKAAYDVVGDPVKRAIYDRWQQSELQIPFSDFAQLNSHGQVVHWQTLPAKRTLTTKENLGAQDVDERRPFVGETSSSIQINPVSFWAKDDIYSKFRDYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AUE7</accession>
    <name>A0A163AUE7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_75904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293941.1">
        <property type="nucleotide sequence ID" value="XM_018443104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AUE7"/>
    <dbReference type="GeneID" id="29004010"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_75904"/>
    <dbReference type="InParanoid" id="A0A163AUE7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="83" mass="9181" checksum="69B38C79B51086F8" modified="2016-07-06" version="1" fragment="single">MEKVRQALAQQVSKEAEDRRATELAAENPKSIDVHMRDIYGTAIDSNYGPTNSATQLCTDRTHPFKEDAEMQISGEGSSSHDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AV06</accession>
    <name>A0A163AV06_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_158189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294041.1">
        <property type="nucleotide sequence ID" value="XM_018433751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AV06"/>
    <dbReference type="GeneID" id="28994657"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_158189"/>
    <dbReference type="InParanoid" id="A0A163AV06"/>
    <dbReference type="OrthoDB" id="2404451at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="124" mass="14220" checksum="3F0798EB9D975A74" modified="2016-07-06" version="1">MFTCPYRNNCNVIVHSWLVGTVQFYFQHVDFYGFPHFLAFVEVMKEHDTAGHDSSVPIVKQRSQSTRTLGHQTQPTYAVISVNDICHQVGLVQYPPNGNQFYVIAPYYIFNNNMCITKGNLSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B9I8</accession>
    <name>A0A163B9I8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_141056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD79001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297041.1">
        <property type="nucleotide sequence ID" value="XM_018430517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B9I8"/>
    <dbReference type="STRING" id="763407.A0A163B9I8"/>
    <dbReference type="GeneID" id="28991423"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141056"/>
    <dbReference type="InParanoid" id="A0A163B9I8"/>
    <dbReference type="OrthoDB" id="2379842at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22744">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="95"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD79001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="532" mass="60836" checksum="E8B4A1BC6EB0B9E5" modified="2016-07-06" version="1">MSCKEKWAGYLTNKLKHFDCVTTQRVESGHHALKRSILALQSLDSLFEQICLYLLQFEGDYQDRTLDEKLVTDAKILADERLCGLVHSVSRMALFTIRAELLEEIIIGEACYCRVKTMFGLPCRHTLPRNRALTLADIPERWVLSSALPFYNKEVEKLEREQQICNLMAKVNDLINNAGNLKDHREVAFPLSSEVKAPGRPKHVKRKTALPKDFVRHKHRHLLVQKNKNDIRSILKEGLKEVMKEFLEEEPLKKIIKEIKKETQFAEKQEPLKEAKTTNFAKKQEPLEEAKKYFSGIKRPKHLQDDYWYNLPSPKKQNKNVHDFALPAQIDQAAISLTFNPKSNGWCGFRVFAHLKEGGEDQFPLVKKKMLATMATHGKLYKHNFGIDVAKVTEVIAFGSEIDPALGENIPSCPSSMWFSAPDCAQIIADTYNKPVCVYSDDRSVLPVTFLPLHDRKPLKRKPLPMVLHHVHGCHWTTIKVKPHVHRSWPEFPKNKSYLLPSTTTTTITTTATNSPTNSPVNSSNIIDLTHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BG97</accession>
    <name>A0A163BG97_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_138941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299431.1">
        <property type="nucleotide sequence ID" value="XM_018430114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BG97"/>
    <dbReference type="GeneID" id="28991020"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138941"/>
    <dbReference type="InParanoid" id="A0A163BG97"/>
    <dbReference type="OrthoDB" id="2221454at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD81391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="615" mass="74299" checksum="17945F6262478ACC" modified="2016-07-06" version="1">MVSILPPNILSYIATHINKKDQTSCSLVCKRWTEPFLNAYWAKLEIDENKLSTMFATSTLNEVYRKNVHRVWALDLKRINIRHIGYVTQLQQSFPGIKYLFCDEENHEDESDNWMIRSIDWISWRFLTHLSIKLTSKHSGLEDIFMNLSVSRSLAHFTLNSENNVEETNTMLWTQFESLHRHMRQLEYLDINYPLSSISKYDLEMIKTIEPAHKITKITFLDVRIDGSWLYYFALKYPNLLSLNMKPCKARRPLVQETYINKYQGQLILLKTLNQFFPYLKMVQTPTHTCNRWPLYIFYMTLNYFNIKLERVVFDTHVYKSLLMDNLTKCIKQVSESVKIMWVTITDYLNAKPRSRIIFNLCPKLVELHILEHRRIEMEHLLDQCPVLRSLYIENSTTYLINPSRHITIPHSLQKLEFINVSVPIHLFNYISLRCKQLKYLKLKSVTFLIPEWDINGKALFDMHMSQLKTFIIYNYSYCFQHVRHYAIEQLENTDGNSLQHQESQEISFRTNWYHLCLDKTNRKERLLAWELGRRDIEFSQRYYKDFERRKKREKKRKDMIRHCGYAPKRFWKRDLQYGVMIFRFKSVKEYFLDEKREIDKDKHIQSHQLNERKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163CVV5</accession>
    <name>A0A163CVV5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_119629</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441007">
        <property type="protein sequence ID" value="OAD65970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284010.1">
        <property type="nucleotide sequence ID" value="XM_018428698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163CVV5"/>
    <dbReference type="FunCoup" id="A0A163CVV5">
        <property type="interactions" value="490"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163CVV5"/>
    <dbReference type="GeneID" id="28989604"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_119629"/>
    <dbReference type="InParanoid" id="A0A163CVV5"/>
    <dbReference type="OrthoDB" id="10261918at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="8">
        <location>
            <begin position="4"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD65970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="260" mass="30437" checksum="C35B114D0A017A1D" modified="2016-07-06" version="1" fragment="single">TFNISRQEVVRRLRAKGQPIRLFAETDKQCRIRLRALELMEERSEDQGQRNDFMRQLGEMEEGMKLDVLRQKDGIVDDKSLKKPKKPDLVVEPITLGLLQADRDRLNMQIYAYLAYTQQEWADFMEQRPEEEKRSTQGKRAAVLQKQTAEYIKPLLKQLKKRSLEPDILARVAEITHHMQNRRYRDAQDSYLQLSIGNAPWPIGVTMVGIHERSAREKIFSSQVAHVLNDETSRKWIQSVKRLMTFAQSKYPPDTLSQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163CWH5</accession>
    <name>A0A163CWH5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Helix-loop-helix DNA-binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_175407</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441005">
        <property type="protein sequence ID" value="OAD66110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284150.1">
        <property type="nucleotide sequence ID" value="XM_018437482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163CWH5"/>
    <dbReference type="STRING" id="763407.A0A163CWH5"/>
    <dbReference type="GeneID" id="28998388"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175407"/>
    <dbReference type="InParanoid" id="A0A163CWH5"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="352"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="238"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="365"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD66110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="440" mass="51448" checksum="CD1227B2881D9BE7" modified="2016-07-06" version="1">MDVTTREPEVPKTRVAHMQQMHFKDPLIKINQHLLQNNIFLSQSTPPQPQSQPLSLSLSLPISLPQPQEQEQEQEQEQEQEPEQEQEQALKQEQEQEQNQEQDPNHSHSHQDLSYTDLVSEKFGPINHSQLEQYYDNSQLIMKRSTALQSNNSINTAAVYRQHTNIINNHNNHNHSNSIQQHHQQINNNNNLHHHHNHHMHHINHSQEDPNTQEPTNDFLFYPSAAIHLDQRYRPFAGGSPANIGYGPMPHNHHNHHNHQQHHQHHHHHHHQQQQQQQHTFGDSVPVAEDGAVVDATSFAISPSLKTNSKKYPHERTRRQSKPASPQEAIENYDDMFAAQANLQAIMDKRRRRRESHNAVERRRRDNINDRIQELGTLLPDLEEDGINRLNKGTILRKSVDQIKQLQRDVNQCQQRVHELETLLKQVSRQRTPSARLQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163CZB8</accession>
    <name>A0A163CZB8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_73301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285650.1">
        <property type="nucleotide sequence ID" value="XM_018442825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163CZB8"/>
    <dbReference type="STRING" id="763407.A0A163CZB8"/>
    <dbReference type="GeneID" id="29003731"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73301"/>
    <dbReference type="InParanoid" id="A0A163CZB8"/>
    <dbReference type="OrthoDB" id="2206543at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD67610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="506" mass="54998" checksum="83ADC8F11561E4D7" modified="2016-07-06" version="1">MKRCPIEEPTKENQKAEICNMYLNSRGAKLSASPTTSQLPVPLLSSPALFFFSEGGSGVLPSTSHFFVPVSDLSFSALPAPGSHEIFFQAPPTMIGSQKQVINSTGRPTPTALILSGLKADFKKLHNVLSCSRCQTTGKIVSNGSTSRTGSPQFKCKCGATFTASSMQSLINAVQHKIPEVRSASEPVVSPSVSILGHSISMADIHEIESDVAPVLPTVMPTLQDIWDRFQVYDERLSALEAVQKENIELRKALATANATIARLTKENVDFSVGAAASKYATIAASVPVVSQADFPSLPASPTHHSTEPTKTFVSKTPRKRAPTARAIAAVVRGMTIKENADQGFQIVYVPNAIRLPISTQRQRLRKLKIDNARVLDLHYPDRKVMGMLVHNEYAPELKTILASYGVTTLDNFDPLDPVHLRDPALASLSLDDRATKAIHVHNDCMLRAIEFIRAPVKFAVARSFCSQGWISDDQLAEIVPPRPTKKDLDISIHTASITIPSFSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DBS7</accession>
    <name>A0A163DBS7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial cardiolipin hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_159629</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the phospholipase D family. MitoPLD/Zucchini subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288290.1">
        <property type="nucleotide sequence ID" value="XM_018434024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DBS7"/>
    <dbReference type="STRING" id="763407.A0A163DBS7"/>
    <dbReference type="GeneID" id="28994930"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159629"/>
    <dbReference type="InParanoid" id="A0A163DBS7"/>
    <dbReference type="OrthoDB" id="5205528at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016891">
        <property type="term" value="F:RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09171">
        <property type="entry name" value="PLDc_vPLD6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051406">
        <property type="entry name" value="PLD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43856">
        <property type="entry name" value="CARDIOLIPIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43856:SF1">
        <property type="entry name" value="MITOCHONDRIAL CARDIOLIPIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="111"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD70250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="423" mass="47100" checksum="A459E54F7A97A827" modified="2016-07-06" version="1">MNHLFELLCCPSGSSLTEAEIKKANYQELIEKTMASSNVLMKDQNLKDQASARLKTVLTSKSHSPTNTIKTVQQMFEAALKGKSGRERHLIEWLQICVSSAIHMAFLIDEPEKQQPSSDRSIPTPQKKPSGTKEKKKAPRATRKKRNSDDDAFVVPDTEDDDPPYRGSVSSDDEYLPSDDFPEGTGLIKQKGRPKRGSNTSAKKTAEDLKNDDDQQVPDVKPVPAKKAGRKKRSDINDQVVPTDGVMVPAIESGAGAGEVTRYFTSLTQSAGSNVLSKGYFAKAYFFPSKESFNAFISVINSARDCIDICVFSLTDDDVADALIAAKKRKVNIRIITDNQQAAGKGADAERLQRDHGIPYKTDNTTGYMHNKFAIVDHSTLINGSFNWSKGARFKNRENIMITNIPYCIQEFQRQFESLWEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DIA8</accession>
    <name>A0A163DIA8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_147914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289460.1">
        <property type="nucleotide sequence ID" value="XM_018431974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DIA8"/>
    <dbReference type="GeneID" id="28992880"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_147914"/>
    <dbReference type="InParanoid" id="A0A163DIA8"/>
    <dbReference type="OrthoDB" id="2095648at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="175" mass="19575" checksum="C6AD9E0DB6430ACD" modified="2016-07-06" version="1">MPFDDFVDNDVPEGENNAADLRFLRYAAKDLDIELGDLIMAISFLPCLRKLSCLTTGPVFQRAYTLEDIETIHSYLPHLEHLSLTISIDPLSERDIVEIQKIKPAEKMKSFAIATDCGKGERLVDEPEKPTTPPVILPGALSSLRNVTISSTPKEETSPYSLRKLLAKHDLKLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DTX1</accession>
    <name>A0A163DTX1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CYP5314 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_88695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291420.1">
        <property type="nucleotide sequence ID" value="XM_018443697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DTX1"/>
    <dbReference type="STRING" id="763407.A0A163DTX1"/>
    <dbReference type="GeneID" id="29004602"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_88695"/>
    <dbReference type="InParanoid" id="A0A163DTX1"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD73380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="408" mass="46865" checksum="3E8D9E47BADDADD9" modified="2016-07-06" version="1" fragment="single">HIKMAEYSKELGPIYQMSFGGRDYIVLNSPEVIKGVLETNGSKNSDRVPSTVVLLMSDNGLMWAWGADNSYLRKSRRLFHNGFINKTNWEKNFPELYNNQVGRILRKIRDHGTADEGYSLMDVCYLYTINVSMSVLFNRDYESCDDPDFLEMNAVAHDFSDLGVALQIECPKILEFAISPFMNNAKRLQNKFRSVFSKYIKELREKRAKGIIVKCLISDILDVQEKEQLTEPELDNFAAASMVGATDTTALSLANLLVTLANYPEVQLKVQKELDTVVGIERHPTEQDLINLPYTKAVITECLRFCPPVWISLPHMSRERQVYNGYEIPANTGILQNIYATNMSPELFDKPEEFNPDRYYKEELLKPNQRDHWSFGNGRRTCPGNIFAEKSLQYFTARILWAYTLTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163E019</accession>
    <name>A0A163E019_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_144934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292530.1">
        <property type="nucleotide sequence ID" value="XM_018431322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163E019"/>
    <dbReference type="GeneID" id="28992228"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144934"/>
    <dbReference type="InParanoid" id="A0A163E019"/>
    <dbReference type="OrthoDB" id="10580726at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="234" mass="26531" checksum="4EF35FE3AFD91B82" modified="2016-07-06" version="1">MTSACYKDANVKTYNRSYYYEIYIQASILEYGHNRPTTDDDNISNTLLLVETIISIKPTLLKHDSQSSYENTNPPVVHKIYEKKGPYIIRLTVEMSSNLKSPSERRFRVPSRSIPYSPHRESEPLGDPRDSRLKPRLTPRSTSKPEPSSVGGPSSMTDPLNTMPLFDSVSQNVSPDGSVQEKGNEDQGILTGTEEYPTASAKTAFIQKITDIFEDNFLSKERSDYFSRKRRHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EGL9</accession>
    <name>A0A163EGL9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_107845</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296570.1">
        <property type="nucleotide sequence ID" value="XM_018428015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EGL9"/>
    <dbReference type="STRING" id="763407.A0A163EGL9"/>
    <dbReference type="GeneID" id="28988921"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_107845"/>
    <dbReference type="InParanoid" id="A0A163EGL9"/>
    <dbReference type="OrthoDB" id="5580488at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22147">
        <property type="entry name" value="F-box_SpPof1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051075">
        <property type="entry name" value="SCF_subunit_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872">
        <property type="entry name" value="UBIQUITIN LIGASE SPECIFICITY FACTOR/HREP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872:SF9">
        <property type="entry name" value="UBIQUITIN-BINDING SDF UBIQUITIN LIGASE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="58"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="178"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="220"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="260"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="299"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="417"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="457"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD78530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="492" mass="55697" checksum="6F9187741E5D08D7" modified="2016-07-06" version="1" fragment="single">QELEQLPLRDQTPINNLWSVFDAAPAQQRILILKGLLSTCCTSQLSYLASALQPLLRIDFTVILPIEISIKIFTYLDAQSLCKAAQVNKRWREIADDDILWHRMCEQHIDRKCTKCGWRLALLQKPKLIRSPEKRVREDSTEDLPNKRTDRKLWKDIYSERLVVERHWRKNKYVHRVLKGHMDGVMCLQFCEYQNMLITGSYDKTIIVWNLETGALLETLKGHTRCVRTLQFDDTKLVTGSMDNTLRIWNYRTGQCIRTLEGHTNGVVHLHFDARILASGSADATIKIWNFQTGKCYTLTGHTHLVNHVKIYNNSTSLVSTSDDTTIRIWDLEKRTCTRVLQGHLAPVQVAVPSMPGLIHRFEDYTANLQIQKTHTGTSFQAPSTSSTTSVPVIISGSLDTSIKIWSIETGNCLGTLLGHAHGVWTLAYDKQRLVSGSHDGIIKIWDIEKGNPMYSLQGHTSAVTAIALGDAKVVSASDNGEIHIWDYGAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EPR0</accession>
    <name>A0A163EPR0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_161331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298730.1">
        <property type="nucleotide sequence ID" value="XM_018434380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EPR0"/>
    <dbReference type="STRING" id="763407.A0A163EPR0"/>
    <dbReference type="GeneID" id="28995286"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161331"/>
    <dbReference type="InParanoid" id="A0A163EPR0"/>
    <dbReference type="OrthoDB" id="5421at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000661">
        <property type="entry name" value="calmodulin-interacting protein 111 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF51">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="125"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="411"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD80690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="648" mass="72155" checksum="F170C660294CB190" modified="2016-07-06" version="1">MDSELGTKVLISISSTDQFVPGTHGMPDFQEMCKRRLGSRSVTIGDCISWSIGGRPIKALIKDITGTQDGTIKIDRNETEIQVEIATHKPTDPIEKIDEEAEALIGIIRSSFENSDAYRILGIPVAKSILLHGVAGVGKTRLTRHASQVLQSSLFDISIHEVLALSEEFENKEFKLYNPIHLIIEQAKIRTPSIVIIRDLNALVNASEDSTKVLNIISQEIKGISSNEQVCVVGMARELRLLPEALQKTDIFQQHFTLSIPSMPQRKLIAENILQDFELDSQLSKVEAVNYYATQISMRTSGYVALDLKRLCKRALLKSLRRNRLESDDLAGELAQLSLVPESKKRPVEWSDFEYALSTYRPSQQIEVEASLPKRDWKEIGGCEKIKQKITQATLLPLLQPEIFTRLGVKPPSGLLLYGPSGCGKTAMVQALASESMMNVISIKGPEIFSKYLGETESKVRKLFATAKRIAPCIMFIDEMDAIGTRRGWDTSDSGGGVNERVLSTLLNEMDGVEGRQGVIVIGCTNRPDQIDDAILRPGRLDQLIYVGLPTMEERLDIVMILSKKMVVSPTVDLQSLAQQTEYCNGADLENMFRGAGILALRQDLNANAIEDKHLQQILETVCKRAKHQVLEQDSLAIYEKFRNDHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EQD8</accession>
    <name>A0A163EQD8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_138380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298870.1">
        <property type="nucleotide sequence ID" value="XM_018429985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EQD8"/>
    <dbReference type="GeneID" id="28990891"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138380"/>
    <dbReference type="InParanoid" id="A0A163EQD8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="158" mass="18064" checksum="6DF4DBCA6B369D86" modified="2016-07-06" version="1">MPIHKQPGNEINRVETASEVDDSAHVSLDIVTTPTSIEEQEEEKTTRHCYKTAVPPVFNASNQPERDRENEIKSRIAYLRDIRPMPYTDYEGKEHSLLAAPKLCPKKERQPLKMIHSKFLPLPSAIPFWINSPTGPIFYSGARSFYLTWPCSGYSVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JH90</accession>
    <name>A0A167JH90_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_175717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441007">
        <property type="protein sequence ID" value="OAD65978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284018.1">
        <property type="nucleotide sequence ID" value="XM_018437554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JH90"/>
    <dbReference type="STRING" id="763407.A0A167JH90"/>
    <dbReference type="GeneID" id="28998460"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175717"/>
    <dbReference type="InParanoid" id="A0A167JH90"/>
    <dbReference type="OrthoDB" id="2406983at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="170" mass="19091" checksum="7D52BCC076379A76" modified="2016-07-06" version="1">MNYLVMDRCTETAAHDLAEDQEQQDPGFSSLSLDTNPITNDLMSASPALDALYNIPTMAIPTAGIIVEVNHLLFNRTSYFQLAPDATIEPLIAWLRLSFTDHSISGMVLQYKGFDGLWKCLLNRDDSLKRILKQSLKANSMLQMRVPREQDLLSSGYTDRRLLALTKPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K276</accession>
    <name>A0A167K276_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_174493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441025">
        <property type="protein sequence ID" value="OAD67107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285147.1">
        <property type="nucleotide sequence ID" value="XM_018437261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K276"/>
    <dbReference type="GeneID" id="28998167"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174493"/>
    <dbReference type="InParanoid" id="A0A167K276"/>
    <dbReference type="OrthoDB" id="124630at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006912">
        <property type="entry name" value="Harbinger_derived_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47150:SF5">
        <property type="entry name" value="OS07G0546750 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47150">
        <property type="entry name" value="OS12G0169200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04827">
        <property type="entry name" value="Plant_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="170" mass="20008" checksum="B2634F1C7AD21841" modified="2016-07-06" version="1">MEKVLKLTSSLLWWLKLKKFLRGRIEDLRLGTKIRENLCRFCLLRKDFISKFDQVPTLNYYCYLYYFGSGKLYDWGQLRPYIISFRLILNYSSSQYSFTTIINGNTYSQGYYLTDGIYLTYAAFVKSFNDPQSAKHKNFAKTQEAVRKDVECTFVVLQTHFAIVAGPARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K5K1</accession>
    <name>A0A167K5K1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phospholipase D</fullName>
            <ecNumber evidence="2">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_156557</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="2"/>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285366.1">
        <property type="nucleotide sequence ID" value="XM_018433496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K5K1"/>
    <dbReference type="FunCoup" id="A0A167K5K1">
        <property type="interactions" value="554"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167K5K1"/>
    <dbReference type="GeneID" id="28994402"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_156557"/>
    <dbReference type="InParanoid" id="A0A167K5K1"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="8">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="8">
        <location>
            <begin position="531"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="454"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="623"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="623"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD67326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="799" mass="92072" checksum="CF06F2B9D2FB55A9" modified="2016-07-06" version="1">MLGNCSITLENKFRRFEIRGGQREVEEWMESIDKVQSESPWVKTHRFGSFAPIRSNAKVKWFVDGENHFNAVAEAILSAKSEIYIADWWFSPELYLRRPPEKNEEFRIDRLLKRKASEGVMIYVVVYKEMSVALTINSAHTKQWLQGLHPNIIVQRHPDHKIVGEDVFFWSHHEKIIVVDNRLAFIGGLDLCFGRYDTHSHRLADHPAVGHEHKIFPGQDYSNPRSKDFVNVIQYDQTLVDRESIPRMPWHDATIGVVGPIARDISRHFIQRWNFLKTNKSSHRSAVPFLMPKGEYVAARDESNFTGTCRVQLLRSSSSWSSGIEREHSIYNAYMECISESKHFIYFENQFFITVTYSDKLLKNMIGQALVDRIKRAHAKKEKFKVFVIMPLVPAFEGDLASAESASARTVMHFQYTSISRGGNSIIEKLREAGIEPSDYIGWYSLRNWDKLEPPFSAAPPKPKPKQNPKPSTSSKIKKSVDDDTKSPFDDQASLDCDSGIADDPFSDKNNVDSDDSDEYEIDDRDHYVSELLYIHDKLMIVDDVTVLIGSANINDRSLLGNRDSEIAMLIEDTEVVISHMDGKEYRATKFAHTLRMQLWKEHLGLLEFDDWGSLLPKATVNRSPDTLSPESQSHVRFRSHSISRPADHEEDDIFECEAQEPVRVLDRMSRTRSLYDTFNTTKQHSRHLDAAALDPLADHCYYDIWRRTADVNTKIYRDLFRCVPDDTVHTFEQHRQFIPDSSIPQGHVADPSRSGREIRQELNNVRGHLVMFPTDYLKDENMMGSSLLETVTPLVIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KBI2</accession>
    <name>A0A167KBI2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_174015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285726.1">
        <property type="nucleotide sequence ID" value="XM_018437171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KBI2"/>
    <dbReference type="GeneID" id="28998077"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174015"/>
    <dbReference type="InParanoid" id="A0A167KBI2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="112" mass="12511" checksum="F24DA371A6F20F69" modified="2016-07-06" version="1">MKNQLRLCAKKGLDKSKIRAQETFILNFGIKSTDFNPFFPTFSTSNGRSLLQVRTLMGYLIPHHLQAAIIAIIVNFTLEIITASMVADKPTCAICIDFPLFVIFSFPLPTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KED8</accession>
    <name>A0A167KED8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_150991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285945.1">
        <property type="nucleotide sequence ID" value="XM_018432586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KED8"/>
    <dbReference type="GeneID" id="28993492"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150991"/>
    <dbReference type="InParanoid" id="A0A167KED8"/>
    <dbReference type="OrthoDB" id="2279666at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="162" mass="18396" checksum="FE684CDAC686B2A2" modified="2016-07-06" version="1">MPSRSSSANINTNRTLVGMERMERKAMGRKLDLVFYRQLFEYGCYECGRREYQAKKLLHGSKIAKVLKDMLYSLYQRTPGSLRELALAGLLLFVGRVCSISHKRNLDLAEETDAICTALLPILAAVYKSIVMMENTNKLAKQKLVDIDLDLDLDIDQCKTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KFD1</accession>
    <name>A0A167KFD1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_160321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286015.1">
        <property type="nucleotide sequence ID" value="XM_018434160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KFD1"/>
    <dbReference type="GeneID" id="28995066"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160321"/>
    <dbReference type="InParanoid" id="A0A167KFD1"/>
    <dbReference type="OrthoDB" id="2222427at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="67" mass="7547" checksum="041F326A148DA8DA" modified="2016-07-06" version="1">MESSTPVLWPTPRHMVSSSSTMAALSPRYIDQCVKSNPRQLIKVDILGDTVELPVYALRRRNALVHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KGG1</accession>
    <name>A0A167KGG1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_188782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286077.1">
        <property type="nucleotide sequence ID" value="XM_018439561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KGG1"/>
    <dbReference type="STRING" id="763407.A0A167KGG1"/>
    <dbReference type="GeneID" id="29000467"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_188782"/>
    <dbReference type="InParanoid" id="A0A167KGG1"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="1">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="104" mass="11912" checksum="67FB840E8678D817" modified="2016-07-06" version="1">MSQQPRRFNDQQMVKAFLSDNCLSQYCERMIDEGFDQLRSVYDVTESDLASMGVKRGHRRMLQKAIADAKGTSPSLSVDTDKNGPGKYMGEHSMLIRWLQSTQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KRA3</accession>
    <name>A0A167KRA3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_188654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286736.1">
        <property type="nucleotide sequence ID" value="XM_018439543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KRA3"/>
    <dbReference type="STRING" id="763407.A0A167KRA3"/>
    <dbReference type="GeneID" id="29000449"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_188654"/>
    <dbReference type="InParanoid" id="A0A167KRA3"/>
    <dbReference type="OrthoDB" id="2289822at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="511" mass="56386" checksum="4627602DC167C322" modified="2016-07-06" version="1">MVVKTPSGDISAKVHVLMTTGDIPALGKMACHVGHMSKDGCRICHVVGQSPGHGQYFRMPSAITMRTPESFKHFDEVASSSKKGLTGQSPFSLLDSFSGPFFFALDEMHGICHGIGKQVWGLVCGKYGKDHPLSLSLVAQKEIGTAMVSTRRSISTSFHGAWINIATRSGYFRAVDWADFILFVIPTLVAERVRDQAARKALLDLVQTCNLLMSWELSAEEKTLIKTNLVAWNAYLEVSLAKGEVQLKVFTINQHLLQHYPAMIEAYGPPRAYSARSVERAIGEYSRAIKTTVTATTLLQYDDPSAGWPIDREGSNVGTDSDIEFWGPLRNRTIVDSFGGISCIPELLQKFYESKGEECSMIEAAIKTSRKAFVNGCVIDSALDHNCVREAHNVRLQVQVDENRNIGQSYSPVYKDFFGKVVVFFEHKLNNKRCPLVLVNVYAVRLVNSIPVVNNGQMKPKVVHLADVKELVGLVKSDATINITTTATTTYIVWPELNRGPKLSLGSLADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KRV4</accession>
    <name>A0A167KRV4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_150330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286777.1">
        <property type="nucleotide sequence ID" value="XM_018432454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KRV4"/>
    <dbReference type="GeneID" id="28993360"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150330"/>
    <dbReference type="InParanoid" id="A0A167KRV4"/>
    <dbReference type="OrthoDB" id="10276297at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="113" mass="12423" checksum="EE9617C6DE928A17" modified="2016-07-06" version="1">MLERNHGMYSICNCSSTNISYGLLWSQLQPGIDAACFWSKLMKIFNVVNTGPLVTHAPLESPPEMLNGVEIQALSRPVVKTSDLMDIFPPPLVRPSMTAGVALLEHETPVLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KSZ7</accession>
    <name>A0A167KSZ7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_150400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286848.1">
        <property type="nucleotide sequence ID" value="XM_018432473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KSZ7"/>
    <dbReference type="STRING" id="763407.A0A167KSZ7"/>
    <dbReference type="GeneID" id="28993379"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150400"/>
    <dbReference type="InParanoid" id="A0A167KSZ7"/>
    <dbReference type="OrthoDB" id="2292686at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="112" mass="12599" checksum="2ACBFBF12A3AFD77" modified="2016-07-06" version="1">MSTNNIQSNKNIYTLATISEALECTSVPGVITLRLDTTIKVRTSEWRDCLLEIGESCAVKWIIHNSNKQPTDITAEEAKDSDIKMCFSQEYSCHHAGTYESKAAMRVVQKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L961</accession>
    <name>A0A167L961_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_116015</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287918.1">
        <property type="nucleotide sequence ID" value="XM_018428492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L961"/>
    <dbReference type="STRING" id="763407.A0A167L961"/>
    <dbReference type="GeneID" id="28989398"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_116015"/>
    <dbReference type="InParanoid" id="A0A167L961"/>
    <dbReference type="OrthoDB" id="441771at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007276">
        <property type="entry name" value="Nop14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183">
        <property type="entry name" value="NOP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04147">
        <property type="entry name" value="Nop14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="98"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD69878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="168" mass="19910" checksum="EA0BDBF46BCF8A7E" modified="2016-07-06" version="1">MIERLLQLYASTSALVELFQQTLDIVRILETVSWHSEIESVLGELSNRLERQIKFCKDKRVKTPLRMQMHRPIPIAQHLPKFEKGYSMDRHYDPDHERAQANKLAAQHKKEKKGALRELRKDNMFLAREKAKVRKQKDEDYNKMIKGVMTVLEGEQGEQNRLDRENKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LB63</accession>
    <name>A0A167LB63_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_60362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD70038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288078.1">
        <property type="nucleotide sequence ID" value="XM_018440633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LB63"/>
    <dbReference type="GeneID" id="29001539"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_60362"/>
    <dbReference type="InParanoid" id="A0A167LB63"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="142" mass="16101" checksum="5153DBAA2AA13781" modified="2016-07-06" version="1">MKEIQPLGLNTCESIDSGTSNLQKLKWNTLQETLDHDNDITEKTFWAIGNQHITAVLLDSLNIDQILLLSTSLLKPIIEIIILHLLKLHSQVVNSISKCYCEIVTIFERVVQILSAFVKAILKQFVAYSVITIEKCVQLLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LVI0</accession>
    <name>A0A167LVI0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_170557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289218.1">
        <property type="nucleotide sequence ID" value="XM_018436373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LVI0"/>
    <dbReference type="GeneID" id="28997279"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170557"/>
    <dbReference type="InParanoid" id="A0A167LVI0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="116" mass="13790" checksum="3B8CE615C81AA737" modified="2016-07-06" version="1">MLKTNLEKQYVGLGNAYYICGYSQNSINPVKICFIFHCIFANHDKIDMWVVQVSKTIIYAIVLVYMKEKRRVLIDGKYLTCVTDVLISSLYFFNYVPLYYPLHQYVPILYRKYSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LZU7</accession>
    <name>A0A167LZU7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_182265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289474.1">
        <property type="nucleotide sequence ID" value="XM_018438596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LZU7"/>
    <dbReference type="STRING" id="763407.A0A167LZU7"/>
    <dbReference type="GeneID" id="28999502"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_182265"/>
    <dbReference type="InParanoid" id="A0A167LZU7"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="663" mass="75613" checksum="1C18988631DAD8FC" modified="2016-07-06" version="1">MLIMAEENKLFDVIVGIDFGTTFSGFSCEVIPEKKEPPKPETANTTKAKKKGNYAPELLLKKTSSAMYFKKDEKKIFEFGDKAEKANEDYKYPETKTEPKTEPKTEITTGTEAHTNSNVEPDVANNTEDKTESNPGDLVRRTKLLLDRTIKNHPDLPARLTLVHAVSRYLKKIRRNIHIEIETKYGHDPKLLKYKYYITVPASWSKQSRNIMRDAAISSKLVEKHNVDTQLEIIDEPVAAAVYAESKNTDIKFKKGDRYMICDAGGETVNLAVFEKDTIEGQKSLKEITFGAVTPSVSSLLDALFEELLEKRLPEWSEKGTSQPEDTQASTEENIGQDSIDIIENSLEKINEIIKATHKDIENNPKIFTPEEIRTEMFYPVVEIILKTIKKQIEIQKGIQRTEQDNQPDERKLKAIFITGGLGQSKYLQDKIKEKFGEEVEDNNIIGVEEGIMAVMKGAVLIHSNPIEISQKIHRRTYGIRLRPPQKKPPGSNGKTDRSNSLIESEKNVEENDYENDKKEKEKNRFHVYIRKNDPVIDNTWITKKMYWKAETLKVISLCAYNGDGEPPTHPKEEDIDTVITLDTGFSINKKDNSSSLEILILKMSFDIDIIDIKGSISNLEFKYPRVEDLTGEKNTLPFIEINPAPFSKFQKIFPFLRRTSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M2G6</accession>
    <name>A0A167M2G6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_147320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289617.1">
        <property type="nucleotide sequence ID" value="XM_018431841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M2G6"/>
    <dbReference type="GeneID" id="28992747"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_147320"/>
    <dbReference type="InParanoid" id="A0A167M2G6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="128" mass="14509" checksum="5AA5FB24557BF019" modified="2016-07-06" version="1">MLKEVVATPQLEDIFTNICSQQLPRLLSYFPAPRKTWASIHQQLSSLPTLLNQDVTDTPPTNKDSSLKMNMSSPELQAESITPSLTGQWHLFRKFYLSSYINKSKANEHPAKYLRAEFGPDRVLAMGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MB15</accession>
    <name>A0A167MB15_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Maintenance of telomere capping protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_187355</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MTC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290369.1">
        <property type="nucleotide sequence ID" value="XM_018439371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MB15"/>
    <dbReference type="STRING" id="763407.A0A167MB15"/>
    <dbReference type="GeneID" id="29000277"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_187355"/>
    <dbReference type="InParanoid" id="A0A167MB15"/>
    <dbReference type="OrthoDB" id="2274918at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051008">
        <property type="entry name" value="Telomere_Capping_Maintenance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057530">
        <property type="entry name" value="TIM-barrel_MTC6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35518:SF2">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35518">
        <property type="entry name" value="MAINTENANCE OF TELOMOERE CAPPING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25506">
        <property type="entry name" value="TIM-barrel_MTC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="MTC6 partial TIM-barrel" evidence="11">
        <location>
            <begin position="78"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD72329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="559" mass="64245" checksum="3E0060CADA947D3A" modified="2016-07-06" version="1">MIKNLIRVEDASSPSTGKVFGFLQLYKLVMDLELCIYLPGMKLLGIFFSLICLLTWSCSATFDDSIDDVQQLNNVLDIKDSLRVQRDISCNVTINHYLWPAINLTSSYFGTNFSKMQLDSIDALLELGYMRLEFDIYWDSTYEIWELCPVEVSDKNSTEDQTINQFTCTIHSLEIFLGSINRYLVSTQVPKAPLKTNLVMLILHIHGTDNQSHPLTLLSEIISKTIISSTAYTSRIYTPNDFIYDQKNKPSNSTWWPQWIQLVERHFQLLVGFGEIQAEVNSSNKTMSNEGILFGAGTFGVPTYFENSTFVQDTCYKALENPLSEPPSWSLVDKKNQSLNSAEISQVIHCGQSPMLDISVSSTEYRDLLQKTIENTLWSWDEGQPPKDNKVACAAIQQSNGRWRVEDCSEQLNVACRHRNEPGKWVVANTTASYDQAFLVCPDNYLFDTPRTAWQNQQLFYTIQRDYIDPSTEEKSQDRAVWINLNSAISAQCWVVGQSDLCWWLNKAILILFGFFTWVKCARLWRLRRSNQRKRIAQHMLARRDYVTVPYNLLVRGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MEW4</accession>
    <name>A0A167MEW4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_73061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290694.1">
        <property type="nucleotide sequence ID" value="XM_018442766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MEW4"/>
    <dbReference type="GeneID" id="29003672"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73061"/>
    <dbReference type="InParanoid" id="A0A167MEW4"/>
    <dbReference type="OrthoDB" id="3261594at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="544" mass="61677" checksum="6BE8FFB5C18EBDF7" modified="2016-07-06" version="1">MNTNTSATRISGSDSDISATYYIDIAQDFVALAPSLQERNQSLFNSANQASSDEVHVHDQDIGRAEENDFEAFMAPESVYSISNSVDVEFNNDYTETNEAEYNDSDNSNDYLYESVHRYSRIRNPVNINTLLIESDFVTKNVNQESYIPFYEPNTYAEAATLKFFSMFVENNVSHNVFDKCIKIVNKYMAEHGLPATNALLSYYKMDKILKDKYTVCTATYDMCMEGCVHFRDVEASNLIDEKEQCPHCGSQRFRCERDTLVSVQTFKVVHLSQQLRFKLGNSQEHAKMAYGRSHIMGSRFGVLSDVFDGGAVCRLCEGSIVCQDDILVTMFIDQFNPFDDTKMLATIIHVVNLNIDLKERYESDNMMQLAIIPGPKHPRDIGSFLEPIIKDFRMLATSGIQIQTVAGQINSYSVNGPNVFRDLPTLTSSAFFGLNEMHLLEHDIGKQLYKALGGKLNQIDRSITKSRADITTIFTVSWQSLEETTGRQKAVNWLDFLLFVVPMVVVNNFVLAKTRNAVQDLVKACAIAQQWKVTEREVNIMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MF51</accession>
    <name>A0A167MF51_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_145992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290716.1">
        <property type="nucleotide sequence ID" value="XM_018431575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MF51"/>
    <dbReference type="GeneID" id="28992481"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145992"/>
    <dbReference type="InParanoid" id="A0A167MF51"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="237" mass="26170" checksum="CA2D9B45A5C6B532" modified="2016-07-06" version="1">MIEVYGPPRAYSARSVDRAIMKYSQAIKSNLAIGINTGNIMFGLTQIRQMRVENSTMTTATVTATTLLQYDNPSAGWPIDQEGSNVGTDSDIEFWGPLKNRMIVDSFGGISCFLELLQKFYESKGKECSMIEAAIKTKLLQDFFGKVVIVFEHKLNNKRWSLVLVNVYAVRLVNSIPAINNGQMKPIVVHLADVTQLVGLVKLNTTINTITITATAYVVWPDLNHGPKLSLGSLADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MGX3</accession>
    <name>A0A167MGX3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sorting nexin-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Autophagy-related protein 24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_113478</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290849.1">
        <property type="nucleotide sequence ID" value="XM_018428345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MGX3"/>
    <dbReference type="FunCoup" id="A0A167MGX3">
        <property type="interactions" value="227"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167MGX3"/>
    <dbReference type="GeneID" id="28989251"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_113478"/>
    <dbReference type="InParanoid" id="A0A167MGX3"/>
    <dbReference type="OrthoDB" id="205639at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949:SF2">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD72809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="410" mass="47836" checksum="3FD009EBE94BEEA6" modified="2016-07-06" version="1">MVIRLVETEKHMDSPQGAYVAYLVSCMTSLRTFSSHQSRPVWRRFQDFVWLHNALTLEFPACIIPPLPDRRRLEYIKGDRFSTEFIERRKWSLQWFMDRISKHPQLQLSQSVRIFLESNDFVRMQSRRISPAASVLESIGGSLFTAFTKVKKPDERFVEMKDNFDKIQDNLDTVERLYTRISKRQHVLHNFSLDLQHDYAGFAESMQGFSVRESEIASPLQKFSDTTREYSMLIKTMAKDVLFLNEIHELLAYCHSAKAALRARDQKQVEFEALSGYLQQAVQERERTLYPTRYSSGSSLNITDFFTEKLNEVRGIDVQRARREKLEKLDHKIKELEGEVARANDISNSFSSQVLKESDIFEKAKNKELKQGLTAYADSHIDFFKKGAHAWEKILPVLESIDVGDIDQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MSE7</accession>
    <name>A0A167MSE7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_64743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291824.1">
        <property type="nucleotide sequence ID" value="XM_018441345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MSE7"/>
    <dbReference type="STRING" id="763407.A0A167MSE7"/>
    <dbReference type="GeneID" id="29002251"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64743"/>
    <dbReference type="InParanoid" id="A0A167MSE7"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10229">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD73784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="63497" checksum="966E24ECF6275361" modified="2016-07-06" version="1">MAGRILDNEFDNYSYIVGIDFGTTFSGCSYIYIKSSINEIFDITDWPKRSGYIYPKVPTVLFYEQNSKNLIAWGYDAIQRAKRPDTMGVLIDKFKLHLDHSQTYPALPNGLTVLEVITDYLREFNLYIHTCLKDKLGVIYNSSNFKYCLTVPAIWDDQAKAIMREAAVLAGIVDRSDNPDRLILTSEPEAASLYCEKKSGQFNLKHGQRFMICDAGGGTLDLIVFEIDTSSGDASLREVTKGSGSTCGSTFLDRNMRDLIIKRFGTYADGNKEIIDNLIDHFVASTKPQFDDEDDEFFTIPISLGLNEEILANIGVADGRLQVTVDELREDVFEPVVKQVLDLISDQINQSRTQIDAIFLVGGFGQSRYLGRRVKEIFKPKVGSIYVPSRGEMAVVRGAVMFGMDPNKVTHRILRRTYGLRCGSIFDALRDPPEKKYIDYDGVTRCHDRFSIFATKGESMAVNKCVSNEYFVFYPGPFNSDLFAYDFDGSSPRYTTDLGVRKVAKFSKELSIFTNVKLGDKIFFTTNMYFGKTEIMIETLIRGEKFTYTSSFASHELEKTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N6S1</accession>
    <name>A0A167N6S1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_167479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293200.1">
        <property type="nucleotide sequence ID" value="XM_018435648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N6S1"/>
    <dbReference type="GeneID" id="28996554"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167479"/>
    <dbReference type="InParanoid" id="A0A167N6S1"/>
    <dbReference type="OrthoDB" id="2379842at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="197" mass="22844" checksum="A8270FC9F2664474" modified="2016-07-06" version="1">MEVYQDQEEWSKVKDKMLETFLKHQNNYYHGRMEHGNMPASNNPLIRSLQDKRSPLPQQHWFGTIDHPQLVADTFSRAVAVYWNTPIETGDCLFVPFATLPEKVEPIIIILDFFNLLAFACLISVQFAGARPEGKLASYMDFLVQIAQNELTTYAHKILLLNSFGDIPDFERLIRHFDLNDLLLLNSSSFQWEVQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NAR4</accession>
    <name>A0A167NAR4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_166756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293559.1">
        <property type="nucleotide sequence ID" value="XM_018435476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NAR4"/>
    <dbReference type="STRING" id="763407.A0A167NAR4"/>
    <dbReference type="GeneID" id="28996382"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166756"/>
    <dbReference type="InParanoid" id="A0A167NAR4"/>
    <dbReference type="OrthoDB" id="2284923at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="551" mass="61916" checksum="A4BB45571FE11352" modified="2016-07-06" version="1">MPTHEALDILSAIPLTDDTIICGDFNARLGSVTGDYASNPRGVALEQWLEERSLTVLNGVLSPCTPTYISFRNKVEISSIIDLFITNTNFANPSLHIATKLSLGSDHRLLSLSFTYDLQHSPPAPPPMCQTWNLSRLYEEDVRSLYVTTFVTKSASILTTLQDLVQNPPTICPPIDTLTNSFNALIYDSLSSSIGSRPPRPSHWKSFWTPALQAAADHRDDSCGIDKINWWSRHQHAHKEFRQQVQTAKHLSWHAFCHSMNSDFNKATSKIKQLKRRRQLQHTFQHDDGPAVAATVMCDHLASVYSGHILPDIRPSPPPLNISLMPFASVDSPFTSSVVEAFMQFMPNRKAPGPDHIRAEMLKPIWSHISPLLACLFTICWQCMSFRADVLITKFCIRAHYLPSGCLLSLLHRHHSQSSSLVTLCHNTLLQSIPIDLNVHSGKALKHHFETFQQFKTDQLRLSSNQVLFLACCPLLEVNSILFLPATRVERSRLVRWRMGWLPGTPKNCPCGTDHTSRRHLAVCSLVPGHLLACLPIPSDQNYNPIDFAIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NYX9</accession>
    <name>A0A167NYX9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_165405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294946.1">
        <property type="nucleotide sequence ID" value="XM_018435230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NYX9"/>
    <dbReference type="GeneID" id="28996136"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165405"/>
    <dbReference type="InParanoid" id="A0A167NYX9"/>
    <dbReference type="OrthoDB" id="6621790at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="66"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="172" mass="19121" checksum="EC7B7052CCDA72F1" modified="2016-07-06" version="1">MISRIDSHSTNAQVSGSCCYIRSSLLPSTNNSNDDSLVYTTSSRMSIDEAGGSTSISLFILSSSLYCSIYVSPLCQLNTLMEALEFVVSHTYMHITIAGDFNVDFTKESIKKMTLLQFMNNRNMTTTLPNTIQSTTSQNTLIDNIFSTMPVLDSGRYISLTSYHSPLWAKFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PCB5</accession>
    <name>A0A167PCB5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP deaminase</fullName>
            <ecNumber evidence="4">3.5.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Myoadenylate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_176970</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="4"/>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295689.1">
        <property type="nucleotide sequence ID" value="XM_018437840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PCB5"/>
    <dbReference type="FunCoup" id="A0A167PCB5">
        <property type="interactions" value="423"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167PCB5"/>
    <dbReference type="GeneID" id="28998746"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176970"/>
    <dbReference type="InParanoid" id="A0A167PCB5"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01319">
        <property type="entry name" value="AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000035">
        <property type="entry name" value="Probable amp deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="124"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD77649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="799" mass="93256" checksum="E3A4345C10D3F843" modified="2016-07-06" version="1">MASIQDQEEVPKSPEFLSSEGTPTGDLDNTPFFKYKEQRAIVDQDSKYLCHNLPINPALDEEIEPRTILHPVVNTGTPPPVVDSTIHSEQETGHTITTELRELYSSLHRCLELRDKYMIRSRQRLNDNPKNRSDWKIYPEPPPRSWPLPSPEELERRRKKEHEREMDPIAAVGSDFDFESCEFPSKDENYTYGLNPEGFYEVYASDHDKKQHRPICNIPHRKEFYEDMDFVLNTISDGPAKSFAFRRLRYLDGKWQMYILLNEFQELADSKRVPHRDFYNVRKVDTHVHHTSCMNQKHLLRFIKSKMKRSPDDVVIYRDDKHLTLAGVFESLGLTAYDLSIDTLDMHAHKDSFHRFDKFNLKYNPIGESRLREIFIKTDNYINGRYLAEITKEVVSDLESSKYQMVEYRLSIYGRSKSEWDKLAKWVVNNKMFSPNVRWLIQIPRLYNLYKSSGAIENFENVIKNVFEPLFEVTKDPSSHPELFVFLQRVVGFDSVDDESKPEKRIFKKYPAPRDWTNKSNPPYSYYIYYMYANMTSLNEWRRQRGFNTFVLRPHCGEAGDTEHLTAAFLTSFGISHGILLRKVPALQYLFYLAQIHIAMSPLSNNALFLTYERNPFPQFFQRGLNVSLSTDDPLQFHFTKEPLIEEYSVAAQIWKLSSTDMCELARNSVIQSGWENKIKQHWIGESWSEPGVAGNDMQRTNVPDIRVKFRHDTLTQELNALRRYGTMDGKSAEEQLEDLESEPSQHDMVGLAGVTDPIHLQQDFIHARNDPLDPSMGQFPGAAMVAERAKRKTHSCLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PP73</accession>
    <name>A0A167PP73_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_107337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296328.1">
        <property type="nucleotide sequence ID" value="XM_018427992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PP73"/>
    <dbReference type="STRING" id="763407.A0A167PP73"/>
    <dbReference type="GeneID" id="28988898"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_107337"/>
    <dbReference type="InParanoid" id="A0A167PP73"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="2">
        <location>
            <begin position="85"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD78288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="388" mass="44699" checksum="8BFD4062CAA8B67D" modified="2016-07-06" version="1">MATKRNTQEAKPVDLDLDEAITRGWELPDINLKEIRDSIPAHCFRRDTFRSFTYVLHDFTLIAIIGYGATWIDTLSSTPLRYLLWNLYWIAQGIVATGVWMLGHECGHQAFSPSKTINDTVGMILHCGLLVPYFSWKFSHSRHHKSTGHLTRDTAFVPRTRSSYGLPPLNEDPEMDGPHSVFEETPIVLLFDVFKFLFFGWPYHLLTNAAAQKGSGWMSHFNPNCEIFEDSQRAEVFQSIIGVFSVIGGLFYASSIYGSMAVIKFYVVPYFYVHAWLILITFLQHTHYDLPHYTAKTWNFQRGASLTVDRSFGTILNHFHHHICDTHVAHHFFSNMPHYHAEEATAHIKKSLGKHYHYDATPIPVALFSTWKSCRFVEDTGDVRFYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PR94</accession>
    <name>A0A167PR94_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(2)-C6 fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_163505</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296428.1">
        <property type="nucleotide sequence ID" value="XM_018434808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PR94"/>
    <dbReference type="STRING" id="763407.A0A167PR94"/>
    <dbReference type="GeneID" id="28995714"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_163505"/>
    <dbReference type="InParanoid" id="A0A167PR94"/>
    <dbReference type="OrthoDB" id="2278435at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="644"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD78388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="727" mass="83239" checksum="553D91ADC36267EA" modified="2016-07-06" version="1">MSTIDENENTKQKRNRPCENCRAHRRKCIVLQGMQCERCRKMSSCCLFKFTARPLMAKRAIPLSKKNRVWNEIWELEQEAEDLQEQLRALHITAKVNKRPRKQLLPTNNYNTVEQKVAQTENTACECIDASKCTHLNPKNSYSDQWQLTLSKTTNGIQFQTNINNFSDMLVFIREAAPYLSISPQHTLSFITKRSKGMIVTNCLLKIESVIRNTFSTTAIENEEPKNSIIVKNQNERYLAKLLFIDIYFSCYGMLNPILIHYYYYNYLRSNPDSLLSTSIAAFVGYSQCRHAPKTFGSYTREELSESFRKEAQELMRDALFDNLDGPTLETTFSIALLSFVSVLTTNMQEARLYSSTSWRMVIQLKDTYRHILHLPLSEAIEKVGPLGIIKAETWRRMFYIIRYVETYLYMMLDNLNDFSDILFPIEIGHPTPLPYEMADTAIYEAVKVYCDYVRLISISKVYDNGKHTSVISYRLQAGSLKVIPSNAVEMIENQLFEFWNSLPPSHRVSDQPMSYIQTDHIHQCVNTRVLYLNVVYYVNWLNLQTRIMDPPKYCDLSDASLGCIDGKRALIIVSMSSDAIVKILHVLHLRLPCALDLHLLILAIDALALLRSSPNRDIRDRADQGLKQAIKVLHDRASHARSPLSSPSLAENNCNSRSCSPEAMQEANEISWSVSSCSSVSGPQSPGNTEDYTETIPVNYEGDKIHSIGYLGWMKKQLGSISNDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PU13</accession>
    <name>A0A167PU13_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_179587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296577.1">
        <property type="nucleotide sequence ID" value="XM_018438171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PU13"/>
    <dbReference type="STRING" id="763407.A0A167PU13"/>
    <dbReference type="GeneID" id="28999077"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179587"/>
    <dbReference type="InParanoid" id="A0A167PU13"/>
    <dbReference type="OrthoDB" id="10052260at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="142" mass="15904" checksum="61C34F717C00AAE8" modified="2016-07-06" version="1">MTSLLSPDTRIKVSSVLNRDTVSYGKQHLIDGSEETCWNSEQGLPQNILLDFGSPVEVQKIALTFQGGFVGKTCVALGSSPSSPNNYNIQLSTFYPEDINPTQIFDIQHKEPIQRLKIIFEESTDFYGRITVYKLDVIGVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PXP4</accession>
    <name>A0A167PXP4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_62516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296767.1">
        <property type="nucleotide sequence ID" value="XM_018440978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PXP4"/>
    <dbReference type="GeneID" id="29001884"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_62516"/>
    <dbReference type="InParanoid" id="A0A167PXP4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="129" mass="14746" checksum="EEBE5E2F7A03EC68" modified="2016-07-06" version="1">MAYFPLASKMARVPLGLKLGLLVRVKVWVLPSRAIEALVESAALTADNEIVSKKIAIIEKNFTINTEEPWGGQIEKVKTWSKTVEIRSPNLVQENTFDFAARKTAQYIGEYYYRFQRFAEEISDDMQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q323</accession>
    <name>A0A167Q323_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_179771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297018.1">
        <property type="nucleotide sequence ID" value="XM_018438205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q323"/>
    <dbReference type="GeneID" id="28999111"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179771"/>
    <dbReference type="InParanoid" id="A0A167Q323"/>
    <dbReference type="OrthoDB" id="2235549at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007891397" evidence="1">
        <location>
            <begin position="22"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="108" mass="11486" checksum="71C563987A22001C" modified="2016-07-06" version="1">MISSRAASIVLVPVAAAAAYATYVRNTVQPSLAYSSIMSQGSNPSAQEQWRKVNKGLGLVDVGRSCGAVDTNGNFNGNVDVDVHVKYLFENEEEIVDHQVPCGTSVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q5E3</accession>
    <name>A0A167Q5E3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 18">Serine/threonine-protein kinase RIO1</fullName>
            <ecNumber evidence="4 18">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PHYBLDRAFT_120971</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4 18"/>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297138.1">
        <property type="nucleotide sequence ID" value="XM_018428772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q5E3"/>
    <dbReference type="FunCoup" id="A0A167Q5E3">
        <property type="interactions" value="938"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167Q5E3"/>
    <dbReference type="GeneID" id="28989678"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_120971"/>
    <dbReference type="InParanoid" id="A0A167Q5E3"/>
    <dbReference type="OrthoDB" id="205248at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05147">
        <property type="entry name" value="RIO1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000148">
        <property type="entry name" value="Serine/threonine-protein kinase RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017407">
        <property type="entry name" value="Ser/Thr_kinase_Rio1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038147">
        <property type="entry name" value="Ser/Thr_PK_RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 18 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 18" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="23">
        <location>
            <begin position="180"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="153"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="502"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="505"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="563"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="19">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="19">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="OAD79098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="585" mass="66849" checksum="8AA8B71E2B77064F" modified="2016-07-06" version="1">MSSEITTKPTTESHADAFADAEEIDESELAYQEDSDDDDYDDYLDDELNDTDLWDSASGDFTKQYNRLRQQVAPVARAGPAAPSFSGASTTTTITTTTTTTTAIAPAANKKTKTATNASTAKEDVAAKKQLLESQIESLSKFTSRIQVRAYEPPRMSSSVASDIKLSSKKASGERNTQKDKSDRATVEQVLDPRTRIILFKMLNRGVFYEINGCISTGKEANVYHAATEDGLHRAIKVYKTSVLTFKDRDRYVTGEYRFRHGYSKSNPRKMVKVWAEKEMRNLRRIKAAGIPSPEALVLRMHVLVMEFLGDKNGWAYPRLKDAQIEQSKYASLYYQLIKNVRTMYQVCRLVHADLSEYNLLYHKGLLYIIDVSQSVEHDHPHASEFLRKDLSNVTDYFSKRGVRVMGLMDLFSFVTDPSFSNEDAVVDDVLEKIQTKMNSEPEKERNTLEEEIFMRSYIPQTLEEVIDVERDTLLIAEGEGKDVSIILYFRLSWLSIKKSKKDVEESEDNDDDDSEDDDSEDDSEDDSEDDGGRKKPLRGKKNEDKDDKKDRKKKAKEEAREKRKHKLPKAEKKRKIKISRNRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QEZ3</accession>
    <name>A0A167QEZ3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminopeptidase P N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_157277</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297638.1">
        <property type="nucleotide sequence ID" value="XM_018433589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QEZ3"/>
    <dbReference type="STRING" id="763407.A0A167QEZ3"/>
    <dbReference type="GeneID" id="28994495"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157277"/>
    <dbReference type="InParanoid" id="A0A167QEZ3"/>
    <dbReference type="OrthoDB" id="10261878at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000002">
        <property type="entry name" value="Xaa-Pro aminopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF1">
        <property type="entry name" value="XAA-PRO DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD79598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="448" mass="49425" checksum="FD4E53BEC70411FD" modified="2016-07-06" version="1">MSPKLPTRQNVQSVLNHLNSSEGVIYLKGQVMTERDDTDVEQAFRQESNFFYVTGVAEPGFHVIIDIASQHIQLIAPVVNADDVMWMGMPDSISALIEKYDVDTVIYEDQLDQRLQSSSVVYTLPTTKVTGNYNLANLEQVAALKVAFGEARAVKKDWEIEIIRQANKISSDAHVKLMESVEVGSNEAQLHALFLYESARRGAFFQAYYPIMGVGMNAATLHYNKNNAPLTNPSDLVLVDAGAELDCYASDITRVFPVGGKFTPEAAAIYNLVLDMQKACLAACKAGSAWEYIHQIAVEVACQGLLDLGILQGEKQEVLDSDVVAAFYPHGIGHMLGLDVHDVAGYPTGVERIDRPGYRYLRMRRNLAPGNVVTVEPGVYFCDFLIAPVLEDEKTSKYVNQEALNKYKSTGGVRIEDNIVITEDGYINLTTAPKEIEEIEALMTASKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QI77</accession>
    <name>A0A167QI77_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_75635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297770.1">
        <property type="nucleotide sequence ID" value="XM_018443083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QI77"/>
    <dbReference type="GeneID" id="29003989"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_75635"/>
    <dbReference type="InParanoid" id="A0A167QI77"/>
    <dbReference type="OrthoDB" id="2267507at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF5">
        <property type="entry name" value="F-BOX AND LEUCINE-RICH REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="671" mass="78077" checksum="DA6062FB0519CEED" modified="2016-07-06" version="1">MMLVFELPFEVLVRIASLLSLEDKLSCTAVCKAWKPLFQESLWDTLYIQNERKLIDICYSTASHNCIYPENGSRVKEIYMSKGLLPSIEEIMVIQRMFHNTDLLYAPLRVLGSPDIQKFTESYSWKSLTCLEIIIDGFDSPVERIPSFIKATAYLPCLTRLEFVKNYTESSLIYTINDIEDLHSNLPHLKYLSLNGGVSDITTNNMIIFSHIIPAKCLTVAKLDLESMDIVWLYYSMCKYSNIKSLHWNISKSLIAQDDFIDYINIQIKKIPNPLKYMNTLVIKDTWCNEETYEYLYKLISYHKPPISHIKYSKCITYHTENELYLLSDNIRNLVGAFSQSLQKIEITTNANFSDINTIMKELGSCPDLVELHLSLSNTLIDIDVLLNHCVGLKKLKLSGKRVFISSDVPENTTPHGLCLLEVSRTIANTNLFYYISFRCRHLKYMHLNYMNVFGTFTKSTRGIVINMPHTHLQLLLLNCVSFCTEHGSEYSNEGAVNLMTSMKPRIIVRQTNLMTRLQHSDASYQKSDQEKKVQLQIYWTPIKQRDALKEVLSRRREPLYSHEYSKLLDIQPTNSRRKSSCFFYRAQMIFKFLLCGALFFMNQDKRSVSSKMKLEIIEHSLNFAHFDYKRIQSFINQSFKKNLKSNISYSYRYFCFSGKTACRNESLTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QID6</accession>
    <name>A0A167QID6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_75637</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297780.1">
        <property type="nucleotide sequence ID" value="XM_018443084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QID6"/>
    <dbReference type="FunCoup" id="A0A167QID6">
        <property type="interactions" value="462"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QID6"/>
    <dbReference type="GeneID" id="29003990"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_75637"/>
    <dbReference type="InParanoid" id="A0A167QID6"/>
    <dbReference type="OrthoDB" id="10258210at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_uS19_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003121">
        <property type="entry name" value="PRK04038.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD79740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="19100" checksum="6288BBE29E78A6E7" modified="2016-07-06" version="1">MWYIKINKYRAADLSGIEGTADQEQTNLRKRTFRKFTYRGIDLEQLLDLSSEQFMALVHSRARRRFQRGLKRKHMGLIKKLRNAKKEATPGEKPATVKTHLRDMIIVPEMIGSVVGVYNGKTFNQVEIKPEMTAHYLAEFSISYKPVKHGRPGIGATHSSRFVPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QPE3</accession>
    <name>A0A167QPE3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">biotin synthase</fullName>
            <ecNumber evidence="3">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHYBLDRAFT_121630</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="13">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3"/>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298050.1">
        <property type="nucleotide sequence ID" value="XM_018428819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QPE3"/>
    <dbReference type="FunCoup" id="A0A167QPE3">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QPE3"/>
    <dbReference type="GeneID" id="28989725"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_121630"/>
    <dbReference type="InParanoid" id="A0A167QPE3"/>
    <dbReference type="OrthoDB" id="2414104at2759"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000011">
        <property type="entry name" value="Biotin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="BIOTIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976:SF2">
        <property type="entry name" value="BIOTIN SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01060">
        <property type="entry name" value="BATS_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00272">
        <property type="entry name" value="biotin_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01278">
        <property type="entry name" value="biotin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="14">
        <location>
            <begin position="85"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAD80010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="390" mass="42707" checksum="2129E7C4A02AA7EE" modified="2016-07-06" version="1">MSAFRLATNPLRSAKRFYGSATPSRLASIQNIKASGPAISAAALHADGPLRNDWSREEIQAIYDSPFMDLMYFGAKVHRANFNAREVQQCTLLSIKTGGCTEDCKYCPQSSRYDTVVKAQKMLDNDEILKAALRAKDAGSTRFCMGAAWRDLAGRKSNFSKILNNVKTIRGMGMEVCCTLGMLNETQAKQLKEAGLTAYNHNLDTSREFYPKIITTRSYDERLETIGHAQDAGISVCSGGIIGLGEQEEDRVGLLHTLSTLKQHPESVPVNALLAVPGTPLENQTPVSVFEMVRMIATARIAMPKSMVRLSAGRVKFSVSEQAMCFMAGANSIFTGDKLLTTPNNDATEDQKMFEFLGLVPKPPNFEQGADKIDQPSYQNGIKIKAEVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N1Z8</accession>
    <name>A0A162N1Z8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_174029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285738.1">
        <property type="nucleotide sequence ID" value="XM_018437172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N1Z8"/>
    <dbReference type="GeneID" id="28998078"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174029"/>
    <dbReference type="InParanoid" id="A0A162N1Z8"/>
    <dbReference type="OrthoDB" id="2253782at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31639">
        <property type="entry name" value="F-BOX PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31639:SF256">
        <property type="entry name" value="OS07G0242900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="22"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="659" mass="76948" checksum="126D97ADAB14D3F3" modified="2016-07-06" version="1">MFNVRNNNKNSVFLVALEAWFAFGSSNIPNEILTKIADYLSTKDRLSCALTCKEWRYPFQRVLWRNIRITTIEAAKRLVATIQESQRESISLGLSVQSLNIPIYCNMEGVQDTDILMYLPNLRHLDLGNVSYVDIYTKTTRSYSVWKSLESLKFVSNKREWIRPGKNLLEFVNTCCRLQELEISASPFNHRIEFSVNDFDVMHQNLRQLSSIKVDMYLNPDFSSALGKIPDTRPAFGVKSLNINSKKYVSRYEYTNQWNPLWLYYFGYKYPNVHTLKIDATETCHNPITSDQKQKIISLFQSNPNAFKHLETFHFANDRYFESSDFFLWDVLWALRVPLKHLDLDATVNQGADHSHTMDIDRILQSFSRTLETLSLKGFIYFESSLNPKLRLSSYYPLLTYLCISGHIVSIDLDDLLDRCVALKQLGFSGEELFVTPRTIDNKPKQHHALQILTLFECTTSAKVFRRLSFRCRKLRYMALGSLWITGSISKKTGRLFIDMPYTLLQDLHIDQVQYITSNQEFDITKAINMTHLTQLYDPILADELNERKRKEAADPKAPTMISHTICWVYTYGYFVTSRYHRQGTYELLEEEGDYAQQYFQDFKPKKTGIKLRDGSYFDEDEPETFWEYELFKGYGEFRFGKVADYITGGIYPPGNYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N3D4</accession>
    <name>A0A162N3D4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_150783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286158.1">
        <property type="nucleotide sequence ID" value="XM_018432546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N3D4"/>
    <dbReference type="GeneID" id="28993452"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150783"/>
    <dbReference type="InParanoid" id="A0A162N3D4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="293" mass="33340" checksum="805F75C7E4CD6A7B" modified="2016-07-06" version="1">MVYADVKRCLTSPLFSTPLFLEKRATNSFFPFAVKSGLRPEGDGSTLYTFWSQEFLFPAQVSRRVGCGCVRCGVETVDLENIRWLGMVYADVKRCLTSPLFSTPLFLEKRATNSFFPFAVKSGLRPEGDGSTLYTFWSQEFLFPAQVSRRVGCGCVRCGVETVDLENIRWLGMVYADVKRCLTSPLFSTPLFLEKRATNSFFPFAVKSGLRPEGDGSTLYTFWSQEFLCRLSGRFVLRRAYVSLFWTYKRECTNDLLYCVLRSLLTYLTGSFLRKCPDELGVAVCDAVWKPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N8M0</accession>
    <name>A0A162N8M0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-loop-helix DNA-binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_170012</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290158.1">
        <property type="nucleotide sequence ID" value="XM_018436230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N8M0"/>
    <dbReference type="STRING" id="763407.A0A162N8M0"/>
    <dbReference type="GeneID" id="28997136"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170012"/>
    <dbReference type="InParanoid" id="A0A162N8M0"/>
    <dbReference type="OrthoDB" id="5344169at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="477"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="341"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="526"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="536"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD72118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="621" mass="69197" checksum="FEECEEF3F735D25C" modified="2016-07-06" version="1">MDMSGFQLDGINDMDMLRSLSNRHSQDQDQSINMDESSSFDHFSKDIDLLFQTSHASAPTDLNSFLSPYQSTANTPQKLIITSTHMSPLYPHPHLSSNPVSQEFMDQDDIFTPLVSPAMTPSFTYQLPQKHHPNIPLTTEMDFSPLSSPAIMPQLDRQHSRDTSGNPIFGSQFSATFDKMSSTQICEQYEQLEQAKIMITRKLSELQQKQQQHLQQKQQQILQQQQQLQQQHQLQIQKQQQAQKKAQMQVVFSQTVQLPPSYTEATSPTTMAYTMQSFQPAVVPEKPSHLEPVTPASLMNMKMQSLSIPPKRLASTNQPPAFAPILTSQIEPVVALSHSLSDSSTQSLVLTPTDTPKTPPRSLSAKTTRGSTANSAGHKKISSTHASDAAPRPVSKKQRRESTLTHTDTKSLISPSPRALKPLLLSPTLTAGLESSPTRLNAERILATRSNYQNLMEGKAAALGIAFMPHIKSGIEVRRTAHKAAEQKRRDSLKEWFERLRREVEDGYVKKKSGLASIVIREQEREARGEIEDTSGGESSKTRQSSADEADHSEGADESDAVLKPLSKVLLLRYAYEYISTLKTSVSNRDLRILELEEENARLRQGSASKESSPPESPYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N9G0</accession>
    <name>A0A162N9G0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_65614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290378.1">
        <property type="nucleotide sequence ID" value="XM_018441496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N9G0"/>
    <dbReference type="STRING" id="763407.A0A162N9G0"/>
    <dbReference type="GeneID" id="29002402"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65614"/>
    <dbReference type="InParanoid" id="A0A162N9G0"/>
    <dbReference type="OrthoDB" id="2290147at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="112" mass="13037" checksum="8E6E470B0064D042" modified="2016-07-06" version="1">MTSPLFRHQYRGLYSDFDLQMKLWSFMLETWVGGSQKILLHCTGEVVKKATYLDESNIIEVKWPIIQIVGPNAYLCTMRLDAKQLYVLEEVYAFPFSNSLFEIRYGGINSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NAB4</accession>
    <name>A0A162NAB4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_169696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290608.1">
        <property type="nucleotide sequence ID" value="XM_018436135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NAB4"/>
    <dbReference type="GeneID" id="28997041"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169696"/>
    <dbReference type="InParanoid" id="A0A162NAB4"/>
    <dbReference type="OrthoDB" id="10419438at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="4"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="627" mass="72369" checksum="FFECE448C7000FA1" modified="2016-07-06" version="1">MLASDLPFEILVHIGKYLRLKHRLPCILVCQAWKTPFQESMWSKIRITDQKEINGICNIFDDKYITYERYGRHVRKLILDGEFRISNRQLFTLQQHFKGLKGLYMQKYCLSHVSFGSAADWTLWSTLRELKIRLDLIRVFDNEMELLKILSCLPRLENLGIDQGENPGSLVFTLEHFELLHQHLPQLRDASLALELDAISNDDLRRIRSTTPAKNLVTFNLSSDVKDNRWLCYFAQKYPNLSVFNWILIKNDNIQQSSNDAVSIFSGLPYAFPNLSAIQMYTEEDADLQHFLLWKLFRKFKVPLNNLKYTFSASHDSPELLPTIIHECTHSLSSTLTTLTIITAHQPAMTRDISAYFDYCIHLINLNLVVADAQVSIDVLLTQCPSLIRLRLSGVTLSVGSEGMKQQVQHKLRMLQIAYKTTTANTFNYISLHCRQLKYMNLTDVLVTGSISPETGSLCLSMPHTHFEILHMHGVRFCSSNNGAHHGVPVNFIVLSQPTAVLQKPKPTKLIKTFFSGKPTTKRSIQYTWFHIFSNDIKLENDAYLMRVLDNKEAKYAKNYFRQFRRNTSTISAKVERSYHGQLTMCNWKHDLSQGYVNLMCAYIGECSVGYKNMFSKTFWSELAENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NAH1</accession>
    <name>A0A162NAH1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_136959</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285374.1">
        <property type="nucleotide sequence ID" value="XM_018429822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NAH1"/>
    <dbReference type="STRING" id="763407.A0A162NAH1"/>
    <dbReference type="GeneID" id="28990728"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_136959"/>
    <dbReference type="InParanoid" id="A0A162NAH1"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD67334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="422" mass="45713" checksum="0C621D83DB27189F" modified="2016-07-06" version="1">MPDSQYSLVVAMLTAGGLIGALSASYFSDRYGRRQTLFGTNVLLGLGSLMMSLAVTPGSLMVGRFVAGLGSGVVTVVVPAYIAECVPKASRGFFGTLNQLAIVLGILVAQAVSMIWSTPSTWRFILLVGFILAVLQFCLLPWCVESPRLLFSKPNGWNRAKAALVRLRGVPDETIEEEIKTWRKEQAQEEDSLVSPAQPVTVYRFITLARYRYPLFLLLLIQLSQQLSGINAVIFYSTSIMSTVFPESSDKITLFISVVNLAMTLVSAYLMDRAGRRTLFLTSCGLMSSMSLLLGWSIETGHEITSACAIIGFVAAFAIGLGAIPFLMIPEIVEAPAVSSAASVALSVNMISNFAISAGFLQWRSVLGEGQVFYLFGGILIVLGFIAYCILPETKGRSAEEVVRSHWSIYAPAYQPIIGHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NDN2</accession>
    <name>A0A162NDN2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_150137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286584.1">
        <property type="nucleotide sequence ID" value="XM_018432410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NDN2"/>
    <dbReference type="STRING" id="763407.A0A162NDN2"/>
    <dbReference type="GeneID" id="28993316"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150137"/>
    <dbReference type="InParanoid" id="A0A162NDN2"/>
    <dbReference type="OrthoDB" id="5582742at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="25557" checksum="53930B07E4335BC6" modified="2016-07-06" version="1">MRFDCPDKILTDCGANFMFKIFLHYTNQIKVHHKFTSAFHLRTNSKSCRIHKHSTTGFSPFFLICSRTPRLPSDSLRPFMSADLSDNPQVFADDALSYLHNLWKAREDAEIWVFTNSLQGKKHWDAVMKPHSFAVGAYVLMRHKNKFGLEYNWMSPYVVVDKNSDTDVYKLTMTEGVSYTYWVHADHLKLAKDDDYTEFSFENDNQSDFLLLTKELEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NFW6</accession>
    <name>A0A162NFW6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_112159</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291898.1">
        <property type="nucleotide sequence ID" value="XM_018428265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NFW6"/>
    <dbReference type="FunCoup" id="A0A162NFW6">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NFW6"/>
    <dbReference type="GeneID" id="28989171"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_112159"/>
    <dbReference type="InParanoid" id="A0A162NFW6"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF132">
        <property type="entry name" value="POLYAMINE TRANSPORTER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="33"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD73858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="471" mass="52763" checksum="06993E28BE5F8DA9" modified="2016-07-06" version="1">MPDEKKVTVHYVNWEENDPENPNNWPARTRWMYTMLVASLVVSAAFSSSVVTGRLQGPMEDFGVSKEISILQVSLMVFGFMIGPLLWSPLSELYGRKPIYVCALFIYVIFNIPCAVAKNIETLLVCRFFSGFFASAGLTIAGGSISDLFHARERGNAIAYFAAAPYAGPVLGPIVGGWISVGTQSWRWIYWVNMMLAGVLWVLICLMPETYHPVLLARRAKRLRQETGDPSYVTVEEEFPTPLSELLRSNLIRPFEMIVTEPILLLMSMYISIIYALLYAFFFAYPIIFADIHHMNDGEVGVTFCGVLVGTFLALLVTPWLERVYQRSGEKNPTGEPTPENRLPGMMLAAPFIPVSLFIFGWTSFSWVHWFGPVSSGIPFGFGMVLVYYSANNYIIDCFPRYVTSALAAKTLVRSGTGAAFPLFIIQMYHGMGNQWASTLLAFISLAIVPIPYAFYFYGARIRARSKTATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NGV2</accession>
    <name>A0A162NGV2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_159763</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287494.1">
        <property type="nucleotide sequence ID" value="XM_018434055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NGV2"/>
    <dbReference type="FunCoup" id="A0A162NGV2">
        <property type="interactions" value="674"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NGV2"/>
    <dbReference type="GeneID" id="28994961"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159763"/>
    <dbReference type="InParanoid" id="A0A162NGV2"/>
    <dbReference type="OrthoDB" id="1049195at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12418">
        <property type="entry name" value="RRM_Aly_REF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF82">
        <property type="entry name" value="THO COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="15"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD69454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="170" mass="18695" checksum="3C8F9F41E00DAB78" modified="2016-07-06" version="1">MAVTRPAPAARGPRNNLVVSNLHPRVTEKDLYELFGQMGTVKRAFLHIGPTGRSAGIADIVFSQASDAERARITYNSVELDGRPMKISFATVVGSVVAQPTRQPLRNQDRRQNNNNNNNNTSYNNNGNGRRGGRGGLSKRRETRPKASEQDLDAQMDSYMAVPNEDIVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NJL6</accession>
    <name>A0A162NJL6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_148820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288314.1">
        <property type="nucleotide sequence ID" value="XM_018432167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NJL6"/>
    <dbReference type="GeneID" id="28993073"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148820"/>
    <dbReference type="InParanoid" id="A0A162NJL6"/>
    <dbReference type="OrthoDB" id="2286618at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="237" mass="27184" checksum="28B4297C29801B08" modified="2016-07-06" version="1">MQGVVLRQKNGTAFQDKYKAYWADRADADDTVTEVVKKHIFKMVAVTKIVEVNKSVHEINREISDEELLDIDNGGVLDISKGVIEEEKLAHLRGIGVIHPYQLETSCEPLVNAIEKIPPTTHADFNFVEVFGTHFPVNPHTSKKLERDVARHTSIIVLNNLFLADNDIIDLCWLERSTDHTDSKIFFEPLSLLDHHPYSKRTHCICYLLHHAKGATEVYLLDKHHVRLEVSRREFCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PFF4</accession>
    <name>A0A162PFF4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_176348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441013">
        <property type="protein sequence ID" value="OAD65186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283226.1">
        <property type="nucleotide sequence ID" value="XM_018437744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PFF4"/>
    <dbReference type="GeneID" id="28998650"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176348"/>
    <dbReference type="InParanoid" id="A0A162PFF4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="309" mass="35061" checksum="11F06D8D2A741E75" modified="2016-07-06" version="1">MAVVLRKWKHVTLFSAVLYPPRTIRPSMSGNHIEEHGKVRQIASLGSQNMRPRRYMSNTQKRVSVMEKGDFRLAGCTSGKKIGVEERPEMRESKIYTSSYNCICDMCRRFITMEYNPIAEQVNFIIVKYDTDQRNNNNEISSMLYYLAIVYRTLLTVGKSYKELNIGQWPLPPREGGTKAPKLFFPGYTYDSYSSSSYDSNSNSSYHSTSNSSYDSNSNFIYDSTSNSSYDSNSNSSYDSNSNFIYDSTSNSSYDSNFNSSYDSNSNSSYDSTSNSSYDSNFNSSYDSNSNSSYDSTSNSSYHSTSNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PLM4</accession>
    <name>A0A162PLM4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_148642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288116.1">
        <property type="nucleotide sequence ID" value="XM_018432124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PLM4"/>
    <dbReference type="GeneID" id="28993030"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148642"/>
    <dbReference type="InParanoid" id="A0A162PLM4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="87" mass="10463" checksum="FD1D5BD582F36C78" modified="2016-07-06" version="1">MSDLESDDKREEKELDSFSEKSFFWRFRPSWRSEEGDRFVDELDADYEAAHNKKNNTCPFEHKFKGIRDKQLSKTKANKLPSWSKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PUR4</accession>
    <name>A0A162PUR4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cleft lip and palate transmembrane 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_123461</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294217.1">
        <property type="nucleotide sequence ID" value="XM_018428930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PUR4"/>
    <dbReference type="STRING" id="763407.A0A162PUR4"/>
    <dbReference type="GeneID" id="28989836"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_123461"/>
    <dbReference type="InParanoid" id="A0A162PUR4"/>
    <dbReference type="OrthoDB" id="378564at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF0">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="182"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD76177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="625" mass="71653" checksum="C3B1F742D903960B" modified="2016-07-06" version="1">MVVMWVLMQVFFGNRNSSTPEPAVPSTAQNPEAAYTTPANTDYFPILPPGVYHNPYPVDIPTNTLPSAVVPLWKEGTPMKLSVYVNESPYFIEYSAQPDWVSNEIHFGEAFEDSEYHMDIPATQFLQNNGTLYAHVFLVREGSPINPADASFIPDSVVYVRHTLTKYYPKKAVLKQKNLLQRTEDEEKEEKEEKEEKEEVNQESQEGSTLGGFGDSFLGNWTRRAPLVAYWHENVTLSLVNDPKSTIPKNGLQPATVKYIPFDTGLTRDSSGKVGFYRPIVFPNDFWVLRQNAYPINETISTLPLNIRFEPIAMWKFNIYAVFDDSMKQQSNNPLGGMSSSETDEMKRMFMETNPVLLGTTLIVSLLHSLFEFLAFKNDIAFWNKKNNSAGVSVRSIIVNIFFQIVIFLYLLDNNQETSWMVLIGQGVGLLIEVWKVFKALKYELVWVPGSLLPSLGTQNIESTETEDDTAKYDAIAFKYLIWLSYPLLGGYAIYSLMYDEHKSWYSFVLKTLVEFVYMFGFITMVPQLYINYRLKSVAHMPWRTLLYKSLNTFIDDLFAFVIKMPTLHRLACLRDDVVFFVYLYQRYAYKEDHTRANEFGQVGTEVSATITEGDSKDGETKKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PYP1</accession>
    <name>A0A162PYP1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_143767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293556.1">
        <property type="nucleotide sequence ID" value="XM_018431063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PYP1"/>
    <dbReference type="GeneID" id="28991969"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143767"/>
    <dbReference type="InParanoid" id="A0A162PYP1"/>
    <dbReference type="OrthoDB" id="2245819at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="150" mass="16689" checksum="B404B4C211083E06" modified="2016-07-06" version="1">MHPLHNAISPKLLSTIKHGYEHDEPPSHEHIANQELSFHTSVIDMTILASPMYSLGLQINPFASGSACGKNPYTENANTSYYPAVLTFSYVRKLVLPPMMITALPNSSQALCPSYWVALLTILWHFDKLCNSDGDYTHETHFGTLWAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q498</accession>
    <name>A0A162Q498_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extradiol ring-cleavage dioxygenase class III enzyme subunit B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_121541</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297966.1">
        <property type="nucleotide sequence ID" value="XM_018428810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q498"/>
    <dbReference type="FunCoup" id="A0A162Q498">
        <property type="interactions" value="345"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162Q498"/>
    <dbReference type="GeneID" id="28989716"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_121541"/>
    <dbReference type="InParanoid" id="A0A162Q498"/>
    <dbReference type="OrthoDB" id="7396853at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF0">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="12"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD79926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="292" mass="32571" checksum="1E4559406291E1D8" modified="2016-07-06" version="1">MTSVSTIKRAPVFFISHGGPTLLEDKGKPGEFYTWLGKYIKNVIKPKAIVVISAHWQGKGKSGISVDSSTKPELIYDFYGFPKHFYSETWDQLGEPELASRIVGMLKKSGIQATAERYGNDHGVWVPLKRAMRETGGIPIVEVSTFSHENMTMHISMGEALAPLRDENILIIGSGSAVHNLRLLWSYGDKPSPKYAIDFDRTMEKYACTLKGGERNKAASTLDQHPNFRDCHPTAEHLVPFHVALGAAGEDKGIKLLEDYFSTISWGCYGFGLPEDLRVPQYSNGFKYHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q8I2</accession>
    <name>A0A162Q8I2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_161619</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299026.1">
        <property type="nucleotide sequence ID" value="XM_018434436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q8I2"/>
    <dbReference type="STRING" id="763407.A0A162Q8I2"/>
    <dbReference type="GeneID" id="28995342"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161619"/>
    <dbReference type="InParanoid" id="A0A162Q8I2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47823">
        <property type="entry name" value="lambda integrase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD80986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="249" mass="28472" checksum="D13090084AEFE758" modified="2016-07-06" version="1">MNSNSSNHPAETPDIYARMIEAQASTSREAEANRPDNTKRSYASKQKEFREWCDEAFSSVLPEYRYTVVNRTSRRNTGKSIKYSTAISADAFVETDVEPTEVLLQRAMPLLYKKLEDTQNEFNALRREMLTEFRAIQQKMDDLVSGRTSLRFFREDEGERAGIRPMSTPSLPSPAINTESSSQQPAEYFNGFVSFIATAIVIFYFVKLLYSIEHLSKEAYFIQSNSNILIIKIEGFSFIAILNISYLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q9Y9</accession>
    <name>A0A162Q9Y9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_70690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299346.1">
        <property type="nucleotide sequence ID" value="XM_018442318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q9Y9"/>
    <dbReference type="GeneID" id="29003224"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70690"/>
    <dbReference type="InParanoid" id="A0A162Q9Y9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="122" mass="14283" checksum="54AB2A4DA86977E0" modified="2016-07-06" version="1">METYPTFSIVIKQLCAFVIRSQTQAVMTATPLNIDEGTFSISNRPIVSMVQSYIHMQPEVEYVLSSVVEEKARRHLSYKIHRAKSLSEKLAGRNRFSRCRTRKIRIKKYFSKLKGRRNDQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T047</accession>
    <name>A0A162T047_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_153757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441014">
        <property type="protein sequence ID" value="OAD65162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283202.1">
        <property type="nucleotide sequence ID" value="XM_018433245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T047"/>
    <dbReference type="GeneID" id="28994151"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153757"/>
    <dbReference type="InParanoid" id="A0A162T047"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="228" mass="25453" checksum="E325BBB9F21E86E3" modified="2016-07-06" version="1">MGICTELLTSQSNPVKAIDSQANSPSKDFTSMFDNGLAEMIPVEMTWTPCLTMITMAVINTLINTRFLRSKLKSLTMKGQIVLIGFIYHVLKTYSRHFQPPARLSGFQKMPPFFLAIAKGIQRFVEDFLHSSTSVNKRELIYQSNTNALNVFFIHPDLEVKISVNIVSFKPSGGITYLFGATYLANNNLSYSKRLNPKNLILAGLIARPKKPKFSAINSHSNPFADGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T1K4</accession>
    <name>A0A162T1K4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_153425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441010">
        <property type="protein sequence ID" value="OAD65522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283562.1">
        <property type="nucleotide sequence ID" value="XM_018433145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T1K4"/>
    <dbReference type="GeneID" id="28994051"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153425"/>
    <dbReference type="InParanoid" id="A0A162T1K4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24614" checksum="B6344E87EC255269" modified="2016-07-06" version="1">MKKYPRFSIEIFAEKLWDWKFESDDPALVAENETVINYLKSYISTQTRLAGTHPWVISDKVKNRYKHSHCTFHESPEQKAKKNSKGRANSRTLQSTYMDNWVAIDAAMGYKTGNSVEKTYLKLFQKDAMSDGESDIEIVDNLPRRCLHVACPTWRSEEFNRLLTMVDDIDHTHHVSNAGVGTKPRMNRYLATLLPCSVPATLSQSLSRWAINNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T389</accession>
    <name>A0A162T389_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_102198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441007">
        <property type="protein sequence ID" value="OAD65932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283972.1">
        <property type="nucleotide sequence ID" value="XM_018427683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T389"/>
    <dbReference type="STRING" id="763407.A0A162T389"/>
    <dbReference type="GeneID" id="28988589"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_102198"/>
    <dbReference type="InParanoid" id="A0A162T389"/>
    <dbReference type="OrthoDB" id="3039677at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="178" mass="20388" checksum="874EA00F50176B88" modified="2016-07-06" version="1" fragment="single">NLPRNERYKPENTLLVGLMPGPKEPKSEEINHHLRPMVDDLIRLYEGLAIPTFECPSGVCVRAALMMVACDIPAARKTSRFTSHNSTCACYKCNRHFPCLENGVNVDFHGFDFSRWVLCDGVENRLHAEEWESASTPSERHWLEIENGVRWSQLHRLGYLDLVRGTIIDPMHNLFPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TBP4</accession>
    <name>A0A162TBP4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_63595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285442.1">
        <property type="nucleotide sequence ID" value="XM_018441144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TBP4"/>
    <dbReference type="STRING" id="763407.A0A162TBP4"/>
    <dbReference type="GeneID" id="29002050"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63595"/>
    <dbReference type="InParanoid" id="A0A162TBP4"/>
    <dbReference type="OrthoDB" id="2262863at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="292" mass="33795" checksum="256CAD1AD1793FFE" modified="2016-07-06" version="1">MQPGGPLYTRSTGLSRKFTQNLRHSGSFVSRDFKVLLQILPVILITEFSGNHELDLVTSDFDNYIIRVDNAVKCLIRALFDYDKGTKNELHKAYCTKLKVHYLTHLKENIIRFGPALNYETEKGKQFNKHICEHLFHTNRQNTSRDVCLKFAKQVALQHRFIKDNNKSLFYYTFFGGSRELKDNNDTRDIEDDAVQNNSFGAFVFKDDPISRPRIGLVSGSVVKFLSIVPRTDNVRNNNYAKAVMTGEHSDVANMNLVCKSDLHIFHNLFYIVNLSKFGSYWFIFNNILFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TDB4</accession>
    <name>A0A162TDB4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_26444</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285722.1">
        <property type="nucleotide sequence ID" value="XM_018439890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TDB4"/>
    <dbReference type="STRING" id="763407.A0A162TDB4"/>
    <dbReference type="GeneID" id="29000796"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_26444"/>
    <dbReference type="InParanoid" id="A0A162TDB4"/>
    <dbReference type="OrthoDB" id="1938621at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120510">
        <property type="term" value="C:mitochondrial [4Fe-4S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000006">
        <property type="entry name" value="Iron-sulfur cluster assembly 2 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="6">
        <location>
            <begin position="6"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD67682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="103" mass="11567" checksum="C720206AC172CC4A" modified="2016-07-06" version="1">MIADRDNDHDHFLRVMVESGGCHGYQNKMELTKTVDEDDIIFEKQGVRVVVDGVSLQFIRGSNVDFVEELIGSTFQVVDNPNAKHSCGCNISYDIDIDMLTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TEH8</accession>
    <name>A0A162TEH8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_175051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441002">
        <property type="protein sequence ID" value="OAD66503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284543.1">
        <property type="nucleotide sequence ID" value="XM_018437398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TEH8"/>
    <dbReference type="GeneID" id="28998304"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175051"/>
    <dbReference type="InParanoid" id="A0A162TEH8"/>
    <dbReference type="OrthoDB" id="2255950at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="550" mass="62668" checksum="32208218FCE20429" modified="2016-07-06" version="1">MLVTDLPFEIISLIIGYLSTKDRNQCSIVCQAWKLPSTEALWKQLNIRSKKQIRGLSSIQQSLPVQTLCLHPFLSINPQQLFWIQNHFPKLRSVCISPEALHPDCLDTTLADWTLWRSLTKLELCTDNLRVPKETILYTLSALSSLTSLSWIQSTDGTSSPPFGWKDLEALHTNLPRLVTLYLKARMDQLSAEQIQLISRSQSFSPARCLTCMTWEVNTLEPHWLIYWAYKYPNICSLQWLTIDHDTKFDSGTEIITLPETLPSSFQKLGNLTLEGVFYTHRPQHALFLLLHRSNVHLKSIQCSIYINQRGSQKIPSILNDIMQSSSSLQSLKLNIHGDVDDPNLLPSLFKTCPRLLVLSIRGMRMHLSLDRILDKCVSLESLYINVSRLHVEATAPAHSIQAIVLTAGFLNSSELTFLSKRCTELKTLGLVDLILRTDEATSHGQALSLDLSSLHLRTLCVKRVMFYKSNVGTDRPKLQRLALVLPQTSILNNDERPQRIPHCERMFFTDNTFCETTLKTRIIKTCFLPKPIAGCVTAKVRYDRKDMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162THN6</accession>
    <name>A0A162THN6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_173082</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286702.1">
        <property type="nucleotide sequence ID" value="XM_018436937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162THN6"/>
    <dbReference type="GeneID" id="28997843"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_173082"/>
    <dbReference type="InParanoid" id="A0A162THN6"/>
    <dbReference type="OrthoDB" id="2273964at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007839835" description="Extracellular membrane protein CFEM domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD68662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22039" checksum="F6D1C5F469E9EEF8" modified="2016-07-06" version="1">MKLAFLMVNLFLIARLSCACETNAMFRLCMKTGKAAVDACESNSMTSCGCSAQKQLLACYTECGDSYDMFAQEEGQLRYVKEACDFLGAEIESQNRVDGESGLTKQSQGGTDRRWRAASVNSTSENGNFGMSPIHLDEPRLANSHAEAAAAAVAMNPNLNYKGNRDLEDNIEKNPKASTASLSAYPVMCVSLLSGIVLVFTLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TJ94</accession>
    <name>A0A162TJ94_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase subunit 4, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytochrome c oxidase polypeptide IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">COX5B</name>
        <name evidence="12" type="ORF">PHYBLDRAFT_116781</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 5B family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD69032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287072.1">
        <property type="nucleotide sequence ID" value="XM_018428540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TJ94"/>
    <dbReference type="FunCoup" id="A0A162TJ94">
        <property type="interactions" value="314"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TJ94"/>
    <dbReference type="GeneID" id="28989446"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_116781"/>
    <dbReference type="InParanoid" id="A0A162TJ94"/>
    <dbReference type="OrthoDB" id="10249250at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00924">
        <property type="entry name" value="Cyt_c_Oxidase_Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.11.10:FF:000003">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.11.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002124">
        <property type="entry name" value="Cyt_c_oxidase_su5b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036972">
        <property type="entry name" value="Cyt_c_oxidase_su5b_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01215">
        <property type="entry name" value="COX5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57802">
        <property type="entry name" value="Rubredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51359">
        <property type="entry name" value="COX5B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602124-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD69032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="106" mass="11783" checksum="9623056CCA306EEF" modified="2016-07-06" version="1" fragment="single">GGKAGEVPTDLEQATGLERIELLAKLEGKELFDMEPLQVTHLGTPKNPIVVESHDPIRFVGCTGFPVESHDVIWINLDKSHEHDRCPECGSVFTMNFVGSEDEHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TJF4</accession>
    <name>A0A162TJF4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_173945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285653.1">
        <property type="nucleotide sequence ID" value="XM_018437145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TJF4"/>
    <dbReference type="GeneID" id="28998051"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_173945"/>
    <dbReference type="InParanoid" id="A0A162TJF4"/>
    <dbReference type="OrthoDB" id="2260752at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="787" mass="87873" checksum="00EF936D63743F93" modified="2016-07-06" version="1">MSSQHSAANSLPREEQSPLTEVGIPSPVLNEQTHLTEIGDISPLLGSTALSIDGDIEMIYTSLDSLPPLSVVGSVPPTPVPTVPSAINSNTSSSITLEMLLASAKEDLSIKKNNFYVAYANYVALSKVNPMSDAARHASSIKKEAQELFEDAQKTLKVLEKANAPPAILEDKKSMVVPSNLPFLQLCTETRVKQNRDVFDSVYDFCQEFTMVLESHSLSLDSCWERLLPICLNKEERSWFEDKLKGKAYKRFLNMGRVWKMMQKKGESVRAFGAKFQTARRQASLEDGIQMVLCFWWNLRPEVREASLIPLSANYGTKLPSKVEDIISLVSVATSDSTALLNQPAESGTPAKWKSFSDAHSISSSISHKGKKRAIARDNDPKHAKKSWNFKKAIKDNVCFSCKGAWEKGHTCPERDNYLTKVSRMAVRSPADRSVASSPACGGFPPSRDSHFSVRGNSSPVGSSSTSWLMDQDNTSALAKMALNCKDNHKDMIIKKDFKNMSTNITFSILANNSIRTIALLDCGATFSSVDKNFCLQNKISINYVNHINKDLVNNSNVHKYFIRLADSNTHIKRIGTCVISITCNSKTIQREFEVMNLTNSYEYDFSIGTDYMSTLGIGIYGLPLSYDDADSSKERREADRCFNNKSDLLESIERENEQKENNPAVGPKQFEDAMDYICPFIKDNQDIPKGSFCTIPESVVCLDTPENATAFRSPYPIPYKMQGVVDEQEYWQRIGEAPESIKDINKANKRLLKDMKVVNSIPKEKSGIKRKNYAKTALQKKKRSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TKL9</accession>
    <name>A0A162TKL9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4Fe-4S Mo/W bis-MGD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_149727</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287372.1">
        <property type="nucleotide sequence ID" value="XM_018432325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TKL9"/>
    <dbReference type="GeneID" id="28993231"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149727"/>
    <dbReference type="InParanoid" id="A0A162TKL9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="5">
        <location>
            <begin position="85"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD69332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="131" mass="14349" checksum="B8368CD5D6C371E7" modified="2016-07-06" version="1">MPKWFRDLWGTKRQECGRHALKYSHKAHYFHDHFKTGCVFDVGSDADTDASTKANTNTTISTSTNNSNPGPVSRATTELLSCTDIRYTKTQCGTQCWGPCLVNSGVNISGRIGIVQPTSQPTSQPANQPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TNW4</accession>
    <name>A0A162TNW4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_188619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286673.1">
        <property type="nucleotide sequence ID" value="XM_018439537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TNW4"/>
    <dbReference type="STRING" id="763407.A0A162TNW4"/>
    <dbReference type="GeneID" id="29000443"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_188619"/>
    <dbReference type="InParanoid" id="A0A162TNW4"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323:SF0">
        <property type="entry name" value="CALCIUM HOMEOSTASIS ENDOPLASMIC RETICULUM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323">
        <property type="entry name" value="SR-RELATED CTD ASSOCIATED FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="11"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD68633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="383" mass="42091" checksum="ED6A2D3F6EF0ECAB" modified="2016-07-06" version="1" fragment="single">MMPPMPHEQVMVAEKHEALRSTLADLGNDKMIKALDDLRMILQMIMQDCSRANIEAGKTWSFEYCCHPARAEALIDFILALSLSKPTFEERLHLLYLINDVLFHCIRRQLPWMKELILHRLVPLLRTVYHCPGANEMTKAKVNKVMTIWGDKNFFAPNIIHSIRENVYIPPPPHMPVLGPPPGMPGMMPGFRPPFVPPGAIGPMGMPPMEGSNPAKMPTQMPPHLGVPPRPHPSRGMGVGVGGGSYLPPTSAISTPIPTPGLGPGPGLGLGLGSIPTSGKSSNPTTAPAPPPIPASPPKRYYELPAGWMVTAHKNTAEPYTPIDPVAIQQHHQQSQKNPSIANYLKAPLEDFYDGLDLNDHSDTFEENTDGRVDRNGWEPDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TQH7</accession>
    <name>A0A162TQH7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tryptophan synthase beta chain-like PALP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_136102</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287033.1">
        <property type="nucleotide sequence ID" value="XM_018429764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TQH7"/>
    <dbReference type="FunCoup" id="A0A162TQH7">
        <property type="interactions" value="162"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TQH7"/>
    <dbReference type="GeneID" id="28990670"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_136102"/>
    <dbReference type="InParanoid" id="A0A162TQH7"/>
    <dbReference type="OrthoDB" id="271064at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030378">
        <property type="term" value="F:serine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018114">
        <property type="term" value="F:threonine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070179">
        <property type="term" value="P:D-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000005">
        <property type="entry name" value="Threonine dehydratase catabolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050">
        <property type="entry name" value="SERINE / THREONINE RACEMASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050:SF1">
        <property type="entry name" value="SERINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="9">
        <location>
            <begin position="17"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD68993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="327" mass="34773" checksum="B96D33F7C2ADBB8D" modified="2016-07-06" version="1">MSVTFGDVEAAWARINVTRTPVHTCATFDALASHTTPVELFFKCELFQKTGSFKFRGASNAVAMLSDEEAINGVVAHSTGNHAQAIALAAKARNIPAYVVMPHNVPEIKKIAVRGYGGTVVECNPPQKAREKAASDIQASTGAVLIHPFENPRVMAGQGTIAYEFLEQVDLDALIVPVGGGGMISGCAVAAKGIKPTIKVFGAEPAAVDKCSRSYNSKTHQTSLPGSTSVADGLLTTLGVNAFPILLSSVDGVFTVTEEEIVRAMKLVWTRMKLMIEPSSAVGVAVALYNNEFQERVKKDKLGRIGIVLGGGNVDPARAIELFERYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TSH8</accession>
    <name>A0A162TSH8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_171428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288722.1">
        <property type="nucleotide sequence ID" value="XM_018436594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TSH8"/>
    <dbReference type="STRING" id="763407.A0A162TSH8"/>
    <dbReference type="GeneID" id="28997500"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171428"/>
    <dbReference type="InParanoid" id="A0A162TSH8"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="8"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD70682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="122" mass="14462" checksum="AA59714C540D77C1" modified="2016-07-06" version="1">MDKFREKLTSIHAELDTATKRADDLDEKVKLLEEEHEQKDNQVTELQNRVKVLEEQLEKAEDDLKDTTKNYREADLRVEQLDKKAVKLEQEIKIWDKKCDDIEEKYLASKAEMDELEGQLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TTN2</accession>
    <name>A0A162TTN2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="3 9">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_172347</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="3 9"/>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287753.1">
        <property type="nucleotide sequence ID" value="XM_018436775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TTN2"/>
    <dbReference type="FunCoup" id="A0A162TTN2">
        <property type="interactions" value="428"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TTN2"/>
    <dbReference type="GeneID" id="28997681"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172347"/>
    <dbReference type="InParanoid" id="A0A162TTN2"/>
    <dbReference type="OrthoDB" id="60984at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000018">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 9" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="6 9" id="KW-0521">NADP</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="10">
        <location>
            <begin position="23"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="208"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD69713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="508" mass="58513" checksum="A5AF5168F54F5B2B" modified="2016-07-06" version="1">MTSTIAGIKEDLKREMQGGVTVVVLGASGDLATKKSFPCLYGLYKRDLLPEKVHIIGYARSKFSREQFVKKITQHIKTDSEEDKKKLDEFLKFTEYISGAYDKEEAFKDLDKNISDWEQKNKLKKGQKNRLFYMALPPSVFLSVASGLHNSTRTTEGKNRLVIEKPFGKDLESYKKLNSDLAPLFDEKEEVFRIDHYLGKEMIKDITTLRFANMLFSPLWSGYHIKSVQITLKENFGTEGRGGYFDEYGIIRDVMQNHLLQLMSVLAMERPIRRDANAIRDEKVKLLRSVKPIKMEDCLLGQYTAANDKPGYLDDETVPKGSTCPTFAALAFYINNERWDNVPFIMRAGKAMETSKVEVRIQFKALPGILFEDAPHNELVIRVQPNEAIYIKFNNKSPGFSDDCLLTELDLTYKNRYSNLQIPDAYESLLLDAMRGDRANFVRDDELEASWEIFTPLLHRIEKDKIVPEKYPYGTRGPAKLSKFMDRYGVVHTPHNQYQWPIQDVAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U3R6</accession>
    <name>A0A162U3R6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T4 RNA ligase 1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_80047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290183.1">
        <property type="nucleotide sequence ID" value="XM_018443544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U3R6"/>
    <dbReference type="STRING" id="763407.A0A162U3R6"/>
    <dbReference type="GeneID" id="29004449"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_80047"/>
    <dbReference type="InParanoid" id="A0A162U3R6"/>
    <dbReference type="OrthoDB" id="276239at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019039">
        <property type="entry name" value="T4-Rnl1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004:SF1">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09511">
        <property type="entry name" value="RNA_lig_T4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T4 RNA ligase 1-like N-terminal" evidence="1">
        <location>
            <begin position="86"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="384" mass="45047" checksum="3A0683C8980D9495" modified="2016-07-06" version="1">MTHLIYSISPAWSAKFNYWFISVILHLKCNSIQSIEIDNYKETNEVVAPAANQRVVNYTTRDQTIWTSWRIEEKIYKSHRDPLPSKARGLFTVHEDGVHRVVVRGYDKFFNVGETDDTQWDAFREGTEGPYDVTLKENGCIILISALSESSLAVTSKHALPKVQDDEYSHAGVGYKWLCKHLASVHMTERDLAEWIYHKDITLVAELCDDEFEEHVLEYEPANRGLYLHGINYNTMEYHTVPMDAVRQVAVVFGFFPPEYISLQNIQGVEDMSQEMQRTHKFLGREVEGVVVRCKKGGKDFQFKIKDRQYLQYREYREVTNIILSAKDKKKDAKNVWKRYEKTSDYIDWLESLIQTDPDRLKDYRKKKGIISMRKDFEKEIKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UCL5</accession>
    <name>A0A162UCL5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_186695</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NXF family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292153.1">
        <property type="nucleotide sequence ID" value="XM_018439270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UCL5"/>
    <dbReference type="FunCoup" id="A0A162UCL5">
        <property type="interactions" value="338"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UCL5"/>
    <dbReference type="GeneID" id="29000176"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_186695"/>
    <dbReference type="InParanoid" id="A0A162UCL5"/>
    <dbReference type="OrthoDB" id="25872at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057125">
        <property type="entry name" value="NXF1/2/3/5-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24048">
        <property type="entry name" value="LRR_NXF1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22602">
        <property type="entry name" value="NXF_NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="7">
        <location>
            <begin position="441"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD74113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="638" mass="70588" checksum="C877B39D6A43B52D" modified="2016-07-06" version="1">MATNPISTPKPASKGLAGMFGFPVKSDNNPITDGAPIVFNIPSTTFIKPGDSMDVSNGSSGGGSWKTIKRSAKPEKSLTSKVRAAGKNAIISVAGEAQKPIVPKATIIEKDEDISMGFGSSGSKSKRRFTPYGNRKSKKNADAKMELAPEKRVDVLVAGYEPNTETSLIPFLKKRSKKIWDPINALFDQGQMLLTVEDANIAHSIVRLNGYSFGKGQLQIRLFKDPPPSEATPFGTPEGPTKDTKLTTIDSMRLFLRSRWDAENRFLNLDNMAADPILKKAAIRPPGVRGSNEFVGPALIKLAGEMFEDINALSLADNKLVDVRQISTLTQFLPTLKKLSFKDNQIKTYEAIKPLSGSGKLEQLEELLLVGNPLRESELKQRGNLRSYMINMIKLFPSLHMLDLETVDLTVDEAAAVLKKANILPIRVAPSFFEDEHTRATTFAFLERYLSLFDTDRLALRPFYNGSSMFSMVTNLKIQKEQKVRRKDKKKMMDDDFATVTWASMNRNLLLSKNSKTPGSKLISGQEEIVHTLARLPNTIHDLSSSEDFVVDAVQTPYGLMVSVHGEFKQDSAGVILYSFDRNFLLGPSADMSTGLPFTILSDMLCVRDHAGNKCANDKSFKYSNVIVRYQSLTQPLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UHZ0</accession>
    <name>A0A162UHZ0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription activator GCR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_59880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294382.1">
        <property type="nucleotide sequence ID" value="XM_018440572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UHZ0"/>
    <dbReference type="STRING" id="763407.A0A162UHZ0"/>
    <dbReference type="GeneID" id="29001478"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_59880"/>
    <dbReference type="InParanoid" id="A0A162UHZ0"/>
    <dbReference type="OrthoDB" id="2287578at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060963">
        <property type="term" value="P:positive regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052146">
        <property type="entry name" value="HOT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022210">
        <property type="entry name" value="TF_GCR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37784">
        <property type="entry name" value="PROTEIN MSN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37784:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR-LIKE PROTEIN EUC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12550">
        <property type="entry name" value="GCR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription activator GCR1-like" evidence="2">
        <location>
            <begin position="122"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD76342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="250" mass="28236" checksum="3CDC22A646D22161" modified="2016-07-06" version="1">MYKNVGSDLQTRTVGTREDDLAMMRFRAAAPVLYQTFENLQAQIRSESNNMKDLLNQAITNLADISANRAPITINISALSFTMSSGTESGGSGNIQTTQFANTPSQPQEQQGQSTALPPLKYRMNRGVKSVPELWREWHFGLNGGKSVVEMERLQPGWHNQDNTFFARRRRVVTTIKKYARENGLSEEAAMHLAEGRRVLGRKTIDFLGKIKTAYLKTNKSDNKYVSFDEYMSLNSSVLAAPYYFIYTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UMA3</accession>
    <name>A0A162UMA3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_166284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294353.1">
        <property type="nucleotide sequence ID" value="XM_018435396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UMA3"/>
    <dbReference type="GeneID" id="28996302"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166284"/>
    <dbReference type="InParanoid" id="A0A162UMA3"/>
    <dbReference type="OrthoDB" id="5596236at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="119" mass="14301" checksum="E4AB125DA4C47849" modified="2016-07-06" version="1">MSMRAILTTKLYLMHIFFCQFFSDCFLLSTLLIQTSPFRCTNLNCLENLDGSEVMHRLWNRDLAAVLNFRHILNNLRYDGTIPVRFTRVIRIGRIRRQAEEDLQEGRRLRQRLTRIQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UWT6</accession>
    <name>A0A162UWT6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_62755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296522.1">
        <property type="nucleotide sequence ID" value="XM_018441010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UWT6"/>
    <dbReference type="FunCoup" id="A0A162UWT6">
        <property type="interactions" value="424"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UWT6"/>
    <dbReference type="GeneID" id="29001916"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_62755"/>
    <dbReference type="InParanoid" id="A0A162UWT6"/>
    <dbReference type="OrthoDB" id="308449at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051959">
        <property type="entry name" value="PAK1-Kinase_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675:SF1">
        <property type="entry name" value="P21-ACTIVATED PROTEIN KINASE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675">
        <property type="entry name" value="PAK1 INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="134"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="174"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="256"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD78482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="388" mass="43372" checksum="225158D053960774" modified="2016-07-06" version="1">MASIEATKKRSRGEDNEETMDKPALKKQLLEGKSALDLILPISSITKELSDEDFRIITGTYERILYGINAYWENADDDSSSKPSLKLEPIFIVPAHTGCIRTVAIGGHFLASGSADEIIRLYDVKKRKEYGSLGGHHQGDVTDIKFHGKYMFSTSDDGTICLWRTKDWEFLKTLKGHKGRINSLAIHPSGRIALSVSSDRTVILWNLMSAKKASMTKLYRDEGLVVLWNTDGTKYAIMFDRKINVYNVSDAQVMTTIEHKSKFLCMRYFESSDKKEYIISGHEDKTIRIWEAETGKCVVEIVGHKFRIKTMETVKSKPSSESEPVTVLITASSDGVIKCWDVEAAIAAAESPEDITPLGEYNTKSRITCCTVHSGYAKTTGEVTVSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UX94</accession>
    <name>A0A162UX94_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="6">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_107209</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="6"/>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296622.1">
        <property type="nucleotide sequence ID" value="XM_018427985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UX94"/>
    <dbReference type="STRING" id="763407.A0A162UX94"/>
    <dbReference type="GeneID" id="28988891"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_107209"/>
    <dbReference type="InParanoid" id="A0A162UX94"/>
    <dbReference type="OrthoDB" id="59470at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000002">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF1">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ERV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD78582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="134" mass="14752" checksum="4AB1033C17B7A8C4" modified="2016-07-06" version="1">MDLAASEDAAKGGVIMSHLGNATIKAELGRSTWKLLHTMVARFPESPTSDERAALKQFILLLSRLYPCGECAEHFQKLLAKYPPQTSSRVAASQWACAIHNHVNQRLGKEIFNCADIEAKYQCGCDAENTETTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UYS9</accession>
    <name>A0A162UYS9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_140913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296902.1">
        <property type="nucleotide sequence ID" value="XM_018430481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UYS9"/>
    <dbReference type="STRING" id="763407.A0A162UYS9"/>
    <dbReference type="GeneID" id="28991387"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_140913"/>
    <dbReference type="InParanoid" id="A0A162UYS9"/>
    <dbReference type="OrthoDB" id="2596771at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="433" mass="50537" checksum="167F85E0FD539594" modified="2016-07-06" version="1">MSTVNITPMNENIYTLATISEALECSSIPGVMTLRLNNTIRTICNSNKRRTDITAEEAKNSGIKMCFSQKYSCHCSGTYESKTEMRVVQKRAKKNKCPALLCVREFFKTPEWYEITLTKDHADHTPEQSSKSASQIRIDMLRTIDRYGRSSDCKVNYYNIWNLMNKNQMISFMIWINEKLAAMNFSIFKTNTSYSPSLNLFTCGFMSPIQQNKMKNAVSFCLDATYGISGKIDEILYTLLIHNEEIGRGWPVAYMITNDRDVGPIVQWLQFLTSSLLLVNPKQITIDCCLAKVHAIQTTFFTTQIQFCIFHITQAWNRKLSDSVKISGSLLSEARLLHDKMMKSLQEIKNWCTENKFKLWSRAYFECQFSHMFTNNYIESWHNQLKTVFMKRFRNKRLDKLIFIFVHNVEYYLSQKYDRVMSNNEAMSAFTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UZ09</accession>
    <name>A0A162UZ09_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_164001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296943.1">
        <property type="nucleotide sequence ID" value="XM_018434916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UZ09"/>
    <dbReference type="STRING" id="763407.A0A162UZ09"/>
    <dbReference type="GeneID" id="28995822"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164001"/>
    <dbReference type="InParanoid" id="A0A162UZ09"/>
    <dbReference type="OrthoDB" id="2537141at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="540" mass="62350" checksum="86138CF56327CA51" modified="2016-07-06" version="1">MSLTKGNLEKLAFENMEAFKRYNTGLYIKQQKEIQDQSSRIKGRSGKSLSYILLLAYFVNRIIFRAMSLPDIPLNRHHNTRFKHTRKLGEHDEFSMVDKHKGKETPLKDTTTTATTTATGTQNQNQIHPTVTQINPKVKRTFKPTNTKNSISHESALRLLQAFSSSNIKTTRITQKPKENTQLGLFNKGKSSAKGVLRKKSDLVFSEHEFLHPRYHVRYTSNQSVISEEASDQDRSSFMTQSHQQQQQQQQQQQETVSRFFRTRSDKSDQSSVESDTFKIRQPQNQGHQQDHHLHQLYQQKQIQDDEEEDEEEENQKDISTKIVPELQDRYIGALYQSPDTSFGKKQDRWTNEKPDQSSETNTWCEKTTLSEDSHTFDGSTEAIERLLNECQAVPLPDFCNTPELHQSFRPTKWPECGADQDQSLYYSDRPWEIRSGVHTIPENNDCRSTIFSQCDIQEILSDCTGMTDLTNLWGCEDSGSVCSTTTTTTKNSKIDSSALGSTNTTDTSHHLEAVNYFWKRRIIIVREIKRNFIAKNREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V3Q0</accession>
    <name>A0A162V3Q0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_74277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297792.1">
        <property type="nucleotide sequence ID" value="XM_018443007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V3Q0"/>
    <dbReference type="FunCoup" id="A0A162V3Q0">
        <property type="interactions" value="380"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162V3Q0"/>
    <dbReference type="GeneID" id="29003913"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_74277"/>
    <dbReference type="InParanoid" id="A0A162V3Q0"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19076">
        <property type="entry name" value="AKR_AKR13A_13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD79752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="331" mass="36856" checksum="A77ECCBB4A730DD2" modified="2016-07-06" version="1">MVQLKEIGKTGVKVPAIGFGCMSLSGPYGSADDEESIKTLERSIELGSTFWDTANVYGIKSHNERLLSRVLKTQRDKIFLATKFGFIRDESGAISRFDGSPEHVREAFDKSQKNLGVDVVDLYYMHRVDPKVPIEDSVRAMAELVKEGRVRFLGLSECSAETLRRAHKVHPITAVQMEYSPWTLNIENNGILATARELGISIVAYSPLGRGFMTGSIRSLDDFDKDDFRRGLPRFSPENFDKNLKLVDDITALATKKGVTPGQYVLAWILAQGPEFFVIPGTRRVKNLEENVKAGDVVLTSEEVAEMRELIDKANIIGERYAPAQLATVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V639</accession>
    <name>A0A162V639_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_140246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298282.1">
        <property type="nucleotide sequence ID" value="XM_018430363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V639"/>
    <dbReference type="STRING" id="763407.A0A162V639"/>
    <dbReference type="GeneID" id="28991269"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_140246"/>
    <dbReference type="InParanoid" id="A0A162V639"/>
    <dbReference type="OrthoDB" id="2596771at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33977">
        <property type="entry name" value="ZINC ION BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33977:SF1">
        <property type="entry name" value="ZINC ION BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="1">
        <location>
            <begin position="258"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="451" mass="52260" checksum="51D0C907267428BF" modified="2016-07-06" version="1">MLREQQALRKAALEAAPVRTLRDIGSALGPSTISNVMKLKSNIWIISHPNRHSSAVDITKKKCVLFSQVYSCHRGGSYEPESREKHPIQRKSKKVSCKATLTITCYADKSHVYVFDFIANHTNHIPGDIKTDLGLIPLTRGRVDDIVARLTASPGSSARKIRLEILCDIDQQEYSLNRRKINYFDIYNKILAINQTIFHLHKDDFKSMKMWFTEKLSPKGFIIFEGNLQTYSNDESLYACRFTLPFQQIKIKAAAKFCMDATYSITQKSNDILYTIVIRDEELDRGFPCAYMLTNDHSLGPIIQWLKHLKVNQLVVNPQQFTTDCSDAETNALMAIFPGCQIQYCLFHVSQAWYRQLNLKVKTGNTAAQNRLVQGEMLTFLKHIMYEEHIVVFLDKIADFIGRYQQSQPDFVRYFETNWYTMAKYCVWSRAFHQLEFSHMLTNNYIKSWHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WHF5</accession>
    <name>A0A162WHF5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_174518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441025">
        <property type="protein sequence ID" value="OAD67135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285175.1">
        <property type="nucleotide sequence ID" value="XM_018437273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WHF5"/>
    <dbReference type="GeneID" id="28998179"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174518"/>
    <dbReference type="InParanoid" id="A0A162WHF5"/>
    <dbReference type="OrthoDB" id="2287304at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006912">
        <property type="entry name" value="Harbinger_derived_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47150:SF5">
        <property type="entry name" value="OS07G0546750 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47150">
        <property type="entry name" value="OS12G0169200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04827">
        <property type="entry name" value="Plant_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="176" mass="20646" checksum="548D9BD888F97E87" modified="2016-07-06" version="1">MNKSFATIILKEENLKTATIILEAVASYNLWIGHVFFGLPDSLNNINILNQSFLFKDLADRQGPEIEYRVNGNKYMMRYYLTDSIYPSYTAFIKSFNDHQTAKKKGVNREVVIKDRLEIESVLAEVPRLIPRSEILFPNRTFASCLQRNIRIWDQKQHFSLRQNVIDSLWKIEGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WJ52</accession>
    <name>A0A162WJ52_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">STAT transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_151393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285525.1">
        <property type="nucleotide sequence ID" value="XM_018432676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WJ52"/>
    <dbReference type="GeneID" id="28993582"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151393"/>
    <dbReference type="InParanoid" id="A0A162WJ52"/>
    <dbReference type="OrthoDB" id="10405035at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="314"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="643" mass="73934" checksum="A1D9672E4C46052E" modified="2016-07-06" version="1">MEKKTPALDVWTSIGTYFSGFSPTNQAKFIETMGRVSKSTYTKKEVETIIVSCTKLEADNCQLKHENERLRENINDLENDIKKSSTQANLIARTQQKKIDDLNETHKNNELRIESYMIMERKYNALLEDLSATKTELARIKPELDKYKDLKDRHRRILVQVNEANKKIEAFQSMEEHYKIISKKLPIANGQIALLNSEKKDLNSMVYQLSAARPYLYNCKVLEDIVTSISEQINKETMSEATWKKFDVYGYTVDSHSLSTKRQEKIIFLSSQLTIARDHLVKTKELESKIETLVQKMSVSQGALSIPKGTEDKVTFLLRQLADAEKRIDEKESLQEELESLRDKYTLKDMELFKAQNSYVKQTKQSDITNKAQTRKINYFQQRLEEVESDFTKRKKFLNPKDEEVNAFFFRHFGEGLPGIKALCTKKPDGKRGFSSGVINLLVEKIIINNLLRDICHMPSYFGVPSAIEYPKLSDYTPEKQTPEFSSQFRRNFENLLKDPKTSDALRKRREKVASVLVKLLHELFPAMNPYVTRKKMMEIVEAAAELSLSIHTQDLAVNIVKLIEGKDQLRTYTKTQLGSSAGAKTIQIVICPPFIANEGQKTEHVLLEGKVICLEIVTDSNEASAENYSDSDSEPMENRMYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162X9G6</accession>
    <name>A0A162X9G6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_112724</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291415.1">
        <property type="nucleotide sequence ID" value="XM_018428306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162X9G6"/>
    <dbReference type="STRING" id="763407.A0A162X9G6"/>
    <dbReference type="GeneID" id="28989212"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_112724"/>
    <dbReference type="InParanoid" id="A0A162X9G6"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000705">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="44"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD73375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="319" mass="35913" checksum="A6758519EBA0AD62" modified="2016-07-06" version="1">MDTVSTEVRLKRREQKRQKEMAKDAEVIADLKAICTDADPTKLYRNMIKIGQGASGGVCIAQSVDTNMSVAIKQMCLDKQPKKELIINEILVMRDARHKNIVNFIDSFLVHGELWVVMEYMEGGSLTDVVTTNMMTESQIATVCKETLEGICHLHNLDIIHRDIKSDNVLLGLNGQVKLTDFGFCARLSDSELRTTLVGTPYWMAPEVVTRKEYGPKIDVWSLGIMAIEMIEGEPPYLHENALRALYLIATNGTPHLQHPDALSDNLTDFLRLSLTVDSQNRPSASELLEHPFLRKAEHVRSLIPLIKASRDLRKAHEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XE68</accession>
    <name>A0A162XE68_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_71467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292305.1">
        <property type="nucleotide sequence ID" value="XM_018442475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XE68"/>
    <dbReference type="GeneID" id="29003381"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71467"/>
    <dbReference type="InParanoid" id="A0A162XE68"/>
    <dbReference type="OrthoDB" id="10310698at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007840972" evidence="1">
        <location>
            <begin position="21"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="136" mass="15060" checksum="4D36C781E1B14E02" modified="2016-07-06" version="1">MKAFIFFALLVATSIGSIMAAPSSDKVDDPTKDLPKIDCIQVTYPTNGVVWTTGTVYNITWNVLFDCVYPKSVYLGKDVNNQFEFDYLVNSNLNITAGLAYITLPDDIEKVFHAIVIGTTEYGRVRINSKIGILVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y6W9</accession>
    <name>A0A162Y6W9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_185294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296705.1">
        <property type="nucleotide sequence ID" value="XM_018439056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y6W9"/>
    <dbReference type="STRING" id="763407.A0A162Y6W9"/>
    <dbReference type="GeneID" id="28999962"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_185294"/>
    <dbReference type="InParanoid" id="A0A162Y6W9"/>
    <dbReference type="OrthoDB" id="2289236at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF18">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="527"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD78665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="843" mass="93172" checksum="07B4F685EF80477F" modified="2016-07-06" version="1">MQSACLGQINNRLFSVNYNKKDDTTNPTTTVQSYDIADTSNPAQSTNTVNLLTTANDEIYEPVCAFDPSRSEFYVLGKNADKVSQVVNVFNVAADGLSLGYSWQIRLGNTIKDKIVSVVPFDFQDASQCVALLDINGSIYSTCRNLNGLVSRFPYQSIGSSIDTTRLARISNQGGTAGYNILQFGYTASTIIEFNTSNARSNTTSSIAVSYHKLATDLSNPVQAYEITKDSRNLLILSKNSIELFYVNVPVGQATQLVSANPDAQPTIFGSPVGVPTQLPNVTTISSLSDRKTRTPTPTSKKPSNSVNNETEEYTDRPEPTIISLLTSLASQEKRKIKRRAKRDVTPAPQASASSDPSNLVPNRVGLPSSLNDWNSISIFRSIPGVDDNSGTLLIGGYNGEGQFSVLSEAIGSLEYPYSPPGSAGSNGPTGPSSKAGPIAGGVVGGVLALALLIFLFMWCRRKNRRRKHSTVSTRSPVMEELPTTLFHNKTKYNEDRSLYIRMDIPYGMLERYEPDALNGASILDPYVLSNDTFDGSINENRIPNYATRTCMDSKNGTREHPKLYTIHYFTTANYSAFVQSIRVAKALASSPHAVKHIIAFDIQTPTANYGYRYYWVSSLCTASQTLLRMLTHDPNRDSFYEDFVSDFDFKTWSTLSILSALADMHTHRYVHLGLSLESFVYQAADSITDWRVCCFDQSLEAGTYNSTGVVLNSMSAPELFKNAILRENGHYKVSRLQANPAVDLWSVGCIIYQLAARRPLFKDSTEANKILQQDEEQINAWLTKAFLHISSSSHTDGKRLADAFVPLLVRLLVVDPAHRVSAREISESWREEYQLNEDHDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YDF6</accession>
    <name>A0A162YDF6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_121656</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1. Interacts with NUBP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298085.1">
        <property type="nucleotide sequence ID" value="XM_018428821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YDF6"/>
    <dbReference type="STRING" id="763407.A0A162YDF6"/>
    <dbReference type="GeneID" id="28989727"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_121656"/>
    <dbReference type="InParanoid" id="A0A162YDF6"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000796">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03039">
        <property type="entry name" value="NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028600">
        <property type="entry name" value="NUBP2/Cfd1_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="18"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD80045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="267" mass="29004" checksum="69515A83DDFEE505" modified="2016-07-06" version="1">MSEINLSNIKHIVLILSGKGGVGKSSVTTQLALGLVQKGFKVGVLDIDLTGPSIPRMLGLDGKQVHQASQGWVPVYADEQQRLSCMSIGFLLSSKNDSVVWRGPKKNAMIKQFLQDVYWGELDYLLIDTPPGTSDEHISIVEYLKSFEPDGAVIVTTPQNVAIADVRKEISFCRKVKLPILGVVENMSGFVCPHCADCTNIFSSGGGESMANEYGIDFFGRVPIDPGFTSMVEAEGDGSYVKSFSKSNLFPVFQEICDKVITKTSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZFP5</accession>
    <name>A0A162ZFP5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_183886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441003">
        <property type="protein sequence ID" value="OAD66471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284511.1">
        <property type="nucleotide sequence ID" value="XM_018438851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZFP5"/>
    <dbReference type="STRING" id="763407.A0A162ZFP5"/>
    <dbReference type="GeneID" id="28999757"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_183886"/>
    <dbReference type="InParanoid" id="A0A162ZFP5"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="37"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="309" mass="34507" checksum="6015223217C5E81E" modified="2016-07-06" version="1">MTFDSSLLNREFLVPALEYLPLKCYLSGSPSQCSPLIILFHGTGGDHFQFDSLLPTLVQHKYCVLTIDLPYHGLSQPVAFSNPESPVTFESILENLDEVMKAYRCANPSSQNPIDLIIGGVSMGGMLAQICCDQRKTAWEEIGFSFRLLVPIGCSSTSLLWPRMEWMDYLGVMADDSPEKKSTIDNMRVAIVMSAIKPENQNEASRAMELVHDQTLFLYLRACGRAMPPIPSSHSDGFQFKDKPVCIPHLLMRGDNDLLTEIYMAGWITWIQEHNIDSSLKIVSNAGHLANLDNGVEMAEEIIKAAKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZIJ5</accession>
    <name>A0A162ZIJ5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_137132</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD67031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285071.1">
        <property type="nucleotide sequence ID" value="XM_018429837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZIJ5"/>
    <dbReference type="FunCoup" id="A0A162ZIJ5">
        <property type="interactions" value="222"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162ZIJ5"/>
    <dbReference type="GeneID" id="28990743"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_137132"/>
    <dbReference type="InParanoid" id="A0A162ZIJ5"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00951">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00952">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD67031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="214" mass="25159" checksum="24E76C81B3DE12AC" modified="2016-07-06" version="1">MNLFRFVADLMHLASVVILLLKIRSTRSCVGISFKSQLLYTVVFLTRYLDLATKYISLYNTCMKIFFIGTSFYVLYLMKFRFKATYDAGLDTFRIWYLLVPCAILAGLSTREYSVLETLWTFSLWLESVAILPQLFMLQRTGEAETITTHYLFALGAYRALYLFNWIYRYVTEAHIEWVALVAGLLQTALYSDFFYIYYTKVMRGKKFELPKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZQQ6</accession>
    <name>A0A162ZQQ6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_156385</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286471.1">
        <property type="nucleotide sequence ID" value="XM_018433485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZQQ6"/>
    <dbReference type="FunCoup" id="A0A162ZQQ6">
        <property type="interactions" value="487"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162ZQQ6"/>
    <dbReference type="GeneID" id="28994391"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_156385"/>
    <dbReference type="InParanoid" id="A0A162ZQQ6"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000055">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000009">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="53"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD68431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="407" mass="46279" checksum="5C6E687A0ACDB318" modified="2016-07-06" version="1">MNHNETTASFNHSGMSTSNFSHFKLSGDSNDILRTVRVPAKDGKTGLDIQLQYTNQKVIGNGSFGVVYQAKLVHTGEDCAIKKVLQDRRFKNRELQIMRLMDHPNVCALKAYFYTQGDAKDEVYLNLVMEYVPETVHRVSRHYAKIKQPVPMLIVKLYMYQLFRSLAYSHTLGICHRDIKPQNLLVNPVTGVLKLCDFGSAKILVSGEPNVAYICSRYYRAPELIFGATSYKTSIDIWSAGCVMGELLLGQPLFPGESGIDQLVEIIKVLGTPSKEQIATMNPHYTDHKFPQIKPHPLSKVFRSRTPPEAIDLLSRILQYEPETRLTASEALVHPFFDELRNPDTKMATGRELPLLFNFTHEELSVRPDLIHSLVPSYCQEELRFRNIDVHQFTPVPLEKMRLASLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163A6M2</accession>
    <name>A0A163A6M2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_170797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289471.1">
        <property type="nucleotide sequence ID" value="XM_018436430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163A6M2"/>
    <dbReference type="GeneID" id="28997336"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170797"/>
    <dbReference type="InParanoid" id="A0A163A6M2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="293" mass="33351" checksum="68C322461E6A0A01" modified="2016-07-06" version="1">MCNSKMSCPLRHYFLLKVVKRKEDFICGVGQIKLGQEVLGEDFLVDSEIREASNLLHSASARTITNAASVTRSTDSAVIQLIQNMHETLIAVLKGQEQILMEIADIKNDLNKRESTEQEDEASIPSIDPIRRPVSNIKDITMRHIHKMISQDLGIEVTKVEKSKLHTCTLLICDQLAALPSVQALGPRPKWGSIPKRDKKMICARHASMLKANGIDFTRCHGNWASIAKVGQLWKDRQKREINNTPSITKYLWICFKPSTSLVTEFNWSFCDLTRQKTEKRELLTESWFLVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AHH7</accession>
    <name>A0A163AHH7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_63785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291561.1">
        <property type="nucleotide sequence ID" value="XM_018441181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AHH7"/>
    <dbReference type="GeneID" id="29002087"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63785"/>
    <dbReference type="InParanoid" id="A0A163AHH7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="104" mass="11570" checksum="02CBC8E796087CEC" modified="2016-07-06" version="1">MINPALAVFHSDMAGALSNILQELTTYQPGLSLDQCFEFGEALFNRFLSHLTKSQGAAFVQEVLNELRMLIGYLKTFRARAASLLGLYSSIPLELGEDVVNRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B445</accession>
    <name>A0A163B445_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_179461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296221.1">
        <property type="nucleotide sequence ID" value="XM_018438149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B445"/>
    <dbReference type="GeneID" id="28999055"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179461"/>
    <dbReference type="InParanoid" id="A0A163B445"/>
    <dbReference type="OrthoDB" id="2277039at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD78181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="157" mass="17645" checksum="D934FE86DC79D2D3" modified="2016-07-06" version="1">MDKPNLHSRGGPPNDYDWPVTILMYVLMTLLGLGMCFCLRKANRLIPNRLSFPLVSTQPKDIAGNRRGRGYDASDVEQGDTDAHQGLLSEYQQDSNDEYEEGDNQDDGFPRPPLRGVTIAGHNNDNNDDDSASFDEEFGELQAAEDEWQKNNEPRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B8Z4</accession>
    <name>A0A163B8Z4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_163974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296921.1">
        <property type="nucleotide sequence ID" value="XM_018434914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B8Z4"/>
    <dbReference type="GeneID" id="28995820"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_163974"/>
    <dbReference type="InParanoid" id="A0A163B8Z4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="159" mass="18483" checksum="EDF09C11C2F50D2A" modified="2016-07-06" version="1">MAYLENLNNAPNFSRVSIQILRKTVLEIINFSGLLARRDQCLAMAFISLKCTEITMGDPHSINNISPHKKQILEKNDSIYIKSTLYFALLVCRRFISMEYNPITEQVIFIIVKYDTEQRSNNNEISSIVSSSRFYLDFYPVFRLLAKSHVPRIHFILSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163CX45</accession>
    <name>A0A163CX45_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_152564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441004">
        <property type="protein sequence ID" value="OAD66240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284280.1">
        <property type="nucleotide sequence ID" value="XM_018432950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163CX45"/>
    <dbReference type="GeneID" id="28993856"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152564"/>
    <dbReference type="InParanoid" id="A0A163CX45"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="214" mass="23942" checksum="A988B027B184ED9D" modified="2016-07-06" version="1">MVSVKFKELVSRTTIQAKELFIALVTSIDAVVCSEVASLSRYGDITYHHVSRQELIDELDQDDSAFVDHLSGKQTLPPDIDIAVALKGKDKTRMRSHERKELKCAFFRVKAPQLKPPLTCTADTLDFAFTLLHFLLVFPQTLLCLSAATEFPVRAFQVPELSRDSNPLFPVGLFRIPLTPRTTGQLLVKECHHQIFTASICSSRQCTYFAAQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163CXA9</accession>
    <name>A0A163CXA9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_71135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441004">
        <property type="protein sequence ID" value="OAD66280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284320.1">
        <property type="nucleotide sequence ID" value="XM_018442413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163CXA9"/>
    <dbReference type="STRING" id="763407.A0A163CXA9"/>
    <dbReference type="GeneID" id="29003319"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71135"/>
    <dbReference type="InParanoid" id="A0A163CXA9"/>
    <dbReference type="OrthoDB" id="2448307at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF2">
        <property type="entry name" value="TRP C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="319" mass="37291" checksum="DDB57B6087964264" modified="2016-07-06" version="1">MFSFRKRLSERIDQNKWTKRFLLLVGIQLLFTIPNLIATAVMYNPYNYEYLNTPEGGDDKWYDTIAKRARIQYESIWFIIFEIWRFWLAVDGVLHGNSMTISVTFFSTAFAIVLGAMQIVECTKVIEYTRLSVVPQIIMTSLLCAVAVPTLYATYKMYRHSDWIKFHKLGPDVSLHVMYHWVQCFVLVIKGDMFFQAMALCLYFAVLAFSYERWYPFIIVLAPIVTIAFLYLGRRGTTIFLTIKCQTQFGKGLRDYVQMRGTKNKSFNSKQDTETRLDTEYILSGWNDVENNQEHNNTVISNNVNNNNIFESLRTGNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163D4D9</accession>
    <name>A0A163D4D9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome biogenesis protein BMS1/TSR1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_160077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286680.1">
        <property type="nucleotide sequence ID" value="XM_018434111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163D4D9"/>
    <dbReference type="STRING" id="763407.A0A163D4D9"/>
    <dbReference type="GeneID" id="28995017"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160077"/>
    <dbReference type="InParanoid" id="A0A163D4D9"/>
    <dbReference type="OrthoDB" id="119302at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome biogenesis protein BMS1/TSR1 C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="160" mass="18227" checksum="46F68079A9F5CA3C" modified="2016-07-06" version="1">MGKPSVATVYGPVVFGKVPCMFYKETEDVNEPILVSTGMFMNTDVKRIVAKRIVLSGHPFKVNKKSAVVRYMFFNPEDVHWFKPVQLQTKYGRVGHIRESLGTHGYMKCIFDGPLTQQDTVMMPLYKRIYPKWNTAIWTGGLDKTIKEAGESKAMVIDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163D4Z6</accession>
    <name>A0A163D4Z6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_150373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286820.1">
        <property type="nucleotide sequence ID" value="XM_018432463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163D4Z6"/>
    <dbReference type="GeneID" id="28993369"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150373"/>
    <dbReference type="InParanoid" id="A0A163D4Z6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="223" mass="24986" checksum="3DE6D5F3C59AD43B" modified="2016-07-06" version="1">MNNTDNTVIQLLQGIQAALISLKSGQEALLGRQEALEKRQDVMQLQRTSFYNEFKDWEFTDRTIVTSTSTVTGIIPRPVSKINDITLKHIYKMITDNLGIELTKKTKRIVNTCTKVICDQLAALPSVQDLGTNPGWSLLPQEDKNRLCINHSIILRDNGIDFTRCHRNWASIARVSQLWRGRKKREYSGGILGGLLGGSFGKTSKKTIPIFGNIIRSPLTDGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DFH0</accession>
    <name>A0A163DFH0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_89718</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288920.1">
        <property type="nucleotide sequence ID" value="XM_018443731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DFH0"/>
    <dbReference type="FunCoup" id="A0A163DFH0">
        <property type="interactions" value="243"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163DFH0"/>
    <dbReference type="GeneID" id="29004636"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_89718"/>
    <dbReference type="InParanoid" id="A0A163DFH0"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000003">
        <property type="entry name" value="4-hydroxybenzoate polyprenyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD70880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="296" mass="31998" checksum="1E728234B59DEACE" modified="2016-07-06" version="1" fragment="single">NWIDRLPPKVAPYIYLLRLDKPIGTWLLFWPCAWSITLAASATNASVTQTGAMLALFGAGALTMRGAGCVINDLWDRDIDDKAGSIFIYVERTKVRPIASGAISPAKAIAFLGCQLSVGLAVLTQLNCIFLGASSLSLVVSYPLMKRVTYWPQTVLGLAYNWGALLGWSAMTGSLDLAAIGPLYVGGVAWTLVYDTIYAHQDKADDVKIGVKSTALRFGDKTTEWLTGFSSVFVSMTALSGYMCGQGLPFYLLSVGGVATHLAWQLKTVNYNDPADCWNKFKSNTWTGGLLWSGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DJ74</accession>
    <name>A0A163DJ74_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_170270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289650.1">
        <property type="nucleotide sequence ID" value="XM_018436302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DJ74"/>
    <dbReference type="GeneID" id="28997208"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170270"/>
    <dbReference type="InParanoid" id="A0A163DJ74"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="110" mass="12532" checksum="2DCE3421CC35A156" modified="2016-07-06" version="1">MILVINTCYALYNLCIDNSASIAMNAEEEAEICVYLESDTNGRAELSVHSLSVDQFSTARSFNARLRHFKEQRIIKRNEVMNSFVCLSNLYPDESSSRSIVLQERFGKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DYA7</accession>
    <name>A0A163DYA7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_63888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292200.1">
        <property type="nucleotide sequence ID" value="XM_018441198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DYA7"/>
    <dbReference type="STRING" id="763407.A0A163DYA7"/>
    <dbReference type="GeneID" id="29002104"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63888"/>
    <dbReference type="InParanoid" id="A0A163DYA7"/>
    <dbReference type="OrthoDB" id="9970274at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025886">
        <property type="entry name" value="PP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31960:SF26">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31960">
        <property type="entry name" value="F-BOX PROTEIN PP2-A15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14299">
        <property type="entry name" value="PP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012565594" evidence="1">
        <location>
            <begin position="16"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="199" mass="23095" checksum="EDC600803A1C2A32" modified="2016-07-06" version="1">MLICIALLRISAVNDMCIIHMDSHYWEPIKTESSIYGHVARLNFVCWLSIFGNFESVPSGTYKIQWRIRVTKSIINHGMFKFRVSLKSFPEESPVTDETRLMPRKFYTDPSIVRRGWLVLTIPGTIGIDKKLGFSKVYIVHNDISSSWKSGLEIDWARLVPVSHAKDYDDAKLYVKMNQDNHMYSVHKDSDLGNIYKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JDW7</accession>
    <name>A0A167JDW7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_175759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441027">
        <property type="protein sequence ID" value="OAD65797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283837.1">
        <property type="nucleotide sequence ID" value="XM_018437567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JDW7"/>
    <dbReference type="GeneID" id="28998473"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175759"/>
    <dbReference type="InParanoid" id="A0A167JDW7"/>
    <dbReference type="OrthoDB" id="2263388at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD65797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="298" mass="33905" checksum="236D424CFE06B050" modified="2016-07-06" version="1">MSSSNASQQRDRISTQQYQCDQCVLFFDNYQKLQNHKRIHREDSATMTEIDQSILDDVDMYHDENDTSNEDESVRNSEYTMESMDLDNIISYKCACNFEDSEGEAHIYDSSRISTNTFIKAKLMSIHLSQLMLQHRIARAAYRDIVQFINTVIRDYDDIMMEPGAKISHGETVDALLKSKSSVKSHEYDVCSSGCRLYGINDNQESCVDCGKPQYKTDPNQSQTSAASMKLMSVGDMLSQMLADPATRKLLCYRANWESVAGQLTDIFDGDNYKQLMQQGLFSNPDNIAIGLYTVVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JE96</accession>
    <name>A0A167JE96_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_88373</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441027">
        <property type="protein sequence ID" value="OAD65818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283858.1">
        <property type="nucleotide sequence ID" value="XM_018443691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JE96"/>
    <dbReference type="FunCoup" id="A0A167JE96">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167JE96"/>
    <dbReference type="GeneID" id="29004596"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_88373"/>
    <dbReference type="InParanoid" id="A0A167JE96"/>
    <dbReference type="OrthoDB" id="354826at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000354">
        <property type="entry name" value="AGC/YANK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000210">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF30">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 32B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="10">
        <location>
            <begin position="283"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="327"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="333"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD65818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="42692" checksum="04940440DE7C4FD9" modified="2016-07-06" version="1" fragment="single">MGALCCKQDPLDLGGEVDLSHFVLLRSVGKGAFGKVRVVQHKGTKQLFALKYINKTKCIGMRAVDNIISERRLLEKISYGLTVNMRYAFQDDENLFMVLDLMLGGDLRFHLDRLGTIPEASVQFYAAQVALSLNYLHSKRIIHRDLKPDNILLNENGHAHITDFNIAVRFQESKPLTSIAGSMAYMAPEILQKRGYFAAVDWWSLGVVCFELLFGKAIRPFRGKTNEALQNAIMYDPLRFPENHSISSHAIEFLKALMTRDPNSRLGYNEQGFARFKAHPWMQGMRWELLEHKQAVPPFVPDRKRANFDPTHELEEILLEENPLKVRKRSPKRSGSNINMSLKSHTSDANLPEMSPEWQRMEEKFLPFDFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JQH9</accession>
    <name>A0A167JQH9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_137246</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441002">
        <property type="protein sequence ID" value="OAD66506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284546.1">
        <property type="nucleotide sequence ID" value="XM_018429847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JQH9"/>
    <dbReference type="FunCoup" id="A0A167JQH9">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167JQH9"/>
    <dbReference type="GeneID" id="28990753"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_137246"/>
    <dbReference type="InParanoid" id="A0A167JQH9"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD66506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="162" mass="17960" checksum="9F8451E97EF31A00" modified="2016-07-06" version="1">MANQQELIDDVIYCARYGELEELKETKPSPELLVKGDESGNTALHMASANNHVQIVAWILDQLLLTGTPLAPLVNVRNKEGNTPLHWAALNGHTEIVELLVKAGADCKTKNEAGKTPIYEAQQHNHEKVAEFFLLTMMEEEPEEPMDEDEECVETGVPEQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K4I4</accession>
    <name>A0A167K4I4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_151520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285307.1">
        <property type="nucleotide sequence ID" value="XM_018432697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K4I4"/>
    <dbReference type="STRING" id="763407.A0A167K4I4"/>
    <dbReference type="GeneID" id="28993603"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151520"/>
    <dbReference type="InParanoid" id="A0A167K4I4"/>
    <dbReference type="OrthoDB" id="2379842at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22744">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="868"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="793"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="887"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="908" mass="101730" checksum="427AC38F92056EC8" modified="2016-07-06" version="1">MSCKEKWAGYLTNKLKHFDCVTTQHVESGHHALKRSISALQSLDSSFEQICSYLLQFEGDYQDRRLDEKLVTDARILADERLCGLVHLVSRMPLFTIRAELLEEVIIGEACYCRVKTMFGLPCHHTLPQNRALTLPDIPERWVLSSVLPFHNKEVEKLEREQQICNLMAKVNDLINNAGNLKDHLEVAFPLSSEVKAPERSKHVKRKTALLKDFVRHKHRHLLVQKNKSEIRKILKEGIIDVMKELLEKKPLKKTIKNIKKETQFAEKQEPLKEAEKYSSGIKRPNHLPDDYWYDIPSPKKQKKNVHDFALPDQIDQTAILLTFNPKSDGWCGFRVFAHLKEGGEDQFPLVKKKMLATMTTHSELYEQNFGMDIAEVTKVIAFGPDIDPAIDNQSILPITFLPLHNRKLLKRKLLPMVLHHVHGCHWTTIKVKPHVHRSWPEFPKNKSYLLPSTTITNSLTNSPYKVCAFISNLIKIFIHMALPAKVLDPPIGSTTTLGQANITTPQPSTTTSTTTNTRSYLNVATATPAPGQVPVILFSNLPTSTDRVWRESTSRHSVFFTPPTDSTLTSEFWTALRASVPTACTLGISFAHRQPLIHELHLTNSTICTKLCSKGFLVGGQTYFPSMGIAPGTKILRISLSQLPYLPSPLLEEAIKTALAAYGTVREVGLYLRVNFFDGTGSAYLERPPNPNATLAKLSYKIPYDGDLYFLGTWKQMGIHCNYCKTGHLQHACPRAPPTDASSSKRPRKVPTTHDSPDRSCKTTPGVSHRPLAKKSIPPRGTPTMAEGSQATTTTSSTNSSTPRRPSVPAVPTSPRQSANRFAALDGLTDNSRTGALFDPTLPLPQTHNTQYDPVFHPLHNAFLPSNYTSGSTKDEEEFHPSTFDGNDDQDSQNILTDDEMADGDHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K5S2</accession>
    <name>A0A167K5S2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_174376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285376.1">
        <property type="nucleotide sequence ID" value="XM_018437240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K5S2"/>
    <dbReference type="GeneID" id="28998146"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174376"/>
    <dbReference type="InParanoid" id="A0A167K5S2"/>
    <dbReference type="OrthoDB" id="2272687at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="168" mass="18893" checksum="92DEDD00F0D1AAF3" modified="2016-07-06" version="1">MSSRLSRLSRQAVHGLVNSICTPLPKYQESLKTIKKNGYEILGYARKSPTGEDAPSRTRLLKSMVSNLKERSFATKIFVLPSSWASSTLASRDLKDNSRAIVDELRVAGNTNLKFENIVFKVQNKVRSEPAIEYIDDTMNYNYLIDIVLGEEVEEFLQALSNVCPCIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K5V7</accession>
    <name>A0A167K5V7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit</fullName>
            <ecNumber evidence="3">2.4.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GlcNAc-PI synthesis protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_128198</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.198" evidence="3"/>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285378.1">
        <property type="nucleotide sequence ID" value="XM_018429209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K5V7"/>
    <dbReference type="FunCoup" id="A0A167K5V7">
        <property type="interactions" value="255"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167K5V7"/>
    <dbReference type="GeneID" id="28990115"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_128198"/>
    <dbReference type="InParanoid" id="A0A167K5V7"/>
    <dbReference type="OrthoDB" id="734129at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03796">
        <property type="entry name" value="GT4_PIG-A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000026">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039507">
        <property type="entry name" value="PIG-A/GPI3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="10">
        <location>
            <begin position="36"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="9">
        <location>
            <begin position="184"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD67338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="440" mass="49799" checksum="DF1D2015AD01FDC9" modified="2016-07-06" version="1">MVSDFFYPNMGGVESHLYLLSQCLILRGHKVIIITHAYGNRTGVRYLTNGLKVYYVPTLVIHNEATLPTIYGFFPLFRNILIRESINIVHGHGAFSSLCHEGILHSKTMGLKACFTDHSLFGFADASSILTNKLLKFTLSDIDHVICVSHTSKENTVLRAALSPRNVSVIPNAVVASQFQPDPSAADPNWITIVVISRQVYRKGMDLLVAVIPRICSMYHNVRFIIGGDGPKRIDLEQMREKHLLHDRVELLGPVKHHQVRNILIQGNIFLNTSLTEAFCIAIVEAACAGLLVVSTKVGGVPEVLPSHMINYAMPEEDDLMIAVSKAIQMIKIGEVDPSRFNDELKDMYSWSNVAERTEKVYDSISQSQPSPLIERLRRYYGCGLYAGKIFCMVMALDYLFWRFLEFVFPKDSIERAQPFPYKRYRDYVDKVEEPKAQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KA67</accession>
    <name>A0A167KA67_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_174269</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285619.1">
        <property type="nucleotide sequence ID" value="XM_018437218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KA67"/>
    <dbReference type="STRING" id="763407.A0A167KA67"/>
    <dbReference type="GeneID" id="28998124"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174269"/>
    <dbReference type="InParanoid" id="A0A167KA67"/>
    <dbReference type="OrthoDB" id="5971719at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF7">
        <property type="entry name" value="NOSTRIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="605"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="280"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="361"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="466"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="492"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="540"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="570"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD67579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="670" mass="75580" checksum="303C0198F779DA97" modified="2016-07-06" version="1">MDLNMDNCISQITFGQENDQINGTTVLTNRMRDAKHSCELLKHIYEARASIEQEYGQRMMQMAQDIRVPDEETGGVRDIIDAVQQGLESTAENKLQLSEAIRSNLVLPLSNLIQGQKSIKAQTDSTIQKSLSARQLHTRERYNSECLRANKELQKCTAKERKSHYMRSNTVINNLYKDHEDSMTHLETAVNNWNTEWRFGCEIFEQLEEERIEFFRENLAQYYTLLLENCETKESFDISRQNVLDINVDKELDQFVKDHRSTSTIPNMIDYISFSAATATTDDTDTDTNPQQDVTRQRFEQTTEHTPRRDPDPRPSKSVLKNKTPEIKQNIRSSQPSKLSQPPQEAPRAMLAHMKIYDWEESDEDQDSDEYQESDIENDNGSDSYSSHDREIARTIAQASKDECHDNHLVTSSPLPMTSSAEPSVDPILDMPSVDANFDDSPRSSSSRVNDELEDMLQQLEKQKKVSSIGSAKGASITSSRYPPRQRPTKNTTTTTTAASGTASAISATKINHLQRNESGRSTSSMESSASDDLFDPVSRKSTAPTLSSVGSGNPLGTSRNTLADLDMNVNPNRQQSPSTGQSRNDLESWRSESMSPSNTGTELTFVDYAIARFDYAAKDEDEISFTKGDLLGIIDKNEDGWWLSRRWEEASGWSEQGCAPNNYLTLVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KV92</accession>
    <name>A0A167KV92_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Poly(A) RNA polymerase mitochondrial-like central palm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_67066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287007.1">
        <property type="nucleotide sequence ID" value="XM_018441734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KV92"/>
    <dbReference type="STRING" id="763407.A0A167KV92"/>
    <dbReference type="GeneID" id="29002640"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_67066"/>
    <dbReference type="InParanoid" id="A0A167KV92"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="2">
        <location>
            <begin position="203"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD68967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="363" mass="42630" checksum="FBE715A218D86368" modified="2016-07-06" version="1">MSIYTRNEKPDKNQILELCKEFTWSQSLVSPTDRHNISSPQVALVSEMASYIRQSKGVHYRDIDAHGWLVDFLNDYKHEEYLVPTSRFSRWNYMLIPENEYFHRKNNPNQHHHHQQQQQQQQQLPLITYSLNPKKNDFLFVMFPPTTSGDRVHRSLPQTNRSNNCNFNTYYPSVSSSVSSSYQEGQDNLSIELYDFLKASKRMKVQNQRSNILRKISMMLQDVWPEKKLRLEVFGSSVNGLDFENSDLDLCIVVPKEDYKKDLYNMSRLMNEPFSVYNMRFVESKLRDIGMLNVKAITAATVPICKFNDPVSNICCDINTNNILGIDNSKLVKAYSFLDTRVRPFLYAIKYFVKCRDINECKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KX02</accession>
    <name>A0A167KX02_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_22169</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD69077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287117.1">
        <property type="nucleotide sequence ID" value="XM_018439777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KX02"/>
    <dbReference type="FunCoup" id="A0A167KX02">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167KX02"/>
    <dbReference type="GeneID" id="29000683"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_22169"/>
    <dbReference type="InParanoid" id="A0A167KX02"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000044">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="11"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="600"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="606"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD69077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="642" mass="73062" checksum="47D18ACD3B581AFB" modified="2016-07-06" version="1">MSDAKYFQRGKIQELRAELNSEKRDPKHQRKKTVMKKIVANMTMGNDMSLLFPDILNVMNVPILEIKKMVYLYLINYARSKPDMAMMAITMFIKDVEDPNPLIRALAIRTMGYIQVEKIVDCLVDPLRHCLRDRDPYVRKTAAICVAKLYMYDNVLVESEHFIDMLRELLTDPNPTVVANAVAALTEISERSENTQLKLNHSIANKLAAALNECSEWGQTYILEALMYYVPQEAGDAEMLAERIAPRLQHANSAVVLTCVKVMMYLMNYMKNEADVNAFCRKLSPPLVTLLSSGPEVQYVALRNILLVIQRRPEVLRNDMKVFFCKYNDPIYVKLAKLEIIFRLANAQSVDQVLSELTEYAAEVDVDFVRKAVRSIGRLAVKIESAAERCITALLDLIHTKVNYVVQEAIVVIRDIFRKYPNQYESIIGTLCENLDNLDEPEAKAAMIWIIGQYADRIENADVLLDDFLYTFLEEPVEVQMALLTATVKLFIKRPTAGQDLVPKVLKWATEEAVNPDLRDRGYIYWRLLSTDPAAAKAIVLSDKPSISTESDNMDPAFLNELLLHISSLASIYHKSPTTFISHYKPRFLIPSPALQLPDSPSTFSLQPLQPQQPQQPQQTQMRMQQPGSFNDLGYNNVAANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KXG1</accession>
    <name>A0A167KXG1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_172939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD69109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287149.1">
        <property type="nucleotide sequence ID" value="XM_018436896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KXG1"/>
    <dbReference type="GeneID" id="28997802"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172939"/>
    <dbReference type="InParanoid" id="A0A167KXG1"/>
    <dbReference type="OrthoDB" id="2431110at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD69109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="652" mass="74244" checksum="C248B1141CCF979E" modified="2016-07-06" version="1">MMADNVSVDNEISEVNGNDSDIERDMNSDSGSGEEEGVKTDVEEFVNEDPFDAPNMPENPVHQFITTFAILFISRYVVNKGAAILIEFINQLLKIYGKDFQLPTSLIGLQRMTGFSNYANGIKKSVVCEDCHKVYEQDVPLPTHCDFKKHGSQSACNCELMKVSSSGAMIAKRSYIYNSIQRSLQLHRLGYFDLVRGTIIDPMHNLFLGTPKRMMEWWIKEGLIDDRKLATMQTMAETMVVPMDYVVLKSKIGKGFPYIKAGEWKSWVLVYSPILLKAVLPIEMFRNWISFVDACRQLVKPSITFSDIDDGHKFLQEFCTECQRIYTPTILTCNMHLHLHLHETIRDFGPVYGYWLFGFEQYNGLLKNVNTNRKDSFEVTYMNSFVQDTFKGDFVHAALTCPSQVPFLPLLAKLTATTQPSTSKNTITFPQRPFRLSAFIQAYSNPSLPVLGNEPLPPSAFTLHIEPPLAMSDVDYHHLLDYYKVAYCMPNLEGYQHPSSPFSFADNQIIKLKSINLLGQVYKGCKYASGRGSFVQSLFLGSQGNNRLAYTGQIQYLFLHSFTPPVDNTELQTRVVYQDKHVFAYVKWFQIEHDHSRELESVDICSADFIACDFKCILPVHRISSVVATCDYKTSTNNKKILVNALSHKQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L9R6</accession>
    <name>A0A167L9R6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_149097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287957.1">
        <property type="nucleotide sequence ID" value="XM_018432215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L9R6"/>
    <dbReference type="STRING" id="763407.A0A167L9R6"/>
    <dbReference type="GeneID" id="28993121"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149097"/>
    <dbReference type="InParanoid" id="A0A167L9R6"/>
    <dbReference type="OrthoDB" id="2262863at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF34">
        <property type="entry name" value="NOTOCHORD-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="509" mass="58279" checksum="ACA466270391E7D9" modified="2016-07-06" version="1">MSLLPAIIDDFKKLEKGVKMFSAEDNEYVLVVAPILWIEADTPCHSELCGLLGPATTFPCRRCYIELRRAKDFVKDLSYFCECHERRTREHYVLANSSPGRDTEIPNAPKIGMNTPANEISFRDRSTGCLLELQSFDPEKDTPVEILHTILLGVAKYMVIDLVKVVLKNDTATIARLSEFLTDYTRSTGLSRKFTRNLRHSSSFLSRDFKVLLQILPVILITEFSGNHELDLVIPCFVELGRLCSLVFVRQVTSDFDNYIIRVDNAVKRLIRALFDYNKGTKNELHKAYCTKPKVHYLTHLKEDIIRFGPALNYETEKGEQFNKHIREHLFHTNRQNTSRDVCLKFAKQVALQHVIDGGSWINSSGNQEKSGTGIERFIKDNNESLFYYTFFGGSRELKDNNNTGDIEDDAVQNNSFGAFVFKDDPISRPRIGLVSGSVVKFLSIVPRTDNDRNNNYAKAVMTGEHSDVANMNLVCKLDLHIFRNPFYIVNLSKFGSYWFIFNNILFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LU59</accession>
    <name>A0A167LU59_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHYBLDRAFT_155783</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289147.1">
        <property type="nucleotide sequence ID" value="XM_018433437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LU59"/>
    <dbReference type="FunCoup" id="A0A167LU59">
        <property type="interactions" value="535"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167LU59"/>
    <dbReference type="GeneID" id="28994343"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_155783"/>
    <dbReference type="InParanoid" id="A0A167LU59"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000092">
        <property type="entry name" value="Serine/threonine-protein kinase 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000499">
        <property type="entry name" value="Serine/threonine-protein kinase KIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="23"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAD71107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="306" mass="34400" checksum="33D0D9253F4EAADE" modified="2016-07-06" version="1">MLTNLGVSRQNSTRHSADPEEFYIKQERIGKGSFGEVFKGIEKKTNKPVAIKVIDLESAEDEIDDIQQEIAILSQLDSPFVTKYYGSYLKNTGLWIIMEYCSGGSCSDLMKAGVIREDHIMLIVRELLKGLDYLHTEGKLHRAANILLSASGEVKLADFGVSGQLTASLTKKNTFVGTPFWMAPEVIKQSGYNYKADIWSLGITAIELAKGEPPYADMHPMKVLFHIPKNQPPVLTGSYSKAFRDFIALCLQKDPNLRPTAKELLKHKFIKSHKKVSYLTELIELHERWLSHGHGRESDSSDDETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M0T3</accession>
    <name>A0A167M0T3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_170149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289517.1">
        <property type="nucleotide sequence ID" value="XM_018436263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M0T3"/>
    <dbReference type="GeneID" id="28997169"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170149"/>
    <dbReference type="InParanoid" id="A0A167M0T3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="170" mass="19313" checksum="75D77BC87FF0F3CF" modified="2016-07-06" version="1">MSYKKSVFQLNTASTLYQNTVHKYSRLILDALQPIFDTASVVSEEKGRKVTVLGLWSVCGVSMVMHRNMIRMEMNQVNTIKCSHVFYSNLYTADCIDDNAVELLLPNVLESSCLTRDLSEPIVAEWGADNILHTLNHSHTLSSPNVGGISYDNLCWIFQHNCFVVFFFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M1S8</accession>
    <name>A0A167M1S8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Senescence-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_156838</name>
        <name evidence="2" type="ORF">PHYBLDRAFT_75387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441036">
        <property type="protein sequence ID" value="OAD65072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283112.1">
        <property type="nucleotide sequence ID" value="XM_018433522.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289574.1">
        <property type="nucleotide sequence ID" value="XM_018443054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M1S8"/>
    <dbReference type="GeneID" id="28994428"/>
    <dbReference type="GeneID" id="29003960"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_156838"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_75387"/>
    <dbReference type="OrthoDB" id="2289888at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12217" checksum="94521B5716D7AC48" modified="2016-07-06" version="1">MIGRADIEESKSNVAMNAWLPQASYPCGSKGSIGHTFMVCIHTENQNQGDFYPFILREISVLAESPLGHLRYFLTDVPPQPNSPLDNVNNVGHAIKALKTRRWAVKPNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MER3</accession>
    <name>A0A167MER3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_145963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290686.1">
        <property type="nucleotide sequence ID" value="XM_018431566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MER3"/>
    <dbReference type="GeneID" id="28992472"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145963"/>
    <dbReference type="InParanoid" id="A0A167MER3"/>
    <dbReference type="OrthoDB" id="2506530at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33324">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33324:SF2">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="241" mass="27827" checksum="CF26E1FE8663C7F9" modified="2016-07-06" version="1">MSKHMASSTMTLIIVYPNSHQLAYQCWKDEDSSGKTKETLCSEINAIIVENDIIYQSNSDIRSKILYLHNKFKDATDFINGIGQGILNNVDKNGNSTAAAEKTLRDILINLIYISDMTISRPSTLAPFPMSNGDPTDVSNVFERARQYDKEATQFKTTFPVEYLSATSNYQRPSKQAQRTVDSNISNVVEESIKINREHFDLMQKKFKAKEEFYKRQLQHQKDICNDKMMFEKRRLEIEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MIB7</accession>
    <name>A0A167MIB7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_65153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290959.1">
        <property type="nucleotide sequence ID" value="XM_018441405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MIB7"/>
    <dbReference type="GeneID" id="29002311"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65153"/>
    <dbReference type="InParanoid" id="A0A167MIB7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="138" mass="15548" checksum="41B27208F5FA5EB4" modified="2016-07-06" version="1">MVKHIFSLSFLWIFIVFLLLLNIDPYNSVRNGPHIDQNIIIPKLLVKIVSDLNVTGNLTKNFAIMSQVQEKNGLYSTACIQPVTTPCLCWLKTYRNVLLVRDVGFPVSRYLDTIVGLLDNGEDSDICLNYPSKPHVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MJQ5</accession>
    <name>A0A167MJQ5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_146352</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD73039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291079.1">
        <property type="nucleotide sequence ID" value="XM_018431630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MJQ5"/>
    <dbReference type="FunCoup" id="A0A167MJQ5">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167MJQ5"/>
    <dbReference type="GeneID" id="28992536"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146352"/>
    <dbReference type="InParanoid" id="A0A167MJQ5"/>
    <dbReference type="OrthoDB" id="5835136at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03054">
        <property type="entry name" value="GST_N_Metaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01180">
        <property type="entry name" value="SUF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal" evidence="9">
        <location>
            <begin position="22"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="10">
        <location>
            <begin position="187"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD73039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="39123" checksum="F3677DF9F286F17F" modified="2016-07-06" version="1">MSSVQLYVWSPALDAPSIDPKCIVAEAYLRMLNKPYTVVHSNDPQTSPTGELPLLKDGAVWIAGLDRIIAHLTKKGINGNSNLNPEQKADSLAYNSLVQEKLYDIMLFTWYADMTNFVKSIRPIYGQILSFPSRYLVPIQLKKNAQARLAKYNIEIIGDDVELPQNEVEEMKELQRTGWHHMYQLARDTYGTLDKKLGDQKYMFGDEPSTLDCVVFGYLALHLYPNLAHRRLQHILKQEYPRLAQYCDRFKDTYFAEDQTLSSPAADIPSTWSTLLSNPRSFFSVVKDEFKPEDLSQNKEKKKSDEEIDFERKRVWSIAGGVTFLFAYVIFNGIVSVELED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MN49</accession>
    <name>A0A167MN49_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_187064</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291376.1">
        <property type="nucleotide sequence ID" value="XM_018439323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MN49"/>
    <dbReference type="STRING" id="763407.A0A167MN49"/>
    <dbReference type="GeneID" id="29000229"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_187064"/>
    <dbReference type="InParanoid" id="A0A167MN49"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000041">
        <property type="entry name" value="Chaperone protein DNAj, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="141"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="141"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="392"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD73336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="45800" checksum="A62AB4377A079C3E" modified="2016-07-06" version="1">MAVEAKYYEILEVEVDAEDHEIKKAYRKLAMKYHPDKNPEEGDRFKEISHAYEILSDPEKRAQYDRYGEDGPGGGAGGFGEGGLDDLFANLFGGGGGGGGAHFDFGGMGGMGGGYGMPPRSRKGESMKYPLQVTLEDLYNGKRTKLALEKNVICSNCSGKGGKTGAVKKCGGCQGRGFQVAMRQIGMGMIQQMQVPCGDCNATGEIAKDRCKKCKGKKVTVEKKYLEVFVEKGMSDGQKIVMKGEGDQEPGVEPGDVILVVNLKQHPIFERKSNDIICNLTITLTEALCGFEKVITHLDGRGIRVFHPAGSVIKPGMVKRIPHEGMPIYKRPDDRGDLYVKFDVEFPKDKFTTPENLKLLESILPARPAPAVSKHEIVDDCSLLMADIDSFGSTGNSKNAYEEDNDSDEEETTGTQCAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MRQ4</accession>
    <name>A0A167MRQ4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_124728</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291744.1">
        <property type="nucleotide sequence ID" value="XM_018429007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MRQ4"/>
    <dbReference type="STRING" id="763407.A0A167MRQ4"/>
    <dbReference type="GeneID" id="28989913"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_124728"/>
    <dbReference type="InParanoid" id="A0A167MRQ4"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD73704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="323" mass="36515" checksum="0ACDB7618360BC70" modified="2016-07-06" version="1">MASAEYVSLSRTGDKMPLVGFGCWKISPEDAENTIYDAIKTGYRLIDGAADYGNEVEVGRGINKAIKDGLVKREELFVVTKLWNTYHNKANVRPSFDRQLQDLGLEYIDLYLIHFPVPLKNVEKSAAYPPGWYAPNGATAIEFERSPMHECWRELEKIAESGLAKNIGISNFNVQLILDLLTYANIKPAVLQIELHPYLQQTRLVEWVQSQGINITAYSSFGPASFIQLTEDGKSAQPLLEHEVIKSIAKKHGKTAGQVLLRWSLDRNVAVIPKSMHVERMQSNRDITSWSLDSEDHKQIKTIDRGLRFNNMDSYGFNLPLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MSK2</accession>
    <name>A0A167MSK2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Endothelin-converting enzyme 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_112411</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291839.1">
        <property type="nucleotide sequence ID" value="XM_018428279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MSK2"/>
    <dbReference type="STRING" id="763407.A0A167MSK2"/>
    <dbReference type="GeneID" id="28989185"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_112411"/>
    <dbReference type="InParanoid" id="A0A167MSK2"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="9">
        <location>
            <begin position="24"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="8">
        <location>
            <begin position="510"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD73799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="719" mass="81390" checksum="2BFA3301572A9038" modified="2016-07-06" version="1" fragment="single">ICLEPHCILSAASILQDVNPDLDPCDDFYAYTCSNWIDNHVLPDAKSKVSVESLAKDRIKQRLNQILSHSNPLEKSLSSSSSLPRPDRIVDSQIFTKLTDFYGACMDEDTLDKRGIKPLYDQFRHIQGLLPASYLKQATLDPPFVQSLTEAMSHLGKQHIWALFEIRVVPDPHNPAKTALSLWQGEVGLPSRDYYDDPDVFSTYTKVVTELLELVFQKDTTGEFGWKSWSPVATARRILEFEKKLAQAKYHDDTIAVGTNRDGLNNGIIYERWSLEKLHATAPNVNWTLYVESMLPRGVPMPDDVLVPLPRFITSLSEDVLGSTNSRTLQTYLVWRTLWKYLDTLGEEFLAPRRKLEAKLNGVEARAKPERWETCLSHVDSSIGFLMGRYFVLSSLDSTSKTEAEGLASTIVTAFVDSLQGLSWVDDKTRKEMISKVQSMNYQLGYPSSFPDTQSAISLAEFYSSVNVKKDDFFGNVQSANEWAVKRQWAQLGKPVHNGVWDVNPQDVDATYSRKKNKAIVPAGMLQPPFYDSQGPDYLNYGSLGWVIGQTMLHGFDLTGRQYNKEGALGQWWSNHSMSEFNNRTRCFVQQYSNFTLKGPQEDIHQVDGERTLDSNLADNGGLAEAYSAWNTRFSQGRNNAHLPGLVNWSVEQLFFINFSRMKCSKSTPESDVRELRTSESAPDRWRVNGPLINSREFSKAFQCAVGTPMNPHAKCDMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N8D6</accession>
    <name>A0A167N8D6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHYBLDRAFT_64244</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293359.1">
        <property type="nucleotide sequence ID" value="XM_018441260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N8D6"/>
    <dbReference type="STRING" id="763407.A0A167N8D6"/>
    <dbReference type="GeneID" id="29002166"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64244"/>
    <dbReference type="InParanoid" id="A0A167N8D6"/>
    <dbReference type="OrthoDB" id="415460at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000097">
        <property type="entry name" value="Potassium voltage-gated channel subfamily G member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF254">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="116"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAD75319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="510" mass="58114" checksum="F0E3442ADF02EF63" modified="2016-07-06" version="1">MMNLFGKYRYAKQSTDETSEHEDQEPKYNKNEETIELIERPTATSTTITQTSPTIVSHDQQWVTLSALVDDEDHSANQTYHQYGDGTDAVAESMTHHVKQQLYLLLEAPSSSRAAFWINVVVSMLIVLSAVMTTMETIPAFRSEDSNRLWQVSIYYFILEGMQNKRNSEIKLLDLFQLEVAMVSLFTLEYLLRVFAHSDSLGMIKHFFLSPLSIIDFISIVPFYIELLAKRDTTYEFRFTILRLFRLLRLFKTYQYSNTIAMTIEVLVLAMRRSSDALSALFFFLVTSVVLFSTLLYFAERGVWDSTVETFVNPGGNPSSFDSIPAAFWFVLVTITTTGYGDMVPATFIGKLVTFPAMMFGVLLIALPSIIVGRNFTTVWEIMRRHEQPNHSEPDRGPYWPHNRDALANARQEAVDALPGRTSFEETKEALAQLERLTGIARQHQEALHHIMALIQTQDTTQPLNRDKAGSIYSTISIFDPVGRKKEKAKYTSTQVHKLCAMIKVQGPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N8U5</accession>
    <name>A0A167N8U5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_123858</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293394.1">
        <property type="nucleotide sequence ID" value="XM_018428957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N8U5"/>
    <dbReference type="STRING" id="763407.A0A167N8U5"/>
    <dbReference type="GeneID" id="28989863"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_123858"/>
    <dbReference type="InParanoid" id="A0A167N8U5"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050129">
        <property type="entry name" value="Zn_alcohol_dh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401:SF2">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="7"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD75354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="335" mass="35578" checksum="375067BE218FE6E8" modified="2016-07-06" version="1">MSVASWQKLGSIDIIQKKVPAIKAGEVLVKVAASGICGTDLHICRGETPHASQKVVIGHEFSGNIVAVHEQSKTSLSVGDLVSIDPNVPCNACSFCRNKKYHLCNDLFCIGVTVDGGMSEYVAVPITAVYSVPSHVTPEVACLAEPLSCVVHAVDMGEIKSGDRVLIIGAGPIGMMALALCSTGGAHVTIIEPNEMRRKMATSIFKANVAVAPGALVPGDGAKGEGYDVVFECVGRPETMSQAVQFAKAGGTVVWVGVAKTDARVSVSPFDVYRKELTIRSTYTNPFGMDRAVKILADEKVDWSSLVTHSFPLRDFDEAWKVFLTGTGLKVCIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NAM2</accession>
    <name>A0A167NAM2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_64425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293549.1">
        <property type="nucleotide sequence ID" value="XM_018441291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NAM2"/>
    <dbReference type="GeneID" id="29002197"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64425"/>
    <dbReference type="InParanoid" id="A0A167NAM2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="228" mass="26350" checksum="1045DD8A69F857F5" modified="2016-07-06" version="1">MDNQSSLSVHPLSIPPLSYVMASTYTSEVAKQYLIAQDALYPRNHIIFTCSGGSSMDYIFEKDRDYSYRCSEVNSMEATCCKRERKSERLDSFFAQRHLSYDIFMQGIYYWLNQIPRMTIGVMLGVSPETIRHLIASIHQLIQMDLTNNDMRIDKFIREVLMPMINPLLLKLMKANLERGNITEDIESVEWNKNEPQGQIVNKTNGAMNVDGIHMEKKNMRTDCGKEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NQ09</accession>
    <name>A0A167NQ09_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_110058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294469.1">
        <property type="nucleotide sequence ID" value="XM_018428149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NQ09"/>
    <dbReference type="STRING" id="763407.A0A167NQ09"/>
    <dbReference type="GeneID" id="28989055"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_110058"/>
    <dbReference type="InParanoid" id="A0A167NQ09"/>
    <dbReference type="OrthoDB" id="10257948at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02989">
        <property type="entry name" value="Phd_like_TxnDC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21148">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="26"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="132" mass="15414" checksum="293D011173A5E461" modified="2016-07-06" version="1">MHNCTRLERRQAMSENKHGLYTEIDNEKEFMNITTSEKYVVGHFFHKDFRRCKIMDTHLEKLAAKHYGTRFIRIDVQNAPFLVEKLQVQTLPCVMAWVNGYCQIKLIGFDELGNSDGFQTSLLELKLNNSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NSA1</accession>
    <name>A0A167NSA1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_165096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294608.1">
        <property type="nucleotide sequence ID" value="XM_018435162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NSA1"/>
    <dbReference type="GeneID" id="28996068"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165096"/>
    <dbReference type="InParanoid" id="A0A167NSA1"/>
    <dbReference type="OrthoDB" id="10376047at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="236" mass="27027" checksum="2B0D15007852E0E3" modified="2016-07-06" version="1">MTTCSSRNLCITSPLFWFPPASSYPKLCSPPTKKPPNKVDWGHPVERDRDTWLIHLLCPKECYTHTRHLTSPVEPCICRGYCTIFSELDKNEPSWPCVMSCSLEYRGGQNHRPRLTLPLSPPSTQLVEHEDHKGPSVDCPSSKDTFVDYEKRDLLQAWLDSIPEYYPLLDDQKYLDMPIWQETNSNPSPNRICPPPLTTTTRPKVALPKSAKRETFFGVVSQWVVRIKKGLSIELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NTK3</accession>
    <name>A0A167NTK3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_180138</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294618.1">
        <property type="nucleotide sequence ID" value="XM_018438269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NTK3"/>
    <dbReference type="STRING" id="763407.A0A167NTK3"/>
    <dbReference type="GeneID" id="28999175"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_180138"/>
    <dbReference type="InParanoid" id="A0A167NTK3"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF107">
        <property type="entry name" value="CHOLINE_CARNITINE ACYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="6">
        <location>
            <begin position="46"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD76578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="630" mass="69716" checksum="63CF9D18EB464831" modified="2016-07-06" version="1">MVGAPLLSVSRRAFNSSGRLNVKNSLSSNYSTATKTFGNQSILPRLPIPELDATAARYKRSLLPLLSAAEHAQVSQKIDRFVKKDGLGQTLQARMHALDEQEAKLGLSWLDRLWLNRGYLEYRIPTVLNVNWWSQFRDHPDGLISQVPEGTITDFQISRSAGLVSGLLDYSNKINDEAIPPEASRSGPFCMHQIRHMFGTSRIAANPRDTIVTSCPATAKHITVIYKDQIFAVPVLGPNGETVPLKTLENQLRQVVSRVDQLPKEQLQPPVGLMTSEHRDTWGEVRKELETIPTNASTFSAIDSSLFTLCLDNYSSPDDKDLSHRNLAHGKGAHNRWFDKALQIIVESNGRAGINGEHSPCDAVVPQRTVESVLMQEPIVDNLATSNISQLPAPTHLQWSISSKTDQQLKAAQENVDKLIADYDSVLLHYDAYGSDFMKKAKVSPDGWLQMAYQLAYYRQYGKPCPTYESASTRKFLTGRTETVRSCSVESMKDKLALFGNAIASQSEYMKASSNGHGVDRHLLGLRCQMTPEEAASEEAAIFQDPSYWGSQYWLLSTSNTSPGDLSWGGFGAVVPEGYGANYAIAKQGVKMSISAWNSCADTDATSFRKTVRGVLDEFGQVAEDYLVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NUJ8</accession>
    <name>A0A167NUJ8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_157968</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL53 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294679.1">
        <property type="nucleotide sequence ID" value="XM_018433708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NUJ8"/>
    <dbReference type="FunCoup" id="A0A167NUJ8">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167NUJ8"/>
    <dbReference type="GeneID" id="28994614"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157968"/>
    <dbReference type="InParanoid" id="A0A167NUJ8"/>
    <dbReference type="OrthoDB" id="4136894at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019716">
        <property type="entry name" value="Ribosomal_mL53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042776">
        <property type="entry name" value="Ribosomal_mL53_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28236">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L44, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28236:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10780">
        <property type="entry name" value="MRP_L53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD76639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="100" mass="11347" checksum="B5F62B7904354037" modified="2016-07-06" version="1">MWVKQINEVRIALSPFNTASKSSRLFINRISTNESRKLNPTIKIVTDVLADPKAESVINVLYRDGKTLKVESDKLKIDNLVQVVSKHAKKLEEAEQAKAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P4Y9</accession>
    <name>A0A167P4Y9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="17">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PHYBLDRAFT_185425</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </cofactor>
        <text evidence="17">A monovalent cation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 17">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="17"/>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295296.1">
        <property type="nucleotide sequence ID" value="XM_018439075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P4Y9"/>
    <dbReference type="FunCoup" id="A0A167P4Y9">
        <property type="interactions" value="510"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167P4Y9"/>
    <dbReference type="GeneID" id="28999981"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_185425"/>
    <dbReference type="InParanoid" id="A0A167P4Y9"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023600">
        <property type="entry name" value="Folylpolyglutamate_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038895">
        <property type="entry name" value="FPGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OAD77256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="512" mass="57184" checksum="09531B06365E9673" modified="2016-07-06" version="1">MTDFKIAIERINSLQTNASLLEKLRKAGPRANELSLPEMRDYFKRIGYEVKTFDKLNVIHVTGTKGKGSTSAITQSILRNCSDEKPIRTGLFTSPHLISVRERIRINGEPVSEELFAKYSNEVWDRLESTKEEALIKAGLSEKDLKASLRDQRQHPDKPIYFRYLTLVAFHTFIQEKVDVAILEVGVGGEYDSTNVVERPVVCGITALGLDHVGVLGHTIDKIAWHKAGIIKNHVPAIAFEQLPEAMQVIEERAKEKEAPLQVLHARDIDALKDVEIGLAGVHQKYNALTAIALCKIWLKHCRQIELTETVPAGFRKGLANVKWPGRGQQLCATETKYASQIPNPRDVTWYLDGAHTLESLQVCVDWFRQVAKDKKDIKDVSRILVFNTSNGRDGPNLLQVISKIQSFVGFDHVIFTTNMTYREGDSADNTNYTVSMADVLSMQALLAESWVKQVPSFNAENVHVVGSLEEATEWIVDYAKSAPETKKVQILATGSLIMVGNTLTVLGITPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P7G9</accession>
    <name>A0A167P7G9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_141291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295444.1">
        <property type="nucleotide sequence ID" value="XM_018430558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P7G9"/>
    <dbReference type="GeneID" id="28991464"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141291"/>
    <dbReference type="InParanoid" id="A0A167P7G9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="121" mass="14050" checksum="7FDC3685D1D73D59" modified="2016-07-06" version="1">MERENGVRQLELHELVHSNAVEYTIIDLMHNLFFGTPKLIMKKWISTGLISNAHLIAMQDDADKLHKSWYLVYSPAVLSGSLPQKHFDNWMCFFNACWYLAMPSLTYKNLAEAHFCLELFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P9N2</accession>
    <name>A0A167P9N2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_60664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295574.1">
        <property type="nucleotide sequence ID" value="XM_018440678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P9N2"/>
    <dbReference type="STRING" id="763407.A0A167P9N2"/>
    <dbReference type="GeneID" id="29001584"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_60664"/>
    <dbReference type="InParanoid" id="A0A167P9N2"/>
    <dbReference type="OrthoDB" id="2281765at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD77534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="344" mass="37948" checksum="5960201B5E79E639" modified="2016-07-06" version="1">MSPKGSTNTNVFKKVPPRQSRLAKSSADQTFCSPENAQLKAILDEALARAAIHEEHHKALLSKIDVIVEHSIALQEQNSTLTEELRIANEHVEFLHNQLQLQVQVPGASTFTTTTLPPTEIAPVENFSAEASAHGPVTISTPSPTTFLAAAKKAMGKRPNQPKLTTAQATRALQPESGPSAYAFVYLPCRHHLKYSQVRKLLKTFKIQQSRVLDIAFPERGTLSLLVHNDFKDKITQLFADIGVSVKTDFDPLDHRIIADPAHAHKPVQDRQQLAYKLHHQRLLALCLRLPAPLGKSVMRHFCTVESSSLRLPPVCLEQYLEDRNLPSGPQASAIDTATAMVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PJU5</accession>
    <name>A0A167PJU5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_141962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD78096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296136.1">
        <property type="nucleotide sequence ID" value="XM_018430709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PJU5"/>
    <dbReference type="STRING" id="763407.A0A167PJU5"/>
    <dbReference type="GeneID" id="28991615"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141962"/>
    <dbReference type="InParanoid" id="A0A167PJU5"/>
    <dbReference type="OrthoDB" id="2506088at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="657" mass="74846" checksum="06E7E88805ADE7C7" modified="2016-07-06" version="1">MIEEEQEEAMEENISSLKERIFNMASLTINSNVESDFSILAFEDCQSLLDFSAASAFVDWDNSMISVSMLTKIMYTINLLFELKKRADEDKVEFKLPKVGTLLNYQHNKFNKIPLFPTTAIIAPLAIFSDDTSGNLPKTYIMYNTVSQQAGFKSTQLMSILAVDLKSLENSIEMYLSTYNETVTVCALLLFITADNAHHAKLVGLKHATSNFPYRRCYHRSLTRFSFDDFDSDHLVRHFQRRTKEHCRIAATDPTCKEKAIPSVLLNIDNIYMRMEKPIDKMSILTDLGYSHTGAKGLLCLQSFDPALDTPEVLKGNTALQVKLSNLLEQEKGSRDFTRTFRKKLRHSGSYLDKELIILVQVLPAILNAEFANDTEVSMIAKPFTELGILLSLLFVQEVNSDFDQYLSNVNNTARLLVKSLWKYDVYSNTKFSLTLKTHLLLHLKEDIKRFGCALYFETEKGEQFNKFIQTHLVYSNYRADNRDLAFKFEKQDMLRHIASGSSWINRTTGTQVKSGSSISAFLQDQGIKYSDNYFGKYQEFVDSNHVKTKVVTGVSVAFFYKDNICRLFVGRIMESNSILCIQYYQLFSPNLNLATVGCQPSEHYCNLEEIKIECMLHLTSGVHLSSFGLLSISIGCFSKKQNFSDLQTLQALQALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q087</accession>
    <name>A0A167Q087_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_163950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296896.1">
        <property type="nucleotide sequence ID" value="XM_018434909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q087"/>
    <dbReference type="GeneID" id="28995815"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_163950"/>
    <dbReference type="InParanoid" id="A0A167Q087"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="268" mass="31028" checksum="B0641DF09526431E" modified="2016-07-06" version="1">MSRNLNNNSVNNAFGEKPSVGSPPRNTNDIRTIMLQHSQGTVSNQRPLAPKKARLNLESDLSGRTRNIHDVYEKLDTMNSVLNTVLKNTSSEKAEATASNTVEQDMLPGHQPTLDQLLRNYLSEKKFEGNRLVLKSVTDYLRHQEEGKKSCERRQSVLKANRAHFVNSFGENVDSIFHADYMSDLESDDERDEEEQDSFSEKHFFWRFHPSWRSKEGDRFVDELDVDYEAAHDKKNNTRLFEHKFKGIRDKQLSKTKANKLPSWSKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q504</accession>
    <name>A0A167Q504_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_164157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD79076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297116.1">
        <property type="nucleotide sequence ID" value="XM_018434957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q504"/>
    <dbReference type="GeneID" id="28995863"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164157"/>
    <dbReference type="InParanoid" id="A0A167Q504"/>
    <dbReference type="OrthoDB" id="2263388at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD79076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="322" mass="36437" checksum="46E8EC8E0B2A70D3" modified="2016-07-06" version="1">MSSSNASQQRDRISTQQYQCDQCVLFFDNYQKLQNHKRIHRGDSATMTEIDQSILNDVDMYHDKNDTSNEDESVSNSEYTMESMKLDNTISYKCTCNFEDSEGEAHIYDSSRISTNTFTKAELISIHLSQLMLRYRIARAAYRDIVQFINIVIRDHDDIMMEPGAKISHGKTVDALLKSKSSVKGHEYDVCSSGCQLYGINDNQKSCVDCGKPQYKTDPNQSQTPATSMKIMSVGDMLSQMLADPATRELLCYRANQESVAGQLTDIFDGDNYKQLVQQGLFSNSDDIAIGLYTNGFVNQKKGKNSYTIIHCIIFNLDPSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q6B4</accession>
    <name>A0A167Q6B4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_184665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297188.1">
        <property type="nucleotide sequence ID" value="XM_018438970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q6B4"/>
    <dbReference type="STRING" id="763407.A0A167Q6B4"/>
    <dbReference type="GeneID" id="28999876"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_184665"/>
    <dbReference type="InParanoid" id="A0A167Q6B4"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD79148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="572" mass="64139" checksum="7A3602D2E51C7126" modified="2016-07-06" version="1">MSPTEKSTIEVAQPTSKDIVETLDIEPTLSAKEEAPKWPSVPTLSVDEVVSQAVKESNSAVKEPFQFKKPIRRAAVIGTGPAGVPTIKALHAQGIEVRAFDRNPKAGGIWAYSDAPSAKPKMPSTELAPKSKNVAPVVGIHEETVELTNEVEKSLLEQYPASACYKDLYTNTPIKITEYIDFPGDHSKTYMWHQEFQDYLSRYLTHFGLDSLIEYNTNVEHVYKAKDEEGSECWHLTLCKSERVEGNKIHVKRWTETFDAVAIATGIHQNPKIPAFEFLEEFDARWPEKCSHSKQYRIPEPFRDLNVLVVGGHTSAVDITRHLEGISKNVYLSYRGPREIESNILGLIRTGVPESTIIMPALTSLSNADGLVDGTVKFIDGQTLENIDRIVFCTGFTSDYSFLDDLIIEDHDEYVKLGHESVSVPATDGQTVFNSYRHLFFIPDPTLTFIGAPPNLTTVPFFDYQARAVARVWAGKALLPTQKNMFSYTKEYKPVCYPLSFGAEPELLRCEDLVVWLNSHAEALGHTDLPPVLNHNKWMDTVWAHAVPNFRNDSDAKLAEVKERVKLRMASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QMV0</accession>
    <name>A0A167QMV0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_75733</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297987.1">
        <property type="nucleotide sequence ID" value="XM_018443092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QMV0"/>
    <dbReference type="STRING" id="763407.A0A167QMV0"/>
    <dbReference type="GeneID" id="29003998"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_75733"/>
    <dbReference type="InParanoid" id="A0A167QMV0"/>
    <dbReference type="OrthoDB" id="5564519at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007891586" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="24"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="119"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD79947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="227" mass="23102" checksum="DC185C58BE4D29C7" modified="2016-07-06" version="1">MKFSIFASVSILAAVAHAKVRIISPDADTVWKAGESATIKWKSDGKDSSLTCDIQLLNGDPKDADIIGTLTKDGAPKCSENSFTVDSLDDYPSGTVFMRIGQNSKHKWSYSEDFKFKGDGSASSGSASSSSGSGSGSGSDSKPSGPSSSAPSKATPTDATSTQAPANNGGSGEATPTDSWLNTSPAATPTTPPQTESNTAESDEAASVLSRFSSISSSVAAARATNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R0X1</accession>
    <name>A0A167R0X1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_138144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298629.1">
        <property type="nucleotide sequence ID" value="XM_018429944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R0X1"/>
    <dbReference type="STRING" id="763407.A0A167R0X1"/>
    <dbReference type="GeneID" id="28990850"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138144"/>
    <dbReference type="InParanoid" id="A0A167R0X1"/>
    <dbReference type="OrthoDB" id="2263825at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007891775" evidence="1">
        <location>
            <begin position="17"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="297" mass="33231" checksum="60190A858B1650C7" modified="2016-07-06" version="1">MKLSLVFVALFAVGHGLPISLDDSILESSTVENIEPANEPFVVQIDQFTQLVSTHLHFDHLEPIISTTYREISGQLQHHIEITVHDTSLDTQPYDNIRQHSFQQSQSLEGMDIEILQAQISGAIQAHTEGNLPLAWDKVADKLSRPALEAYLAQLISTRCGINAGFPVQADQADSGCLMEKAVSLSSSIDDYIANNLSETFLTLDQTVLPDLLEHTARDLKQVLDYFNAVFLRHDERQLSLRVIPWNEHTNHANIADTANIDIQTFSSKLLQLASRSLSSDDHPIEFFFNYANLARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R180</accession>
    <name>A0A167R180_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="8">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_129275</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eIF-5A family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298654.1">
        <property type="nucleotide sequence ID" value="XM_018429276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R180"/>
    <dbReference type="FunCoup" id="A0A167R180">
        <property type="interactions" value="499"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167R180"/>
    <dbReference type="GeneID" id="28990182"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_129275"/>
    <dbReference type="InParanoid" id="A0A167R180"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006452">
        <property type="term" value="P:translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0385">Hypusine</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="9">
        <location>
            <begin position="85"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD80614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="158" mass="17271" checksum="4714ED5BBEFAD1AD" modified="2016-07-06" version="1">MSDDHDHTFESADAGSSLTYPMQCSALRKGGHVVIKGRPCKIVEMSTSKTGKHGHAKVHLVAIDIFTQKKLEDLSPSTHNMDVPNVVRMEYALLNIDDGFLSLMLPDGSTKDDVKLPENEVGTQMEEEFEDGKELLVSVVSAMGEEHALSYKEAPKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R3M5</accession>
    <name>A0A167R3M5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial presequence protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_29346</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298808.1">
        <property type="nucleotide sequence ID" value="XM_018439945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R3M5"/>
    <dbReference type="FunCoup" id="A0A167R3M5">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167R3M5"/>
    <dbReference type="GeneID" id="29000851"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_29346"/>
    <dbReference type="InParanoid" id="A0A167R3M5"/>
    <dbReference type="OrthoDB" id="4953at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000015">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000031">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF16">
        <property type="entry name" value="METALLOPROTEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="2">
        <location>
            <begin position="53"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="3">
        <location>
            <begin position="194"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD80768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1002" mass="112130" checksum="A7B30C09DEE853E2" modified="2016-07-06" version="1">MGNFELICEVPTDFGATYTKYKSTKSGLTVVLSDIEAPLVNGYFVLATESFDDFGCPHTLEHLVFLGSEQFPYKGVLDSLANRAIAQGTNAWTDVDHTCYTITTAGSQGFLKLLPIYVDHVLYPTLTESGYYTEVHHINGEGEDAGKFVVYSEMQGCQNSSSDRLHLRMKRILYPETCGYRSETGGLMERLRELSVEKIRDYHKAYYRPDNLCLIITGKVDPADLMKALEPVEENILSKGPLPPMQRPWVSTGDFPNLTKNIEETVLFADEDESMGTVLIAWNGPKCHEYFTMKALEVLNLYLTDSPVSVLQKEFVEIEDPLCTGISFDSTDHLKTTLMLTASNVPIEEIDEFPAQLFETLQRLVEANDIDMERMKMVIEKEILKVCRTVPSNSGICIDFLYGSEDGEDLKKAVKDKEYLAQLIDLTVSDWINLLKTWYLDQFHVVLLGKPSAEFAEQMTEEENQRIEKQREDLGEKKLEELHDALEKAMAANDVPVPNEILDNFVIPSVSTIKFIDVQSAQNNSKSIKNAVQEHINRDNSADIPFFIQFDHIKSAFIKLTAHISASSIPSHLLPYTRIFLKSIFSLPVERDGMTLTYEEVVKGLSEDTLEYDSGLGTSSGFRELAVFSIKVEASKYKKAIKWLQDILWHTQFTAERLKIVANQILNDIPQSKRDGHSMTIACMRIIQYDATKSVSASRNVLFQTAFLTNLLQTLENDPNSVVKELNIYRDALCNPANIRLHVAGDILKLEEPRTSFKDFSNNGPLAPITLAQDVLSAAGISPGETGVIINLPSIENSFSMHSTKGPSKFDDPDIAPLLIMIELLDTMEGIFWKLIRGQGLAYSCFLDSDVEAGEISFSIYKSPDASKAFEQAKFVIDQLTTKKMEIELSAVDGAKSAVIYSMVSRENTMDRAALQSFANQVLKHMPASYNRSLLTAIQATKVEDLYRVLDKYFVSLFDPKTSNHVVVSTSAKVPEIQKSFSSLGFNLKSTTLNDIAGDASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R411</accession>
    <name>A0A167R411_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_161441</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298838.1">
        <property type="nucleotide sequence ID" value="XM_018434403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R411"/>
    <dbReference type="STRING" id="763407.A0A167R411"/>
    <dbReference type="GeneID" id="28995309"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161441"/>
    <dbReference type="InParanoid" id="A0A167R411"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="32"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD80798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="349" mass="40963" checksum="33C3295F182123CA" modified="2016-07-06" version="1">MSQDTWTFSNTDSLLGYAFAFYFLEKRNNGTSKHNIRLLCRNKDGLEELERLGGEVIEVDYRNECDIQTAIAGTRFLMFNPEFSGKRIWEAKTLLNASKCEGVEYVTITSFIGVDRVLREMHNNKHDFSNMVEYYHLEEQVRHLFGDDNHCVVRLPFFSQSLYYFSPMIEKESMIGMPVDTKARWPILSLLDVVQGMYHLWTENQIKRLNHIESNKALFQFTSAYNQDGKGLSIIFSEVLGRTTQYTQISASNMRAYLQDIRENENFQERPFSQESKDPERPERDVPFTFPIARYLNDNYIDTLLELWLMFDCGFSDILTDDLSNALGYMPQELSSFVQNNRDQFRRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N235</accession>
    <name>A0A162N235_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_73927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285758.1">
        <property type="nucleotide sequence ID" value="XM_018442947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N235"/>
    <dbReference type="STRING" id="763407.A0A162N235"/>
    <dbReference type="GeneID" id="29003853"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73927"/>
    <dbReference type="InParanoid" id="A0A162N235"/>
    <dbReference type="OrthoDB" id="77564at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="264" mass="30757" checksum="F206F56E6F9B6F4C" modified="2016-07-06" version="1" fragment="single">RAQFNARIVNNYLSGNIVPKPSVEELIETARLPTRPDSPEISHISPVYFKIFWIRGRTLRINTKNRAKSNLERSIDDLKEAIVLFTNHIYLCPNDFYGWYDLALCFSQLAEEILVYSTARLPSYKNEIAQYQKKAFLAFVRAWYLANEYNLKFSDSTLFELYAHFGELVFSMTGSPMNMEAFKTTSVSRFTLADGKVRIVADPEMGKKLAYKLVIKLFSKALKYDSPDDSHWKFSMHDSDYISYDDITIIWDTSVDYYKHNYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NJ68</accession>
    <name>A0A162NJ68_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit 6A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_74407</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288204.1">
        <property type="nucleotide sequence ID" value="XM_018443018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NJ68"/>
    <dbReference type="FunCoup" id="A0A162NJ68">
        <property type="interactions" value="442"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NJ68"/>
    <dbReference type="GeneID" id="29003924"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_74407"/>
    <dbReference type="InParanoid" id="A0A162NJ68"/>
    <dbReference type="OrthoDB" id="9443236at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000009">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000076">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="209"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD70164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="429" mass="48190" checksum="F3B349A975C9575D" modified="2016-07-06" version="1">MANLEDASLWKEQEGEDAVDQEILRLAPEEVNNRTRLLENDIKVMRSEITRISHEQANMKERIKDNAEKIKMNKQLPYLVGNVVELLDVDPDEEEEEGANVDLDSTRKGKCAVIKTSTRQTIFLPLIGLVDPETLKPGDIIGVNKDSYLILDTLPAEYDSRVKAMEVDEKPTEDYNDIGGLDKQIEELVEAVVLPMTHADRFKNIGIRPPKGVLMYGPPGTGKTLLARACAAQTNSTYLKLAGPQLVQMFIGDGAKLVRDAFELAKEKAPTIIFIDELDAIGTKRFDSEKSGDREVQRTMLELLNQLDGFSSDERIKVIAATNRIDILDPALLRSGRLDRKIEFPLPNEEGRARIIQIHSRKMNVSKDVNFQELSRCCDEFNGAQCKAVCVESGMLALRRGAVEITHEDFMDAIQEVQAKKKMTLQYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NJV2</accession>
    <name>A0A162NJV2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chromatin associated protein KTI12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_115766</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Interacts with the elongator complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KTI12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288384.1">
        <property type="nucleotide sequence ID" value="XM_018428479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NJV2"/>
    <dbReference type="FunCoup" id="A0A162NJV2">
        <property type="interactions" value="334"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NJV2"/>
    <dbReference type="GeneID" id="28989385"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_115766"/>
    <dbReference type="InParanoid" id="A0A162NJV2"/>
    <dbReference type="OrthoDB" id="9972657at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000827">
        <property type="entry name" value="KTI12 chromatin-associated homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12435">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00063730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD70344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="31811" checksum="63659C48DE33AAD0" modified="2016-07-06" version="1">MPLIILTGYPSSGKTQRAAEINKYLLDRLEAENKSLKIHWINDESLNVHRDAYKDAREEKKARGAMMSAVERLLSKDAIVIADGLNYIKGFRYQLYCVARAISTPHCVVHTGAPVQLAREWNATRTDGYEPIVFDELVTRYEEPEARNRWDSPLFTVIYDDKEIPGDKIWDAVILRKPPPPNLSTVTKPVSDTNYVYELDKATLEIINAVIEGQKEFGPGGMPMTVPRSSEKVVNPSRTVTLSELRRLRKQFVSLNRVRTSLDVNRIGDMFADYLNTNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NL65</accession>
    <name>A0A162NL65_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartyl aminopeptidase</fullName>
            <ecNumber evidence="4">3.4.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_123781</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.</text>
            <dbReference type="EC" id="3.4.11.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.21" evidence="4"/>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293278.1">
        <property type="nucleotide sequence ID" value="XM_018428951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NL65"/>
    <dbReference type="FunCoup" id="A0A162NL65">
        <property type="interactions" value="383"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NL65"/>
    <dbReference type="GeneID" id="28989857"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_123781"/>
    <dbReference type="InParanoid" id="A0A162NL65"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002759">
        <property type="entry name" value="PRK02813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF3">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD75238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="469" mass="51619" checksum="D593F315F38013D6" modified="2016-07-06" version="1">MLLKSDIPQDALDFIEFVNKSPSPFHATHEASVLLKAAGFKEIKERDSWNNGVLEQNGKYYFTRNGSSIVAFIVGGKYQPGNGFSMVGAHTDSPCLKIKPVSKKEKSGYLEVGVQLYGGGIWHTWFDRDLSIAGRVLVSHEDGTFKHTLVKIDRPLLRIPTLAIHLDRSTNDGFQFNKETQLAPVLATATKAALSGSDATDGVEADATHHPLLIRILAEEMNVGPDQIRDFELALYDTQASTIGGACNEFIFSPRLDNLEMSFCSIQALIRSKDVENDTNIRLVALFDNEEIGSQTAHGADSNLLPVTLQRLANTQLMNVSASSTAFEEAMHKSLLISADMAHAVHPNYSDKHEENHRPQMHKGTVIKVNANQRYATTAMTSLVLKELAKKHSIPIQEFVVRNDSSCGSTIGPMLSAKLGLRTVDIGNPQLSMHSIREVGGTDDVKHGINLLQVFFEEFAELEARIQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PSW9</accession>
    <name>A0A162PSW9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PPPDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_13629</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291626.1">
        <property type="nucleotide sequence ID" value="XM_018429775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PSW9"/>
    <dbReference type="FunCoup" id="A0A162PSW9">
        <property type="interactions" value="106"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162PSW9"/>
    <dbReference type="GeneID" id="28990681"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_13629"/>
    <dbReference type="InParanoid" id="A0A162PSW9"/>
    <dbReference type="OrthoDB" id="412286at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101005">
        <property type="term" value="F:deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF80">
        <property type="entry name" value="IP06716P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="5">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="126"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD73586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="175" mass="19992" checksum="301A9FBC4198EDF8" modified="2016-07-06" version="1" fragment="single">IVFTLGIYHSGLELDDREYCFGGHERIDETGVFVMEPRVGPPNVLYKRSIDMGCTAYTEEEIQDILITLSKDFVGPSYSLLKRNCNHFSSKLCLLLTGRPAPSWINRAAHLGTFFPCIITDDLVQPPDFDDSSEEENDVHHDHSNVRNNQDHYADDYSYDNDDNDNDTNNNKNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PV27</accession>
    <name>A0A162PV27_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_111901</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RICTOR family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292336.1">
        <property type="nucleotide sequence ID" value="XM_018428247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PV27"/>
    <dbReference type="FunCoup" id="A0A162PV27">
        <property type="interactions" value="293"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162PV27"/>
    <dbReference type="GeneID" id="28989153"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_111901"/>
    <dbReference type="InParanoid" id="A0A162PV27"/>
    <dbReference type="OrthoDB" id="271111at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028268">
        <property type="entry name" value="Pianissimo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028267">
        <property type="entry name" value="Pianissimo_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029453">
        <property type="entry name" value="Rictor_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029451">
        <property type="entry name" value="RICTOR_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029452">
        <property type="entry name" value="RICTOR_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298">
        <property type="entry name" value="CYTOSOLIC REGULATOR PIANISSIMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298:SF11">
        <property type="entry name" value="RAPAMYCIN-INSENSITIVE COMPANION OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14663">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14666">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14664">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14668">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01303">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01307">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01308">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01310">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR middle" evidence="2">
        <location>
            <begin position="362"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR" evidence="4">
        <location>
            <begin position="762"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD74296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1009" mass="114833" checksum="72B63523036D2C92" modified="2016-07-06" version="1" fragment="single">RALARDPEQHEPEREQTVKLVRSFIEYGGVKYISQNVVRAVVAIAEQPDCRLRNISLETLAELSILDIGLTVRSGGLRVVMQALLDGQLNMAEVLMPAIMYVLDTPDKRCFLRPGVELELLISPFTESNKGVNCEERLKNSARVVSLMLKNWAGIFYMCANNMRAARSVVLALKMPVPETQKMVLDMFFDIFRVKLPKDYNNFLSGRQHTVHIDPSAAEPINPTPRRERLKLLDHHLSIILIIFIESDILMALIDMVKSDDVYISRKATLLIGEILQLSTRLLPISMGIQVQSLPKLFALASNFDDEQVRHNATAALAHIDKLTRARARYVTPLPTKGERLATSTRTQEKVHEVKLKIGYAIDDTHFRQLLMDSQVLNTKDYTKWCWDSIIELLQGPLLNPRRLDEAMRGKKFIKRLLAFYRPFKHQFSDIKANKPSITRYVKYGCTLLSTLLGHQDGVRYLGENKLFSEIGEALSELGPLNNNSENEPIFSKERMENTLTAGYFTLLGTLSKHKEGVRMLEKFKLFSLFYQLSELKNRDDIKVAMITNLDYTLDGHPRVLLSKIMTSGYNPIRLFATQYLGVIMRQSESEYNDWIIRLLVTQLYDTHLDVCQEAVNLLDEACERPANLELLVKFRPSLGHLGEIGNPLLLRFLSTSTGFRYLNALGYVHKEMDEWFEHRNKHYVAQLELSLARALINTPDKKSLNPFEERVDRDGLTPPHFYGELTKTEEGCNLLKDRGHFQLFVKDIRNYSVENHDVEELRKLKAVLWAVGNIGATRNGLPFLEEEDVVKDIVAMADSSEVLSLKGTCYYVLGLISKTKQGMELLSELGWEGVLGPHGGAEGLCVPLNLRVFLTIRNWKYSAGLPQPPRLPLSATRDPIASDILKNIGDMSNHIMANEASKNLAKLRQRYPESFQRVDLYYAVCQLLGSYHFRSPVRKYVLEIFDMRFTPELLQGLDDVAARLIPDEGWSNQDSQPRLGSGHIHTETVVQQEKLVPKTIKIGFNIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PY38</accession>
    <name>A0A162PY38_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_142579</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295107.1">
        <property type="nucleotide sequence ID" value="XM_018430840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PY38"/>
    <dbReference type="FunCoup" id="A0A162PY38">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162PY38"/>
    <dbReference type="GeneID" id="28991746"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_142579"/>
    <dbReference type="InParanoid" id="A0A162PY38"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="155"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD77067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="496" mass="57208" checksum="362882A79C7CAB6D" modified="2016-07-06" version="1">MLFSIPILDRLTFRDYQGLILTVFFFGFENVIRVIVTFLPKFVINLIDAFIDSTFPWLSKLDSDPHVSPLEKAESFEKMMLIWKNYMCEQHLVRTQDDYLLCVHRIPAVVQSADKFKDKDVFRSFCDENSKGIEIIDHINEFKQQKTNSNFSGKPVVLLYHGFLMSSEVWVCNVDEYRNLPLLLAQQGYDVWLGNARGNKYSQNHLKLNPRHQQFWEFSINEFAMIDLPDVVDYILKITGAPNLTYIGFSQGTAQAFAGLSVNPKLNQKINLFIALAPATAPKGLRHPLIDTFVKATPSVIYLLFGRKTPLKLALFWQRIISPPMFVKLIDGSVGFLFGWTGKNMTADQKLVSYQHLYSLTSVKSLVHWFQIIRVGRFQMYDEMPSRLPYHTVNAVMDHVPPKFPTNQITTPIAIFYGRSDSLVDFNVLAADLPSPLVYVKSIKSWEHLDFLWAEDIETIVYPDILRLIDYFNPFPQNTERKKLDTVVPLPIKAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PZ03</accession>
    <name>A0A162PZ03_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_60426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295337.1">
        <property type="nucleotide sequence ID" value="XM_018440640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PZ03"/>
    <dbReference type="GeneID" id="29001546"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_60426"/>
    <dbReference type="InParanoid" id="A0A162PZ03"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="189" mass="21162" checksum="FE25DF80B5A1C3D2" modified="2016-07-06" version="1">MTGGIYMAHNQLCDYTTVSKKIIAKESGLVRRYNGSSASGHAGVKKTSTPRMLSTEDMTSSEERLVFERQISWGVYGASHNAVAAPVIPSESVYKWFVDLSSNVASIWIPHLVKDMVKVVSLWLGLSHQSCWVHVWRGKKDNCINVILEFITEYWISGKLRVGAPQPQPLSCFVVGHELKSIHYQAIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q0A5</accession>
    <name>A0A162Q0A5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_102049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294036.1">
        <property type="nucleotide sequence ID" value="XM_018427659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q0A5"/>
    <dbReference type="STRING" id="763407.A0A162Q0A5"/>
    <dbReference type="GeneID" id="28988565"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_102049"/>
    <dbReference type="InParanoid" id="A0A162Q0A5"/>
    <dbReference type="OrthoDB" id="2439011at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="177" mass="20210" checksum="D693EDB2148B2172" modified="2016-07-06" version="1" fragment="single">NLPRSERFKAENTILVGLMPGPKEPKSEEINHYLKPLVNEMIQLYLGIQIPTYQQTDGATVRAALLMVACDISAARKTSGFTAHNSTCTCYKCDNQFSHLPGTSSVDFRGFDCDQWRHRSDRANRVHAEEWNSASTPSERQQLEVEYGVRWLQLYRLGYFDLVRGTIIDPMHNLFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q4I2</accession>
    <name>A0A162Q4I2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CYP5208 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_139998</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298026.1">
        <property type="nucleotide sequence ID" value="XM_018430315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q4I2"/>
    <dbReference type="STRING" id="763407.A0A162Q4I2"/>
    <dbReference type="GeneID" id="28991221"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139998"/>
    <dbReference type="InParanoid" id="A0A162Q4I2"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF5">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="1 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD79986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="531" mass="60137" checksum="AFB052C3607162CD" modified="2016-07-06" version="1">MESLYLHSSFPWATTKLSLFGTIVSAVALGTILYLVNPGKPRDTATQNLPPSAPNRLPILGHLLFFVKPDYLPELFRQWSFIVGPVYTVYLGRKRWVILNSAAAVKDLIVDRGSIYSSRDLPDIMVNTLMNGVDKGGGFAFFPYGKQWRNLRRIAHSGLILKKIDLYQPILNDRRKVLLGNISRAIDDTKAISLTKYIEHFAMTNILTIAFADLCSFEPGDPKLHEVFSITERSATLLGPSEQLVEFFPILKYILPNHIKKFQDLRQEILDFYGDLLREFKARLKKDPSKVKDCFMKEILAMDVLTDIQCMYFIALFVGAGSETITSTLEWMLVLLANNPEFQDRAFAEIEQNVGLDRLPTAEDEHKLPFIQCIIHETLRIRSPAPISVPHSTSKDDVYNGSFIPEGTTVVINVHAIHLEESKYPDAKKFLPDRHMDYVLDNEKKLFSSQSVEGRPHIGFSAGRRACVGIHLAERTLFTVAAGILACFRIERETDELLNDYTPKDNRAATFAPTPYKVRLVHRHKGVSNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q4U6</accession>
    <name>A0A162Q4U6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_163126</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298116.1">
        <property type="nucleotide sequence ID" value="XM_018434732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q4U6"/>
    <dbReference type="FunCoup" id="A0A162Q4U6">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162Q4U6"/>
    <dbReference type="GeneID" id="28995638"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_163126"/>
    <dbReference type="InParanoid" id="A0A162Q4U6"/>
    <dbReference type="OrthoDB" id="10266426at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015215">
        <property type="term" value="F:nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000075">
        <property type="entry name" value="Nicotinamide adenine dinucleotide transporter 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="7"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="107"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="203"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD80076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="32915" checksum="6341B872992948CC" modified="2016-07-06" version="1">MSVSQTHENSKHAVAGALAGLASAFITCPLDVVKTRLQNQGKAQPGQVVYRGTLGTLSKMWKDEGIRGLYRGLGPTIFGYLPTWAIYFTVYDYCKNSWASGNGQHDKDWVVHITSAMTAGAASTTLTNPLWVIKTRFMTQNSLTDYRYKNTLDAFVTIARQEGIRGFYKGLGPSLLGVSHVALQFPMYEKLKYLLQTDADVPSGSVAILMASSISKMAASMATYPHEVIRTRLQNQARKPFKYHGILHAIKVISLEEGFRGFYKGMPTNLLRTVPSSAITILTYEVIVQKIDEFKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162SZY9</accession>
    <name>A0A162SZY9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_176408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441015">
        <property type="protein sequence ID" value="OAD65132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283172.1">
        <property type="nucleotide sequence ID" value="XM_018437759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162SZY9"/>
    <dbReference type="STRING" id="763407.A0A162SZY9"/>
    <dbReference type="GeneID" id="28998665"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176408"/>
    <dbReference type="InParanoid" id="A0A162SZY9"/>
    <dbReference type="OrthoDB" id="2283382at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD65132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="157" mass="17847" checksum="0E3D5EA3DD69578D" modified="2016-07-06" version="1">MLDSYTAMEMVEKLSDTVFTCRSFTVDLVIYNIELQNGFLQNCTCPDTSKLCKHIFLINRMLDIPYSLCQSLSSSSSAVHVSNTDTKAVVDTSLLSDEIEADIINYYQLYSVELDSKIAAYMEISEDVSKFLNTLKFAYNKLTKYGFPSQSRPPQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T5F3</accession>
    <name>A0A162T5F3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_175213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441003">
        <property type="protein sequence ID" value="OAD66402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284442.1">
        <property type="nucleotide sequence ID" value="XM_018437448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T5F3"/>
    <dbReference type="STRING" id="763407.A0A162T5F3"/>
    <dbReference type="GeneID" id="28998354"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175213"/>
    <dbReference type="InParanoid" id="A0A162T5F3"/>
    <dbReference type="OrthoDB" id="2237019at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="228" mass="26284" checksum="3DF5FEBF7E097277" modified="2016-07-06" version="1">MYRPSFLDPGRKTVFTAAVGLDPNEHQLRHCTTKEYYHLTGSTLYARKLQQEKDTAGITAIESATPSAKTGRNIQFLRYADYMLPNMDTLFTFCDYNTAKYRFNLYQGKQRAPDMMVNILLSGSARYNRRRHFRKKNRKQERQNKKDKSKVPFVVFGNGMFGKDRVKLKGLRCSVAGDLLVLPIDEHPASKICKICKSRTLIDHPNVKGKFIVQKFILIRPEKETGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T5H2</accession>
    <name>A0A162T5H2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_175222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441003">
        <property type="protein sequence ID" value="OAD66412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284452.1">
        <property type="nucleotide sequence ID" value="XM_018437450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T5H2"/>
    <dbReference type="GeneID" id="28998356"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175222"/>
    <dbReference type="InParanoid" id="A0A162T5H2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="396" mass="45470" checksum="9738475437EEB788" modified="2016-07-06" version="1">MSFDSFQIIFVDPSKPGQPRQPFRSAVIAAEIVDTNDVTASDYKVTDIREVGEKENEDANDSDSDEDQEENGEGESSSKIVKSRIWCRDSTRLLLKVILDTDTDGKIRAAKRNKQRIGRIWIDLFEAFKNEPGFDNLPQKFKSSVNIFKCNNKFKLLKKSFEQSLDRDSTQAGGDVGHSRGTWFDELRKITLNDPSFNAPALDSSELDSVKPTITRKPPTQKITKEHIDSSHPLEIIYERFVPVEEPETICPSTANRPIFPHRVQPQYNDDMNSALELMATSHTSISEDMRLSALSLMDSFVGTSEEKAQKKRRVDKVIEIWERHTATYEKDVKTRARKESRKEREAEAKNVDRERRARRDEELLLKQRRMNDMLARIIQRNDKGSNSQNTDNGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TFD4</accession>
    <name>A0A162TFD4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_117787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286192.1">
        <property type="nucleotide sequence ID" value="XM_018428594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TFD4"/>
    <dbReference type="FunCoup" id="A0A162TFD4">
        <property type="interactions" value="288"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TFD4"/>
    <dbReference type="GeneID" id="28989500"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_117787"/>
    <dbReference type="InParanoid" id="A0A162TFD4"/>
    <dbReference type="OrthoDB" id="62at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="128" mass="15430" checksum="A6E853A9D467DF6D" modified="2016-07-06" version="1" fragment="single">SLLCGYLYIKGLTSELSELTTYFEGEIIGPKYSFLTRKWHAVQDIDRQHWELFEPFKPLIDCFNKEDFVYDPIDNDMVYMRWKERFLVPNHHINNIDGASFAGFYYIAYQRSTDKITGFYFYHLNIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TMP5</accession>
    <name>A0A162TMP5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_68946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286433.1">
        <property type="nucleotide sequence ID" value="XM_018442031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TMP5"/>
    <dbReference type="GeneID" id="29002937"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_68946"/>
    <dbReference type="InParanoid" id="A0A162TMP5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="112" mass="12939" checksum="15424243CEE149F8" modified="2016-07-06" version="1">MLKFECGETSSILNKDLVMKWPPSVKFYIFSLEFRSPRKAKEMSFRLPNWQRSSISCSPSNINQSCPSHYLSTVIYYESSDLRKEILVVLETKKSFQGMTVIMACKKTNVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TV67</accession>
    <name>A0A162TV67_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_71522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288123.1">
        <property type="nucleotide sequence ID" value="XM_018442491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TV67"/>
    <dbReference type="GeneID" id="29003397"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71522"/>
    <dbReference type="InParanoid" id="A0A162TV67"/>
    <dbReference type="OrthoDB" id="3247418at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="322" mass="37042" checksum="75C5256A6F66A152" modified="2016-07-06" version="1">MHLHLHFKETVLNFGPVYGYRLFSFERYNGVLKNYTTNNKDGFEGTFMRRYLEDTRKIDLFHTTMQSLQTPSQVSLIYDLVDSFLTLVTVTAATTTTIVPTALYLSTTSSGFNLKIFLASAEVNINNVKGNKPLRSSVFPLSLDEVFSMKEDEYVLLLELYCMAYSNTSLRGYQDVIFGQLFMNNMIQKMQPINLLGQVYKGSNGIVRHGSIIQAMFHENNNHEMSAFTGQIQYLFVSNIINPVTYQVDRHIFAYFMWYRTSSQDTRSEQFVEMSEFLFTRSNFQNILSAYRILMPAAIGVHTTATGNTHMLIAPLYRKIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TVY7</accession>
    <name>A0A162TVY7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_159630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288293.1">
        <property type="nucleotide sequence ID" value="XM_018434025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TVY7"/>
    <dbReference type="STRING" id="763407.A0A162TVY7"/>
    <dbReference type="GeneID" id="28994931"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159630"/>
    <dbReference type="InParanoid" id="A0A162TVY7"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD70253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="228" mass="26049" checksum="90E4B78E3663A9F3" modified="2016-07-06" version="1">MESDPFIEITMQLANVALNTHAMDTMDLPVIARLLGNSRDHDCLESLVHLRIHLTQKINDSSHAMEIVIAWGLLERLRCLLQINEPDIQFECAWIITNLAAGEPKYQKHIIDAGFFLPLLYCLSYAGHSRARIQASWALSNLTAESVILREQWMYHGAHTMINQLKLLCAEDIVHDLSIVEDKRVLGWSLSNMCRGGFNSTNYQEMASNMNVLNNTILIWCYHDCFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TW04</accession>
    <name>A0A162TW04_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_170787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289462.1">
        <property type="nucleotide sequence ID" value="XM_018436429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TW04"/>
    <dbReference type="GeneID" id="28997335"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170787"/>
    <dbReference type="InParanoid" id="A0A162TW04"/>
    <dbReference type="OrthoDB" id="2444110at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007839965" description="F-box domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="648" mass="74969" checksum="706B85B9E66E7AE3" modified="2016-07-06" version="1">MSSVRNLKTTFAFFLFSLIIMQASQLPFEIIACIARFLTVKQKLSCITVCQAWRTPFEESLWDTIVVGSRARLESICDLTDIQHNVYRKNGHLVRVLKLMILLRDDQLRIVQECFCSLKQLNTIGRSLTKSSLEAEVDWSYWSSLTCLIIQIDDLKIQIPVEKLLEILSFLPCLKHLDYFKPIWSPNPIYTLQDFEALHNYLPQLKRLSVSANFAEFTPNDITYITQNTFHVKHLAELFIDSCQVDLRWLYYFARKYPNLNTIKWRNSDWKVPTTIFKEEAAVMISRLPCMFPHIKTVLNMNALPKEWVKTVFWDPLSRSGALLNYMRHGLYREHNTTDKAQLCSSESMRSCLKSIESLYVEAESFFSDPCSIPMAFDFCRSLVNLDIDIHGSPIAIDLLLDRCDSLKKLKLIVSSVTTASDIHSHPNIHGLQSIEFEKATISAIVLHYISFRCIYLKCMRMNTIKVFGKFSHDTKSLLIDMSYTRFNLLQLNNVMFYASSSGICDSGNAINILQLVRPNLALQPIKTHDLSMILPRGGLLTMLLELRWFHIYKICKFYYNMVKLRIFGTEESQDSKTSFESYHHVNKLRVGHREVTSYACNQDYSNGSVKDINRGYASLRCGYVKKYDMGNLDNCEKLTLENSCKTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TXU6</accession>
    <name>A0A162TXU6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heat shock factor-type transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_103994</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288733.1">
        <property type="nucleotide sequence ID" value="XM_018427805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TXU6"/>
    <dbReference type="STRING" id="763407.A0A162TXU6"/>
    <dbReference type="GeneID" id="28988711"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_103994"/>
    <dbReference type="InParanoid" id="A0A162TXU6"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="8">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD70693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="94" mass="11318" checksum="7B49AE755C604CC1" modified="2016-07-06" version="1" fragment="single">RMLEDPEIQELISWSRSGDLFSVANPTVFSKIVLPQYFKHNNWQSFVRQLNMYGFHKVNDMIHSNLTNETQTWEFRHPHFRRGAVDDLQNIKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TY36</accession>
    <name>A0A162TY36_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_169845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD71932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289972.1">
        <property type="nucleotide sequence ID" value="XM_018436174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TY36"/>
    <dbReference type="GeneID" id="28997080"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169845"/>
    <dbReference type="InParanoid" id="A0A162TY36"/>
    <dbReference type="OrthoDB" id="2263388at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD71932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="322" mass="36539" checksum="1DD321F66069F009" modified="2016-07-06" version="1">MSSSNASQQRDRISTQQYQCDQCVLFFDNYQKLQNHKRIHRGDSATMTEIDQSILDDVDMYHDENDTSNEDESVSNSEYTMESMELDNTISYKCACNFEDSEGEAHIYNSSQISTNTFTKAELMSIHLSQLMLQHRIARAAYRDIVQFINTVIRDHDDIMMEPGAKISHGETVDALLKSKSSVKGHEYDVCSSGCQLYGINDDQESCVDCGKPRYKTDPNQSQTPATSMKLMSVGDMLSQMLADPATRELLCYRANRESVAGQLTDIFYSDNYKQLVQQSLFSNLNDIAIGLYTNGFLNQKKGKNSYTIIHCIIFNLDPSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U1F6</accession>
    <name>A0A162U1F6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DBF4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_70112</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289593.1">
        <property type="nucleotide sequence ID" value="XM_018442216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U1F6"/>
    <dbReference type="FunCoup" id="A0A162U1F6">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162U1F6"/>
    <dbReference type="GeneID" id="29003122"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70112"/>
    <dbReference type="InParanoid" id="A0A162U1F6"/>
    <dbReference type="OrthoDB" id="21380at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010571">
        <property type="term" value="P:positive regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901987">
        <property type="term" value="P:regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3410:FF:000001">
        <property type="entry name" value="Protein DBF4 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="entry name" value="DBF zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013939">
        <property type="entry name" value="Regulatory_Dfp1/Him1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051590">
        <property type="entry name" value="Replication_Regulatory_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375">
        <property type="entry name" value="ACTIVATOR OF S-PHASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375:SF26">
        <property type="entry name" value="PROTEIN CHIFFON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08630">
        <property type="entry name" value="Dfp1_Him1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00586">
        <property type="entry name" value="ZnF_DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DBF4-type" evidence="6">
        <location>
            <begin position="462"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="371"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD71553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="631" mass="71199" checksum="CADAE178D9B2FCA2" modified="2016-07-06" version="1">MEQTKRPSETPMKRHLTRPTENTKSIPRGRSSKPVVQQTVNPNPTKLADPPARTGQLVEETSRITRKDFCKFKIFLDSVDDATRKNVERKLKLLGVTLEPFFSKNCTHFITTKPFTPPKQTKQINAEISTKSAPLTEISNRENNSDFKIIMNRKQLNPFGTGIPTRIPAPAAPPQEELVDKAFRLNLQVWGLHDMLRCIQTILDGSNRSQRKEDVAPRGLANVLKEEKTHGVRTGIAGDANSSRPHFVPFKGYYALVEDVTGVCRPTVIKEYTKSLSQSAVERRPWPFLKDTPYGKSPFAQAIIPDDSQLKTGASGSQEQQFGRPTQTANRLPLGTHGIVPLQPKRQTTRQIPSDSLFRVSGFHPSVVQSTTSRTALASGSTMVPAEGRHLAPGDNVGRLTRRTVEVKNTREPKNEAIANVVNSAVLNFQQMQLNNNNTQDNQVKPAAEKTNGQTDRRGGNAVEEVWYCENCNRKFSSYEKHIKEDAHQAFIRDSNNFSVLDDLLSKTRRSYKEPLPLHMKPKVDPNIDGKNVRFQHSNKRSYALAVATNDDDQYPNKFQRHKIEDNEDTSEMTSTIVDDSWEKYYSVFFIWLINIGGDAKFYRIKKIQGCDIKTPSVFGLFIGTAFIPFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U1V0</accession>
    <name>A0A162U1V0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_65277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290842.1">
        <property type="nucleotide sequence ID" value="XM_018441428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U1V0"/>
    <dbReference type="STRING" id="763407.A0A162U1V0"/>
    <dbReference type="GeneID" id="29002334"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65277"/>
    <dbReference type="InParanoid" id="A0A162U1V0"/>
    <dbReference type="OrthoDB" id="2137681at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="732" mass="84065" checksum="5D33193D3FAF81A0" modified="2016-07-06" version="1">MGSTDAHMQPHTSPNVPQVLVKPDLSTDNKSNPSKAHKNVPEADAVEPSSRLGAFFDSWPTLSRVISQSNPHSHSPTPSPPPSPIRTPVNEEYRNLESDPISLSGKQLDSNGNKLNSIGVGRKVNNLLEHDDVKEAVATLNNAVAYMSMSDTVSNENPEQVAKIYSEMLHTLCEPKILNIVNEISGVDLKKFPQDITRCIMWRLFIKVVQAGYTLEKASYLEVIYQIMHYGLYKLAIKALYSMPRRLWDTDTYKLAITLHLMQTPRQIEQAEWLLTDYGKAYLDLADPKSPASDSPLIRIDTPLMKKVTDQDKFNMWIFYQARLGESDWIKERSVWQSSRENMVPRPKSLAEWVTKRLESDTSKRTKEECENIDENNTAIFVSMGNQQYEYGWQIYQSMGELLNKFTPRVIMHLCWRAHKDTPLSKKARRSAWETRAWELYSRFMCSVYLTAHQPEMPGFLGDLLSISATSPEREEDSRFAKTMQVYYLLEHNNLKHLLCNEQVLTPILCTILHECHGPPSTIMKMCRKAFNIWYTKQKLDTQNHIEVPESFSIDWALLVLCLKSGDIHDFLDVLEHICRVHRTLPSSLLAPIQRFHDMYLNCDAQPGEQPIICCYFDHYLFRKIQYTDDPTQTISMDELGFIEENDSGDNSRDTDTSEGTEPMAYLYHALHRRTNIKDFQAASLAMAVSMGIAQDEILTKKKMYCSAKKVYALIQHCLKVSRARLRNKTEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U4S3</accession>
    <name>A0A162U4S3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_146523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290363.1">
        <property type="nucleotide sequence ID" value="XM_018431667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U4S3"/>
    <dbReference type="GeneID" id="28992573"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146523"/>
    <dbReference type="InParanoid" id="A0A162U4S3"/>
    <dbReference type="OrthoDB" id="2404656at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="154" mass="17649" checksum="AD2A74C29DBB6EA2" modified="2016-07-06" version="1">MPTSKNREESFILYLPTLSTTALQQPCNASSATMTHFEGNYERAWWVDIDPKLWEKGKPWFADGLGYDWTGGKRLVMEGSSGQHEEKIPKTVDNSVKQVHSMIEMLKCIANTHTNSSFSTFLLTKVFDVQTMKTTIILSELQTDYEGKFIQRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UJ30</accession>
    <name>A0A162UJ30_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_177040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294612.1">
        <property type="nucleotide sequence ID" value="XM_018437849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UJ30"/>
    <dbReference type="FunCoup" id="A0A162UJ30">
        <property type="interactions" value="909"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UJ30"/>
    <dbReference type="GeneID" id="28998755"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_177040"/>
    <dbReference type="InParanoid" id="A0A162UJ30"/>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="10">
        <location>
            <begin position="255"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="9">
        <location>
            <begin position="319"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD76572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="524" mass="59621" checksum="E03A7600B58E5CD3" modified="2016-07-06" version="1">MSSTCLLFVTRQKQLSTKDQAIFCPGCGTPTPPNASNMCVNCIRNEVDITEGIPKQATIHFCKGCERYLQPPGIWVTAQLESRELLTLCLKKLKGLTKVRLIDAGFIWTEPHSRRIKVKLTIQKEVFANTILQQIFEVEYIVSTQQCDECTRLAAQNTWKAAVQVRQKVEHKRTFLYLEQLILKHNVHKDTTNIKEAKDGIDFFYGQRGHAIKMVEFLSSVTPTRYKTSEQLISTDIHTSTSNYKFTYSVEIAPVCKDDIVCIPKKLAKLMGNIPQLLLVTRISNSIHLMDINTLNQVDVLCVTYWRHQFTALASVKNMVEFYVLDVEPLGPVKGKHVLADVHVARMADFGRNDDVYICRSHLGAILSPGDTVLGYDLSRSNFNNEDFDKLDRSALPDVFLVRKTFPARRKKNKQRNWKIQQLGKEVDEMLPRKQDQARIDNDMEAFLRDIEEDPEFRSTINIFKNAAANAAATGGAVDSDMVDEDEDDEEEEFPEISLAEMLDEITINDDGPDEPEAAYMDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UT27</accession>
    <name>A0A162UT27_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_164635</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the anamorsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295783.1">
        <property type="nucleotide sequence ID" value="XM_018435051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UT27"/>
    <dbReference type="STRING" id="763407.A0A162UT27"/>
    <dbReference type="GeneID" id="28995957"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164635"/>
    <dbReference type="InParanoid" id="A0A162UT27"/>
    <dbReference type="OrthoDB" id="311633at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03115">
        <property type="entry name" value="Anamorsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049011">
        <property type="entry name" value="Anamorsin_N_metazoan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20922">
        <property type="entry name" value="Anamorsin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anamorsin N-terminal" evidence="13">
        <location>
            <begin position="10"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Anamorsin C-terminal" evidence="12">
        <location>
            <begin position="238"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="189"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site B" evidence="10">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 1" evidence="10">
        <location>
            <begin position="293"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 2" evidence="10">
        <location>
            <begin position="304"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD77743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="332" mass="35891" checksum="A8D024633804A822" modified="2016-07-06" version="1">MSSSIEIQPGQAILFVGSSTVEQDQWIKMRSSALAQAGPQANIAFEIMERVADASLPKSSFDGIYSNIFSPSVSVHTPAILSRYLSTLKAGGRLVVEEPIVLVSLSNTVCPVTRQQDELVSMLKLAGFVDVEASVQPVSDQQLAQFFQIWGATRVEQGVSRLTGKFGWAHVTAKKPAYEVGQKMTLRFGKKKESPTPTPTAAAKKSVWTLETDDTMEDDDALLDDDDLVKPSKESLSRPDDCELTDGKRKACKNCTCGRAEEEEAQVVSLELEDDMEDEIVEVDPTAKKVGGCGSCALGDAFRCSTCPYLGMPSFTPGQTVTLGGQFGMDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UXJ6</accession>
    <name>A0A162UXJ6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_179618</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296663.1">
        <property type="nucleotide sequence ID" value="XM_018438177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UXJ6"/>
    <dbReference type="STRING" id="763407.A0A162UXJ6"/>
    <dbReference type="GeneID" id="28999083"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179618"/>
    <dbReference type="InParanoid" id="A0A162UXJ6"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16563">
        <property type="entry name" value="RING-HC_RNF220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052443">
        <property type="entry name" value="E3_ubiq-ligase_RNF220-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031824">
        <property type="entry name" value="RNF220_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040178">
        <property type="entry name" value="RNF220_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13459">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF220 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13459:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF220 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15926">
        <property type="entry name" value="RNF220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="403"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD78623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="455" mass="50880" checksum="6F0BE31FAB4D4361" modified="2016-07-06" version="1">MSSSSTNPDPAIPPQTLSNAQKSRSTTKRRSKGLHRELQFLVDDNGKRAKRDQPKCPICEHRIDPAHWEIHFNYELERLGQLESDIYNNPLNKNRGKRGAAVVARQQLEKTNHKKRAPSAYESTLEKIQKNRAHRKEVLQKLDSPRQLEDSAAAYDETLALTRALYEEEQGSRQDSNSNSSAQVCFICNQALHGDSDAVNLHIDHCLANLNSSVEPEDTEDEPMIDNTENESRENSGAGTSPLSARWEEYEWAGQTRVRATSMMEGGYRGAGFATTSKEEDVDEDLDVEDDDAAQFGESQYTERDIVVNSDDDNENASALREMVSGGMTRGSTATASVQDGDEGEVDSPRSGFEETVSDAGWERHLTHSNQMNSNSGQSRLVVDSLKARIQQLEAASRSVPRCLICLEGYKTPLASIVCWHVHCEQCWLQTLGSKKLCPQCQKITTPSDLRRIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V4M7</accession>
    <name>A0A162V4M7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carbohydrate esterase family 2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_184973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297952.1">
        <property type="nucleotide sequence ID" value="XM_018439011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V4M7"/>
    <dbReference type="GeneID" id="28999917"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_184973"/>
    <dbReference type="InParanoid" id="A0A162V4M7"/>
    <dbReference type="OrthoDB" id="426133at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052762">
        <property type="entry name" value="PCW_deacetylase/CE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37834:SF2">
        <property type="entry name" value="ESTERASE, SGNH HYDROLASE-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37834">
        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G00620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD79912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="575" mass="62807" checksum="276CE3A593EE2A52" modified="2016-07-06" version="1">MIVLLSRISVSVVFKSTNKYSLKPDSTAIVDDRAVSGGVYATEEQNDILIPFNDPNIMYFGRWRTSTNSIQSGWPGAYFKTTIYGPRIRLILKGPTHVYVQIDTEKPKDYRTQSENGEAIELDITPQIDLGQGPHQLTVAACTNASIELESLLLSDERGTGPVDVLSSTVEFVGHDLTLGKYTSQTILTSYAWAVSEILGTEHAQIALPGARLMDGKDGRGMESQYFEWSPSHTKEARAKWDFSSYKPAAIVILLGRNDYGTEAYEQSLERFLLQVRTHTGPASILVLSEPLGEMVRSSQLAVSRRNDLGDENVHFVDTTNWVRYGPSAFVDPGHLNDVGHQTVARKLAPLLQAKLARPRQPFPGPLPNPTLPNGWQTMDVGHELSIGLPGSVSFDSGNTFTLWGSGADISGTRDAFRFVYQALSGDGTLEATVESHSTFASCAKAGIIIREHLSLGSPHVMLGISPADGLFLQTRSQNMNDTRLLKKSRASPPYRLRLIRKDNVFVAQMMRTSVAPPIWDTLGNVSTTFLARDVYAGLAVTSCDTAVVSVAKFVDVSLQGGVGSGSGLRFIDQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162W9P5</accession>
    <name>A0A162W9P5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glucuronate decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHYBLDRAFT_89642</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>UDP-alpha-D-glucuronate + H(+) = UDP-alpha-D-xylose + CO2</text>
            <dbReference type="Rhea" id="RHEA:23916"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="EC" id="4.1.1.35"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="6"/>
    <dbReference type="EMBL" id="KV441008">
        <property type="protein sequence ID" value="OAD65685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283725.1">
        <property type="nucleotide sequence ID" value="XM_018443728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162W9P5"/>
    <dbReference type="STRING" id="763407.A0A162W9P5"/>
    <dbReference type="GeneID" id="29004633"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_89642"/>
    <dbReference type="InParanoid" id="A0A162W9P5"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="UniPathway" id="UPA00796">
        <property type="reaction ID" value="UER00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033320">
        <property type="term" value="P:UDP-D-xylose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05230">
        <property type="entry name" value="UGD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000150">
        <property type="entry name" value="UDP-glucuronic acid decarboxylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078:SF6">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="17">
        <location>
            <begin position="30"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAD65685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="344" mass="39325" checksum="61BC7874C11B553B" modified="2016-07-06" version="1" fragment="single">DKVNDTVVYKSIKSFPSVRRLQPSERKRILVTGGAGFVGSHLVDRLMIMGHEVIVLDNFFTGTKRNVQHWIGHPHFELVRHDVVDPFMIEVSQIYHLACPASPPHYQYNPTKTVKTSVMGTINMLGLAKRTKARFLLTSTSEVYGDPEEHPQKETYWGHVNPIGPRACYDEGKRIAETLTYSYMRQNDVDVRVARIFNTYGPRMSPVDGRVVSNFIMQALRGESLTIYGDGGQTRSFQYVHDLVDGLILLMNKNYYEPVNIGNPDEYTIRDFADIIREKVLLSPISPDDVPIKTLPCPTDDPKKRKPDITRAKTYLGWKPNFDVHQGLQETVDWFRLQMTEGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WC75</accession>
    <name>A0A162WC75_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_152776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441005">
        <property type="protein sequence ID" value="OAD66205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284245.1">
        <property type="nucleotide sequence ID" value="XM_018432991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WC75"/>
    <dbReference type="GeneID" id="28993897"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152776"/>
    <dbReference type="InParanoid" id="A0A162WC75"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="299" mass="33708" checksum="1B2C2E85007A994C" modified="2016-07-06" version="1">MAPRTNINQNARTNGSTSRPLINAVNTGLSEFNDVVSLLATLNDKMTAVSSDVSELKVQCQVGAQSTGMQAVLDSDMDPQNIISSSRHPKISSIIWGRLRDINLKTDDLELIKENDDKPTWDVNVGLSDKFNKNLASDLMLYICCQPVAAMVSPKELCGIIVNSYYNRLTASKLTEEDRQTNTTSNRRGNRKTALNKRRKRMYTKHKDAITEKFNWDYNGVFYRDAMSGDETETDTSVVASRPGWRSDELNTVFDFLDELARDDLGKRATQLKSRSHVLVHETIPRGLVTKMPTWSKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WGK9</accession>
    <name>A0A162WGK9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_151934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD66995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285035.1">
        <property type="nucleotide sequence ID" value="XM_018432792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WGK9"/>
    <dbReference type="GeneID" id="28993698"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151934"/>
    <dbReference type="InParanoid" id="A0A162WGK9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="295" mass="33820" checksum="A819387027A950DA" modified="2016-07-06" version="1">MYLHPSPCSNLYTISSRFSLHSSMFSHISPRCFLFDLRSPFPLVEPKSLQISSISLRRHAHGPLLLCSNRRSPTLLSTNLPTNKNRTIRKFKPLDCDPLLPWILPNSRPRTHSTLGSPLHFVLKAVDHLPHKFDDVLTNLSTCLLLPLSSMVNTPAPSHPLCRPSWQDLKVNNLYQIDHNLNVPIPIVPVRPLPRSITLPRILQRLLEKLFLAHPIVFRACIPTFILESRHLNMPPRDVSPIDFTRFLSALVFGKAWARLSTRSYRMTCSHQHVHAQSFNPYLILEKVSTFTYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WHU7</accession>
    <name>A0A162WHU7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_151823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441025">
        <property type="protein sequence ID" value="OAD67215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285255.1">
        <property type="nucleotide sequence ID" value="XM_018432755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WHU7"/>
    <dbReference type="GeneID" id="28993661"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151823"/>
    <dbReference type="InParanoid" id="A0A162WHU7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="123" mass="13993" checksum="661DD05995EFD1F4" modified="2016-07-06" version="1">MSKEYQAQAFRTLIKRLESRRAQRQSYLNLLEGSSAPMNNQLVLPEDQKKRIFAIIDGTNFMILDVAVNHVPRRFHGNHFPAENGTESSLRFPGPTLCSCSSRQLCAPRPKFVHSTYKTALQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WI30</accession>
    <name>A0A162WI30_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_174313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285315.1">
        <property type="nucleotide sequence ID" value="XM_018437226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WI30"/>
    <dbReference type="GeneID" id="28998132"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174313"/>
    <dbReference type="InParanoid" id="A0A162WI30"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="132" mass="15264" checksum="314BF5EBCBA02103" modified="2016-07-06" version="1">MLIYPIPMIVALFGEPEDISQSSSSSIASWLTKKKHLRRKLGIMSRDKQVAESKDVYITTKARKTCKIQTEKSKRPFSNLLRNDGFMADAVLFNKVNRSAEDYKFCCEQEVDIEHVVQTVVNRDPARFFLWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WIY5</accession>
    <name>A0A162WIY5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_57737</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285485.1">
        <property type="nucleotide sequence ID" value="XM_018440247.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A162WIY5">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162WIY5"/>
    <dbReference type="GeneID" id="29001153"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_57737"/>
    <dbReference type="InParanoid" id="A0A162WIY5"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="511"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="571"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="605"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="684"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1093"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1122"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1163"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1202"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1230"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1355"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="77"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="755"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD67445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1381" mass="156074" checksum="86A76B42CD93CC0B" modified="2016-07-06" version="1">MTKQSRMTQPNAPTDAEKGQSQDFDLTDFLRNVDDETSAAGIARKHMGVIWKDLCVKGLGADAKTISTNFSVIKTFVQFWKWGKTQGTDFTILKPLNGFCKDGEMLLVLGRPGSGCSTLLRVLANMRGSYTSIEGEVTYGGIEATEFSKYFRGEVCYNEEEDLHYPTLTTKQTLMFALKNKVPGKRVPGESSKEFINKVLYMLGNMLGLTKQMNTMVGNAFVRGLSGGERKRLSIAEQMTTRSSINCWDCATRGLDASSALDYVRSLRVMTDVLHKTTISTLYQASDNIFNLFDKVMVLDEGRCIYFGPTSQAKSFFEDVGFYCPSRKSIPDFLTGLCNANEREFRPGFEGKTPLNSAQFENTYLQSEMYREMMRERDAYESQIAKDRPDEHFRQAILEAHQKRAPKKSPFVSTYYQQVVALTIRQFQLIFGDVGALVSRYGGVVVKGIIMASVFYKMPVDANGAFSRGGAFLFSLLFNALIAQAELSAFMQGRRVLEKHKHFALYHPSAFYIAQVISDIPLAIIQVIIFQLCVYFIMGLKMDAGAYFTFMVVLVFTNLCMNGFFRFWGAVLPNFFAASQISSIFLIACLIYSGYQIPYKYMHPWLYWIYWINPLAYGYKALISNELHAMHFDCNGPAMVPYGPGYENTDYRTCTLAGANPGEPFVLGDSYLDRGYDYQVWQRWIDFVAVVLFFVFFTAITCLAMEYFGLQKEGSITKVYKNGKAPKAKTEEELMQQTGTREEEHMEAVSEGTTFSWHNIDYTVPIKGGKLQLLNGINGIVKPGHLTALMGSSGAGKTTLLDVLAKRKTIGKIDGSILMNGEPLRNDFERVTGYCEQMDVHNPNATVREALQFSAYLRQPAEVPKAEKDEYVEQILRLLEMDQIGDALVGDLEEGVGISVEERKRLTIATELVGKPKLLFLDEPTSGLDAQSSYNIVRFIRKLADSGWPVLCTIHQPSATLFENFDHLVLLMRGGRTAYCGEIGPGSATMIEYFESNGGPKCDPKANPAEYILECVGAGTAGKSKADWAEIWKGSKEAKALQDELNDILSKSSHDSSRKTSTYALSFWQQFMLVYKRMNISWWRSPSYNLGRLFNVCFIGLISGFTFWKLGNTPADMQNRMFSVFTTLLMANALIILAQPRFMQERMWFRREYASKYYGWGPFALACMVVEIPYLIFFSAIFLVCFYWTAGLENISDRVGFFYIHFFVFMLYSVSLGFMIAAFSSTPPMAAVINPFFTSILILFAGIVQPPSEMPYFWRSWMYWLDPYHYLIEGLVVDVMAGVKIVCGAGDYIKINAPPGQTCGDYFANYFESGGLGYIGNPEATGTCDYCQYTVGDDFYETRIGWSFSNRWRDFGILCAYYVFNVMLFTFFVFLFRKANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WLQ9</accession>
    <name>A0A162WLQ9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_67019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286955.1">
        <property type="nucleotide sequence ID" value="XM_018441724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WLQ9"/>
    <dbReference type="STRING" id="763407.A0A162WLQ9"/>
    <dbReference type="GeneID" id="29002630"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_67019"/>
    <dbReference type="InParanoid" id="A0A162WLQ9"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31964">
        <property type="entry name" value="ADENINE NUCLEOTIDE ALPHA HYDROLASES-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31964:SF113">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="31"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD68915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="180" mass="20361" checksum="3A361DA0E8CDCB72" modified="2016-07-06" version="1">MGTKDTNVDLSHTHDPEQEATKTRTAVISIDDHSDYVVEWALENFIRPETDMVVLIHVRHLDVPVAPYINPTGYIEDNDEVGRERSHRLLRGFAKELKKRNILCRAISIIGEPKTEILRKTREVKADVLIMGSRKLGTIKRTLLGSVSDHCVHHCTCSIIIASPKEAEEAPQKSHSFFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WVB8</accession>
    <name>A0A162WVB8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_171117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD71055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289095.1">
        <property type="nucleotide sequence ID" value="XM_018436514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WVB8"/>
    <dbReference type="GeneID" id="28997420"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171117"/>
    <dbReference type="InParanoid" id="A0A162WVB8"/>
    <dbReference type="OrthoDB" id="411871at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="617" mass="70002" checksum="13B75D0436D85D17" modified="2016-07-06" version="1">MGSFLGDHAITSRGTSFLQWIQATGLTCWNELLAFGIPTFLSGGSGTSRSSVIDLFLSTSPLLNPSMQIRSDLSLGSDHKMVNLTFTPYVSPPPPPTNHPRLLWNLSKLAQPDTLKIYIDTASASLDNLTEQFSAFLSSSSPPPVDSLCSAFAQAIYDALDTAVGRRTPRTMQKYWFWPVDLQEAMDLRERSYQRWRHSSGLQKAICWMRHQDACHAVRLSVQRRRRETWKEFCNKLATQDFAKTTATMKRIKSHRQTSPVFVDPGGPQADANKMADHLHQIFSGQFLPARRPPDQTVMISSPIAIDESCPFTHLSVESAILKLPTRKAPGVDHLRAEMLHPIFIRPQFEYGLAISCFNIKQVAVLEKAQNTCLRMIFGGHSTSSTSIFRHLGNLPSMRERILTLGFKFVYRAFWLPDEALFTLLRPVLTNPAHQWFKLLANPIWLSLSNRQNADSKACKHANRSFLNQGLFLQRSQQILLSACRPSLGVDPILWLPMTNYERSRFIRWRMGWLPGRPQPCSCGLHTTSRHHVIECTGAAIRLHLYSTVQPNPIDYVLNMLPLKKPKNNKNNAFWIFTWPILCRIMLDIEQICLSGVDLADHATTDRGQLFLNWLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WZ37</accession>
    <name>A0A162WZ37_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_147418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289705.1">
        <property type="nucleotide sequence ID" value="XM_018431860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WZ37"/>
    <dbReference type="GeneID" id="28992766"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_147418"/>
    <dbReference type="InParanoid" id="A0A162WZ37"/>
    <dbReference type="OrthoDB" id="2221454at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="45"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD71665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="672" mass="78347" checksum="F86BB6EA4B7E13FE" modified="2016-07-06" version="1">MTLARVTATHVYVPLIKLNKFVQKGIKFHLSFSFIVLIIINIVIIMLASHLPFEIVFIIASYLLTKDKLNCILVCKAWRQPLQDSLWNSLEITSQRKLNSICNTLKRKRSVYKIHGVYVKQLHMSGECRTTDQQLLRIQKSFQNLQRLYIGRFCLDGLNIGMQVGWTLWKSLTELTIDMHKTSVICEKEREKLFSCLPYLKRLCFTQRKNDPPLPFSLDNFEDLHDSLPRLEMLSLNIDLKCITENDQIRLWQVAPTKHMTKINFCARSMDSKWLCYFSLKYPDLNTLGLEAIENDKIPDFHKEEDLSVFSNLPAIFIHLKKASIRVRGCFERSHTVLWNLLSLHTVPVEHLTYRFDSPPYSPQLSSIVTRKCMISCSNTIKTLSIECRDDPFKPELIASVFKLCPNLVDLNIDIFLATIMLDTIIDLCVSLKRFRASNGSLELSKNEPRDPIMHGLRIIELTNTTAIASVFHYLSFHCRKLNYARLNTVKVISRLSNETGNCLVDMHYTQFKVLHIFYVQCFTSYATMFDAIGMNIMVLSKPRVSTDGHTNRRGPFLSQGTQSDTPTVQMWTHTYYERLKNRRWVPATRALMKKEVKFARKYYQDFERNKNIKNSLEVERSWTGELVWNNWKEDLCRGYFVLNCGPIDEYCIHQEKGCDPTLFNRIYSTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162X5T7</accession>
    <name>A0A162X5T7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_73924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290725.1">
        <property type="nucleotide sequence ID" value="XM_018442946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162X5T7"/>
    <dbReference type="STRING" id="763407.A0A162X5T7"/>
    <dbReference type="GeneID" id="29003852"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73924"/>
    <dbReference type="InParanoid" id="A0A162X5T7"/>
    <dbReference type="OrthoDB" id="3248986at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="54575" checksum="F8EC9E9BF2639BF9" modified="2016-07-06" version="1">MLTLNINWFQPFDGRTHSSGAIYLSINNLPRSERLKSENVILVAHFTVIDPMHNLYLGTAKQMIQIWRECNYINEKNQLTMQELANGIVVPCGYARIAKKIADGFSFMKADEWKSWCVIYSPFVLKHVLPAKNLENWILFVNSCRLLTKPSINDKEIDEAHSKLQLFCTRFQTLYGKSAVTPNMHLHLHLGKCVHDFGPIYAFWLFSFERYNGLLKNIETNQKGSFESTMMKRFLERTYIGSFIQSFVNHFPQFAIDFLHRISNSQDQLAALHPSSTASTFSLSDFVEYSLNPCHSALGCEPLPPSVFLIKLDQRITMCKGHYECLLEFYRHAYGSHDLFGHYSNCESNQIFEYSSGSYFRTYYLENNSEDKAAFPGRILYLFQHLLTINETVITHTFAFVEWYSSYSSGSYQPMLNEGIELWNKPSSVFNYECIIPVHCLYSPITIAKYRFTITSEFKRLVIPLPQKIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162X7C7</accession>
    <name>A0A162X7C7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_169195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290975.1">
        <property type="nucleotide sequence ID" value="XM_018436019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162X7C7"/>
    <dbReference type="STRING" id="763407.A0A162X7C7"/>
    <dbReference type="GeneID" id="28996925"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169195"/>
    <dbReference type="InParanoid" id="A0A162X7C7"/>
    <dbReference type="OrthoDB" id="2435739at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="184" mass="20607" checksum="722766937F69DB90" modified="2016-07-06" version="1">MKSASTTVPGFERVIASSPYAKLTRQRQSVELSPDVCKMLNNDRELRPQVRYFTAKVLSGAIIHNIFNSEAIMTNTIEPYGRTNYVDAHRETFGKEKNTAITTSIPPPTYTMYINVWLPCIGSKCMTFQLTTTADSMSTRISLNLTCLQEVFTTLASPQTSCISTSNIIYQLRQIRSNFSSPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XMM0</accession>
    <name>A0A162XMM0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_166951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293765.1">
        <property type="nucleotide sequence ID" value="XM_018435541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XMM0"/>
    <dbReference type="GeneID" id="28996447"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166951"/>
    <dbReference type="InParanoid" id="A0A162XMM0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="715" mass="81235" checksum="B19ECF9A1699D4B0" modified="2016-07-06" version="1">MFPSTQIHTLDCHCIKCHNSHQKSSYAAKRTKTRRNKRARVEAAMRNMDVDTEVIPTSRSDSVKAMDGQANSPFLDAASMFDNDRDDNDFDANVEDEVNEIEIEDFNSEDPFAAPDMPENEVHQFIAIFTVLFASRHVVDKGAAVLIEFINNLLRIYDQDFQLPTSLAGLQKMTGFSAITKGIKKFVVCQDCHTVYQDIVSAPPRCVSSKLGARSACNCNLTKSISSGALVAKREYVYQSIKNTLSVFFRRPSFEAKILRGTIIDPMHNLFLGTSKRLMDRWIDEKTIGPEEFASMEKIAETMVLPRDYTTLTTKIGKGFSYMKADEWKSWVLVYSPVLLHGILPPLQFKNWMYFVDACRYYVKPSITFDEITTSHSLLEKFCNACNVDYTATILTCNMQLHLHLHECIRDFGPVYGYWLFGFERYNGILKNFKTNGKDGFEATYMKNFVQNAYKGDYVNAVLKSSSQIPFIHTLSKLVTTSIPAATVTTLSSRPFRLQAFVQGYTDPYNPPKGNEPLPPSTFPLKYKKPSVMDDSDYLHLLEYYQVAYNLPDLASYQDTSYNRPALDNQIIKLKSIDILGQHYQGTNNSTISRGSLVQAKFVGSNGNIILGFAGQIQYLFTHSFQLPPTHNLHLTRMVHDHQHVFAFIKWFRTSSDRSREDDSVEFCLPTFSPDSYHSIIPVHRILLEVATATIATSRNVSKMLVIPLPKKLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y0B8</accession>
    <name>A0A162Y0B8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_60677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295585.1">
        <property type="nucleotide sequence ID" value="XM_018440683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y0B8"/>
    <dbReference type="GeneID" id="29001589"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_60677"/>
    <dbReference type="InParanoid" id="A0A162Y0B8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="148" mass="17221" checksum="CC82AFDE5CE0D8E6" modified="2016-07-06" version="1">MLNKIVYSIRKESLKTLIYVVFYKCCGTVISFTRPLQSDIPVRSAISTRNLGSEEYVIARVRLVRIIGEAGFLKNHQQLLFQCSSDRQAHVALFPSGPDCTWRHSVLFDGAGIMSWTYTILLVRVTLRQMNICARNIFRWQRRQRIMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y133</accession>
    <name>A0A162Y133_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_60917</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295835.1">
        <property type="nucleotide sequence ID" value="XM_018440719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y133"/>
    <dbReference type="STRING" id="763407.A0A162Y133"/>
    <dbReference type="GeneID" id="29001625"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_60917"/>
    <dbReference type="InParanoid" id="A0A162Y133"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD77795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="337" mass="37430" checksum="DD5AA27CCFBA3863" modified="2016-07-06" version="1">MPAKKKTARSPPKTFRCETIEGCDMVFTRSEHLARHIRKHTGDKPYSCPFPTCGRNFSRYDNMMQHQQTHFRTKKPAAPRKPTAAARKRAAAAAKKAQAALEAQQKKEADAAAAADADADADATCSCTDEASPPPPSALPAGPDPYYMGPNEHCHPLYHPMSGPNRILPPIHHILGYHEYIYPSRQIPVFHPSGDPYYLHGGLPSLASLFPRPITHQRPYWVESSAPPHEHLLGYDRRYSQPELYSRRMSWQYTPDRRSSAYSFQSSALGQLPLGRRLSSNDLSKPIVSLSVALMGDACLSEEEEEPATNGEVVVSTDEYQALEGMSRLSVSQPVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Z9C4</accession>
    <name>A0A162Z9C4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_176374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441030">
        <property type="protein sequence ID" value="OAD65181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283221.1">
        <property type="nucleotide sequence ID" value="XM_018437751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Z9C4"/>
    <dbReference type="GeneID" id="28998657"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176374"/>
    <dbReference type="InParanoid" id="A0A162Z9C4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22885" checksum="BF6D7EDDF5548D55" modified="2016-07-06" version="1">MNNTDNNSISLLHAMYNEILSLKAGQEKAKLEMKAQIEELKLEMKTSIEDLNLEITALQSQLENRNISNQHTSPSVSAISSANTIRKPVSIFREITLKHIFKMISEDLGIEVTSNEKATLNMCTKLICDDMAAHPSVITLGPNPSWGSIPVALKKEMCARHANIMKDSGIDFTRCLGNWASTARVAHLWRDRHKRLQSYFFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZK22</accession>
    <name>A0A162ZK22_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_160448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285381.1">
        <property type="nucleotide sequence ID" value="XM_018434181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZK22"/>
    <dbReference type="GeneID" id="28995087"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160448"/>
    <dbReference type="InParanoid" id="A0A162ZK22"/>
    <dbReference type="OrthoDB" id="2378895at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009792">
        <property type="entry name" value="TMEM242"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07096">
        <property type="entry name" value="DUF1358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="157" mass="17197" checksum="0C153A13550A66AC" modified="2016-07-06" version="1">MGAFGAGLMGAIWHTKRKQARDIAIEEAAEITQPPRTQQAGPAIRKPMPPRHIAHAPVAAYKPPTMTAAEYAIAKQDAGVFAFKTLAYGTLLAWGTAGVLALSVGYFLEVRNFKEFSDKLQIIVPRQTSRLRKALGGTSFEMREEETQELDALVLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZUX9</accession>
    <name>A0A162ZUX9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_116503</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287221.1">
        <property type="nucleotide sequence ID" value="XM_018428523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZUX9"/>
    <dbReference type="STRING" id="763407.A0A162ZUX9"/>
    <dbReference type="GeneID" id="28989429"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_116503"/>
    <dbReference type="InParanoid" id="A0A162ZUX9"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF28">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
        <property type="entry name" value="PPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="89"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD69181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="17687" checksum="6B8ADF7E5B24E8E1" modified="2016-07-06" version="1" fragment="single">MVRAIKWFKRMKTNGSEPDAYTYTSLIDGYMRIADIDKAESVFRSMMMNNVHPTLVTYNILMHHSVTQLDIKTAMSFWENLLQAGLKPDVYTFAILMHGLGEEGRVDEAWRLYNTMKEENVDINTHIATTLMGMHVKHRDNEHTIQLYRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AAM4</accession>
    <name>A0A163AAM4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TEA/ATTS transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">AbaA</name>
        <name evidence="10" type="ORF">PHYBLDRAFT_80026</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290221.1">
        <property type="nucleotide sequence ID" value="XM_018443542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AAM4"/>
    <dbReference type="STRING" id="763407.A0A163AAM4"/>
    <dbReference type="GeneID" id="29004447"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_80026"/>
    <dbReference type="InParanoid" id="A0A163AAM4"/>
    <dbReference type="OrthoDB" id="10006572at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050937">
        <property type="entry name" value="TEC1_TEAD_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041086">
        <property type="entry name" value="YBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF0">
        <property type="entry name" value="PROTEIN SCALLOPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17725">
        <property type="entry name" value="YBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00426">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TEA" evidence="9">
        <location>
            <begin position="71"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="7">
        <location>
            <begin position="71"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="290"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="390"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="538"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="424"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD72181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="753" mass="83929" checksum="F61F2D747C6A23CE" modified="2016-07-06" version="1">MLTCSQDMFFKNEQIQQQSRDQMSFPSIHKSSPMTAMSTFHSDCQLKDKRPRHPKKDYMVPHSNPALVNGKDKEEQVWPVDVESAFIEVYYLTRSLFLLFCSPSSLALETIPKLGRRKILVNGKPCGRNELISDFIFRKTSKIRTRKQVSSHIQVLKNTRKSDPHFMRLLTDSTDTKPNENYLQKKPTGLHPNAFLKNAINSQLGVSHGNSTVIFQPSESSSSDESSIGSSPSPADYVFDLMYGVDPNMSQNPLSMLDIKDIYSPLQQQSLFGMVDPLTTQQLIIQQNHHNNHNNHNSHNSHNNHNNHNSHNSHNSHNNHHHQQQQQQQQIQQQQDISTGNNPFFGTVAANFGINAFPSSSCLATNTPYPFTGSGVEAMSVDNMSSSCLFDFTKPPSRSKKNSNQNSNPKQQPIAESSISTLTSSSSSSSASSSSASASASSSSSSSSASSSCAHTNPNQKTDKNIITDQDKENDHLEFALWPNYLCLYLEYALPYDTSMTVSHNLAQLPHCYPNCLSTVDARSISREKCPLIGALTQSHHSQNSNNNNNKNSDSSNSSQQSSTSVVLLAKLKLDLNLNISDFVFNNTFFFETRDRRTIECTTTIYSFGNVVLESKEIQQALWLNEGKYMYSFVFVNQFFDAFMKGIRSLQSWEEVDIAIHNLCIVQVFEDMETKYNSTAPGTMDPSLVETNISPESCVGSSSRGRPSLLSMVYEFERGHGTIDMCAVGDAATNEKFGIGRGLDVLIDTKPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B4C8</accession>
    <name>A0A163B4C8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">tRNA:m(4)X modification enzyme TRM13</fullName>
            <ecNumber evidence="3 15">2.1.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHYBLDRAFT_80165</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 15">tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>adenosine(4) in tRNA(His) + S-adenosyl-L-methionine = 2'-O-methyladenosine(4) in tRNA(His) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43196"/>
            <dbReference type="Rhea" id="RHEA-COMP:10401"/>
            <dbReference type="Rhea" id="RHEA-COMP:10402"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74477"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43192"/>
            <dbReference type="Rhea" id="RHEA-COMP:10399"/>
            <dbReference type="Rhea" id="RHEA-COMP:10400"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15">
            <text>cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Pro) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32767"/>
            <dbReference type="Rhea" id="RHEA-COMP:10397"/>
            <dbReference type="Rhea" id="RHEA-COMP:10398"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the methyltransferase TRM13 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.225" evidence="3 15"/>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296261.1">
        <property type="nucleotide sequence ID" value="XM_018443562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B4C8"/>
    <dbReference type="FunCoup" id="A0A163B4C8">
        <property type="interactions" value="267"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163B4C8"/>
    <dbReference type="GeneID" id="29004467"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_80165"/>
    <dbReference type="InParanoid" id="A0A163B4C8"/>
    <dbReference type="OrthoDB" id="258806at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106050">
        <property type="term" value="F:tRNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007871">
        <property type="entry name" value="Methyltransferase_TRM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039044">
        <property type="entry name" value="Trm13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022776">
        <property type="entry name" value="TRM13/UPF0224_CHHC_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021721">
        <property type="entry name" value="Znf_CCCH-type_TRM13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12998">
        <property type="entry name" value="TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12998:SF0">
        <property type="entry name" value="TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05206">
        <property type="entry name" value="TRM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11722">
        <property type="entry name" value="zf-TRM13_CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05253">
        <property type="entry name" value="zf-U11-48K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51800">
        <property type="entry name" value="ZF_CHHC_U11_48K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="11 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHHC U11-48K-type" evidence="17">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="373"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAD78221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="478" mass="54483" checksum="02D5621FE67071E4" modified="2016-07-06" version="1">MPKESRSRSSKAGKTPAPVPPPPNKPQQCHFYVARKSRYCSLPAKRTNKFCGEHLAEQQKAGDTETLRRIPCPYDPSHTIFEINLEHHMQTRCNARPKEQEQFYSLNVNCTLALTQEELDFQKTIQSHKNMYSLPWIARIQLSKLQKEDMRSVAEKVEKVYKEYVPKIEQVILTNPATASPRTAERFVKHLDQQSSLLGHMVQRGMLDDKKACFVEFGAGRGELSGFLKKALDEKNGEATYVLVDRKNVKSKLDPFLKGTDATHSVVQRVLIDIKDLDLSKVQALMNENQEMKKVVVLSKHLCGSATDITLKCLMNYVTNQREAGNLKPISGIIIALCCHQLCRYEMYPNHEYLKQTNISRVEFDRLSKMSSWATSGPTYDPKKSITETENVPLTEEEEEELADHADAGQEEGDADQTSNHYSGWDSSEREKIGYECKRVLDAGRMRYLQEHGFKVELVYYVDPKTSLENCALIATPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BD10</accession>
    <name>A0A163BD10_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_61791</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298781.1">
        <property type="nucleotide sequence ID" value="XM_018440855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BD10"/>
    <dbReference type="STRING" id="763407.A0A163BD10"/>
    <dbReference type="GeneID" id="29001761"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61791"/>
    <dbReference type="InParanoid" id="A0A163BD10"/>
    <dbReference type="OrthoDB" id="128665at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="8">
        <location>
            <begin position="191"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD80741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="369" mass="42270" checksum="38505301421DD19D" modified="2016-07-06" version="1">METSNTDVESNYTDALNDMDSSSGDIEFYDCVMELNNNNVEVADKNSNNSRDFEISEDTTGTTDDYIEISDDEEDTIVNQNNEGDDDSCVFLYENITQQRLSHIQEDDVVDITEKMKIVSKAKAKELDRLRRSLNVIETSHHKKVAHTRDRYNRISKYNFQSYDMSRVCGSEVYKAYMRVKEYNSSLEKDVLTIHTAFVDGSLRFKKFGNMGRCFGGLGVYWGNNDPRNLSEPCGAEIVSSDGAELMAILRALQVCGDPTSSLRIESDSMHSILAIRGRFTIIDPVIRDILKRIKFQLNLRQAKVYFAKVPAHNGIPGNEAADKLAKIGSTTCMRRFEREYYKNSYKNPYDIPYKSPYKSPYKNFYPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BDJ7</accession>
    <name>A0A163BDJ7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_161507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298911.1">
        <property type="nucleotide sequence ID" value="XM_018434422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BDJ7"/>
    <dbReference type="GeneID" id="28995328"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161507"/>
    <dbReference type="InParanoid" id="A0A163BDJ7"/>
    <dbReference type="OrthoDB" id="3247418at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="716" mass="81587" checksum="945DFD7B4B238A50" modified="2016-07-06" version="1">MSTIPELYNEKCHCAGCSQNDLGYSFVARRTAQRHNKRARLNAIRCERDMSTQRNMMEVNDEPILTHQPGALEESYTQTNSPVWEGASMSDTEDVSVTNDAISNGDNDDSGSNSNEISEDESEDDVIELDDNELNSEDSFATPDMPQNPVHKFIATFVVMFASRYVVDKGAIVLIEFINKLLTIYEQDFQLPLSLPGLQRMTDFSAMTKGIKKFVVCQDCHKVYEESASVPSHCDFVKLGARSSCNCQLTKTSASGALVAKRSYLYQSILHRLGYLDLVRGTIIDPMHNLFLGTPKRLMDRWIKDEDIQDGDFAAMQKTAETMIVPGGYTSLNSKIGKQFSYMKADEWKSWVLVYSPVLLKDVLAKDRFENWINFVDACHLLIKPMITFDEVNTAHQFLQTFCTRCDELYNAEILTCNMHLHLHLRDTIRDFGPVYSYWLFGFERFNGLLKNLKTNRKIGFEETFMKKFIEDVHKDDLVNSFLQSTRQTSAFPLLTKLTSSFTPATIPSIRQRTFHIQSFVEASEDPNVLVKGNEPLPPSAFPLSLKSATTMTSESPYFVDNIITLLKYINILGQVYKSKGESGSRGSLVQAKFIGSTGEHIIAYTGQIQYIFTHSFTPPPTSSFLTPLLRTHRHPTQLLHNSQHTFAFIKWYTPENDKSREYEHVETCFPTFSPDDFQCVLPVHRIMLEVATAEHTTRRKVKKMLVIPLPKKQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163CRI7</accession>
    <name>A0A163CRI7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_153817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441034">
        <property type="protein sequence ID" value="OAD65080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283120.1">
        <property type="nucleotide sequence ID" value="XM_018433267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163CRI7"/>
    <dbReference type="GeneID" id="28994173"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153817"/>
    <dbReference type="InParanoid" id="A0A163CRI7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="289" mass="32944" checksum="663153D9042D6563" modified="2016-07-06" version="1">MQFVESACHIYSQSSLLLLGRSTFLITLSLSHMRRVLHVTIAHIKFFDKLGSIMRQFLHQKILPMASLASLCFPWTQDELGILNPQFQIPTKSLYQAMVKALYISTSVLLLFHSTDTTQSSSCPNTRRYSTTFVVSTSATPSFFVLSTMKPIPRNFSFVTVGYFIFVILLDLEAVRPRSPNERNSSPYLISKLTLGTHSFCAICRNPFKALLASLPLTPRQWCTFWSFPIPHSSDNIWYRTILNTLSFQITLYHHASALFDTVVYTPQLSEVHTRRPNTGYLLLMNLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163CS32</accession>
    <name>A0A163CS32_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_153708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441013">
        <property type="protein sequence ID" value="OAD65190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283230.1">
        <property type="nucleotide sequence ID" value="XM_018433232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163CS32"/>
    <dbReference type="GeneID" id="28994138"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153708"/>
    <dbReference type="InParanoid" id="A0A163CS32"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="237" mass="26213" checksum="578583394F95E3EC" modified="2016-07-06" version="1">MFSGIESTTGRIIHSDIYGRWVNVVLCSQISCRHDTSVHHQYGTIMDCECEGDRDLAFLKGLGFCKCNLLPLLNNLLCFNVIWISGAFTTFNCMAKDAARFAKRNAFFNVKQDSRRIDGTSPCSECKIHDHILVKFVSSESMQRFVLLMWCCGLVLSVILISVKILFTLWITVLSDAKTNVPAISVGTLEQPEAENISAGNQTTVEACMANLANSECEAEASQVSRTLSEDSGIPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163D4P3</accession>
    <name>A0A163D4P3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_63384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286750.1">
        <property type="nucleotide sequence ID" value="XM_018441115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163D4P3"/>
    <dbReference type="GeneID" id="29002021"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63384"/>
    <dbReference type="InParanoid" id="A0A163D4P3"/>
    <dbReference type="OrthoDB" id="4368495at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="107" mass="12106" checksum="D516CF370A15288B" modified="2016-07-06" version="1">MAQWTRRLTTNQEIPGSTPGSLIFLVFNYVVLNFGDIVRVDIGNQNRDLQATITSARKEIPDRDLTISSSNLFLLCPNSCQPIRMTITQNSLLRTMTEVISFCLQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163D6D2</accession>
    <name>A0A163D6D2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_160042</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD69070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287110.1">
        <property type="nucleotide sequence ID" value="XM_018434105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163D6D2"/>
    <dbReference type="STRING" id="763407.A0A163D6D2"/>
    <dbReference type="GeneID" id="28995011"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160042"/>
    <dbReference type="InParanoid" id="A0A163D6D2"/>
    <dbReference type="OrthoDB" id="198787at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal" evidence="7">
        <location>
            <begin position="66"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="8">
        <location>
            <begin position="209"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD69070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="32561" checksum="B5F4CF145B5F830E" modified="2016-07-06" version="1">MTTTPSERFGVLPKIELPACLEFLKLKNFPLKTYPSVYQPPRLTKDTLYIFGPGWRNTWGSFDAECLQFQIYLKFAGLEFDVINSNEPDASPSGKLPFLATVPGAIYHDQQIHKWIDDMGKSQVLAGEHSEDAKAFISLANTKLNAALIFSMWLEPLNYSKATSEAYFGHVPAPVDYILAYKKQNKVVQQLLADRDILVREEIYSDAVHALEALSVKLGEATYFFGSSDPTWVDAVIFSYIHIILGAPQFTDSSVSDEEKRQASTLRNLVLKHDNLVRFAKNIREKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163D898</accession>
    <name>A0A163D898_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_149269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287520.1">
        <property type="nucleotide sequence ID" value="XM_018432245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163D898"/>
    <dbReference type="GeneID" id="28993151"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149269"/>
    <dbReference type="InParanoid" id="A0A163D898"/>
    <dbReference type="OrthoDB" id="5596610at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="85" mass="9982" checksum="90866777E9C2D062" modified="2016-07-06" version="1">MSTERCHKKVRFSCDVEFISTFANEEYDRTAQEVAKLSYTDMYELLTLKAEWRRETEQVEKQLTKPAPEQQKPCVISQTACEICI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DI89</accession>
    <name>A0A163DI89_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kynurenine 3-monooxygenase</fullName>
            <ecNumber evidence="10">1.14.13.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Biosynthesis of nicotinic acid protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Kynurenine 3-hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BNA4</name>
        <name evidence="13" type="ORF">PHYBLDRAFT_134907</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:20545"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the aromatic-ring hydroxylase family. KMO subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.9" evidence="10"/>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289450.1">
        <property type="nucleotide sequence ID" value="XM_018429683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DI89"/>
    <dbReference type="STRING" id="763407.A0A163DI89"/>
    <dbReference type="GeneID" id="28990589"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_134907"/>
    <dbReference type="InParanoid" id="A0A163DI89"/>
    <dbReference type="OrthoDB" id="10053569at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004502">
        <property type="term" value="F:kynurenine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070189">
        <property type="term" value="P:kynurenine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000129">
        <property type="entry name" value="Kynurenine 3-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01971">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027545">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028:SF2">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0274">FAD</keyword>
    <keyword evidence="2 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 10" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="9"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="315"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD71410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="497" mass="56232" checksum="8A0383825E95BC71" modified="2016-07-06" version="1">MSDIKHPATVAIVGAGLVGCLNAIYFAQRGWNVVLYEHRKDMRLPEEKINQRGRSINLAVSERGLSALRKVDMGLEEIVLGAAVPMRARMVHLGKDTQTSQAYSVHGEHINAVDRGRLNELLLNVVGDLPNVRLGFEHHLLHANLENGTMEFSVGPEKIKVFKTADLVIGTDGAYSKTRSQMMRSMRMQYSQEYIDTAYCELSMPPAKDEQGNDTYALDPNHLHIWPRHTFMLIALPNLASTFFFLFFFFLDHSFTCTLFMPFEMFESINTSEKLLEFFQENFPDSIPLIGTKRLVEDYFANQKGSLINIKTSPHNFKDKALILGDAAHAMVPFYGQGMNCGFQDVEVLHEILDKHNVLPSKHENGKIDDLEAALDEYSRVHVKDTHAICDLALYNHYEMQSAVTSVRYLARKKLEGILHIVMPRVVIPLYTMVSFTTMPYSQAIQRWNRQSFWLNTIVGTMAIGTVTAMSYFTVKNKVSVSVPDIIQSVAQLSGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DMV4</accession>
    <name>A0A163DMV4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_65535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290460.1">
        <property type="nucleotide sequence ID" value="XM_018441477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DMV4"/>
    <dbReference type="GeneID" id="29002383"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65535"/>
    <dbReference type="InParanoid" id="A0A163DMV4"/>
    <dbReference type="OrthoDB" id="2260752at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="739" mass="82855" checksum="635852643C14EE0C" modified="2016-07-06" version="1">MLLASAEEDLNTKKGNYYAALGHYLGVSKRDPISTAAKSASKGAKEAQVLFAEAEQILKDLKASTAPASKPHDKRSTLVPSNLPFLQLRSEGPLVKANRDVFDSVYDFCQEFTTVLEAHSLSLDSCWERLLPTCLNKEERSWFEDKLKGKAYNWKKAESILLDHYDTPFRKFLNMGRVWCMKQGKGESARSFGAKFQKFRHQASLDDGVQLVLCFWWNLRPEVREACLIPLSANYGTKMPSKIEDIILLVSVSTSDSTALLHNPANGTAASSWSSFAAHNGASSLSAGSHKGKKRSFSRKRGSQSPKKSWDFKKAMKNGICFSCKAPWVKGHSCLEREKYLTKVSRMAVRSSAGRPARASTVVEGSPSLSWSEYQDNTSALAKMALDCKYNLKDMVIKRDFKNMSTNITFPILANNSIRTISLLDCGATFSSVDKNFCLKNGIAISYINHINKDLLNKNNVHKYFIRLADSNTQIKRIGTCVISVTCNSKTIQREFEVMNLTNSHEYDFSIGTDYMSSLGIGIYGLPLSYNDADSSEERREADRRFNNKSDLLESIERENERKENNPAVGPKQFEDAMDYIRPFIKDNQDIPKGSFCTIPESVVCLDTPENATAFRSPYPIPYKMQGVVDEQVKEWLDNGIIERASANTQWNTPLTVVKKTNGKGEITGYCVCHDPRLINCLLKSIDRMPLPLIGELFEDLKVNVARLVNTCVEIVIFFNSVCFFEVQIKDVVLVGFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DRY1</accession>
    <name>A0A163DRY1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_65021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD73050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291090.1">
        <property type="nucleotide sequence ID" value="XM_018441389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DRY1"/>
    <dbReference type="GeneID" id="29002295"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65021"/>
    <dbReference type="InParanoid" id="A0A163DRY1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="150" mass="17935" checksum="49F9B6EA008EEE0D" modified="2016-07-06" version="1">MNISMMLWKLRARICKRSLWSFTINSLIYSDDSQPAVFQKRNVVICLQGVIDCLHSTFIRFSHTKILIILKKSPPHSNIDQLKKISNKLQKIKDIIELNFYYYYYCYGSLVLVKILNFENETPIKKYIRVFRFHEYKSDVYPRILNKSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ECK3</accession>
    <name>A0A163ECK3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_68542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296000.1">
        <property type="nucleotide sequence ID" value="XM_018441970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ECK3"/>
    <dbReference type="GeneID" id="29002876"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_68542"/>
    <dbReference type="InParanoid" id="A0A163ECK3"/>
    <dbReference type="OrthoDB" id="10619663at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD77960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="143" mass="16476" checksum="65C448DBE7555EA7" modified="2016-07-06" version="1">MSHSTKSHKLLYNHLKKKNTEIPISTVIYINIAMIEEIPCLIDEFGVVVEPAMLIEYEDDEDEGEGEEEDDEITLENYLWSYTEKLLFDELPQIPEEDPADCEEPDTSPETSSTKLYTSNFCHPYDSSVDLIVYPFSDVTMQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EDQ3</accession>
    <name>A0A163EDQ3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_73606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD78100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296140.1">
        <property type="nucleotide sequence ID" value="XM_018442886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EDQ3"/>
    <dbReference type="STRING" id="763407.A0A163EDQ3"/>
    <dbReference type="GeneID" id="29003792"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73606"/>
    <dbReference type="InParanoid" id="A0A163EDQ3"/>
    <dbReference type="OrthoDB" id="2447509at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="198"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="378" mass="43496" checksum="0AEA34FA616F6608" modified="2016-07-06" version="1">MSSTQRHCAACHMLGHSRSTHKQCLMNPKNISLHIPQKRTNVDEYPAESSQTTALRIRSEPVQDQNLDIETLTFISVSELTEFPLANETITEVLEAVMEEEIEETSSDEEVTGREEEVEGQSIDLTLRLVAEGPRDQRRYNAPTASEIAVLSMNNEESTSRDIVLHTRANFQQSINDEDGWTIDASSLSGEHVTVMQWYSNCLMYRHNTQHLLHLFGRLFQQYIVDMYAKVEHNWLHFITSNQNRLHVDLYSGIQDAVIHNDCNLANLGKRVILPSSFIGSPRYMAQLYQDSMSIVRRFGKSDLFITFTCNSKWPEITNSLLAGQKANDRPDLCSRVFNMKLKELMIDLTKKIFWGKFWPLYMSLNFKSADFLMPTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EL32</accession>
    <name>A0A163EL32_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_139256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297260.1">
        <property type="nucleotide sequence ID" value="XM_018430188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EL32"/>
    <dbReference type="FunCoup" id="A0A163EL32">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163EL32"/>
    <dbReference type="GeneID" id="28991094"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139256"/>
    <dbReference type="InParanoid" id="A0A163EL32"/>
    <dbReference type="OrthoDB" id="5554140at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF1">
        <property type="entry name" value="RECYCLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="9"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD79220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="876" mass="99178" checksum="6C5CF531EF1E9418" modified="2016-07-06" version="1">MNFNNDTANKQSHSLPPNVLIRVFENLPISSLANVAMASRRFKVLAYDDEIWDTKLKIMLESDTGALAALLEDPNAKLSLIDKDTSFLINNKPLNTLIPGMSRDPYNERARAKSTGHARERFKELYIRIAPYYLDLRNINGKSKVLQDFGSAPETCGKTLNLLVGLGKCKVVDDWRELNDTVEALCQYFESASLHEFEIAYDSNKPAEMKVYAHAIIALNGGSLCIQTFLQKHPIFYDNPFKPEDNFVSSGLDIDSLKNLFAAITDAMKQQAELIIQVFPPSADVFYMFADRVFEDVMADYVTQLLGRAQTIDSSNYLYAISSILTLVYSLVDVITGDDVAIRIDKERGINLLYKLFFPLLDDYLEEEKKYVEKKYGKEIADWNQSSGERRDDPSVRLTNQSRELFKRNYLLAFKKVIALPIDLVSSAATTIASPFQRSMQFSFKSEDKTANKRASSTLASVESTSSSTSFSPQSTPPSTPKNSVSIPRHQKTNSTTSISKSPVNESSSLHSRQSSRNSIPTPTTPETKSLEPSDALENAQHELDALQNLLSLSVAVNMIHVNKDSERRVQRFINIGFPGRMKQDIQKTFEAIFINLLKTLGHDHIQTAFERASKRLLSYKPDPESLKFNNGEVPPLTEFFGMVHLADLMQHMIQAYYDEEITKYVDKHDFMNDINKEKKSFERLLDDCVAQGMDHGIQVLLAQVEMILSTEQKPEDYNPPSDIDVDLKPTKACFDAIECLKKNISMLSGAAEKSTMDLFFSEIGRRFFEVLCKHLKAQTVNEMGGLRYICDMNAYYAFAVDLKQRAITPYFSALKSLSNVYIITSPQDIKSVIHDLERYHGLMRIEDLFEFASCRADWPIIKKVVQKDMTDCSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EM30</accession>
    <name>A0A163EM30_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_139459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297470.1">
        <property type="nucleotide sequence ID" value="XM_018430230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EM30"/>
    <dbReference type="FunCoup" id="A0A163EM30">
        <property type="interactions" value="1050"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163EM30"/>
    <dbReference type="GeneID" id="28991136"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139459"/>
    <dbReference type="InParanoid" id="A0A163EM30"/>
    <dbReference type="OrthoDB" id="9993688at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="5"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="170" mass="18935" checksum="C31791A5E60B9D14" modified="2016-07-06" version="1">MPLSSMMVRIKREYKDVVNDKAADIEIEPGEKLGHFIATISGPRDTPYEGGRFKVDLQLADDFPFKPTKIKFITSIYHPNISSQTGAICMDILKDGWSPIMTIKASLLSLIILLSSPVPEDPQDAQVASHYLRDYDDYARTAAHWTAVHAIPERPKSPVTLESLLSPKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EMM9</accession>
    <name>A0A163EMM9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Lactoylglutathione lyase</fullName>
            <ecNumber evidence="3 9">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_184802</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-S-lactoylglutathione = methylglyoxal + glutathione</text>
            <dbReference type="Rhea" id="RHEA:19069"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:57474"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="4.4.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glyoxalase I family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="3 9"/>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297580.1">
        <property type="nucleotide sequence ID" value="XM_018438992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EMM9"/>
    <dbReference type="STRING" id="763407.A0A163EMM9"/>
    <dbReference type="GeneID" id="28999898"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_184802"/>
    <dbReference type="InParanoid" id="A0A163EMM9"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF30">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00935">
        <property type="entry name" value="GLYOXALASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="VOC" evidence="10">
        <location>
            <begin position="9"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD79540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="163" mass="18598" checksum="12947ABB3EDA65E2" modified="2016-07-06" version="1">MSTDPSKYVFNHTMIRVKDPKVSIKFYVDVLGMKLITKSEMEAGKFTLYFLAYVDKVPESEEEKRKLCFSMPGVLELTHNWGTENDADFAYANGNKEPGRGFGHIAVLVDDIQKACERFEQLSVKFIKRLQDGSMKHIAFIADPDDYWVEIIENPSIVGRAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ES68</accession>
    <name>A0A163ES68_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_72898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299250.1">
        <property type="nucleotide sequence ID" value="XM_018442741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ES68"/>
    <dbReference type="STRING" id="763407.A0A163ES68"/>
    <dbReference type="GeneID" id="29003647"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_72898"/>
    <dbReference type="InParanoid" id="A0A163ES68"/>
    <dbReference type="OrthoDB" id="2447509at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="36978" checksum="A121178C9BE69A66" modified="2016-07-06" version="1">MLSAEKCCASCKLVGHSRSSSSLCPMNKKKNTLNVPQKRTNEFIFIEEYSAESSRSAALRMRIEEEPVLITESVASPVNITSEGIIFEDKDIEEFELDEEIEEEEKEEEEVVVPVAVDNQGQMDVECQHCGALMWMNEKIGSSVLENIKFSMCCGYGKSYNSTLRFTSLGAKIDNLVANNIGGAYNFRIHRTVCHRMGSISPTSDQDLAHSKYAHLYIYDSQTQVQHHQCNAPYLNREIIEKIQSILLNINSFMSLFRSMNQISSHNGYMTDLTLRLIAEGPQDQRRYNAPTADEVAVLIMSNETASSRDIVLHTINNTLQNINEYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JIB4</accession>
    <name>A0A167JIB4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_175553</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441006">
        <property type="protein sequence ID" value="OAD66029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284069.1">
        <property type="nucleotide sequence ID" value="XM_018437518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JIB4"/>
    <dbReference type="GeneID" id="28998424"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175553"/>
    <dbReference type="InParanoid" id="A0A167JIB4"/>
    <dbReference type="OrthoDB" id="2276217at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007888836" evidence="3">
        <location>
            <begin position="19"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD66029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="379" mass="41405" checksum="D3BE4542A296457D" modified="2016-07-06" version="1">MLTISYFYFLLIVTGVCAEQATNWISVNCTWPCSDNKECIVTNKAIECQQVHNSQWVLSNPESSPVFRGETARLNQPCVVLPTPPLVPTTTDTSSSSSTVILWPPNDVSNPTDAYLSDCDNSTYCALESDMCIPRLLQNSVCVSTNQCIAGLICTSNDGTKTICSKPKHSSHDSDSKTKIGYIVAIVLGILILLILLGIMWYRRRRQRRMDTTKPSLVALETLPVAGAPGVQSQFQPSSYPHSSPHSPHSSYPHPTNASAGTGTTIINSTNSAFTFIPTSTSMHAHHPHHTLIHNHTPDANANTTPNVNATSTSTVIIGSTANHNDSNNDNSHNLPIYPDSSTPSMQQQQLQRQLQLQHHYNQPEADNKNTVPPPPYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JIB8</accession>
    <name>A0A167JIB8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_175561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441006">
        <property type="protein sequence ID" value="OAD66036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284076.1">
        <property type="nucleotide sequence ID" value="XM_018437520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JIB8"/>
    <dbReference type="GeneID" id="28998426"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175561"/>
    <dbReference type="InParanoid" id="A0A167JIB8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="104" mass="11878" checksum="042A49F748BFD87F" modified="2016-07-06" version="1">MSKFVLLLSIDKARFSVVIVNNRHMNNIVLVLIYKVILSKLSQKFKSSRSLFKQSFQVCVSTKSSRAQTASIVWVSEYLLCSYYCVTRKIVLQAVAIMALLRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JIC2</accession>
    <name>A0A167JIC2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_152842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441006">
        <property type="protein sequence ID" value="OAD66037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284077.1">
        <property type="nucleotide sequence ID" value="XM_018433010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JIC2"/>
    <dbReference type="GeneID" id="28993916"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152842"/>
    <dbReference type="InParanoid" id="A0A167JIC2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33324">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33324:SF2">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="316" mass="36444" checksum="D39CCE14A79F4EF9" modified="2016-07-06" version="1">MSNSNSEISLSTEDNHAIKNEYKTWYKHDGGKDGLTSMERLQQFMLMNGGENLNMYLGGDKEGRTFKSSKVIILNKCNQYFQEQGVYRTTAQRKSRLNNLLTKQYGEAYRVWNNSIKNNSNDEGSTSEKEGLESELNQICPAFFHMEKVMGNRKTGSPAVCDTTKPMEWIHDEDGEQSNGDDDNTDEESAENSHSSNNEEYDSQNDNMSVLCSPPPKSSSSRKCRRVDVEYKELAEEVTRQLNESSVSLEAKIERLYREKLEVLKDDLHIKREREFIHRKFENMMKAVAELAKVQNWSDEKVQEQTDDVYNKTYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JPC0</accession>
    <name>A0A167JPC0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_119261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441003">
        <property type="protein sequence ID" value="OAD66427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284467.1">
        <property type="nucleotide sequence ID" value="XM_018428675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JPC0"/>
    <dbReference type="STRING" id="763407.A0A167JPC0"/>
    <dbReference type="GeneID" id="28989581"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_119261"/>
    <dbReference type="InParanoid" id="A0A167JPC0"/>
    <dbReference type="OrthoDB" id="2283961at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="12068" checksum="B8DEDCAABFF43605" modified="2016-07-06" version="1" fragment="single">LLYSDAIISFSPTFDQHLKNFCKISFYLCTLVPKLMLIKCSFNRNWIYFLGYVLSPVGLHTDTEKIGTCFNFHIPLSADVRLLLGPTDYYLYSFGILFLPSLLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JXR2</accession>
    <name>A0A167JXR2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_152152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441000">
        <property type="protein sequence ID" value="OAD66888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284928.1">
        <property type="nucleotide sequence ID" value="XM_018432852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JXR2"/>
    <dbReference type="GeneID" id="28993758"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152152"/>
    <dbReference type="InParanoid" id="A0A167JXR2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="41368" checksum="26AE813723FAA92A" modified="2016-07-06" version="1">MPSNSSRKTDRKGKGKASASISTSANRVLAGHVGPREIAPSFSSATIQDQRYAEIVEMFNKVNNNINGVKDDIAAVNSNMAAFKNRMGVVVDTSGKTHTAFADFATAYANNQTCMASLGPSLMPSYVPQTSLSDAEVSVIISEIFAEKLWDWKFESDDPALVAENESKKKWNLNEKINHRDNVAVINYLKSYISAQTRLAGTHPRVISDKIKNRYKHSHRTFHESSEQKAKKNSKGRANSRTLQMSIRRKSTYMDNWVAIDAAMGYKTGNPVEKAYLKLFQKDAMSDGESDIEIVDNLPRRCLHVARPTWRSEEFNRLLTMVDDIDRTHHVLNAGVGTKPRMNRYPATLLPCSVPATLSQSLPRWAINDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JZL7</accession>
    <name>A0A167JZL7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_174686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD66979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285019.1">
        <property type="nucleotide sequence ID" value="XM_018437314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JZL7"/>
    <dbReference type="GeneID" id="28998220"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174686"/>
    <dbReference type="InParanoid" id="A0A167JZL7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="268" mass="30712" checksum="DCD8A77BF71AF145" modified="2016-07-06" version="1">MPIRMSITSNSFLRIMTKLKQMFSKFMNSDAEQQEFTKRELRDFEVEEVKFHLKSNDNEEVETPTLTRDLSLSEVDVVFGIEDNEYTGRNNFNNEEYETDGEMSDNEGAYSILKNMSILEFFFECVSKLDFVYRFIIVAITLFVSLYVIDEGVVILILIVNKILELFNDSFHLPLSVSGLKQLAGFGGLTKGIKKYTECGKCHTIYDNNESVSLCCTSPKFDGSSLCFTTLFKAGSKSRIPKKTYIHTAKTDQFRICKVYLSSDSQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K4V8</accession>
    <name>A0A167K4V8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_151541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285328.1">
        <property type="nucleotide sequence ID" value="XM_018432701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K4V8"/>
    <dbReference type="STRING" id="763407.A0A167K4V8"/>
    <dbReference type="GeneID" id="28993607"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151541"/>
    <dbReference type="InParanoid" id="A0A167K4V8"/>
    <dbReference type="OrthoDB" id="2281119at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="580" mass="65506" checksum="304206B3E30AF2D6" modified="2016-07-06" version="1">MKRTAWYPNSQRKRTIFTTASGSNNAVVEVLSSSSAEETSRKAQKDKQKVLTGERGQWDTARDIAIMQSIYDRHLFANYHGNKSLTSILKDSHKYSFLISNLQLFFLKTSSKLQPTQQLPPLLPPTFAKEDCSEDFLFSLPLKYIPGTDLMSKLILNNDEVIKIIVSTLFGVDACRKYSTRPKEWPNFKRSDVLYCPFNRKEFKNHPPILIEVQYYTGMNFFRRLMKYSLSVCKYYSTLPIVLTIVTNNISQALADQAYECPEFPYAKNLPCTGRTKACFMINKQTITNHLKSKPLEAMVALAHFLIEGKSALINIDRRDDQTIQTLYRIAKNIIFPEIEKEETNSAAFEKLYFCAFNGFNRTKEILLENQALNEIHRKRFAATSSDPTGTITPDQDTALTTISSETNVVSTSSPVNVSTMPKENDTTLTQSASSSAAIMPNASTVSVPISTSGTTRDLKRRMQQKNWKFINAYRTEHGSNMDWEQCFVQGKGKGLSTIYKSQEYESSIFSGYIKDFKSDGSGEVRLKNENLTSAGRGCLLGVSRLYLTGMGCTVVQQFKDLCKTYVSSYGPTTEVRTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KBK0</accession>
    <name>A0A167KBK0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein DOM34 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_136746</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:20890290). In the Dom34-Hbs1 complex, dom34 recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following ribosome-binding, the Dom34-Hbs1 complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285729.1">
        <property type="nucleotide sequence ID" value="XM_018429809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KBK0"/>
    <dbReference type="FunCoup" id="A0A167KBK0">
        <property type="interactions" value="530"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167KBK0"/>
    <dbReference type="GeneID" id="28990715"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_136746"/>
    <dbReference type="InParanoid" id="A0A167KBK0"/>
    <dbReference type="OrthoDB" id="10249111at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.870:FF:000001">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000008">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000002">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD67689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="387" mass="43778" checksum="08A4E291C26FE9C8" modified="2016-07-06" version="1">MKLIGKVLEKDASGQVTLYPEELEDMWHVYNLISKGDMIKATTIRRLQAETSTGSTSSQRIRLVLTITVETVDFDPQAGLLRINGRVASESPHVKMGSYHTIDLELNRNFTLFKPEWDTISLERVEDACDVTKQADVAAVVCQEGLANVCFLTQHMTIVRQRIEAPIPRKRKGSVANYEKGLQKFYDQIYQAILRHVHFDIVKAIIIASPGFVKDQFYTYMMDQAVKTDNKTIMENKSKFILIHCSSGHKHALNEVMQDPSIQARLADTKAAREVQALDKFYQMLNNDPDRAFYGFSHVLKANERGAIGTLLVTDELFRSADVETRRKYIDLVEQVRAMGGSVYVFSSLHVSGEQLNQLSGVAAILNFPLPDIEDEEEEEERLASET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KKY0</accession>
    <name>A0A167KKY0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_68873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286366.1">
        <property type="nucleotide sequence ID" value="XM_018442024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KKY0"/>
    <dbReference type="STRING" id="763407.A0A167KKY0"/>
    <dbReference type="GeneID" id="29002930"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_68873"/>
    <dbReference type="InParanoid" id="A0A167KKY0"/>
    <dbReference type="OrthoDB" id="2267579at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="251" mass="28903" checksum="0176A4393D85927C" modified="2016-07-06" version="1">MCTGIWLVEAVFVGFVDTAHRDKEILKDFDEPSAKGLKSNIIRCTKDTLQFEGGKWTKSGAINQIFVPDLKKYTMDAHQIVQGKYKDGDKLRIAGRAASEDFNDLKYIKSQQNSNKDASDFDELIEKVRRLAVYAFASGKTLDEDSKELSIRAIKLPTRARYREDEDDNDKDMAFDQEWVEKIQQARYEESVHQSAVLWGENKAKYNIDERIRENLCRLFISKENVCLSNLYHNESSSRSIVLLERSGKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KQ96</accession>
    <name>A0A167KQ96_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_173048</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286668.1">
        <property type="nucleotide sequence ID" value="XM_018436931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KQ96"/>
    <dbReference type="STRING" id="763407.A0A167KQ96"/>
    <dbReference type="GeneID" id="28997837"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_173048"/>
    <dbReference type="InParanoid" id="A0A167KQ96"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="121"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD68628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="418" mass="45849" checksum="42AFC56D80C8C0E0" modified="2016-07-06" version="1">MRPASIHSRSSSSSSSSAFSFGNEEKPISPSGSSGSSAFFSKLTSTVRDTRSKVEAKKTELNATMQEKLPEWKSRSVMYGNIARETGIEWGRRGKVAVERWKKEPLTSPSTPHLEHSVFGLSLSLAVSRTRIDPEDPVPAVFRRCVEYVDKHGIMEVGIYRISGSTSTVNGLRTLFEDGSDVDLEVTQPDPHAVGALLKMYLRELPDPIIPTDLAHEYSQVISEAIRTQEDVGKDTLSLTPALLKTMRNMTASLPRDSFHLLRLLCAHLRRISAQAATNRMTTSNLALIFIPTLGIGRHLFYCMVENPSLWDTSSSEIPPTPSTPPTPSSPSTPAGPVLTPPPLPQKPLHIKLHCSPSATTKPLPISTNPPPKPSRSPHHTKKGSPPISCSPPDRVWKRTHGTKVNAIGRQFETLMHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KRT2</accession>
    <name>A0A167KRT2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor E2F/dimerization partner</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_173148</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286769.1">
        <property type="nucleotide sequence ID" value="XM_018436951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KRT2"/>
    <dbReference type="STRING" id="763407.A0A167KRT2"/>
    <dbReference type="GeneID" id="28997857"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_173148"/>
    <dbReference type="InParanoid" id="A0A167KRT2"/>
    <dbReference type="OrthoDB" id="1743261at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000008">
        <property type="entry name" value="E2F transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015633">
        <property type="entry name" value="E2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081:SF18">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="7">
        <location>
            <begin position="60"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="124"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="259"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD68729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="354" mass="41031" checksum="0215A7CC011AFF2A" modified="2016-07-06" version="1">MRIRNTDMEDRGQDTKRYHTDKRDQEMCIIITGRQAGRQTAHFQINSSGSMITSNIQSCRYDSSLGLLTKKFVSLLQSSTHGDLDLNSAAAELNVQKRRIYDITNVLEGICLIEKNSKNHVRWTGSTPSLNSSSNNSQKNNYQHHLNHDYNDNNDNNRRLDQIDEDTTELYRLEQRLLTLKSNNNSLLNEQNHLAQLTLEVNGRIERECSYHRDYCFLTSEDQARLEKQPMSQTDTLLAVHEPYDALIPCLDNIAPHTYNHHNHNHNHNHHHNNSHSNTNHNNHNNSRSSFDRHRRQTSHIYPNHPYLPSTIENKHTVRCVVRVPDHSDQSLFGRLSDGHRNQSLSRASSFYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LK67</accession>
    <name>A0A167LK67_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_95526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288674.1">
        <property type="nucleotide sequence ID" value="XM_018443912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LK67"/>
    <dbReference type="STRING" id="763407.A0A167LK67"/>
    <dbReference type="GeneID" id="29004817"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_95526"/>
    <dbReference type="InParanoid" id="A0A167LK67"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12363">
        <property type="entry name" value="RRM_TRA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD70634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="86" mass="9983" checksum="1FA80D35C1AD3E26" modified="2016-07-06" version="1" fragment="single">SNILGVFGLSLRTNERNLEEVFERFGKLKKVTVVYDHRSNRSRGFGFITFGSVDEAERARDETNGLEIDERKIRVDFSMTHRPHTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LKW5</accession>
    <name>A0A167LKW5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_159578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288708.1">
        <property type="nucleotide sequence ID" value="XM_018434010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LKW5"/>
    <dbReference type="STRING" id="763407.A0A167LKW5"/>
    <dbReference type="GeneID" id="28994916"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159578"/>
    <dbReference type="InParanoid" id="A0A167LKW5"/>
    <dbReference type="OrthoDB" id="2436262at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052455">
        <property type="entry name" value="Tricalbin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980:SF2">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="122" mass="13909" checksum="47FDCB6E8ECAA365" modified="2016-07-06" version="1">MEGSVMINLIEARGLRGVDKSGTSDPFVRVRIGKTQAYKTKYIKKTLAPVWNESFKYSVPSTPISIDFKVKDYNRFSSSVDLGECQWNLWSLVRPEQSTIFEGWLPLYPTGSGEIHVRIEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M464</accession>
    <name>A0A167M464_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_170400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289779.1">
        <property type="nucleotide sequence ID" value="XM_018436329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M464"/>
    <dbReference type="GeneID" id="28997235"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170400"/>
    <dbReference type="InParanoid" id="A0A167M464"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="111" mass="12924" checksum="523D5C10B547A7D6" modified="2016-07-06" version="1">MNSQLDINMLNIIRIVIWEELADIYTSVARIDKNVANQQQFIRQTFNADRTNVIEQSVIKRQMTYLVSHSDDRGERSAEPAQGNSVNYSISEEESIVVITQPWRPKRSRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MA54</accession>
    <name>A0A167MA54_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_181764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290289.1">
        <property type="nucleotide sequence ID" value="XM_018438518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MA54"/>
    <dbReference type="GeneID" id="28999424"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_181764"/>
    <dbReference type="InParanoid" id="A0A167MA54"/>
    <dbReference type="OrthoDB" id="8757000at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF5">
        <property type="entry name" value="F-BOX AND LEUCINE-RICH REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="634" mass="73752" checksum="E40BD592601BC931" modified="2016-07-06" version="1">MTISKIPPEILTSIAMFLSKRELRQSSLVCKQWRQPFYEELWRTVRLYNEAAINAMLCLHSQNKYMTYGQYVRNLFISGETPVSRGNILVLQQLFPNTRHLDIALSYPETTDISINWSVWKSLTELAVDFQYYIDSSVMTSCSVILSHLSYLTTLGLVFGDTYTSRIGDFEAIHYYLPYLKSFSIKLKSVRVIEKDIKLINEAVPANNVWKLSITMDMQDLQWLYYFAVKYPNVREMTLYVIGERDYLKDCNLAVAKSRISSLPHVFPSLDKLTLDNSAHATLFPLAFYQCFYDKTLSIKEFIYQFYIMPNEERIVERTTREFMRVSSKTIESMTLSENDYMECSNPRDLTTLFTDCPRLVCLHFDNCGSCLKFDTIADCCPSLKELKLYRGGVYIGPEAIKSFKPHGLRILNLKEASIDPDTLKYISVRCVSLSHASFHRLVVFGTISADTGNLLIDMSNARLTELLIDGLFYRAPEAVGLWYPITKIDLMKLVRLTKPYPQTGERYEQTDQYSANHVSIYETETTWYNVFTCAYWSAPSDVYMLKQPEVDFIKEYFENYRDNMLPDKMQDICISKKNQYGIQYDVYPGRGYVTFMCGYAENSYINMEYRRSLDGFKWNSTKNMVEYLGKSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MJJ6</accession>
    <name>A0A167MJJ6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secondary thiamine-phosphate synthase enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_134122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD73019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291059.1">
        <property type="nucleotide sequence ID" value="XM_018429621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MJJ6"/>
    <dbReference type="FunCoup" id="A0A167MJJ6">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167MJJ6"/>
    <dbReference type="GeneID" id="28990527"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_134122"/>
    <dbReference type="InParanoid" id="A0A167MJJ6"/>
    <dbReference type="OrthoDB" id="10255963at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047_YjbQ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YJBQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615:SF8">
        <property type="entry name" value="UPF0047 PROTEIN C4A8.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01314">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="15854" checksum="DE76F41A24D3D0ED" modified="2016-07-06" version="1">MSWYQKQIKLAAYPKGCHLVHQEIVSQVPEIKQYKVGMANIFLQHTSASLMLNENCDPDVRTDMDMALDRVCPDNLPYIHTDEGPDDMPGHLKTGMIGVSLNIPITNGKLNTGTWQGIYLCEHRIYGGSRKIVVTLQGEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MR70</accession>
    <name>A0A167MR70_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_71810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291684.1">
        <property type="nucleotide sequence ID" value="XM_018442543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MR70"/>
    <dbReference type="GeneID" id="29003449"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71810"/>
    <dbReference type="InParanoid" id="A0A167MR70"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD73644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="379" mass="40574" checksum="59984B42C3859B47" modified="2016-07-06" version="1">MLSVLHLKTFVTNVICNNQVDQEYPSDYANSHNIRRFRIGFKGVELAIALFVPRNLCTTQGPYTICWPTPETFIAHSVKVSFYVLVAALLTLSFIISCLFYAAKHLVGSYKNRSKSSNTQINQLTSTLSTPVVIPASSEPSSSVELLKPNKTLLVPETSSSSTGYSNPTENLPSYTHSPSNAASHTDQRKGQIWTSAAGLAVSAGSSPVDSSPNSIPIQIVTDDQVKSSLGDGPVNTVDDSSVSHISDNIPYQPVDDAPAESFFNDDPVKTVDGISVALTSSDSTIQAEDNSSVDHTSNNSPLQEVDDTPVDSNDNSGIVQMVDTSSVDDTSVDSDANNEPVQAVEDSPIAHNINSSPVQVVDNNSEESTARIRQINPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MX47</accession>
    <name>A0A167MX47_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_67714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292404.1">
        <property type="nucleotide sequence ID" value="XM_018441839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MX47"/>
    <dbReference type="GeneID" id="29002745"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_67714"/>
    <dbReference type="InParanoid" id="A0A167MX47"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="168" mass="19317" checksum="AB253DD55ECD5774" modified="2016-07-06" version="1">MTGSNKSYSDLDQLLFQLVELFLKEAEGDRSKAMKKQLASEEEVQKQAAADKVVERATLLKSNNPLRVVEQKKCTDKVEGSSSGHLVDQSMANFSDAREMFKSFQNELSSMVTGISDGEVLTLMRRLEKNVERGFLAIETRQRTLEQRQTLLEERQARFKYNMQRYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MYK4</accession>
    <name>A0A167MYK4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Signal recognition particle subunit SRP68</fullName>
            <shortName evidence="10">SRP68</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_181257</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SRP68 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292569.1">
        <property type="nucleotide sequence ID" value="XM_018438439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MYK4"/>
    <dbReference type="FunCoup" id="A0A167MYK4">
        <property type="interactions" value="807"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167MYK4"/>
    <dbReference type="GeneID" id="28999345"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_181257"/>
    <dbReference type="InParanoid" id="A0A167MYK4"/>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038995">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0733">Signal recognition particle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD74529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="605" mass="69242" checksum="BC0F89CD700BFA8B" modified="2016-07-06" version="1">MAEPMDLEDSSKSPMSVDVLHIINEARMTYGLRHQDYQRYRKHCAHRIGRIRQLLHIGQDMTKKNAQRKEIPANVDDKRYLELYIYEAERAWATAMELKAEAESSMGTRKRHHFTQKLKKAGQHTDALYALCQKLSVDSITVLNIKAYAMTMKGYYYIERKQWQDALDQCVSARSLYETLAQTSSNAHQEALYYSAIDTLDPNIRFCAYKLQIDTSSQDMDAITKHIKPVTGMESLETELAKVKETSGQGQHDQQNFLNRRISQTINWRSKTLTVKNKNLADPIQKAEDSVRHLDTTTTARSENENKTVESFDPILSHWAEAEKQARKTIKEDKEVSAKVTSSKSVQASEELVWIQAFVIYNLYARSIQRNLVLVEELKSTRGKERELIKLYDDILKNVDSIRDLNVVQEDAAFDLELDTLAHFYRAHRCVYVARIYAEKAMTPEALSLYQRSQLYVVQAKQGLQQLGGQFSEDAILKVSDTELNSLEQTIRTGTHKAHASWYLEHPTDSEDYENDLTHKMNHLNLDKQGETALINRLDVYPATLATNTGSAPHLIDFPPVFQPVACKPLYFDLAANQIKYPSALTERADKPASKLWGFFGFGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N551</accession>
    <name>A0A167N551_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBZ4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_144372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293060.1">
        <property type="nucleotide sequence ID" value="XM_018431202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N551"/>
    <dbReference type="STRING" id="763407.A0A167N551"/>
    <dbReference type="GeneID" id="28992108"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144372"/>
    <dbReference type="InParanoid" id="A0A167N551"/>
    <dbReference type="OrthoDB" id="5576441at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21541">
        <property type="entry name" value="BTB POZ DOMAIN CONTAINING 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21541:SF3">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="47388" checksum="2E486FA0F4F5C6C1" modified="2016-07-06" version="1">MSSLLPRKKRILSLRRDRTQSVLTLEPIKSTQEIPGKTSPPPTPPQSQSQSQPQPQPQPQSQSQSQSQSQSQLQPQPQKLPPLEPAIEPHPPVQLPTNEESYSCPICDKDLSCTRSSYLRQQHVNKCLDSPTNLPITKDQSPFDYCIFCGKHISALNSARKDAHFNRCLDDIAREEKESNDAANLAIAAKEAPYLSRLDLCPCCYETDLFRNYNIKRKIAHVKQCAKRRSMTLPQLLQQCRWLGWGHTPVPVAQPPPPSPPCTAKTSLKRTINFAVVEDGSEDFKETVLMYRKPHPLFKKSTKDDKKDESLQTALALSLSMKPSIVKKKGRPTEYDHNSSNILTVEESRRLIADALDNMLSSLPHPCEKDFLAIPPSKLKTKTIEHTQERCLWNLAVYRNVPSSKEIYISKIIKPDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N7D2</accession>
    <name>A0A167N7D2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_72015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293260.1">
        <property type="nucleotide sequence ID" value="XM_018442581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N7D2"/>
    <dbReference type="GeneID" id="29003487"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_72015"/>
    <dbReference type="InParanoid" id="A0A167N7D2"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF489">
        <property type="entry name" value="RING FINGER DOMAIN AND KELCH REPEAT-CONTAINING PROTEIN DDB_G0271372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="159"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD75220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="477" mass="55434" checksum="4D130F4D18CBBBEF" modified="2016-07-06" version="1">MNNTDQQILGNTSHYKYPIHEWSNIPLFSNIYSPHFYTQDYTCLKKGSKEAPGSLIVATRLALSDNSAKPYEIMITFSIKKKSDTSKSTRRNGLVLESNILEGLHAPITLKALEPYIYDDCLNVVVSIDKLPRLLGMFGKYPPGHGFLLVVYDDLRPSPNVIIRVSKDEKETENVTSEAQIYYSNKHILIKNSAWFSNMFLSGMRESEDSRITIRGVDPQIFGRILHFIYTQEIPIESMKDSIDIIKVADRLQFDKVNTKAFNVLKDGISRHNVLETWRCKYLRVQKRAYTPIDQYEYTEIQDLCYKYMRRYCGDILKSPEWLDTDGQQATKILKIDCLDIPVDETIFFEAVINWRKANITRANRLYEDNVSNLCSEPSADNKVVYNCENEFRGADSKLQEKFHKKKATLLKEIDYYFAEMVRSVRFTQIKKEYLAETVQQECSVRDVYGLHFLLRMAYKNLAFSKGIKLEKNYGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P7Z3</accession>
    <name>A0A167P7Z3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar ATPase assembly protein VMA22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_141319</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295471.1">
        <property type="nucleotide sequence ID" value="XM_018430564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P7Z3"/>
    <dbReference type="STRING" id="763407.A0A167P7Z3"/>
    <dbReference type="GeneID" id="28991470"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141319"/>
    <dbReference type="InParanoid" id="A0A167P7Z3"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040357">
        <property type="entry name" value="Vma22/CCDC115"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21730">
        <property type="entry name" value="Vma22_CCDC115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00093634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD77431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="235" mass="27073" checksum="D5D1F11196843D61" modified="2016-07-06" version="1">MAMTEQLEKVCLQLDDLALQYLSKLEEYGREWETCSSDFQQGYLDLAQAKYTMGFTTISQSSYDERMKALLRMHIENNTFSISKPPEHPVESETNLRRRTAPTTSTSTSASTSTSSSASSSSSSNININNTNTNNSFSTKKKDSEWIEIERELELPEEYEMNEKKPEKPKKPNNDPLRWFGYLVSPSLRTSQKHFKTATMRIIEQANRMKELKCLEEEYNALQKKKILLLDQSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P965</accession>
    <name>A0A167P965_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_60632</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295539.1">
        <property type="nucleotide sequence ID" value="XM_018440670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P965"/>
    <dbReference type="FunCoup" id="A0A167P965">
        <property type="interactions" value="615"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167P965"/>
    <dbReference type="GeneID" id="29001576"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_60632"/>
    <dbReference type="InParanoid" id="A0A167P965"/>
    <dbReference type="OrthoDB" id="422427at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048624">
        <property type="entry name" value="CSN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21151">
        <property type="entry name" value="CSN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="249"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD77499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="462" mass="52186" checksum="714CA406BDADF15D" modified="2016-07-06" version="1">MAKFTEDPLLDLAVKERNIFDFLLRSLIITGIITTMSESLIGHQNHLDLESYIATYQGHTRIARALFIAAKCPSLEIDAYRLALSDIKEITNDTTKYLHCVDELNNALKKQNSHPMEIDTEWVKSTQISNKKTMEQLQSELRTYKAGLISESIRVTQTRMGDFYYACGDIPNALKSYHRVREHCASNKHVIEMCFNVIKANITANNFASVRTYIARAETTPDLPNKTITLAKLKCCNALFLLSAEEDAKYGTVAKALTEIPAEANGSFSDIISPNDVAIYGGLCALASFDRSQLRSLMVNQGFRSYLELEPQIRDIIEAFQDSKYSACFDLLSSYRNDLLLDMYLNPHVDILFGHIKEKAMVQYCAPYSTVDMRRMANIFKMSVDSLEDDLVSLIGDSDRISARIDSYEKILYTVRPESRNQAFKRSLRAGKEYERSTKALMLHLNLVSKELCSGGAESSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PAL0</accession>
    <name>A0A167PAL0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_164482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295617.1">
        <property type="nucleotide sequence ID" value="XM_018435012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PAL0"/>
    <dbReference type="GeneID" id="28995918"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164482"/>
    <dbReference type="InParanoid" id="A0A167PAL0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="172" mass="19989" checksum="21B4926ABA3A0B84" modified="2016-07-06" version="1">MTFSLFYLLIFPESDNTSWDQIELFHAGKKVKICGPLESKWYLPPGNFVSLELANIDTVHFECKSKVDKILRSEHTGITDGCLFLIYKISIGKVTFALMVKIILWLRKMNSRFGNQNDPDYDDFDLSVHTDYMYKAKKENKFLIGWPSSFVPREIRLNRTLNVVGPIDWRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PC78</accession>
    <name>A0A167PC78_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_108869</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295688.1">
        <property type="nucleotide sequence ID" value="XM_018428075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PC78"/>
    <dbReference type="FunCoup" id="A0A167PC78">
        <property type="interactions" value="271"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167PC78"/>
    <dbReference type="GeneID" id="28988981"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_108869"/>
    <dbReference type="InParanoid" id="A0A167PC78"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="7">
        <location>
            <begin position="153"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD77648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="282" mass="32891" checksum="A0C4CC3235FEE7B5" modified="2016-07-06" version="1" fragment="single">IERLKNEVVIVSSNVDEIDQLHNSSIASYNEQQLKTISEQLQRLKTQTQKLNLDIKNRIKTVETANAHFPNSSDAQIRRTQTMTLRKRFIDTIQRYQDLERSYEQKYRQRVERQIRIGKFEEVDQLIGSNETPQIFAQSIMQAGRRGQANAVLSEVQLRNDDIKNIEKTILELHQLFMDMAMMVEQQGEVLNQTEQHAENTTHDVETGHNHLIKAIKSARATRAKKWCCFVLFLILCVVIAILVWWFGFNHKVNEVFNYRSFEGYILYSHLDSVQQGVGDNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PFM2</accession>
    <name>A0A167PFM2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_164706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295858.1">
        <property type="nucleotide sequence ID" value="XM_018435063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PFM2"/>
    <dbReference type="GeneID" id="28995969"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164706"/>
    <dbReference type="InParanoid" id="A0A167PFM2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="108" mass="12366" checksum="848379197D43C325" modified="2016-07-06" version="1">MYLHSNTSNWSLGKIFLALPVLAKSKKAQETTHTFTIGHLNSLLKWYKFPKFQGSRIFESKKLDISINIRVILNVQPINTLYISSTAKMNTEAYIVSRQVAVQKHKPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PGG9</accession>
    <name>A0A167PGG9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_141731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295906.1">
        <property type="nucleotide sequence ID" value="XM_018430653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PGG9"/>
    <dbReference type="GeneID" id="28991559"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141731"/>
    <dbReference type="InParanoid" id="A0A167PGG9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="57" mass="6612" checksum="48CEF1F422995700" modified="2016-07-06" version="1">MDLSSFINQLQADKRLTENIQKFLGADDNAFKSPGYLLYNYHIQTTDHFLEECSITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PHR8</accession>
    <name>A0A167PHR8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_141799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295979.1">
        <property type="nucleotide sequence ID" value="XM_018430672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PHR8"/>
    <dbReference type="GeneID" id="28991578"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141799"/>
    <dbReference type="InParanoid" id="A0A167PHR8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="55" mass="6438" checksum="E03465E30E93BCF6" modified="2016-07-06" version="1">MSSFVSIMGISMKMDFRFVASRINKPLYDNEENGYHKKVNGVRQRTDQVIQELQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PJJ3</accession>
    <name>A0A167PJJ3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_68420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD78078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296118.1">
        <property type="nucleotide sequence ID" value="XM_018441953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PJJ3"/>
    <dbReference type="STRING" id="763407.A0A167PJJ3"/>
    <dbReference type="GeneID" id="29002859"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_68420"/>
    <dbReference type="InParanoid" id="A0A167PJJ3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="46900" checksum="7EEB2943EDED81B9" modified="2016-07-06" version="1">MSRLFFKSYWFAPFCKRVSIISQAKVSLVNNFDPLDPKNVADPKFANLSLSGLETQALVLQNANCIQALKFLYPHLVLPVAHFFVQSGWISIEEIPACPIAENFGLWNANRLQPRAIKDVLNHCQSLYMLLITKTWLLSPAHLPTSWSQYHLYGSCVAGNYRGSKGVSLLVFPSCPYAVTQIPMPNNYALAVKIGTLQLICLYLPPSMPTHEALDILSAIPLTDDTIICGDFNAHLGSVTGDYTYNPHGVALEQWLEERFLTVLNGVFSPCTPTYISFSPPPMRQTWNLSRLYEDNVRSLYVTTFVTKSAPFSLYCKTLSRIRQPYVHPLMLLLTLSMHSCMTLLVAQLVLTPLAPHIGNRFGPLHCKLQPTIEMIVTSNGVELVALTRSIGGAGTSMHTRSSVSKFRQQSICLGMLFVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PQI5</accession>
    <name>A0A167PQI5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_185187</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296397.1">
        <property type="nucleotide sequence ID" value="XM_018439044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PQI5"/>
    <dbReference type="GeneID" id="28999950"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_185187"/>
    <dbReference type="InParanoid" id="A0A167PQI5"/>
    <dbReference type="OrthoDB" id="5563033at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009598">
        <property type="entry name" value="BCALP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13259">
        <property type="entry name" value="BLADDER CANCER 10 KD PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13259:SF1">
        <property type="entry name" value="BLADDER CANCER-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06726">
        <property type="entry name" value="BC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01396">
        <property type="entry name" value="BC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD78357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="102" mass="11873" checksum="FCAA306C0481BCB0" modified="2016-07-06" version="1">MYCMRYFVPLLLLPFPDAPPVFVVLFLISFFLHQKPCIYCTLLLIALFSSTCYWGQGRCWIDLRNSSLFDVRQDSNATFGQNDGWWDWKITLPVGQTPISNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PRF6</accession>
    <name>A0A167PRF6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_69654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296444.1">
        <property type="nucleotide sequence ID" value="XM_018442140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PRF6"/>
    <dbReference type="GeneID" id="29003046"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_69654"/>
    <dbReference type="InParanoid" id="A0A167PRF6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="264" mass="29101" checksum="DA7562CB2F55BC19" modified="2016-07-06" version="1" fragment="single">LWSRRLLLLPPVGLFCQWVCCFPLVGPFLLPVDLLSLASGPFHIAVGCRLPVASFQLPAACFTSTGGSIYLTGRRHLSHWSDICFLLLPVASAGEPDGSISAAKLSAMSCPQDTSSKADKAHQKPNMGACKKATSAHKRGQNSKCAPDKGQTGPQERPKYVPAKKGEPAHKKGQNMSQQKRANQPTRKAKVCARRKGQTAPQERPKYVPEEKGKPAHKKGQSRRQSKHQSGPQERLMLQMRAREKRLFRDPQGHCQDSKPNQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q6G0</accession>
    <name>A0A167Q6G0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_184669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297196.1">
        <property type="nucleotide sequence ID" value="XM_018438971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q6G0"/>
    <dbReference type="STRING" id="763407.A0A167Q6G0"/>
    <dbReference type="GeneID" id="28999877"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_184669"/>
    <dbReference type="InParanoid" id="A0A167Q6G0"/>
    <dbReference type="OrthoDB" id="2399148at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019166">
        <property type="entry name" value="MIC26/MIC27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033181">
        <property type="entry name" value="Mic26_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268:SF1">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09769">
        <property type="entry name" value="ApoO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD79156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="263" mass="28752" checksum="52DFE4E8174982C1" modified="2016-07-06" version="1">MFSPVLRRSLVTAAATSAVVASSMPSTVYAEEKKLSIYDEPKPKVIIVESPTKLEEHVAYAQKYANNTIEEGKGHVDSLHQKLKNFENDVKATVRETVTDEDVLPNALYVGVAALAGTIIARKHNVVVRFLTSSALAYGAAVYLLPKTTHNIGVQAERLEQRYPELQSVHHSVDQVVHEVRQEVEGVLAQLRGAVDSNASSLASQFQSGLDKVKGETSNVESQVSAKVEQGKKTFSDVKKDVESMYSTRSTPAVEETLKKSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QKE7</accession>
    <name>A0A167QKE7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_162891</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297878.1">
        <property type="nucleotide sequence ID" value="XM_018434704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QKE7"/>
    <dbReference type="STRING" id="763407.A0A167QKE7"/>
    <dbReference type="GeneID" id="28995610"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162891"/>
    <dbReference type="InParanoid" id="A0A167QKE7"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052637">
        <property type="entry name" value="KLHDC3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46461">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46461:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="378"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD79838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="569" mass="63259" checksum="3D3FFCAE1F3EFFC4" modified="2016-07-06" version="1">MNRRPTSPPAQQSPEASVQDEVLLPLPTPAPTPCRILGESLASLVGASLTVVGDSVYVFGGFDRFTDEVFKSLYRLERHAGQSRWTRIIYTKGAAPSELSGHSVTLWNDTKLVVFGGSSEEDNTFFNQIAILDLSTMVWSHPTTTGHIPEGRVNHSATIYQNKLYIAGGNTANPSSFADTLLILDLETLEWQPPVSFVKRQQHATFVYDHRLYLYGGFREDMGRSNHLSFINLDTYAITHLDFESASAPPLTGQRFGQICGDQLVVVVVTAPSTAATVRATRETHQPQIHATGVWTLDLTSMQWQQREMGSRYGVCNWHCFAMGENDTAFYLFGTEEDEPYDYYAMALRVDLQELGIVVVPPPQLGHDLVNLLASHTGDFSISSSLNDEKGEVRVHRLVLMARWPHFAALLQSGMEETVQSTLMMPYGLESLQALVIYLYSDSIDQIRQRGVIADLLVMAQVYELPRLSTLCIRRLHHPMTIDSVSKVYHCAGLAGQPGLQHSALAYMFQHFGAVSHTHAFRSLPREVLFQIWDAMPDNATIVGYTSRSPSVEQDAGRQSDSEMSGVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QT15</accession>
    <name>A0A167QT15_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_163246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298264.1">
        <property type="nucleotide sequence ID" value="XM_018434761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QT15"/>
    <dbReference type="GeneID" id="28995667"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_163246"/>
    <dbReference type="InParanoid" id="A0A167QT15"/>
    <dbReference type="OrthoDB" id="2387796at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="634" mass="74196" checksum="3768F4DE09B9772D" modified="2016-07-06" version="1">MLASELPYDILSLIAQRLSCEDARVCSVVSKSWTLVFREQAFKTLAVFSDTKFKRILNAYACEEYEYLTTNQKDPRYKHQSQNQNQNHTYYPLVQNLEIKHFETNDRQNRTLQHYFQNLRRISVAWNISRVTRTSRETTRWDLWGSLEIIDLRVPRIRESDDLDYVLKTLGALPHLWSFTFECDEIYTAVGWRTIEDLNRHLPGLKHMNICLMLDEIPLQDLLCIEQTVPSTKMTSVGITINQSGPQWFLYLSYKYPNLKHLDWRDSSDYSKMYHDWKTVAPNLMSISSNLSQLQYFNIKTCGTHSNSFHCNFWDVFHYFGLPVKKLVLDAAWDCKLRAEPEDVLAKCMRACSATVESITYSYNYDRHETRMRPVCFNICPRLVTMFLELRESAFTLDSLLDNCPALKDLQLTCKLLLPGESLTSSSRDCLPPAHGLQAITLNRVKTTTKLLNYVSRRCRQLHTMKLIQTNIRGPISQTSGQLDIDMPHTHFKLLKIVSPVFYSYKEEYDYDNMDECATHPVKFLGIEQTDSPDLYTQLDVSCPLVPTKRSLVLFSRELKYMVMKTTSIVLSTDEAQHAFDYFQSFSYRKDSAHNTSVHSLNTYELTEKSFWKVFLFNGYFLLRCKRIDYSVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R193</accession>
    <name>A0A167R193_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynamin-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Scaffold protein Tuba</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_61669</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298658.1">
        <property type="nucleotide sequence ID" value="XM_018440839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R193"/>
    <dbReference type="FunCoup" id="A0A167R193">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167R193"/>
    <dbReference type="GeneID" id="29001745"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61669"/>
    <dbReference type="InParanoid" id="A0A167R193"/>
    <dbReference type="OrthoDB" id="10256089at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031991">
        <property type="term" value="P:regulation of actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF20">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="8">
        <location>
            <begin position="349"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="197"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="311"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="860"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="860"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="879"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD80618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="895" mass="100150" checksum="4B17719B6C6E820F" modified="2016-07-06" version="1">MDPSPIHHGPDAFSKTLDATPRQRSLANSSPTTNSKDGSVNRLSRAFQTNIHPSTNTLQTLVKPGLPPKPPSLRLTNDRPHSSNSSQGGIQVTSNYPPTPTPTTDSTKNEKDEEEQAPLAFKDIRARFQQKQPTVPEIHKKVQLVPTISNVSAPPKVLPKPRLSVTRPTEEVPSPRSSHLPQKGSFTLELAQCLEQPTPRPVVPTSPHSSNPKPRVISRPPDLPLGRNKVLPRRTSNPAIKSNIIHATPISLVARSLTGNSATSTSTTSSTPGSPSRRAWNHGVSIASWFANSTHNEDTSLKDSISIIRETPINSHSTPPPSSGGSFAGSLPISPQLSGKDDGMSKALKRSKVVHELIQTERIYQADMQLLKQTFYDQAQPPLFDKNDVKILFSNLLAILTFESNFVTKLEEACRPENDLPTESNDGGLNTSSNTPTIGAVFNDMMTSIDDIYCDYCKRHEDAVIKLQELETKPEIQAFFAAKRKRKNAFTIILIKYSTNRCREQLEGKTMSWDLGSLLIKPVQRVLKYPLLLKELMILTPQNDPEYEDLAIATKGIQEVADHINEIKRRKDIVEKIVGDKKKTDISVVHGFNKKITRNAQKLKQVAGFSAEPTQDAFFDSLHMKFEHQQEVTRQLARDVQSWVRQVKDHFDHLQIFSASMENLYISWGGVRVRSVECIKRFHSLVSNFSMVMSRDLDVMVRGHVYVVVDDFLKTFENPAQVINKRAQKLLDYDRARDIKSRGDTVDKTLQESADAYVSINAQLVEELPEFFRLTMIYFDILVGNLAMVQTEFNKRLSREWAKLVEGGNIGTSDSILRQYAISMEETLVLLNNISPLNKEQWESVPGAIPGEFESSISLNSRSDSHATGSSIDTPISERSTDLYFDRRTQPKECK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R2G7</accession>
    <name>A0A167R2G7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_178718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298737.1">
        <property type="nucleotide sequence ID" value="XM_018438031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R2G7"/>
    <dbReference type="STRING" id="763407.A0A167R2G7"/>
    <dbReference type="GeneID" id="28998937"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_178718"/>
    <dbReference type="InParanoid" id="A0A167R2G7"/>
    <dbReference type="OrthoDB" id="2152248at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381:SF3">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="1">
        <location>
            <begin position="111"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="286" mass="32259" checksum="B26A95AFAD1BFFEA" modified="2016-07-06" version="1">MSKQEIPVIGLQLTVYGLEEYKALEKPIPVAVMFALHGRVQNMTKMDPICQAICKLNTNPCKKRHIIVVAFDHPNHGSRKIHHLSNYGWSENGYANPNHAMDMWSMLYNSARTVSDLVDVLEHYLFGPQYESRVQVWGVVGFSMGGHASILAAAQDPRLTVCIPIVGTADFLGLMERRLQETDLSAHAHLPKPFCEMVKQRTANLENHLSSTKLLMISGQKDKLVPPSSNDAFISRLSKVHRGKENVDWKCVIVPGVGHEWCPEMIDMSVEWCDKWMVHTLPPNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R4E1</accession>
    <name>A0A167R4E1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_138364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298854.1">
        <property type="nucleotide sequence ID" value="XM_018429980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R4E1"/>
    <dbReference type="STRING" id="763407.A0A167R4E1"/>
    <dbReference type="GeneID" id="28990886"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138364"/>
    <dbReference type="InParanoid" id="A0A167R4E1"/>
    <dbReference type="OrthoDB" id="442243at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF1">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="2">
        <location>
            <begin position="11"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD80814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="337" mass="36709" checksum="D28EECF111F23B1B" modified="2016-07-06" version="1">MSEPEHADRLLLIFVHGFHGSDTSFEDFPNRIRTILTNTHKVDVDAVIYPSYKTMGDISLAVQDLTTWLIDQVNTRQKESKAWGGKGRLMVALLGHSMGGIVSAEVILGLKKRLDDPLDGAFIVGLLAYDTPFYSVNVKYVSSRVISYADQASRFLQGSSSSSSTANARQIGNTAQAAVKATARTASSSSSSSGWGLFAGIVGVAAIGAAAYVGRELISNGINKAFDHLEFVNTLIDTQGCEERVTRLIELDDVLFKCFYVQLPSTGDQPRTFIDLPPDETSHYFVPVSSNASSEVTAHTTMFSSTRNVSYYILGADSISLVSEMIERFRRKHGKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N2E7</accession>
    <name>A0A162N2E7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_95402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441014">
        <property type="protein sequence ID" value="OAD65144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283184.1">
        <property type="nucleotide sequence ID" value="XM_018443902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N2E7"/>
    <dbReference type="STRING" id="763407.A0A162N2E7"/>
    <dbReference type="GeneID" id="29004807"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_95402"/>
    <dbReference type="InParanoid" id="A0A162N2E7"/>
    <dbReference type="OrthoDB" id="18440at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039258">
        <property type="entry name" value="ZNF511"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21354">
        <property type="entry name" value="ZINC FINGER PROTEIN 511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21354:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="110" mass="13242" checksum="66195FEDA71E0463" modified="2016-07-06" version="1" fragment="single">IYCEHHSCHHDGHPLMLPSIYAYELHYEAKHLNTCSVCEKVFPSSHWLQLHLDEFHDVLKKIQKERGEKIYACYVEGCQKRFIDPRLRRLHLIDKHHYPKYFPFDIVLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N3P1</accession>
    <name>A0A162N3P1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_150880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286258.1">
        <property type="nucleotide sequence ID" value="XM_018432565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N3P1"/>
    <dbReference type="GeneID" id="28993471"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150880"/>
    <dbReference type="InParanoid" id="A0A162N3P1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="105" mass="11670" checksum="E5751330CFCB4A80" modified="2016-07-06" version="1" fragment="single">ARFYAEPDPHEGETVANAPECIILSLGWREKVMGIALQGLSSPVVVITLTTACSERFSSRWIKGVFRGYPTTWYLSLVERLGVEPFDRMDTGTLSVLATAQICYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N824</accession>
    <name>A0A162N824_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_146960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD71978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290018.1">
        <property type="nucleotide sequence ID" value="XM_018431768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N824"/>
    <dbReference type="STRING" id="763407.A0A162N824"/>
    <dbReference type="GeneID" id="28992674"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146960"/>
    <dbReference type="InParanoid" id="A0A162N824"/>
    <dbReference type="OrthoDB" id="2404451at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD71978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="833" mass="94697" checksum="7B4F98BD7E8821EA" modified="2016-07-06" version="1">MSSSNANQQRDRISTQQYQCDQCVLFFDNYQKLQNHKRIHRGDSATMTEIDQSILDDVDMYHDENDTSNEDESVSNSEYTMESMELDNTISYKCACNFEDSESEAHIYDSSRISTNTFTKAELMNHDDIMMEPGAKISHGETVDALLKSKSSVKGHEYDVCSSGCRLYGINDDQESCVNCSKPRYKTDPDQSQTPAASMKLMSVGDMLSQMLADPATRELLCYRANRESVAGQLTDIFDGDNYKQLVQQGLFSNPDDIAIGLYTDGPIHQKPTHLDSFLIPIINELRDLEAHGLVVKHNGVELCRSKVYLLLASGDIPAVADMAHIGSHTSLFGCRFCETKGKCPTNRRHGMYFDDISARLRPLEDFKVGSPSKNIYQPSIYTQLSTFSGSSFFALDELHLIARGIGKLVYDLITVTLTKETKFYYTHPDNTLNTTEYPFHIPRADLVTIGNCITSSRKYIPTSFQGSFDNVFAKIDGTRAVDWLDFLLYLVPTLVVPYLPNRAVKTALLSLVKGCALVLQWTLTSELLDEMESYFKHWHSFLYQQVQNNTLSRSVFRPVQHYLVHIPYIIKQQGPLRCYSTHSMERRFAIHNYTSTAISICDEINLIWPKPYGRESYMDLPNDPSGAQLWEPFHQFVNLNDDLVEGVGGPSVKEALLKYYRRTTGLTGHEFGDSVVVVAARLWMDSTVYSSCMYRRKKNETSRGNHYVMFTCPYRNNHNIIVHSWLVGTVQFYFQHVDFYGFPHFLAFAEVMKEHDAASHDSSVPIVKQQSQSTHTLGHQTQPTYAVISVNDICHQVGLVQYPPNGNQFYVIAPYYIFNNNMRITKGNLSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N9L2</accession>
    <name>A0A162N9L2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_159138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290418.1">
        <property type="nucleotide sequence ID" value="XM_018433921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N9L2"/>
    <dbReference type="STRING" id="763407.A0A162N9L2"/>
    <dbReference type="GeneID" id="28994827"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159138"/>
    <dbReference type="InParanoid" id="A0A162N9L2"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22756">
        <property type="entry name" value="OTU_OTUD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF7">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="52"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD72378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="149" mass="17324" checksum="F3CCEEF6C8D211E9" modified="2016-07-06" version="1">MAKGKAKQEKKEIAKTNKAQKNESRKLKRSRNPGLYEDGFGDLNAQLRTLQLCTKDIAGDGNCLFRALSDQYYGSDRKHKEIRQEVCRYMCDHEDDFKYFVEDDRSFKDHVRCMESNGTYGGNMELVAFARLFNVNIKVYQPGLIDYLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N9N1</accession>
    <name>A0A162N9N1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_65557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290438.1">
        <property type="nucleotide sequence ID" value="XM_018441482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N9N1"/>
    <dbReference type="STRING" id="763407.A0A162N9N1"/>
    <dbReference type="GeneID" id="29002388"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65557"/>
    <dbReference type="InParanoid" id="A0A162N9N1"/>
    <dbReference type="OrthoDB" id="2276242at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="27004" checksum="46E2146E5CA681D3" modified="2016-07-06" version="1">MNPINKEICFFNGKKHYPVQQPLPVSPANGYSDMTMAISKMQEYALANNFALVTRDSKPTRVYLKCAKGGHYKNTRNIEDSERKRIPSSGKTGCPYLLKISYKKAAKGYLLLKATNEIEGYHNHPLDDDCLESTLKGRLSKVTVDDAREIMKLVETKTKTREIQKAINEEDNVSHKLYVNDINNIKAAFALKATFLYEKIFYYHFAQKQVVPPKEGEVYAWRQFDECTKFGSNLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NA16</accession>
    <name>A0A162NA16_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_189155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441025">
        <property type="protein sequence ID" value="OAD67234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285274.1">
        <property type="nucleotide sequence ID" value="XM_018439613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NA16"/>
    <dbReference type="STRING" id="763407.A0A162NA16"/>
    <dbReference type="GeneID" id="29000519"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_189155"/>
    <dbReference type="InParanoid" id="A0A162NA16"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46225">
        <property type="entry name" value="C3H4 TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46225:SF19">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="283"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD67234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="337" mass="37777" checksum="562E70F358B8493C" modified="2016-07-06" version="1">MESTSLTTPAPVPAPVPVPVPAITPTPISLTVPVPATATTSTSTTTSISTSISTSTSTSASVSAIVVSVVVLIVGQHETCDKPLDLFLIVFVVRAGVVWPFDVRQRIKSALNTQVENSEHVSKDWADRAKYLLDLFSILWFIVGNYFLFTSDNCSTDAPRLYYTILVWTIFGYLIVLIPTLLCISAIFCLPSVLHVMRLLHLYGIDGLNQGATDTEIQDMITLRYRTSEDGSDTHQAEKSIDKRRRWFSRLGFGQRKQIQDTEVVYDTITFSQQQQQEGEALCAVCLADYEDNDLICKLWCSHHFHKDCVQQWLKLNRKCPMCKQDFQGKNLSQDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NBJ2</accession>
    <name>A0A162NBJ2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zn(2)-C6 fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_65248</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERT1/acuK family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290868.1">
        <property type="nucleotide sequence ID" value="XM_018441424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NBJ2"/>
    <dbReference type="STRING" id="763407.A0A162NBJ2"/>
    <dbReference type="GeneID" id="29002330"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65248"/>
    <dbReference type="InParanoid" id="A0A162NBJ2"/>
    <dbReference type="OrthoDB" id="2538135at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF1">
        <property type="entry name" value="TRANSCRIPTION ACTIVATOR OF GLUCONEOGENESIS ERT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="157"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="221"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD72828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="457" mass="51063" checksum="C72D7A3D44341A9D" modified="2016-07-06" version="1">MSNSVASTTGVQDINFSNFLAYDASDTTSKRKKLAEQNCCFHCQKAQLSCDGSRPCKRCIKRDLANTCTDLLKKKPKYTQDTKESTRGILATLSNYPFPNAVTEALQSIDSHFIDASQLFNFSLADIEFGSETAGLEYGFIGNMLQTPLDGALMGHTTPLPSPTTSSVNHPLTPFQPSPNDEQNRSSTIFDPNPTQLTYFPFATPPTPISFAHSSLLGNPSRMTTASPVNTVNSGQQSPSVSRPLKTKRDSSTSSVTSGRRKGNSGDTPEAVYSSVRRPFNYAEGFHYLIAYVKEKMAREDLMRISRSLAMFRPSFLALIMNLTEEDLVFMEKCIQRTLLEYEKLISFSGTPTIVWRRTGEICLVGKEFSLLTQWSKDILLDKKTYIYELMDNQSAVEYWEKFSTHAFDNTDKACIYSCILKTPTQKPVPCTFCFTIKRDIFDLPSVIVGNFLPILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NBQ7</accession>
    <name>A0A162NBQ7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor CBF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_8208</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290928.1">
        <property type="nucleotide sequence ID" value="XM_018443607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NBQ7"/>
    <dbReference type="FunCoup" id="A0A162NBQ7">
        <property type="interactions" value="506"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NBQ7"/>
    <dbReference type="GeneID" id="29004512"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_8208"/>
    <dbReference type="InParanoid" id="A0A162NBQ7"/>
    <dbReference type="OrthoDB" id="636685at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23645">
        <property type="entry name" value="HFD_Dpb3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF54">
        <property type="entry name" value="CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="3">
        <location>
            <begin position="8"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD72888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="89" mass="10273" checksum="CC44456832AF3AEC" modified="2016-07-06" version="1" fragment="single">RLPGTTIIPLARVKRVIKEDKDVSLINAEAIFCVAYATELFMEYLVTEGYQRAKRDKRKTVYYKDLASTVTEVEQFEFLEDVIPPTLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ND59</accession>
    <name>A0A162ND59_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_117618</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286404.1">
        <property type="nucleotide sequence ID" value="XM_018428586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ND59"/>
    <dbReference type="STRING" id="763407.A0A162ND59"/>
    <dbReference type="GeneID" id="28989492"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_117618"/>
    <dbReference type="InParanoid" id="A0A162ND59"/>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000027">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF22">
        <property type="entry name" value="RAB-GAP TBC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="34"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="270"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="376"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD68364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="433" mass="50243" checksum="88762384E39F01AA" modified="2016-07-06" version="1" fragment="single">NSCILLDFWSKVIADFNSVAKSEPKVLSYHIQRGIPPSVRCMVWELLTKSKDPQLEEQYMQLLGEESVYEQAIARDLLRTFPEHDFFQSSDGQEALFNVVKAYSLYDKEVGYSQGLAHVAGPLLLKMPEEEAFCVLVQLMNRYGLRGNFSPQPELLAQRLFQLDGLLADHLPHVRRHFEVQGVQANMYATQWFLTLFTYKFPLEVIFRLYDVIFSEGIDVVFRFSLALLEKNQSKILSLDFDHLIPFLKNDLLEIYDENASLFIHDAFQIKIATKRLEKLSKEYQVEAARANSEAEAIEAMRRQNKALSETVRQLEIHITDLNKGHKEVATDLISTKMEIARFHDENDALRQQSYDLKKALETMPFEVEQRVKDEMEILATKNAALVERNSSLEDQLVYMENMVIDIKVKYADSENERETLRQRLSELKRLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NE55</accession>
    <name>A0A162NE55_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_63369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286764.1">
        <property type="nucleotide sequence ID" value="XM_018441113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NE55"/>
    <dbReference type="STRING" id="763407.A0A162NE55"/>
    <dbReference type="GeneID" id="29002019"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63369"/>
    <dbReference type="InParanoid" id="A0A162NE55"/>
    <dbReference type="OrthoDB" id="10044727at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="696" mass="80255" checksum="38A29D91E7451214" modified="2016-07-06" version="1">MGRKNARSILTSKMARREGGKFCAKSPIITIHTEKEAGEKEPVEDQPVEEYDWELLDLDTDTMIAAYYNSFLTWRPDAGKNLRGIYRGDSRSSIMRNKRKMKEELEANKDKKVRTLADFGLSVPVAPVSPVTEALTIREAYEKISEMIKPPVSSDSELGKFALFEVSKHIVVKEYFRRLLNNCKNIKASEKAAEIFWTTPSKYRGEAVRGWAKEFLQFGKISEHQQGKHAKRSSIVDDEDLKKKAIVWLRAQKAERRTVVDLKKYLDEMLFPSCLGVKGNVAISTAWKCMRDWGYVHRKNNQDVYYDGHERQDVVQYRHAWATRMMGYKQCMSDFTGEDEEIEVTPLLLENQKKLVMVTHDESTFYAHDGKVDMWLEEGESHIRKKGQGRSLMVSEFQCACHGTMRVKGWVSRRIFNVGAAYDGYWTSEDMLDQLKNHAIPLFESLHEGCTGVFIFDQSSNHKAYATDALVATRMVLKPKVVSENDKFIFKDTTFLRDGRIIPQSFYETVFEAGRKGKGPVEKRQFVGVQRILQERGLWMELNPSNLSRRWRMDCNGEGAKNHCCCARHLLASQPDFSGQKTTIQEVVEEAGHIFELYPKFHCECNWIERYWGAAKRVARLNCDYSFKSLEKNLPSFLDSASPVAGSPSMIRRFYKKTWRYIEAYSKFLDAKDADAEVKKFTSRISKSHRSIGIHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NEY3</accession>
    <name>A0A162NEY3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">M-phase phosphoprotein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_168152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291758.1">
        <property type="nucleotide sequence ID" value="XM_018435810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NEY3"/>
    <dbReference type="FunCoup" id="A0A162NEY3">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NEY3"/>
    <dbReference type="GeneID" id="28996716"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168152"/>
    <dbReference type="InParanoid" id="A0A162NEY3"/>
    <dbReference type="OrthoDB" id="20403at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019324">
        <property type="entry name" value="MPP6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13582">
        <property type="entry name" value="M-PHASE PHOSPHOPROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13582:SF0">
        <property type="entry name" value="M-PHASE PHOSPHOPROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10175">
        <property type="entry name" value="MPP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="19740" checksum="51F1FF6CE7EE76DB" modified="2016-07-06" version="1">MSDNKVKGKQASSRLLGMKFMQRSMEKELQEEHEKERKRVISEAEWTVDYDTGELQKPAIRVEYQPSFLAFSTTTTTGRKSFKGFNKDIEEGEVDIEKTERLKREEAAEEAHSMSDKQMLNSKTTIRSFMRPPKRKDTSKESAESDNVDGEKKKKKKKAKLENQGFIRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NK01</accession>
    <name>A0A162NK01_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_159663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288414.1">
        <property type="nucleotide sequence ID" value="XM_018434031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NK01"/>
    <dbReference type="GeneID" id="28994937"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159663"/>
    <dbReference type="InParanoid" id="A0A162NK01"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="60" mass="7255" checksum="11FD314AB1F3762D" modified="2016-07-06" version="1">MAFEFFNYFRIAQYQDFWPNLRLGSVFPKNPINCFPRSSYLFVQYLFEFAMRSHLCIVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PJC2</accession>
    <name>A0A162PJC2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Formamidopyrimidine-DNA glycosylase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_66028</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291457.1">
        <property type="nucleotide sequence ID" value="XM_018441574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PJC2"/>
    <dbReference type="STRING" id="763407.A0A162PJC2"/>
    <dbReference type="GeneID" id="29002480"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_66028"/>
    <dbReference type="InParanoid" id="A0A162PJC2"/>
    <dbReference type="OrthoDB" id="444592at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000009">
        <property type="entry name" value="Formamidopyrimidine-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="entry name" value="MutM-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="FPG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="H2TH_FPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993:SF9">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="N-terminal domain of MutM-like DNA repair proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formamidopyrimidine-DNA glycosylase catalytic" evidence="10">
        <location>
            <begin position="2"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD73417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="382" mass="43429" checksum="E5645E88ADC2EB82" modified="2016-07-06" version="1">MPEIAEVENARRKCHLNCVGRKIVKVEVQPDPIVFAGKEPADIVKVLENKKVVDTKRWGKYFVLSKYKQYSWYIFSMLNEKQYICTPNGLINIVLDKGPHLVCHFGMTGTLKFKHNVDNLQLHNDKQAKDSTWPPRFYKILLTLKGPQDKSPMDMALTDSRRLGRIRLVGGDPLKSEPISKLGFDPILNLPNEDTFTALVQKRAMPIKALLLDQSFSAQFTYTKTLKFGVGNWVADEILYHSHIHPAQYANTLSTAQCHTLHQNMEYVCRTAVEADADSSLFPDNWIMNYRWKKGKGKGNGVLPNGQVMAFETVGGRTSCFVPEVQVLPESQKTKSEVKTKVKKRPIKEENDQITECIKKDGMSRAERYIKRAKTKANSLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PLI6</accession>
    <name>A0A162PLI6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_145441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292017.1">
        <property type="nucleotide sequence ID" value="XM_018431441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PLI6"/>
    <dbReference type="STRING" id="763407.A0A162PLI6"/>
    <dbReference type="GeneID" id="28992347"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145441"/>
    <dbReference type="InParanoid" id="A0A162PLI6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="280" mass="31477" checksum="39C58033DF492F56" modified="2016-07-06" version="1">MGVVYIAALAALPNLFTRSRALQAKFFRRAETLPSDSLIKALTTQLDLSKEKTTWGELRRSVLWKKAQLLKEHQPRLKDPLKEAYVLLCQKEIDMQLASVNRLVTVARGFANLSERRHLIKWRIAWLPPTPSVECQCGAIKGNQNHMLICPATITLVQKLWSLMNPAPPPEVHLIDYDLNCLPGSFKSPGTWCDWWPCLLALLRAVDQTTSSYKLPEKKAHGQILIDLAAKFCATKPTRPHRIPPPTQELVPGDPLPHFLSKISTIPRQPPPSVPARNCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PU95</accession>
    <name>A0A162PU95_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_59571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294077.1">
        <property type="nucleotide sequence ID" value="XM_018440521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PU95"/>
    <dbReference type="GeneID" id="29001427"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_59571"/>
    <dbReference type="InParanoid" id="A0A162PU95"/>
    <dbReference type="OrthoDB" id="2276822at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="165" mass="18933" checksum="31489C7E0C6AFC0F" modified="2016-07-06" version="1">MLSRVAGFGLRLNLAGSTKTTSQTTSQTTSRKEPTAGQRQSYNNQDQPSKRRLRNVLRNEFLDPLCPSFPPLDHDDHLLVQNFDATRAFHKLQLSLCQHKRKLSLKDYIYCAMAATHILLLSRNQYPEDLSFYFRNHDLKASINGIETKFGIRKLPMSMETTTDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q5V5</accession>
    <name>A0A162Q5V5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_153869</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298416.1">
        <property type="nucleotide sequence ID" value="XM_018433281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q5V5"/>
    <dbReference type="FunCoup" id="A0A162Q5V5">
        <property type="interactions" value="423"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162Q5V5"/>
    <dbReference type="GeneID" id="28994187"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153869"/>
    <dbReference type="InParanoid" id="A0A162Q5V5"/>
    <dbReference type="OrthoDB" id="269919at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD80376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="387" mass="42240" checksum="E5AED4F05125B175" modified="2016-07-06" version="1">MLLPTALEAQVESFISRLKRRQVIGSYEVAKETAVLLRQAVSTTRWKDVNSIIETITELGGRLAMAQPKELAVGNIVRRVLKVIREVAQGELETDGVADVDENESEGYTSEDEDVPVKGKIQSSTSSIVSSLNERPPLITQSSMFRLLADVGPKSDEKKANYNLKPLIIQEINEEIIADLESVYKGIADQAVDYIHANEVIMTIGRSRTVEKFLRRAAEHRKFQVIVAETSPTYQGHQMAIALSAAGIDTTVIVDSAIFAAMPRVNKVVLSAHAVLANGGLVSVTGSHLLAAAAKHHSTPVLVCTALYKLSPLFAYDADAFNVTVAPNSVLDFQQGSLVDKVAVSNPYYDYVSPELVSLFVHNLGSAPPTYVYRLINDNYDPEDTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T1W4</accession>
    <name>A0A162T1W4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NEDD8-conjugating enzyme UBC12</fullName>
            <ecNumber evidence="7">2.3.2.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NEDD8-conjugating enzyme Ubc12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">RUB1-conjugating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin carrier protein 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHYBLDRAFT_160803</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.34" evidence="7"/>
    <dbReference type="EMBL" id="KV441009">
        <property type="protein sequence ID" value="OAD65582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283622.1">
        <property type="nucleotide sequence ID" value="XM_018434259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T1W4"/>
    <dbReference type="FunCoup" id="A0A162T1W4">
        <property type="interactions" value="1084"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162T1W4"/>
    <dbReference type="GeneID" id="28995165"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160803"/>
    <dbReference type="InParanoid" id="A0A162T1W4"/>
    <dbReference type="OrthoDB" id="10249039at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061654">
        <property type="term" value="F:NEDD8 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000005">
        <property type="entry name" value="NEDD8-conjugating enzyme Ubc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="14">
        <location>
            <begin position="23"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="12">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAD65582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="177" mass="20252" checksum="52A4431D1CD0C10C" modified="2016-07-06" version="1">MMKIWSLKAKEAAAEKKKPKISAAQIRVQKDLSELAIPKTIKMEFPDPEDILNFNVIITPDEGFYKDGNFSFTFAINNNYPHEPPKVHCTQKIYHPNLDLQGNVCLNILREDWKPVLSLHSVLVGLQYLFLEPNADDPLNKEAAEDFRANRHVFENNVRKTLQGGWLNGVTYDNVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TB98</accession>
    <name>A0A162TB98_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_189506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441008">
        <property type="protein sequence ID" value="OAD65703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283743.1">
        <property type="nucleotide sequence ID" value="XM_018439671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TB98"/>
    <dbReference type="STRING" id="763407.A0A162TB98"/>
    <dbReference type="GeneID" id="29000577"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_189506"/>
    <dbReference type="InParanoid" id="A0A162TB98"/>
    <dbReference type="OrthoDB" id="10252077at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027819">
        <property type="entry name" value="C9orf72"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31855">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE C9ORF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31855:SF2">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR C9ORF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15019">
        <property type="entry name" value="C9orf72-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51835">
        <property type="entry name" value="DENN_C9ORF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="650" mass="73422" checksum="98A5A191DF0B2966" modified="2016-07-06" version="1">MSPASSDSSPTFNPTLQRSRMTKSKATSSTTAIQPLEITTTAVVMSDAMRKNTDTCPADLLPLPGTEECTKKDEGDRHREGYGWKQPVHHHTHHHSIKSPNTHTGERLKTRSHPIVNLPTSPNISPLNCSRVVTPLTSNTEPVFSVLPPPALKTTSDAMTALQDAAKATKKKKITIPFTNTSNSLAELFESSFFSAVLLVQWSNVVGPKTEKVWSAEEMDERLEKTIGRQILNGEMGRNLNQDEVEAKWVVLHRQAIVCTGFLYNDQIVGSLCGLVLVVPTRYLRNFSQYFGVLQERVPIELVKPLVQLRKAYKRHPGMTWATALDYFTWRRLIPFVRSIMNLESVSLPTECIKISHTILNNESRQMLDSPFIAKVITSHLQTGGSTVLIGNTLTTMNMVINTLALFLSSEERSRSSHARKNHPYMADLYLQEQKQRKWKKEIDLVSETITSKDMEDTNTKLETKVLQSSLPTTLVDMTRLVVKQTPMFPSYNQHQNQYLAYINSKLDEELCIFASGQTRSSAPSADSGWKRHNIFNRTEAIAPLVQTLLDETRKVPTRMREAYIQQWRHLLIRKALALIKWVEEEARCFPLAQSNSGGSSDAPVTKDIVTHLMDALELNNWTDFSIILTQAEKLKKGMVMFLSTYSKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TFM4</accession>
    <name>A0A162TFM4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_152024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441000">
        <property type="protein sequence ID" value="OAD66753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284793.1">
        <property type="nucleotide sequence ID" value="XM_018432816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TFM4"/>
    <dbReference type="STRING" id="763407.A0A162TFM4"/>
    <dbReference type="GeneID" id="28993722"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152024"/>
    <dbReference type="InParanoid" id="A0A162TFM4"/>
    <dbReference type="OrthoDB" id="2277222at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="258" mass="28065" checksum="92128AD0258A3296" modified="2016-07-06" version="1">MFDNVSISVLLDNFSSHSFSPATGVLQCSVLSPHLYSIYINSLPPLLRTVAHSQTTTHVPSPSPTSLDAYNALLAPSGVDGFGHIHFSTPINSLLFADNVAIFCSLSDVQTMLDLAADHSLTLGYRWSPTKCEVIYLKTRASSPVSLLLYGQVLPATDQFIYLGVPFANKGISSKSIATHRRSDTLATMATLNSVGACRSGFSLLLSSRLYKTFVRPKFEYDLAISTLLKQDIKVLESIQDKCLHIIVGGMPRPPQLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TJ34</accession>
    <name>A0A162TJ34_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_116811</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. Interacts (via N-terminus) with TIA1 (via C-terminus); thereby promoting spliceosomal U1 snRNP recruitment to 5' splice sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287032.1">
        <property type="nucleotide sequence ID" value="XM_018428545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TJ34"/>
    <dbReference type="STRING" id="763407.A0A162TJ34"/>
    <dbReference type="GeneID" id="28989451"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_116811"/>
    <dbReference type="InParanoid" id="A0A162TJ34"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000059">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017340">
        <property type="entry name" value="U1_snRNP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148:SF1">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="10">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD68992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="88" mass="10154" checksum="500E4BF152CFB534" modified="2016-07-06" version="1">MPKYYCEYCDIFLTHDSSSVRKAHNAGKNHVLNVRNYYAEIGQDKAQAIIDEITKAYENSASGKNTRKGNQQFRKKGRKRDHNCINCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TKX6</accession>
    <name>A0A162TKX6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_149793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287442.1">
        <property type="nucleotide sequence ID" value="XM_018432339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TKX6"/>
    <dbReference type="GeneID" id="28993245"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149793"/>
    <dbReference type="InParanoid" id="A0A162TKX6"/>
    <dbReference type="OrthoDB" id="2300438at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33324">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33324:SF2">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="316" mass="36585" checksum="A6DFF22046D43A83" modified="2016-07-06" version="1">MSNSNSEISLSTEDNHAIKNEYKTWYKHDGGKDGLTSMERLQQFMLMNCGENLNMYLGGDKEGRTFKSSKVTILNKCNQYFQEQGVYRTTAQIKSRLNNLLTKQYGEAYRVWKNSIKNNSNDEGSTSEKEGLESELNQICPAFFQMEKVMGNRKTGSPAVCDTTKPMEWIHDEDGEQSNGDDDNTDEESAENSHSSNNEEYDSQNDNMSVLCSPPPKSSSSRKRRRVDVEYKELGEEVTRQLNESYVSLEAKIERLYREKLEVLKDDLHIKREREFIHRKFENMMKAVAELAKVQNWSDEKVQEQTDDVYNKTYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TMQ0</accession>
    <name>A0A162TMQ0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_172362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287772.1">
        <property type="nucleotide sequence ID" value="XM_018436781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TMQ0"/>
    <dbReference type="GeneID" id="28997687"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172362"/>
    <dbReference type="InParanoid" id="A0A162TMQ0"/>
    <dbReference type="OrthoDB" id="2216358at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="164" mass="17878" checksum="669F7DD182A47B61" modified="2016-07-06" version="1">MSHCYHMVQGPINKLVYVETDPELFLSHLCSIAAGLVQFDSQGMAMVKVAKLGTSEVQVQSGCQLGTSEDMESINSTSTIKDSSNTSSLPTLSPVLFTITNLPMDKTLPEDQKTGIMNLLNKFCTMFVAKAHTVTIQVVCLSNLYHDESSSRSIVLLERSGKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U1G7</accession>
    <name>A0A162U1G7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_146025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290752.1">
        <property type="nucleotide sequence ID" value="XM_018431584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U1G7"/>
    <dbReference type="GeneID" id="28992490"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146025"/>
    <dbReference type="InParanoid" id="A0A162U1G7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="286" mass="32719" checksum="7A44208AC0AEE52D" modified="2016-07-06" version="1">MAIQRRQLALHPIEITNEQLMEILSTLKTNMTAMGINMAADIIGVFATSSTETITAIDSLSRAPLVSPTNTIANVSQPAFNTLSEFSKKASNDVYAHIRNLMWDPKLKTRNQADILANESKPRWNTNVFFYKSPNKELVMRLLENLKHKFTHEEFREADLRARLHKNFTSRNHIRHLLAYTDNKEAIDLQMKRDCDFTMQMAAMSNGESADEDFKNRTKSIIKIVWPGWRSDEFNTLIKLVDEYVIEAMGSSASQMKERVFTSVSNTAVPDDITPKFPPWALRDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U3X6</accession>
    <name>A0A162U3X6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_168584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291272.1">
        <property type="nucleotide sequence ID" value="XM_018435895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U3X6"/>
    <dbReference type="GeneID" id="28996801"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168584"/>
    <dbReference type="InParanoid" id="A0A162U3X6"/>
    <dbReference type="OrthoDB" id="10667963at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="181" mass="20496" checksum="8687D476763FE9B2" modified="2016-07-06" version="1">MSCRNVTKDTSAVDSIIIKESAPWMKSVSRLEKHFRRCEGEHQVRDLMTKVNSFIENTKQYFDHPEMIFPVTSEVKAPGRLKQVKRKKISPKELCLAQAHKSSWSEKAEVVFERCVPISLFITISKRPVARLRTDIALLPPDGRSPALLMVTVSIPIQINYSSALIVLPTCHSAQGLERKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U6H3</accession>
    <name>A0A162U6H3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_145291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291862.1">
        <property type="nucleotide sequence ID" value="XM_018431407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U6H3"/>
    <dbReference type="GeneID" id="28992313"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145291"/>
    <dbReference type="InParanoid" id="A0A162U6H3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="82" mass="9505" checksum="31136CB65E9A6B7D" modified="2016-07-06" version="1">MAFSASSSRSSHLHFVLLYSPNSFSEERRPPTTTHTVLPSYAGDLVITDKILLQALLKMIQRYKYHITLHEHLLYLEFDKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U8D5</accession>
    <name>A0A162U8D5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyoverdine/dityrosine biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_71450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292322.1">
        <property type="nucleotide sequence ID" value="XM_018442473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U8D5"/>
    <dbReference type="STRING" id="763407.A0A162U8D5"/>
    <dbReference type="GeneID" id="29003379"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71450"/>
    <dbReference type="InParanoid" id="A0A162U8D5"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007817">
        <property type="entry name" value="Isocyanide_synthase_DIT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285:SF5">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05141">
        <property type="entry name" value="DIT1_PvcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="48418" checksum="7DF8B892D37AE673" modified="2016-07-06" version="1">MNSYKENSKDIVYNGSSIGVKNDVSYQGFLGSSFFYSSFKQVLNLFQKKGCSEPNISGELPVLSSSTSTSSNSPVLYLDNIAINDCNTPDRCGHVVQRFLEHFDAELRYHSKPLVDCYSESGKYALASKIHPFVCALEPILMVLPAFPCKSPNNRDKVLGVLPDRTEELGLLRIESFCADVAQYYPQGCQLTIVSDGRVFADLIGVKDELVSVYNNFLEFTLFKSRGGLKHIIFRSLDDHLAAINIDDLEVGQAGENFDIHDKRRAGLMEIFTDADKAEAISNTMVNLGFVRYLEEDLVWPAGMSKTKKKKECRQIARKMMERNVAFSRLCEHHYPTHLRLSIHGYNSSGPKFPIQMSPNLRGPTPWHSVCLEFKDGKTAFVKRKVAAQLVKDGDFELYEHPEFKRPWGFRQLESSYIDFESVVTKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UBD0</accession>
    <name>A0A162UBD0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">26S proteasome regulatory subunit RPN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_124799</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291853.1">
        <property type="nucleotide sequence ID" value="XM_018429010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UBD0"/>
    <dbReference type="FunCoup" id="A0A162UBD0">
        <property type="interactions" value="1061"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UBD0"/>
    <dbReference type="GeneID" id="28989916"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_124799"/>
    <dbReference type="InParanoid" id="A0A162UBD0"/>
    <dbReference type="OrthoDB" id="10252509at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000026">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="7">
        <location>
            <begin position="55"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="8">
        <location>
            <begin position="832"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD73813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="891" mass="99001" checksum="6B7F86D767A48B48" modified="2016-07-06" version="1">MVNTKNGETSKPPAEKQQKNESKPVDETKGNQGKTDKKEQEEELSEEDQQLKSELELLVERLQDKDVKLHRPALEHLRTLIRTSTSSMTSVPKPLKFLSPHYPLLKELHKSWSESGDKKLFADILSVLSMTYAEEGERAALHYRMIGSTEEDIGSWGHEYVRHISGEIMLEYETRTDEEKDTEDLLVLALKVVPFFLHHNAEADAVDLLLGLEAIEKLAQFVDKDTYERVCLYMLGCVNLLASPDDVLFMKTARVIYRKQEKYAQALNLSIRMGDMDLIKEDFNSCPDPLLKKQMAFLLARQQIHIETDDVELSECLNNAHLSHHFIALAQELAVLEPKVPEDIYKSHLENHRTAFSANVDSARNNLASTFVNAFVNAGFGKDKLVMVDEEEQSTSWIFKTKDHGMISSTASLGLISLWDVEMGLSVIDKYMYVEDDNIKAGALLAIGILNSGVREESDPAIALLSEYMDNNSVVVRQSAIFGLGLAYAGSAREDIAELLLPIVSDAALSMELSSMAALALGMVFVGTSNGDITSTILLTMMEREESELKDSWSRFMALGLGLLYLGKQDASEATLEALKTIEHPLGKQAEVLVEALSYAGTGNVLKVQKMLHLCNDHLDKEKEDDTHQTYATLGVALIAMGEDIGSEMSLRTFNHLMHYGESVTRRAVPLALGLLCASNPLVNILDTLSKYSHDNDSEVAISAIFAMGIVGAGTNNARLAQMLRQLASFYHKDATTLFIVRIAQGLLHMAKGTMTLNPFHTDRQIMSPVAMAGLLTTIIAFTDHKTFVLGKSHYLIYSLVTAMYPRFLITFDENLNSLPVTVRVGQAVDVVGQAGRPKTITGFQTHSTPVLLAHSERAELATEEYICLAPVLEGIVLLRKNPEYMEEDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UPP4</accession>
    <name>A0A162UPP4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_102296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294933.1">
        <property type="nucleotide sequence ID" value="XM_018427700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UPP4"/>
    <dbReference type="GeneID" id="28988606"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_102296"/>
    <dbReference type="InParanoid" id="A0A162UPP4"/>
    <dbReference type="OrthoDB" id="3039677at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="177" mass="20298" checksum="EA582553665A0E51" modified="2016-07-06" version="1" fragment="single">NLPRSERFKAENTILVGLMPRPKEPKSEEINHYLKPLVDKMIQLYLGIQIPTYQQTDGATVRAALLMVACDIPAARKTSGFTAHNSTCACYKCNSQFSRLPGTSSVDFRGFDCDQWRHRSDRANRVHAEEWNSASTPSERQQLEVEYSIRWSQLYRLGYFDLVRGTIIDPMHNLFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UPU8</accession>
    <name>A0A162UPU8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_108964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294973.1">
        <property type="nucleotide sequence ID" value="XM_018428083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UPU8"/>
    <dbReference type="FunCoup" id="A0A162UPU8">
        <property type="interactions" value="230"/>
    </dbReference>
    <dbReference type="GeneID" id="28988989"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_108964"/>
    <dbReference type="InParanoid" id="A0A162UPU8"/>
    <dbReference type="OrthoDB" id="2439524at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD76933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="246" mass="28457" checksum="92DBE91B4E3EF1F3" modified="2016-07-06" version="1" fragment="single">SQGWIEKFGKRHCIKMNQIHGETGSTDIKSLQIDKAAIKEKIEAYSACDIYNFDETALFYAAPSRTTISHQKFSGWKENMKQLTVGLLCNANGTDKWSDILMIGHARRPNCFNKNNKKQEAVDHGFSMYHYNSNAWMTRSIFLVFLCCFDRSMKAQNCKVLLILNNFSGHIVDYVPTNVELLFLPPNTTSHFQPFDGGIIRAFKAYFKCKQYAKAYQYIGMIQNDQQDKIWAINKIFEIDQLWAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UR43</accession>
    <name>A0A162UR43_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_131197</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295592.1">
        <property type="nucleotide sequence ID" value="XM_018429410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UR43"/>
    <dbReference type="FunCoup" id="A0A162UR43">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UR43"/>
    <dbReference type="GeneID" id="28990316"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_131197"/>
    <dbReference type="InParanoid" id="A0A162UR43"/>
    <dbReference type="OrthoDB" id="1350766at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000007">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="entry name" value="YbaK/aminoacyl-tRNA synthetase-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="YbaK/ProRS associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="256"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD77552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="726" mass="80779" checksum="F78236798D38BCD5" modified="2016-07-06" version="1">MATCDAVLQSLAKLSLSPRTVSHESVSDNKAWAAALASTKDAVFEMTKTLILKPKTAKTAAATPVVVIALESTETPVPALGKKLSLKDCRFANEELLQTTFGVNKDQVSPFALSNVADLSLVHLVVDSAILALPATTLLAFHPSAADKTVFVTVDQLKAYFKSISKDFVEIDFKAIATAAPAAAAASGSKPAAKPAPKKKAAAEIEASADEVHQMGIEAKKEVDFPKWYQQVLTKSEMLEYYDVSGCYILRPLAYNVWKEITNFFDAAITEMGVEDTYFPMFVSNRVLQREKDHIEGFAPEVAWVTKAGSADLEEPIAIRPTSETVMYPYFSKWIRSYRDLPFRINQWCSVVRWEFKNPQPFLRTREFLWQEGHTAHLTLEGADKEVREILDLYEQVYTDLLAVPVVKGVKSEKERFAGGYYTTTVEGFIPTTGRAIQGGTSHCLGQNFSKMFNIVIEDPSAPANATEEAKKLHVWQNSWGLSTRTIGVMVMIHSDDKGLVLPPRVALIQTVVVPCGLNVKTTKEESDDIYDRCQAVAARLKKTGLKSKADLRENYSPGFKFNHWEIRGVPLRLELGPMDIKKNQVTAVRRDTGAKFAIPLDNLEKGVRDALDTIQNDMFQKAKAKMDSSIVRINKWEDFVRTLNDKKLCLIPWCDRIACEDDIKERSARVATEGEEEDDRAPSMGAKSLCKPFVQPTENPIVPGVTKCIACDHDAKHFMLFGRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UR97</accession>
    <name>A0A162UR97_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_141178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295333.1">
        <property type="nucleotide sequence ID" value="XM_018430541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UR97"/>
    <dbReference type="GeneID" id="28991447"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141178"/>
    <dbReference type="InParanoid" id="A0A162UR97"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD77293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="209" mass="23225" checksum="43596AC490903E8A" modified="2016-07-06" version="1">MDPSPPGRRPDLTAKGKKELVARFPRKSGKESRGEVKQRCTSAYTIPSQQVLSRSTVSTPHRTQPQPTRLDTCAGNCQVARKAEARSSSAARQHTPFQANGCFQNNIFRTTLRITTTNPSGHLRRKLPVKYDNKDRPEKRNVSSPGNETPRESTLVKKSGVENRGEVKQHCTSACTIPSQRMFSRSTVSTPHRTQPQPTRLDTCAGNCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162USN4</accession>
    <name>A0A162USN4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_100880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295673.1">
        <property type="nucleotide sequence ID" value="XM_018427610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162USN4"/>
    <dbReference type="FunCoup" id="A0A162USN4">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162USN4"/>
    <dbReference type="GeneID" id="28988516"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_100880"/>
    <dbReference type="InParanoid" id="A0A162USN4"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD77633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="191" mass="19916" checksum="AB5CDC027D9D528B" modified="2016-07-06" version="1" fragment="single">TIANPGPLGLSAFALTTLVLSLHNAGAGMPASSPSNVVVGLAAFYGGVVQLLAGMWEFRTGNTFGATAFSSYGGFWLSYAAIFIPSFNILGAYSAEGVAATALSHSLGIYLMAWALFTALMLIASHRSSVGLMALFFFLTITFILLSASEFNASEHTKIAGGAFGVITAFVAWYNALSGLLTQDSSYFLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V019</accession>
    <name>A0A162V019_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-4-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.68</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-phosphatidylinositol 4-phosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphosphoinositide kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PIP5K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_87373</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14425"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.68"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.1.68" evidence="2"/>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297142.1">
        <property type="nucleotide sequence ID" value="XM_018443662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V019"/>
    <dbReference type="FunCoup" id="A0A162V019">
        <property type="interactions" value="423"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162V019"/>
    <dbReference type="GeneID" id="29004567"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_87373"/>
    <dbReference type="InParanoid" id="A0A162V019"/>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17303">
        <property type="entry name" value="PIPKc_PIP5K_yeast_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase its3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="12">
        <location>
            <begin position="27"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD79102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="423" mass="49130" checksum="0A1B7004ECF3599F" modified="2016-07-06" version="1" fragment="single">RRLSRLKKPKDGEDEDRVMMGTRIAEGHQNYVLMYNMLTGIRIGVGRVSAKMDKPVEDADFTAAHKLAFDVTGDELTPGAKYDFKFKDYAPWVFRHLREKFGIDPADYLISLTSKYILSELGSPGKSGSFFYYSRDYRFIIKTIHHTEHKFMRDILKQYYEHVVDNPDTLLCRYYGLHRVKLPHGRKIHFVVMANVFPPNKDVHETYDLKGSTIGRFLPEEEIEKNPHAVMKDLNWEKRGRKLQLGPKKRKIFISQLVRDVKLLIQLNIMDYSLLIGIHDLVRGNQDGIRNSTLQFFQPDTKKAERRATLMKRRESKAQVHRKAIAQANPDRLDISELPEDPFGERSKCVFYADEGGFQSTDELNRPTSSLYFMGVIDILTPYDMKKKSEHFFKSMTQDKKAISAVKPAHYGDRFMGFMAKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162VA57</accession>
    <name>A0A162VA57_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_138705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299202.1">
        <property type="nucleotide sequence ID" value="XM_018430050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162VA57"/>
    <dbReference type="STRING" id="763407.A0A162VA57"/>
    <dbReference type="GeneID" id="28990956"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138705"/>
    <dbReference type="InParanoid" id="A0A162VA57"/>
    <dbReference type="OrthoDB" id="3039677at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="165" mass="18583" checksum="4C5056FF85184145" modified="2016-07-06" version="1">MNNLPREERMKPENIILVGVMSGPKEAKIDQMNNFLEPLVDELVELYGSITMKTPEFPNGTSIRTALMCVACNIPAARKTAGFTGFASTNACHICKRHFTVVAGTSKINYSGFNHENWVSQTKEENATKAEMWFCAESDAERAVLEKQHGTRFSELHRLHYFDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WBJ5</accession>
    <name>A0A162WBJ5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">UDP-N-acetylglucosamine transferase subunit ALG14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Asparagine-linked glycosylation protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ALG14</name>
        <name evidence="13" type="ORF">PHYBLDRAFT_128732</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterodimer with ALG13 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALG14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441006">
        <property type="protein sequence ID" value="OAD66075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284115.1">
        <property type="nucleotide sequence ID" value="XM_018429236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WBJ5"/>
    <dbReference type="FunCoup" id="A0A162WBJ5">
        <property type="interactions" value="158"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162WBJ5"/>
    <dbReference type="GeneID" id="28990142"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_128732"/>
    <dbReference type="InParanoid" id="A0A162WBJ5"/>
    <dbReference type="OrthoDB" id="17098at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041549">
        <property type="entry name" value="PssD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154:SF4">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007840737" description="UDP-N-acetylglucosamine transferase subunit ALG14" evidence="12">
        <location>
            <begin position="17"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD66075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="204" mass="23295" checksum="519EA5F032D6A96D" modified="2016-07-06" version="1">MFIFCICVFLIRVCWVLYSKLPILPRTKSCKTMIILGSGGHTGEMVQLIKGLNPIRYNPRIYVVSEEDQLSCTKAKEHEMNIKSEFPCDIRTIPRARRVGQSWSTVPWSVFRTLLASLKMILLSPPDVIICNGPGSCVPVCMVAYIPRILGIKPIRIVYVESLARVKTLSLTGKILYFFADRFIVQWPNLIQRYPRAEYKGILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WSV6</accession>
    <name>A0A162WSV6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHYBLDRAFT_64185</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288775.1">
        <property type="nucleotide sequence ID" value="XM_018441250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WSV6"/>
    <dbReference type="STRING" id="763407.A0A162WSV6"/>
    <dbReference type="GeneID" id="29002156"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64185"/>
    <dbReference type="InParanoid" id="A0A162WSV6"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049898">
        <property type="entry name" value="MARR_BRCT_CHROMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032450">
        <property type="entry name" value="SMARCC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802:SF41">
        <property type="entry name" value="BRAHMA ASSOCIATED PROTEIN 155 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802">
        <property type="entry name" value="SWI/SNF COMPLEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
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        <property type="entry name" value="SWIRM-assoc_1"/>
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        <property type="entry name" value="SWIRM-assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52032">
        <property type="entry name" value="MARR_BRCT_CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Chromo" evidence="14">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="SWIRM" evidence="12">
        <location>
            <begin position="541"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="11">
        <location>
            <begin position="701"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="13">
        <location>
            <begin position="758"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="763"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="289"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="469"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="863"/>
            <end position="907"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1030"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="870"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1033"/>
            <end position="1154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50934"/>
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    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAD70735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1154" mass="131477" checksum="B6E5578EFA002A96" modified="2016-07-06" version="1">MAAKNPKSAALDQSFYELPETVACFESIQGPLLAELQAQQRDLTFDARDLSILTGQLQQFQQEYLGAYNRPNNAPLRIPTKLFRIDHGKSISKRSALYKILLAAYEYRITKGWRKWDFGNPNKKSKHVDLFQSIRTYLLDMAIITAPRIAFSDTTPESARKTLTGMAWKMGVHVADNINSATHILYGPLHEYNEIEEEWLRTLEKKNGKVLVHWWYYPDSYDSWLIQTDQFADPEEAPNHSGPWHISCRWLQDSSKFNELMNEEDYEEIDADEGSEPENEDVDMIQANDEEEDEEIEEEREMKHHQPQIKQEHIQEHYQSPQNQQQQQEQLDEQEEQLDQQEQQEQQEQQEQLEQLEQQEQQDHQEQQEQQDQQDQQDQQEHQERKASPILQNQSYIRNQDDDQHRHKRKISEAHSDIVSVTSEPASASAKENMSTNTHMHPFDMVPPTVIPAPVIDVNYQPSVRIRDIERERPQLGSRQRKNEFEPYSNGDITNISQHTEAFIEYPRRPAKMLKLDESYQKKPGEVIDISSLASVMPIDYTTINAPSWFDIKTVHQIEKMALPEFFDPQGKKSEQLAKDYMHYRDFMINTYRANPDFYLTAVACKDKLDADIVSLVRIHSFLELYGLINAQVDPRRRIFDPYVDSEPEAGVKPKSQRDYRNVNNVDMQYLRDLIFDPSITADKKSAWDLSIEDDTNPDIRKIYVCSTCQTDCSLVRYQCLKHKQVYLCIDCFLEGRFTSTLSSGDFLRVESSNDRYGTDEEWSNSEILRLLEGVDKYDDDWLMISEHVGIRSKEQCITQFLQLPISDTFLTAQLADKELEELPFGDQPNPVMTMIAFISGHINPGVGAAAAKAALKELLQSEEAKNEMDIDNNDDEYDDEEDEDEEDEENDEEDNERVIKEENEDIDIDIDNSRHQVKSEKEDTMSEQEKLLFKGLFSPETMKKATMAGLLSAVEQAKKLASYEDQEIQHWTRLAVKTLVDKISLKVQQYDELETSLDNERKELEKQGLVLTSSIENLHRQYAATTAITSGTTPDIPTAITPTASATATSTSTTPAATASAAATTSTATSTTPDAATSTANTSAAESTTTTITSTASTPTMSTASAIPTNITTAASNSTSNSNSTADTTSTTPTTPTTTTTTTTSHTADNTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WT06</accession>
    <name>A0A162WT06_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cas1p 10 TM acyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_96884</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PC-esterase family. CASD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288815.1">
        <property type="nucleotide sequence ID" value="XM_018443986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WT06"/>
    <dbReference type="GeneID" id="29004891"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_96884"/>
    <dbReference type="InParanoid" id="A0A162WT06"/>
    <dbReference type="OrthoDB" id="1932925at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012419">
        <property type="entry name" value="Cas1_AcylTrans_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533:SF1">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07779">
        <property type="entry name" value="Cas1_AcylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="576"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="641"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Cas1p 10 TM acyl transferase" evidence="9">
        <location>
            <begin position="226"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD70775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="672" mass="78557" checksum="FB2C9D675E268691" modified="2016-07-06" version="1" fragment="single">MSHEYTPKEISTCLNHSRVLYIGDSIMREQYYSMAKLSRDFKITGSLHIDRHMVFEELGMVYDFWWDPYLNSTRTIELLEGKSKEQKPSLLVMGSGTWHMRRLKKNYFKVWKPTMERVFKAVEKHRIADTVLLSPVETPKYDLLWPPRFKTITAPKISQMNAYLKKREAELKTKVPFKITYVWNEIASTSNNATIDGLHFLQPVTKAQGLLALNFRCNQELPKTFPMDTTCCYTYPSPQWFQTVWFLVPLVWVPFCFLVANYEKRQDQFFVKYLVPSNNVLYALLTMGLGVGYMYLGDRTQLFGKIHKVFQPVVFSGLLLLLLGVGLVTLRKKESGDQGFLNRAQTDEWKGWMQIIILVYHFLGASSVSGIYNPVRVLVAAYLFQTGYGHFFFFYKKGDYSFGRVLSIMVRLNLLTFVLQYLMNTNYLSYYFSPLVSFWFIIIWVTMYVGNKWNKTPSFLLAKMFGMAMLTTLIIHYPGLLEFAFKCLEYTFNIQWNPVEWRFRLALDAWIVYVGMLIAYLNIKITEQKLPSKAYWSTAKNASIVVSCVAMIWYFWFELSRPNKFVYNTYHPYISWIPVLAFTILRNCTLGLRNRSSRFFEFIGKCSLETFIGQFHMWLAADTQGLLLILANPMWAHGLGWWVNLGLSTVLFVFVSYHLSQATGEITQWICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162X302</accession>
    <name>A0A162X302_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_169414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290315.1">
        <property type="nucleotide sequence ID" value="XM_018436070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162X302"/>
    <dbReference type="GeneID" id="28996976"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169414"/>
    <dbReference type="InParanoid" id="A0A162X302"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="270" mass="30710" checksum="E9ED961F90BC4AEC" modified="2016-07-06" version="1">MKGFSVPSVRAEHHYLNECIDAMDRKLVVIQKPFLFGNSWLDRCSSASMALVAVYDYKKGNQKQYIYLQDYMCIIFGNSKKYLEELLRADETNPQRMRMRILRAYTETAFEGRAKHYEANNLHFASLSSLAIISLLRRSLLEICFLARTSSLALLSLDALFKRRASKNDTTKASFTYSNYELGEIKASSKISVSLSELLKNSDWNSSCVNLVFLVSDVNDDESDNDGAGIDTDADVEGRRNENWARKLGVGICDSIFLPDEYYWGCICLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XBK8</accession>
    <name>A0A162XBK8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="4 15">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHYBLDRAFT_112544</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids. SPC associates with the translocon complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase S26B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 15"/>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291775.1">
        <property type="nucleotide sequence ID" value="XM_018428295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XBK8"/>
    <dbReference type="FunCoup" id="A0A162XBK8">
        <property type="interactions" value="347"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162XBK8"/>
    <dbReference type="GeneID" id="28989201"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_112544"/>
    <dbReference type="InParanoid" id="A0A162XBK8"/>
    <dbReference type="OrthoDB" id="10257561at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAD73735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="175" mass="19950" checksum="4ADBF6A49F33CBFD" modified="2016-07-06" version="1">MFAELRRMNVRQVAFQVLNIITIVASALMIWKGLSVLTNTESPIVVVLSESMEPAFTRGDLLLLAMPKDDLVNVNDICVFKLPGREIPIVHRVIKLHDDATTSQQYLLTKGDNNSGDDRGLYDRRQMWIHREHVVGKVKGFVPYVGMVTIIMNDYPWMKFALLSVLALFVLVHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XIK0</accession>
    <name>A0A162XIK0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_158600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293155.1">
        <property type="nucleotide sequence ID" value="XM_018433817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XIK0"/>
    <dbReference type="GeneID" id="28994723"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_158600"/>
    <dbReference type="InParanoid" id="A0A162XIK0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="140" mass="15285" checksum="85EE30B4C87F19D4" modified="2016-07-06" version="1">MALSAAGYPVPTANHPSIDPLVFGEGRPGMPLMVPIPFNAGAGQSSARQAPPPPPPPPQPPMEPFMPHMMHLPIPGPHHLHHHPLPPHLQSQVPHRYPLQRDMLPPGNDPFRINLPNGMHGMTNAGLPPMYAKNQGWERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XVD9</accession>
    <name>A0A162XVD9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_109313</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the YIF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294725.1">
        <property type="nucleotide sequence ID" value="XM_018428102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XVD9"/>
    <dbReference type="FunCoup" id="A0A162XVD9">
        <property type="interactions" value="361"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162XVD9"/>
    <dbReference type="GeneID" id="28989008"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_109313"/>
    <dbReference type="InParanoid" id="A0A162XVD9"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005578">
        <property type="entry name" value="Yif1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083:SF0">
        <property type="entry name" value="YIP1D-INTERACTING FACTOR 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
        <property type="entry name" value="YIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD76685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="235" mass="27017" checksum="DE00EA808316D353" modified="2016-07-06" version="1">MQFAGNAVAQGTAYMERNFNQWVNMPALRHYFNVNNMYVITKLKLLLFPWRHSPWSRSIRRTETGQMDGFRPPREDINSPDLYIPVMALVTYILLCGLAAGRQGSFHPEKLYVAASTATAVAFTELVFTRLGCYFLSIPFEASLLDLIAYYGYKYVCIIVVDVVDLLGAKGWVSWVVFLYTGFSIGFFLLRSMRYVILPDSAAGPSTLNPQRKRRMWFLLMIAAFQMLYMFFLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y9N7</accession>
    <name>A0A162Y9N7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin reductase</fullName>
            <ecNumber evidence="8">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NDI</name>
        <name evidence="12" type="ORF">PHYBLDRAFT_105970</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="8"/>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297235.1">
        <property type="nucleotide sequence ID" value="XM_018427929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y9N7"/>
    <dbReference type="FunCoup" id="A0A162Y9N7">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162Y9N7"/>
    <dbReference type="GeneID" id="28988835"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_105970"/>
    <dbReference type="InParanoid" id="A0A162Y9N7"/>
    <dbReference type="OrthoDB" id="371245at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000064">
        <property type="entry name" value="Thioredoxin reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="11">
        <location>
            <begin position="7"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD79195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="351" mass="37286" checksum="5C3E4D98F34ABBE8" modified="2016-07-06" version="1">MAPQHHKVTIIGSGPAGHTAAIYLARANLAPTMFEGMMANGFAPGGQLTTTTDVENFPGFPNGVMGGELMDKMREQSVRCGTVIETETITKLDCSSRPFKIWREGTETNSASEPSDTSDAVVIATGASAKRMNLPGEDKYWQSGISACAVCDGAVPIFRNKPLVVIGGGDSAAEEAIYLTKYGSQVHVLVRRDKLRASKVMAARLLKHPKVIVHFNTSPTGALGDGSLLTAVTTKNTLTGEEGQIEANGLFYAIGHVPATELIKGQVDLDNDGYIKVIPGSSETNIPGLFAAGDVQDKRYRQAVTSAGSGCMAALDAERFLSELEESQSETNTGSQSQLDLDMKFKPKSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YI57</accession>
    <name>A0A162YI57_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_105401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298895.1">
        <property type="nucleotide sequence ID" value="XM_018427901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YI57"/>
    <dbReference type="STRING" id="763407.A0A162YI57"/>
    <dbReference type="GeneID" id="28988807"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_105401"/>
    <dbReference type="InParanoid" id="A0A162YI57"/>
    <dbReference type="OrthoDB" id="2288804at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11651" checksum="D1B437EA1CB239D8" modified="2016-07-06" version="1" fragment="single">DKAAIKEKIEAYSACDIYNFDETALFYAAPPRTTISCQKFSGWKENKKRLTVDLLCNANGTDKWSDILMIGHARRPNCFNKSNKKQEAVDHGLSMYHYNSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YJW3</accession>
    <name>A0A162YJW3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_73689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299245.1">
        <property type="nucleotide sequence ID" value="XM_018442901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YJW3"/>
    <dbReference type="STRING" id="763407.A0A162YJW3"/>
    <dbReference type="GeneID" id="29003807"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73689"/>
    <dbReference type="InParanoid" id="A0A162YJW3"/>
    <dbReference type="OrthoDB" id="2439011at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="29120" checksum="C2E154F1EEBF3829" modified="2016-07-06" version="1">MPGPKEASTDEINNYLRPLVDELMLLYKGITIDTYNCSGALVRAALLMVACDIPAARKTCGFTSHNSTCACYKCNRQFAHVDGTTAVNYFGLKFSEWVGRTKEENRRHANLWKNAKTLTERKRLEIENGVRWSELHRLVYFEPVRATIIDPMHNLFLGTAKRMMDIWIANNLLDDKDFVEMQEEANRMVLPVGYTTLKIKIGKKFPFMKADEWKSWCLIYSPVLLKTRLRDDLLGNWIHFVDAFFIQNKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZBD4</accession>
    <name>A0A162ZBD4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_160812</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441009">
        <property type="protein sequence ID" value="OAD65611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283651.1">
        <property type="nucleotide sequence ID" value="XM_018434261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZBD4"/>
    <dbReference type="FunCoup" id="A0A162ZBD4">
        <property type="interactions" value="650"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162ZBD4"/>
    <dbReference type="GeneID" id="28995167"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160812"/>
    <dbReference type="InParanoid" id="A0A162ZBD4"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000016">
        <property type="entry name" value="Proteasome subunit alpha type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="244"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD65611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="276" mass="30325" checksum="144B14D80AD18FE4" modified="2016-07-06" version="1">MFRNQYDNDVSTWSPQGRIHQVEYAVEAVKQGSAAIGLKNKKYAILLALKRSSGELASYQKKLIKIDDHMGIGIAGLTSDARVLSNFMRTEAMRSKMLYDRPLPVQRIVAAIADKAQVNTQQYGRRPYGVGLLVIGHDETGPHLFECSPSGTCFEYHAMSIGARSQSAKTYLESHYQEFANESLNELVRHGLQALRDTLQQDSELNIHNTSLGIVGEDRDFEIIEGEALQVYLDLLGEETGRTRRSAAGVSASDSVAAEGQRTGEASGVTPMDTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZF97</accession>
    <name>A0A162ZF97_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_175221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441003">
        <property type="protein sequence ID" value="OAD66411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284451.1">
        <property type="nucleotide sequence ID" value="XM_018437449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZF97"/>
    <dbReference type="GeneID" id="28998355"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175221"/>
    <dbReference type="InParanoid" id="A0A162ZF97"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="109" mass="12690" checksum="E4AFDA3837308785" modified="2016-07-06" version="1">MGQIMFMTRRVRMRINYQNMKIGEMEKVVLTSKTERDTISVSLYTVSEQNRTVIRVKQLFLFYDSTYEDNTGNTAVEHVPRYVCPCVCDILLSKRRHGFHGHATLTLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZGI3</accession>
    <name>A0A162ZGI3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_152370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441002">
        <property type="protein sequence ID" value="OAD66571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284611.1">
        <property type="nucleotide sequence ID" value="XM_018432894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZGI3"/>
    <dbReference type="STRING" id="763407.A0A162ZGI3"/>
    <dbReference type="GeneID" id="28993800"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152370"/>
    <dbReference type="InParanoid" id="A0A162ZGI3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26406" checksum="A360E91E1994251E" modified="2016-07-06" version="1">MTEHSQHNPLSRAYSTDSCPPGSLCTRHVGHSVSHLCFQGIACPLIPLFLYEKEATLVGVSSDLLGKFLPHYLPSDIGEWIRVSRTCHDWTALTDLLTSTYGLNLEIEKAQCCQALQSTKQGTLLIRIFQVKFATLANDIPASCRLSERTVLAIFMDNIKPQLRQLMEPTLTKYDSWESAYATAVKHEDRCGEYAPPPAFTPLSSHAPQPMDCLAAIYSSRPHHNGPLDGVPRLWGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZIA7</accession>
    <name>A0A162ZIA7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_151920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD66981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285021.1">
        <property type="nucleotide sequence ID" value="XM_018432785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZIA7"/>
    <dbReference type="GeneID" id="28993691"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151920"/>
    <dbReference type="InParanoid" id="A0A162ZIA7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="124" mass="13834" checksum="EC9F4A3444791E50" modified="2016-07-06" version="1">MTQLASMYCKVGQLMDGQKRNIGAAAWQESMPASLPALFSLSPSPVPAMSEQEMSSVILILAHHTHTYLTNWRLIDNEMGLEVELLSEMSFLHLLQKDVMLDGESDVKDMNIATVHVLRVKHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163A603</accession>
    <name>A0A163A603_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_159394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289341.1">
        <property type="nucleotide sequence ID" value="XM_018433980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163A603"/>
    <dbReference type="GeneID" id="28994886"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159394"/>
    <dbReference type="InParanoid" id="A0A163A603"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="209" mass="23734" checksum="9DE911145B9688F4" modified="2016-07-06" version="1">MDSVIIIHFGSMEHLFPQFRDPKWLNQLVGLIGKSLEQLKLPAIWWMTSNSPLHKACLENPSFATYNTAHICLEDIPHDFIIPAIRYGFPKKCFDTWWIDVHKNKVEAPRKRNIGALHHGGAGTFGSMATYGVPQLILPCMFDQFFWAETGESHGISKTLNVDDHDWSKAFSWSVKDKKSCQGYQTIVKSSTEEGLLRTLNAILSNKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AAQ6</accession>
    <name>A0A163AAQ6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carbohydrate-binding module family 13 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_80022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290241.1">
        <property type="nucleotide sequence ID" value="XM_018443539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AAQ6"/>
    <dbReference type="STRING" id="763407.A0A163AAQ6"/>
    <dbReference type="GeneID" id="29004444"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_80022"/>
    <dbReference type="InParanoid" id="A0A163AAQ6"/>
    <dbReference type="OrthoDB" id="9895617at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23454">
        <property type="entry name" value="beta-trefoil_Ricin_GllA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022234">
        <property type="entry name" value="DUF3759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450:SF1">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12585">
        <property type="entry name" value="DUF3759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="311" mass="35594" checksum="7C107E6C1A9B36A6" modified="2016-07-06" version="1">MTAGESAFPIGYFFIISKLNNLVIDVENPTEAGPGARIIMKERQAKSPERDSQLWIHQNGFLTNKMTGLVLDINRSPSFMAIFNGENHLYLDQMKEEDTAHDQRFAFEEETGFIYSLHNENIVFDIRKAEVAEGGRVIVYKRKGISEDSSKKPLHQYWSVELGDPPKIDEDDEEEDESKRARLRSWFGNWSGWDKRKNGMLVEHDLEEAHEKVYTEKKASLSHELLAGAAAFAAVHAWEKRQEEAGEEVHHSMTKKLLASLAAAEMVKLYEERGIEEEDDDEEKKIEKKNILQRMSASAAQNLFEAKHGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ABZ5</accession>
    <name>A0A163ABZ5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="14">CPR</shortName>
            <shortName evidence="14">P450R</shortName>
            <ecNumber evidence="14">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHYBLDRAFT_134296</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="14">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="14">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Single-pass membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Mitochondrion outer membrane</location>
            <topology evidence="14">Single-pass membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Single-pass membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="14"/>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290501.1">
        <property type="nucleotide sequence ID" value="XM_018429639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ABZ5"/>
    <dbReference type="FunCoup" id="A0A163ABZ5">
        <property type="interactions" value="620"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163ABZ5"/>
    <dbReference type="GeneID" id="28990545"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_134296"/>
    <dbReference type="InParanoid" id="A0A163ABZ5"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000024">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000001">
        <property type="entry name" value="NADPH--cytochrome P450 reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03212">
        <property type="entry name" value="NCPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0274">FAD</keyword>
    <keyword evidence="1 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 14" id="KW-0288">FMN</keyword>
    <keyword evidence="14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6 14" id="KW-0521">NADP</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13 14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10 14" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="16">
        <location>
            <begin position="65"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="17">
        <location>
            <begin position="280"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="71"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="480"/>
            <end position="483"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="498"/>
            <end position="500"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="517"/>
            <end position="520"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="587"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="649"/>
            <end position="650"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="655"/>
            <end position="659"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="691"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="729"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAD72461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="729" mass="81961" checksum="298CE13AF48D695E" modified="2016-07-06" version="1">MESLDIILLGTIGLGTIAWFARHQIANTFKSSKDTVIDDSESSEKPTPKAERNFVKIMKEQGRQVIIFYGSQTGTAEDYAARLAKESSQKYNVSCMTADLELYDLSYLDTLPKECLAIFVLATYGEGEPTDNAVEFWDMLNDESVEFSQSESQSESDSGSPLSNLRFIVFGLGNKTYEHYNSVCRTVDKRLEQLGGTRVCERGEGDDDSSLEDDFLAWQETLWPAFCEAMGVDENPTSSGPRQPTYKVDELDSFENDLVYMGEISERPKDSTSAIVYDAKRPFAATVTSRELFFVKDRHCLHMEIDLGDSNLSYQTGDHIAIWPTNNEVQVKRLASILGLQDKLDRVVNVSSVDAAASKQHPFPVPTTYRTIFRHYLDICAIPSRQTLMSLVDFAPNDASRAFLQTLATDKEAYKSQVSEPVRNLGEVLELVARAGKLDQDQDQDRKTNTEANGNHSTKGAFEAVPFDLVVESISRLQPRYYSISSSSKESPRSISVTVVMLDYKPQKSNNERTVYGVATNYLWSIHAAVHELEKPVGYPDYVVAGPRGSYMNDDKSVVKVPVHVRRSQFKLPRNPTVPVIMVGPGTGVAPFRAFVRERAAQKLDKKPVGPTVLFFGCRHSQQDYLYADEWPGLFETLGEDSRIITAFSREHAEKVYVQHRLEQEGEEMWGLLERGAYVYVCGDAKSMAKDVQHTFTVIAQQYGNKTEEKAAEFIKSLRSTGRYQEDVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AFA2</accession>
    <name>A0A163AFA2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_71578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD73091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291131.1">
        <property type="nucleotide sequence ID" value="XM_018442506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AFA2"/>
    <dbReference type="STRING" id="763407.A0A163AFA2"/>
    <dbReference type="GeneID" id="29003412"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71578"/>
    <dbReference type="InParanoid" id="A0A163AFA2"/>
    <dbReference type="OrthoDB" id="2288122at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="353" mass="41783" checksum="FC3E6EEE0191E0CC" modified="2016-07-06" version="1">MPIGFTINLIVMRRTWSSLGSLLKILSNEKTSQPAQKRVRTTKSIKIGCPASIYKHIITDGTVCIKYNWQYPNHNPFKIEEISLSRLPDELKQWVEGLVSQNMDWKSIKNMLRMSEDRLLELEQAGDRSSFPSSLLIDYQYVRNVINARMMKLSRKHVDHYKSVKLWVQELNESENTTLFTVHKNGLFLVLWVSEWQKEFLENLEEWCIDSTHKTSKAWEVNVKKHIKVQNSTHALNIACNSVYAVLSNMMHATTSVAYNTLYNEFLVKFGEYENFILFFNRMWVRKKELWCKTWRLAATFHTNNLIESYYNQLKTFYLGRARFLQADKLIYLLAKVLTLDYRQENVKTLYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AHM9</accession>
    <name>A0A163AHM9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MoaB/Mog domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_4977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291591.1">
        <property type="nucleotide sequence ID" value="XM_018440191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AHM9"/>
    <dbReference type="STRING" id="763407.A0A163AHM9"/>
    <dbReference type="GeneID" id="29001097"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_4977"/>
    <dbReference type="InParanoid" id="A0A163AHM9"/>
    <dbReference type="OrthoDB" id="448496at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047884">
        <property type="term" value="F:FAD diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042726">
        <property type="term" value="P:flavin-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056596">
        <property type="entry name" value="FLAD1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675:SF1">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24102">
        <property type="entry name" value="FLAD1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="1">
        <location>
            <begin position="3"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="228" mass="25154" checksum="F87A5E6B0931B93E" modified="2016-07-06" version="1" fragment="single">TAACCLIGDEILSGKTRDLNSYCLANFLFDLGISLKRIDVVADDDEAIGESVRRLAKDHTLVFTSGGIGPTHDDITYAAVAKAFDLSLEIDNETKQRLTDVATKRQKALTDAHLRMALFPYPAVLVREDPSLLIPVVVVVGQIYILPGIPQLFQRLLYSLKPYFARLIISQGQSLKGFVRREIITYQPETQLAAYLTGLQAEYPKDQLLIGSYPELNGKVVVSVVGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ANX0</accession>
    <name>A0A163ANX0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_76569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292811.1">
        <property type="nucleotide sequence ID" value="XM_018443172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ANX0"/>
    <dbReference type="GeneID" id="29004078"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_76569"/>
    <dbReference type="InParanoid" id="A0A163ANX0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="190" mass="21528" checksum="FCBAEB0EA05B0C3F" modified="2016-07-06" version="1">MYESKGAVVLGKEKSVLAANLGLVPNVPCDWFSMRASWDNAIHLIDDIGLNMETFTTNTNSLTLHDVSNKSEIPNEQELSQQKLIVNDGFHQLVESFRKMENSQNIDRTHNYLLEDERKILEVLRVTLEKAESFCASSQYSLLSLVHNILLGGIPNEETMLSLSSNLLDGLIKDFGWELFDYIHPFLISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AP18</accession>
    <name>A0A163AP18_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_144159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292841.1">
        <property type="nucleotide sequence ID" value="XM_018431149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AP18"/>
    <dbReference type="GeneID" id="28992055"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144159"/>
    <dbReference type="InParanoid" id="A0A163AP18"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="81" mass="9168" checksum="8ACC9749043DBC08" modified="2016-07-06" version="1">MLHEKLEKYNSAFEKIMEELEEPEKPEDPKSSAPSTTDGTPKKTNSDGNGSKFRWQWEQIQLAMDANSISMEANQMSMGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AVE3</accession>
    <name>A0A163AVE3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein transport protein sec16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_75955</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SEC16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294121.1">
        <property type="nucleotide sequence ID" value="XM_018443108.1"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163AVE3"/>
    <dbReference type="GeneID" id="29004014"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_75955"/>
    <dbReference type="InParanoid" id="A0A163AVE3"/>
    <dbReference type="OrthoDB" id="8918678at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09233">
        <property type="entry name" value="ACE1-Sec16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024340">
        <property type="entry name" value="Sec16_CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12932">
        <property type="entry name" value="Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec16 central conserved" evidence="9">
        <location>
            <begin position="1005"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="8">
        <location>
            <begin position="1134"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="306"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="533"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="942"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1481"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1562"/>
            <end position="1879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="107"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="157"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="575"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="601"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="632"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="657"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="701"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="746"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="785"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1513"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1577"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1594"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1624"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1634"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1646"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1694"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1708"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1786"/>
            <end position="1795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD76081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1879" mass="206723" checksum="E0DDAC82378DC357" modified="2016-07-06" version="1">MASPHKDKLSPGWVDQNKNELNASHQSSPFGNPAQTNASTKNNSPVASQEENNSPHHEIVGDASALFGGTSNATDPFFSSITPAEDSSSFFDNVSAPAPEKAFDYTHQAQAHDTQYDYQSQKTYNHTTEANTTGQYYNPTQQAYDPSQQQYDPSQQTYNQSQQAYNHSHQAYDPSQQAYDPSQQAYDPSQQAYNPSQQAYDPSQQAYDPSQQAYDPSQQAYDPSQQAYDPSQQAYDASQQWIAFDPNQHYYYDEQGQLHFYDPNTNLDVDYQYPGTTEEYQFDPQYAQYYDQNAYAANDQVAVDQPAATSVAHSDAQPQSDSLATHPNTKPLHGTDSYLHDTQDYAQFEPSATVTNKSMPSFEAEHSHPPISTGVSFDKGETAGSWKDNSVFSPGEHEATVPTITQTTVTGAAEVPVMEEDEDELKGGLPMKKTESEQMNVFQNELGASDGYTSHQKEGFFYGDQVYKPEEHSVTLHKNDAEDQTRWDEQGESVNFNQYDHSYGSSEPVVSRNVSENNDKSILETDTTKEVDVFAHYGNNQTKEKLPEKDVENDLDDLVLGESDPTKGVQEHTTDYSNNMYNNSYEPHTQQDYSVAYSPYDHTSTISGDAENTPSYQNSYEPQTYQDNSTEYDARDITRTSGTTKKESSNEAHTKQDYSGQYDSLNTTSANHENSYEPYGEQNYSAQYDGYNPSTEDAENYDQNGSYEPQNNQDYSAQYDPNTNTTEQEPSYGYQSHQDHSTQYDSKNSSSTEKQSSYESQTHQDHSRQYGAYNAAPTDRVVPYGTSSPYEPPTTQDLSTNYNESDKNQSQLNITQHEKTSYEFSPHSKAEPSIPAIHRGSFPGTTQGYPVPFEGYNHSPMERSSTVPPPPISRMLTPRPDIPQPCPHPACEGENKARAKFCCECGRPLAGISRSTTPAAHSTQSFLSYTPINADLRSYAPTAMESSPPEAQRYTPNHLHPNTQDNQETAVRAFIPEHHSPYENAYTEVSAVDNGYGEELDSTVKSMSSFVGPVLFDAKLSAKAKKKEVLAYMDKRLADYDALLSDASNNGHALDDIENKTLLWKLVKVLIEQEGSLGDNDKMDAAVRGLLWPVTATTAEEDNANFSVPAYGQANPALTEGEDADYSEVVLNKLQKFLENGDREGAVDYAVQEDMWAHALVISSCVNKELWKKVTSEFIERELCATVESKQTRVYHNVMGDKQALRVLYALFAGSGAGSISEFVKTSDKHVTSHYGATPTTPSPVSVDQLRQWRETLLLILANRTPRDVEAITALGDILKAQGWIEAAHFCYVVSPQSSLHSGIDAPHVRFTILGADGSNISKDLDSIHLSELYEYALSTKQATISSLPFLQAYKLVYAWQLADYGFTSLAQRYCEAIAGAIKANTKRTPWMHRQFVERLEEFAEICEISSGNSLSGDAGSWLKTKLAKNSLDSLWGSLEGRFNKFVSGDDAPAAEPVGRKSTEIMADGLPARSVSAFDFRNGGRTSVGPEHMRRSATPTTTVTAEGVALERQMTSSPYSRAQSSFEVSRNATQSPAIGGQDKLNQGYGGYGGYGGYGTPGYSYGQEPVRPPTATYSPFQQGSAPPQAPGQAQNEYGYSPQTAPYGNNQSGGWWGADPGAEQPVESNIQQPDYQQQQQQQQQQQQAPSINTTSSYQPSNYAPSSTPATSTWAGGDDDDLGFGNSSLKKDKPAPSGTSDGPNNESTQNEPEKEEKPQETKQEKHGWGIFSLFSRSSAPAAKEDKKAIKANLGEQNNFYYDEKEKRWVNKLAENNTPAPAALPPPPKSSSVNPTRVSSPAGPPPPSQNGRASLAPPPPSGPTRMSSAPVPGSGPPLGGSSGISSPDFGTPPPLAGKRAMTTGGRKPMRSRYVDVFNQPPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DM13</accession>
    <name>A0A163DM13_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_92600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290290.1">
        <property type="nucleotide sequence ID" value="XM_018443794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DM13"/>
    <dbReference type="GeneID" id="29004699"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_92600"/>
    <dbReference type="InParanoid" id="A0A163DM13"/>
    <dbReference type="OrthoDB" id="2424778at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="89" mass="10332" checksum="22F41B4C6BF3658C" modified="2016-07-06" version="1" fragment="single">IAKKLNVSPYTVSRVLKHYKETDSYESVKNSGRPKKLDARDEREILREISKDPKQPMSVIRRSVTTPTSANTFRRVLRSHGIYSRKSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DYU5</accession>
    <name>A0A163DYU5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_167681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292300.1">
        <property type="nucleotide sequence ID" value="XM_018435691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DYU5"/>
    <dbReference type="GeneID" id="28996597"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167681"/>
    <dbReference type="InParanoid" id="A0A163DYU5"/>
    <dbReference type="OrthoDB" id="2285377at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="179" mass="20579" checksum="9A0CFE7C92865147" modified="2016-07-06" version="1">MHTKLRTRSFEKELVDLPEEARSIIDNVQLHWGDCIEFVGAPGTGKSPRMIKLAQLVASDSSQVVFVDFDCRIHLQPFENQYLYQPQDEAERYGVILGLRRWLSENTDSVVGWVFVDGWLDQELKRELVSCQAMWGFILVTSRQHTQIGSRVSTDSSVSTVRRHNQRNQCHSIVCLQMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EF84</accession>
    <name>A0A163EF84_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF300-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_107139</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296370.1">
        <property type="nucleotide sequence ID" value="XM_018427980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EF84"/>
    <dbReference type="FunCoup" id="A0A163EF84">
        <property type="interactions" value="181"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163EF84"/>
    <dbReference type="GeneID" id="28988886"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_107139"/>
    <dbReference type="InParanoid" id="A0A163EF84"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD78330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="48887" checksum="44AFC1FF7E1A63EF" modified="2016-07-06" version="1" fragment="single">MALLLADNGYGEGGAGSEFSLIAINLALIFTIVATCISMISVWLHWKNYRKPNQQRQVIRILWIVPIYGVSTFVSLVSLNVAFYVDTFRDMYEAYVIYAFFNLLLNKLGGERALIIMLHSRPPSENFFPGTLWSREIYVGDPYTFLFVKRGILQFVYVKPILAVVTMALKATGHYSEGEISWTSSYLYLTFFYNISVTLTLWCLMVFFYATKKDLVAFRPLPKFLCVKAIIFFSFWQSVVIALMVAAGMIQDEGPEHISVAIQDFLICMEMVPAAIAHSFSFSYEDYYDPDVHSARMPIYRAIRDSFGIKDVVMDTLDTLRGSQFNYRSFEPSEGVPHIGSSRTSRIMAGLRYSTSTAKKHWIDPAPTSRFISAGRALNEGRGGSGGGERGASGVEVYEPLEFDDPDPNDEVEDHYRTSRAMMFGDYNYPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JES7</accession>
    <name>A0A167JES7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_80127</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441027">
        <property type="protein sequence ID" value="OAD65856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283896.1">
        <property type="nucleotide sequence ID" value="XM_018443559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JES7"/>
    <dbReference type="FunCoup" id="A0A167JES7">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167JES7"/>
    <dbReference type="GeneID" id="29004464"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_80127"/>
    <dbReference type="InParanoid" id="A0A167JES7"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="171"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="235"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD65856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="354" mass="37948" checksum="3A58D5DE6EB04E60" modified="2016-07-06" version="1">MAERDVGLANYILQSIHKDLTFLRDQHYVSAQTYDSVVAQLPQHVDAKQSSPSSTPAFVKPPLPTRKSTTTLNSREPVAPSREQLFPKLPVRRSGEDRQPSPQPHHSPLPTPAPAPAPPVAAVAVLPPPTTTYTPPASAALPHQALGRAVQSFVTPPVVETPPPAYTSDPGVLATAEALYDYSGDDPSTDLSFRQGQTIQVTEYVNDDWWRGTLNGKSGIFPQNHVKKRPNPPATLAKAKRAVPPPAVKAATLPPSQSTSNVPYSYPPPPTAIYHNPPPATNIYHNPPPATTMITSAYPVPGTVQQQQQQQQPQAPEEENKVSNMAKKFGGHVATAATWGFGATLGSEAAHAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JHS9</accession>
    <name>A0A167JHS9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_152812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441006">
        <property type="protein sequence ID" value="OAD66006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284046.1">
        <property type="nucleotide sequence ID" value="XM_018433001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JHS9"/>
    <dbReference type="STRING" id="763407.A0A167JHS9"/>
    <dbReference type="ESTHER" id="phyb8-a0a167jhs9">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="28993907"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152812"/>
    <dbReference type="InParanoid" id="A0A167JHS9"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="8"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD66006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="569" mass="63705" checksum="16BB9689141DA1E8" modified="2016-07-06" version="1">MSELITTSVIPTSSGFVQGFVNPMHDIHTFLGIPYAYPPVGDLRFRPPVPFVDSSEEIKICMEHAPAAPQTQMPFDTLMSVEIDNQSEDCLYLNIWAPDTEPDSKRPVLIWFHPGACMSGSSSQVFWDGTNLARNDIIVVSFNYRLGALGWTRLDHLSSDFEGSGNLGLLDQIEAVKWVKENIASFGGDPDNLTAYGASAGATTIMAAILSPTAAGLFRRVVLQSPPMFMANPSDWAATKGSLMLHSLGVPKDDVGEMRDVDVQSFLEAQTFMTTWPNFLEGLAPIGPSVDGTVLPTTLMEHFLHKALPKGYENLEIMIGFTRDEFNFFFPFLPNFQDMDDSMFVRTYFSHIFGHKNARRAYEIYRDQIVPPSSPPSEVARYMASDVMCRVSTLLTAENLARHGHKVWLYEWDYESNDVENIIKAAHMVDAIYSWDNLEYWVDNPFLGPGDDVERDQIAKQMSRAIVSFARSGDPDHPGIPHWPAYCQPGKETERDGMVFDQEVRVERNIYDHGLALWKTQLKEYVRNQLCPIKAKEETASLSSTTDDAAKDVSEPEGSSGKKRKIDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JL31</accession>
    <name>A0A167JL31_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_175510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441005">
        <property type="protein sequence ID" value="OAD66218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284258.1">
        <property type="nucleotide sequence ID" value="XM_018437510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JL31"/>
    <dbReference type="GeneID" id="28998416"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175510"/>
    <dbReference type="InParanoid" id="A0A167JL31"/>
    <dbReference type="OrthoDB" id="3248986at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="389" mass="44703" checksum="372AACF0FE1ADCE7" modified="2016-07-06" version="1">MHNLFLGTAKRMMDIWIATNLLDDKDLVEMQEEANRMVLPVGYTTLKIKIGKKFPFMKADEWKSWCLIYSPVLLKTRLRDDLLGNWIHFVDACRELTKPSITKNGIKKAHESLEEFCVGCEDFYKPDVFTQNMHLHLHLKETIEDFGPIYGFWLFSFERYNGVLKGFETNQKSGFENTYMKRFLESSYNGDFCQAHLRNVTSPLLLSLFLKLSGCKIYNPALSPHPLIPSFFHLPTFLQSTEKPSKQTFGNESLPLSALPLCLKPPTTRRKSEYDCRLDFYKIEYDDDSLCSAKTTIRNCWFVNDRIQKISSINLLGQVYTGGEVETLRKDMLVVLSTCSCTILHQTSRTPTFSLVTTPNTYLPSLSGTKFLAINLESSRALSCMSQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JNT1</accession>
    <name>A0A167JNT1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP-dependent DNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_70846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441003">
        <property type="protein sequence ID" value="OAD66386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284426.1">
        <property type="nucleotide sequence ID" value="XM_018442347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JNT1"/>
    <dbReference type="STRING" id="763407.A0A167JNT1"/>
    <dbReference type="GeneID" id="29003253"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70846"/>
    <dbReference type="InParanoid" id="A0A167JNT1"/>
    <dbReference type="OrthoDB" id="3691720at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274">
        <property type="entry name" value="DNA HELICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274:SF51">
        <property type="entry name" value="OS03G0423850 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="29437" checksum="92CD6FFFD53DE574" modified="2016-07-06" version="1">MTPSGPICASCKQLGHSRGSNFSCPLNPRHKTLLIPQKRTSDNLSAQEEYQAETGALRPRVEAVQSCVVLTIAEIIALSCAAQYPAENLTAAFEAFQVSDVERVLDLTTTTATAIATVIPRCSSCNGIGHQRINYHSQHGPAYYPLCNGTRLICNDFGRYVIKATIVTGSSAGKVVLIPRIKLNPNGSTMSIEFKRCQFPVHLAFAMTINKFQGQILDKVGLYLPHHVFGRGQLYVTLSQVRTPNSVKIMVDMGSISTEATSNVYKQCCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K1I0</accession>
    <name>A0A167K1I0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_174766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD67059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285099.1">
        <property type="nucleotide sequence ID" value="XM_018437331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K1I0"/>
    <dbReference type="STRING" id="763407.A0A167K1I0"/>
    <dbReference type="GeneID" id="28998237"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174766"/>
    <dbReference type="InParanoid" id="A0A167K1I0"/>
    <dbReference type="OrthoDB" id="2389915at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="733" mass="81995" checksum="4044486149599EAF" modified="2016-07-06" version="1">MSSNSILDSYQCNQCKERHTNLKKAKSCRAQCFKNRHRRHNDIQTSQTTPVPGQVSVVLNTVSNDTIDRERADAIEDQIMDTLNSEDNDDPIMNIFSNDDNDESMYDAELGNDMDIIENETSPLVFDFSQPAPTSDKDDAKNLEFLKIIKDFGISRNAHEMIVKHFNSILETSTCITYRACTPHLGKKLLKRFSGVEETVHDICQRGCMLFTSPSQTECSNCGQSWYKTRRGETEGGDLVAAATMIQLPLARQLALATLPSINIRTLESFQNFSQASASSRKGLNGQSPLATLKVFSGPLFFALDEMHGLCHGISKQIWGLVSGTYGTDHCFALSSGVRKEIGTAMYKTRNTIPTSFHGNWRDVYKNPRLFKAVDWADFLLFIIPTLVAERIGDATARNALLGLVQACNLLMSWELSAEKQTSIKSKLEIWNMYLESLLTSGKIKINIFTINQHLLQHYPLMIDAYGPPHAYSARSVERAIGEYSRAIKSNSAINVNAGNIMLGLAQIRQAEAGATVMITEARTARHLQYEDSTAGWPLTDEGERVGAGSDIEFWGPLRNRTIQDSFEGISCLSKLLEDFYESKGEECSMIEAAIQTSRKAFVNGCVIDSALDQNCVREAHNIRLQIQVDENRNINSAYSPVYKDFFRKVVVFFEHKLNKKRWPLALVEIAAVRLVNGIPVVNNGQMKPKVVHLAGVKELVGRKHSHKSKKPPFFPVVIYLMTSASYVYIKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K3I9</accession>
    <name>A0A167K3I9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_57534</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the THOC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441025">
        <property type="protein sequence ID" value="OAD67200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285240.1">
        <property type="nucleotide sequence ID" value="XM_018440242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K3I9"/>
    <dbReference type="FunCoup" id="A0A167K3I9">
        <property type="interactions" value="616"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167K3I9"/>
    <dbReference type="GeneID" id="29001148"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_57534"/>
    <dbReference type="InParanoid" id="A0A167K3I9"/>
    <dbReference type="OrthoDB" id="340259at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000390">
        <property type="entry name" value="THO complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040132">
        <property type="entry name" value="Tex1/THOC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3 THO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25174">
        <property type="entry name" value="Beta-prop_THOC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="10"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="55"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="180"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD67200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="311" mass="34964" checksum="10C2F6272AE48653" modified="2016-07-06" version="1">MFDNSKIKEYKGHKEKVHTVAWNCDGRRLASGSVDKTARVWTPHRGTDIRYSIELKGHTDSVDQLDWDPTHPDRLATASCDKTARVWDQRSGKCTAVVQTGGENINICWSPDGNNIAVGDKSDTISIIDTRTYTIAKTQKHNVEVNEIAWNNANNLFYVTTGQGTIKVYEYPSLKLLQSLRGHTANCYCVEADPTNRYLAVGSADAMVTLWDMEKYTCVRAFSELTWPVRTLSFSYDGQFIASASEDNFIDISHVESGESVHHIECTAAMNTVAWHPRDYFLAYAGDEMNSEGKYAGNLKIFNIKDPRETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K6L7</accession>
    <name>A0A167K6L7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_98666</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285417.1">
        <property type="nucleotide sequence ID" value="XM_018444067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K6L7"/>
    <dbReference type="FunCoup" id="A0A167K6L7">
        <property type="interactions" value="1125"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167K6L7"/>
    <dbReference type="GeneID" id="29004972"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_98666"/>
    <dbReference type="InParanoid" id="A0A167K6L7"/>
    <dbReference type="OrthoDB" id="417252at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21378">
        <property type="entry name" value="eIF3E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03004">
        <property type="entry name" value="eIF3e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019010">
        <property type="entry name" value="eIF3e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09440">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21357">
        <property type="entry name" value="EIF3E_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016255">
        <property type="entry name" value="eIF3e_su6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01186">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="220"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD67377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="419" mass="49013" checksum="45E7C282F3DDEEF8" modified="2016-07-06" version="1" fragment="single">MAAAHDLTLRMIPFLDRHLVFPLIEFLELNKVYPAEDLLKAKYDLFNNSNMVDFVLDLYKKIHNTEDTPQEFVDKREVVLNRLEELQGEVQEVMTILEKPEVIAALRSDKAQNLNYLKENYNLTENRINILYEFGQFQFSCGDYGGAADMLYHFRVLSTDTERAFSASWGKLAAEILTGNWEAALEEMQNMREAIDQKSFSSPLHQLQQRSWLIHWSLFVFFNHPKGRDGIVDMFLSPQYINTIQTSCPWILRYLATAVVTNKRRKNQMKELVRIIEQEAYEYKDPVTEFIEALFIHFDFEGAQKKLKECEDVLSNDFFLAATQEDFMESARQFISETYCRIHQKINIKDMSQTLNLNQEEGEKWIVNLIRDTRVDAKIDFEENTVIMNTPVTSIYQQVIERTKGLSFRSQVLASAVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K9Z9</accession>
    <name>A0A167K9Z9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycogen synthase kinase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_178331</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Protein kinase that acts downstream of the MPS1 MAPK cascade as a highly conservative signal modulator that dictates growth, conidiation and pathogenicity. Phosphorylates HAT1 at 'Ser-8' to block its translocation from the nucleus to the cytoplasm where HAT1 positively regulates appressorium development and pathogenicity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285607.1">
        <property type="nucleotide sequence ID" value="XM_018437977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K9Z9"/>
    <dbReference type="FunCoup" id="A0A167K9Z9">
        <property type="interactions" value="487"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167K9Z9"/>
    <dbReference type="GeneID" id="28998883"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_178331"/>
    <dbReference type="InParanoid" id="A0A167K9Z9"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000009">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000082">
        <property type="entry name" value="Shaggy-related protein kinase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0309">Germination</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="38"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD67567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="394" mass="44370" checksum="005D78A50877512F" modified="2016-07-06" version="1">MAHGPMSGLKIIGDADPMKVIKVAAKSGKTGEDIQLHYSNYKVAGNGSFGVVYQAKLLRTGESVAIKKVLQDKRFKNRELQVMKSVSHPNIVTLKAYFYSQGDLKKDEVFLNLVLEYIPETVYRTTRHYAKAKQHIPTLHVKLYTYQLLRALAYIHSLGICHRDIKPQNLLLDPASGVLKLCDFGSAKMLVANEPNVSYICSRYYRAPELIFGATNYTVSLDVWSAGCVMAELMLCQPLFPGESGIDQLVEIIKVLGTPTKEQLLAMNPEYTEHRFPQIKAHPFVKVFKARTPVEAIDFISELLQYAPEKRLTAIDALVHPFFDELRDPAARPVTGKEMPKLFDFTAHELSIKPELIKKLVPPHCEAELLARDIDINHFQPLLLDDLKRAAVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KCU9</accession>
    <name>A0A167KCU9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_151314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285825.1">
        <property type="nucleotide sequence ID" value="XM_018432664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KCU9"/>
    <dbReference type="STRING" id="763407.A0A167KCU9"/>
    <dbReference type="GeneID" id="28993570"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151314"/>
    <dbReference type="InParanoid" id="A0A167KCU9"/>
    <dbReference type="OrthoDB" id="10550160at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="113" mass="13007" checksum="AD6634CFD8FEDA99" modified="2016-07-06" version="1">MATFNIAANYNNHIIPDYIESVDSFDLSSEDEFTNYHEKNTVFVGKPLENPLKPAQKRITTTKSIKIGYSASIYKHTMTDGTACIKYNWQHPNHDPFKIEEISLSRLPDELKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KEU1</accession>
    <name>A0A167KEU1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPI inositol-deacylase</fullName>
            <ecNumber evidence="10">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_127912</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="10"/>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285967.1">
        <property type="nucleotide sequence ID" value="XM_018429195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KEU1"/>
    <dbReference type="STRING" id="763407.A0A167KEU1"/>
    <dbReference type="GeneID" id="28990101"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_127912"/>
    <dbReference type="InParanoid" id="A0A167KEU1"/>
    <dbReference type="OrthoDB" id="348976at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="11">
        <location>
            <begin position="76"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD67927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="360" mass="40161" checksum="C0997D9A875BD36A" modified="2016-07-06" version="1" fragment="single">MTCLSKTQWILCILMGLSALAIHVILDAFYHPYDPPACSMSYARPSYHQIPNVVSRLSEKYTLYLYREVTVDREDLSGVPVLFIPGHAGSYKQVRSIAAQVANHYYYEIPLHEGSASMDIFTVDLNEEFSALSGQLLQDQAEYLNSAVSRILEFYPSASSVMVLAHSMGGIVARTMFTLPNYQPGNINTIITLATPHATAPLVLDPTLDRLYRSMETFWKEGYANGTLNDVSVISLAGGSLDTTVNSDSASVADWVPESHGLTVFTTAIPNVWTGCDHRAILWCNQLVKVVAAMMAEVVDQRKPQQTIPVEQRMAVFRRHLGLRPQTHPWVHSSSLRNLQLRTKINQRGPTKRQGIRILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KF84</accession>
    <name>A0A167KF84_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_188917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285999.1">
        <property type="nucleotide sequence ID" value="XM_018439583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KF84"/>
    <dbReference type="STRING" id="763407.A0A167KF84"/>
    <dbReference type="GeneID" id="29000489"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_188917"/>
    <dbReference type="InParanoid" id="A0A167KF84"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="39"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="310" mass="34328" checksum="9283759D3BDA70FD" modified="2016-07-06" version="1">MSGLTSILRESGHVSVATKRESTPVNIYYEMYGYGEEKVLLVMGLATPCQAWDNQIKFLTQTGKFTVLIIDNRGMGHSDAPVGLYTTKQMAADASDILDHFGWTSNVHINGVSMGGMISLELVHSQPERFASLTLTSTTATLNIPTLKAVTTISNLLLLSNEPKSRISVIVELLYPKEWLASKPSDPTLGFNTNRELASHRLVEHAKLSKLQTLQGHIGQLSACMRHYVSDKRLLFIRNNGPPVLIMTGTWDNLVRPRYSHLMHNVLGGHLEVFNGSGHALPEEQVDKYNKLFFDHMSAATQNKTVASNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KFF4</accession>
    <name>A0A167KFF4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_68348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286016.1">
        <property type="nucleotide sequence ID" value="XM_018441934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KFF4"/>
    <dbReference type="GeneID" id="29002840"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_68348"/>
    <dbReference type="InParanoid" id="A0A167KFF4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="105" mass="12071" checksum="313E97B7028008B5" modified="2016-07-06" version="1">MCNIMSRDWIQYPQLCFCTFRIFGGIIIILVEGLFEDRQQIRIIGNTALNNQLVDLANGVKNKRENEKKRIKISDQIVGEQGDRSMDYGRGGDVDQLQHQICNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KTF5</accession>
    <name>A0A167KTF5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_149840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286869.1">
        <property type="nucleotide sequence ID" value="XM_018432349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KTF5"/>
    <dbReference type="GeneID" id="28993255"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149840"/>
    <dbReference type="InParanoid" id="A0A167KTF5"/>
    <dbReference type="OrthoDB" id="3039677at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="328" mass="37086" checksum="06CA2A2827EC85A0" modified="2016-07-06" version="1">MPSIPNLTMKTISTHQSGITEEAYVQTSSPFWEDASMSDDNNVLVGNKEIHNSENNSDVSSNDEESSGDDENSNDKENKDDDKDVVEIKVEEFVDEDPFATPNMSESLVHRFIAKFVVMFASRYVINKGTVVLIEFINKLLTIYKQDFQLPLSLPGLQCMTGFSAMTKGVKKFVVCQDCYKVYEESVSAPFHCDFVKLDKDSVQFVQDSRSLMLTINIDWFQPLNNVSHLSGAIYIAIDNLLQNKQFESENIILVRLMLSPKKPKPEEINHYLKPLVDELETLYVGMKIPTFECPSGINVCAALLMVVCYIPAAWKTSWLCDISDTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L271</accession>
    <name>A0A167L271_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_66610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287466.1">
        <property type="nucleotide sequence ID" value="XM_018441664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L271"/>
    <dbReference type="GeneID" id="29002570"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_66610"/>
    <dbReference type="InParanoid" id="A0A167L271"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="309" mass="35596" checksum="B08C182A23A9C563" modified="2016-07-06" version="1">MSDINTTLLNSIQKIEIDLAEIKQALRELQRQFSNQFAPAVSAEDLTTMQQSIIEQRSLERIAKSVKRAQLTECPDQLGKQVINTGGEFKEKNEAQKYNLLLQILHEQDWKAHCKEVPQGQPLPPLVPLSDHDLTVKRLHLKTLGRTVKHDIIDKDYPAASKEWKNIPEKNREYYMMHLERLAKNGGLHIHQCKRMWCARSLLRESFKSDNQMHKRRMAEKNKTQQDISDSSLSSPDMSETGDVESPIMADVLSPPPTASVEPACKRSRRSVNAYFTEQVSILYKEIEYPKYMKYNLNSTVLLHMFCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L4F1</accession>
    <name>A0A167L4F1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_172211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287615.1">
        <property type="nucleotide sequence ID" value="XM_018436754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L4F1"/>
    <dbReference type="GeneID" id="28997660"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172211"/>
    <dbReference type="InParanoid" id="A0A167L4F1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="141" mass="17060" checksum="89F3A0277C74BE6D" modified="2016-07-06" version="1">MWFDVKLSGVTVKELYLRQWVYATRHSKYRINCMIKYKAYFNMCGKLVADNISRFIIEFPKYSLFEFYSVFFLFSTAHNSVMVDQIIKSIFNRFFEYIRCSRRVPFSGSQDFLFIYIKNDGNTQQQPTMLYSIYQYFLSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L8U7</accession>
    <name>A0A167L8U7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_182651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287895.1">
        <property type="nucleotide sequence ID" value="XM_018438653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L8U7"/>
    <dbReference type="STRING" id="763407.A0A167L8U7"/>
    <dbReference type="GeneID" id="28999559"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_182651"/>
    <dbReference type="InParanoid" id="A0A167L8U7"/>
    <dbReference type="OrthoDB" id="674948at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40129">
        <property type="entry name" value="KETOPANTOATE REDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40129:SF2">
        <property type="entry name" value="KETOPANTOATE REDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="31275" checksum="E3FFFB8F6B95F081" modified="2016-07-06" version="1">MEQQVLTTALPMLILGLGWTGQFLVELLNAINLKYAATTRDGRGNTIKWTMPSTSYWATNPTGLTNLPSAQTVLITFPVINTSEMTEFMDAYESEHGKPQWILLSSTRPFNGTPSDRHGPMDPSRGTDRSGAEEIVLSRGGTVLHLAGLWGAARQPRQWVSRFPTEAAIRAKLLTRQLHLIHGKDVARAILAVHEQFKSGERWIVTDKGCYDWIRLFLAWGSPEQIAIARSLAKNDEVCRNALGEGTLEDVVARGGVVPRLNSNEFWETFGIEPTEYLTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LFI0</accession>
    <name>A0A167LFI0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EngB-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_182584</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288378.1">
        <property type="nucleotide sequence ID" value="XM_018438644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LFI0"/>
    <dbReference type="STRING" id="763407.A0A167LFI0"/>
    <dbReference type="GeneID" id="28999550"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_182584"/>
    <dbReference type="InParanoid" id="A0A167LFI0"/>
    <dbReference type="OrthoDB" id="391988at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00321">
        <property type="entry name" value="GTPase_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019987">
        <property type="entry name" value="GTP-bd_ribosome_bio_YsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03598">
        <property type="entry name" value="GTPase_YsxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47560">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47560:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EngB-type G" evidence="8">
        <location>
            <begin position="148"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD70338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="341" mass="38644" checksum="74DF7DD39B4B0E0B" modified="2016-07-06" version="1">MQPWKTFHSFANNARSPLCRPLKNKACCPLGSQPSFRSLNTKPTSALTLNKPTAPKPKHPKPAGTVKTDENELSNRQKFNRVEPSARVYEKLEKLGFGTLRQTKRFSIVRGKQKPVSEKDGPPDPEYSFPLLSFFAGAKTPASFPPESLVEIGFVGRSNVGKSSLINSLAESTVVRTSDKPGLTQQINFFSAGSLFHMVDMPGYGFAFVDDAERQQWRDLMENYAEKRTILKRLFVVIDARHGLKVADHDFLQMLDSKKVRFQIVLTKCDLQVLPILARRVMVVQESIRTYRHSVKDVLVVSSKTGSGINQMRKEILFLTGKLQPREFYKPKKEEVPQKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LGV8</accession>
    <name>A0A167LGV8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cation-transporting P-type ATPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_115367</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288469.1">
        <property type="nucleotide sequence ID" value="XM_018428456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LGV8"/>
    <dbReference type="STRING" id="763407.A0A167LGV8"/>
    <dbReference type="GeneID" id="28989362"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_115367"/>
    <dbReference type="InParanoid" id="A0A167LGV8"/>
    <dbReference type="OrthoDB" id="158672at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000095">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="876"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="938"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="981"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1012"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="10">
        <location>
            <begin position="21"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD70429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1051" mass="116633" checksum="C85F8F1364D4D570" modified="2016-07-06" version="1">MTNCLIFNFTNLIVLDLTNVNYHNLSILELSQQYSTSIERGLDKEQATKRSAQYGKNAISPPPSNWGKKLFNYFFGGFCSLLWFASIICWISWKPLGNPNPAPLNLALAVILMFVVFLQAFFNAWQDWSTNRVMHSINNMLPTQTLVQRENNVITIDAVGLVPGDIVHVKMGNKIPADLRLIEVSDDLKFDRSVLTGESEAIPGTVDATDSNVLESHNVAMMGTHCLNGSAVGVVVAIGDNTLMGRIARLSLADNGARTLLQIEILRFVIIIAVLSITVGAACIITWAAWLRVSYPDFLTVSNALIAVISVIVAFVPEGMPVAVTLCLTLIANRMKRNNVLCKVLTTVETLGSVNVLCSDKTGTLTENKMFVSDACIYNEYLASHVCRDVLVQRDIEVVNKYALSHQVGHLQAVSALCNGSRFDPETMHEQVRLRKTFGDATDSAILRFAEQTNPSSTVADCREKSEKIFEIPFNSKNKWMLTIHRPFHPDMANALSSNTTHVSTDDWVLICKGAPDVLMNRCTHVILPDGVEEPLTDKRRELLEEVQTRWANDGKRVLLLARRVIKASDTPNNIQAGTSSFGAWATQMNQNLVVIGLLAIVDPPRADSAETVKICRRAGIRFYMVTGDFPTTAAAIARQIGIFTTAHPKTIKDLDPSRPIDQIPRYIQTEFNNSSSIELTQKGSSETTLEDSTSLLLSGTDLITLNDNQWEQVCQFEEIVFARTSPDQKLRIIKEFQKRDNVVAMTGDGVNDAPSLKAADVGVAMGGGSDVAIEAADMVLLDQFSSIIAAIENGRLVFDNLKKVILYLLPAGSWSELWPVVVNIFFGSPQTLSSFQMIVICVLTDLMPSMALMMEKPEAGLLTRLPRRPKQDRLVNARLLMQAYGFIGIMEMASSMFMFYLYLGMNGLPPNKVFFSFSNFNSPDGYMGYTASEISSLLYTAQSIYFVNLVICQWGNVLSTRTRRLSLFQTNPLWGPSQNLYLFAAMIGSLIIALIILYVPVFNTYLQTSPIPVKFWFIPFGWAGMIMAADETRKFLARTYPKGFFGKLAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LJN9</accession>
    <name>A0A167LJN9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Basic-leucine zipper transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_69555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288646.1">
        <property type="nucleotide sequence ID" value="XM_018442116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LJN9"/>
    <dbReference type="GeneID" id="29003022"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_69555"/>
    <dbReference type="InParanoid" id="A0A167LJN9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031106">
        <property type="entry name" value="C/EBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23334:SF20">
        <property type="entry name" value="BASIC LEUCINE ZIPPER 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23334">
        <property type="entry name" value="CCAAT/ENHANCER BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="64"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD70606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="134" mass="14650" checksum="478C4F0934BFE676" modified="2016-07-06" version="1">MLNQTAANFASFTTTTIVATATLHTMPSTIPAIIPATIPASIPVPIPVSTSTSTNVHMDTHSLREERNRKNRAAVAKSRAKQKALARSLEEKLGKREIENEELRGTLAGLKREAEELKELLCLSTMLCIFEHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LW32</accession>
    <name>A0A167LW32_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_66506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289249.1">
        <property type="nucleotide sequence ID" value="XM_018441652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LW32"/>
    <dbReference type="GeneID" id="29002558"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_66506"/>
    <dbReference type="InParanoid" id="A0A167LW32"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007890063" evidence="2">
        <location>
            <begin position="26"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD71209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="338" mass="38088" checksum="6F25AD8C0A3950BD" modified="2016-07-06" version="1">MSPLSVSPCITGLFLLSLKVGVARALSSYQWTYYLLPVELSLRLPITQVPFVAGEFITSTGWSIYLTGRSPLSHWRACCFLLLIPTIKLLLVGDKTVPFLPQNFPLLRDLCSPDRKPIWLPTQAQGQSQGQKSKSRRIVKVKVKNQNRDAESKSRSKIKIKIETQSQSQDQKSKSKSTVKVKVKNQNQDARLRSRIISEYQVKSQVKSQVQYQNHSNGQVKFQVKFQVNAQVIYQVISQVISQVISQAKVQVKVQVQVQAHVLAHVLAQAHTQSRKSPFSIFIQIKNPGHALQISMSSSFPRRVSTQVPNQEKGDHLTQSQSQNSGFIFKAQLLSRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MB97</accession>
    <name>A0A167MB97_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Secreted endopolyphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_65598</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290394.1">
        <property type="nucleotide sequence ID" value="XM_018441492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MB97"/>
    <dbReference type="FunCoup" id="A0A167MB97">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167MB97"/>
    <dbReference type="GeneID" id="29002398"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65598"/>
    <dbReference type="InParanoid" id="A0A167MB97"/>
    <dbReference type="OrthoDB" id="348678at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045473">
        <property type="entry name" value="ASM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF55">
        <property type="entry name" value="ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19272">
        <property type="entry name" value="ASMase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007890229" evidence="10">
        <location>
            <begin position="18"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="11">
        <location>
            <begin position="63"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingomyelin phosphodiesterase C-terminal" evidence="12">
        <location>
            <begin position="406"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD72354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="504" mass="57356" checksum="406272AC4CB04B73" modified="2016-07-06" version="1">MYSLTLVLLGGFSVCLALILICQPPSIYLLRGITNGPLVSHSFEKWESHLLPVNPLPRQHGYFLHITDMHVDENYVSGATVESACHKLAKESDVTSQVAGPLGAPGAKCDSPARLAQETLEWVARNWRDKLDFVVWTGDSARHDYDKSRMRKRKDIYTLNRQVTDMVKKAFWSPHHPVLPVVPCLGNNDVFPHNAIDEKDHDLLSFYEKLWRPWIPTGQRKSFRQGAYFATQVAPHLRVLSVNTLLFFNRNPLIEDCGSKNHPGDVQLAWMEDQLRLARREKAKVYIMGHVPPSARDFRPTCLDNYMATVSQYSDVIMGQFFGHLNMDHFMLYDASQPTNQTFRQTDEDKGGDLHATRDITEYVSWLRDMYSALDPVTSDPNKLPDYPASPLVVLQVAPSVLPIYWPAIRIYRYETNPSASNYGTLLGYAQYHANQASYDAVPGKPLEYQLEYTTDTLYGMPDLSPKSYHALAKRMVMGDAIGNATWTAYIRNMFVQARNNEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MY48</accession>
    <name>A0A167MY48_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_67599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018441817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MY48"/>
    <dbReference type="GeneID" id="29002723"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_67599"/>
    <dbReference type="InParanoid" id="A0A167MY48"/>
    <dbReference type="OrthoDB" id="2436053at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="225" mass="25650" checksum="F5A246C2E9F6ED1A" modified="2016-07-06" version="1">MPNSFCIEDLLYVSYYKNKIPDQVGPSIHKFWLVQIVELSDIRRGKKSRNRFYWRFYCSRSFHFYFEKKSCYNVRQVLQLNILESLCLILELVYRAHHKTGSLKQKMLQTLPFILITLITGVVSQNCPNGEGYYCGIGVAKDAMSLYICTELNGWQISEVCQFGCEENLPGFPDHCFQPVSPSGYEETAQIISASNDTVTQTASTSAEESINTEVPQPDTVTPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NBI7</accession>
    <name>A0A167NBI7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHYBLDRAFT_143849</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293644.1">
        <property type="nucleotide sequence ID" value="XM_018431083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NBI7"/>
    <dbReference type="STRING" id="763407.A0A167NBI7"/>
    <dbReference type="GeneID" id="28991989"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143849"/>
    <dbReference type="InParanoid" id="A0A167NBI7"/>
    <dbReference type="OrthoDB" id="5566853at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013958">
        <property type="entry name" value="DASH_Dad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28025">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28025:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08649">
        <property type="entry name" value="DASH_Dad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAD75604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="78" mass="9040" checksum="22EE3834CD42BFA0" modified="2016-07-06" version="1">MDNRTSFENEYDALMDQAYQGFDQLLYNMNLLNKNLETLDAIGREFQQPAKLWESFHRGIAVPAPQNSGWSTLMNVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NEZ2</accession>
    <name>A0A167NEZ2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_180852</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293784.1">
        <property type="nucleotide sequence ID" value="XM_018438370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NEZ2"/>
    <dbReference type="STRING" id="763407.A0A167NEZ2"/>
    <dbReference type="GeneID" id="28999276"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_180852"/>
    <dbReference type="InParanoid" id="A0A167NEZ2"/>
    <dbReference type="OrthoDB" id="407010at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF24">
        <property type="entry name" value="CAROTENOID ISOMEROOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="588"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD75744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="602" mass="68243" checksum="74153BAF1B03C31C" modified="2016-07-06" version="1">MIILFSFIIALLTMVWVNPFGLVSRFTTYFNGQDLLAAAQTTVFRNTPEKRTPEWFPVKGRVPDWFNGIMYRVGPGKYNIEQANGTTFAINHAFDGMPFMHRFEISSERQAVRYNSRNISEEFESSIAKDNGQGKIFFGHQPTVTSVKQRLKDIYLRFDSMLLSRRPLDETSPSSQPVGVTATPNFPIPPVYKAADKNNGESDRVLVAKTDANMLQQLNSDTLEPKRLFNYGNFEKKLKGDLSAAHHQYDPITKETINFVLDMFPARLQVFSSTPEGKITILADFTHRLDEKRTRVQPVYIHAFNITKDYIILPEYSLAYTNMGVDFLVSGAVNTGMAWSNDRPTFFHVISRHGKGLVASVPVETFFSFHVANAWDSVDAQGRQVIDMDICAFENADIMCQLHTFAKPVRQAEYDSHVKKQLELSKQSQQYNGMNIPPLRQPSFGDLRRYQIVLENGTGEATYRTIASNVEFARYSQDYAMRKHKFVYGCQLISVTAKSNERYDLVKVNLDDGSVIRYSQEGCACSEPIFAPRPGGTEEDDGVLMSLVNKLDKEDPSKDYCFLLLLDAKTMQEVATCQVGQFTATTFHGSFVDHHFENVSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NKF1</accession>
    <name>A0A167NKF1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHYBLDRAFT_74350</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294178.1">
        <property type="nucleotide sequence ID" value="XM_018443013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NKF1"/>
    <dbReference type="FunCoup" id="A0A167NKF1">
        <property type="interactions" value="322"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167NKF1"/>
    <dbReference type="GeneID" id="29003919"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_74350"/>
    <dbReference type="InParanoid" id="A0A167NKF1"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23284">
        <property type="entry name" value="beta-trefoil_MIR_PMT2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000012">
        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="234"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="646"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="671"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="702"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="341"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="406"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="470"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAD76138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="749" mass="86522" checksum="1B9195080DF34355" modified="2016-07-06" version="1">MDNLKRRNIPQVAIPVEARNIDDYVPLDSQDVDSQSYSEKDKTSKPPPRIVYSSNKYIAFAQEHYKALTLAGLTLLSFWTRFRLIGWSKVVVWDEAHFGKFGSHYLEHDFYFDVHPPLGKMLVGLSGWLAGYDGSFSFDSGQEYPENVNYTVMRLFNAVWGALMVPLAYATAEEMGMSYKACILAGTMILLDTAYLCISRFILLDSMLLFFTCTSLYCLSVFHNLREQPFSESWWLWLSLTGVSLGCVSSVKWVGLFAVALVGVYTIQELWDMLGDVQMPKAKYVGHWIARIICLICLPVAIYLFTFALHFALLYKSGPGDAQMSSLFQANLAGNNFEQNPLEIAFGSKLTLKNYGYGGGLLHSHVQTFPEGSKQQQVTCYHYKDDNNHWILKHPRGIDIDDEAPVEFVRNGDTIRLVHEPTERNLHSHPINAPITTNQWEVSCYGNETVGDNQDNWVVEIVDDMIHKDLDRIRSLTTRMRLRHAQLGCYLAANNVILPQWGFKQVEVVCDKRNRPEDPHTWWNVEEHWNDRLPAAPKNAYKSKFLQDFWHLNVAMWTSNNALVPDPDKEDILSSEPTEWPLVSVGLRMCGWGDDQIKYFLLGSPAVWWTSFASLIVFIGTFLFYIIRMQRKINDLSYDQWNQFTYVGQTLFLGWFFHYIPFFIMGRVTYLHHYFPALYFSVLMVPFLLDHFTAKLSQRNQWIVFGVFYLFVIVVFIYLAPIAFGMEGPIGDYEDLEWFDSWNMLEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P135</accession>
    <name>A0A167P135_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ornithine decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">odc1</name>
        <name evidence="11" type="ORF">PHYBLDRAFT_131816</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="6"/>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295084.1">
        <property type="nucleotide sequence ID" value="XM_018429443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P135"/>
    <dbReference type="SMR" id="A0A167P135"/>
    <dbReference type="FunCoup" id="A0A167P135">
        <property type="interactions" value="316"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167P135"/>
    <dbReference type="GeneID" id="28990349"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_131816"/>
    <dbReference type="InParanoid" id="A0A167P135"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="10">
        <location>
            <begin position="68"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD77044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="430" mass="47855" checksum="B85BB0CD6F0B2865" modified="2016-07-06" version="1">MHTELDTIVLNQRCDSPMVSKTLETARLPNIPVLSVSVKDAIKQKLDSISQLKWESDQENAFVVGDIGEVYRQFLRWKALLPRIEPFFAVKSNPDPMVVKLLQSLGLGFDCASKAEIQIALETGADPSRIIYANPCKQASYIRYAAQQNVAKMTFDNADELYKIKKFYPNAELVLRILTDDSKSLCQLGIKFGAPLDTVDHLLQTAKDLDLNVIGVSFHVGSGCYDQYAFSEAVNLARGVFDKAEAMGFNFSLLDVGGGFPSADVTDGVTFEKIAAVLGPTVDALFPPNIRVIAEPGRYFVASAFTVCTNIIARRSKINNEQPSFMYYVNDGMYGSFNCIIFDHQVVQPHVLAKDGHFAYGEELEEKHYECSVWGPTCDSIDCLNKKTTLPLLSEGDWLYWNNMGAYTVCSSSQFNGFKSPEILYTNTYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P785</accession>
    <name>A0A167P785_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_17272</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295428.1">
        <property type="nucleotide sequence ID" value="XM_018436862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P785"/>
    <dbReference type="FunCoup" id="A0A167P785">
        <property type="interactions" value="292"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167P785"/>
    <dbReference type="GeneID" id="28997768"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_17272"/>
    <dbReference type="InParanoid" id="A0A167P785"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000007">
        <property type="entry name" value="Mitochondrial tricarboxylate transport protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="8"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="111"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="208"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD77388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="300" mass="32430" checksum="652900699FDE954B" modified="2016-07-06" version="1">MATDKKSKDPILSILAGTFAGGIEGVVTYPTEYVKTRLQLQAGGKLGPGEVRFKGPIDCLVKTYQSKGIGAIYTGVSALAIGNAAKAGVRFLTYDQIANQLKDENGKLTGIRSLLAGLGAGMTEAVLVVTPSETIKYLIHDKNSQTPKYKGLVHGTRLIIKEEGLQGIYRGVGPVMARQGANSAVRFSCYSSFRELLEKWHNKPGQPLPSTHTFLAGAMAGIVTVYTTMPLDVVKTRMQGLDAKIYKHSLDCLIKVVKQNGIFSLWKGTTPRLTRLIFSGGIVFTIYEKVYNGLNTLKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PC12</accession>
    <name>A0A167PC12_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_164535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295674.1">
        <property type="nucleotide sequence ID" value="XM_018435028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PC12"/>
    <dbReference type="GeneID" id="28995934"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164535"/>
    <dbReference type="InParanoid" id="A0A167PC12"/>
    <dbReference type="OrthoDB" id="2429120at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="111" mass="12702" checksum="70D8DBCC34EB485C" modified="2016-07-06" version="1">MPKFKSSLIETIKIFAMTCSCTRRDHFTSLEGESSLGPDTKFYKTIDGIRLDCLLIEVKCPNSTSDDDLFKLSIEMQYTLNRLVEHGVDNPDVYGVLVYSLKETNQRKNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PK15</accession>
    <name>A0A167PK15_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_164979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD78104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296144.1">
        <property type="nucleotide sequence ID" value="XM_018435125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PK15"/>
    <dbReference type="GeneID" id="28996031"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164979"/>
    <dbReference type="InParanoid" id="A0A167PK15"/>
    <dbReference type="OrthoDB" id="2203211at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="360" mass="39997" checksum="790416CEE4E501E6" modified="2016-07-06" version="1">MGSFLQRGTFPPISLDTFCLPRMQGGLGIIDPKTQQSALQLRWLQPIIRAPWSPPGLVPRWMSGLLQASLPSLSPLFPLLFPSMRPSGWRDLTSPLHLAFAAIDHLPHNFDNVVVNSTTCLALPLSAVTIVPASQARFPPSWQDLLVSHLYTFDPALASLRSISITSSHPRSHVINKFLGRVQLNTLTLHLIIVCACCSPRELTEQYLSLLVQDGTSIDLFPFFNALVPSQTWTRLSTRTFRRLCSHHLVRARYFDPLVALVIGGNFGLSPFPWWLVTFGFVVYTTRFLAEPVFTLCFLSPFSLLPALFALSPPTPKTTSSSLVLPKTRCGSACGWNSLAQYLPQPHYTTLFTSSLFPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PLS3</accession>
    <name>A0A167PLS3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_140281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296219.1">
        <property type="nucleotide sequence ID" value="XM_018430376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PLS3"/>
    <dbReference type="GeneID" id="28991282"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_140281"/>
    <dbReference type="InParanoid" id="A0A167PLS3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="75" mass="7696" checksum="219CD84C8005C5D9" modified="2016-07-06" version="1">MSISKFNPGPGSPLASYFEYMNGWSGPSTSVPMTKIVPGPSQLSPAAYDGGGMSILKMILGVVFINTLLAAVSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PWD7</accession>
    <name>A0A167PWD7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF1308 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_185288</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0415 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296694.1">
        <property type="nucleotide sequence ID" value="XM_018439055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PWD7"/>
    <dbReference type="GeneID" id="28999961"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_185288"/>
    <dbReference type="InParanoid" id="A0A167PWD7"/>
    <dbReference type="OrthoDB" id="441890at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010733">
        <property type="entry name" value="DUF1308"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041076">
        <property type="entry name" value="DUF5614"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379">
        <property type="entry name" value="UNCHARACTERIZED DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379:SF0">
        <property type="entry name" value="UPF0415 PROTEIN C7ORF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07000">
        <property type="entry name" value="DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18474">
        <property type="entry name" value="DUF5614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5614" evidence="4">
        <location>
            <begin position="31"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1308" evidence="3">
        <location>
            <begin position="295"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD78654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="56522" checksum="5024EEB6A110AB45" modified="2016-07-06" version="1">MRKKSVDSDDEGGTGGTGGEVQDQILSAELIPQVQGLLERCLFIQENCKELEEHSLPGLHRLTKSLASEIQFLERLLDNPTRIKKKYIQTTNLTYIEAVYEALISSGGVVEVLRTVAVPVNDNMWRSRAEMIRHRSIKIDIVAESELVWIKVFAQNARAMRYEMAGLEQLSEDEDEDSDFGFDSNGRNDGDNEDEDGFVYQSREDDINQLPIFKKARDFLASAEAHHVHFRRPAVVFAFMRIRRDDDAFVGEMMTRLEKLGVIVHMLGDSSDSIEKTYSGVVKDVDPFDLTTPVLNIDVGTALALLSEMAHHACSPDEVQGEPLQIQAAREAVVPVLPQLRQVLEHKRLCMVQTAFDRLKNIVDVIGGPLEQARFRYLLRAHFGNQKTDRDGKSGNGVEVFDPDLWTSVPPLSITVVPDAPSEAFNQLLEPPARRAKLNNGRKIRTQFSSFHANVFGSGDTYRWTTVTSIQWMASALAEAGMTGVSIICHEPRSLAEQKMKPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PZ10</accession>
    <name>A0A167PZ10_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_163889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296838.1">
        <property type="nucleotide sequence ID" value="XM_018434889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PZ10"/>
    <dbReference type="STRING" id="763407.A0A167PZ10"/>
    <dbReference type="GeneID" id="28995795"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_163889"/>
    <dbReference type="InParanoid" id="A0A167PZ10"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053043">
        <property type="entry name" value="Ras-cAMP_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014:SF1">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD78798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="243" mass="27967" checksum="A0C40F1121A9DEFB" modified="2016-07-06" version="1">MNVSEPILSLSMPTLEKFPSLGGEDMTKMWQMFSKCKQQIEHGRRLENMCWRLWHHSVGLPADQQARSPPNIQRFISTLSPVSDGWHESFSPTPMTTPHSECSRTTTPVLDEDEEEEEEDSCDEDLDDESESDWDDDEFIIPIKRIENCFIKTQPPRPVVRRSLLSAALCDQKLCDQKENRTPFTLKHSKIASAVLTPIHPQTTSFLRHPAESIRHLISEQIQDNHSSFTSRPGMGWLENFHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PZA8</accession>
    <name>A0A167PZA8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_62435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296846.1">
        <property type="nucleotide sequence ID" value="XM_018440971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PZA8"/>
    <dbReference type="GeneID" id="29001877"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_62435"/>
    <dbReference type="InParanoid" id="A0A167PZA8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="133" mass="15306" checksum="81CFB838248FE7D0" modified="2016-07-06" version="1">MSNRATIIAPSPLRFLRAYGGYENPPHLSASLRNVSCREKYPDSQVPTGPIIPEHTQKEMDPILDHTDYSFAVFELRAIVGSTPYTLYEPINRRNHFDVSREILLFPAPSREMKWIDYDVRSTPQLTDKQLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q0Z1</accession>
    <name>A0A167Q0Z1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_62363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296916.1">
        <property type="nucleotide sequence ID" value="XM_018440958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q0Z1"/>
    <dbReference type="GeneID" id="29001864"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_62363"/>
    <dbReference type="InParanoid" id="A0A167Q0Z1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="102" mass="11674" checksum="C2452D9865DE4693" modified="2016-07-06" version="1">MANGCLISAQPATFYDHNGGFEKANDRATEDPDYYAALFTHHHFKADFSERYQNQTPPCHSELNEPLDKSREQKFGTKCEFAHQIKCTLLTNLLCYRDIGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q5L9</accession>
    <name>A0A167Q5L9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Glycoside hydrolase family 28 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_139140</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297147.1">
        <property type="nucleotide sequence ID" value="XM_018430168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q5L9"/>
    <dbReference type="STRING" id="763407.A0A167Q5L9"/>
    <dbReference type="GeneID" id="28991074"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139140"/>
    <dbReference type="InParanoid" id="A0A167Q5L9"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF12">
        <property type="entry name" value="EXO-POLYGALACTURONASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD79107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="247" mass="26908" checksum="F19914CA91103CAA" modified="2016-07-06" version="1">MDANSWYIDSCNHLMQLSKSFWKYNPALLTNLASLSLLSKIPEAGCTCVVGHSGNNNKVAPIIKTFQDCNNGGTVVFPAGQAYNVKSALELQGLKKIVKGKGYMYFNGDNIHFSGRGIINRNGQGWFDAQNNQGPTIIRVNVRNSYFAGFTVKHAPNDHFSIVGSQNNILVSVFFHIVPTYTNIPAKYTYVFGIYNSGNFIARSSTIVNGDDCFSVHSDLSNITVFELSCASGYGFSIGSLGNDAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q9Y0</accession>
    <name>A0A167Q9Y0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_162418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297384.1">
        <property type="nucleotide sequence ID" value="XM_018434615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q9Y0"/>
    <dbReference type="STRING" id="763407.A0A167Q9Y0"/>
    <dbReference type="GeneID" id="28995521"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162418"/>
    <dbReference type="InParanoid" id="A0A167Q9Y0"/>
    <dbReference type="OrthoDB" id="411871at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="304"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="955" mass="106381" checksum="EF19BF564F438FBB" modified="2016-07-06" version="1">MGIGHFFVVNVTGSVPSSASLPASQSTADVGTATSTWATKTSLILPAKTPRVSSAGWVAASQRLFSDKTGPDGFEYVYIPRSRRIMHSEVHRSLRTLGADTGRLLDINFPACEVIGILVHVQYLEEFKSQLASAKVSLVNNFDPLDPKNVADPKFANLSVSGLETQALVLQNARCLQALKFLRSHLVLLVAHFFVQSGWIGLEEIPARPVGLWNANGLQPRAIKDMLNHYQSLHMLFITETWLLSPARLPTSWSQFHLYGSPVAGNYRRSMGVSLLVSPSCSYAVTQIPMPNNYALAVKIGTLRLICLYLPPSMPTHEALDILSAIPLTDDIIICGDFNARLGSVTGDYASNPRGVALEQWLEERSLTVFNGVLSPCTPTYISFCNEVEISSIIDLFITNTNFANPSLHIATELSLGSDHRLLSLSFTYNLQHSPPAPPPMRQTWNLSHLHEDDVRSLYVTTIATKSISLLVSLQDLVQNLPTICPLIDALTNSFNTLIYDSLSSSIGSRPPCLSHWKSFWTPALQAAADHRDGCYKQWRRACGIDKINWWSRHQHAHKEFCQQVQTAKHLSWHAFCHSMNLDFNKAMSKIKQSKWRRQPQHTFQHDDSPAVAATVMCDHLALVYSGHILPDIRPPPPPLNTSLMPFASVDSPFTSPVVETFMQFMPNRNVPALATMATLNAVGACQSGFSLLFSSHLYRIFIRPKFEYGLTILPLRRTDTIQLEKIQDKCLRMIIGRHRISSTTVLKHICHLPSMSFRADVLITKFCIRAHYLPSGCLLSLLHHHHSQSSSLVTLRHNTLLQSIPIDLNFKTDQLQLSSNQVLFLVCRPLLEVDPILFLPATRVERSCLVCWRMGWLPGTSKNCPCGTDHTSRHHLAVCSLVPAHSLACLPIPSDQNCNPIDVAITALPYSSQAPCPSYWVALLTILWHFDKLCNPDGDYTHETHFCTLWAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QCS2</accession>
    <name>A0A167QCS2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_58544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297536.1">
        <property type="nucleotide sequence ID" value="XM_018440347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QCS2"/>
    <dbReference type="STRING" id="763407.A0A167QCS2"/>
    <dbReference type="GeneID" id="29001253"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_58544"/>
    <dbReference type="InParanoid" id="A0A167QCS2"/>
    <dbReference type="OrthoDB" id="2286411at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD79496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="215" mass="25279" checksum="320C43147386E3AB" modified="2016-07-06" version="1">MNQFLYKDKEIPVAVLDMEVDNEQYLLHNITNLKQYMELKPSEKQVKKKTLKSNKKEPVVKASYQSYKKEDKEKFFYWVYEKQFNVCAACKMVNIPPSTGQNWFKKGVESLMNNEDLSQRKSGSSLNSSSAGRPPKLCEEYKDFVVGIVDEKPDIVLEKMIEKLNGQFIGLKIKKTALHDFLTKKFQLTLKRAYFYSIQQNSIENIEERHKWVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QD63</accession>
    <name>A0A167QD63_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_139551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297557.1">
        <property type="nucleotide sequence ID" value="XM_018430246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QD63"/>
    <dbReference type="STRING" id="763407.A0A167QD63"/>
    <dbReference type="GeneID" id="28991152"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139551"/>
    <dbReference type="InParanoid" id="A0A167QD63"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016034">
        <property type="term" value="F:maleylacetoacetate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673:SF4">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="233" mass="26232" checksum="08B4F23D598AD9AA" modified="2016-07-06" version="1">MQSIKLYDLALNDFEKKCGSPNTLKARISLNIKGIPFDTVWVQLGEIPTVIPKLTKTTETPTVPIIVDTSKNLVIQDSWKIAQYLEATYPDAPSLFHGNEALYKAAQESIDMLSMPFSCLVIVNIANRIGDEAVKNEFRKTREAMFGTTLENFAGNPEDKIKLANEVLKDIRAKLAKSVYLSGSKVGWTDVVWLSYLVMVDVLNHDVFQARILDGVPGDNTLREWYERMAKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QKH8</accession>
    <name>A0A167QKH8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histidine kinase/HSP90-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_130229</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297880.1">
        <property type="nucleotide sequence ID" value="XM_018429346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QKH8"/>
    <dbReference type="FunCoup" id="A0A167QKH8">
        <property type="interactions" value="573"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QKH8"/>
    <dbReference type="GeneID" id="28990252"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_130229"/>
    <dbReference type="InParanoid" id="A0A167QKH8"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000001">
        <property type="entry name" value="Heat shock protein HSP 90-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="9">
        <location>
            <begin position="27"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="672"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="672"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="100"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="120"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD79840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="704" mass="80494" checksum="742E9677586DC535" modified="2016-07-06" version="1">MVETETFSFQAEISQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYQSLTDPSVLDSEKEFFIRITPDKENKVLSIRDSGIGMTKADLVNNLGTIAKSGTKAFMEALSSGADISMIGQFGVGFYSAYLVADKVQVITKHNDDEQYIWESAAGGSFTITRDEVNPSIGRGTEMRLFMKEDQLEYLEEKKIKDIVKKHSEFISYPIQLVVEKEVEKEVSDDEEMKEADSEEKPKIEEIEDEDDKKEEKKKKTIKETVTETEELNKTKPLWTRNPEEVKLEEYTQFYKALTNDWEDHLAVKHFSVEGQLEFRAILFVPKRAPFDMFETKKKRNNIKLYVRRVFIMDDCDELIPEWLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLEMFAEIAEDKENFDKFYEAFSKNLKLGIHEDTQNRAKIADLLRYSSTKSGDEMTSLKDYVTRMHEKQKNIYYITGESRASIENSPFLEGFKKKNIEVLLMTDPIDEYSTQQLKEYDGKPLVCITKEGVEIEEDEDEKKAREEEEKKCEGLCKAVKEILGDKVEKVVVSNKLTDSPCVLTTGQFGWSANMERIMKAQALRDSSMSSYMASKKTLELNPHHAIIKSLAAKVEADSGDRTVKDLTTLLYETSLLTSGFSLDDPSSFAHRIHRMVALGLSIDEEDLPTAETDDAPPAESASASAEESSKMEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R5A3</accession>
    <name>A0A167R5A3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_138431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298918.1">
        <property type="nucleotide sequence ID" value="XM_018430000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R5A3"/>
    <dbReference type="GeneID" id="28990906"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138431"/>
    <dbReference type="InParanoid" id="A0A167R5A3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026960">
        <property type="entry name" value="RVT-Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13966">
        <property type="entry name" value="zf-RVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase zinc-binding" evidence="1">
        <location>
            <begin position="30"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="101" mass="12120" checksum="28BCAEA6971A2008" modified="2016-07-06" version="1">MTQQLLLVVSLDPRQLLSIFLLCGRLRVSDAYTYDYTIGAPENHWRTFWNSSIPPNGFTIWWRLIHQKISCRQRLYDRRVKDVDSSNCIICNNPEDYWHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R813</accession>
    <name>A0A167R813_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_62118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299107.1">
        <property type="nucleotide sequence ID" value="XM_018440903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R813"/>
    <dbReference type="GeneID" id="29001809"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_62118"/>
    <dbReference type="InParanoid" id="A0A167R813"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD81067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="112" mass="12989" checksum="922EDDFB6E7B88F3" modified="2016-07-06" version="1">MSLSEHCALKINSLFFSFSLTSDVDSRILLTATHDRKFLTITRIIGEPFMDDIKKYARYLLYTLDSYFSSLSLDFFKLFERRGLLSFAGICFAHNTIRLAVWIVTLMSDISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N200</accession>
    <name>A0A162N200_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_153849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441045">
        <property type="protein sequence ID" value="OAD65044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283084.1">
        <property type="nucleotide sequence ID" value="XM_018433277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N200"/>
    <dbReference type="GeneID" id="28994183"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153849"/>
    <dbReference type="InParanoid" id="A0A162N200"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="353" mass="39806" checksum="1C5757D0C871BD0D" modified="2016-07-06" version="1">MPSNATRKSGRKGKQNARGTLSRVAAGRIEQREIAPRVSPLAAGPSGAEAPGMTVESLTQVMAAINMMYDRTVEANTGIRFLVDAHNQAIAQQALVASSVTQGVTAANVSTNRHTKGEMCAIVLNLINGRMWARNFRSNDPELVAENESRRRWNTDERIDHPDNVEVINYLRQYIVAQPRTAGFWEDMIVQKIKNNYKTCFRAVNATPEQASSKRRNNRINSHRIEIHLRRVDTYINNWLAIDTKMGYKPGNPDEMAYLHLLEKSVMSDGESEDEDVTPIIRVRVLQVARPSWRSAELNRLIQFIDFLAAENDKKIATPQSKQRMPRYLKAIAVTPVPSHLTAILPVWTIQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N3D8</accession>
    <name>A0A162N3D8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_153346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441010">
        <property type="protein sequence ID" value="OAD65444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283484.1">
        <property type="nucleotide sequence ID" value="XM_018433120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N3D8"/>
    <dbReference type="GeneID" id="28994026"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153346"/>
    <dbReference type="InParanoid" id="A0A162N3D8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="127" mass="14864" checksum="88F22992FB5A3CC0" modified="2016-07-06" version="1">MLHKKLEEYNSAFEKIMEELEEPEMPEDPKSSAPSTTDETPKKSRGQYQKPTDKDIKKLLYLYFIRGLTIKKASKIVNMKQTTAGGYILKWRKSPVVFFIKNNKEATSDEKMNLLFETYSAIKKEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NBX0</accession>
    <name>A0A162NBX0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enhancer of polycomb-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_169198</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the enhancer of polycomb family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290978.1">
        <property type="nucleotide sequence ID" value="XM_018436020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NBX0"/>
    <dbReference type="FunCoup" id="A0A162NBX0">
        <property type="interactions" value="373"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NBX0"/>
    <dbReference type="GeneID" id="28996926"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169198"/>
    <dbReference type="InParanoid" id="A0A162NBX0"/>
    <dbReference type="OrthoDB" id="435275at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024943">
        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Enhancer of polycomb-like N-terminal" evidence="9">
        <location>
            <begin position="10"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD72938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="621" mass="71101" checksum="166CB3C6101B7F82" modified="2016-07-06" version="1">MTNQMVSRFRVKKLSPKHPLPVFKESQLPDLTEAASLQRSVPQIETGVEKEEEEEHDLQAAISAAQAAVTTGAKVESYIPTPDASRVIPDEEYYSLYKKKYKEPSTLIRFSSTVEDVTGCPYMMDEQDDEFLQRYNANKANETLTPDAFEEIMWQFESVTNHQLPHLNLQLVLMIAILSYQDPSHIPEYAEFMTMIPENSKLRGRPSLETVYQHWRQRRFKRQGKSVVPELKSEDTLRSEIDPYVCFRRRETKPVRKTRRTDQQSLDRLRKLRTEMEMSRNLLEMVLRREKIRKEGLVLEHTVFDKKCKLREYQRALGIKEDEDLLPAPKKKRKTSLEIGSSGATIKIPLNKLKRDGLDGRQDKTPMQIALEAELARKREQDAPYEDFTECPYQPFPLPVPHQFFCSLPSRGPRYRKRVGRGGRIFLDRTGYKRNPSHSMGGKTKPGFQQELYDPYRFESDSSDDEFKVDEMQDSFLRHRAQLLTEVELRSLVTIPFLTPLNMMNLHAATMRANQAAAAAAAAQRAAFMANGAAANNRPNVPNGTVTAPVSSVSNLSSLPLKRQNSRTKMTPQQAAVAMANGMIAANMAAVHELILILFQAHFSSNSHVHCKDLYWNILLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NHU9</accession>
    <name>A0A162NHU9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cullin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_135478</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287844.1">
        <property type="nucleotide sequence ID" value="XM_018429722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NHU9"/>
    <dbReference type="FunCoup" id="A0A162NHU9">
        <property type="interactions" value="660"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NHU9"/>
    <dbReference type="GeneID" id="28990628"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_135478"/>
    <dbReference type="InParanoid" id="A0A162NHU9"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000050">
        <property type="entry name" value="Cullin 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="6">
        <location>
            <begin position="399"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD69804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="755" mass="86757" checksum="E89661EB9F9F5716" modified="2016-07-06" version="1">MVIDSTPLVLNSKPIKESETPGKQARSKFMSPVHTNAKLLWDSKPSVTTGEEYLKDAWNTHEALIKSILSGKTISSGMNDAYIKCEILCRDGRSAVIYSRVKNVLSRHIDGLAKNLGEMASSYDNFLQYTNKCWNQLSFDLHQLKKLFMPMDRSYIVQSTEYDSIIDLGYSLFKDNLVKNDAIKERLVANILYYVKVERDGGTVDQPLIKSLLQMLMTLSLYSTIFEPRFIEETARYYEQEGRSLIQKIDIPNYLVHVTRRVKEEGEDRKQAYLDKSTEIRLVQTVKNELVYRMTNDILSKGFDSMADEMKLESLKTLYDLLSPEKDRTELRQVFGSYIKKRGIEFIKDPSNDNAMIVTLLDRKQRADTIMEKCFDNNILFANTVKESFETFINSRNNKPAELIAKYIDSKLRMSEKKKAEVDMEKVLDDALAIFRFTQSKDIFEAFYRRFFARRLLSTFDVSEEAEMSMITKLKSECGPDFTKDLEIMFKDMSISSELQAKFREATINTDVYDKTMNVIILTSSAWPNTPKHEAILPPKLAESQEVFKQFYVSKFKGKKLTWHNALGQCILRVRFPRGVKELSTSLFQSIVLFLFNDETKETISFPEIATATGIDEKELRRVLQSLACGQSQVLTKTPPGTEVKDTDVFAYNADFSAARPRVKISPIISDTSAEENKDTENSVLFNRQCQIDAAIVRIMKAKNKLSHGALVNELFATLRFPINASDIKKRIESLIEKEFLLRDEEDNSAYIYNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NK66</accession>
    <name>A0A162NK66_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GHMP kinase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_111376</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293018.1">
        <property type="nucleotide sequence ID" value="XM_018428211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NK66"/>
    <dbReference type="STRING" id="763407.A0A162NK66"/>
    <dbReference type="GeneID" id="28989117"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_111376"/>
    <dbReference type="InParanoid" id="A0A162NK66"/>
    <dbReference type="OrthoDB" id="1924968at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047940">
        <property type="term" value="F:glucuronokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053034">
        <property type="entry name" value="Glucuronokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38710">
        <property type="entry name" value="WITH PUTATIVE URIDYL PYROPHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38710:SF1">
        <property type="entry name" value="WITH PUTATIVE URIDYL PYROPHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="3">
        <location>
            <begin position="132"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD74978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="389" mass="43310" checksum="219E1C1BCE3D7063" modified="2016-07-06" version="1">MDPNISLYDYQSIWSSYFDKNIKDKYLKDDKYNTDPIIVRSYARVGLMGNPSDGFYGKTMSLLISNFWSEVVLVPNSPIKPGFGNITFMTNMLADPRSFSNLSSLVTVCENDGYDHGDRLLLACCKVLFTHCKKNNIPIDTSQGFVVMYDTNIPRQVGLAGSSAIITAFWKALLKLYRITSIQIPIELQASLVMAVETEELGIAAGLQDRVIQAYGGLVSMDFEKDHMQTHGYGKYTILDHSTLPPLWLAYVASPEDSGKVHSTVKQRFLAGDSKIIEGMQVFATLTDKAQESLKNGDHRGFAELMTCNFENRRSIYGDAVVGEVNLRMINIARQNHCAAKFSGSGGAIVGMWNGSNIESRKQDLLSLKQSLEKEGFVYVELVPMGRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PGT2</accession>
    <name>A0A162PGT2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_145993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290717.1">
        <property type="nucleotide sequence ID" value="XM_018431576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PGT2"/>
    <dbReference type="GeneID" id="28992482"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145993"/>
    <dbReference type="InParanoid" id="A0A162PGT2"/>
    <dbReference type="OrthoDB" id="2290427at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="253" mass="28119" checksum="BA94C714C63D068C" modified="2016-07-06" version="1">MVVKTPSGDISIKVHVLMTTGNIPALGKIACHVDHMSKDGCCICHIVGQSPGHGQYFHKLSSITMHTPESFKHFDEVASSSKKGLTGQSSFFLLDSFSGPFFFALDEMHGICHGIGKQVWGLVCGMYGKDHPLSLSLAAQKEIGTATVSNRRSILTSFYSAWINIATRSEYFWAVDWADFILFVIPMLVTERVHDQAAHKTLLDLVQTCNLLMSRKLSAEKKTLIKINLIAWNTYLEALLAKEEVQLKIFTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PH94</accession>
    <name>A0A162PH94_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_78017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290857.1">
        <property type="nucleotide sequence ID" value="XM_018443325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PH94"/>
    <dbReference type="GeneID" id="29004230"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_78017"/>
    <dbReference type="InParanoid" id="A0A162PH94"/>
    <dbReference type="OrthoDB" id="2550823at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="141" mass="15369" checksum="61C7368E2D590F7C" modified="2016-07-06" version="1">MSILKNVFAIHGVFEGLLGFTVFFFPQLFASYVNLAEGQGEFIMRAFGAGILALGTGGILCNGMPDVLPCKRAIGASFLAFHGLLAFLSFQSRKNGSLTDLVGWVACGIHSVMAVLFYVWYKVTESQVKTYTKKNGPKHDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PM75</accession>
    <name>A0A162PM75_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_102850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292227.1">
        <property type="nucleotide sequence ID" value="XM_018427743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PM75"/>
    <dbReference type="STRING" id="763407.A0A162PM75"/>
    <dbReference type="GeneID" id="28988649"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_102850"/>
    <dbReference type="InParanoid" id="A0A162PM75"/>
    <dbReference type="OrthoDB" id="3044029at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="139" mass="15046" checksum="5E2320B086FD4B70" modified="2016-07-06" version="1" fragment="single">VVDASNFCVFLPPSDSVDRLISDTEWDGDAFCLGSTPEATGAETMPTDFIQSAHFVATDEYVQVTGQIDPSKANLNVSDEGGQFDVRAPIGSTCAGWTYYVNLIEPINLTYCMRCCNDTTNCNRGISEKGCAHIIPGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PW26</accession>
    <name>A0A162PW26_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_61298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292686.1">
        <property type="nucleotide sequence ID" value="XM_018440786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PW26"/>
    <dbReference type="STRING" id="763407.A0A162PW26"/>
    <dbReference type="GeneID" id="29001692"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61298"/>
    <dbReference type="InParanoid" id="A0A162PW26"/>
    <dbReference type="OrthoDB" id="206969at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018800">
        <property type="entry name" value="PRCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621:SF2">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10253">
        <property type="entry name" value="PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="410" mass="44958" checksum="ACD4F8282A573A18" modified="2016-07-06" version="1">MSLVADYGSSDSEDSDVETTLVPKKPSSFASLLPLPKKKATTTPTSSFASLLPAPKQATPEKPVFYVEVPSKHKDLEEDEESTKRSKKLKSSGATDFADLLPAPRNTSLHKSIVPVTKKTTDASLMPLALARKQKAAREKKEAQEKAEAEKLLKSIPKVNSAPEHEEDEDDTAVEHTGSFFPLGPEVSKIPAYTLPIPKKKTLNTDMADKRTTSKSEKVEPELKMETTSAAAAAMTTTTATAVDAYAYSYDPNAMYAYGTDTSAYYQQHYLEANQYGGDQSHNGVDSNTDEVDADALGRLAGKRFKGQDSGIQFKTINQADMLPTEEWRMAALASTPKFTNDGPAITATTAQKKRNNLMALAAQAVEMQEKLSEQYAENKRTKRETKNKYDLDGRDLNEEQDGRKGENEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PWN5</accession>
    <name>A0A162PWN5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphatidyl-N-methylethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="17">2.1.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Phospholipid methyltransferase</fullName>
            <shortName evidence="17">PLMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHYBLDRAFT_180191</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32739"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 17">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Endoplasmic reticulum membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Mitochondrion membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.71" evidence="17"/>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294727.1">
        <property type="nucleotide sequence ID" value="XM_018438277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PWN5"/>
    <dbReference type="FunCoup" id="A0A162PWN5">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162PWN5"/>
    <dbReference type="GeneID" id="28999183"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_180191"/>
    <dbReference type="InParanoid" id="A0A162PWN5"/>
    <dbReference type="OrthoDB" id="8300106at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000773">
        <property type="term" value="F:phosphatidyl-N-methylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000005">
        <property type="entry name" value="Phosphatidylethanolamine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03216">
        <property type="entry name" value="PLMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024960">
        <property type="entry name" value="PEMT/MFAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458:SF5">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005444">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51599">
        <property type="entry name" value="SAM_PEMT_PEM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 17" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13 17" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14 17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Lumenal" evidence="17">
        <location>
            <begin position="1"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="intramembrane region" description="Helical" evidence="17">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="17">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="17">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="17">
        <location>
            <begin position="113"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="17">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="96"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="178"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAD76687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="193" mass="21399" checksum="9622C097A00EB637" modified="2016-07-06" version="1">MDKLIDLTQPSLYLSIATIFFNPIFWNTVARAEYHKRVLTKLAGGNPYYGCYALAVTIFSLGIIRDYVYNTALASQPTHPILETTLAQGFAVVFFTVGSILVVTSMWALGVTGTYLGDYFGILMSERVTGFPFNVCENPMYVGSTLNFLATALWHASPAGIILTLLVYVVYLVALEFEGPFTTMIYANKDKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PX58</accession>
    <name>A0A162PX58_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial glycine transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Solute carrier family 25 member 38 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_181021</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>glycine(in) = glycine(out)</text>
            <dbReference type="Rhea" id="RHEA:70715"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293056.1">
        <property type="nucleotide sequence ID" value="XM_018438403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PX58"/>
    <dbReference type="FunCoup" id="A0A162PX58">
        <property type="interactions" value="216"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162PX58"/>
    <dbReference type="GeneID" id="28999309"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_181021"/>
    <dbReference type="InParanoid" id="A0A162PX58"/>
    <dbReference type="OrthoDB" id="1924968at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904983">
        <property type="term" value="P:glycine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03064">
        <property type="entry name" value="SLC25A38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030847">
        <property type="entry name" value="Hem25/SLC25A38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181:SF3">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="8"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="132"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="229"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD75016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="324" mass="36423" checksum="CFCEC02A973C5363" modified="2016-07-06" version="1">MTTTKEFRNPSVHAIGGALSGMTACVMLQPLDLIKTRLQQQRQDHLAFLREAKKKGLLIAPQNSTIYSTVRDIVSSNGFGGLWRGTIPTIIRNVPGSALYFLALSEIRQLLEKRRPSWQKYVYPKQSSTKNQTQWENLVSGATARGAVGYIMMPITVVKVRYESNFYNYRNISDAFGSIIKNDGFRGLFAGYGATFIRDAPFAGIYLFFYEQSKAWSKTFAKKKNIEIPNMAINLGSGVVAGVAATCTTQPFDMLKTRMQLKPALYKHLVQAARKVFKEEGLVGFFDGISVRLIRKPLNSAISWAIYEEVIRWNDAKLIQDNPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PXD7</accession>
    <name>A0A162PXD7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_62924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294927.1">
        <property type="nucleotide sequence ID" value="XM_018441040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PXD7"/>
    <dbReference type="GeneID" id="29001946"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_62924"/>
    <dbReference type="InParanoid" id="A0A162PXD7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="161" mass="18620" checksum="0805034095E1A04B" modified="2016-07-06" version="1">MSLSHNKRWTKLDSILQTTLGRATYKAMQKKDKFKEGKILKKASDFAKTILGKNKEDEIMHIALYSHSEPEMLNTNGSSSGQQTVAEILTGNEEDEREDERVKRYDDSSDVLFENSDDVYSEAIINRKILSLLKKQDHHLEKQAQHMEKQEAFFDKCLILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T202</accession>
    <name>A0A162T202_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_153297</name>
        <name evidence="2" type="ORF">PHYBLDRAFT_153303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441009">
        <property type="protein sequence ID" value="OAD65606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV441009">
        <property type="protein sequence ID" value="OAD65612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283646.1">
        <property type="nucleotide sequence ID" value="XM_018433108.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283652.1">
        <property type="nucleotide sequence ID" value="XM_018433109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T202"/>
    <dbReference type="GeneID" id="28994014"/>
    <dbReference type="GeneID" id="28994015"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153297"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153303"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="132" mass="14448" checksum="5C03CB0B4D35B6FD" modified="2016-07-06" version="1">MTPSSLSPHYAAQSPSGRKPDLVAKEVLEWWQTNGKHPFIQPHISSPSNVGANSPENLPLGDKVQLIRLPVASPSAVKEFSQVSSEEPAHLTTETMPHDFSELTELASNNFHFPMLVAWKNLPATVVRDASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T561</accession>
    <name>A0A162T561_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_119360</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441004">
        <property type="protein sequence ID" value="OAD66332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284372.1">
        <property type="nucleotide sequence ID" value="XM_018428680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T561"/>
    <dbReference type="FunCoup" id="A0A162T561">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162T561"/>
    <dbReference type="GeneID" id="28989586"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_119360"/>
    <dbReference type="InParanoid" id="A0A162T561"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005053">
        <property type="term" value="F:peroxisome matrix targeting signal-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059104">
        <property type="entry name" value="Beta-prop_EIPR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044536">
        <property type="entry name" value="PEX7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23609">
        <property type="entry name" value="Beta-prop_EIPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="88"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="EIPR1-like beta-propeller" evidence="12">
        <location>
            <begin position="131"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="131"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="174"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="218"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD66332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="304" mass="34277" checksum="30C707E307C50779" modified="2016-07-06" version="1" fragment="single">VQWSPFFENKLAVAASSNFGLVGNGRLYLLAVGGGPEGIMAERVYDTQDGLFDLAWSEVNENQLVTSSGDGSIKMWDVTLADFPIQNWQEHQREVFSVEWNLITKDVFSSGSWDHTVKIWNPQAPRSLQTYTEHTHCVYSTAWSPYNPSMLASASGDQTVKIWDTKSPRSIQTIHAHNNEILSVDWNKYQDNTFVTGSVDCTIKVWDMRRPDRELICLPGHEYAVRRVKCSPHRPNVVASAAYDMSVRFWDTAAPVGNNLMGVHDPHTEFVLGVDFNLYVEGQVASCAWDESVHVFVPPALLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T8U4</accession>
    <name>A0A162T8U4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_70291</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD66932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284972.1">
        <property type="nucleotide sequence ID" value="XM_018442253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T8U4"/>
    <dbReference type="STRING" id="763407.A0A162T8U4"/>
    <dbReference type="GeneID" id="29003159"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70291"/>
    <dbReference type="InParanoid" id="A0A162T8U4"/>
    <dbReference type="OrthoDB" id="413582at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="270"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD66932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="353" mass="40516" checksum="AFF5721ED116D274" modified="2016-07-06" version="1">MGSFATLKKEQLDDQVVAVKTYTRYHGHLVRRHCERELRAVEHLGLRSPESLKMKNRGLRIVDNDDNDDNENEKTRKIKNKRGFDYQMKLLLMHVIDVVTTDQIISLTMPFYEHTLASVSLSLTEARRAVYQMAKALSYIHAQGMVHCDVSPSNVLVNSAGQCALSDFGCAHLQKFMPDPREVDEIGTRYYKAPEHLFGYRVYRPSTDIWSLGTLFCQLLLGFPLFAGENDLEQIGSIVRRLGSPNESEREEMNCCPDATKLFFFMPPSECDSEDDSETELSEDQEEEEEEEEEEDALSECSDIITLDAAMENYSIEERDRVILRKMLTWSMKTRGSVEEILDINVSENDWVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TBG5</accession>
    <name>A0A162TBG5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dynamin GTPase</fullName>
            <ecNumber evidence="3">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PHYBLDRAFT_128221</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="3"/>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285392.1">
        <property type="nucleotide sequence ID" value="XM_018429210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TBG5"/>
    <dbReference type="FunCoup" id="A0A162TBG5">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TBG5"/>
    <dbReference type="GeneID" id="28990116"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_128221"/>
    <dbReference type="InParanoid" id="A0A162TBG5"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000741">
        <property type="entry name" value="Putative mitochondrial dynamin GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="Dynamin"/>
    </dbReference>
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        <property type="entry name" value="Dynamin_GTPase"/>
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    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
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        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056495">
        <property type="entry name" value="LIS_MGM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24550">
        <property type="entry name" value="LIS_MGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="19">
        <location>
            <begin position="22"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="18">
        <location>
            <begin position="588"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022792"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OAD67352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="688" mass="79135" checksum="3D3EF81DC05626DC" modified="2016-07-06" version="1">MMLTKKLIEIRTILMSIDHNETLKLPSIVVIGSQSSGKSSVLEAIVGHEFLPKGTNMVTRRPIELTLIHTPNQEEEYGEFPQLGLGKMHDFKKIQKTLVDMNMAVPDSECVSDKPIELRVYSPNVPDLTLIDLPGYIQISNANQPESLKSNIEALCEKYIRTPNIILAVCAANVDLANSPALRASRKADPLGLRTIGVITKMDLVSPEQGVSILRNADYPLRLGYIGVVCKAPERVQGNMTKALIRNETSFFREHLMYNQRDIQVGTSTLRFKLMSVLEQSMGKSLYSIVDAVQRELEEARYQFKVQYNDRRVTAESYVAETMDSLKHNFKDFANNFGKPQVRHEVRTMLEERVLDICAEQYWEDPKIADLAKSSPDDLYWLYKIDLAAAALTKSGIGRSTTQLVVDVLLSNMERLAKAEPFSFHPETRKQIMNFTSEILRTKFLTTSDQVENTIKPYKYEACICETEWAEGVKRSIGLLEKELKMCDEMSLAIKNSVGKKKLKSAINYLLDNEREDTRRQSEIRRMEEDGMASHEELFAPGDDEDTVKSFYNPRLIEKAKEALFLRDRAMILKYRIAALKSRQCKSPDNKQQCPEAFLNVIAEKLTYTAVMFIQVELLNEFFFQFPREVDNRLVYEMNRKQIQQFARENPPIQKHLQLQERKIKLEEVMDKLNYLVKRQADRQNRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TCU2</accession>
    <name>A0A162TCU2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate-binding module family 21 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_79674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441006">
        <property type="protein sequence ID" value="OAD66103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284143.1">
        <property type="nucleotide sequence ID" value="XM_018443489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TCU2"/>
    <dbReference type="STRING" id="763407.A0A162TCU2"/>
    <dbReference type="GeneID" id="29004394"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_79674"/>
    <dbReference type="InParanoid" id="A0A162TCU2"/>
    <dbReference type="OrthoDB" id="1881at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF36">
        <property type="entry name" value="GLYCOGEN-BINDING SUBUNIT 76A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="2">
        <location>
            <begin position="144"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD66103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="506" mass="56342" checksum="06A929FDD8AB732A" modified="2016-07-06" version="1">MMSFSTFPRHESFGPSTWSRSVVLNKKPSIFAHEEREPSHLPAPQQQPAAKKNISNPSNQKPLHINLSQLTTSPSLKSSLRSHSAPTTPTGSKTVKFNPVHLERICLFRKTQTPSALLQDNQGRRHPEDPPSFRVGYLNFPPRETTDRSKNILVEKKFIVEDNAVKGRVQVRNLAYHKSVSIRYTFDCWQTSHDIDAVYKDSQNTQSIYDTFCFTIPLVNLADRGQVRATIDFAIRYHVNGQEFWDNNDGKNYGIQILADPIESTYHSQTYGRVTDVDNPDNHNHNHKNDDDDDVDDDDDLKIDTPQRPNHKGLGNRYSFGLSLSQAKKVVSPASETIPPVPSVPIKPSVRVTKEAKPTMLVQPRPKKPEMSGLTTSAIISGDNNSRNNNNINSNIGLSARPTNSSNSPSNSTSQSPSPSTYAHISPAKSPVVSSPIPINGASAVRHNLFESYYHSAPSSPTFACQPRHAYIQSTPDLDSESYLDLVNKYCFYGTNSAHTPMPINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TIT8</accession>
    <name>A0A162TIT8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_39809</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286972.1">
        <property type="nucleotide sequence ID" value="XM_018440134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TIT8"/>
    <dbReference type="FunCoup" id="A0A162TIT8">
        <property type="interactions" value="691"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TIT8"/>
    <dbReference type="GeneID" id="29001040"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_39809"/>
    <dbReference type="InParanoid" id="A0A162TIT8"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000001">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="7">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD68932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="136" mass="15355" checksum="0786D0DBBE68EE07" modified="2016-07-06" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAIGALQEASEAYLVSLFEDTNLAAIHAKRVTIQPKDIQLARRLRGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TRQ3</accession>
    <name>A0A162TRQ3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_148446</name>
        <name evidence="1" type="ORF">PHYBLDRAFT_153781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441016">
        <property type="protein sequence ID" value="OAD65121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283161.1">
        <property type="nucleotide sequence ID" value="XM_018433254.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288572.1">
        <property type="nucleotide sequence ID" value="XM_018432089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TRQ3"/>
    <dbReference type="GeneID" id="28992995"/>
    <dbReference type="GeneID" id="28994160"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148446"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153781"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="40202" checksum="670E44BE4D966CE3" modified="2016-07-06" version="1">MTKRIPTAPRRPNLRMNAVLNSTIAGVVAPIDTPTPEVAVDTAPEVQVAVTPMDHVLTLLAANNVSMQSLQENAKGVTDAITHLKNGLDLSNKTNEFLKNSVLQLMTENAEIKKAVTSQNSVMPSAVPADSFSSMDDDLDLGAKHYPLISQLINSYIKKPNFVSTDPLKVAENNNRSAWSMTGTYGNKYNKTLALALFKYLRPQRCCTNVSKSVIMNIIKNHYQNQVRVFRTSAEKIMARNKAGRRRNRKKTLLDRCIITYQTYTEAIHEGMNRYDCGNILSIDVMSDGESDGDNKVRAYRPSWRTDELQTFISTIDELTVIRLKKNSESLKKRIPYEKEVSIPENLAVTLPDWCFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TSP3</accession>
    <name>A0A162TSP3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_66296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287523.1">
        <property type="nucleotide sequence ID" value="XM_018441622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TSP3"/>
    <dbReference type="GeneID" id="29002528"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_66296"/>
    <dbReference type="InParanoid" id="A0A162TSP3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="472"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="507" mass="56615" checksum="89B3F0EBF2C4CF8D" modified="2016-07-06" version="1">MPNITASEKFNYTQTINRNTVGLNLEYLKQTKTIICILKPTNFKAVTLILLAFIPKCYAPPIEQDDVKFTSKLPVVSILRTVLLGYMTHIVTIRPRTGVSGFSTIFRRLLALLYPSSGIGTAIESMYKSFNGDKILGISQYTFLLKSYDDENSDKATEKKDGDSHYPNNKASSDSLLLIKASASECEKDEEENTESTDAQELHLEISRLRDRLVQDAKNKNIDIKEYDNAPYLAAFLHVIGPEQAKKTKGCILNRSVTIGFNNVKPTIYMLSSRVTNEISVTGPGAACKNQAEILPKVFRYMSDSMIDQLETAHNMDETSYVEILVTIGQLFFTTIECMDIDGDRWAKVIIIIYTSMSVLQTGSLIALHKQTMAFSIKNDGRENMFLNSKVLTLTEEERKLLGESTNKFESNEEVVILSTFTGIVVFLLIGIWADYSSHSITEWLVLAWILSPILAALGFFTFICNNSDIMLYLILVIASISSIGCLIAATIIGYLPKENIIISPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TU00</accession>
    <name>A0A162TU00_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_70538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287853.1">
        <property type="nucleotide sequence ID" value="XM_018442294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TU00"/>
    <dbReference type="GeneID" id="29003200"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70538"/>
    <dbReference type="InParanoid" id="A0A162TU00"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007839946" evidence="1">
        <location>
            <begin position="19"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="137" mass="15875" checksum="B878B633C55158FA" modified="2016-07-06" version="1">MNLSSLLFFSFLLLGVSTRSLIYIKKFIYTLEKSPSVVQRPCPHCPYTEHPKIGYKRIVAQEQNFRYVAVTVTVAFQTQSPIKHLHRQAEVENSVAKKKNETKTNVQMLVNILKTDFRSRTKLNIFIIAIIYKQEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TZL5</accession>
    <name>A0A162TZL5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_170510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289163.1">
        <property type="nucleotide sequence ID" value="XM_018436364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TZL5"/>
    <dbReference type="STRING" id="763407.A0A162TZL5"/>
    <dbReference type="GeneID" id="28997270"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170510"/>
    <dbReference type="InParanoid" id="A0A162TZL5"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="681"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1122" mass="125909" checksum="4E5D3020E1187FF5" modified="2016-07-06" version="1">MSLREISDRRTHLTNGIHVLRVIFHSGLERYKERARSVEQKRSVAMVHHLVKDARKTIYSVIMTTPEKDTSNQSIYTNPINSPLQYQRTPVGFSSLLYESIHISSDTRLPPLFCDFFHLSVQPSTIWKSLVHIFQKKSQKSQKTQNSDRSHQEELRAIITESLGLFSVHNILYSSFIDMAHLQNVMSSVVANPLDKYKSATEWLLIDIIVALTLQAAHRTLLSVCSDVAPDIHHCSQSFYSQANRQFWRLTYPTIPEREPNMVLSQNLVRAAILISHYQCTSISEDQALVTLRTGVGFAQICKLSSYSEMTMMPMMPKAAILDTEEQQRLCILYKTLIGWDTWFRFYLYQPNPGYQDNTVDHCLKLFDSNFYYTQGNQQRVIHIIEIYTSFIKSLLRSRTSPIGVQTIKDQFDWLERASLINLSNTRSPQNKYQYPTELTSCSASVISLYHQILILQVTSSFWSLPYSQSSLDNNQILVKICTSDAAIAVDVDTDVDTDADADANTEDEAEIETEAAVSDNELSFYECGASMCIEASIKVIQIANESISRNTTAAAIMSDVHHPTLLHALCWAVSGMISSIQNGSHHSPRLSPILNTSTLTRTRKDDQSCTKFSTSLSKLKALLEHLESVAPSQNQWKNLVELLNTAAADIPNTPPTNLTGSLTPDSQDFKDNTLPSISISISSRNSSSSSSSSGSGSGSTACSFPITEPTDKTKTKNSRVKKKRPFTYLTNNNTIGSDQNIQKEIRQRVRVRSKSGPIKIDYAQSPFLPPSAKESLVTERDSQHSHIMGNEDQWVPAPFTTSLQTYPALKSPKANTRPRVKRTRSCSDSYSSLDMDGLNKLSLALDMCSTVGTRCKLSTLPGERIATNTKTFQKHVWSGLEPNIPTCPPPILNYLNYQNSGYHKEQPSEMINVNKGLDKDFFNESTGMIETLHQPNVPASLSISTTPNQSVHNGSVFGYLSDMSPILSTGNLPCERQPTTLFEETQPSKEEKTFLWAYNNSNNSDNIRSVQQNSYQGTEDRSVKVDELRRDGSCDLFYTSVTPQITPCSLFSSPLPWTNPPAYSFQRAGFGQSRSNPMKSTAVGLFEHSTEYVSSSSTSPQETTWETTSKEFLLYPWDSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U034</accession>
    <name>A0A162U034_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_169533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290442.1">
        <property type="nucleotide sequence ID" value="XM_018436094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U034"/>
    <dbReference type="GeneID" id="28997000"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169533"/>
    <dbReference type="InParanoid" id="A0A162U034"/>
    <dbReference type="OrthoDB" id="2267841at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD72402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="250" mass="28981" checksum="D225FB5B692B2DCD" modified="2016-07-06" version="1">MFAIANPNEVCCKCTRCNRNSLGYTMTDKKTAKRHAQNDNNRKIDKTINVLTAEVNTGETDMDIDQIEEYVEDNNHSIGAPSPEQYVHTYLPLLVEESLFGTEEYTSEYESEYELSDEIEPEEQDREEEQTNLPENFWHRVIAIFTVMFILTFIVDDSAVILITFINTILAHYREDFQLFISIPGLKKMTGYNDLMNEVSNYVACSDYHTLYDYRNTTQTCCNFRRVSSKTFCGNDLYKHINVTLVSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U062</accession>
    <name>A0A162U062_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_146613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290462.1">
        <property type="nucleotide sequence ID" value="XM_018431686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U062"/>
    <dbReference type="GeneID" id="28992592"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146613"/>
    <dbReference type="InParanoid" id="A0A162U062"/>
    <dbReference type="OrthoDB" id="2431110at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="275" mass="31889" checksum="5D6B233DC5183ADB" modified="2016-07-06" version="1">MQELANGIVVPCGYARITKKIADGFSFMKADKWKSWCVIYSPFVLKHVLPAKNLENWILFVDACCLLTKPLINDKEIDEAHSKLQLFCIRFQTLYRKLAMTPNIHLHLHLGKCVHDFGPIYAFWLFSFKRYNGLLKNIKTNQKGSFESMMMKRFLERTYIGSFIQSFVNHLPQFAIDFLHRISNSQDQLAALHPSSTASTFSLSDFVEYLLNPCHSALGCEPLPPSVFPIKLDQRITMCKGHYECLLEFYRHAYDSHDLFVHYSNCESNQIFVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U3N6</accession>
    <name>A0A162U3N6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_79218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290143.1">
        <property type="nucleotide sequence ID" value="XM_018443442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U3N6"/>
    <dbReference type="GeneID" id="29004347"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_79218"/>
    <dbReference type="InParanoid" id="A0A162U3N6"/>
    <dbReference type="OrthoDB" id="2240906at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007840031" description="Phosphatidylglycerol/phosphatidylinositol transfer protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="16405" checksum="F3A97EA85BF3C353" modified="2016-07-06" version="1">MFALRSSFFLLSAIVLVAFIQTACASVFSQLQYIKIVSPTSGQDVKAGESLVVKYVMQPLVLDGVSSGKALSLNISLHSRTGNQKQQKLAIVHNSCPVTAQTNKYVTHTKTWSVPANLKPGSYAIDFEELVQFRRSQVTATETVKINIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U4Q8</accession>
    <name>A0A162U4Q8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_65638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290353.1">
        <property type="nucleotide sequence ID" value="XM_018441501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U4Q8"/>
    <dbReference type="GeneID" id="29002407"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65638"/>
    <dbReference type="InParanoid" id="A0A162U4Q8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="122" mass="13620" checksum="1623C96C5FD3F0AC" modified="2016-07-06" version="1">MTCQENSNLTETTFLSNRTNQSGLHVRGPVSFSNPSGKNASSAEDHKELLSLECNAILLNILLFIGLLTRIMYFSLFCLLIFPECNTANWNQIKQFHAGKKVAIYGPVEPKCCPHNQKMSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U6W5</accession>
    <name>A0A162U6W5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_64894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291982.1">
        <property type="nucleotide sequence ID" value="XM_018441365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U6W5"/>
    <dbReference type="GeneID" id="29002271"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64894"/>
    <dbReference type="InParanoid" id="A0A162U6W5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="155" mass="17900" checksum="A6AE70AEC1D8DA3A" modified="2016-07-06" version="1">MSEEETKVIVFEYIHAQPQAVSFWSGMVVSIIHTHCQDIYTRYWSVVDKKMGLMVEEDSEMAFFGAIQKGAMLDSKSDTERLFSGFPVHMLKVAYPSWRSNKFNKFLSLIDESMQSDHKAKGNAKLRMSRFLREEKNVAVPRWLILSLSPCAIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U9L8</accession>
    <name>A0A162U9L8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_181266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292642.1">
        <property type="nucleotide sequence ID" value="XM_018438440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U9L8"/>
    <dbReference type="GeneID" id="28999346"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_181266"/>
    <dbReference type="InParanoid" id="A0A162U9L8"/>
    <dbReference type="OrthoDB" id="2279327at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="209" mass="23885" checksum="B27B40D79CFA36EB" modified="2016-07-06" version="1">MIDIPSSYIVSSKLSPLEPQDVLRVLRLVQSEWNDECVKDRMNRHPTPLIAVGIANPHDLQRVVRVGVPVIHLDRECRALKAAQARYLRELKYGQILASVGSAVLSGVLVARGLKQMNGRSLRALLSKKSWFWMYFGGAGLIWIGQVSLMRALKESYGLVTLQDECFMVRRDLVVNKWRSVLQRWLPYCLLVGSVFRWTRVYSKKGVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UB76</accession>
    <name>A0A162UB76_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_13358</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292972.1">
        <property type="nucleotide sequence ID" value="XM_018429581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UB76"/>
    <dbReference type="STRING" id="763407.A0A162UB76"/>
    <dbReference type="GeneID" id="28990487"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_13358"/>
    <dbReference type="InParanoid" id="A0A162UB76"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07722">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000041">
        <property type="entry name" value="Metallo-beta-lactamase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047921">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF0">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="33"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD74932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="245" mass="27659" checksum="A00ACC76052AF5EE" modified="2016-07-06" version="1" fragment="single">LMSRLPPLPEFARLSDRVWRVMGLNPGRWTLQGTNTYLVGRGARKVLIDCGAGRPEYLPLLIQSLKTISEDCFISDIYLSHCHSDHWGGVEQILTSPLSKPNVHKFPLPPGGKDETSFMGSFPWSLVKLTPLEDNQIIKVDPNTTLHVLHTPGHANDHCAFWFEEEQSIFTADCILGHGSVIFSDLSEYMASLKKMEALVPKRLYPGHGTMIENGPAKIKEYINVRKQREDQIVRIMHSDTKKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UGP5</accession>
    <name>A0A162UGP5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_186634</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293113.1">
        <property type="nucleotide sequence ID" value="XM_018439265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UGP5"/>
    <dbReference type="STRING" id="763407.A0A162UGP5"/>
    <dbReference type="GeneID" id="29000171"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_186634"/>
    <dbReference type="InParanoid" id="A0A162UGP5"/>
    <dbReference type="OrthoDB" id="15082at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="290"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="308"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD75073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="538" mass="63141" checksum="A71FBAF48B461813" modified="2016-07-06" version="1">MYQDTFEEDDLVAEVELVAQARYSQQSDVEDNFDEDSTQQQPSAVQIPDGVRNFIMHFYRNVLDSNVYELHNIYDSSFNKLTDKYYTKQAWPEAEVIAPLVNDDQVFLTLYRELYYRHIYARLTPTLEHRVHSYENYCDLFNYILNSEGPVNLELPNQWLWDIIDEFIYQFQSFSNYRDRLKNKTEQEITLLRTSPQIWSCYSVLNVLYSFIQKSRINEQLLVSKNGGDMMEAAGEYGSRPLYKMLGYFSIVGLLRVHCLLGDYMLALKMMDNIVLNKKAMFARVTACHVTTYYYVGFAYMMMRRYADAIKAFSTVLAFIQRTKQYHARSYQFDQIAKKGDQMYALLAICIALCPTRLDENIHSQLREKYGEQLFKMQKGEESLPIYEDLWQYACPKFIAATGVNLTKTENDQLNDPHANQLKIFMSDIRNQIMLPTLRSFMKLYTTMGIDKLAKFLEVDAEELKVHLLILKQKSRQFKSVTGNLLEGEYMPTSDLDFCLKQDVVHIAESKVGRRYADWFLRNINRFEDIVAALEQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UJJ9</accession>
    <name>A0A162UJJ9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Piwi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_85795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293783.1">
        <property type="nucleotide sequence ID" value="XM_018443619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UJJ9"/>
    <dbReference type="FunCoup" id="A0A162UJJ9">
        <property type="interactions" value="274"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UJJ9"/>
    <dbReference type="GeneID" id="29004524"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_85795"/>
    <dbReference type="InParanoid" id="A0A162UJJ9"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="2">
        <location>
            <begin position="218"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="3">
        <location>
            <begin position="503"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD75743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="840" mass="94549" checksum="6562228F9C365B56" modified="2016-07-06" version="1">MVQEITTLTLRPSEGKAGRPIKVRANFFEVTSLPNQNIHHYDVRIDPILKNDKVNRKIWEALEVLEADNIFKGIKIIYDGRANAFAPKALPLGPTSLKTFEVNLGDSRNPEKSTFRVAIKHVNEINLEELARFLRGEGASTNNVLTSVMVLDVLIRHMPASLVDYTAFGRSFFIPQDKRPLPNGVETWQGYYQSARPTPGKMMLNVDVSASVFYQPGPLPDLIVKILGKRSLDELRGGLRDRDIKIIERTIKGLRLKVTHRGEQRRDYGIQRLTITPADKTMFTTEDGQEYTVAGFFQKQYNKRLAFPFLPCVVVRKDVFLPMEVCNILPGQRFRQKLNEAQTAEMIKFTCTKPHIRANKIKQGIQLLQYQANPYLQAFSVKVKPEMAIIKARVLPPPTISYHPASQEPVFAPQGGVWSLRGKKACTAASLTSWSIVNFTHQMPITVIQRFVRELCQTFSDIGMNVINRTPDIISADPQGNIERTLKEAWLKAGNQAKAQPQLIFCVMPHRGTPLYAEVKRVSDTVIGVPSQCLQSKHVSEAKKQLCANVALKVNMKLGGQNVKLAPNQIPFIAQRPTIVFGADVSHPAPGDFSRPSIAALVASMDVNAVRYASSIRIQANRTEVIADLGNMVKDMLKVFYHTCGQKPERILFYRDGISEGQFSESMNNEVNAIKAACLALDPTYNPTLTFIIVQKRHHARFFPIDQRDTEKSGNCLPGTVVDTDVVHPFEFDFYLQSHSGLQGTSRPTHYHVLKDENNFTPDALAELSYRMCYTYGRCTRAISMVTAPYYAHLLAARARFHRRNENWSDGATTESMDSEGQIASFSAVKPDLQKVMYYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UY51</accession>
    <name>A0A162UY51_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Type IB hybrid histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">HK_IB</name>
        <name evidence="7" type="ORF">PHYBLDRAFT_185328</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296783.1">
        <property type="nucleotide sequence ID" value="XM_018439060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UY51"/>
    <dbReference type="STRING" id="763407.A0A162UY51"/>
    <dbReference type="GeneID" id="28999966"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_185328"/>
    <dbReference type="InParanoid" id="A0A162UY51"/>
    <dbReference type="OrthoDB" id="10266508at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="275"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="791"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="71"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="604"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="605"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD78743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="930" mass="102904" checksum="8F89677686145062" modified="2016-07-06" version="1">MDLQARELHTDTIDNRNHSLSTANPSLLLQSLYAATYDYVGKPFLDVLVREIAKVTLAQTVILQEILTPEENSHETKSATNAAAAATTTESQSTQTKRISFIKTTQPIPPLPSPTFDRSGDERNHDDESPPFSQNHLFVRAVYSTSPLETIKQHTSVPLELLQDTPYIQVLTEGSFGLQDTVEETSCYMPAHHSFAGVRISSSNSDTDGQVLGLLCLMTDTPMHPQALSVATTLLHAVQPRVSRELSRIREEEDLKRAKDAAKLDAENKIRFLADMSHEIRTPMNAVIALTDLLLQERSTLNEEQTEHLEVIQTSGHHLLTVINDILDISKINHDPKFKLESRRFSLRKCVKDALNMARHQASMSQQNKLVSVFECPTDMDENMPLSQMLAELEYMPLPVHKTKTVLPLLYKIDADVPDHLMGDTMRLTQILLNLCSNAVKFTKKGGIRVGIKRYVPIPSQAVQQSSRMSFKQRYDAKMETIWSIVMGNKQTRRQKDGDARAGASDDETEDYDKVILEISVTDTGIGIPADRLPRLFRSFSQIDISTARRYGGTGLGLAISSTLVNRMGGGLWVESEEGVGSRFALTLPMTIAPTRLKERTPSDSFSVVLTSPPSPSSTVSDGGGSINENRIDPLVSPAIINVGPGGGYYHTHSPHIPSPPSSSSCSSPYFNQRSSADISLPLWAPLNAPLNNTKPTTTTNHNSHNNNSNSALPPIPTMALSVSPAVDMYATHSRSIDTKRPSARPHRDIADKTKLTIEARTSRAAVAKQHYHHRKSTNNEENLAVQFPIKIMLAEDNVLNQKIAISILKRLGYHDAVIANNGREALDLMRTTKFDVIFASIMDLYMPELDGLEATRAIINERQTSAVHRPLLNASDVYIIALTASASKQDRQICIDAGMNDFISKPFTMMEMKASIKNCVSKRKPSSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V1M9</accession>
    <name>A0A162V1M9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_139423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297432.1">
        <property type="nucleotide sequence ID" value="XM_018430220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V1M9"/>
    <dbReference type="STRING" id="763407.A0A162V1M9"/>
    <dbReference type="GeneID" id="28991126"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139423"/>
    <dbReference type="InParanoid" id="A0A162V1M9"/>
    <dbReference type="OrthoDB" id="10044727at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD79392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="514" mass="59643" checksum="9AA0A3D686EF32D9" modified="2016-07-06" version="1">MSCPKKRSTIAKKINRSASSEAFIKKIQLENEDYVDLEFDHEDDIVLDNRKLQGISKEAPIELEESIDSELENIQIDKIAVLKLAHEDVKKEILSYTHTGPSSQSVDAFELCKLKSVECYLQYRISGAKTMEASEKALIEIWLHKNTYRPAAIRKRRSLFSDEDIKSTICKWIQNQRPESRSPIEVKKYIDGEILTRKLDISGNTSTKDVIAYHQKWAKRMMVYKKKMTTFSENEETVVLPVLRSDEIEHVLVTHNELTFYANDGKDNMWLMEDENPICKKDPGMSLIISEFKCICYGTMARGAWSSQEVFCPGANRDGYWMSADMLKQLKNNVIPLFELIHPECKDVFSFDQSTNHKVYDQNALILSKMNLNDKEIEDGNPCSLRNTIFVQNDVEKIKYVKDVRHILEELDLWLEKDLYNLIKKWRLDCKSKDTSEDSKCCAHHFLASQPDFMSQKTALHESVKGSDKNIHTFLDHAGKLPNIRQYYNHLWRYIEAYSQEMNVKEVNDVAVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V2J0</accession>
    <name>A0A162V2J0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_179120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the sel-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297552.1">
        <property type="nucleotide sequence ID" value="XM_018438105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V2J0"/>
    <dbReference type="STRING" id="763407.A0A162V2J0"/>
    <dbReference type="GeneID" id="28999011"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179120"/>
    <dbReference type="InParanoid" id="A0A162V2J0"/>
    <dbReference type="OrthoDB" id="9922773at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF160">
        <property type="entry name" value="ERAD-ASSOCIATED E3 UBIQUITIN-PROTEIN LIGASE COMPONENT HRD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="7">
        <location>
            <begin position="447"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD79512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="499" mass="54955" checksum="8055BE05CF739164" modified="2016-07-06" version="1">MAQIQATAQVMDDGMNSTASEIPAFLGLTQQQSSLLVALYNETDPEFAQKLPTAMPIAAQQLSQEYEKRNSVAKKLERANVKYVDECTLFETVQQEAVQALSETDMDIDKAAKGLDLDEKNKDCSVHDLLLGSLLYGGLRREPSGPEDRASLSPVASPNFAGAKRLLERAFEKGYTMAAVQIGSLYTQEEKLASGKNLPGQDPKKLALEWYTKAANKCNPMACHKLGFFYENGIGCKQDIKRAIEYYEQAYEQGYPDSAHNLAIIYQGNSGATVNIKDLEKSISYFERAKQWGYAPSSNALGRLYLLMSKDSKVAADAGNPGNDPEEYVITGMELMENAANSGDPDAMLMLGLIFGSKEYGLYDMAKAQNYMELALIRGELEAYNYLVRILRAKMAAKVALEKENADTFEKLSQSDKEKLIRQLAKEAATSTSTATATSESGKHKKCGNSGCQKVEEEENSFKHCGQCQRVAYCSRECQKEHWKSGHKTVCSSTSNGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V4E7</accession>
    <name>A0A162V4E7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_179295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297903.1">
        <property type="nucleotide sequence ID" value="XM_018438132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V4E7"/>
    <dbReference type="STRING" id="763407.A0A162V4E7"/>
    <dbReference type="GeneID" id="28999038"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179295"/>
    <dbReference type="InParanoid" id="A0A162V4E7"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053027">
        <property type="entry name" value="AGGF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106:SF24">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="153"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="3">
        <location>
            <begin position="358"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD79863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="49262" checksum="4E594962FA69A256" modified="2016-07-06" version="1">MAELDDTFGKELDAYIEARTNPPLDNTDSPTHSHSILSPPPPPPPPPPRKRQQQQQQQKDQEWEHESSTSTSTELSRYLYNEETGLWYDTVTGEYSVYDTATQMYIPVKVINDDEDEDDGSREPKSNAVLRLVVIKSTLFTPGNVVLVDANGLTVGRDRSAWDTRLRLAEMPVSKIHCQIYCESNKNEPESFYIIDVGSRHGTFVNGERLSEPKKSSLPRHLKHQDQLKIGSTVLQVHWHDSSEWPCQQCKVDSCQIIDTTEGKRDKEEKEEEQRQRKKQELFQGNQRRKDLETTRRKELSRLKEIFAVPKKEKETYKDRAEWRRKCEPRVPVSALRQHTIEAEPSVVETVTNQMTPVQGVGDRMLRKMGWQDGQSLGKTGSGGILEPISATPQTERAGLGSQTSERIGSAHESPKTRAWRTAKERYDKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162W703</accession>
    <name>A0A162W703_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_157094</name>
        <name evidence="5" type="ORF">PHYBLDRAFT_158450</name>
        <name evidence="4" type="ORF">PHYBLDRAFT_158532</name>
        <name evidence="3" type="ORF">PHYBLDRAFT_160176</name>
        <name evidence="2" type="ORF">PHYBLDRAFT_160339</name>
        <name evidence="1" type="ORF">PHYBLDRAFT_160915</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">NRRL 1555</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OAD67644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OAD68461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283085.1">
        <property type="nucleotide sequence ID" value="XM_018434303.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285684.1">
        <property type="nucleotide sequence ID" value="XM_018434166.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018434133.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018433807.1"/>
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        <property type="nucleotide sequence ID" value="XM_018433791.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018433564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162W703"/>
    <dbReference type="GeneID" id="28994470"/>
    <dbReference type="GeneID" id="28994697"/>
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    <dbReference type="GeneID" id="28995039"/>
    <dbReference type="GeneID" id="28995072"/>
    <dbReference type="GeneID" id="28995209"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157094"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_158450"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD68461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD74884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD75691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD81244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="80" mass="9059" checksum="E55ABCD9D53456D0" modified="2016-07-06" version="1" fragment="single">MLTLNIDWFQPFDGRTHSSGAIYLSINNLPRSERLKSENVILVGMMPGPKEASTDSMNHYLKPLVDELLEMYIGVEMTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
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    <name>A0A162W7B5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_176420</name>
        <name evidence="2" type="ORF">PHYBLDRAFT_68377</name>
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        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">NRRL 1555</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441016">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OAD70528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018441939.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="29002845"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176420"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_68377"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="193" mass="21944" checksum="275B917406F3BE32" modified="2016-07-06" version="1">MAMGANSVGNGCKFNFYGNQSDVNRQSTYTVCLKNYNNIIFVDVSYQQPIEINSISSDVEIIQEAAISIFKQLVNKIPSLDCCLNEKTIISLRIASLKKLLDFVTNHNISDCQATNFHKNIRAFKSAFAFASIKTDMDERLASKTDDVFTFHINNIIYHNIVAFQSQYSRAAGFSQIYFCNTNKRLTRRTTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WBK2</accession>
    <name>A0A162WBK2_PHYB8</name>
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        <recommendedName>
            <fullName evidence="7">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_10626</name>
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    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
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        <lineage>
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            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441006">
        <property type="protein sequence ID" value="OAD66085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018427939.1"/>
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</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WHY9</accession>
    <name>A0A162WHY9_PHYB8</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">PHYBLDRAFT_63749</name>
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        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
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            <taxon>Phycomycetaceae</taxon>
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                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
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                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
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                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162X7U8</accession>
    <name>A0A162X7U8_PHYB8</name>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_169313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD73055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018436042.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28996948"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169313"/>
    <dbReference type="InParanoid" id="A0A162X7U8"/>
    <dbReference type="OrthoDB" id="2269743at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="549" mass="63379" checksum="79A8C12417AB246C" modified="2016-07-06" version="1">MPKDIYCPYNNIKIKQKRPKRAAFPTATVQNDKISKRFQKESQTFKKSMQQTKRFTDHHQSIRTEAPLSHTRGSPFPLSKNTTKATTTTTTTISNPNPNPNPNKKTNTKTTTNSLKSSSYQPTLATKACVRTPSAPPPPPPSNSRSRSYPYSHSHSHSTFVPSKRHAWSVFGFNSPEEEYSETNRRTSILRSIREAGVCPQIPSKRIKRRQVTSLSQQHQQREPEQQPSPISSVSPIFKPVNSSDNKPLPSPQPSPCIEKEKAPPIDSPLITSPIEQKIFTTDYIKTLYTLMTNNESQETESLNNLHPLTLSCVATKKEQKEKRVVKLEKEEEEEEYEEEEEEEDNEKDRSRLCDEYDSSFTTPNKLHIPLLHDGPVSKQISSDKKALEREYWRRQRRVFLRTRFITDKEATYIARKVYHNTTISSNYRFITSFLSNMANYRTKWRKGLKRIAKKLSVSKEQVIDHSMLDSIWKYWITDPYVDPDLFYSNNDSVARLAAITVCAVYFTLRVMHGHMKEGQYRKALRELDSFGMTCSISLPDPTLNEEQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XBQ1</accession>
    <name>A0A162XBQ1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4460 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_168199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291805.1">
        <property type="nucleotide sequence ID" value="XM_018435816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XBQ1"/>
    <dbReference type="GeneID" id="28996722"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168199"/>
    <dbReference type="InParanoid" id="A0A162XBQ1"/>
    <dbReference type="OrthoDB" id="2097874at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028031">
        <property type="entry name" value="DUF4460"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14687">
        <property type="entry name" value="DUF4460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4460" evidence="1">
        <location>
            <begin position="7"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="239" mass="27454" checksum="EA88FED0801C2370" modified="2016-07-06" version="1">MASSLVKPYLKKFVLRTHPDFFGHDLSRKRCNEDSLQQLYTLLGPLLKKSPPMVKEKTRLAFYDKSSQKQVEGTFDQPTSEWATLQSFLSLCKELGIPIKSSDMDTVRSMVSQSSGTRAARMHKSLKQEFAEALYKGHDTSFRREWTPKTVLENRLLMMGPSVDKNKMAERLCEILPQLKPEIWWGKIPVLIVSPESSLPVTLTKGMLILTSDMQCADIEQYLAANFERKHAEHIEKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y2E0</accession>
    <name>A0A162Y2E0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_79160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD78005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296045.1">
        <property type="nucleotide sequence ID" value="XM_018443438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y2E0"/>
    <dbReference type="STRING" id="763407.A0A162Y2E0"/>
    <dbReference type="GeneID" id="29004343"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_79160"/>
    <dbReference type="InParanoid" id="A0A162Y2E0"/>
    <dbReference type="OrthoDB" id="2263825at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007840912" evidence="1">
        <location>
            <begin position="25"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="309" mass="34321" checksum="D3D170313D2CDD85" modified="2016-07-06" version="1">MQIKGLVVLVATLIGCSLVPTLTALPITSKLPNPDRQPDDVYNVNVDQFAQLVSTHLQFDHLDSIVSATYKEIASQFQHHIEITTQSTDPSSLKPIRTIRLSSIENDQYAFQQPAASSGPDVMDLEILKAQMFGAIQAHTEGDLPVAWDRLADKLGRPALESFVRQLISSHCGTANINHPKRQSFSDLVVLSECLAQNSVLLSSRLDQYISDNLLDIFEALDSKVLPDMLSHTTRDLKDVLDYFNTAFLQDDDQELVLQVKPWVKGALNNSNQPTSLTDRLMALNVYPTNGEEDHPIVIFSHYASLAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZY17</accession>
    <name>A0A162ZY17_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_171795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287811.1">
        <property type="nucleotide sequence ID" value="XM_018436664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZY17"/>
    <dbReference type="GeneID" id="28997570"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171795"/>
    <dbReference type="InParanoid" id="A0A162ZY17"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="145" mass="17105" checksum="5F3F2A3B24963609" modified="2016-07-06" version="1">MVLYMKNIFFFLAHHILCYSVFDLYPFAIQIMKSFYSKGICSTPSYILSFPIWVGLPFTITKSKGQTHWGSRSILVRGRIEDLRLGTKIRENLCWFCLLRKDFVSKFDEENYMTVVSLNEVLTSKVNVFMSYNYAYNNPLMYLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163A1A2</accession>
    <name>A0A163A1A2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase I-specific transcription initiation factor RRN3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_70681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRN3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288441.1">
        <property type="nucleotide sequence ID" value="XM_018442315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163A1A2"/>
    <dbReference type="FunCoup" id="A0A163A1A2">
        <property type="interactions" value="537"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163A1A2"/>
    <dbReference type="GeneID" id="29003221"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70681"/>
    <dbReference type="InParanoid" id="A0A163A1A2"/>
    <dbReference type="OrthoDB" id="26970at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001042">
        <property type="term" value="F:RNA polymerase I core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007991">
        <property type="entry name" value="RNA_pol_I_trans_ini_fac_RRN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790:SF0">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IA RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05327">
        <property type="entry name" value="RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="648"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="648"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD70401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="684" mass="77777" checksum="C83F2FAEC1601319" modified="2016-07-06" version="1">MTSPNIPSDLTMPKNDLLPTTAAAIEQEETIENVTKEKLGYMKLMMKSFIQGALREKDQGNLTRYNELISILSIDPSNPEAPSALKLYVWISVLSQSVSQLDKSCSGLIEAILKVDWAVRTRTFVDAYIDLLENIVSAHAVYVVPVINTLVSGLRFRYNLPPYNCVSRTVIYERNHEAIRSILQLIPTSANSLFVSIVRQTPHHRLSSADQAAFVKNALEIVEYAPVLRRQILSILIDHIAHIQIELDELEEDVDFETYNMDFDDDYQSDNSDNEDEEDDEEDDDDDDIESMYSDDDQENGNVDLKEQMKKIKSMVRKLDAMMVLVFRYFAKCAVQQPAHVKNELYTTLIDIFDRMILKTLKSRYTQFLIFYFCSLDVNAYSDSFVEHLIKNIMDPLRPGVTRISAAAYISSYVARAKFLEPLAIQRIIGTLCAWCEEYVATHDKNLQADVMKHDVFYAVMQAIMYIFCFRWRDLVLEDALDVSLEQEQEEIDVEKNNINIFGQSITTTTTINTNTNTATTNSTSSPSGLNVHIMSAAESGGVVRNWCRGLRNMPYLVMSRLNPLKVCSPAVVKQFAKLAHDTHFMYVYPILEKNKDLLITGVNADNGSSGGKNILQTVQTFFPFDPYKLESSKNFINNIYFEWIAEDDDEDSDEESEDESDGEMSAGLMAMSISPSPIHYMPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163A231</accession>
    <name>A0A163A231_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_69628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288581.1">
        <property type="nucleotide sequence ID" value="XM_018442131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163A231"/>
    <dbReference type="STRING" id="763407.A0A163A231"/>
    <dbReference type="GeneID" id="29003037"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_69628"/>
    <dbReference type="InParanoid" id="A0A163A231"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="222" mass="26034" checksum="E212579C4D108D86" modified="2016-07-06" version="1">MSVSNKINVNFNDMKFEYESNKNAKDTADIDVEDFDTEFLYESYKKYMFLNSNMSENPVYRFVATFTLLKIYKQNFQFLTSLSGLQYMIEFCELFKSIRQFVVCKNYYEIYKENQSIFSHYIFAKTDTHSALQKLADTICNVYNDAVWKELKNSNAVSFVEQSCLLILILILNIDWFQLFDKVTYSSSAIYLTTNNLPHSDQLKAENVILVELMSGLSKPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163A421</accession>
    <name>A0A163A421_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_171007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288971.1">
        <property type="nucleotide sequence ID" value="XM_018436471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163A421"/>
    <dbReference type="GeneID" id="28997377"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171007"/>
    <dbReference type="InParanoid" id="A0A163A421"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="166" mass="19324" checksum="246EEF0A44D53312" modified="2016-07-06" version="1">MTTRHTPLKTANNPRYQKCVCERCSRSVDGYTLQLPRAARIHMHYYPPKQSIKRVYAYHHYIPPKDNAYFHNLGTLYMINCIKIMLILGTACLNSIATTVINLNIEVDGHNKDSYISKNFGSRDFPNDDCASIYRINIQYPNHELHLNRDCTLDSELKRSLDPELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163A9L0</accession>
    <name>A0A163A9L0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_146954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD71971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290011.1">
        <property type="nucleotide sequence ID" value="XM_018431765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163A9L0"/>
    <dbReference type="STRING" id="763407.A0A163A9L0"/>
    <dbReference type="GeneID" id="28992671"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146954"/>
    <dbReference type="InParanoid" id="A0A163A9L0"/>
    <dbReference type="OrthoDB" id="2289822at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="449" mass="50741" checksum="764AC6EDE2DFC38D" modified="2016-07-06" version="1">MNLAHHNAHHGCRACISYGARDSSTTCIVKRDGPSLLRTEESLHQSVGGMYGVKGPNIFKDLPTITSTAFFRLDEMHLLGHGTGQQLYVALGGKFCPRSMTLKHHGYPFALDVSLEDINKAICASRANIPANFTGMWRSLKEFNGKRKAVDWIDFLLFVVPMIVINHFVFDHTKAAVMNLVTAYRIAQQWRTTAANIQEAEEAIGHWHAFLCCEIEEKRLKPTVFVMNQHMLVHLGYMMWEIGSLWAYSCRPTKRTIGVYSMAIKLRKRTSNFEVASNNVAGPQLWSRPTQSSLAELVAAIGIECQNLVRSLVPFWAREGIVSFEENDEVVCANKMWKDLVIYRVRSSVDSRNGQANNLAVLDNAREYGFILKFFSQTVNRVTRLFVAIDCLSDVQRVNQDLFPVWDSLAPGVVKVVDVKSIKGIAGLIHDPNNKAIWRIIWLLPKYNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AIJ0</accession>
    <name>A0A163AIJ0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coatomer WD associated region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_158774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291761.1">
        <property type="nucleotide sequence ID" value="XM_018433853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AIJ0"/>
    <dbReference type="STRING" id="763407.A0A163AIJ0"/>
    <dbReference type="GeneID" id="28994759"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_158774"/>
    <dbReference type="InParanoid" id="A0A163AIJ0"/>
    <dbReference type="OrthoDB" id="5588835at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17546" checksum="7FA3AC4649DA001A" modified="2016-07-06" version="1">MEEDGTPENYAWFISRGAEMCDVGDGVSSKPNTCTLHKLVYPTQPGGAFRLEEVKKYKHEDYHANSWLVKITSNGRYILAPTIYGQIFVFNILTGQLTAILKDHEDIEVRDVIFHPYRPLVFSSGDDGCVKVYTYKTHTDHEGQDMDVALDISIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AKP2</accession>
    <name>A0A163AKP2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_181134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292211.1">
        <property type="nucleotide sequence ID" value="XM_018438422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AKP2"/>
    <dbReference type="STRING" id="763407.A0A163AKP2"/>
    <dbReference type="GeneID" id="28999328"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_181134"/>
    <dbReference type="InParanoid" id="A0A163AKP2"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="99"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD74171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="135" mass="15216" checksum="31AABACCC753302B" modified="2016-07-06" version="1">MDLDQAFKNQDKENKGLIDLEGLSSVLKQTGHSNESTVDLLALVDRIKQRTVTLDHVRRIIAYLDASEDTRNAFHLLAGSEKHGITRTALKEACEKHDIDLRQMNRMMDEADKNQDGLIDFEEFEAVFDKAGVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ATB0</accession>
    <name>A0A163ATB0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_186464</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293681.1">
        <property type="nucleotide sequence ID" value="XM_018439249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ATB0"/>
    <dbReference type="STRING" id="763407.A0A163ATB0"/>
    <dbReference type="GeneID" id="29000155"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_186464"/>
    <dbReference type="InParanoid" id="A0A163ATB0"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045174">
        <property type="term" value="F:glutathione dehydrogenase (ascorbate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041695">
        <property type="entry name" value="GST_C_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005442">
        <property type="entry name" value="GST_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16865">
        <property type="entry name" value="GST_C_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01625">
        <property type="entry name" value="GSTRNSFRASEO"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="88"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD75641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="26462" checksum="AFE1A7D338DC6048" modified="2016-07-06" version="1">MSAERKIVFYNFPGCPYAQRAAITLNETGAKFEEVYIDLANKPEWYHKVNPELKVPAITIDGKTFAESLVIIELLSDLYPEKRLLPSDPFKRASIRFAIEYFATKISSPWYKVLFNYGDETKEGFIKETEAGFTRLGELLREQSETGPYFLGEEYSLADVAIAPFLGRVLLTFKHWVGDYKHKAIQNDKRLEAFVEGILSRPSFKETIKSEEYLIEHFQARFKLPPSGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B6C3</accession>
    <name>A0A163B6C3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_140595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296561.1">
        <property type="nucleotide sequence ID" value="XM_018430432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B6C3"/>
    <dbReference type="GeneID" id="28991338"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_140595"/>
    <dbReference type="InParanoid" id="A0A163B6C3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="66" mass="8154" checksum="C541F7DBB4801278" modified="2016-07-06" version="1">MSCPTRKRRSRKIAVEQSLSSEEEKPSSPSSDQYYEFWMLDRWMYRWFNTKNPHKMKIEHPSIQSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B7G9</accession>
    <name>A0A163B7G9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_62575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296711.1">
        <property type="nucleotide sequence ID" value="XM_018440985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B7G9"/>
    <dbReference type="GeneID" id="29001891"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_62575"/>
    <dbReference type="InParanoid" id="A0A163B7G9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="138" mass="15711" checksum="326BD9751964462A" modified="2016-07-06" version="1">MFGPAENVNIHATCQLDIYTVCQKGSFLQLHRYFEVHCDEQYKKHLWIRSTVSLLCRIFVKPLISYKAFFIEITLVCCLELEQVSNVLGNRFIAIVPMVSQGASVALFNMFGKESPVTASYLRPKSATILLTAMNWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163D0L9</accession>
    <name>A0A163D0L9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHYBLDRAFT_117931</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285900.1">
        <property type="nucleotide sequence ID" value="XM_018428606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163D0L9"/>
    <dbReference type="FunCoup" id="A0A163D0L9">
        <property type="interactions" value="676"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163D0L9"/>
    <dbReference type="GeneID" id="28989512"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_117931"/>
    <dbReference type="InParanoid" id="A0A163D0L9"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000002">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000175">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="40"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAD67860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="442" mass="48687" checksum="436FB4E73D880310" modified="2016-07-06" version="1">MHTPVKFDDVQGVDEAKQELEEIVQFLKNPQKFSELGGKLPKGVLLTGPPGTGKTMLARAVAGEANVPFFFMSGSEFDEVYVGVGARRIRELFAAARMKAPSIVFIDEIDAIGSKRNPKDQSYMKQTLNQLLVDLDGFSQTEGVIFIAATNFPELLDKALTRPGRFDRHVNVPLPDVRGRVEILKQHSQNVQLSSDVDLSVIARGTPGFSGADLANLVNQAAIQASREGCNKVTLKHMEFSKDKIIMGAERRSAISTDESKKLTAYHEGGHALVAYYTPGAMPLHKATIMPRGSALGMTVQLPEMDKDSFTKQEFIAQIDVCMGGRVAEEMLFGTDNVTSGAYSDIAKATDVAKRMVRHYGMSEKVGPVNFDDEDMQLLSSQTKQLIENEIKSLIQQSEDRAKDVLNTHKVELDRLAAALIEYETLNYQEMVDVMAGKPISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163D4J9</accession>
    <name>A0A163D4J9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="15">2.7.7.1</ecNumber>
            <ecNumber evidence="15">2.7.7.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHYBLDRAFT_117128</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the eukaryotic NMN adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="15"/>
    <dbReference type="EC" id="2.7.7.18" evidence="15"/>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286720.1">
        <property type="nucleotide sequence ID" value="XM_018428565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163D4J9"/>
    <dbReference type="FunCoup" id="A0A163D4J9">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163D4J9"/>
    <dbReference type="GeneID" id="28989471"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_117128"/>
    <dbReference type="InParanoid" id="A0A163D4J9"/>
    <dbReference type="OrthoDB" id="422187at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09286">
        <property type="entry name" value="NMNAT_Eukarya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000074">
        <property type="entry name" value="Nicotinamide-nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045094">
        <property type="entry name" value="NMNAT_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00482">
        <property type="entry name" value="nicotinate (nicotinamide) nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15" id="KW-0520">NAD</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 15" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="16">
        <location>
            <begin position="41"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAD68680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="261" mass="29908" checksum="EAEB9AE2E4BC318A" modified="2016-07-06" version="1">MSTAYTSVDLTPGTFDDPYEFPTQYLPKVMKDDSKIPLVLVACGSFSPITYLHLRMFEMAQDHFKERNEYELLTGYYSPVSDSYMKEGLAMAEHRVSMCKLAVETTSNWLMVDSWEPRQKTYQRTAVVLDHFDNELNTIRGGILTSKGNRKIRIMLLAGGDLIASFGHPGVWAPDDLHHIVGYYGSVIIERTGTDVYGFLLSHDILYQHRMNVTVIKQLIHNDISSTKIRLFVKRGMSIKYLLPNPVIDYIHAHRLYLPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DD69</accession>
    <name>A0A163DD69_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_69615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288590.1">
        <property type="nucleotide sequence ID" value="XM_018442127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DD69"/>
    <dbReference type="GeneID" id="29003033"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_69615"/>
    <dbReference type="InParanoid" id="A0A163DD69"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="418" mass="47699" checksum="52D847A6E3913615" modified="2016-07-06" version="1">MAETMVVPMDYVVLKSKIGKGFPYMKADEWKSWVLVYSPILLKAVLPIEMFRNWISFVDACRQLVKPSITFSDIDDGHKFLQEFCTECQRIYTPTILTCNMHLHLHLCETIRDFGPVYGYWLFGFEQYNGLLKNVNTNRKDSFEVTYMNSFVQDTFKGDFVHAALTCPSQVPFLPLLAKLTATAQPSTSKNTITFPQHPFRLSAFIQAYSNPSLPVLGNEPLPPSAFPLLIEPPSAMSDVDYPHLLDYYKVAYCMPNLEGYQHPSSPFSFVDNQIIKLKSINLLGQVYKGCKYASGRGSFVQSLFLGSQGNNRLAYTGQIQYLILHSFTPSVDNTELQTRVVYQDKHVFAFVKWFQIEHDRSRELESVDICSADFIACDFECILPVHRISSVVATCDYKTNTNNKKILVNALPHKQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DP76</accession>
    <name>A0A163DP76_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_73068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290700.1">
        <property type="nucleotide sequence ID" value="XM_018442769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DP76"/>
    <dbReference type="STRING" id="763407.A0A163DP76"/>
    <dbReference type="GeneID" id="29003675"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73068"/>
    <dbReference type="InParanoid" id="A0A163DP76"/>
    <dbReference type="OrthoDB" id="2290219at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19159" checksum="E97FC00AAA07AB46" modified="2016-07-06" version="1">MGGRLCIMEEKSSPQTSISNELTEHLSNKETFDQYKIVTNEEKKAISKENCDPCLTTNQRFLEDLHSAVDTDLPLYAATLHRQQILILIDSGASANYVSPRIKHLATKVSNIPGRSVETAGGHSIKINQKATLTLSLNGYTDIVDAFIFPTKFDLILSCTWLQTAKPVPDWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DT73</accession>
    <name>A0A163DT73_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_145663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291300.1">
        <property type="nucleotide sequence ID" value="XM_018431507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DT73"/>
    <dbReference type="GeneID" id="28992413"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145663"/>
    <dbReference type="InParanoid" id="A0A163DT73"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="18590" checksum="4EEE472BD622A33F" modified="2016-07-06" version="1">MVEKMKTTRQIAQLLGRRTSNRQIGGSNPPSGIFSNFSQKPRNSSLAVVQIAGFRPPVSSKDKPGLQGPFRSPSLFSVVSHSPQYYSILKHCSEALSVIWEAHFQNIVKEVPIVNNQSFKLKSEILLITVAAAAENKLNIKPRVARHWVRKCDEDPKSIFEYSNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DVZ6</accession>
    <name>A0A163DVZ6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_124755</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291790.1">
        <property type="nucleotide sequence ID" value="XM_018429008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DVZ6"/>
    <dbReference type="FunCoup" id="A0A163DVZ6">
        <property type="interactions" value="646"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163DVZ6"/>
    <dbReference type="GeneID" id="28989914"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_124755"/>
    <dbReference type="InParanoid" id="A0A163DVZ6"/>
    <dbReference type="OrthoDB" id="421009at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021538">
        <property type="entry name" value="Syntaxin-5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11416">
        <property type="entry name" value="Syntaxin-5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="245"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="170"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD73750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="336" mass="38028" checksum="D8F365143930E34D" modified="2016-07-06" version="1">MTFKDRTNEFHAIADRIRSRSHVPNALERRSLIQSPSPSGQQASRSEFSLMAAEISRNITSTAGKLEKLTKLAKRKTLFDDKPVEIGELTFIIKQDIAKLNRQIAMLQDYTKRQKQSSKQASEHTSNVVITLQSKLADTSMSFKDVLEIRTENMKMTKDKRDQFLFSAAEQSGPPALANSPLLKSRRRPNNERTQTPVASIGGSGIGNNNGGYVPQDEPESTLSLGIPMLTPQQQQEQMMVLEQDRYIDHRSTAIESIESTIAELGGIFQQLATMVAEQRETVQRIDQNTDDIEMHVMGAQRELLKYYTNISSNRWLIIKIFVTIVCFFLLFTLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DW34</accession>
    <name>A0A163DW34_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetratricopeptide repeat protein 39C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_145239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291810.1">
        <property type="nucleotide sequence ID" value="XM_018431393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DW34"/>
    <dbReference type="GeneID" id="28992299"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145239"/>
    <dbReference type="InParanoid" id="A0A163DW34"/>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="784"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="801"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="816" mass="91864" checksum="4B05C6C7CD1D77F2" modified="2016-07-06" version="1">MPPSQPIPEDSPHKAEDDVHSLVIAKHDTSDTTECPSPASEKSDDDSLEDSPRQELGMVISQLQGILIENEKTFSRDHPEEASSEASGKKVLENPFTENTKLSDGTGFIVPMDHQENGDIYDKQGTQSGSAAQYTNIVSEEIMPPSPGIPPPGHPLEHERSSEDMELESYSDNHIAINKAALKEVKQNTLSPREQEKQDEPMLRAIRHLFNNRFMKAKRLFEKQADSDPLYALGLGSMAFLKAVMTTNEDTTKNAIQVLMTTYNMATAQIDLAMKKSVGDSVVQYFSTYYNYIKYSRGNALPSNMKPASERDIEANKVTFVPNGVLRAHVVKAESCLQIAILQLLQESVVGYIKCGINLRRAYTSYSLVWQEYKRMGQGYNEFIDRDTVSGIQFGIGAVHLVLSALPQKTLRMVSAFGWKADKHLGFALLKICLEDRRVRSPMASLMLLAYYTVLTSLCPQILASEYTQPAIETLLDAQRSSPDSAFFLYFAGRTSRLARNLTLSTQSFMYAIEISKNEWAEVEVLQLCSYEIGFNYMMQHEWEEAANIFDTLYKEKYWSPVILRFLHGACLDMMGLRTEAILAFADVPELEGTKSSSTAHVEKYVLHKVAALQTSGYQDMDMTLCALEFICLMNSFDFMSHEMLDKSIALVDRALGSIAEAEKIEYGIRTRELLPDTPPPQYFDQRGTLLLLKASIYNALGRHQDSIIHLNWIIDHKEQITTDKWVVPFSFWEAGVTSWGTDNRVRAREFWDMSLKYSKYDFEYRLAMRLNLAITKAQELGVPAPEQAKNNGKTSEDMTENSSTTSMSNNSATGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EKV1</accession>
    <name>A0A163EKV1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_162257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297220.1">
        <property type="nucleotide sequence ID" value="XM_018434592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EKV1"/>
    <dbReference type="GeneID" id="28995498"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162257"/>
    <dbReference type="InParanoid" id="A0A163EKV1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007842507" evidence="1">
        <location>
            <begin position="18"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="161" mass="18342" checksum="263A7280F004D401" modified="2016-07-06" version="1">MSLNSFLIILWIHKAKGFDYRWLKRTKEKERLPIHSECCSKVSDKVLVLSYMQLNSDSLAQKSYADLDRPRPSLEPQTFLIGSISGVVKHIKGWEASCLVILKAHAETYSIRLLLHVALRKMAFKGSRVIIMYNILRNEQIPQILAFIVGAFTQSPVEGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167J4W9</accession>
    <name>A0A167J4W9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_69075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441014">
        <property type="protein sequence ID" value="OAD65148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283188.1">
        <property type="nucleotide sequence ID" value="XM_018442051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167J4W9"/>
    <dbReference type="STRING" id="763407.A0A167J4W9"/>
    <dbReference type="GeneID" id="29002957"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_69075"/>
    <dbReference type="InParanoid" id="A0A167J4W9"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF132">
        <property type="entry name" value="PROTEIN-LYSINE METHYLTRANSFERASE C42C1.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="506" mass="58510" checksum="C72947E6BC0BD4F0" modified="2016-07-06" version="1">MNMKKRLTLRKRKLKGMNHSDRLLTRRMVVFFSQPVVIDTRNQQKLLADQPWEIYCPLKNRTSLNEDEGYSRPLYQHSTFYRIVLPCPHQATAEIEKWHRIRLELVNEFGLSLFGAQATECALELRCELLSQNIDSKNWQHDTEHSIHIRPIQADRWDILNNQTIKWPGFFGGGHGGFEYIIRNVSGKQRHLTKTKYVLHCIPTNNTKQTVDALSLAVPISLSNNSLTGYNWQESGHEYSKVDMGRAFMLDPRLTRAKKDIFCMIREVWDAGTPGKLWDSALVIADLIANRLKQQPRCLEKCHVVDLSAGTGCVGLLIKAMCRSMGNRGPKMTLTDLPEALGLIRRNYRLNQSGIDDQVQIEQLRWGVEADARRVTAKAQVDIVLASDVLYVPHAFESLIATLYHLSTSHRTVVYLAYKRRELRDCDEARFFNRCSQYFHINLVQDLSQMSPPVYWEQRFGPLLSLSPLEIWFSRHLTHANQQGHVQVYRLVKKPALFDSPKFRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JH55</accession>
    <name>A0A167JH55_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_80513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441007">
        <property type="protein sequence ID" value="OAD65976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284016.1">
        <property type="nucleotide sequence ID" value="XM_018443590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JH55"/>
    <dbReference type="GeneID" id="29004495"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_80513"/>
    <dbReference type="InParanoid" id="A0A167JH55"/>
    <dbReference type="OrthoDB" id="2257833at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="130" mass="14895" checksum="F0869D9F49F5393D" modified="2016-07-06" version="1">MPENVTEIRLKKRLCCPQSILRQTTDQSTYHKNDDDRLQALYDEAYTELKKSIDSYNNSFVAHMRSLEAMPNRDILAQDSQCPTEDRSIKDLTDRLAAGSIKDYSPLIEHGLKQDPQIGFEEEGACGDLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K2W2</accession>
    <name>A0A167K2W2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_174542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441025">
        <property type="protein sequence ID" value="OAD67157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285197.1">
        <property type="nucleotide sequence ID" value="XM_018437279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K2W2"/>
    <dbReference type="GeneID" id="28998185"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174542"/>
    <dbReference type="InParanoid" id="A0A167K2W2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="30031" checksum="5BBFDD253B4A1347" modified="2016-07-06" version="1">MTVISPARVYTPIMHRLCTTCRRWLMKIYLKSVSNRLEAIKFLSNGWMVCFGSSVVTKCSNSARLKPGTFLILISFGVDRPKVQKKGQKRKYSLCRASPECRLCGHSNQTPEHFLVECPLVWQVWTMAMHMWIPHWRAQPSTILRAFYALALPPSPPHIDSYHVLDGVLAAVWKAYWHTIFDDVPFVPANGDDVSRWETTFSSRRRHFDFTGPQIVTCFPASNNYIWSLRIHTYHNKDTLMQDKIMALAKCKSIIRANVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KHS2</accession>
    <name>A0A167KHS2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_183331</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat WDR59 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286167.1">
        <property type="nucleotide sequence ID" value="XM_018438752.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A167KHS2">
        <property type="interactions" value="227"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167KHS2"/>
    <dbReference type="GeneID" id="28999658"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_183331"/>
    <dbReference type="InParanoid" id="A0A167KHS2"/>
    <dbReference type="OrthoDB" id="311712at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16692">
        <property type="entry name" value="mRING-H2-C3H3C2_WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049567">
        <property type="entry name" value="WDR59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039456">
        <property type="entry name" value="WDR59_mRING-H2-C3H3C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049566">
        <property type="entry name" value="WDR59_RTC1-like_RING_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17120">
        <property type="entry name" value="zf-RING_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="218"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="273"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="316"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="RWD" evidence="6">
        <location>
            <begin position="584"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="453"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="708"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="800"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1196"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="712"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="818"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1201"/>
            <end position="1216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD68127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1438" mass="160218" checksum="BFD0CFECE86C245F" modified="2016-07-06" version="1">MESSQDPTNQPLANLLGNETSNEPTLHRRKSDSNIGNLPTSSRPDTPSTLQMRARRRQSQIGNPLSPAPTPTTTTSTHQDFPVKSISALITQRQQQRQLKRLEPSTPPPPPQPQPSQCQEDTFYQTLEIRLHHSVGSMSISPTCRDVVLAGRQGLVIIDLEDPWLPPRILPHMSKWEVADVQWSPYVSRESWVASTSNQKLIVWNLNHSGSQAIEHVLHAHSRAISDINWSPHHPDILATCSVDTYVHLWDLRCTGQGSDGKDDRSVRPANSFTPWNAATTQVKFNRKSEFLLASAHDKDVKIWDIRKGAVPVTSITAHSKKIYGIDWSRQNDHDIVTCSLDKLVKFWNINTPEKEEEVISTNTPVWRARNTPFGNGVLMMPQRTESKLFLYNRASPEKPVHAFEGHVDSVKEFVWRWKGGSGSEGDEREFQLVTWSKDQNLRLWPVSKDIMKSVGHNPSPRKTMCSGPINEKQQDGPYHPHSFQQMPKANQDDEGHKAMPASVGPLRLTPNSHATTMTPFRASAATIGNSGFSGGYDTLSNAYREQKYAINPLLWMQNVKTVGPAGELRRGAATENTFQTVTGEMSAVLNKYASAGVKTEKINAASRTCTISLHGPWSDTPNAFLRITVRFPPQYPDNSPPEFEIQKNSMMSIYYRAHMAQDLNALASSYTSQKKWCLEACIRYLLGESFQEDGDFNLTAPDAIGSGLPGHSNNGSVASLTSSPGQSGYIPNWSGPNAVDNGDSDDEIFAGPSFMSGLSGYGATGKRVSLQSEKLVDMSSKQSADETVPFPRLCGGVFSGNGKDSKRTAQKQKPVEQDTTARSNTTNGEYFENTYSDFYKHPRTYEQFEEYKEIAAMSRQGRNATVLVAGSGGAFGEYAYDEDPDEMDDGLTSMASLYFKPDSFALSHSLGNRDSLLYRGPKTDRVTYNVVIADFTDMMPYSPWLAKEYILSADDPVSACIHNAEVCKAHDRHDLFKVWSLALEILRECVPLEVPGEQHVAEDGSLAVVGRPEVQLSCNDQAVQRDAKLAELRSVLYANRQRQLNSKKGTNELPSKNMTISRPKQRVKWGKHPLGQKLADNLLQHFILIGDVQTAAMLSCILKDTTKDSQKIPRISSQKMLDVQAMSDDAVLDYFSIKSHTPHNNRVRATLHRAHSGPHTLANSPSRASVNQMSASYGTRGVNLLTYFWLSDRNTSPQHPPEKTTDGHVDEHHDTTPPSPHRVQRTPQPWYPTLKLPSNTAPGIRHAVSMASLTGPHPSGGMATKEGRIVPSNTMSIEFTNTETFDGERFFRLAPTPILNPQGAAQRDVLRLAYADMLYRWSLLDQRAELLKFMSGPIFPDVERTMEINIRCYFCSSEVSSKDLACNNCRKIRSQIRCSLCHVLVRGLVNFCIKCGHGGHNHHIKQWFDMNQSVCPTGCGCYCLIETFDYGSLTTEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KS79</accession>
    <name>A0A167KS79_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_183180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286797.1">
        <property type="nucleotide sequence ID" value="XM_018438730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KS79"/>
    <dbReference type="STRING" id="763407.A0A167KS79"/>
    <dbReference type="GeneID" id="28999636"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_183180"/>
    <dbReference type="InParanoid" id="A0A167KS79"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20534">
        <property type="entry name" value="CYCLIN_CCNM_CCNQ_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048055">
        <property type="entry name" value="Cyclin-Q_first_cyclin_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="1">
        <location>
            <begin position="37"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="315" mass="36077" checksum="402E54793CD995B9" modified="2016-07-06" version="1">MTDTFTDPQNSQLQNDQLDEEHEWKQHVPLMPNLPTLHYLRQASAMLDLPVRTTATAIIYYHRFHKFMALYKGKKQPKNGQWVDDCLPLLTNEELLATTCLHLACKATDIPRKVRDLVNVGYRYYHPNESMLQVDETYFRMRSSLVTSELLLVRTLDYNLEVELPFAFCLNTLRGMGSVQFFGQSTTAFRRHSSKNGPVSAPMSAPGWQKEVWRRMEYEMDPELSAVARLSWMFLWDSICSPKLSMTHSVPGIALGCLYLALRTSNADLPMTMSEWVDMWGASENISVQAVRDVVTDLLALYEATSSSSLFQRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KY57</accession>
    <name>A0A167KY57_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_149559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287196.1">
        <property type="nucleotide sequence ID" value="XM_018432297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KY57"/>
    <dbReference type="STRING" id="763407.A0A167KY57"/>
    <dbReference type="GeneID" id="28993203"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149559"/>
    <dbReference type="InParanoid" id="A0A167KY57"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="389" mass="44436" checksum="AE50263AB29495D0" modified="2016-07-06" version="1">MPGPKEASTDSMNNYLKPLVDKLLELYNGVKMSDNSNENITVRAALMCVACDIPAARKTSGFTGHASICACHKCQRQFTMIPETTQVDFSGFEYSTWIKRTKARNLDYANKWKEAKNAAERTRLKRSNGTRWSQLHLLTYFDPVWCTIIDPMHNLFLGTAKRMVQIWKELEYFDNQALLAMQDLANGVVVPPDYTRINKKIADGFSFMKADEWKSWCLIYSPFVLKRILPVKHLSNWMFFVNACRLSQNPLLLLTTYPVPMPISNSSNLDTNQKGGFEVTMMKRFLEKAYVGNYIQSFEKKFPASTVNFLHSITRSQVILEQPSSMSSSFILSTFVEYSMNPRKSVMGCEPLPSDVLSFKVEPKIVMCKEHYELISNGTAVSIGLEFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L7K0</accession>
    <name>A0A167L7K0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_126696</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287808.1">
        <property type="nucleotide sequence ID" value="XM_018429119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L7K0"/>
    <dbReference type="STRING" id="763407.A0A167L7K0"/>
    <dbReference type="GeneID" id="28990025"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_126696"/>
    <dbReference type="InParanoid" id="A0A167L7K0"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD69768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="152" mass="17584" checksum="5CC54E2BFEDB3DF0" modified="2016-07-06" version="1">MHNHLRTHTGERPFECKISDCNKKFSRLDSLTTHIKTHSDIKPFECPHHDCGKTYYHTRSLRKHEKNHRTERPSQSSEMCIPTTYTFPSSGQITHTHLIDPSSSATSMVSIQQSPIHCYPDSQPHSFQPTPSPNSHPSHYSNGIKKWQTNWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LDN3</accession>
    <name>A0A167LDN3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_159617</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
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                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
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                <person name="Talbot N.J."/>
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                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">NRRL 1555(-)</strain>
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            <begin position="18"/>
            <end position="56"/>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51025"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="238" mass="28457" checksum="FFA3BB49D0903604" modified="2016-07-06" version="1">MDRGSQEFYVSRSRWRKSREDVKRREEERDDEDRRAEQHELDEARRQAEEEERARQETNVLNREPDEITKIEIKPRKLNFNLPIKRVPNMGGNEEEEDEEEGGKRKRVLVPLDYGDDMTIDGTSHLDPEERAQRVKELIGSIPSSEQELWNWPVKWNELDEDLISTKLQPFVSKKIVEIVGVQEDDLVDFILEFIRNKKPPTELVSELEMTLDEEAMMFVMKLWRALIFETERKFQRL</sequence>
</entry>
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    <name>A0A167LDZ6_PHYB8</name>
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                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        </location>
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    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OAD70239.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
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                <person name="Munoz-Torres E."/>
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                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
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                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
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                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="CDD" id="cd22744">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="54224" checksum="E1987E0ADD674D40" modified="2016-07-06" version="1">MIFRDKHNIFDENLELFKSLSSQKDFQSKEQLEDNNDDSTKVVEKRTLEKYFEDEWMPCKEKWAGYLTSQLKHFDYFEGDYQDLELNETTITDARIYHEPRLCGLIHYVSRIGLITICAELLEEVIPGELCNCRVKVVFGLSCRHDLPRDCMLLLSDIPERWILSSSLGERLKQLEWNQQVQNLMAMVDELVDNASEIIDHSNVVFPLASEVKAPGRPKHVKRKTALPNDFVRHKHRHLLVQKNKNDIRIIKEIKKETQFAEKQEPLKEAKTTNFAKKQEPLEEAEKYSSGIKRPKHLQDDYWHNLPSPKKQNKNVHDFALPAQIDQATISLTFNPKSDGWCGFRVFAHLKEGGEDQFPLVKKKILATMATHGKLYEHNFGMDVAKVTEVIAFGSEIDPALGENIPSCPSSVWFSAPDCAQIIADIYNEPVCVYSDDQSVLPVTFLPLHDWKPLKRKSLPMVLHHVHGCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LZ99</accession>
    <name>A0A167LZ99_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_170767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289444.1">
        <property type="nucleotide sequence ID" value="XM_018436426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LZ99"/>
    <dbReference type="GeneID" id="28997332"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170767"/>
    <dbReference type="InParanoid" id="A0A167LZ99"/>
    <dbReference type="OrthoDB" id="10450526at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007890119" evidence="1">
        <location>
            <begin position="22"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="157" mass="17457" checksum="3F269F1629871A3F" modified="2016-07-06" version="1">MLVKTLSLFALGSVTLNLAYAAPLLQQQQSLDGSKRLKAQNTQKCFELTYPLNGTVWNIDGDDGHSHDITWKVVGDCRPENYINIIPVIQDTEDGLVSLGLGDPQYTSQLLDIQSGRARISLDDLEGEGRYVFVIGPLSEDWSDYADLAYTLNIMYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M1Y1</accession>
    <name>A0A167M1Y1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_147290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289584.1">
        <property type="nucleotide sequence ID" value="XM_018431835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M1Y1"/>
    <dbReference type="GeneID" id="28992741"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_147290"/>
    <dbReference type="InParanoid" id="A0A167M1Y1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="69" mass="7970" checksum="B3F4BAABCCBDD3AD" modified="2016-07-06" version="1">MSNINTTLINSMQKIEVVIVEIDQSLRELQKQFSKQFSKQFVQTVSAKDLNTMQQIIIEQSEQTLVVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MCD5</accession>
    <name>A0A167MCD5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RmlD-like substrate binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_177713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290494.1">
        <property type="nucleotide sequence ID" value="XM_018437921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MCD5"/>
    <dbReference type="STRING" id="763407.A0A167MCD5"/>
    <dbReference type="GeneID" id="28998827"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_177713"/>
    <dbReference type="InParanoid" id="A0A167MCD5"/>
    <dbReference type="OrthoDB" id="6235964at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048269">
        <property type="term" value="C:methionine adenosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048270">
        <property type="term" value="F:methionine adenosyltransferase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05254">
        <property type="entry name" value="dTDP_HR_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000357">
        <property type="entry name" value="Methionine adenosyltransferase 2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="DTDP-4-DEHYDRORHAMNOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491:SF4">
        <property type="entry name" value="METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD-like substrate binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="296" mass="32896" checksum="3BF4D80744DC935E" modified="2016-07-06" version="1">MKVIVTGASGLLGRAVYKQLKAANIDVVGTAYSRAKNGLVKLDLANESELEAFIAEQKPNAIVHCAAERRPDVAEKDQEGTRNLNIQVPKRLGSLCKTNNITLIYISTDYVFDGTSPPYEVTDKPNPLNFYGETKLGGEEAIREVNSDAIILRVPILYGDVEYNGESAINILLDSVQNQEKVVDMDNVGKRYPTNVQDIARVIKDLLVKRVDLGEDLKGTFHFTNTECFTKYTICQLFGNLLNLPIDHLKRQDEIPASAAVSRPKDAHLSNKRLEAIGIDTKSVPFVGWWTEYLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MVM5</accession>
    <name>A0A167MVM5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_77532</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292209.1">
        <property type="nucleotide sequence ID" value="XM_018443266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MVM5"/>
    <dbReference type="FunCoup" id="A0A167MVM5">
        <property type="interactions" value="195"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167MVM5"/>
    <dbReference type="GeneID" id="29004171"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_77532"/>
    <dbReference type="InParanoid" id="A0A167MVM5"/>
    <dbReference type="OrthoDB" id="515064at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="535"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD74169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="569" mass="64866" checksum="1807BB2979F012AF" modified="2016-07-06" version="1">MQKNMTPTQLQQLQQQRMAMYAMQSSARLQPTQFQPVPHLYTSMPPPGMAPHAPDLAGWNDPNRAVPNNRMPSFRLTAHPSAAAPPRMGQQFAGQPAGVRPPMTVVPHVETTPVHTPVQKRNLALYRERDNTYQETLNIQHKRHIDLAQEKKRDIELAGAERRAKTQHGPIVGFGPGYNGHGNGTTGGQTRIVYPQQRKRMRHAREFRFALEEMTEQAEKEDALVPIRIDLEIDGYKLRDTFTWNLNETLVTPEQFANVLCEDLRLPAASFAPQITRTLRDQIQDYYLHNASMVTKDDSDQEKEEVAERNENEVAVKKEEEPEDEKKVKSRELRMLIRLDITVGNRALLDQFEWDISCQRNSPEAFAQVMSTELGLGGEFKTAIAHSIREQIYVYIKSLLLVGHEFNDSPVTDDDLKHSFLPVLKSIIREGEQVERFTPALLELTDAEVEKIEKDRMREARRKRRQTRGRRGILLPDREPIKTNRTVYAIPPDHDMTDEQFITSISNPPRAPVSDVTMHSQRRSAMRARINIAAEAAGNQTTHPSQSMQSVISLHSTNRADHTRPHPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N2I5</accession>
    <name>A0A167N2I5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP-dependent DNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_144168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292849.1">
        <property type="nucleotide sequence ID" value="XM_018431154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N2I5"/>
    <dbReference type="STRING" id="763407.A0A167N2I5"/>
    <dbReference type="GeneID" id="28992060"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144168"/>
    <dbReference type="InParanoid" id="A0A167N2I5"/>
    <dbReference type="OrthoDB" id="3691720at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274">
        <property type="entry name" value="DNA HELICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274:SF51">
        <property type="entry name" value="OS03G0423850 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21117" checksum="A8AA57F265A518E8" modified="2016-07-06" version="1">MQFYVFFHSKLDLLDICESGHFFQCKDLTATFKALQVSDVERDLDLTTTTATATATATATATVIPHCSSCNRIGHQWSNSLQCPNNQRNRNFVPSQLTTTHNMAQRTTASATIVTGSSAGKVVLIPRIKLNPTGLIMSIEFKQCQFPVCLAFAMTINKFQGQILDKVGLYLPDHVFGHGQLYVTLSQVQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N3Z0</accession>
    <name>A0A167N3Z0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 15">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHYBLDRAFT_132938</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 15"/>
    <dbReference type="EMBL" id="KV440978">
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        <property type="nucleotide sequence ID" value="XM_018429534.1"/>
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        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 15" id="KW-0328">Glycosyltransferase</keyword>
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    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="126"/>
            <end position="143"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="149"/>
            <end position="169"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="181"/>
            <end position="214"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="550"/>
            <end position="572"/>
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    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="592"/>
            <end position="609"/>
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    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="621"/>
            <end position="640"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="646"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="287"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="349"/>
            <end position="408"/>
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    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="418"/>
            <end position="474"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00012839"/>
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    </evidence>
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    </evidence>
    <sequence length="768" mass="87575" checksum="954530A8ADEE13A4" modified="2016-07-06" version="1">MLAHKEAQKRDWKIVAALTVWAAYVRLWKIWQPSSVVFDEVHFGGFAAKYIRTRFFMDVHPPLAKMLIALVAKLSGFDGVFDFKDIGKDYIESDVPYVPIRVFCGICGLLVVPIAYLTMRGSGHSVAAGLVVALMVCYENGLIANNRLILLDPPLLFFTAATTLMWINFHNQKNKPFQFWWYTWLALTGLGLGLTVSCKWVGLFTIATIGVSTIKNLWDLWGDSRIPNVFVRHFLARAACLIALPVVVYMLMFGIHFHSLPNSGEGDGFMSPEFQQTLAGHSMADTPIDIAYGSNVYLRHVATRGGYLHSHPHDYLTGSKQQQVTLYPHRDNNNWWTIHKSTTNETVGIEYVKDNDIIRLIHRDTGKRLHSHEHRPPMTDLDYHNEVSAYGFPGFNGDANDFWRVEIIDHDKRDPESEDRLRTIHSRFRLIHVMSGCSLFSHSVKLPEWGFGQQEVTCIKSGKIPKTVWYIESTENSQLPDDTEKVNYNRPGFIGKFLELNKVMWDTNKGLTASHPYDSRPSSWPVLKRGINFWGKGDLGLHIYLLGNPLVFWGSTVAIFSYIAIKAVFLLLEKRGFQTDFGGLRKFYDESAGFFLMGWCFHYFPFFLMGRQLFLHHYMPALYFAILLFGVGFDLLTIRLVNRKRLIAAAAFVMCVIYVYRSFIPITYGEPWTKKDCEKAKWLPTWDFDCIQFRDDISAYYPDGKQPKLELMQEAIKSYFAPAESKEQAAAAIDAVNIISDGIVLAAQSDPVLKENPQQQVTDVDAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N893</accession>
    <name>A0A167N893_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 12">3.2.1.106</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHYBLDRAFT_132587</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 12"/>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293344.1">
        <property type="nucleotide sequence ID" value="XM_018429505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N893"/>
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        <property type="interactions" value="488"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167N893"/>
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    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_132587"/>
    <dbReference type="InParanoid" id="A0A167N893"/>
    <dbReference type="OrthoDB" id="410058at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="14">
        <location>
            <begin position="19"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="13">
        <location>
            <begin position="284"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAD75304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="782" mass="90123" checksum="C247496411E2D452" modified="2016-07-06" version="1">MNPTEAGLLLGADHAANESLLWGTYRPNLYFGTRPRVDKSLMTSLMWFDATQFQGFQRKLRVHACDQGDKINGYGYNKHDGRNYAKQTINDGPSNIAITTEFIKIPGGQHGGDWGVRVRGKPMDDDVETITSVMFSLALEGEGSMDIVSKLSPEGLVSPVRLEGDTPELGDFEIHIVDGPSNEHPQGLDQDLSLTQWWGRELPEGVAWREKEIVMENLLMSARQKVSQGDQHDAFERPYAYFTLLNTLTEENEEVSNFYTFQKVFSGEFQFDVLFRSQSSPNKITGDSLETELAQREKTFDARFQEKFRLHEKGFSDEHVGFAQYLLSNMLGGIGYFHGSSVVDRSHHPLEDEENFSDVPIKAELTEPRSLFTATPSRPFFPRGFYWDEGFHELLIGKWDNDLSLDIIKNWVSLIDENGWVAREQILGEEARSKVPTEFQTQFPHYANPPTLYLAIKRYLDRLTEYRQENPINQHTFMATFDNPVLLQSLHLESPEMSKAWLRAVYPKLRLNWQWFRTTQSADLSRFNRKAESKEAYRWRGRTPNHTLTSGLDDYPRGEPPNVGELHVDLLSWMSFATRLLKDISSQLGPEFSTDVQEYSLIEKEMLQNLELLHWNEENQAFCDQTVENGEPIHVCHKGYISIFPVILGLLEPDSPKVKAIFDLIEDENELWSPYGLRSLSASDKFYNTGEDYWRGPIWININYLTLQSLYNNYMRVPGPYQGQAERIYNSLRHNIISAVFKDYQKTGYVWEQYSDKTGEGKRSHPFTGWTSLVLLIMAEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N9J4</accession>
    <name>A0A167N9J4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PABC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_158399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293459.1">
        <property type="nucleotide sequence ID" value="XM_018433779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N9J4"/>
    <dbReference type="GeneID" id="28994685"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_158399"/>
    <dbReference type="InParanoid" id="A0A167N9J4"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PABC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="65" mass="7235" checksum="5A4B8D174ABB0D20" modified="2016-07-06" version="1" fragment="single">KKQKLGDQLFPCVKATGVRQAPKITIRLLDTIPLVELAYCMFDPPALKKKVDRAAISLEQSIHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NKB0</accession>
    <name>A0A167NKB0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_143113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294170.1">
        <property type="nucleotide sequence ID" value="XM_018430937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NKB0"/>
    <dbReference type="GeneID" id="28991843"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143113"/>
    <dbReference type="InParanoid" id="A0A167NKB0"/>
    <dbReference type="OrthoDB" id="2272836at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="334" mass="36862" checksum="D04FDA70709C04DC" modified="2016-07-06" version="1">MLPSYTGSMSIDSNDASDSLSIGDAGSSQDIGVQLASLTGLSTITVGEILEKYQNNVDLLKHILIAKTQEDKRRTAEEIRLAEEARLQNKYLDFELNHHRRSRSEPSFSQDLHHEPSADPLMLPNTSDIDTSWLSSLQAGSDISAMSPFATGSSLHDFNSPPSPSQSIILPSPYMSFDVPFSNLSLSVASSPEPIELAQSLTMSPKASESQASSPGSSSLSKTRYKRRSFTETLRPEGRNKLSGKSIRKSRKSITPPLEEEEENKAKDKQDNEEVSPQSLDHNTVMEALRAKLRRSSQNQKSSKERTPPASSTSVLFLDLHSRRKTFPGRRNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NQH3</accession>
    <name>A0A167NQH3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_180688</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294498.1">
        <property type="nucleotide sequence ID" value="XM_018438353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NQH3"/>
    <dbReference type="STRING" id="763407.A0A167NQH3"/>
    <dbReference type="GeneID" id="28999259"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_180688"/>
    <dbReference type="InParanoid" id="A0A167NQH3"/>
    <dbReference type="OrthoDB" id="10054429at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF26">
        <property type="entry name" value="OS04G0435100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD76458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="61097" checksum="E35A603B51D39AA5" modified="2016-07-06" version="1">MGKSGSCNRTESNQPLVDFQSPQLMTEKKLRRSTMSQHNLWSKQETGLSLNKKQAAYGSISIKTPESVSAEERVNQLGYKQELQRKLSSFATFGLAFTNIGILSNASATFQTVLQRGGPVTMLLSWNIVAGFMLCVALSLSEICSLYPLSGGLYYWVYELLHIHPRAKSHAPLLAFVTGWIYTMANVISISATNVTVALSAGTIMKITYGIPLSKLALMLVTLIITFFQAIMNMRGLGGLALMNQLSVFWSCAGLIAIIAVLSIFAPHQAASWVFTHYENDTGFEDPTYVFILAMIGAAYSLFGCESAASVNEETVDADVSSPLAMTMSIAVSWFVGLVFLIVLLFSVQDIDAVLNSTFDMPVAQLFWDAVGYWGTLGFLFLMIVCQFCTGATTITVASRQVYALARDGATPMSERLCALDSQKLPANAIICTSVLSCIVVLPFPLSENLFETIVSATTITIHLAYGIVLACRLVAPQPIKGRFSLGRWSRPVTYISLAWTMFAVLAFLLPTSWPIQANNANFAGLGLLIVLGSTFACWIGWGRYHYTGPRATTDDISNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NQN7</accession>
    <name>A0A167NQN7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_88243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294509.1">
        <property type="nucleotide sequence ID" value="XM_018443690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NQN7"/>
    <dbReference type="STRING" id="763407.A0A167NQN7"/>
    <dbReference type="GeneID" id="29004595"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_88243"/>
    <dbReference type="InParanoid" id="A0A167NQN7"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042578">
        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF1">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="44482" checksum="D4A33CC1A684D89C" modified="2016-07-06" version="1" fragment="single">IKNVVLLVLENRSFDRMMGWFKYNKDIDGLTGAEFNYVDPSDPSSQKIYATRNGLLKDPLDPAHGYQDVTYQISGDPTLASDASMKEATMGGFVQNFVKTFEQIKDNATAIHQIMDGFEPSKIPITYELASNYTIMNRYFSSFPGSTMPNRLYVHSGTSNGEANTDGTHYIKGYSQKTIYNNLDDAGIEWKNYYEEVPSLIVFTKLRAKLNRFKNWSTFKSDAASGNLPPVSFLDPAYFGIANCIVEDDNHPPADVAQGERLLKDVYETLRASPQWNETLFIVTYDEHGGYHDHVPTPLKAPNPDGVNVTDFNFNRLGVRVPTLLISPWVEKGGVIGKADGPYPDSEYEHSSIPATIKKIFNLPNFLTKRDAWAGTFEGAITENKLRTDCPATLSPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NZ95</accession>
    <name>A0A167NZ95_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_165427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294974.1">
        <property type="nucleotide sequence ID" value="XM_018435239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NZ95"/>
    <dbReference type="GeneID" id="28996145"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165427"/>
    <dbReference type="InParanoid" id="A0A167NZ95"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="130" mass="15236" checksum="B3C8370D67373F5A" modified="2016-07-06" version="1">MRDFIGLGYSELTKDFCTCKGQQPRYSCTLHCNRLIPTKIFVKTVIIPTHFQLKKFLRGRIEDLRLGTKIWENLCRFCLLRKDFVSKFDQVSTLNYYCYLCYFGLGKLYDWGQITVILSGSIVFFSKGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P258</accession>
    <name>A0A167P258_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_185942</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295141.1">
        <property type="nucleotide sequence ID" value="XM_018439172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P258"/>
    <dbReference type="STRING" id="763407.A0A167P258"/>
    <dbReference type="GeneID" id="29000078"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_185942"/>
    <dbReference type="InParanoid" id="A0A167P258"/>
    <dbReference type="OrthoDB" id="3063237at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="19"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD77101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="130" mass="14621" checksum="3EBD3612093608CC" modified="2016-07-06" version="1">MWANNRPNGSTSTNKDNGYVFEQQNDVRMHELGSKLSVLKNITLEMQQDVEDQDRLLNESQNAFGGLGDNLQNSFGRLNRMVSTRHKRQMCFYVGIALAVFTLFYVGSSLASWMPSTPAENPVDSGEQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P3A9</accession>
    <name>A0A167P3A9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_165652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295201.1">
        <property type="nucleotide sequence ID" value="XM_018435273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P3A9"/>
    <dbReference type="STRING" id="763407.A0A167P3A9"/>
    <dbReference type="GeneID" id="28996179"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165652"/>
    <dbReference type="InParanoid" id="A0A167P3A9"/>
    <dbReference type="OrthoDB" id="2290810at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD77161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="490" mass="54453" checksum="CE18CB927374F66D" modified="2016-07-06" version="1">MSLPSAIRLPDDDNNEPPRRHLGFSGCFSCLPSFNSPIRLPDDDPKPSNIANYSPIIPPQQDQPDHAFHRLSAEPNRYLSRNPFGAQEQEPPSVKCLTVQDSTPNVVEAEEVFGEQELMDVPISTNRHAYDNEPDWTEMDQDLFNSEPSSPLAAPAAQLQFSDKGSARELSAVVPLPGVMFEQVDLSTSRQNAQIEALVDETPAKEAAPPLPLTEASLPISVPLKKQDEPLETHRSTVSSVAHSILGDKLEDLTEKLAYIRKNIIMKVEDDEDWDEPQDSPAISHSSPLGYPVTPSMSIQKNTQPRRPSYDPLTSFFSKSPDTTTSRSIDPEPSVPRPRLHRRSSSLLDEVGPTIARFMHQIGGEEGHSFSPSSFFAALAGPSPSEDTDREGDESKQAHGRPHMKSRPSDMAAHYPTLEEESGAEDDFEDLFDFSKVIEMGKNVRTFTDDVVDSGMRIINDVTSRIKHPEQHSDSQEDHNAWMLENESFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P3S1</accession>
    <name>A0A167P3S1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_154816</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295231.1">
        <property type="nucleotide sequence ID" value="XM_018433353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P3S1"/>
    <dbReference type="FunCoup" id="A0A167P3S1">
        <property type="interactions" value="578"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167P3S1"/>
    <dbReference type="GeneID" id="28994259"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_154816"/>
    <dbReference type="InParanoid" id="A0A167P3S1"/>
    <dbReference type="OrthoDB" id="1539250at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3260:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD77191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18227" checksum="04D8510F08EA9373" modified="2016-07-06" version="1">MPHSFGLRARTRHMFSRKFRDHGAIPLSTYLTIYKTGDIVDIKANAAVQKGMPHKFYHGRTGVVYNVTKSAVGVIINKRVGNRYIEKRVNIRVEHIKHSKCRQEFLDRVKDNAQKKQAAKDAGVIVSMKRAPIQPRTARYVSTVKNVPQTITAIPYETLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P506</accession>
    <name>A0A167P506_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_141146</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295299.1">
        <property type="nucleotide sequence ID" value="XM_018430535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P506"/>
    <dbReference type="FunCoup" id="A0A167P506">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167P506"/>
    <dbReference type="GeneID" id="28991441"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141146"/>
    <dbReference type="InParanoid" id="A0A167P506"/>
    <dbReference type="OrthoDB" id="344165at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="6">
        <location>
            <begin position="16"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD77259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="84" mass="9729" checksum="E7ECFBFC3BD9EFD8" modified="2016-07-06" version="1">MSQPQFNESEQRELAQFLEAENAKARIQQTVHSLADTCWDKCIFKVNNKMERSEEACLSSCVDRFLDTSLFIVKRLEELRSSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PEI4</accession>
    <name>A0A167PEI4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_60879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295799.1">
        <property type="nucleotide sequence ID" value="XM_018440712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PEI4"/>
    <dbReference type="GeneID" id="29001618"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_60879"/>
    <dbReference type="InParanoid" id="A0A167PEI4"/>
    <dbReference type="OrthoDB" id="2269335at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="195" mass="22608" checksum="1C4E734806E4A959" modified="2016-07-06" version="1">MRVGEHKPQTHFTVGGNYVLQMPDKIILEEASYHQIKDYLKDILFETWSNMNMIQKLSQDFYFNKEETTKSTLKQQLSDFWDQNGTDSTNSKRIKYRAEKLRLSLTPVVDSRPVSILIKKNLSEQEKLHFKAGFSFNDKHVLDLSKARAIPSRFKDIIDSVLIDAGLQLHPRLTISEYDILIDNLVLKPKVAVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PFR3</accession>
    <name>A0A167PFR3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methionine aminopeptidase</fullName>
            <ecNumber evidence="10">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_76518</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="10">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associates with the 60S ribosomal subunit of the 80S translational complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="10"/>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295864.1">
        <property type="nucleotide sequence ID" value="XM_018443164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PFR3"/>
    <dbReference type="FunCoup" id="A0A167PFR3">
        <property type="interactions" value="736"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167PFR3"/>
    <dbReference type="GeneID" id="29004070"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_76518"/>
    <dbReference type="InParanoid" id="A0A167PFR3"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008970">
        <property type="entry name" value="PRK12318.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="11">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD77824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="356" mass="39537" checksum="111FABF411621A2C" modified="2016-07-06" version="1">MAVVTSPPICASIDCTKEAHLQCPTCVKNNNKEDSFFCSQDCFKKSWGSHKALHQSQRGPYDPFPTFKYAGPLRPVYPLSPRRVVPDSIEKPDYTETGIPKSEFAESRNTSIKVLTPEEIEGVRKACKITREVLEIAAKSIQVGITTDEIDRIVHEATIERGAYPSPLNYNYFPKSCCTSLNEVICHGIPDQRKLVDGDILNIDVSCFYKGFHGDANGTYCVGNVDKAGKKLINVTLECLNKAIAAAKPGVRYRDFGKIIEEHATKNGFSVVRAFCGHGINQLFHCSPNVPHYANNKAIGILKPGHIFTIEPMICEGVYQELLWPDNWTATTKDGKRSAQFEHTLLVTENGVEILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PLM1</accession>
    <name>A0A167PLM1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">ATP synthase subunit d, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ATP7</name>
        <name evidence="12" type="ORF">PHYBLDRAFT_42055</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase d subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296214.1">
        <property type="nucleotide sequence ID" value="XM_018440171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PLM1"/>
    <dbReference type="FunCoup" id="A0A167PLM1">
        <property type="interactions" value="260"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167PLM1"/>
    <dbReference type="GeneID" id="29001077"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_42055"/>
    <dbReference type="InParanoid" id="A0A167PLM1"/>
    <dbReference type="OrthoDB" id="35799at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008689">
        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12700">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005514">
        <property type="entry name" value="ATPase_F0_D_mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161065">
        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD78174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="172" mass="19215" checksum="5A19A52F7370D4E2" modified="2016-07-06" version="1">MASVRAVAKKIDWSKLSVSLPKETAGSLAAFRKRNDEVKRQLAELKAQSTTVDFAVYRKSLKNQAVIDQAEKALKGFKPVAYNLDAQIKAIDQFEAKAVAKAQTTVQQIDVELKDLHATLTNIEDSRPIEQLTVDDIVVAKPEITKNIEDMLQKGKFTIPGYKEKFGDISYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PNZ7</accession>
    <name>A0A167PNZ7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_176814</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296324.1">
        <property type="nucleotide sequence ID" value="XM_018437818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PNZ7"/>
    <dbReference type="STRING" id="763407.A0A167PNZ7"/>
    <dbReference type="GeneID" id="28998724"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176814"/>
    <dbReference type="InParanoid" id="A0A167PNZ7"/>
    <dbReference type="OrthoDB" id="2019556at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080122">
        <property type="term" value="F:AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044610">
        <property type="term" value="F:FMN transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="102"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="205"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD78284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="33473" checksum="A07969489631F3AC" modified="2016-07-06" version="1">MSDNIAHALSGAGGGIVAMILTYPLVNISSRLQVQKNDNDKDAYKNTLDALAKIIAKEGPKGLYSGLSSGIFGIAITNGVYYYCYEAVKAIFEKTKPRGQSMSASESMLSGAIAGATVVLATHPIWTVNTRMTVRKGMEGDNSNKATSKSSSSSAFAVGKSILHHEGIAGLYAGVQAALMLVINPIIQYTVFEQLKSKISKTRALGSFDYFLLGAVSKLCATGITYPYIVVKSRMQVVQEGEERYSSIIDAFKKIISKEGISGLYKGIHSKLLQSVLTAAFLFMAKEALFDWAVWALVLTGARKARIGSNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PSU6</accession>
    <name>A0A167PSU6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_163583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296517.1">
        <property type="nucleotide sequence ID" value="XM_018434836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PSU6"/>
    <dbReference type="GeneID" id="28995742"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_163583"/>
    <dbReference type="InParanoid" id="A0A167PSU6"/>
    <dbReference type="OrthoDB" id="10551837at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="442" mass="50929" checksum="FC6511F758A3A861" modified="2016-07-06" version="1">MDSASIPSRDPSNHHLFSSGEQRIISNEGYESIMLFPKNNFMVKDIILKGRNNNINETSSTSTTITAPTISIKYAFVYGSTLHGNWVYDTLSHEVDDGLTVRMNTYLDKYALKEPVLIFDESSVKECNIPLISSTALANSLRVHEEVVKHLSTDFYITQSQNIVLNIGLQFGDNDGYTFMANQELCLYFQEAADLLESYLKQFPRLAFFVQKLIFSVPRTLSKLYMIGLIQKDIIRREVQRLSKMQLTLKINEKAIERTKKINSEVSLETVVYNIPQSAIVSLKKFKEIHGTKELMIGDRCVCVDRREKNIFLFGKKGTVVGMRNTKKVRVKFDEDLFKASIQSQRLHFAGYKRKITPMQSLYKSSPMGCKCIKYLAMFYRELNVTKKKDCYGRFISYNHSKMDHFSFLYLNMFLALSGRLLAENWPLFLTPIQVVIFIKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PWY0</accession>
    <name>A0A167PWY0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein uL23 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_122071</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296726.1">
        <property type="nucleotide sequence ID" value="XM_018428847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PWY0"/>
    <dbReference type="FunCoup" id="A0A167PWY0">
        <property type="interactions" value="472"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167PWY0"/>
    <dbReference type="GeneID" id="28989753"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_122071"/>
    <dbReference type="InParanoid" id="A0A167PWY0"/>
    <dbReference type="OrthoDB" id="1267328at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000035">
        <property type="entry name" value="60S ribosomal protein L23a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_uL23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_uL23_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005633">
        <property type="entry name" value="Ribosomal_uL23_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011118">
        <property type="entry name" value="PRK14548.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L23A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03939">
        <property type="entry name" value="Ribosomal_L23eN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL23 N-terminal" evidence="8">
        <location>
            <begin position="9"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD78686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="148" mass="16530" checksum="70EE2DAF1949DAEA" modified="2016-07-06" version="1">MAPKSNSAPKNKALAAKKAALKGVSGQTSRKVRTSTHFHIPKTLKLARKPKFARKSIPHAPRMDQYRVIRQPLNTETAMKKIEEHNTLTFIVDVKANKAQIKDAVKRLYDVEAAKINTLIRPDGYKKAFVRLTADVDALDVANKIGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PZT5</accession>
    <name>A0A167PZT5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_163929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296877.1">
        <property type="nucleotide sequence ID" value="XM_018434896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PZT5"/>
    <dbReference type="GeneID" id="28995802"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_163929"/>
    <dbReference type="InParanoid" id="A0A167PZT5"/>
    <dbReference type="OrthoDB" id="10015795at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="75503" checksum="76660B66282C3E47" modified="2016-07-06" version="1">MIKEFPEYQDVLLSVIIKELDLKRSMEVDTEIILTYQSNSVEAIDGQANSPISDAVSTFDNDVFVGNDYNGDESDTTDDNDSDDNGEEDTAKIYLEEFNSPFAASGMPENPVHRFITTFTVLFASHYVVNKGSVVLIEFINELFKIYGQDFQLPKSLAGLHKMTGFLSITKGIKRFVSCPNCHCIYEENMSVPPHCVFTNVGARSPCGLRGTIIDPMHNLFLGTPKRMMDRWVDKKTIGAKEFAAIEKIAETMVLPRDYTKLTSKIGKGFPYMKADDWKSWVLVYSPVLLHDVLPFEMYNNWMNFVRACCYLIKPSITFDEVNSAHDYLEMFCKKATKLYTSTILTCNMHLHLHLRETIRDFGPVYGYWLFGFERYNGLLKHIKTNGKDSFEATYMRSFVQNAFKGDYDNAVLKSSSHVSFFNILSKLSPKFTPTTTVITLSSCPFRLQSFLLASSNPHLPPKGNKPLPPSTFPLQLKKLSLMDETDYAHLLQHYKTSYDLPDLVSYQYATLTNSFVDNEITKLKFIDLLGQQYRGKNGSASCGSLVHVMFVGSDSRNTLVYAGQIQYLFTHSFTHPSNSNLHLTRMVHDHQHVFAYIKWFNTSSDRSHEDDGLEFCLPTFSPDSCHCIVPVHHIFLEIATARITTSRNVSKMLVIALPKKLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q0F1</accession>
    <name>A0A167Q0F1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_62381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296899.1">
        <property type="nucleotide sequence ID" value="XM_018440964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q0F1"/>
    <dbReference type="GeneID" id="29001870"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_62381"/>
    <dbReference type="InParanoid" id="A0A167Q0F1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="203" mass="23059" checksum="57CD3419979803A2" modified="2016-07-06" version="1">MNNTDNNSISLLHAMYNEILSLKADQEKAKLEMKAQIKELKLEMKTSIEDLNLEITALQSQLENRNISNQHTSPSVFAISSANTIRKPVSIFREITLKHIFKMISEDLGIEVTSNKKATLDMCTKLICDDMAAHPSVIALGPNPSWWSIPVALKKEMCARHANIMKDSGIDFTRCLGNWASTARVAHLWRDRHKILQSYFFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q9A0</accession>
    <name>A0A167Q9A0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_139339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297346.1">
        <property type="nucleotide sequence ID" value="XM_018430199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q9A0"/>
    <dbReference type="STRING" id="763407.A0A167Q9A0"/>
    <dbReference type="GeneID" id="28991105"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139339"/>
    <dbReference type="InParanoid" id="A0A167Q9A0"/>
    <dbReference type="OrthoDB" id="8070018at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050938">
        <property type="entry name" value="Collagen_Structural_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456:SF3">
        <property type="entry name" value="COLLAGEN ALPHA-1(XXV) CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456">
        <property type="entry name" value="SI:CH211-266K2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD79306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1082" mass="115661" checksum="6118EA1FBA9B6943" modified="2016-07-06" version="1">MIISSVNIKTFYAFRAAPSPFFSYKNRYNSQFPVIPSLPPGFLSVVLGFRHGRFPAQGTPGRFHVQGTPVRFPAQGTPGQFPAQEPSRRFPKQETPGRFPVQGTPGCFPAQGTLGRFHVLGTPGCFPAQGTLGRFHVLGTPGRFPAQGTLGRFHVLGTPGRFPAQGTLGRFHVLGTPGCFPAQGTLGRFHVLGTPGCFPAQGTLGRFHVLGTPGRFPVQGTLGRFHVLGTPGRFPVQGTLGRFHVLGTPGKFPVQGTLGRFHVLGTPGRFPVQGTLGRFHVLGTPGCFPAQGTLGRFHVLGTPGKFPVQGTLGRFHVLGTPGRFPVQGTLGRFHVLGTPGCFSAQGTLGRFHVLGTPGKFPVQGTLGRFHVQGTPGRFPVQGTLGRFHVLGTPGRFPAQGTLGRFHVLGTPGRFPVQGTLGRFHVQGTPGRFPVQGTLGRFHVLGTPGKFPVQGTLGRFHVLGTPGCFPAQGTLGRFHVLGTPGKFPVQGTLGRFHVLGTPGRFPVQGTLGRFHVLGTPGCFPAQGTLGRFHVLGTPGKFPVQGTLGRFHVLGTPGRFPAQGTLGRFHVLGTPGRFPAQGTLGRFHVLGTPGRFPVQGTLGRFHVQGTPGRFPVQGTLGRFHVLGTPGRFPVQGTLGRFHVLGTPGRFPAQGTLGRFHVLGTPGRFPVQGTLGRFHVLGTPGRFPVQGTLGRFHVLGTPGCFPAQGTLGRFHVLGTPGCFPAQGTLGRFHVQGTPGRFPVQGTLGRFHVLGTPGRFPVQGTLGRFHVLGTPGRFPVQGTLGRFHVLGIPGCFPAQGTLGRFHVQGTPGCFPAQGTLGRFHVLGTPGKFPVQGTLGRFHVLGTPGCFPAQGTLGRFHVLGTPGKFPVQGTLGRFHVLGTPGRFPVQGTLGRFHVLGTPGRFPVQGTLGRFHVLGTPGCFPAQGTLGRFHVQGTPGCFPAQGTLGRFHVLGTPGRFPVQGTLGRFHVLGTPGRFPAQGILGRFHVQGTPRRFLAEEHKRDFMYKDSRTISCTRTQGRFHVPGHKDDFMYQDTRTISCSRTQGRFHVPGHKGDFMFKDTRTISCSRTQGRFHVQGHKDDFMCKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QL96</accession>
    <name>A0A167QL96_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_139889</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the wax synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297917.1">
        <property type="nucleotide sequence ID" value="XM_018430299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QL96"/>
    <dbReference type="STRING" id="763407.A0A167QL96"/>
    <dbReference type="GeneID" id="28991205"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139889"/>
    <dbReference type="InParanoid" id="A0A167QL96"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF57">
        <property type="entry name" value="OS04G0481900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="9">
        <location>
            <begin position="226"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD79877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="413" mass="47988" checksum="7DDE20720ABDAE09" modified="2016-07-06" version="1">MDYQHLFEGGSWRTVLPIPIHLLLFATPAVILGHIATTPTSTLSTQTKQILSFPFLIGVIPLSMAFMCDQKILDILTSLFTYNVFIRFLEIIWLGPVLQGREAYISSRDFHIELWSCLRTFPKPAKEDTKTLKKGETKTYAKDRKFYHIIPLWFANYLICDVLGAWFVTFSAHDAKRVYEENTPLFFFIFAGVVVVMTSAFNILGYTLQLFYVLYYEGGSYSSEQWRELMENPIISTSITSLWAERWHRLLRSTWLAFPYRTTRNVLQKALGKPTKKTAAICSAVASFAVFIVSATMHEFFLYSNLDWPIYREFYMGGQMCYFLVQAALVAFEKVVGTSLRRRLPKSFTESLFALFLQWLWVVVCAFWLFHMFLLGYTTLGVQFNNPFHFFQPYILEYVRKTPAIHPFFGSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QP25</accession>
    <name>A0A167QP25_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_163040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298030.1">
        <property type="nucleotide sequence ID" value="XM_018434724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QP25"/>
    <dbReference type="GeneID" id="28995630"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_163040"/>
    <dbReference type="InParanoid" id="A0A167QP25"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD79990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="151" mass="17651" checksum="15DEC39F4E605820" modified="2016-07-06" version="1">MQDANSSENTHGSYEKADPYKYRCIMYMHLANYGATQISLVVGMSLSTIKCIIKRVDKTGSPEPRKGSGRPRKIDERTEKHLVQIFFDHNKKLFKKRVYIFLFLRDYNFYKIHLGKLKDCSCTPLLQVFLGAFVFKYHEQCGLQDPIFILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QXQ0</accession>
    <name>A0A167QXQ0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_96974</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298474.1">
        <property type="nucleotide sequence ID" value="XM_018443990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QXQ0"/>
    <dbReference type="STRING" id="763407.A0A167QXQ0"/>
    <dbReference type="GeneID" id="29004895"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_96974"/>
    <dbReference type="InParanoid" id="A0A167QXQ0"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046577">
        <property type="term" value="F:long-chain-alcohol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056:SF12">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="7">
        <location>
            <begin position="187"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="233"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="8">
        <location>
            <begin position="535"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="620"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR028937-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD80434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="686" mass="74836" checksum="68709B3FC2A28A91" modified="2016-07-06" version="1" fragment="single">NQEKTLKAILSTILAPLTPEEKESLKKNLSEIPSVTCTQKDIDVISDLGLSTPGVYESFLQFMSVKVLPEDLDGVFGLLDVLGTPEGTKSLTGKAVKFEDLSHEQRTEVCLSWKFSDNPQLVGIFKTFSTAILSAAYNMSDSPHQAAMGYPGQDPIRSAPGYVPCIVRDRYKFMTEKELRDPALKFDAIVIGSGAGGGVCAAELSQAGLSVLVIEKGKYYHESEFTSDVPTAYKNLYLQGGSFASRKGELSILAGSTFGGATTVNFLASLKPQHFVREEWAKLGLTHFTSSKFSEDLDKVYKRIGAETSGIKHNEPNQIFVDGCKKLGCHIEDIPQNTGGLSHECGWCLTGCKDGIKNGTSNSWLRIAAANNARFVDQATVSRVIITDGKATGVEFKINGSDTPISLNASRVVVSAGSLHSPGILSRSGLKNKNIGKHLRLHPVTVIYGLFEDRQVNPFEGSLMTALSNSLENLDGENYGSKLEVPHHTTDMYIFGIPWQGGKEHKERMLRFRQSSSIIALVRDKDSVGSVEHTKDGKVIVNYKLSDQDKISIIKAEERSAMILVAAGAREIHTGFFGMKPFIFEKNEPTEVNNPRFLQWIDALNKNGMPDNAMNYFSAHQLGTCRMGVSPDTSVTQPTGETWEIKDLYVCDASLFPTASGVNPMVTTEAISVHVSDSIVKSIKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167RCU3</accession>
    <name>A0A167RCU3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_129651</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299399.1">
        <property type="nucleotide sequence ID" value="XM_018429299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167RCU3"/>
    <dbReference type="FunCoup" id="A0A167RCU3">
        <property type="interactions" value="168"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167RCU3"/>
    <dbReference type="GeneID" id="28990205"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_129651"/>
    <dbReference type="InParanoid" id="A0A167RCU3"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD81359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="378" mass="44553" checksum="AE46AF3259871F93" modified="2016-07-06" version="1">MPVISSTQRKPILVSLVVFILVIVFFLSPYQSTSIAPSSVPPKNVVPHEFVMPPDEEQFKEPAWKNTTRAKAAFVILTRNSELDDLRKTIQQLEARFNSKFNYPYVFLNDEPFTDEFKELTSGLTKAETKYGLIPQEHWGYPEWIDVEKADKLRHKMGKDGILYGDNLSYRHMCRFESGFFFRHPLMLEYEFYWRVEPSVEFFCDLDYDPFLYMKENNKKYGWTISLLEYESTIPTLWETTKKFMKEYPQYIPENNLIDLISNNGGGSYNLCHFWSNFEIGDLKFLRSPEYTAYFEYLDRAGGFFYERWGDAPVHSIAVGMFLNQSEVHFFNDIGYKHAPFMHCPISRELQKKCHCDAGENFDFTESSCMRKWISVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167RD89</accession>
    <name>A0A167RD89_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_129669</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299429.1">
        <property type="nucleotide sequence ID" value="XM_018429302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167RD89"/>
    <dbReference type="FunCoup" id="A0A167RD89">
        <property type="interactions" value="748"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167RD89"/>
    <dbReference type="GeneID" id="28990208"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_129669"/>
    <dbReference type="InParanoid" id="A0A167RD89"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD81389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="155" mass="17277" checksum="7661FEED2F619D49" modified="2016-07-06" version="1">MQLFVKSLAGNTLALEATPATSVENVKAMIAAREGIDAGFQCLSFAGKSLQDSQALELYGIQDNSTIHLNCELLGGAKKRKKKTYTTPKKIKHKRKKVKMAILKFYKVDQSGKITRLRRECPSATCGAGVFMAWHTDRQYCGKCHLTYVFQKEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N8B6</accession>
    <name>A0A162N8B6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_70255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441000">
        <property type="protein sequence ID" value="OAD66754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284794.1">
        <property type="nucleotide sequence ID" value="XM_018442247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N8B6"/>
    <dbReference type="GeneID" id="29003153"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70255"/>
    <dbReference type="InParanoid" id="A0A162N8B6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="115" mass="12589" checksum="F23FF94E314549A9" modified="2016-07-06" version="1">MGPPPWLTPVGVQLIGPPVHQGHALFIGTWVRTQASHDSGPNYASTMSATLASAINLVQLRNLESQAANALHLNELFKAPTFEVNQQVLLFTKPLSCQGRSEKLTRTWKGPYTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NB47</accession>
    <name>A0A162NB47_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptide hydrolase</fullName>
            <ecNumber evidence="3">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_90360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290808.1">
        <property type="nucleotide sequence ID" value="XM_018443751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NB47"/>
    <dbReference type="GeneID" id="29004656"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_90360"/>
    <dbReference type="InParanoid" id="A0A162NB47"/>
    <dbReference type="OrthoDB" id="3907302at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03880">
        <property type="entry name" value="M28_QC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037457">
        <property type="entry name" value="M28_QC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040234">
        <property type="entry name" value="QC/QCL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283:SF6">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M28" evidence="4">
        <location>
            <begin position="51"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD72768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="278" mass="31541" checksum="1742EA51B8286778" modified="2016-07-06" version="1" fragment="single">LSPLLVPRVSGTPGNTRVREFIVNHFQQLGWHVELDSFVDYTPMGPTKFTNIIVTKNPNSDHHLVMGAHFDSKYYPDFEFIGATDSAVPCAILMDVATTMNDLLDQQPPKQKSLQLIFFDGEEAVREWSSTDSIYGARQVIVIRRGNRLDQIELLVLLDLLGTPNPSINNYYRDTNRLFYRLLSLEKRLLANSLLATVAEDGTELRPVFNPKSSMTFRGEMIGDDHTPFLQRGVEVLHIIPFPFPSVWHNPGDMSECIDPNVVLNFAVIFRAFVAEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NB55</accession>
    <name>A0A162NB55_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_160404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285564.1">
        <property type="nucleotide sequence ID" value="XM_018434177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NB55"/>
    <dbReference type="GeneID" id="28995083"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160404"/>
    <dbReference type="InParanoid" id="A0A162NB55"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="60" mass="5891" checksum="A92C95CCE57FD915" modified="2016-07-06" version="1">MFEFEINLLLTNTGPFLEDPCLGALAVAVAVGAGAGAVALVGGDGCVGAGCYGDVIVEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NHD1</accession>
    <name>A0A162NHD1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_178065</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287724.1">
        <property type="nucleotide sequence ID" value="XM_018437950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NHD1"/>
    <dbReference type="FunCoup" id="A0A162NHD1">
        <property type="interactions" value="323"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NHD1"/>
    <dbReference type="GeneID" id="28998856"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_178065"/>
    <dbReference type="InParanoid" id="A0A162NHD1"/>
    <dbReference type="OrthoDB" id="7340501at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10211">
        <property type="entry name" value="ASKHA_NBD_Arp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000122">
        <property type="entry name" value="ARP5 actin-related protein 5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="347"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="449"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD69684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="703" mass="80347" checksum="68377A8D6547F4DA" modified="2016-07-06" version="1">MADLATAPPIYTLEEKEYPSPYYPIRTDYKSFHSHRTPIVIDNGSYQCRAGWASEDKPSLIFDNVVSKYKDRKTNKTMIAVGMDTYADPAGRSNARSPFDSNVVSDLDRMETILDYIFITLGIKDSRIDHSIVITEPVCNPQHSRRQMSELLFESYGIPSVTYGIDSLFSYHANGGSQDEGGIVISAGHTATHVIPTLHGKGLLERTKRISYGGTQSTDYMLKLMQLKYPTFPTKMTSSQAQELVQEQCYVAKDYQQTLREIEDRSTFAKIDRIVQFPFTAPVVEEKTEEELARQAAKKEENAKRLREAAARSRLEKTQLKESGFKDEADLDETIKQVDIQIQRARNKELGIDDNEEKDPPPTTLIDIPDEELSEADKKEKRKQRLLKASYDARKRAKKAKEEAKAQEEEQARLEEEERRRNPGNWIKGVKDKREKVIDRIKKRKRLAMELADRRSRASQMRMRSIANLASDSPSPKRRRKGQEEDTFGADDDDWMIYREINREDESDDEEEDLSLLNQYESMLLEFDPDFKPEDSYEARSSATNTLMHLLARGVYPPFDPADVGQSHQLHVNIERVRVPEVLFQPSIIGLDQAGLVETVNDVVKTFDSEQKAKVMKHIFLTGGFSRLPGISERIEGSMQSIFPANTAIQVKRAKDPLLDAWKGAAMVALDEKFKNIRVSKKEYEEYGGEYIKEHGLGNIFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NHM1</accession>
    <name>A0A162NHM1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase III subunit RPC8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA-directed RNA polymerase III subunit rpc8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">RNA polymerase III subunit C25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_42578</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287814.1">
        <property type="nucleotide sequence ID" value="XM_018440180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NHM1"/>
    <dbReference type="FunCoup" id="A0A162NHM1">
        <property type="interactions" value="465"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NHM1"/>
    <dbReference type="GeneID" id="29001086"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_42578"/>
    <dbReference type="InParanoid" id="A0A162NHM1"/>
    <dbReference type="OrthoDB" id="10256606at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04330">
        <property type="entry name" value="RNAP_III_Rpc25_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000221">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004519">
        <property type="entry name" value="RNAP_E/RPC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00448">
        <property type="entry name" value="rpoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="9">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="10">
        <location>
            <begin position="83"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD69774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="211" mass="23282" checksum="16EB7C5E1A3B174D" modified="2016-07-06" version="1">MFLLSELEDTVKIVPNDFRKSTTEAITGVLNEKFANKVVQEVGLCICVRDIIEVSEAHILYGDGCTYTKVKFRLVVFKPFVGEVLTGKIKSCSPSGVRVTMGFFDDILIPAPTLQVGSEFDAAEQVWVWNYDGEKLFMDVEEPIRFRILHGLFTDTTPTTHHGAVSGGRRQSVADLSASNDLAANSTKIPPYSLTCTIQEDGLGLLSWWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PIY4</accession>
    <name>A0A162PIY4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_145706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291347.1">
        <property type="nucleotide sequence ID" value="XM_018431518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PIY4"/>
    <dbReference type="GeneID" id="28992424"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145706"/>
    <dbReference type="InParanoid" id="A0A162PIY4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="228" mass="25667" checksum="6BEF3DA67DFD00E2" modified="2016-07-06" version="1">MSALRVSLKHLILDATYSNGLDDSDPIDSSSIIQSFSETLERLSATGFLYNNKNEGVPLELSSYYLFLTNLSICGSNVSHNLNNLLDRCAALEKLKFHGGTLFTNRYMTNEDSKQKKSVNNMSLDTVFIEGSICEKTGYLLVDMSHTFLKTLNISKLRYGTSNQGMYQDVVISLTLLPQLNDNSLSDENNERKEKEMYSECPMSLELTRKGANAALEYYQNFESIKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PS80</accession>
    <name>A0A162PS80_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_166737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293537.1">
        <property type="nucleotide sequence ID" value="XM_018435468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PS80"/>
    <dbReference type="GeneID" id="28996374"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166737"/>
    <dbReference type="InParanoid" id="A0A162PS80"/>
    <dbReference type="OrthoDB" id="10594591at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="366" mass="40808" checksum="EE6F265006654041" modified="2016-07-06" version="1">MDMYRSLSLFTTNIWDTIKNQLYNAWYHIYSSIFWISSLASCTSRPKAQDISTKSTSSVSLNRSISFDLSTLSPKQVHPYDYDQDYDQDQVSYFNRSLFKRHRPPLPNFSNTFTDEPRDHQIPAQPELNSIISAGDREKPTRRSFRNHFQTLKHRQLSLNDVKRSLFPRRQSKVNTADSVPNSPIPSHQIVYLSDPTTPTITDTPTSTTDIIATTTAVDLAGSVPISTSTSTSTSASLPILASVESIKADCIHRRRSVSDVLLRSISAWKQKDSRAISRQEPWNVSAPDLFNPSVQSLNTGSNSPSIPTGLSDLGNLEDLGDPNDFSNLGGFSSSCSSNKDRILSKSQSFALFRRKTTIGSSSNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PSZ8</accession>
    <name>A0A162PSZ8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_143948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293737.1">
        <property type="nucleotide sequence ID" value="XM_018431107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PSZ8"/>
    <dbReference type="STRING" id="763407.A0A162PSZ8"/>
    <dbReference type="GeneID" id="28992013"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143948"/>
    <dbReference type="InParanoid" id="A0A162PSZ8"/>
    <dbReference type="OrthoDB" id="2379842at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22744">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="29124" checksum="176A376327B03B7D" modified="2016-07-06" version="1">MIALEHCINTEKEKITKKIKTEKEQKKQKISSAKEQKAIKRIINLGSPCDSTLLTNLTIAPKHISTIFSPEADGNCGYRAIAMEVYQDQEEWSKVKDKMLETFLKHQNNYYHGRMEHGNMPASNNPLIRSLQDKRSPLPQQHWFGTINHPQLVADTFSRAVAVYWNTPIETGDCLFIPFATLPEKVEPIIIILDTTTAVAAHNSAVISIALSVSKALRSPSVQQVAASARIEVCNSLKILGVDTGHILDINFPAKNVVLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T0M2</accession>
    <name>A0A162T0M2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_153673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441011">
        <property type="protein sequence ID" value="OAD65282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283322.1">
        <property type="nucleotide sequence ID" value="XM_018433224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T0M2"/>
    <dbReference type="GeneID" id="28994130"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153673"/>
    <dbReference type="InParanoid" id="A0A162T0M2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="198" mass="21192" checksum="F236478F01B273E5" modified="2016-07-06" version="1">MHPSIHPPPPISPNLLIDLEKNFRVFWFSFFPFFFVLAVSTGGDDGELLPRVNHGLSSKSTSARVACEPVVRIPVYYWLLSVVSSGGRGWYHLFWSVASASGTFLPVGLLLPTVAGCRLPVASCQLPAAHFPSTGGSIYLTGRSHLSHWSDICFLLLPVASAGELDGSISAAKVSAMSCPQDTSSKADKAHQKPNKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T0Z0</accession>
    <name>A0A162T0Z0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_153614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441029">
        <property type="protein sequence ID" value="OAD65362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283402.1">
        <property type="nucleotide sequence ID" value="XM_018433207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T0Z0"/>
    <dbReference type="STRING" id="763407.A0A162T0Z0"/>
    <dbReference type="GeneID" id="28994113"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153614"/>
    <dbReference type="InParanoid" id="A0A162T0Z0"/>
    <dbReference type="OrthoDB" id="2431110at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="50126" checksum="13EC03A4D3A10291" modified="2016-07-06" version="1">MHNLYLGTAKRMIQIWRECNYINEKNQLTMQELANGIFVPCGYAHITKKIANGFSFMKADEWKSWCVIYSPFVLKHVLPAKNLENWILFVDTCCLLTKPSINDKEIDEAHSKLQLFCTRFQTLYGKSAVTPNMHLYLHLGECVHDFGPIYAFWLFSFERYNSLLKNIKTNQKDGFESTMMKRFLERTYIGSFIQSFVNHLPQFAIDFLHCISNSQDQLAALHPSSTASTFSLSDFVEYSLNPHHSALGCEPLPPSVFPIKLDQRITMCKGHYECLLEFYRHAYGSHNLFGHYSNCESNQIFVNNRIEKMKRISLLGQEYSSGSYFRAYYLENNSEDKAAFPGRILYLFQHLITINETVITHTFAFVEWYSSYSLGSYQPMLNEGIELWNEPSSVLNYECIIPVHRLYSPIAIAKYRFTITSEFKRLVIPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T2L9</accession>
    <name>A0A162T2L9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_184108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441008">
        <property type="protein sequence ID" value="OAD65772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283812.1">
        <property type="nucleotide sequence ID" value="XM_018438884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T2L9"/>
    <dbReference type="STRING" id="763407.A0A162T2L9"/>
    <dbReference type="GeneID" id="28999790"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_184108"/>
    <dbReference type="InParanoid" id="A0A162T2L9"/>
    <dbReference type="OrthoDB" id="2289373at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="33997" checksum="7ECBD420A9F704EB" modified="2016-07-06" version="1" fragment="single">MNPSAENYPAAIIPAHDEDAMSVMTEEDLIASLSDNISFASSTPGQFVAPSPLRPLVANAATTVLSLSEKLRLELQQHVEAVSAAHAMNDEQAAELALNKVRRVKEMIDIEIACSQYLSPSVKVVEKSSRTGGLTLNRRDLPKFQLADDVIRSFPNEEVFHSVDHFLRTFQKVIESSLQDIELVWKRFLPLCLPHSDDGWVEMDLKKCVDWNAAKICFTARHGSRLVTSRSVKEVFTMVMLPSESIGDYSKKFLQAVYDAGLPKNDARVADRFLASLTRQVQTLLRLTMTRLDFNGETKRDWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T9V5</accession>
    <name>A0A162T9V5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_174488</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441025">
        <property type="protein sequence ID" value="OAD67102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285142.1">
        <property type="nucleotide sequence ID" value="XM_018437258.1"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162T9V5"/>
    <dbReference type="GeneID" id="28998164"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174488"/>
    <dbReference type="InParanoid" id="A0A162T9V5"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18659">
        <property type="entry name" value="CD2_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17995">
        <property type="entry name" value="DEXHc_CHD6_7_8_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056342">
        <property type="entry name" value="HTH_CHD6-9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF11">
        <property type="entry name" value="KISMET, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23078">
        <property type="entry name" value="HTH_CHD6-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Chromo" evidence="8">
        <location>
            <begin position="191"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="297"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="593"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="880"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1184"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1277"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1470"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="886"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1184"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1283"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1476"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1498"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1534"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1555"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1596"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1612"/>
            <end position="1625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD67102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1644" mass="188780" checksum="F6A11E53FBA85914" modified="2016-07-06" version="1">MDYPSESHTVYGRPNGFPPLSPRGSRPTPANRSGRAIKQRVDYGESSEEEESDQLSEEEELEEDFLSEEREDSEESEFEDNERSRSKQKPKPTKKSHAQQQNKHWASVDQEIPVFIPMGTKVFERILDYRVNAETGEGELLVKYKNMSFHSAEWVPSSVIENEHLGKHRVKKFMQKWYLDGQKGEDFREYLKVDRVIDEGELADAATGQVAVYYLVKWNGQPYDMCTWESERDIRRIDMSKIEEFQARRIIPSQKLLSKVSIFTRSALQFANIKCVHRYRYNNELRTYQLEGLNWLRFCYNSHRSCILADEMGLGKTVQSVAFLNDMYHTLGIRGPFLVVAPLSTIPHWERAFKAWTDLNVVDYRGSVLSRNLLVETEFYYKDIQGRTIPNRYKFDVLITTYEMAMAGVSQLRQVPWKCAVFDEAHRLKNKQSKVLEILKTFDIEHKILLTGTPLQNNLDELYSLLHFMQPEVFSDEKHFFTEYGSLQSAAEVEKLQALLKPIMLRRFKEDVEKSIPVKEETVVEVELTTPQKKWYRAVLEKNFSFLKKGAKTNREMPHLRNIMMQLRKCCIHPYLLEGAEEVIVSESNAKGPVEQFNCLIQSSGKLASAYRQTSSKINSSCLDILADYLRGRSYAYERIDGSVPGDQRQAAIDRFSTLPIEDSFVFLLCTRAGGVGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQTKPVQIYRLICANTYERDMFDRAGMKLGLDKAVMSRSGVAGDQEDGGQGKSEISKKEIEDLLKKGAYGAMLDDEASAKFCEEDIDQILERRTTIIRHEGNEKGSVFSKATFSTTEDSGTVELDDPDFWEKWAAKANIDTTEMPDDNELIVYEPRRRRQVQRFGSRLADGIYSSNDNAEDSDAYDDEVEKSKKKDQPRLWSLSEKTKYERKLMIYGYGRWDLMKAHFPRRSEKDLKAVTRAVMRRVLPIIEHSNEEEKKLIDDIEYILETDAAEEVPGDETVPYSGATKKQITEFRSFLIQAPADYLDHVERKGRNFLLRIQMLYMIRDKIVPKDWEDAKALTVPKVTGHPPSDWWEHDEDRDLLLGICKHGYQQYLAMRNDPEFCFYGRKYDDSKAGTLEDDDAAPLIVDTDSTPVSVSVDTDERMDDTEDNVRVYMWPSKADIGMRLRRIIAAFLREQANDLRKLKIMEKEQKKEHNRLVREQEKESRKAEKQREKLNETSNRWPKKSRADFLRTILSFGVETYPDDRSTICWDRFKEIAGLEKRTDESLNLYYQKFIPACEEMMKRHEQEQSGTERSTTANSNQDPSTSSPSSSLQAPNAEQGIDISAASRESSAEPGGDSNADKDEQNEAVDLVPYDKARRTLKRIAQMKRIREEVMVHPDIDSLLENARKTSGLPSWWEVPLHDKALLEGICKHGIGRHDLMVDDPALPFFQVKQHVLDEESRNQPENDNSTSLMEKIGWPKDLVIARRIEALCELITKPKPPPKRPASSRKRKRGDPKPVARANTSSMGKSTSIKLTLRGPREKDGYNSDVSISSSPMDIEDGTDSGEDTDTILREATKRMRNKRKGRSPTKPLKSQAARHHDESSVGSYHRHKKTFLARQPSSSSSTPDTWRNGNMRPRSPSYSSSMSSDSDDQGGPLRKSVGSSNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TDS8</accession>
    <name>A0A162TDS8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_79062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285832.1">
        <property type="nucleotide sequence ID" value="XM_018443418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TDS8"/>
    <dbReference type="GeneID" id="29004323"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_79062"/>
    <dbReference type="InParanoid" id="A0A162TDS8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="165" mass="16196" checksum="207A1FAF5B17B46C" modified="2016-07-06" version="1">MMTEQAAAAGEFDGEFGAGAGAGAGAGSVVGFGFGDVGVEVEVAAVGSADFDVVDVVGIVGAAVAGSVGAAAAVVVDVDIVDVDVVDVVDVVDVVDVVVVGVGGVGGVGVGAAAADGDVELLEKNIAWVPKSLDIHYSLPYFDQLLGTFGSNSIAEFQEHERQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TE48</accession>
    <name>A0A162TE48_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_152484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441003">
        <property type="protein sequence ID" value="OAD66413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284453.1">
        <property type="nucleotide sequence ID" value="XM_018432927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TE48"/>
    <dbReference type="GeneID" id="28993833"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152484"/>
    <dbReference type="InParanoid" id="A0A162TE48"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="439" mass="47589" checksum="BB110D7885DA66DE" modified="2016-07-06" version="1">MRWNKTEWNEFITTEEGFEKENSVLLLSVECGGVGVGAGFKKENVTVVVGFNFDSAVELVLCGGVGVGAGFKKENVTEIVGFNFDSAVELVLCGGVGVGTGFKKENVTVVVGFNFDSAVELVLCGGVGVGTGFKKENVTVVVGFNFDSAVELVLCGGVGVGAGFKKENVTEIVGFNFDSAVELVLCGGVGVGTGFKKENVTVVVGFNFDSAVELVLCGGVSVGTGFKKENVTEIVASIKVSDVDYSSEKILRLKKNLYEENDNQAKMIYLSVFNVFTLEQTFNADSVVKEGILIYIGVLSIIHELIVIRRCGDQDTYYLWVVNHSNFNDEYAEDNNFGTQIIVLRRFINTPFGYRVAKVTLGFTHGLWNMFTNRLVGTLSNKISSKIICICNGDSITEDPEEEAETRAFLESDGNSGSKLLVHLLLTREFRKPEVALLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TFH0</accession>
    <name>A0A162TFH0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_160253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286212.1">
        <property type="nucleotide sequence ID" value="XM_018434149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TFH0"/>
    <dbReference type="GeneID" id="28995055"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160253"/>
    <dbReference type="InParanoid" id="A0A162TFH0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="61" mass="6881" checksum="26C864546DB4AF7D" modified="2016-07-06" version="1">MNVVMKTDDHRTVTTAGTLPQSGAIRHGSRTGRHCCEARVKMCYMCFMPCSPWPPLQLCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TPK8</accession>
    <name>A0A162TPK8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_148629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288102.1">
        <property type="nucleotide sequence ID" value="XM_018432119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TPK8"/>
    <dbReference type="GeneID" id="28993025"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148629"/>
    <dbReference type="InParanoid" id="A0A162TPK8"/>
    <dbReference type="OrthoDB" id="747268at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="1">
        <location>
            <begin position="243"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="406" mass="46964" checksum="26F4A7D69D579604" modified="2016-07-06" version="1">MNQVPAYRFLNWRNPCITIKRKLKLNLLNTSYYASAHTEILMNPTRSFFQDLLHILVTNNYVIVSETYSKKYNAALTKFNSIFLIGREFSSTVAFCEATKAYGTKHNIAFTTYSSSSTFSVNQKTPISEWERQQLEPEAIILVVQHLEENDDVSTIFNNLKRSEYTSFICQDIKNIKQQFRKPEEGREIFSFITALQELDFYVRYSIGDNKTNSHQMTYVNIVDISNVSGTPHTTMKTFPIAGAWVDHKTIDNYLWVLFCLHNSVWPDVNDSSSSYTTTATLLLPSVFITDNEKALRNAITNAFPECKQLLCYKHIKNNFKKQLLSMMKKDKNGDKRDFLNELASYLDQITLKCTTSKEEKKEIDAYLRFAKDNCKDQEKSTKAFLESILTLEIALPTMQKVHMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TPN0</accession>
    <name>A0A162TPN0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_73877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288112.1">
        <property type="nucleotide sequence ID" value="XM_018442935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TPN0"/>
    <dbReference type="STRING" id="763407.A0A162TPN0"/>
    <dbReference type="GeneID" id="29003841"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73877"/>
    <dbReference type="InParanoid" id="A0A162TPN0"/>
    <dbReference type="OrthoDB" id="2285485at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="406" mass="46571" checksum="C5352DC8B9B36F6B" modified="2016-07-06" version="1">MYFDDISARLRPLEDFKVGNPSKNIYQPSIYTQLSTFSGSSFFALDELHLIARGIGKLVYDLITITITKETKFYYTHPDNTLNTTEYPFHIPRADLVTIGNCITSSQKYIPTSFQGSFDNVFAKIDGTRAVDWLDFLLYLVPTLVVPYLPNRAVKTALLSLVKGCALALQWTLTSELLDEMESYFKHWHSFLYQQVQNNTLSRSVFRPVQHYLVHISYIIKQQGPLRCYSTRSMERVIGVFSKLIKSKSKGGRNASFLVERFAIHNYTSTAISICDEINLIRPKPYGRESYMDLPNDPSGAQLWEPFHQFVNLNDDSVEGVGGPSVKEALLKYYQRTTGLTGHKFGDSVVVVAARLWMDSTVYSSCMYRRKKNETSRGNHYVMFTCPYRNNRNVIVHSWLVDKKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TRD3</accession>
    <name>A0A162TRD3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_66869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287203.1">
        <property type="nucleotide sequence ID" value="XM_018441697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TRD3"/>
    <dbReference type="GeneID" id="29002603"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_66869"/>
    <dbReference type="InParanoid" id="A0A162TRD3"/>
    <dbReference type="OrthoDB" id="2272589at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="382" mass="43631" checksum="23449A11E1EF45FF" modified="2016-07-06" version="1">MSSNGESADFNVESDVLNLDAEMEAVFIGANPIAATMNVYLDGDSSTQTFYHQENNTECFSEYISPFKSKAAFILHVLFHSNKDLSSERSIKKIMFAIEKLDFTKPDAKNEIPVFPTTTCTAVNRKGQCHEFSINKPSEYIRHILACPGKTAQMSSLSDFTENQWLNLNQGTKYKENPMFQNPMIISEGSDYWMLPLIVDDFVELEKGIVMYSKDHDEDVLVVAPLLVFMGDNPWQSQLAMHSKTLRKHFCRKCHLEAPQSTQKDNTAEISYLPGNHNGAEKITKEFLYAFVTVNTDSELYKHRCGLNYSKNGSKEFLRLEAFDAIKNMPIEILHTIPLGLSQYLVTYLFKFSRMSTAEIARLEPALSSYRVCKSYNRRFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TRG6</accession>
    <name>A0A162TRG6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carbohydrate-binding module family 13 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_66848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287223.1">
        <property type="nucleotide sequence ID" value="XM_018441695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TRG6"/>
    <dbReference type="STRING" id="763407.A0A162TRG6"/>
    <dbReference type="GeneID" id="29002601"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_66848"/>
    <dbReference type="InParanoid" id="A0A162TRG6"/>
    <dbReference type="OrthoDB" id="2263926at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15728" checksum="03BBA9966DE4233E" modified="2016-07-06" version="1">MAGFPHGWFFITSTNGHVLTITPISFQRLTTNKVSQASRIELRPNVEGDHQLWSHDDGYLVNKLSGCVLAIKNQPSKGQCLTSVMREPLENAEHQRWEFNTNCLTLISNHDWSLSDQPVPRCVASEDGVDWVCCPKSCSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TXR5</accession>
    <name>A0A162TXR5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_69489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288713.1">
        <property type="nucleotide sequence ID" value="XM_018442101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TXR5"/>
    <dbReference type="FunCoup" id="A0A162TXR5">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="GeneID" id="29003007"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_69489"/>
    <dbReference type="InParanoid" id="A0A162TXR5"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="56"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD70673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="351" mass="38405" checksum="799870B341970397" modified="2016-07-06" version="1">MSLNTQVIYTKPPTGFPVVGETVKTSKSTIDLDAPLQKGDILLKNLVLSIDPYIRGCMRDPAIASYAPAFEYNSVLAGDTVAVVLKSDNPKFNQGDLVCGRTGLGYFEEYSHVKGTYADSNYVVRNDSKTNGLPLSYYVGILGMPGLTAYVGLNKYGRPQKGETLFVSAASGAVGQIVGQIGKTLGLYVVGSAGSDDKVEYLKELGFDGAFNYKTENIDSKLTELCPNGIDIYFDNVGGTMLEHALDHANNFGRIIGCGMISQYNTQDQYGIRNLIYVVSKRLSFDGFVVLDKENMAYEEEFIKTCTQWVLEGKVKYRETIVDGIENTPQAVLDVFKGRNFGKQIVNVANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TZQ4</accession>
    <name>A0A162TZQ4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_169450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290352.1">
        <property type="nucleotide sequence ID" value="XM_018436074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TZQ4"/>
    <dbReference type="GeneID" id="28996980"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169450"/>
    <dbReference type="InParanoid" id="A0A162TZQ4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="175" mass="20784" checksum="17A99CD5FFA17735" modified="2016-07-06" version="1">MSPENPIPCTLRLITQFMHSITKYLDKIGSRTETSRRSSYPRSGEPMKKQPEKHLSIPPSSKELTNISWDQALREEHLLYHEPLIFYGQRFWMNSWVRQMRRYIELNDIKDEEVMKIIPKLLGGEALEWYNKQAEWVDPEQKIKVAKLSKLITGNQLKLLQICLGRNYNICQLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U206</accession>
    <name>A0A162U206_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_147446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289733.1">
        <property type="nucleotide sequence ID" value="XM_018431865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U206"/>
    <dbReference type="GeneID" id="28992771"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_147446"/>
    <dbReference type="InParanoid" id="A0A162U206"/>
    <dbReference type="OrthoDB" id="10424057at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="59" mass="6740" checksum="BD352E89C4F5CAA6" modified="2016-07-06" version="1">MAGANTPVLSNLRISAYAETRMLTSISVRHYLRQGNPAAVNSTNERIHPFIDRRWLTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U545</accession>
    <name>A0A162U545_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_155485</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Lipid-anchor</topology>
            <topology evidence="10">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291542.1">
        <property type="nucleotide sequence ID" value="XM_018433411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U545"/>
    <dbReference type="FunCoup" id="A0A162U545">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162U545"/>
    <dbReference type="GeneID" id="28994317"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_155485"/>
    <dbReference type="InParanoid" id="A0A162U545"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF2">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9 10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007747942" description="1,3-beta-glucanosyltransferase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="12">
        <location>
            <begin position="364"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="503"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD73502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="524" mass="56971" checksum="226C5BB5C594807A" modified="2016-07-06" version="1">MRSGFIISILCAVATVQALNPIVIKGHKFFDSVTKNQVFIKGVAYQPRSDGISNGDPLSDASACARDASLMAKIGMNVIDPRKNHDACMKSFADNGIYLLLDIATPKYSVNRNSPEYNVHQYNSYTAAIDAFGHYDNIFAFIAGNEVTNDRTNTKASPYVKAVIRDTKNYIRETQKRKIPVGYASNDDEFIRGAIKDYFACGDSDTQADFFGVNLYEWCGDSTFQKSGFADRTKEFETYSKPVFLSEYGCNLVSPRKFGEVAALYGPDMTDVWSGGVVYEWTQENNNYGLVKIDSSTGKVELLPDYNNLQNALAKANPKGVTLDNFNEQRAEPDCPANDDSWKASVALPPTPSEGACECMQNNLACVASDKVSNTDSTSMLTNSSSIIGIQIDSLCGMVSCNDIGSNGETGHYGAYSFCSPESKLSWLYSLYVQDNQASRCDFNGFARQEYPKRNDIGSCSKIGPTINSSGREFVDAKKSAATVYNPNVLISSTALIAINSSSSSSSSGSSGGSSSNTIQYNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U7N3</accession>
    <name>A0A162U7N3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_63947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292142.1">
        <property type="nucleotide sequence ID" value="XM_018441208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U7N3"/>
    <dbReference type="STRING" id="763407.A0A162U7N3"/>
    <dbReference type="GeneID" id="29002114"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63947"/>
    <dbReference type="InParanoid" id="A0A162U7N3"/>
    <dbReference type="OrthoDB" id="2288587at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="271" mass="30530" checksum="2B977F07BC298E23" modified="2016-07-06" version="1">MENGKKALANEEIYTTRVTHGGRHPGSMEAEGLGIPFDLIERGGEWKDQLGRLETHYLSKLPSPFTREWIAVCEKEMDEVDENEDEDENIINLDIDKEVDSVEFVEEDGRNQSKEKKRKGKQRATQSIKTSMSTQKKLPLSSNSSEMLQEYIVAAITSPSVGRLEEYENLVPKIVDTNKEVASRGTEDLLLINMTQQLAKDIKILMIQQQRLNSQMQLLMAINNASQSINTNASLSQPPIFPVLSTTHSMSPLLSLTLLLLLLSLSRNQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U7T5</accession>
    <name>A0A162U7T5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_177427</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292172.1">
        <property type="nucleotide sequence ID" value="XM_018437885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U7T5"/>
    <dbReference type="FunCoup" id="A0A162U7T5">
        <property type="interactions" value="301"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162U7T5"/>
    <dbReference type="GeneID" id="28998791"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_177427"/>
    <dbReference type="InParanoid" id="A0A162U7T5"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000011">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF9">
        <property type="entry name" value="ANION_PROTON EXCHANGE TRANSPORTER GEF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="674"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD74132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="779" mass="87206" checksum="E6F8798E54CB717D" modified="2016-07-06" version="1">MTQARTSTAQLEEELAQIRRYEDFSTIDWVKDAIIERYRQSSIQTQNRNDTSWRAWRKLTYETTQTWIVVTLVGAAIGLNSALIAIVTDWLSDIKLGYCSEAWWLNQKFCCWEIEARDGSCENWIHWSQALHMGPDVFVVKWIFYVFWATLFATTCAYLVKVFAPYAAGSGISEIKCILAGFVMRGFLGSWTLMMKSVGLTMAVASNLSIGKEGPSVHMACCVGNVISRCFQKFRTSKAEMREILTASSAAGVAVAFGSPIGGVLFALEEMSSTFPNRTMWKSFFCAMIATMVLQAMNPFRTGKLVMFQVSYDREWHFFEYLFVVVIGIFGGLYGALVIKFNLIVAQLRKRYLKNYGVSEAAALAFFTALIAYPNVFMRIDMTEIMGILFRECEGAQGENYYGLCETNGVGRLVVLLLVATVLRTIGTIVTYGCRVPCGIFVPSMAIGATFGRMIGLLVKAWQVSNPDFFLFASCNPDMPCITPGTYAFLGAAAALCGVMRITVSVVVIMFELTGQITYILPTMIALMITRAVGDWFGADGIADRYIRLNGYPFLDKEDHVFGVPVSHVMQSEMTVMTATGMKFKEIDEILRNTNFQGFPVVQDNKSMAFIGYIGRSELRYLLDKARSVYKAHDTTGVRFSPDTNEDPEVLTSTSDVDHVIPGSSDFLDFGPYVDQTPITVHPKLYLETVMDMFKQLGPRVVLLEQGGKLVGLVTIKDVLRYMARIETSNTTDEAIDDMEQSDCMRSLMAWISRRSGRTGTYTQLNSQPEEEIHELHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UBD8</accession>
    <name>A0A162UBD8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-phosphogluconate dehydrogenase NADP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_124225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293022.1">
        <property type="nucleotide sequence ID" value="XM_018428980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UBD8"/>
    <dbReference type="STRING" id="763407.A0A162UBD8"/>
    <dbReference type="GeneID" id="28989886"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_124225"/>
    <dbReference type="InParanoid" id="A0A162UBD8"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF8">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE NADP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="4">
        <location>
            <begin position="5"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD74982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="304" mass="32009" checksum="3A2A6ECA4D98B21F" modified="2016-07-06" version="1">MPLQCAYIGLGAMGYPMAGHIANHLQTLKYPSLLVHNRTLGRAESLASSVPSRVARSIAECAIADVVFTCLLNDAIVEQTVTSLLEAGLKKGAIIVEQSTVAPALVDSLAAKARASGVFYLACPIMGPPQRAQSADLVVLMAGPKAQQAIVKPLLIPAIGKKAIELGEDPAESIRLKLCGNFLVTSSCEMLAEALTLGEAAGIPQDKVGELVGSVFSSPLLNIYTTRMVQKTYNDQVHFSLTGAKKDGTHIHNMGIASGIKLPITEAFLNNVKSAHDKRGDIDITGIVGAVREGAGLDFDLKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UCD6</accession>
    <name>A0A162UCD6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_166460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293232.1">
        <property type="nucleotide sequence ID" value="XM_018435420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UCD6"/>
    <dbReference type="GeneID" id="28996326"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166460"/>
    <dbReference type="InParanoid" id="A0A162UCD6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007840092" evidence="2">
        <location>
            <begin position="17"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD75192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="168" mass="18832" checksum="F8E6E6BFB3F62162" modified="2016-07-06" version="1">MFLSMGFSCLRTLLMGVYTPVYVCLQSCGDYSIRHGNLWPANDQAVYQVSQTYKWYCANALILCLQWFPADYIAIFRSCTSVWQGGFSVRDATLVNTLESVACWKSYDDLGVSFLDCPPSYILDLQETYARTFFYIVSTVFVTVTLAILAIANGTLCSSSMTINCARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UD14</accession>
    <name>A0A162UD14_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_186733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292243.1">
        <property type="nucleotide sequence ID" value="XM_018439276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UD14"/>
    <dbReference type="GeneID" id="29000182"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_186733"/>
    <dbReference type="InParanoid" id="A0A162UD14"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="339" mass="35725" checksum="015201D2A520E8DA" modified="2016-07-06" version="1">MLAVVIYSVNVERADCGNSSVVIYSANVERADCGNSSVVIYSANVERADCGNSSVVIYSVNVERADCGNSSVVIYSANVERADCGNSSVVIYSVNVERADCGNSSAVVIYSANVERADCGNSSVVIYSANVERADCGNSSVVIYSANVERADCGNSSAVVIYSANVERADCGNSSVVIYSANVERADCGNSSAVVIYSANVERADCGNSSVVIYSANVERADCGNSSVVIYSANVERADCGNSSAVVIYSANVERADCGNSSGNSPYFCLMLAVVIYSTNVKRADCGNISGNSPYFYLMLAVVIYSANAGYVGYGNSSGKILPLAYIFKQVLFKFRNYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UMC7</accession>
    <name>A0A162UMC7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_154955</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294363.1">
        <property type="nucleotide sequence ID" value="XM_018433368.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A162UMC7">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UMC7"/>
    <dbReference type="GeneID" id="28994274"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_154955"/>
    <dbReference type="InParanoid" id="A0A162UMC7"/>
    <dbReference type="OrthoDB" id="1880850at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056261">
        <property type="entry name" value="FKS1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23605">
        <property type="entry name" value="FKS1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="534"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1142"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1194"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1315"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1398"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1439"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1469"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1508"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1579"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1636"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="13">
        <location>
            <begin position="145"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="108"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD76323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1674" mass="192442" checksum="2899741CEAD69748" modified="2016-07-06" version="1">MVQKKNSSSGIPVAPPPAPDLPKAWGPKDAIPITPREIEAILQNLGRKFGFQNDSVRNIFDHLMTMLDSRASRVKPQIAIDTLHADYIGGEGANYRKWYFAAQMDILDDEANNEKRIVEEDLDEAQLLEKAEERWKLRMRALTNDEKIRDLGLYLLIWGEAAAVRFTPETLCFLYKLASDYYCHGECPDIPEGTYVDDIATPLYRFFRDQTYELINGRYAKREKDHDEIIGYDDVNQFFWHPTCLSRILLTDEKTQLGDLPIHERWLHLKEANWKLAFRKTYKEKRTWMHVSINFTRVWIIHIVSFWYYVSANAPSLYLDPDPEIAKLESSVQWSIVALGGMIAVMLMLIGSFSEYSYLPMSWANTKMISRRIMILFVLLLINAGPSVYCVFLDRQSGISKLVALAQLLISIATTLFLAITPASRLFVRSTKKNVRSTLANRQFTANFPHLKKIDRIMSISLWILVFSCKLLESYFFLALSFKDPLKVMSKMSIENCQDKIMGTLLCTYMPNITLALMFMMDLVLYFLDTYLWYIIWNTVFSVARSFYLGISIWSPWRNIFSRLPKRIFVKLLASSDIQIQYKPKILCSQIWNAIVITMYREHLITVEHVQRMLYQQEINPVNGQRTLKPPSFFVSQEDTAFKTEYFPQHGEAERRIHFFAQSLTTPMPQPRPVECMPTFTVLVPHYGEKTLLTLREIIREEDQNTRVTLLEYLKQLHPVEWENFVMDTKIMVDEANCIDSVESGGSIIGMNEKDTVKTKIDDLPFYCIGFKSSKPEYTLRTRIWASLRSQTLYRTISGFMNYRKAIKLLYRVENPDTIHRYQDNQEKLESDLDRLSRRKFKLLIAMQRYAKFQKQEAEDAEFLFRSYPDLQVAYVEEVPPEKEGDEITYYSVLIDGRSKILENGKREPRLRVRLPGNPILGDGKSDNQNHAIIFYRGEFLQLIDANQDNYLEECLKIRNVLGEFENLEPTEISPYSPAWQNVETSPVAIVGAREYIFSENVGVLGDVAAGKEQTFGTLTQRIMAKIGGKLHYGHPDFLNAIFMTTRGGVSKAQKGLHLNEDIYAGMNAFTRGGRIKHTEYFQCGKGRDLGFGSILNFTTKIGTGMGEQMLSREYYYIGTQLPLDRFLTFYYAHPGFHINNIFIILSVQMFMLALLFIGAMGSTLLVCEYNADAPPDAPLIPAGCYNMVPIFEWVKRCILSIFVVFFVSFLPLFLQELTERGFWRGLTRLGRHFVSLSPLFEIFVTQIYTNSVLENLVYGGAQYIGTGRGFATSRIPFSVLYSRFSGASVYLGARNLLIMLFISLAVWIPHLIYFWFTVIALIISPFVFNPNQFALIDFLVDYREFIRWLSRGNSKSHKSSWINETRSLRTRITGYKRRLTENAIVTSDTPRARIGSVFFSEIVIPLCNAILCVVPYVFVKSFDPDDSALPSTGPSGLIRIGVLAFAPILLNAGALAIFFFVSISLGSILSLCCVKFGSVMAALAHGWSVLNLIIIFEGLMLLEDWKLLNIVLGLISMVALQRFVLKVFTVMFLTREFKHDESNRGWWTGKWYGRGLGWHAISQPLREYLCKIVEMSEFAVDFVLGHFILFFLSVFCLIPYINTAHSLMLFWLRPSKQIRPPIWTAKQVRTRKKIAITYGILFLGLFLSFTGLLVAPLILGKGLKLVNTRKLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UQX4</accession>
    <name>A0A162UQX4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynactin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_185983</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295243.1">
        <property type="nucleotide sequence ID" value="XM_018439178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UQX4"/>
    <dbReference type="STRING" id="763407.A0A162UQX4"/>
    <dbReference type="GeneID" id="29000084"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_185983"/>
    <dbReference type="InParanoid" id="A0A162UQX4"/>
    <dbReference type="OrthoDB" id="2355at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04646">
        <property type="entry name" value="LbH_Dynactin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027777">
        <property type="entry name" value="DCTN6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072">
        <property type="entry name" value="DYNACTIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072:SF0">
        <property type="entry name" value="DYNACTIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD77203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="172" mass="18725" checksum="7812A5A88AD97D06" modified="2016-07-06" version="1">MSRNRITAGPKSIVCLETNLRGEISIGSGSILHPQCRVIAENGPIYIGRNNIIEENAVIFNKNATPLVIGDENVFGVACYVEGSRIGNSNVIEARGRVLGSTTMGNFCVISAACSTETNETIPDLTVIYGAKSNRRTQTEVLPAQATVHARHLDYLRETLPKYNHLKKLDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V007</accession>
    <name>A0A162V007_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zn(2)-C6 fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_106384</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297133.1">
        <property type="nucleotide sequence ID" value="XM_018427946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V007"/>
    <dbReference type="STRING" id="763407.A0A162V007"/>
    <dbReference type="GeneID" id="28988852"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_106384"/>
    <dbReference type="InParanoid" id="A0A162V007"/>
    <dbReference type="OrthoDB" id="65716at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000002">
        <property type="entry name" value="Zn cluster transcription factor Rds2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053045">
        <property type="entry name" value="Zinc_cluster_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986">
        <property type="entry name" value="REGULATOR OF DRUG SENSITIVITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986:SF7">
        <property type="entry name" value="REGULATOR OF DRUG SENSITIVITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="32"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="94"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD79093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="349" mass="39144" checksum="24EF388039FD929B" modified="2016-07-06" version="1" fragment="single">ACVYCRRSHMTCDDGRPCQRCIKRSIGHMCHDEPKESASSSGSTTNSAAPKGSRESSITSDSDYKSSVKRVIPPTKYQSNDFLDSMGNVNLLLGNQHNNSNVNSSSNSSRGGGGRGGGTPVTESPIVNTTEKFFLTAADPSDGRLEDRLTEVINAKYEAGFLKPYNYVNGYARLQKYMDRHMSASSRQRILNVMGTFRPAFRSVAQSLTDIDLILVEEAFERLLLDYDRVFSSMGIPACLWRRTGEIYKGNKEFASLVNVPMETLREGRLCIYELMAEESSVNYWEKYGNIAFDPGQKAVLTSCLLRNPDREETSVISCCFSFTIRRDKYNIPVSITHLQYFLFVCLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V3K8</accession>
    <name>A0A162V3K8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_179214</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297753.1">
        <property type="nucleotide sequence ID" value="XM_018438117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V3K8"/>
    <dbReference type="STRING" id="763407.A0A162V3K8"/>
    <dbReference type="GeneID" id="28999023"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179214"/>
    <dbReference type="InParanoid" id="A0A162V3K8"/>
    <dbReference type="OrthoDB" id="264603at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033149">
        <property type="term" value="F:FFAT motif binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016763">
        <property type="entry name" value="VAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809:SF6">
        <property type="entry name" value="AT11025P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="8">
        <location>
            <begin position="2"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="160"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD79713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="241" mass="27124" checksum="88C0B0906227D2D3" modified="2016-07-06" version="1">MSLKIIPGDQLEFVRPLTRVVSSTLRLYNPGTSDVAFKVKTTAPRQYCVRPNAGLIKPQATMEVQVMFQPLPEEPPIGFKCKDKFLVQSVQVSDHSEDIALPDLWANVEATNKQSIEQKKLRCAFVDEVVQAPPQVEEEKKVGSPAPDAAPVTVEPEVVNNQTQEEMSDARETIKMMQQKLESYEQEMNLLRRRKEESAQEVFAPVQPAVVVVPAKSSYFYSLLTLAVLVNILALYYIMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V8Y8</accession>
    <name>A0A162V8Y8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_138425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298912.1">
        <property type="nucleotide sequence ID" value="XM_018429997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V8Y8"/>
    <dbReference type="STRING" id="763407.A0A162V8Y8"/>
    <dbReference type="GeneID" id="28990903"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138425"/>
    <dbReference type="InParanoid" id="A0A162V8Y8"/>
    <dbReference type="OrthoDB" id="2404451at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="785" mass="88894" checksum="14CB83306DF32845" modified="2016-07-06" version="1">MTEIDQSILNDVDMYHDENNTSNEDESCACNFEDSEGEAHIYDSSQISTNTFTKAKLMSIHLSQLMLQHRIARAAYRDIVQFINTVIRDHDDIMMERGAKISHGETVDALLKSKSSVKGHEYDICSSGCRLYGINDNQESCVDCGKPRYKTDPNQSQTPAANMKLMSVGDMLSQMLADPATRELLCYRANRESVAGQLTNIFDGDNYKQLVQQGLFSNPNDIAIGLYTNGPIHQKPTHLDSFLIPIINELRDLEAHGLVVKHNGVELCRSKVYLLLASGNIPAVADMAHIGSHTSLFGCRFCKTKGKCPTNRRHGMYFDDISTWLRPLKDFKVGNPSKNIYQPSIYTQLSTFSGSSFFALDELHLIARGIGKLMYDLITVTLTKETKFYYTHPDNTLNTTEYPFHIPRTDLVTIGNCITSLQKYIPTSFQGSFDNIFANIDGTRIVDWLDFLLYLVPTLVMPYLPNRAVKTALLSLVKGCALALQWTLTSELLDEMESYFKHWHSFLYQQQQGPLQCYSTRSMERVIGVFSKLIKSKSKGGRNASFLVERFAIHNYTSTAISICDEINLIQPKPYGRESYMDLPNDPSGAQLWEPFHQFVNLNNDLVEGVGGPSVKEALLKYYWRTTGLTGHEFGDSVVVVVARLWMDLTKNETSRGNHYVMFTCPYRNNRNVIVHSWLVGTVQFYFQHVDFYGFPHFLAFVEVMKEHDTAGHDSSVPIVKQRSQSTNTLGHQTQPTYAVISVNDICHQVGLVQYPPNGNQFYVIAPYYIFNNNMRITKGNLSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V956</accession>
    <name>A0A162V956_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_161557</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298962.1">
        <property type="nucleotide sequence ID" value="XM_018434430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V956"/>
    <dbReference type="FunCoup" id="A0A162V956">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162V956"/>
    <dbReference type="GeneID" id="28995336"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161557"/>
    <dbReference type="InParanoid" id="A0A162V956"/>
    <dbReference type="OrthoDB" id="10054429at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF26">
        <property type="entry name" value="OS04G0435100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD80922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="584" mass="64341" checksum="0316BA3547821282" modified="2016-07-06" version="1">MIKVFTDFLRRFSSNSNIDHKFQHFAVCRDLKLCAEVEETGTRCHISEDDILASFGYKQEMHKTMSTVSNFSIAFGCCSILSGLSPMWGDAMQSGGSVAIIYGWILVSIFTFGVGLSLAEICSAYPVTGGLYVWVSRLAPPEWVPIACWLTGWCNWLGLTVAITSADLGLAQFLSSVIGIKNPDYDAGIYWQYGIFLVIVFIHGMINSVSVKYNGFFNQTSLYWHLIGTLLIIIVALVMTPNKSSAKWVFTDFQNETGFSSNGYVFLIGLLQSQYTLSGFDSAAHMSEETRDAARSAPRGILYAIGVAALVGLAFMLSVNFCVQDFDAQVVNAKISPQMTQVFLDGVGYKWTIVFTVIIMGAMFFSGSALTLGSSRMVYAFARDGAMPFSSWLSYVNPRTKTPVYAVWANVIFAAIVGLLYIVNTTAFNAIVSINTIASSLAYFIPIALRLTTARKSFQKGPFNLGPFSNIINLVSCFWILFTSVLFLCPTEYPVTASNMNYACAPLVFVLGGSIGYYHFRARKWFTGPGRSLEPDPQIDGPAVTEEYFSGDYSPDKVTSYARHADGENLHHRRGSVGDDENKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162W9D9</accession>
    <name>A0A162W9D9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytosol aminopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_2604</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441009">
        <property type="protein sequence ID" value="OAD65605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283645.1">
        <property type="nucleotide sequence ID" value="XM_018439880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162W9D9"/>
    <dbReference type="FunCoup" id="A0A162W9D9">
        <property type="interactions" value="477"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162W9D9"/>
    <dbReference type="GeneID" id="29000786"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_2604"/>
    <dbReference type="InParanoid" id="A0A162W9D9"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF23">
        <property type="entry name" value="CYTOSOL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M17 leucyl aminopeptidase N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="5">
        <location>
            <begin position="117"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD65605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="48670" checksum="D8A126C775C41412" modified="2016-07-06" version="1" fragment="single">KQGDVRMLYNIGGVKQVAIVGLGKKSGEDQAKIQDAVRTAAATGVRALQGQGAKYIGVDVSVDAHGASEGASLAQFSFDKLKVEKARRKEIVVGPFSESSVEDITWESGQIYGASQNLARMLMTSPANLMTPKLFSDEVAYLLAGLENTDVLVHDEEWAARNNMNAFLSVSKGSQEPLRFLEIHYKGGKESDPTHALVGKGVTFDAGGISLKPSNNMALMKGDMGGAATVAGALYGIIKLGLPVNVVAVTPLCENMPSGDATKPGDVVKAMNGKSIEVLDTDAEGRLILADALYYVTSKYKPSSVIDLATLTGAMDVALGEVFAGVFTNSDDLWKKLDKAGQTVSDPFWRMPLNAGYLKEMQTSLVADLNNLGKGRSGGACSAAAFLKEFVNGLETPVESPGPRDTTEVVETTTNDSIAWAHIDIAGVMDSQSTHGYHIKGMSGRPTRALIEYIKSVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WG78</accession>
    <name>A0A162WG78_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_174648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD66935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284975.1">
        <property type="nucleotide sequence ID" value="XM_018437298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WG78"/>
    <dbReference type="STRING" id="763407.A0A162WG78"/>
    <dbReference type="GeneID" id="28998204"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174648"/>
    <dbReference type="InParanoid" id="A0A162WG78"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100">
        <property type="entry name" value="IMP2'P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100:SF4">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="189"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD66935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="359" mass="40278" checksum="25F35F0A4A69CF9C" modified="2016-07-06" version="1">MSTSSPQPKETPKSNPEYPFPTEEPIRRPWLKEELDDINTVDDESSSSKTSPTSSEEGIVLQNVLPSHQDFSQVDMLWDEMTDIQARQRSDSDSTDESDWDEEDEELLKRTESNRVIPPEEGEETTGPTADLKRIVSVRQRLLSEQRHLLVFTDPEIVVEPSRATFTLYYGVRPAGSGTNSRKPRSYFVACDFSEESFYAIEWTIGTMMRDGDRLYVTTVVNREDNPDAAQIDGMTPSGELESAAGIVTEKVKGYMAKMLLFDIKVSVFAVSGRVKDVLKQMIRELTLTMVVCGSRGRSTMKGLLMGSISTYLVHKSPVPVTVIRPQKFKQKQKKHHVAAASLSESVKTGHLHVDELAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WH26</accession>
    <name>A0A162WH26_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_166755</name>
        <name evidence="2" type="ORF">PHYBLDRAFT_174773</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD67065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285105.1">
        <property type="nucleotide sequence ID" value="XM_018437333.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293558.1">
        <property type="nucleotide sequence ID" value="XM_018435475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WH26"/>
    <dbReference type="GeneID" id="28996381"/>
    <dbReference type="GeneID" id="28998239"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166755"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174773"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD75518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="742" mass="84637" checksum="618E6D4960EB99E2" modified="2016-07-06" version="1">MSTIPELYNEKCHCAGCSQNDLGYSFVARRTAQRHNKRARLNAIRCERDMSTQRNMMEVDDEPILTHQPGALEESYTQTNSPVWEGASMSDTEDVSVTNDAISNGDNDDSGSNSNEISEDESEDDVIELDDNELNSEDPFATPDMPQNPVHRFIATFVVMFASRYVVDKGAVVLIEFINKLLTIYEQDFQLPLSLPGLQRMTGFSAMTKGIKKFVVCQDCHKVYEESASVPSHCDFVKLGARSSCNCQLTKTSASGALVAKRSYLYQSVLHRLGYLDLVRGTIIDPMHNLFLGTPKRLMDRWIKDEDIQDGDFAAMQKTAETMIVPGGYTSLNSKIGKQFSYMKADEWKSWVLVYSPVLLKDVLAKDRFENWINFVDACRLLIKPTITFDEVNTAHQFLQTFCTRCDELYNAEILTCNMHLHLHLRDTIRDFGPVYGYWLFGFERFNGLLKNLKTNRKIGFEETFMKKFIEDVHKDDLVNSFLQSTRQTSAFPLLTKLTSSFTPATIPSIRQRTFRIQSFVEASEDPNVLVKGNEPLPPSAFPLSLKSATTMSDIHYVHLLQYYKVAYNNEQLVHFQQASESPYFVDNTITLLKYINILGQVYKGKGESGSRGSLVQAKFIGSTGEHIIAYTGQIQYIFTHSFTPPPTSSSLTPLLRTHRRPTQLLHNSQHTFAFIKWYTPENDKSREYEHVETCFPTFSPDDFQCVLPVHRIMLEVATAEHTTRRKVKKMLVIPLPKKQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YJ08</accession>
    <name>A0A162YJ08_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_184532</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299075.1">
        <property type="nucleotide sequence ID" value="XM_018438947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YJ08"/>
    <dbReference type="STRING" id="763407.A0A162YJ08"/>
    <dbReference type="GeneID" id="28999853"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_184532"/>
    <dbReference type="InParanoid" id="A0A162YJ08"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057939">
        <property type="entry name" value="TRF2_HOY1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45793">
        <property type="entry name" value="HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45793:SF5">
        <property type="entry name" value="HOMEOTIC PROTEIN OCELLILESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24818">
        <property type="entry name" value="PH_TRF2_HOY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD81035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="375" mass="43280" checksum="96D9D6E8FDB36094" modified="2016-07-06" version="1">MNQSSPLRESSSEDAITKKRTRVTPGQLTVLEETFIATATPDNKMRKQLAHQLQMPERSIQIWFQNRRAKVKMLQKRDLLREEQEATRARMYAKASSYKSSWYPSLGYNRPQVKMPIQRAWSTDNQPLPPSIPNFYPFLVDDISTPSMAPFDTMSTRNLYSISPSPSLYPMHISDNRQRRTADSELSIQSQPNISVNSPSHLITVNTVTVGSWHRMKIDREDLLCQCDFRDRTLTWFIRDSVYNFKMVLPFDIISVMRLSILEDSILATIDIDLIEPPMFYMENGGTDMTNGGFNWIQCSDFTEGIQATCILRHTLQGLAVDLRREMLAMAGADEQLCQIMRFPTQQDPQMSQFDQMLAQNWRHQSVPVHGFQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZDK6</accession>
    <name>A0A162ZDK6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_79652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441006">
        <property type="protein sequence ID" value="OAD66061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284101.1">
        <property type="nucleotide sequence ID" value="XM_018443487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZDK6"/>
    <dbReference type="FunCoup" id="A0A162ZDK6">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162ZDK6"/>
    <dbReference type="GeneID" id="29004392"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_79652"/>
    <dbReference type="InParanoid" id="A0A162ZDK6"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000073">
        <property type="entry name" value="esterase OVCA2 isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD66061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="236" mass="25836" checksum="8BFA8E6E2E6DC1AD" modified="2016-07-06" version="1" fragment="single">MSTPNKLRILCLHGMVQNGPVFRKKTAVIRKKLDKIAELIYVTAPHLIVDPRYTSDAHREAAADEHAPEESKPFGWWHPTPSGATPEGYYQGFRESVDYLKNILIEQGPFDGVFGFSQGAGLAAVMSELLENRGVMPSLVSKDFGHPAFKFAIICAGFKLISQEATQSLFSVPINTPSMHIYGEQDTLIVPEKAIALSELFVNPVILTHPGGHVVPSNAACRNEITAFVTKFATTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZKX7</accession>
    <name>A0A162ZKX7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase PFA4</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Protein S-acyltransferase</fullName>
            <shortName evidence="11">PAT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Protein fatty acyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PFA4</name>
        <name evidence="15" type="ORF">PHYBLDRAFT_183527</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11 12">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11 12">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285541.1">
        <property type="nucleotide sequence ID" value="XM_018438788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZKX7"/>
    <dbReference type="STRING" id="763407.A0A162ZKX7"/>
    <dbReference type="GeneID" id="28999694"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_183527"/>
    <dbReference type="InParanoid" id="A0A162ZKX7"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03199">
        <property type="entry name" value="DHHC_PAT_PFA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033682">
        <property type="entry name" value="PFA4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="14">
        <location>
            <begin position="91"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="308"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" description="S-palmitoyl cysteine intermediate" evidence="11">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAD67501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="402" mass="46015" checksum="4BB96D26515EF73F" modified="2016-07-06" version="1">MLESIPGKVFVVGVVLLIAMIAYSSQLMVFGPALGGLTLKAFWFLAPLNVLVAMVFYNYYLAVTTDPGKVPSDWVPAVVIKENKQLGITGPRVCKACNIYKPPRSHHCRYCKRCVLKMDHHCPWIDNCVGHGNYPHFMRFVIYVDFACSYVVGLLIWRVRTILDSMRHFQFDADPNTSEIVFMVLNFVLAFVVLFCVGILSVYHLYCIAKNQSTIEGWERGKVEKLVRRSKIPPVVYPFDISIYKNICSVFGNNPFLWLWPQTPKSNGIDFALCNDADPAVVFYWPPRDPDDLRPSIFSIQYKRQQEKKYRQSTNQEVEDSVSDDYYDSGSFASDSDYPSDDEYRGSRHSQQLEESLYGLSGISPHENAYQRRGWESEPEDDDSVPLANLMPRKSPKESKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZLP8</accession>
    <name>A0A162ZLP8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_151177</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285701.1">
        <property type="nucleotide sequence ID" value="XM_018432622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZLP8"/>
    <dbReference type="STRING" id="763407.A0A162ZLP8"/>
    <dbReference type="GeneID" id="28993528"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151177"/>
    <dbReference type="InParanoid" id="A0A162ZLP8"/>
    <dbReference type="OrthoDB" id="443682at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055335">
        <property type="entry name" value="Ucp6/RUP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597:SF1">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="3"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="148"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="585"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="841"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1124"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="409"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="643"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="587"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="851"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1130"/>
            <end position="1143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD67661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1165" mass="131094" checksum="B6E34DC8D8EAFFFF" modified="2016-07-06" version="1">MSTEDYSEAIYQLMDLGITQKQAHKALTRYNFDVARAADYIFSGNADDEEIPVNTTTTASNSQQEPKDWPIWNQEDTAIVQDTHSMDSTRGSAGSTQVLQDSEYEEEPIRPESNKPDQWSVVPFVGPPATPILSSDTAYTPSALTSPLGLCPPSHHFTYAPALFQALFHVPLFRKAILAFRPVPIQWGTPLNYWKGFGDAVSPFTYCSQDPMSDADESDKKKHLQNSQELNTSEEGQSNYDQSQEEREGGINGSGGNSNDDCDDGWPDLNNPDLKSTLEKDIQSMPLSLRVLAEIQKLFAFLSLSKRRYGNVSPVIRALSARMASPHWEFSDKNIDGFLDMLIGCLVETDGLSEKSNESTPSFRDFHECLDPLVYESESTKDDDELSSNSSIAPIKITKEKNTDLDVGNDNAEIEAKDIVEAETEAEAETEAQNEAKTETEITTVSDTTGDQINIKLNTSYKDDNDIDDGQVKCKVTTFEQIPPILIVTLEDRTEETESSDQSDSEESFRLDHTIYLDRYLTANKSHSKEKYQQAEKLRATIAQNKLKKRQLTEITIDNFNKFHTTTILEDTLKYLQAKKDQSHIPTTATDTSNTTASNTHSTYNHNNVNDNDHNSTNTADTTKVSKVIENLKATESAIISAGEFIKKELKDLEANEKELGRKLESLFDENEMKRCRYDLYCTVYNDGQEGKGHTWAYIRVNHTQSEGHWFRFRDASVEPVTAERVERETMTPLMLFYMASTSTANNDNDYDNVSKQEQDQELEHVKEEEKERDCITASDCLSVIPKDLVAFVQEDNAQFEEEIYSISDWQTLERLPISCASTSEGSLVFDDGDSVGTAVGFTPTNRIDDGNNNNNNNNSSSSSSNANSDDDNGEDGNGNGNNNCHIPLSPNSYDELCERRENLVRIANQSTEVDLLQQQDALDHFIDLYWRNPNGPVEEKKARRDDELGWVFAEFDSFVRIGKRVARGLMWFGQGDHRKALQTLVQAKREEEIWKTHLLVDTLGASYHGLETLGFGGPIEQFGKHSLKILNLAAYQKVKHVSYRTRGLEDALWIAHQAHTVIGPERLGTDPVFGQLGEIWYSLTDEIENEQPSAGLTTVQAELLNSLMMAYLDGQTCLINDPEDEREKEEEKDGHTTDKEQAELPIWKMYEQGHRAATKVLIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZP27</accession>
    <name>A0A162ZP27_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">IRG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_150816</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286191.1">
        <property type="nucleotide sequence ID" value="XM_018432551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZP27"/>
    <dbReference type="STRING" id="763407.A0A162ZP27"/>
    <dbReference type="GeneID" id="28993457"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150816"/>
    <dbReference type="InParanoid" id="A0A162ZP27"/>
    <dbReference type="OrthoDB" id="422720at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030385">
        <property type="entry name" value="G_IRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007743">
        <property type="entry name" value="Immunity-related_GTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051515">
        <property type="entry name" value="IRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32341">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32341:SF17">
        <property type="entry name" value="IRG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05049">
        <property type="entry name" value="IIGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51716">
        <property type="entry name" value="G_IRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="IRG-type G" evidence="7">
        <location>
            <begin position="112"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD68151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="350" mass="39318" checksum="DE82791CAA228B95" modified="2016-07-06" version="1">MGQAASKTFSDKSNVLYEHTDLSSRFTKATISTLAVPMVIVAFPLLNAYTFTEEELTGVKVMDGAIGGILGVIGSCWGVFQSVFSQGPLEPLPIPPELKEQAKLRIGLNSDHFYNVAIVGVAGTGKSSLVNGILGYHDSHILAAHTGETESTMRPAGYRHPDLRTMVLWDMPGAGTMHHPAETYFEDNFLCAFDSLIIVTAERLQETDLIIAKKAREWRVPVLFVRNKADQAVDSKMRRDRKEGQEEGRAWAKAVGELTNEASVRQSISTQLKANHMSTRHLFILSAWNLQEFIYRLGQKQLDEHLKIIDEERFVRMLIQGVLTKRKREKKNRQNKDKRMSVPQQIIESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZZF5</accession>
    <name>A0A162ZZF5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Uridine kinase</fullName>
            <ecNumber evidence="8">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_135598</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>cytidine + ATP = CMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>uridine + ATP = UMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the uridine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="8"/>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD70021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288061.1">
        <property type="nucleotide sequence ID" value="XM_018429732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZZF5"/>
    <dbReference type="FunCoup" id="A0A162ZZF5">
        <property type="interactions" value="587"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162ZZF5"/>
    <dbReference type="GeneID" id="28990638"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_135598"/>
    <dbReference type="InParanoid" id="A0A162ZZF5"/>
    <dbReference type="OrthoDB" id="738517at2759"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00579">
        <property type="reaction ID" value="UER00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043771">
        <property type="term" value="F:cytidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044211">
        <property type="term" value="P:CTP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000339">
        <property type="entry name" value="Uridine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000010">
        <property type="entry name" value="Uridine-cytidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004018">
        <property type="entry name" value="PRK05480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00235">
        <property type="entry name" value="udk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="9">
        <location>
            <begin position="29"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="259"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD70021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="464" mass="51556" checksum="616488620F673662" modified="2016-07-06" version="1">MSNKKIHHLGAEGRGPWYNADGLITESYIIGVGGGSASGKTSVSDRILKSLNVPWVVILSMDSFYRVLEPEQIAQAHLNNFDYDHPSAFDFEALYDCISKLKAGKSVNVPVYNFSKHAREKHTTTIYGANVVIFEGIFAFHDKRIRDLMDLKIFVDTDADIRLARRLKRDITERGRDVQGVIDQYTRFVKPSYDDHIRPTVKYADVIIPRGLENTVAIDLLVKHVQLQLQESKLDLRWSLSNIQVGKNLPVNVHVLPVTNQIKGIHTILRDRTTPRDEFVFYAERLTTLIMETGLGLIPFDPIQIKTPTGAVYKGLKVKDKICGVSILRAGGTMEAGLRRVCSDVLIGKILIQADPATGEPQLHYMKLPSNVKDYQVVLMDATIGTGAAGLMAVRVLLDHDVPEENIIFVSFLAAPVGLGVISNAFPRVKIVTSMVDPGLSKDTLFIEPGIGNFGDRYFGTEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163A3U9</accession>
    <name>A0A163A3U9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_170975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288931.1">
        <property type="nucleotide sequence ID" value="XM_018436458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163A3U9"/>
    <dbReference type="GeneID" id="28997364"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170975"/>
    <dbReference type="InParanoid" id="A0A163A3U9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD70891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="450" mass="50511" checksum="1AF115E9B7F20030" modified="2016-07-06" version="1">MFTSKLPIISILQTVLLGYISHVVTIRPRTGVSKFPTGYRRFIALVYPSSGIGLAVESMYKSFFGDKILKISQYKPLLKSYAKEETNKPKKDINRIPLNSSKPASQDSSPLIKPSTLECENDKEIVTKDTRHYTDFSSATCLKDRLLKDMKNKGCGHTEAAYLAAFLHIMGPEKAKQIKHCILNCSITVGVKDEPLNEIMYPYCKTEELVVNGPGAACKYQKKARPDEIHLMTDTMINQLETAHNMDDTSYIEVFVTIGQLFYTTVECMDIDGDRWAKVIIIIYTIMSVLQTSSLLLLHKQIAAFSIYEDRDEALILSLSKEYKASVEGAGSTSSTKNNNSSDKCNHKHDYYDGLVTGLSILAGIIVFVFIGIWADYNSHSLTEWLVLSWILSPIVFCPFLIPYFILYMCAGPFIDIYTYENFLEIPIAFGLFISSGLLLSATIIGYLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163A8A5</accession>
    <name>A0A163A8A5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_170393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289771.1">
        <property type="nucleotide sequence ID" value="XM_018436326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163A8A5"/>
    <dbReference type="GeneID" id="28997232"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170393"/>
    <dbReference type="InParanoid" id="A0A163A8A5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="276" mass="30339" checksum="E02E871E913BB7BC" modified="2016-07-06" version="1">MTSAGPVCASCKQLGHSRRSNLFCPLNPRNKTLLITRKRTSNNLSTQEEYQTESSRAGASRPRVETVQNSVVLTIAEIIALFRADQYPAESSRAAASRPRVEAVQDSVVPTQPMSIDLSFTEQYIAESSRDLTAAFEALQVSAVERVLDLTTTTAITTATVISHCFSCNGIGRLRSNSLQCPNNIRHHTFVPGQLAVTHNMARRTTTPLPPTDNRGAMDVKCQFCGALMWIHGKNYTSKANNIKFSMCCRLGTVILPPFEPTPPGIAELLVWCNQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ARQ2</accession>
    <name>A0A163ARQ2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_166575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293361.1">
        <property type="nucleotide sequence ID" value="XM_018435436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ARQ2"/>
    <dbReference type="STRING" id="763407.A0A163ARQ2"/>
    <dbReference type="GeneID" id="28996342"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166575"/>
    <dbReference type="InParanoid" id="A0A163ARQ2"/>
    <dbReference type="OrthoDB" id="2379842at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22744">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="31599" checksum="18813E1ED619FA0C" modified="2016-07-06" version="1">MAKVNDLINNVSNLKDHPEVAFPLSSQIKASGRPKHSEIRKILKEGLIDVMNELLEEKPLKKTIKNIKKETQFAENKSLSKKLTNILLELKGLTTSQMTTDQIDQAAISLTFNPKSDGWCGFRVFAHLKEGGEDQFPLVTKKMLVTMATHSELYEQNLGMDIAEVTKVIPFGSDIDPAIGKNIPSCPSSMWFSAPDCAQIIAETYNELVFVYSDDRSVLSITFFPLHDQKPLKRKPLPMVLHHVYGCHWTTIKVKPHVHRSLSEIVSLNVLNYCSQKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AV78</accession>
    <name>A0A163AV78_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_166027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294091.1">
        <property type="nucleotide sequence ID" value="XM_018435355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AV78"/>
    <dbReference type="STRING" id="763407.A0A163AV78"/>
    <dbReference type="GeneID" id="28996261"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166027"/>
    <dbReference type="InParanoid" id="A0A163AV78"/>
    <dbReference type="OrthoDB" id="2236419at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="21577" checksum="2D40BAE592F12856" modified="2016-07-06" version="1">MRFRQVDSPYHKKNEEPKDTDMQEATVKKERSSTYNIYTNEDRLRFLFSLHEKLMNPTETTKLANVNPETTRKWKRESAKKTLRRRYPLKKTNRTSNRAPSQLNESYKMYFFNFFDENPSVVIQDVVRILTKGFEDLKIKKSRITEFMKEDCNLSKKVVSRHPKDRNNQTTLEARTNSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AZ66</accession>
    <name>A0A163AZ66_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanosine(18)-2'-O)-methyltransferase TARBP1</fullName>
            <ecNumber evidence="8">2.1.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">TAR RNA-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_109420</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in a subset of tRNA. Selectively mediates Gm18 methylation of tRNAGln-TTG/CTG and tRNASer-TGA/GCT. Gm18 modification can enhance the stability of modified tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(18) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20077"/>
            <dbReference type="Rhea" id="RHEA-COMP:10190"/>
            <dbReference type="Rhea" id="RHEA-COMP:10192"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="EC" id="2.1.1.34"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:20078"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="2.1.1.34" evidence="8"/>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294731.1">
        <property type="nucleotide sequence ID" value="XM_018428115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AZ66"/>
    <dbReference type="STRING" id="763407.A0A163AZ66"/>
    <dbReference type="GeneID" id="28989021"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_109420"/>
    <dbReference type="InParanoid" id="A0A163AZ66"/>
    <dbReference type="OrthoDB" id="241340at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141100">
        <property type="term" value="F:tRNA (guanine(18)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18091">
        <property type="entry name" value="SpoU-like_TRM3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000010">
        <property type="entry name" value="probable methyltransferase TARBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045330">
        <property type="entry name" value="TRM3/TARBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044748">
        <property type="entry name" value="Trm3/TARBP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029:SF11">
        <property type="entry name" value="METHYLTRANSFERASE TARBP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029">
        <property type="entry name" value="RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="11">
        <location>
            <begin position="10"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD76691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="173" mass="19320" checksum="D28A1763B6C2F2EE" modified="2016-07-06" version="1" fragment="single">KKKKRRRNDLIVVASLVDRMPNLAGLCRTCEIFNASQLAVYSLKVIKDPIFTGISVASEKWMPMIEVPEDDVASFLKSKKEEGYVLCGLEQTTTSATLGEFEFPEKCVLLLGKERQGVPANLLQMLDQTIEIPQYGITRSLNVHVSGAICIYEYTKQMQWRQQAPAAVLPGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B1S0</accession>
    <name>A0A163B1S0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Inhibitor of growth protein N-terminal histone-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_164709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295861.1">
        <property type="nucleotide sequence ID" value="XM_018435065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B1S0"/>
    <dbReference type="GeneID" id="28995971"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164709"/>
    <dbReference type="InParanoid" id="A0A163B1S0"/>
    <dbReference type="OrthoDB" id="548474at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038966">
        <property type="entry name" value="TMA17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422:SF1">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="13165" checksum="A05895E0A6217934" modified="2016-07-06" version="1">MQLDQLEKALRQLPHDTLMTEIPEIQNSIAHLKKSNDEMREYDPDHSDPDFVQAIGENIALIKHYEERIDLTLRVIREIIGEAAAREMGSNVASFRERYQTPQESTQEEAGVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BEX6</accession>
    <name>A0A163BEX6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_161783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299191.1">
        <property type="nucleotide sequence ID" value="XM_018434463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BEX6"/>
    <dbReference type="STRING" id="763407.A0A163BEX6"/>
    <dbReference type="GeneID" id="28995369"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161783"/>
    <dbReference type="InParanoid" id="A0A163BEX6"/>
    <dbReference type="OrthoDB" id="2236107at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD81151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="213" mass="23782" checksum="2028D542BA2533F2" modified="2016-07-06" version="1">MSHLQNIAVFVPQVRHKASLPTSTKKRTRIKAADVYWCIDNVVNLSVQTFAITFKHWDYQHCHSHYNTILDSNIPEEHRSRLQDEFETWRKTIDCTELWFNQRHAQALAEAHDNCSEAANNLLISNTQEIKSSVVKYHVPEPAPVTITLQAPTTQVGHTDTSVPPVLPTIGTPVLQSLSPSMTDTLVLTPSQDKLGSSAPASATTSTADIMYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BFH2</accession>
    <name>A0A163BFH2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_72763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299291.1">
        <property type="nucleotide sequence ID" value="XM_018442710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BFH2"/>
    <dbReference type="GeneID" id="29003616"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_72763"/>
    <dbReference type="InParanoid" id="A0A163BFH2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="242" mass="27365" checksum="32C69A76E5AC66AD" modified="2016-07-06" version="1">MSSTIEQNLEECYCTECIKNYNGYILVSKRTVQHHGKKAALKDAIRSELASILNTGAQRHIMNVGVESIVVQKSGSVEVLARQSDLSVLDISPMSVDYEVDVNFNDMNFEYESNGNAKDTVDIDVEEVDTECSYENMFSNSSMPENPVHRFITTFTMQFASRYVVNKGAVVLIKFINELLKIYEQDFQLPTSLPGLQCMMGFLDTMCDVYNVAVWKELKDSNGASFVEQPRLLMLTLNIDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163CY91</accession>
    <name>A0A163CY91_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_74154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441003">
        <property type="protein sequence ID" value="OAD66480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284520.1">
        <property type="nucleotide sequence ID" value="XM_018442993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163CY91"/>
    <dbReference type="GeneID" id="29003899"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_74154"/>
    <dbReference type="InParanoid" id="A0A163CY91"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="199" mass="21778" checksum="6219266F2B8BBB16" modified="2016-07-06" version="1" fragment="single">MGIYSLDLIYLQSPAIQVKHQDSDLPAMGIDLIYLQSPAIQVKHQDSDLPAMGIVLVSGHPGQASRFKSRSTDSGRGPRFQYLFHPGQASKPTSKSTVSVSIPSRVSFKVQVKVSGFRSRSTVSGISKLDEQLLTCFCIFLVSIPSRSSFKVQVKVHGFRSSFKAQVKVNGFQIKVHGFSCIHSIQVKLQGPGQGPRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DJ48</accession>
    <name>A0A163DJ48_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_114298</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289630.1">
        <property type="nucleotide sequence ID" value="XM_018428387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DJ48"/>
    <dbReference type="STRING" id="763407.A0A163DJ48"/>
    <dbReference type="GeneID" id="28989293"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_114298"/>
    <dbReference type="InParanoid" id="A0A163DJ48"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="4">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="3">
        <location>
            <begin position="142"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD71590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="44915" checksum="11E5FC1B42F5FB61" modified="2016-07-06" version="1">MSFIANFLLTYRSFCTSDEFLGLLEQRYNLLAPEGLTPEELETWTERKQKLVRLRVFNVMKNWLENYYTDEDEPILARLEFFTNTVIRDASSFSADQLNRLIRKRRELDPNKNLKKLVPNNAAGPTSIMPKNITDIKMLEIDPLEMARQLSIRDFKLYSSILPIECLGQGWSRDDNDSNAATNVKQSIDYCNRLTAWATESILVHEEPKRRVVIIKYWVQVANHCRILNNYNTCMAILSAFDNSAIGRLRKTWELVGNRTNQTLGYIRKLMGANRNFVEYREMIHSVNPPCIPFLGIYLQDLTFIEDGNPDYLKKSSNLINFAKKQKAAEVIRELKQFQTPPYTFRLIPELQDFIKTRLENSHDIEQLYERSVRLEPRNVEPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DK93</accession>
    <name>A0A163DK93_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHYBLDRAFT_155667</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD71870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289910.1">
        <property type="nucleotide sequence ID" value="XM_018433424.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A163DK93">
        <property type="interactions" value="647"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163DK93"/>
    <dbReference type="GeneID" id="28994330"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_155667"/>
    <dbReference type="InParanoid" id="A0A163DK93"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000007">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.150:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000371">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="HEAT" evidence="12">
        <location>
            <begin position="657"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="FAT" evidence="15">
        <location>
            <begin position="1198"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="14">
        <location>
            <begin position="1932"/>
            <end position="2247"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="16">
        <location>
            <begin position="2252"/>
            <end position="2284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1054"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1055"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1070"/>
            <end position="1083"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAD71870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="2284" mass="260682" checksum="A18C29133FB355EA" modified="2016-07-06" version="1">MASRELSDESHVKFTNDINKRISELSHGSDNNEKLGAIMAIDRLIDLEPEGNVSRFHNYLRNMLPYNDPLVMTPASRVLGRLAVSSSTLTADLVDTQVEHALEWLQSDRSRLAAVLVLRELAVNAPTLIYAYVPRILDLIWVALRDSRQLIREHAADCLSQCLDIVQQRETPMRKTWYARIWEEAQRGLRMNSAEATHGSLLAMRELLLHAGMFMTDMYKEVCEITIKLKDLSNALIRKTVVAIIPTLASYDPATFAELYLDKFMRHLLGHLRKDRDKRDAFITIGQVALQVKSNMGPYLDLTLAGIKETLSVKGRQRKEVETATFTCISMLATAVGQALTKYIYDMLDLMFNCGLSEPLVSALSNIADRINPLATVIQARLLNVISITLSGQPYKQPGAPFSRNIIQTVERPLREGSVTDAKDNDIIVLALKTLGSFDFSNHVLNEFVRDCIVNYLDDDLPEIRKSAAVTCCQLFVRDPICNQTSAHAMKVVGAVLEKLLTVGIADPDPVIRETVLSSLDVRFDRHLAQADNVRSLFIALNDEVFAIRKRTITVIGRLTTYNPAYVMPSLRKTLIQLLTELEYSVVSRQKEEAACLVSLLVRAAQRLTKPYIEPVLKVLLPKARDSSNGVVSAVLGALGELAAVSGKDMVPYLDELMPLIMETLQDQSSSSKRDAALKTLGQLASNTGFVIEPYTKYPALLNILIGILKTEQSASIRRETVKLMGILGALDPYRHKMNAVGSSSEAMADAKLASNDVTLLMMGVGPSSEDYYPQVVMHSLMKILRDPSLSNHHYTVIDAIMYIFKTLGLKVVQFLPLVIPGFLSLIRSCTTSLQEYYFRRLGDLVLIVKQHIRNYLKEIFDLVDDYWTPPSSLQITIISLIEAIAKALDGELKIYLPRLLPHMLQIFDNDTTERRLPTMKVLHAFVVFGSNIEEYMHLVIPAVVKFFEKPDAPVSVRRQAITTITALCKKVIMFDYASRIIHPLARVLPVLPLEARPTAMDLLCALVFQLGTDYTKFIPVINKVLTRHRITHSNYELLVGKLLKGENLPQELGKTLDDRENRGDETPSADLSTAKKQPVNQQHLKKAWEASQRSTKEDWMEWIRRLSVELLKQSPSHALRACVFLASAYTPLARELFNAAFVSCWNELYDQYKEELVHSLEVALKAPNTPPEIIQILLHLAEFMEHDHRVLPIDIRTLAMYAQKCHAYAKALHYKETEFHQDHQPFDAVEMLMSINNLLQQPDAAMGILTFAQDSLKLESKVSWYEKLHRYQDALDAYEKQQIENPTSVEITLGRMRCLHALGEWDQLSSLAQDKWIHAPLENRKSMAPFAAAAAWGLGQWEQMEEYIVLLKLESPDRTFFRAILAMHRNCYSEAEEFINKTRDLLDTELTALLGESYNRAYATVVRVQMLAELEEMIIYKQSSNDAERQNAIRHTWMKRLDGCERNVEVWQRILRVRAMVISPQDDMEMWIKFANLCRKNGRFSLSEKTLCSLMEIDGESTGADPHPKIVYARLKHMWDSASQSTGEDSLTLRTRALSILREFTAQKTQDLGLNPDEMAVSMPIDSARITDDVAEYTRLLSRCYLRQGEWQRGISYELTDETIPDILRSFLLATRFDQNWYKAWHAWALANFDIIDYHERVHPDQIPARIFNHHIVPAVQGFFRSIALSKESSLQDTLRLLTLWFKYGYHPEVSAAIEDGFGTISIDVWLQVIPQLIARVHAPNATVRSLIHNLLTAIGRQHPQALVYSLTVASKSQSEPRKKATHAIMDHMRTHSTTLVDQALMVSQELIRVAILWHEMWHEGLEEASRLYFGDRNVEAMFATLEPLHQMLDRGPETMREESFVQAFGRDLQDAQDWCRQYQETRDLNNLNQAWELYYQVFRRISRQLPQLTSLELQYISPRLLEARNLELCVPGYYRSGEPIVRIAKFNPSLTVIASKQRPRKLTIEGSDGKDYMYLLKGHEDLRQDERVMQLFGLVNTLLKNDAETFKRHLNIERYPAIPLSPNSGLIGWVPDTDTLHTLIRDYRDSRKILLNIEHRLMLQMAPDYDNLTVIQKVEVFQYAFEKTTGQDLYRVLWLKSRNSEVWLDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLHRVTGKVVHIDFGDCFEVAMHREKFPEKIPFRLTRMLVKAMEVSGIEGNFRTTCEHVMRVLRDNKESLMAVLEAFVHDPLINWRLLNNTPVSPQQTRENAQGPEGLNSRAVAVVDRVSNKLTGRDFNPRVTLDVSTQVEKLIQQATSLENLCQCYIGWCAFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DSQ4</accession>
    <name>A0A163DSQ4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_187025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291240.1">
        <property type="nucleotide sequence ID" value="XM_018439317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DSQ4"/>
    <dbReference type="FunCoup" id="A0A163DSQ4">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163DSQ4"/>
    <dbReference type="GeneID" id="29000223"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_187025"/>
    <dbReference type="InParanoid" id="A0A163DSQ4"/>
    <dbReference type="OrthoDB" id="4703at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052416">
        <property type="entry name" value="GTF3C_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD73200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="544" mass="61188" checksum="A28619B5664EA0BA" modified="2016-07-06" version="1">MTSQTLPKKKKLTVERLFRSKTPGSSIETDYEGPAKERLLPDLLDGQYTTYDNVHALATDYKVVSHSEALAYLPEETEPIDVTVGISTKANIKIKTRESVCLDSYMDYKKGFVLNTGCSIWSLDFCPKTPSKDSHPDIHYLAVAGYKSPYPELHSLDLHQPTGSYLNCIQIWRFDLSVKGAQRVPVLDMCLLHDYGVVIDAKWCPYGAYEETVESTDPNVLPKLGILAAAFGDSMPRALVIPHPEAIRALHPKVKDSQTVYMQIREARCVFHAPAIKPTVLSWAGDSRISCGTYSGQIIIWDAKTALKKGLKKDDKAAQSDSIILNTIVHDSAISGLVWRGMVDPVEYISTSLDGYMKICNSKDPFINMTFARSRAIMYKAVWMPQSDNICHNDADNMLHATHTGNTDYFKTGTRFFDSVGKLWDMSTCEPHTFLAASSADGMVRILNVHQLRRKGMQQTQRMVYALLYDKDTNKYTYVDGVRAMECDFNKFLPTRNRFVEAYYLISRVAWNPNRFASPWLASGAVSGLCRVDFTGVGHEWLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DYJ7</accession>
    <name>A0A163DYJ7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminopeptidase P N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_19582</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292250.1">
        <property type="nucleotide sequence ID" value="XM_018439706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DYJ7"/>
    <dbReference type="FunCoup" id="A0A163DYJ7">
        <property type="interactions" value="410"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163DYJ7"/>
    <dbReference type="GeneID" id="29000612"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_19582"/>
    <dbReference type="InParanoid" id="A0A163DYJ7"/>
    <dbReference type="OrthoDB" id="4215474at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="6">
        <location>
            <begin position="89"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD74210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="515" mass="58452" checksum="5CE19D37AB8F3895" modified="2016-07-06" version="1">MFCRRSRLARSALVSRPQLIGANHSHVQRPTILHCALKKNTGATHPAYRTFTTVPTSNPIPDTHKRSFGQPTVHTHPYLINKNDLTPGIPKTEYELRRTILMSSLPKGSTVVSVGYKTRYMTNNIFYQFHQNTDFWYLSGFNEPDSAMILRKGYKQIMFVPPKSAHAELWDGPRTGVEGAKEIFGADEAYDNSRFTSFLKDAMNADHLFIDSPSVNPSLLERVSPEMSFNSLFLYLVAKFRKALKPLSILIQELRIIKSDNEIDIMKKSGQISSKAFIQAMKWTQPEFSEAQLWAKLDYECRMRGSSMLAYIPVVAGGPNALSLHYVRNDMKLRDGDLVLVDCGGEYNGYASDITRTWPVNGKFTEPQREIYQAVLNVNKACIKMCTENAKLSLHAIHTESMKLMKRELDAIGFSVTNSDLENMLYPHHVGHYLGLDVHDLHDITRSRRLKKNMVITIEPGLYIPYDKKFPSKYHGIGVRIEDNVVIGEETPYVLTATAPKEVIDIEYCCKSTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EPP6</accession>
    <name>A0A163EPP6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1688-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_176535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298720.1">
        <property type="nucleotide sequence ID" value="XM_018437796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EPP6"/>
    <dbReference type="STRING" id="763407.A0A163EPP6"/>
    <dbReference type="GeneID" id="28998702"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176535"/>
    <dbReference type="InParanoid" id="A0A163EPP6"/>
    <dbReference type="OrthoDB" id="2153176at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012469">
        <property type="entry name" value="DUF1688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687:SF3">
        <property type="entry name" value="PROTEIN URG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07958">
        <property type="entry name" value="DUF1688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="47424" checksum="16E404C3FD13CEDE" modified="2016-07-06" version="1">MTVLPQNYLRTLDSIRDRCGQVYEKGQKDQLDFFDVDDSKLPQIVDHVASLTQRRFPDLSKIPPHSRLRHFGINDGLDRLQNIRETRWKKLDKIESARRLIDLVIASVLVDAGAGQTWKYKAKDGELIGRSEGLAVASFDMFEEGYFSSSKEVPDRVDVEGLAQLSIERMTQGFQVTSANTMVGLEGRSNLLKGLSKVLEQQKKFFPTVDGQPRRPGNLVDYLLANVEEDDNGKKSVSIEKLWEVIMSLADVWPARVTIEGVKLGDVWPCSCLEDKGNYENLVPFHKLSQWLTYSLVEAIESSIDLTIKGTEKMTGLPEYRNGGLLVDYGLLKLKPAQVKRGTSEGQELPTFEGSDSLIVEWRALTVIYLDKIHKAVEKKLGQDLVLAQVLEGGTWTAGREIAATLRPDTAGPPIVMESDGTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JCG0</accession>
    <name>A0A167JCG0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_153185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441008">
        <property type="protein sequence ID" value="OAD65708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283748.1">
        <property type="nucleotide sequence ID" value="XM_018433088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JCG0"/>
    <dbReference type="GeneID" id="28993994"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153185"/>
    <dbReference type="InParanoid" id="A0A167JCG0"/>
    <dbReference type="OrthoDB" id="2285602at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="227" mass="25835" checksum="70493BFDD76BE573" modified="2016-07-06" version="1">MNKNNEAVLVNVVYTPQLSEIQTTQSRTDTAIANEPVRVTSQEHNRHQALYLLFPFKYYSYTSARNRNANKVDRFDLRYQPRQLRSKFQYPSTYLFCRAPSIFANGMWSQPYSIFTLYEAPDTGHESAAKIASKLFLSIAETVQSNTHPTLPKTFVNTLLTKCQDGQVKSILQQIVELYHGENAVDILENHFLNEKLMSLANLMSASLVSANKSVAENVKSRVLNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JCN2</accession>
    <name>A0A167JCN2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_34470</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Lipid-anchor</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441008">
        <property type="protein sequence ID" value="OAD65726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283766.1">
        <property type="nucleotide sequence ID" value="XM_018440033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JCN2"/>
    <dbReference type="FunCoup" id="A0A167JCN2">
        <property type="interactions" value="629"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167JCN2"/>
    <dbReference type="GeneID" id="29000939"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_34470"/>
    <dbReference type="InParanoid" id="A0A167JCN2"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01874">
        <property type="entry name" value="Cdc42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000236">
        <property type="entry name" value="Cell division control protein 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037874">
        <property type="entry name" value="Cdc42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD65726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="191" mass="21280" checksum="76B9F2AD1B4C20DD" modified="2016-07-06" version="1">MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGDEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVTSPASFENVKEKWFPEVHHHCPGVPCLIVGTQIDLRDDPTVLEKLTRQKQRPIGFEAGERLARELGAVKYVECSALTQKGLKNVFDEAIVAALEPPVKKKSKKCFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JJT4</accession>
    <name>A0A167JJT4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_34708</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441005">
        <property type="protein sequence ID" value="OAD66137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284177.1">
        <property type="nucleotide sequence ID" value="XM_018440037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JJT4"/>
    <dbReference type="FunCoup" id="A0A167JJT4">
        <property type="interactions" value="616"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167JJT4"/>
    <dbReference type="GeneID" id="29000943"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_34708"/>
    <dbReference type="InParanoid" id="A0A167JJT4"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03275">
        <property type="entry name" value="ABC_SMC1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028468">
        <property type="entry name" value="Smc1_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="12">
        <location>
            <begin position="519"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="400"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="676"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="818"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1024"/>
            <end position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD66137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1228" mass="141424" checksum="3439CAB8B762ECC0" modified="2016-07-06" version="1">MGKLVRIEVENFKSYKGNQVIGPFHKFTSVIGPNGSGKSNLMDAISFVLGVHAVHLRSQNLKDMIYRSSALREDDNTPSTIRSPRRAHVLAVYENDHGHEIKFMRIVNSNGQSEYRLNDRQVSYADYNKALEKENILVKAKNFLVFQGDVESVASQNPKDLTRLIEQISGSWDFKEEYETLQKEQERAIENSAHAFNKKRGVSSEIKQYQEQKTEAERFEALVDERKQLVVQYLLWKLFHVEQKIHVLEADAEKKKISAEGATEDQLKLEDQFKMARKEQASIHMERTRRELQIKKINNDLNELRPATIGMDEKAIHLQKRLEQTKTNGERVKRDHDKQLEVVKGLEQDLENLNIESTSYEGKFITNRTKQQLFLSEFCLKQIIKLISQFAKYRYSPIEAVEEQQQLHNLQRQRKMELEDVERKRSKLEENKTRLAQLAEDSRQITEDGTILTGDLQALTKQLTIRKQEANALVREQVELNERLQVTLNKLLEVNADRRESEKERRANESLAMMKQIFPGVHGKLVDLCRPTQRKYEEAVATTMGKTMESIVVDDQKTAMECIQYMREQRVGTATFLPLNGLSVPSINDRFRNYTRGARLAFDVIQYDKQYESVVQYACGNTLVCDTIAIAKNICYEKNEDVKAVTLDGTVIHRSGLMTGGQTSSQRSSRWSERDVEDLMRTRDKLMAELNELSKQKRMGSAEEQAKSDCAGLQTQLEVLQEEITAAEHRLMDVNREAQHLQTNIANSEPLLEKAKKDLETINISIEQVEDRLAVIEDRIFSGFCSSIGVRTIREYESLQFGLSEKIVERRAQFSAQRSRLETQLSFEREQLGDLAERLIKLETLFTQDTEALAQLELAREDLNKKIREFTVDLSKFTTELKEQTQLEDEKQRNIEQLRRDLESKGQDVNGYLKEMAKFETEVEKVHAERVSIFRKCKLEEIVLPLLRGNMEDLLVDEVATQSSDSMDVDQPSQRSIRSSDWEVAIDFSPLGSEQRNNGDSRLEREFQAEIKERSIQIDQMAPNLKAIARLEGVEQRLQDAEDAFDTARTITKQAKEKFNTVKQKRYKAFYDAFSHISEQIDRVYKDLTKSATFPLGGVAYLSLEDSDEPYLEGIKYHAMPPMKRFRDMELLSGGEKSVAALALLLAIHSYRPSPFFVLDEVDAALDNTNVAMVANYICQHASDSFQFIVISLKNTLYEKADSLVGIYRDQEANSSKTLTLKLDQYQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JQW1</accession>
    <name>A0A167JQW1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_160584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441002">
        <property type="protein sequence ID" value="OAD66519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284559.1">
        <property type="nucleotide sequence ID" value="XM_018434209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JQW1"/>
    <dbReference type="GeneID" id="28995115"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160584"/>
    <dbReference type="InParanoid" id="A0A167JQW1"/>
    <dbReference type="OrthoDB" id="2094832at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="84" mass="9798" checksum="CF90B3C6E70D9F40" modified="2016-07-06" version="1">MKYASVIGDSIIRFYADYVGIKDRNELTTHLKRVQALLNEVCLLTSCIYVYTTTSLEQPNLQVYRRIQICLLSYVRPVLLPWVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JUN4</accession>
    <name>A0A167JUN4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_152289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441001">
        <property type="protein sequence ID" value="OAD66739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284779.1">
        <property type="nucleotide sequence ID" value="XM_018432880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JUN4"/>
    <dbReference type="GeneID" id="28993786"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152289"/>
    <dbReference type="InParanoid" id="A0A167JUN4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="394" mass="43868" checksum="D93E58908583EEB3" modified="2016-07-06" version="1">MTHVMLHGQHGPYGLFRQSQAIKNRFPSRATGTPRLEEHMLIVFCMLLVPSVQVKHQGSDQSPWLSVSIPSRSSFKVQVKVHGFQIKIHVSNSIQVKHQGSDQGQRVQVEVHGFQYPFHPGKASMFRSPRYVSAIQVKCQGPDFPAMAIDVRRQGCDLPVKCSVIQVNQQDSDLPSMVIAIDVRRQGSDFPAMVLVIQVKHHGSDRPSMVIAIRGKHQGPDHPSMPPAIQIKRQGPDHPSMFIVIQIKHQGFDRQPMVISYSAIHVKRQGSDRPSMVIIVQVKHQGSGLPAMSPAIQIKHQDSDLPAMGIVSSYPGQASRFRSPRHGSSLRPSRSNFKVLISRYMVIGITKIDEQSHSALFISSVESTKIMLHGSGFMSTHPRQLSGSDFHELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K2Q4</accession>
    <name>A0A167K2Q4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_151745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441025">
        <property type="protein sequence ID" value="OAD67139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285179.1">
        <property type="nucleotide sequence ID" value="XM_018432739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K2Q4"/>
    <dbReference type="GeneID" id="28993645"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151745"/>
    <dbReference type="InParanoid" id="A0A167K2Q4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="40159" checksum="BD3A73A403802C6D" modified="2016-07-06" version="1">MTKRIPTAPRRPNLCMNAVLNSTIAGVVAPIDTPTPEVAVNTAPEVQVAVTPMDHVLTLLAANNVSMQSLQENAKGVTDAITHLKNGLDLSNKTNEFLKNSVLQLMTENAEIKKAMTSQNSVMPSAVPADSSSSMDDDLVLGAKHHPLISQLINSYIKKPNFVSTDPLKVAENNNRSAWSMTGTYGDKYNKTLALALFKYLRPQRCCTNVSKSVIMNIIKNHYQNQVRVFRTSAEKIMVRNKAGRRRNRKKTLLDRRIITYQTYTEAIHEGMNRYDCGNILSIDVMSDGESDGNNKVRAYRPSWRTDELQTFISTIDELTVIRLKKNSESLKKRIPYEKEVSIPENLAVTLPDWCFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K9T0</accession>
    <name>A0A167K9T0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_174248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285598.1">
        <property type="nucleotide sequence ID" value="XM_018437216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K9T0"/>
    <dbReference type="GeneID" id="28998122"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174248"/>
    <dbReference type="InParanoid" id="A0A167K9T0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="110" mass="12559" checksum="D8CF83C02EAC4B21" modified="2016-07-06" version="1">MTGEVVSVKVRKHREKKTYTKAINTAGKKEYSSYCSKHEDIMLVHALFFAVVFKSVNNKIVISNILIVIAFSTIKVTNATIVTTFVMSPVFYTNLYTVKCWLKIFSRKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KRD5</accession>
    <name>A0A167KRD5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_160106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286737.1">
        <property type="nucleotide sequence ID" value="XM_018434117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KRD5"/>
    <dbReference type="GeneID" id="28995023"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160106"/>
    <dbReference type="InParanoid" id="A0A167KRD5"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="234" mass="26838" checksum="A85A67916C45E6B3" modified="2016-07-06" version="1">MKPIQFYDLALKGLGEVPWSPNTYKTRFTLNIKELSYVTTWLSIDEIHTVIPKVTNTGETPTVPVIVDTEKDQVIQDSFKIAKYLEATYPQTPSLFHGNEQLHTSMQETFDTRLLRHLFCLSVLAIYRNCGDESMQAEFRKNKEQKFGVTLEQFAGNPEDHIKEIGNILKDTKNTLTETLYLTGSKVGWADVVLASYLKMVDVLNHDVFESGILGSKEAEDSLRKWYERMSRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L1A0</accession>
    <name>A0A167L1A0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_188451</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATG22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287399.1">
        <property type="nucleotide sequence ID" value="XM_018439509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L1A0"/>
    <dbReference type="FunCoup" id="A0A167L1A0">
        <property type="interactions" value="5"/>
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    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_188451"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Atg22"/>
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        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <keyword evidence="4 9" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="497"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="329"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        </source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OAD69359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="551" mass="61432" checksum="BD9220B192D40F80" modified="2016-07-06" version="1" fragment="single">MKQATGFFDSPFNSTDADIDPTSDTAKEVLKQPPATKYELWGYYLYYNGDNGFTINSYMPNIFQYLAYKGGFYSDTPDIKGCDTNDALRQCNIHWMGKPGGIPIASMLLYVQAIAFSLQFLLFTTFGSLADYGRWNRYILLGATVIGCAAQIIPITLVNDDGSHWNAMMGIMIIALISYGTSLVFYAAAFPTLSDNLPAVRKAKADPNLSKDEKLQVTELWRNHVSAVSTVWSNVGFLIMTGVLSGASFKSWENYDFPEDVSHVLGNVPLFNFISTVVCGGFWIINAIPYFIAQPSGRRGGELPEGTNHLTVGWKSIILALKEARKLRYLFMYIISYFMFSDAVSTTNQMIGIIQGEITNFSAQQVTILNLASAVTSIIGCLFFLWIAKRFKVRTKTNLLIIIGLSGLVAVWGCFGIGIDNFGIKTNWELWVFYVWTGLFTAPIWAWQNTMLAELVPKGKENLFFGLFGIVNKASSWIGPVVIGAITEHTDNLWKGWPFVLALFVISIVLVYFIDVDKAKLEMITYIEENPEPSSITETPSTSVNEKTQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L887</accession>
    <name>A0A167L887_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_171826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OAD69808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018436674.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28997580"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171826"/>
    <dbReference type="InParanoid" id="A0A167L887"/>
    <dbReference type="OrthoDB" id="2242038at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="477" mass="55277" checksum="D1B68AF6CB49D1A7" modified="2016-07-06" version="1">MGTTCGPRESKCSLSPENVGSQISKYDLQKSVYSIKKSVRKLARPKAQRLSFKIYLEQLNPGIFMKTVIDCDEDEESYLELLNHIEDTQSLPISVYMVKDDLRVLRSRSITKFGILIKNRFYAWTCIETGRRVAQDKALNDNHKLLLESKVIIINLINSFSLINPTSITIVIFANLWIFDVKLMINENDNRRTLFEKKIGRCQIFLERCGELIVLKRQEENMGALWSRELTSLYCCDDLAKAKKEISSLTLLLSVEEGGHHNISNMEFLEQLLTDVLYKSDGLIKLFGLKKLELALLETSGHFTNSDKVKIKLDHHKGMYGVLSMLKCVADDFSFASVDKLSPVKVFFYSCRRLHLWSVRYQDGLYDFWREHCLEIRPDFEDRAMFVPRLIEFCWNVKYLLENAVEDIIKVKKDHQINSAKYRYNPQECTQLSAIVNPIILKLTKEDDGEGIGKLGPIFIIARRVVTERTLKIRYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L8N6</accession>
    <name>A0A167L8N6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Attractin/MKLN-like beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_182641</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287879.1">
        <property type="nucleotide sequence ID" value="XM_018438652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L8N6"/>
    <dbReference type="STRING" id="763407.A0A167L8N6"/>
    <dbReference type="GeneID" id="28999558"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_182641"/>
    <dbReference type="InParanoid" id="A0A167L8N6"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244">
        <property type="entry name" value="KELCH REPEAT DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007889751" description="Attractin/MKLN-like beta-propeller domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Attractin/MKLN-like beta-propeller" evidence="6">
        <location>
            <begin position="115"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="450"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="547"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="613"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="456"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="471"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="488"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="613"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD69839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="639" mass="70882" checksum="6A4FADAB5BD46E01" modified="2016-07-06" version="1">MIPLSIILVAFLQLTSLGLGQPIKTNEPRIHHTLVRLPNNTIVSIGGFSTLDQTFVDTQTHLDTLQTHRDQSIAGHTSHWYPPTQSIVSLFGLHGPGIQTRDERRLADRHRNSYTSTLPVSRYGHTSTLLGKDLYVHGGFSINADQLVPLSDLWLFRWRSKTWTQPSLHTQNNQRIPIAGHTTVNYQNWLLSCFGITKNNELMSHCTCYDTITSTVHTILEASLPKPRTMATMTTFPFDPSRAILFGGMGSEGLLLSDAWEIDMSQLPAHISWRKLAQGQPRAGHAAVFTDDSIVLFHGGLDESNQLTEKSLEFDTNTFTWVLSPGVFRQQLIKRADESNAGKIAGIAVGCVAGVIIIGGCLFMVWYRRRQAKSVQDKASHNPRFSYALSGSNQRRSAASEVSTVLQAPAVAIRSSRLTPMNRTSELFPSIAETSGIIPIHFPSVAEYSERHNNQHQHQQQHHQQQQQQQYQKSRSTPNITKTNSIISDTPSVKSTSSSPSMGPSIAFTPARINNRLSERPTSDALWMQAILNNSLIWKDESETNQAAAQVSVPPSPRLLQPPLTPTSPAFPRRPSSDSHKSVSSIQWVGFNEGMDYRWYPGLQVTNLRKSQLSLSTNSNPGTPTFPPADSSGSSIHHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L9N4</accession>
    <name>A0A167L9N4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_135540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287949.1">
        <property type="nucleotide sequence ID" value="XM_018429729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L9N4"/>
    <dbReference type="FunCoup" id="A0A167L9N4">
        <property type="interactions" value="299"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167L9N4"/>
    <dbReference type="GeneID" id="28990635"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_135540"/>
    <dbReference type="InParanoid" id="A0A167L9N4"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD69909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="41730" checksum="EED4224813CFB012" modified="2016-07-06" version="1">MEDEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLRYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKSNREKMTQIMFETFNAPAFYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDMAGRDLTDYLMRILAERGHSFTTSAEREIVRDIKEKLCYVALDFEQELQTAAQSSALEKSYELPDGQVITVGNERFRAPEALFQPSMLGLESVGIQDTTYNSIMKCDVDIRKDLYSNIVMSGGTTMYPGIADRMQKEITALAPSSMKIKIVAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LDW2</accession>
    <name>A0A167LDW2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_60139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288277.1">
        <property type="nucleotide sequence ID" value="XM_018440603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LDW2"/>
    <dbReference type="GeneID" id="29001509"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_60139"/>
    <dbReference type="InParanoid" id="A0A167LDW2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="115" mass="13248" checksum="A28226950D0DCF10" modified="2016-07-06" version="1">MSLNSGRWEYLSAWSRISEALIPNNYVAIHPFTGDPFEITESAIWLSQIRKLTQSNVQIGHCTKRQLGCSKARAGFKKRHLAPEVLIGFLFSFYRRTLKLLVPQAFINSNYFIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LFS7</accession>
    <name>A0A167LFS7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_115437</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288398.1">
        <property type="nucleotide sequence ID" value="XM_018428463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LFS7"/>
    <dbReference type="FunCoup" id="A0A167LFS7">
        <property type="interactions" value="556"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167LFS7"/>
    <dbReference type="GeneID" id="28989369"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_115437"/>
    <dbReference type="InParanoid" id="A0A167LFS7"/>
    <dbReference type="OrthoDB" id="308861at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09839">
        <property type="entry name" value="M1_like_TAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000011">
        <property type="entry name" value="Transcription initiation factor TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057345">
        <property type="entry name" value="Ig-like_TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057991">
        <property type="entry name" value="TPR_TAF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25316">
        <property type="entry name" value="TAF2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25577">
        <property type="entry name" value="TPR_TAF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 Ig-like" evidence="9">
        <location>
            <begin position="435"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 TPR repeats" evidence="10">
        <location>
            <begin position="615"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD70358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="849" mass="95804" checksum="84053EBB6B8A235B" modified="2016-07-06" version="1">MCVCHLELQDDVTIAEKAPTAPTAVPAPSFAPLVIRVDYILDHPKAGVVFVEPDDERHSHIYTVNQPLPGATRAWLPCIDKISERCTWEMEFVVPRRMSGVTGEYDTEGVFEEEEDATVVVCSGDVVEQVVHPLDPSKKIVHYSLSVPTAAPFIGFAIGPFEMIKLSPSQLQEEVLNAADLDENQQQSLMAEINMMSNIYAFALPGKEEELSVSCSFLMHAMHFYAQEYGSYPFSDFKMVFVEDAWNETASCASLAICSSHLLHPADIIDQTYHTRQALSLALARQWFGIHITQKSWPDTWLVCGLANLISSLFIKRHLGNNEYRLRLKRDMELCCALDVNRPPLYNPALPSPLDPEDLDFLELKAPLVLYMLDKRMCKGGGTLGLSRVLPKILVSAMSGELVQNAISTHYFMKLCRKVSGFDTKTFADQWVYKSGCPKFGFNFHFNRKKMVVEIFMRQENTNTVIGTGENSTSLTADGGAINFQELVTPLFTGNLTVRIHEADGTPYEHILDIQSSKHKFEVQFNTKYKRIRRNTKQENENEDGDGTTNVLGIIPSLGLGMPIFEDPQQRQDWKIIEWGQDEEDTSGAASAMFDWIRLDAEFEWLSVFEFQQPDYMWAAQLTKDRDVVAQHDAIGALRHMPSLPTSTSLLRALLDPKCFYKIRMEAAYALATCAIPSLDYTGLHQLNKMFQKRYCFPTGNSLMEIDDEIPLSLAIPKPNNFSTLPDYFIQKAVVIAFSQVRDQHGLAPIKIRQFLLDLLKYNDNISNEFSDCYYVATLISAVGDSVIPSPDVPDALQFDDIEGEQLLTAVKAEIERFRTLDYVIPTYHNVVTVACIKVSFISFFVEHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LKX2</accession>
    <name>A0A167LKX2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_148586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288709.1">
        <property type="nucleotide sequence ID" value="XM_018432112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LKX2"/>
    <dbReference type="GeneID" id="28993018"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148586"/>
    <dbReference type="InParanoid" id="A0A167LKX2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="133" mass="14555" checksum="4E7656E14B4C9DED" modified="2016-07-06" version="1">MTPSSLPPHYAAQSPPGRKPDLVAKEVLEWWQTNGKHPFIQPHISSPSNVGANSPENLPLGDDKVQLIRLPVASPSAVKEFSQVSSEEPAHLTTETMPHDFSELTELASNNFHFPMLVAWKNLPATVARDASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LPK4</accession>
    <name>A0A167LPK4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HotDog ACOT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_148073</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288894.1">
        <property type="nucleotide sequence ID" value="XM_018432005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LPK4"/>
    <dbReference type="STRING" id="763407.A0A167LPK4"/>
    <dbReference type="GeneID" id="28992911"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148073"/>
    <dbReference type="InParanoid" id="A0A167LPK4"/>
    <dbReference type="OrthoDB" id="331699at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655:SF0">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="298"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD70854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="461" mass="53202" checksum="D49CB79C7AE21813" modified="2016-07-06" version="1">MVDPRSQTRLIPRVYVNIPDRNTPDEAWKRLTVPSKNPDFIYTSKRIPERDYKIHNDIREYAIEYRKNPQMSKTMSSSYLERFIPFKSSIKCYEEYSSPNKNIRFGKLLEEIDDIGGSITGRHIECLRSSDICFPITAGVEQIYSNMPDTIEDYKLCGHVAYTRNALMVVYISLEIVRHKAVMSTRIMAPKVIPKLGVWNKNTVAVFSATFLQYNTMTGRSEPVGQLIYSTPQEKQMYDQMAARHILKQNHLKQANRILLLAEQNKYNNSITSTGVKDHPNFSSDLDKNTLFETVYISSTKIENTFTANPQYRNCNGKVFGGYIIRDSYEFSCTGVTYFLRSSQFRLIKINDIIFRSPMMAGDHIRMTFEVICSNGPQGADLITCTTTETRNPNTLEYKVAVMMYTTFVSRDPSVKVKMVLPETNKEKHFWSIGHELIQQKNECYLEFVGKTDESEKMAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LQU1</accession>
    <name>A0A167LQU1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_114838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288964.1">
        <property type="nucleotide sequence ID" value="XM_018428418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LQU1"/>
    <dbReference type="GeneID" id="28989324"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_114838"/>
    <dbReference type="InParanoid" id="A0A167LQU1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="55" mass="6626" checksum="60E5898DF7495930" modified="2016-07-06" version="1" fragment="single">KQWETVIWSDKLSFMLYKKNSSRKLWCKTSERFGTNHFVPKVRGNDKMVMVWGCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LRV3</accession>
    <name>A0A167LRV3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_148182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289006.1">
        <property type="nucleotide sequence ID" value="XM_018432031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LRV3"/>
    <dbReference type="STRING" id="763407.A0A167LRV3"/>
    <dbReference type="GeneID" id="28992937"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148182"/>
    <dbReference type="InParanoid" id="A0A167LRV3"/>
    <dbReference type="OrthoDB" id="3875004at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="63" mass="6847" checksum="37640728AD12EE0A" modified="2016-07-06" version="1">MSSACDSSLLRISIIMRNTFSIVSSMDSDLEAFSHYPANGSFAALAFQPAANTNYLNEGFLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LW18</accession>
    <name>A0A167LW18_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_147712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289247.1">
        <property type="nucleotide sequence ID" value="XM_018431932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LW18"/>
    <dbReference type="GeneID" id="28992838"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_147712"/>
    <dbReference type="InParanoid" id="A0A167LW18"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="98" mass="10965" checksum="262A0920F5899DB7" modified="2016-07-06" version="1">MFAQTSSKFNSTSSVPAKRQRSYSQESINISTESSKSSNDCFMDIDSGNRSLGEFHIALCNLGEETDEDDDDIDILLDPSQLDVESQFVYEMCNISTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M2W7</accession>
    <name>A0A167M2W7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_147352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289647.1">
        <property type="nucleotide sequence ID" value="XM_018431847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M2W7"/>
    <dbReference type="GeneID" id="28992753"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_147352"/>
    <dbReference type="InParanoid" id="A0A167M2W7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="85" mass="9564" checksum="9E43D5A5F583D9F0" modified="2016-07-06" version="1">MSHLPGVLFFWKDPERPIDMILLQSDQSKSFVLLSDSAVINTHSQQVGLVMSDATDSTTTTTTKYTVWPELNHGPKLNLGQYRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M7V9</accession>
    <name>A0A167M7V9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_68671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290099.1">
        <property type="nucleotide sequence ID" value="XM_018441986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M7V9"/>
    <dbReference type="STRING" id="763407.A0A167M7V9"/>
    <dbReference type="GeneID" id="29002892"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_68671"/>
    <dbReference type="InParanoid" id="A0A167M7V9"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="281" mass="31626" checksum="32B735E8F59F98A5" modified="2016-07-06" version="1">MSLKRLHREEDTFNKSDNGNVSNSGDKTDYGNSDSDSDSDSNSDSDSDSSQSAKRARHTPSPLIHLPCEVLTKIFILSSNPQLPLVCRSISYMLYHCSNGIKLEWLMHRHKYSIQKALQASLNFPFVNPDLIFRFYYLYQQQNNDINNVTLLTDVMIPTRLFSDAKPEDECLELTRLLLERGASPTKPKGYPVIKASQVGRLSMVKLLVAFGADPTVRQNMALRVSAARDNREIVSYFLDDLKVAPDSETLKACVQKGLWDMVTILMNHGAVPDMTTVNYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M8P0</accession>
    <name>A0A167M8P0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_71276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290177.1">
        <property type="nucleotide sequence ID" value="XM_018442436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M8P0"/>
    <dbReference type="GeneID" id="29003342"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71276"/>
    <dbReference type="InParanoid" id="A0A167M8P0"/>
    <dbReference type="OrthoDB" id="2224690at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="133" mass="15447" checksum="E6DFE8DBD7402C6F" modified="2016-07-06" version="1">MEIGLQTNQVSDFAVYGMEYPKKNYKHLIKQKIGELYILDINAFNMSKVCDFCNSKYFRYFQDASGRPNHPILACNNCIFFCNRDVMAAKNMFYIVQEIWGGNGELKDAYSAIHRVFQFVYFAYTIKTGTLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MIR4</accession>
    <name>A0A167MIR4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hydantoinase B/oxoprolinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_134077</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290986.1">
        <property type="nucleotide sequence ID" value="XM_018429616.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A167MIR4">
        <property type="interactions" value="111"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167MIR4"/>
    <dbReference type="GeneID" id="28990522"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_134077"/>
    <dbReference type="InParanoid" id="A0A167MIR4"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="247"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="5">
        <location>
            <begin position="560"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="751"/>
            <end position="1281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD72946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1318" mass="142530" checksum="30AF2CC2F7AE5295" modified="2016-07-06" version="1">MSKIHQNEKLTICIDRGGTFTDCIGFVGRPGEAGYREFVVKLLSEDPNNYKDAPTEGIRRIVQLATGQTISRSQPVPTQSIESVRMGTTVATNALLERKGERCALLITKGFKDLLIIGNQARPKIFDLSITKPDVLQQDVVEIEERVVLLNSAASQETVKDPHTLSDVVKGISGEWLKVLQKPDINLVKAQLKNLYDDGYKSIAVCLMHAYTFPEHEKKIGEIAKSIGFTHISLSSDIMPMVKIVPRGTSAVADAYLTPCIQGYIKGFVSGFDDGFEKGTTKLQFMQSDGGLVPVNNFSGFRAILSGPAGGVVGYAQTTFDSKDKTPVIGFDMGGTSTDVSRYDGHYEHVFETTTAGVTIQAPQLDINTVAAGGGSMLFFKNGMFTVGPESAGAHPGPACYRKGGPLAVSDANLLLGRLLPDYFPKIFGPNEDLGLDINIVREKFAELAKEINKTTGEIKSLDEVVYGFIKVANETMCRPIRALTEAKGHDTSKHILAVFGGAGGQHACGIARNLGISQIVLYRHSSILSAFGLALADVVHEVQEPSAEGFDSSSLPRIKTRVETLVKQCTDKLLQQGFDASEISTEVYLNLRYDGTDCALMTLKPLSPTDWDFEGEFVKLYKQEFGFSLPERIICVDDIRIRGIGKSFPSKELTPREEIERRKSSQNSDVKALEESITSVYFESGRDENVPVYLLHKLPAGSLVHGPAVIIDATATVVIEPACKALITSQHITITVGEGEKKKVTTEMEPIQLSIFSHRFMSIAEQMGRTLQKTAISTNIKERLDFSCALFGADGGLVANAPHIPVHLGALSHAVIYQMNYYKEDLQEGDVIMTNHPAAGGSHLPDITIITPVFDRGKIVFFVASRGHHADIGGISPGSMPPHSKELYQEGAAIKSFKIVSNGKFDTKGVEHRLCDIPASYPGCSGTRCLRDNISDLKAQIAANQKGIILVKALIEEYSLEVVQAYMLHIRRNAEQAVRHLLKQVAKDHQGHDLVAVEHMDDGTPICLRVTIDADDGKAIFDFEGTGPEVYGNTNAPESVCHSAIIYCIRCLVGQDIPLNSGCLEPIDIRIPKLSILSPSETSAVVGGNVLTSQRTVDVVLKAFEACAASQGCCNNLTFGKGGKNAETGKTTSGWGYYETIAGGSGAGPGWEGKSGVHTHMTNTRITDPEILERRYPVILREFSIRKGSGGKGLYNGGDGVIRDIEFIEPDIQVSILSERRVFHPYGLLGGEDGKTGLNLWIQSSDGKEHPVNLSGKNSALFGKGDRIIIQSPGGGGYGNQHHSSPGIVQKAAKTLSNFVIKAGGSLGAYKDTSESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MZF3</accession>
    <name>A0A167MZF3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_167993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292629.1">
        <property type="nucleotide sequence ID" value="XM_018435777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MZF3"/>
    <dbReference type="GeneID" id="28996683"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167993"/>
    <dbReference type="InParanoid" id="A0A167MZF3"/>
    <dbReference type="OrthoDB" id="2289615at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="311" mass="35734" checksum="25052F8146BA17B9" modified="2016-07-06" version="1">MSANNHGLIGMINCRKKKPDKYFCTFCKVYSNSQKYRVNAHEKTCKQKNLIQNYPLEHSASDPFKSLLEVAFMAFFHASCMNFSEQKIKSILVMMNIAFGLKEKSPNLKISATNSILNYNNRKRSCIHSITPTVHVGHNKKNQEHQFFMNKPSMYLKYLMDDPNKNPLLSSLPDKSTSELNCLQEDEKWQTHKINDIWARHLVKLNCMNFEANHLLTTQFFKQKKTPSSDISVESESYVSYAEDYLVKKDLSVPLLGFVLKVEKSDGTLMKAVLTSLILFTDDTSGNLSKQYNLFGSYLMTLTAMSYDCCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N6Q8</accession>
    <name>A0A167N6Q8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_167478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293199.1">
        <property type="nucleotide sequence ID" value="XM_018435647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N6Q8"/>
    <dbReference type="GeneID" id="28996553"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167478"/>
    <dbReference type="InParanoid" id="A0A167N6Q8"/>
    <dbReference type="OrthoDB" id="4327540at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="30658" checksum="5DB4CEA34DE0FA18" modified="2016-07-06" version="1">MKDKENWVNMYVYKHAHFGNRMSNRAESAHASLKHSLGTSSGKLKTVTLKVKKWYDELVADRKHRLMVESLGEGTKIVFNKVNATRLNDIRLKVCRFAMDQIKLELSKSIIPEKLAKECKCLIQYNYLLPCYHTLAKFDTIPISCIPRRWRKNYLEGENHLTIQNATPVPPNINNIKPITPEFNYALELICEHFANAQSEQEQINIYQLIEKTLKQIDAQKLENLKGPTVVEAIKGRPKKYQAQDDCIRALHQYRKRKNHKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NF53</accession>
    <name>A0A167NF53_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_75845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293798.1">
        <property type="nucleotide sequence ID" value="XM_018443100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NF53"/>
    <dbReference type="GeneID" id="29004006"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_75845"/>
    <dbReference type="InParanoid" id="A0A167NF53"/>
    <dbReference type="OrthoDB" id="2153609at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="4"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="196" mass="22119" checksum="DCF0D3A1E2CBDE77" modified="2016-07-06" version="1">MSAQFNFNRLPHEIISIVMNHLPLKDLVRIERTSKLIQDFCLEEIEHRMSSGSAAQEWGLMIHLGQTIASPSQFDPKTKTIAYSVPMDPVNINTMFDHRRQIHCSLLRRIPSTPNYNLSEPFVITIQKGMAEGHTEQLDIQGKLCQVQASITRLVTPSQEGQDDKNKKLILAPAPLTYALQVTQMRLPLSTLATVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P073</accession>
    <name>A0A167P073_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_165485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295028.1">
        <property type="nucleotide sequence ID" value="XM_018435247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P073"/>
    <dbReference type="GeneID" id="28996153"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165485"/>
    <dbReference type="InParanoid" id="A0A167P073"/>
    <dbReference type="OrthoDB" id="2210431at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="525" mass="60780" checksum="6C7525618EA17B9D" modified="2016-07-06" version="1">MATYTYFINKPFFMEVFLSLVERQVRDGIKSGNGKSKMKDETLRYRDFIMKHKEACCEHAGYVPPKLTHAKQSADYESTRIPTAYINNIKAHFARKQLPRGDFLDENQRSLVASILAIYPESYTLLKSSIYYDVQAIPLNHMKAFCKLGQLLKPLPFDKKALKKQKVDKSLFFQEMMLTNGVSVTILKQNFESGRCQKTDAAVTSGESSTNTGRKIKRTKTINEDSFTNNYDKQFSIISIYKKSKKQEITTVKVFNKQFEARVYPIEKTGDIYYGKHLMFIKRLRDARPGIAKLDAYIYYLTLLLSTKHIARRLASQKEQLSEGVNAKQVQVKQGPHVIVPKLLVLPFRQMKFISNINYDRCDSRLAEDLRIFFEKDPVFVFGDWSAPNVKFQEPSRNKDILKYLEKSRFSIYMINEYKTSSCCSICPTGEMENFKKNANPRPLQREKFPNVLCHGLLRCKNKACLVNGKGRLFNRDTAAAINFRLILNSLREEDRRPPRFIRTSKVLFSGLGIIQNYVIKKSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P312</accession>
    <name>A0A167P312_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_108983</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295194.1">
        <property type="nucleotide sequence ID" value="XM_018428084.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A167P312">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167P312"/>
    <dbReference type="GeneID" id="28988990"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_108983"/>
    <dbReference type="InParanoid" id="A0A167P312"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="592"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="706"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1142"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1181"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1222"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1251"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1378"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="92"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="776"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD77154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1404" mass="158443" checksum="CCDBF60DA3A2EC90" modified="2016-07-06" version="1">MYIDAICEYKDLKSKLASLSRKSTNPSKLEEGNLSSEDFNLDEFLHCISNESARIGHTKKHIGVIWRDITVKGIAAEAHTISTVASLPIAIFKMMKLLIKKQDVPQKVILHNNTGFCKDGQMLLVLGRPGAGCTTLLKIISNMRGSYTSIDGDVSYGGIDPATFATHYHGQVCYNEEEDQHYPTLTAKQTLQFALRTKTPGSRLPDETRRDFVNRVLYMLGNMLGLTKQMDTMVGNAFVRGLSGGERKRLSIAEQMTTSSSINCWDCSTRGLDAASALDFVRSLRIMTDVLHKTTVATLYQASNSIFNLFDNIILLDEGYCLYFGPVEQAKPYFEQMGFFCPARKSTPDFLTGICNPLEREIQPGYENRVPQFAHEFQKIYMDSHIYKSMMVDLDEYESKFRADNQADVFKQAMDEEHQKRAPTTSPFIASFYQQVRALLIRQYHLVIKDKSALFSRYATIILQSLVTSSCFYNLPLNGTGAFTRCGAIFFAVMFNAFVCQSELVQFLMGRPVLKKHKQYALYRPSAFYIAQVIIDIPYALVQVFLYTVCSYFMSGFNLTAGKFFTFCIILFFINMTMNGFFRIFGAITSNFFLATQLSSLTLVGFIAYLGFTIPYSKMHPWLYWIYWANPLTYGYKALLVNEMNGQKYSCDGPGNAVPFGLGYTDWDYKICTMLGGVPGENFVKGESYLLKALDYKPWEAWAPDFIAVVGFFILFTVACALSMEYLDSDNGGNTTKFYLPGKAPKHRNDQEENERRKRLAKITEEMDSISTGTTFSWQNVNYTVPVKGGNLQLLTGINGIVKPGHLTALMGSSGAGKTTLLDVLARRKTAGVVEGEVFLNGEALMNDFERITGYCEQMDVHQPAVTVREALRFSAYLRQDESVPKAEKDAYVEKIIQLLEMEDISDAQIGMVEEGVGISIEERKRLTIGMELVGKPQLLFLDEPTSGLDAQSCFNIIRFIRKLADAGWPVLCTIHQPSAILFSHFDHLLLLVRGGKTAYYGEIGPDARTMIDYFQSNGGPVCPPEANPAEYILEVVGAGTAGKASRDWSEVWAGSEKSKELDAELADINRTANKKPARKAHTYATSFWTQFKLVVNRSFLTYWRSPDYNVGRFLNLSMSSLTCGFTYWKLGTSSSDIQNKLFALFSTFIMAMTLVILAQPKFMNERLFFRREHASRYYSWIPWGISTVLVEIPYVLVYSAAIVFCFYWTTGMSNSTESGGYFYVMITLLIIWAVTLGFIIAAVSELPTVAAVLNPLVVAMLILFCGLLQPPSYMPTFWRKWMYWLDPFHYYIEGLTVNELEYLTVVCAEEDLLRFSPPPGRTCGQYMANYFSFGGPGYISNPDAAQPEQCGYCNYKSGVEYYTLIYGWSASNKWRNVGIIACYVAFNVIVFLGLVYWNRRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PCR7</accession>
    <name>A0A167PCR7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_60812</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295724.1">
        <property type="nucleotide sequence ID" value="XM_018440701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PCR7"/>
    <dbReference type="STRING" id="763407.A0A167PCR7"/>
    <dbReference type="GeneID" id="29001607"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_60812"/>
    <dbReference type="InParanoid" id="A0A167PCR7"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005221">
        <property type="term" value="F:intracellularly cyclic nucleotide-activated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000057">
        <property type="entry name" value="Cyclic nucleotide-binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF11">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="9">
        <location>
            <begin position="36"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="9">
        <location>
            <begin position="199"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD77684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="678" mass="76082" checksum="B05754A84A847413" modified="2016-07-06" version="1">MMLDVEKDTKWNTQDYTTNLSIPPKLLSSLREHSLFQRTGDEAFLHQLACSMHLRNYSPQDVIIREGEPAKAMFFLLRGSVSVCSADYERVYAILKQGSCFGEIGILYSMPRTATVIANDKCTVAVLMAEDVSTLLPRFPQVEQMLRYEAEERLALLKKSQQQFNSSGGRIKTRKPSFERNVEFFVRTSTYERLRKISFFKDSPEEFLHQISLCVQPRQYMPNVLIIRKGDIGTELFFIIEGTVEVVIPSTTDVVVARLSAGDSFGETTVLLGTPRAANVRTITNLEVYVLNRKDFLDVCQNYPELQQHYKRLAESVLQEYNKRVKVSEESHVMPDKLQALGASLLGYVATFLDFSGLVRLAAVSKKYRCFLQNNKNLLHQVDLSPYNNHMTDAVLMRAVVFAGDRTQDLNLSHCFHLTDEAIKVISETMPNLKSLNINSCWNVTDKGLLHLSSNCPRLTSLDLSNCRKITNKGLTALIQSKAAEGFDGLTYLSLSYCKHLSSLTMSALATYCSGSLEYLNLQRCTGVSTKDFEALSNVNFSALHTVILSDCSFLQDPAIIALVKAAPNLERLSLSFCCSLSDASLEAVTMLKHLVELDASYCCSAVSDTSIYMLLQAHKYAPLSLNIRGCFRVTDQGLKPTLDKEVQLDYLNISQCPNILSQTKRVLADIYVDKISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PDH2</accession>
    <name>A0A167PDH2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_60838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295756.1">
        <property type="nucleotide sequence ID" value="XM_018440705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PDH2"/>
    <dbReference type="GeneID" id="29001611"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_60838"/>
    <dbReference type="InParanoid" id="A0A167PDH2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="202" mass="23372" checksum="0EAC94BA19D3F436" modified="2016-07-06" version="1">MKSPLKAQKLPVFTEDENMFASFILNTMVVKNHTKCCPLVGCLKKKSNIDSFSIRLKERRKSESVTVVRSDDKLKRRKLTTDIDVFTSGQGSQKNQFKLNTDRQASHTANALDREPVAIHISQDFMANLHTIYGIFHVNDVHKTQIKVLWSFVLKKVNEPLLLRSKEGHHRFCFGFYLLYDVFESFVFSKGRDGENLRKHIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PH49</accession>
    <name>A0A167PH49_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_141770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295946.1">
        <property type="nucleotide sequence ID" value="XM_018430664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PH49"/>
    <dbReference type="STRING" id="763407.A0A167PH49"/>
    <dbReference type="GeneID" id="28991570"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141770"/>
    <dbReference type="InParanoid" id="A0A167PH49"/>
    <dbReference type="OrthoDB" id="76265at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051559">
        <property type="entry name" value="HIF_prolyl_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12907">
        <property type="entry name" value="EGL NINE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12907:SF26">
        <property type="entry name" value="HIF PROLYL HYDROXYLASE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="8">
        <location>
            <begin position="202"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD77906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="309" mass="35577" checksum="220F59BEDB475115" modified="2016-07-06" version="1">MDTNTNDSLESRILRAAAANHADLPEFPDDKSDLPSDYEYDPNADEEEEVEEVEEIDENDLLEYLDQQEHPLTIAQRLFYHELNTVESQKHSSSWDLKCLQPKNLEELYSQGWTIADGLIDLETLKGARKEAEDMLAKGAFCHPCNPDNDESFDPYRDENARDDTIVWLNPAKRDETDISRILEFFEGPLHHDIAEMIRLNGKTEYQLAHYHPKEAHYERHRDAFPVDDPNDTHQRRVTAIVYLNPGWSHGDGGELKLFGQLEKHGLRESADRIVQPLLGRVVLFMSGVVDHAVMNATKDRFALTAWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PL47</accession>
    <name>A0A167PL47_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Receptor L-domain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_121769</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296196.1">
        <property type="nucleotide sequence ID" value="XM_018428828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PL47"/>
    <dbReference type="STRING" id="763407.A0A167PL47"/>
    <dbReference type="GeneID" id="28989734"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_121769"/>
    <dbReference type="InParanoid" id="A0A167PL47"/>
    <dbReference type="OrthoDB" id="536881at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051648">
        <property type="entry name" value="CWI-Assembly_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000494">
        <property type="entry name" value="Rcpt_L-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018:SF3">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01030">
        <property type="entry name" value="Recep_L_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007891195" description="Receptor L-domain domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor L-domain" evidence="7">
        <location>
            <begin position="43"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD78156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="328" mass="35032" checksum="5A34CC18EC602A29" modified="2016-07-06" version="1" fragment="single">MTRLSLTAIVLAISAVTLAQAQGPECSGSIKPISQGDLEAIKNCKVFTGSILIDATQEAFLTLNGVEEITGDLIVQSSVDLKSFSAPQLKVVRGELKLQNHTILERADLPALVEAKGLTLAILPGLQIIQFPSGLNKVESVRIEDTRAPAVTGLGPETMDTFILTNNNYMRQFDLSTVKQMTGTLFITSNGQGLDFGATNLATLRSATFRNLAQLNLPVLTTVAADISFHQNEFTKLSLDGLEMIGGTMTLANNDRLTETSFKSLFKIGGALSIGNNTQLKAIDGFSKLSEVDGTIDLAGAFDLYAMPAIQDIRGGMRLQTSSSVFPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PN32</accession>
    <name>A0A167PN32_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_163355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296278.1">
        <property type="nucleotide sequence ID" value="XM_018434778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PN32"/>
    <dbReference type="GeneID" id="28995684"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_163355"/>
    <dbReference type="InParanoid" id="A0A167PN32"/>
    <dbReference type="OrthoDB" id="10383765at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="631" mass="72911" checksum="5A69C2E526EFA1D2" modified="2016-07-06" version="1">MGFSELPTEILIAIANKLTPKEWRLSGTIFRKWNELMRETQWKRIQITPLNKHKFFSPVGGQDDIYKTCGDYVLDLTLSSSLSIDDKSLRLLQRHFQGLDFLKIFDASLTGSLVNSTTDWSCWSSLTRLKVFTKGEDSIDIPEIFIKVLSKLPNLQHLDYTKDYTSERPLYTLRDLEELHSCLPQLQELFLTVDLDILNQRDLEYMLKAAPMDHLTVVKFRINTTDLRWLYYFARKYPKVYLMEWRNTSIAETSNDIQDQTLSMLKALPHAFSNLNTIVTSSTTKSEWTSFLFKNCLDQFYVPLQNIRYFMFDDNLDPTQSEKSFDDCLRYFPKSLERLSISSNDSITRQCMIPNILGNIPNLVVLAIDMTNSSIELDILLNHCRFLRVLRLKVHGIYLSNDAFESMGRHDLALVEVGDAFIEKDLFLYISQRCKRLKYMRLVETKVYGPISSRREAFCLDMSHTEFSHLQFNGVSFYESKNDVVLTQIPLRMVTLVQTKEFLQAKGTKGPGVSMVVGNTGRSISSISPWFLTYSNRINGGEGKQGPISQVSMEYIFEYYRCLPTRDVEFRLQDVSVSPSYIGELRQKVGYGPTDIRSYVKFMCAHVSKYVIKTASFADNDFWAKLCEGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PQ60</accession>
    <name>A0A167PQ60_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fork head transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_95336</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296379.1">
        <property type="nucleotide sequence ID" value="XM_018443896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PQ60"/>
    <dbReference type="STRING" id="763407.A0A167PQ60"/>
    <dbReference type="GeneID" id="29004801"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_95336"/>
    <dbReference type="InParanoid" id="A0A167PQ60"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000135">
        <property type="entry name" value="forkhead box protein G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="4">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="3">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD78339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="95" mass="11028" checksum="952EAAF7A2EE8D33" modified="2016-07-06" version="1" fragment="single">KPSYSYASLISQAIGSTPYRRMTLHGIYTFISTNYPYYQMNSNGWQNSIRHNLSLNKAFIKVPRCDAEPGKGAYWTIDTNAEKQFSNGIYHRNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PXS4</accession>
    <name>A0A167PXS4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_179674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296776.1">
        <property type="nucleotide sequence ID" value="XM_018438190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PXS4"/>
    <dbReference type="GeneID" id="28999096"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179674"/>
    <dbReference type="InParanoid" id="A0A167PXS4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="141" mass="15652" checksum="C661CD5D712D9EA9" modified="2016-07-06" version="1">MPNESAQPTRRRAWWWKKSNKPAEEISDTELEGEQPMLILLASQDAASSLQAHRPRSERSSAMSVVESTASIWSKPWVSQTHEEGQLDRPLVASVSEPTLPQQRSSGSSVWPGKLKAGFGRLVGRSQSDDKETKDPSQDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q6I3</accession>
    <name>A0A167Q6I3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_58204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297197.1">
        <property type="nucleotide sequence ID" value="XM_018440278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q6I3"/>
    <dbReference type="STRING" id="763407.A0A167Q6I3"/>
    <dbReference type="GeneID" id="29001184"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_58204"/>
    <dbReference type="InParanoid" id="A0A167Q6I3"/>
    <dbReference type="OrthoDB" id="6077599at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140293">
        <property type="term" value="F:ADP-ribosylglutamate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140291">
        <property type="term" value="P:peptidyl-glutamate ADP-deribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042278">
        <property type="term" value="P:purine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02908">
        <property type="entry name" value="Macro_OAADPr_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF27">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="24"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="213" mass="22979" checksum="4CC6E88E33049659" modified="2016-07-06" version="1">MSSIAERGAANLKTMYARMGKSIEANEKLVSSMASKVSLCHTDITKLKVDAIVNAANETLLGGGGVDGAIHRAAGPRLVEECSTLGGCREGEAKITAGYNLPSKHVIHTVGPQSEKPDVLANCYLNSLKLLEQNNLRSIAFPCIATGVYGYDNEKAANVALWTTRKFIQDRMTAGKDPVDKIIFDLFNQKDIAIYKDLLPVYFPAASTTIENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q7M7</accession>
    <name>A0A167Q7M7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_179028</name>
        <name evidence="2" type="ORF">PHYBLDRAFT_181282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291637.1">
        <property type="nucleotide sequence ID" value="XM_018438444.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297266.1">
        <property type="nucleotide sequence ID" value="XM_018438085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q7M7"/>
    <dbReference type="GeneID" id="28998991"/>
    <dbReference type="GeneID" id="28999350"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179028"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_181282"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD79226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="139" mass="15251" checksum="1C4A9775334DDC81" modified="2016-07-06" version="1" fragment="single">MSKRIKSMTPSSLSPHYAAQSPSGRKPDLVAKEVLEWWQTNGKHPFIQPHISSPSNVGANSPENLPLGDKVQLIRLPVASPSAVKEFSQVSSEEPAHLTTETMPHDFSELTELASNNFHFPMLVAWKNLPATVARDASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QFY3</accession>
    <name>A0A167QFY3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">High-temperature-induced dauer-formation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_35188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297679.1">
        <property type="nucleotide sequence ID" value="XM_018440048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QFY3"/>
    <dbReference type="FunCoup" id="A0A167QFY3">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QFY3"/>
    <dbReference type="GeneID" id="29000954"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_35188"/>
    <dbReference type="InParanoid" id="A0A167QFY3"/>
    <dbReference type="OrthoDB" id="432953at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="614"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="679"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="828"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="628"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="655"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="687"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="828"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="847"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD79639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="858" mass="97951" checksum="06264412D42B4DFD" modified="2016-07-06" version="1">MGATDSKLAFRKGVFRLFEERHIPPSDDYWSLFWTIPETADDVFSLIGASDVRRARDNARENLETLIDKTIDRMEAITNAPNFPSAQYSINHLLNCCRIMTRIMPYIYESPECSEWEDSFFWTPRLVEKKAPENSEDETIKGTFDEQQQQHQHQQQQEPVIDTKPQPQYDTLPPRGEVFLSLVIRCLFLAGFTLPISMTTKDSRVVYAIWEAGVGSSKEIGTYKDNEMNRTEVLRLLTVLLSKSMYISSSQLLSKEDLWLRFVAAKTERKIVLVVLCSLMNTACKYDPIGWGVPYNHVLIANPREKLVTMCLRVLLILLDYRSPRISHWMRHIDQQQTKNSLNGRNVFRHYLSKLHRSQDFEFLMDGMYRILLNPLQASNTYLPGSTKRVECNIEVMMLCWRVMEINLKFRTYLMETERALDLMVVLIYYTMENRSNVAQVGLVRMCTFILQTLSSDRTFGVKLNKQFVSQSYLPALIRIPASHGTYGDFLIISIFSLIATTRGTLSTLYPALVLTISNVSPYLKNLSVTSSSKLVGLFSSISAPGFLLADESNYRLLSYLIEAFNNIIQYQFTDNPNFVYAIVRNHAKFERLRDLSFTNALAEIERLRQLKESKIQTDQGPEENKSVVETNNGPDVNKSQESLAENPSSPRNTGSNSEGNSEESQAIQNTKLFAQGLSESPEGQDFSRTPQRQGSISSTISTPSVLPGAKHGFVPTEEWWSRWHSQLPLQPILLLLEHLVPQVEAKCAAESLTTDAQVLEFLRQITLVGILPHPQPIFIRKFQWGEALFIWFRSMLWGQAYVSSLSEYGAWNGTQVKLFQIKQQVAPTHQQRQSSENPTPSPRISLASNSQQPSTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QRB8</accession>
    <name>A0A167QRB8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_140143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298170.1">
        <property type="nucleotide sequence ID" value="XM_018430336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QRB8"/>
    <dbReference type="GeneID" id="28991242"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_140143"/>
    <dbReference type="InParanoid" id="A0A167QRB8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="133" mass="15754" checksum="BA42960CB7717423" modified="2016-07-06" version="1">MSRTESLFTDTVDHQYSKPYPHRLVFVSYRYLHTRLNGRNRLNRCKRFDRRSGRNNNRRTSCSSRNSRSSHNRLVVVVVVVVIVVIVSYRRNNRNRRKVRNVRNVRSGRNGRSRRSRCIILIVVAAVAVVIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QUD2</accession>
    <name>A0A167QUD2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_160935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298328.1">
        <property type="nucleotide sequence ID" value="XM_018434316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QUD2"/>
    <dbReference type="GeneID" id="28995222"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160935"/>
    <dbReference type="InParanoid" id="A0A167QUD2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="339" mass="37887" checksum="ACD28A56442B7443" modified="2016-07-06" version="1">MAPRTNINQNARTNGSTSRPLINAVNTGRIESSNPMIAPRPENMSIPVSEFNDVVSLLATLNDKMTAVSSDVSELKVQCQVGAQSTGMQAVLDSDMDPQDIISSSRHPKISSIIWGRLRDINLKIDDLELIRENDDKPTWDINVGLSDEFNKNLASDLMLYIRRQPVAAMVPPKELCGIIVNSYYNRLATICGISECIYCLTSVGVTIMTSSHKSALGLPTKLAPYRSDTVYPALNKRRKRTYTKHKDAVTEKFNWDYNGVFYRDATSGDETETNTSVVASRPDWRSDELNTVFNFLDELARDDLGKRATQLKSRSHVLVHETIPCGLVTKMPTWSKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QWH6</accession>
    <name>A0A167QWH6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_104926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298427.1">
        <property type="nucleotide sequence ID" value="XM_018427870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QWH6"/>
    <dbReference type="FunCoup" id="A0A167QWH6">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QWH6"/>
    <dbReference type="GeneID" id="28988776"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_104926"/>
    <dbReference type="InParanoid" id="A0A167QWH6"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF3">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="42715" checksum="DE1294F9E742E8C0" modified="2016-07-06" version="1" fragment="single">PPLTVENITRLREKATASSNPLELLEFAMFLVEAAPHVYADEGDQRITQKRRNSLLHEAQKIVKRLAANANIAKSGCSEAQFFLANCYGTGVMKTPIDPEKAFNFYLQGSKQNHLQCCYRVAVCYEIGTGTKRDNNRAIQFYRKAAKLGDPLSMYKLGMILLNGFLGVHKNEREGVSWIRRAAQSADQDHPQALHELGVIYEQTNIVYILPDIDYSRELFTQAAQYGFAPSQRRLGLAYENGSLNCPINPRRSIAWYSRAAEQGDVESELALSGWYLTGAEGILQQDSFQAYLWARRAADKGFSKAEYAVGYYTETGVGVQESLKEAKRWYLRSASSGNQLAKIRLDNICTPDNETSKQKMKICNSNGKFNAKSRECIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QYU2</accession>
    <name>A0A167QYU2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA endonuclease activator Ctp1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_161133</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298527.1">
        <property type="nucleotide sequence ID" value="XM_018434350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QYU2"/>
    <dbReference type="GeneID" id="28995256"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161133"/>
    <dbReference type="InParanoid" id="A0A167QYU2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013882">
        <property type="entry name" value="Ctp1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08573">
        <property type="entry name" value="SAE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA endonuclease activator Ctp1 C-terminal" evidence="6">
        <location>
            <begin position="110"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD80487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="182" mass="21392" checksum="895B9C1403619D86" modified="2016-07-06" version="1">MIDHKELISRLAKERSSRKQLEDIIQYQKRQLEEKEQTIAQLRLMRWSISSSIEDHRKSSNHLNNQDRSSNSPALDSPLLVEKSLETLHIYDHELEPVSSPISSTVHLHEDAATSNYMQNSENENERRIEKENAMSFFKKNESSSVESQSDESLLEKSFSRRKKTKRSLTPPRFWDQTFPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R9F0</accession>
    <name>A0A167R9F0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type zinc finger transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_72980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299199.1">
        <property type="nucleotide sequence ID" value="XM_018442755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R9F0"/>
    <dbReference type="GeneID" id="29003661"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_72980"/>
    <dbReference type="InParanoid" id="A0A167R9F0"/>
    <dbReference type="OrthoDB" id="2404451at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD81159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="802" mass="92586" checksum="288E2755B6CD23CB" modified="2016-07-06" version="1">MSSTSELYNKKCYCTKCSDNQQGYSFVSTQTFQCHNKRARYEDMERNVSVQRNLVDIDFETTSNQQTRPIEAIGSRTNSSVWEGAPISDNEIAFSNVVFQFLKAFFLYYIWLLECIYCLTSVGVTIMTSSHKSIWITTSNELNDESSDGDENDNDEESNGSEESEDDEENIVEIEVEEFDTEDPFATTNMPENPVHRFIATFVVMFVSHYVVNKGTVVLIEFIKKLLSIYKQDFQLPVSLSGLQSMTELSVMTKEIKRFVVCQDCYKVYEESVAAPLNCDFIKLGAHTTCNCKLMSYVYQSLKRALKILFLCLDFEQKIMHWNQEFKITAILCDVCDGEAWTDLKGNDNEIFVENFCSLMLTLNINCFQPFNGTSYSCGAIYLVINNLPRNGATVRAALLMVACDIPAVRKTSRFTAHTSTCACYKCNNQFSRLPGTSLVHLRGFDCQQWRHRSDRANRVHAEEWNSASTPSERQQLEVEYGVRWLQLYCLGYFDLVRGMIIDSMHNLFLGTPKRMIETWTKIKKMKNNDLLAMQTVAATMIFPSNYTKLKTKTGKDFSHMKADEWKSWVLVYSPMLLKLVLPSNMFNGWMHYVKACHILVKPSISFIEVDQAHSYLQEFCQSCEDIYEPKVLTCKMHRHLYLHDTIRDFGFVYGYWLFGFERYNDSFLSRAAPIKGNEPLPPSSFPLQSLKESTMSDIDYPQLLDYYKIAYVIPNLISYHDARLSQYFVNNRITKLKSIDLLGQTYIGNNSSGKHGSLVQAFFHMVCSSINIKVLKSFQFYLKKTPIVEYIEAPYFILWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N7P1</accession>
    <name>A0A162N7P1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_98127</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the RFT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD71888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289928.1">
        <property type="nucleotide sequence ID" value="XM_018444042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N7P1"/>
    <dbReference type="FunCoup" id="A0A162N7P1">
        <property type="interactions" value="391"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162N7P1"/>
    <dbReference type="GeneID" id="29004947"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_98127"/>
    <dbReference type="InParanoid" id="A0A162N7P1"/>
    <dbReference type="OrthoDB" id="9979195at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034203">
        <property type="term" value="P:glycolipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007594">
        <property type="entry name" value="RFT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MULTISPAN TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117:SF5">
        <property type="entry name" value="PROTEIN RFT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04506">
        <property type="entry name" value="Rft-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD71888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="436" mass="48359" checksum="F2EB46EBD8970721" modified="2016-07-06" version="1" fragment="single">DGVLASSVKGVYYLIMLQLMSRLVTFVLHQVVLRFTSAETLGIASVQFELLLSTILFLSREGFRCALLRRILDTTPEGVEQKTTNVSYIPTCLGLITTILACSYFLSFDQTCPHYHLSVIIFGVAAMAELVIEPLFILALQRLYFQVRVSVEGVAVVLRCLVTFGLTILGSRGNGENTYGVLAFAIAQLVFGLTMMVGYLGFFAMEVSKGNIALRSLYPLYWFDRTLLDLSITLTKQSLLKHILTEGDKMLITALSTDDNQGIYAFVVNYGSLVVRILFQPLEETGRTLFSKVLSVSPDQKENSITTVTDVLLVIIRFHVLLGLLFVCFATNYTSTLIDLLVGKEWSTVRNAPQVLSAYCLYVPMMGINGITEAFVQSAASSSDLTRQSYAMIGFSICFMLAGYLWMSVWDFGAIGLVMANMVNVSIRIVYSLHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NDP0</accession>
    <name>A0A162NDP0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_168716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291398.1">
        <property type="nucleotide sequence ID" value="XM_018435924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NDP0"/>
    <dbReference type="GeneID" id="28996830"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168716"/>
    <dbReference type="InParanoid" id="A0A162NDP0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="118" mass="13868" checksum="04A6FB2275394290" modified="2016-07-06" version="1">MNPTSQSISAQSSSGEQKSRRRTKQKNERIPMTLRKRIFNLTLPLALTVSLDIKQVWNAKPFHLKYSFIVSRRNSDSVLKLPELERKRKPLQKKQYMVKINLRRQSTGMAYNLRLVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NDZ6</accession>
    <name>A0A162NDZ6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_150264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286714.1">
        <property type="nucleotide sequence ID" value="XM_018432438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NDZ6"/>
    <dbReference type="GeneID" id="28993344"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150264"/>
    <dbReference type="InParanoid" id="A0A162NDZ6"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="98"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD68674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="234" mass="26862" checksum="F6B1BBFA01CD8CCD" modified="2016-07-06" version="1">MKPIQFYDLLLPALGEKAWSPNTYKTRFTLNIKKLPYETTWVTFKEIYTLIPDITKTGNPPTVPIIVDTEKEKAIQDSLKIAQYLEVTYPESPSLFHGDEELHRSFQATFDTRLVLHLICIIVLKVVKACGDEAAQARFREVREAKYGKTVEQFAGDPEDHIKQIHEVLKDTRKILAEKPYLTGSKVGWADITLASQLRTVDALDHELFDSRILDDTNGGKSLREWYERMSVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NE29</accession>
    <name>A0A162NE29_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_150294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286744.1">
        <property type="nucleotide sequence ID" value="XM_018432444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NE29"/>
    <dbReference type="STRING" id="763407.A0A162NE29"/>
    <dbReference type="GeneID" id="28993350"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150294"/>
    <dbReference type="InParanoid" id="A0A162NE29"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="79"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="201" mass="23070" checksum="2099653B267483D9" modified="2016-07-06" version="1">MNPNQTAIAKRRKRNKPQKVLLIHIKNMIVEKCHIEESFESDATVEPKKQGGSHIESLKIINECSKFIQDFLIKCCTLTLDEADFNANLIREQGWSKKGKASIVKTKLKRGLNISILAGISYQSVESVQAKLSPDGMIGPIFVEFVKMIMDLLDYSNSAPHNFIMNNVLIHRFYIVIELFANSQHHLHFSPPYSLLWWLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PU19</accession>
    <name>A0A162PU19_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_142962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294017.1">
        <property type="nucleotide sequence ID" value="XM_018430909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PU19"/>
    <dbReference type="GeneID" id="28991815"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_142962"/>
    <dbReference type="InParanoid" id="A0A162PU19"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="173" mass="19498" checksum="5F1B51619F5DD1F2" modified="2016-07-06" version="1">MNSTDNTVIQLLQGIQAALISLKSGQEALLGHREFPDRTIVTSTSTLTGIIPRPVSKINNITLKHIYKMITDDLRIELTEETKRIVNTCTKVICDQLAALPSVQDLGTNPGWSLLPQEDKNRLCINHSIILRDNGIDFTRCHRNWASIARVSQLWRGRKKREYSGILASTIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PY48</accession>
    <name>A0A162PY48_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GATA-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_77651</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293336.1">
        <property type="nucleotide sequence ID" value="XM_018443284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PY48"/>
    <dbReference type="GeneID" id="29004189"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_77651"/>
    <dbReference type="InParanoid" id="A0A162PY48"/>
    <dbReference type="OrthoDB" id="2258182at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="3">
        <location>
            <begin position="309"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="471"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD75296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="502" mass="56212" checksum="B675A9E087FE5AE0" modified="2016-07-06" version="1">MNIADLLIQSPSNTSPIRDEDFMKIWEDVLEKNGFCMRHKLERNSLTDATIAPLSPSSFVGETPVHIKVIGRHMNGSFRCHIGTGKASRPIRSTELCQQMRLLAVFFKAEGSRSQLILPDFILFPTWLLHLFRYTQHGTSPGRTDVRFLENAALAKEDHIYRLNHVLNSLFRFNLRSFDQDKLRSALELANYLFDTAGLEHENLPRPVFSPSSSQPALYTTLISLLHAPRPSKIKPMCHNCSTKPASRRHLCVACYRYQLKHAAPRPLRLIVANRPGPRVSKTQSDLAFPTGDSHSLPMVFYSPKSASSLSRKHCANCGVQETHQWYRNLCGTGHWCETCKSYYLRHTKVRPAELFVKAAKRKVDVRTLVNWTASEDTIGGCINSNNSIHDNHNIHDNTSYIYSHSHSHSNSNISNNSGLDSRRSSSSIESNMPPSPVHARSRSGSAVSSGCSSPTASLFVSMPLTPPDSARVFSSPCRLPPPHLTQTHHSLVPPFSAWSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q0N1</accession>
    <name>A0A162Q0N1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DnaJ homolog 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_186127</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294136.1">
        <property type="nucleotide sequence ID" value="XM_018439197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q0N1"/>
    <dbReference type="FunCoup" id="A0A162Q0N1">
        <property type="interactions" value="514"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162Q0N1"/>
    <dbReference type="GeneID" id="29000103"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_186127"/>
    <dbReference type="InParanoid" id="A0A162Q0N1"/>
    <dbReference type="OrthoDB" id="10256793at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000005">
        <property type="entry name" value="Chaperone protein dnaJ 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF52">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="77"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="10">
        <location>
            <begin position="233"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="233"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="456"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD76096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="534" mass="57705" checksum="F1E62A3C73D06464" modified="2016-07-06" version="1">MVILRTAWRSFAANKSVTETFCQKAGHCNSIHVSPTNTQWFQSAVKANGSVFGAIPSICGQKRGFHASVPSRSSKKDPYEQLGVGKTASQSDIKKAYYAASIIEIHLNALCISILYNLSLELAKKYHPDTNKDKDAREKFVQIQEAYEILSDEQKRQQYDQFGHGFEGAGGSGGFHGGGGGFPGGFDPNDIFSQFFGGGRGGGGRGGNDPFRNAPGDDIQVPLTLSFMEAVKGTTKFVNVDKVVNCSTCKGSGMKAGKQKSTCQSCHGSGVQTIMMGGFHMQTTCQTCGGVGTSIPHGAGCSPCDGVGKVRDRKTVQVNVPPGVDQNSRIRVSGEGDAPIKGQGSNGDLFVTLNVIPSKIFHRKDYDLFVEAKLPFYKAMLGGQIRIPTVDGDVDLKIPSGSQPGDNVSLRGRGVQRLRSNIRGDQIVTLKVELPRSLKGKQRELIEQYASLVDEDYRPKESVTPTSPDTPPPSPSPSSSSSSFENDNDDDDIKESTKETEKHKGFLKNAFGKLKDKIYHEDKDKKDKDNNTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q9H9</accession>
    <name>A0A162Q9H9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_138748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299246.1">
        <property type="nucleotide sequence ID" value="XM_018430067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q9H9"/>
    <dbReference type="GeneID" id="28990973"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138748"/>
    <dbReference type="InParanoid" id="A0A162Q9H9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD81206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="323" mass="37350" checksum="09FF9A9D358813DB" modified="2016-07-06" version="1">MSRNLNNNSVNNAFGEEPSVGSPPRNTNDIRTIMLQHSQGTVSNQRPLAPKRARLNLEGDSSGRTRNIHDVYEKLDTMNGVLNTVLKNTSSEKAEATASNAVEQDMSPGRQPTLDQLLRDYLSEEKLYDQYNTNENKNSEGNRLVLKSVTDYLCRQEEGKKVDLPTLRTKIVRHIGNRKLQEKKTGEKKQEENRRACLCQRRVKSCERRQSALKANRAHFVNSFGENVDSILHADYMSDLESDDEREEEEQDSSSEKSFFWRFRPSWRSEEGDRFIDELDADYEAAHDKKNNTHPFEHKFKGIRDKQLSKTKENKLPSWSKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162SZL7</accession>
    <name>A0A162SZL7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_176456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441039">
        <property type="protein sequence ID" value="OAD65062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283102.1">
        <property type="nucleotide sequence ID" value="XM_018437781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162SZL7"/>
    <dbReference type="GeneID" id="28998687"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176456"/>
    <dbReference type="InParanoid" id="A0A162SZL7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="359" mass="39898" checksum="88DA10F5FB095AF8" modified="2016-07-06" version="1">MVNNRQSIAPAPSPEYTELLRRLTAMEESLKTMDSNIGIVIKGNKDSLEILDSVADASGELLAVIAPTTIPASASVPFAASSVGSTLDWYTTPSEAFFGISSAAPSVAPSVGPSVAPSVGPVVLTGANAGELSKQDRTRVLALIRGELKKHNFKSNKPELVAANDSKRSWDVNVDYRLPPNRQLMHDLHAYLAPKVVGTSVRQADISDCIYTNFCGTRRRVKESYEARKKTNFRSRKAGRETDHFDRRELTYHTFKAEIDMKVGKSCDGLLQKEAMSEGESEDDMPGVSSNRAIRTVRPSWRSDEYNHFLAVVDDFMRNRMDFNSRQMLKRSFGRDAVLAVPPRLTSLLPHWAFRDEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T1G8</accession>
    <name>A0A162T1G8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_72303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441010">
        <property type="protein sequence ID" value="OAD65492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283532.1">
        <property type="nucleotide sequence ID" value="XM_018442632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T1G8"/>
    <dbReference type="GeneID" id="29003538"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_72303"/>
    <dbReference type="InParanoid" id="A0A162T1G8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="108" mass="12284" checksum="14B153B9886CD996" modified="2016-07-06" version="1">MPSYFQAKDISTTPDFEEIHKITESKKASAIYLKENNIFYEQIGIIVERSFTGSAIPETAATEMTLNTIVYLIWCFILNHLLNMIEEAIKLSAKTIDTFMADIQKAIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T2C5</accession>
    <name>A0A162T2C5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_175875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441008">
        <property type="protein sequence ID" value="OAD65702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283742.1">
        <property type="nucleotide sequence ID" value="XM_018437597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T2C5"/>
    <dbReference type="GeneID" id="28998503"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175875"/>
    <dbReference type="InParanoid" id="A0A162T2C5"/>
    <dbReference type="OrthoDB" id="2506095at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006912">
        <property type="entry name" value="Harbinger_derived_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47150:SF6">
        <property type="entry name" value="OS01G0872900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47150">
        <property type="entry name" value="OS12G0169200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04827">
        <property type="entry name" value="Plant_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="129" mass="14578" checksum="6503922372FE78F7" modified="2016-07-06" version="1">MGYYLTDGIYPTYGAFVKSLNDPRTPKEKNFAKAQEGSLDHPGCGIETHFMTACIILHNMIVEEKRKSMEMGHADDGQRIADERQCIDIDPVSTLAPVASGFGECPFPEGSFARYLQRHLEIRNRDQHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TF01</accession>
    <name>A0A162TF01_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_175148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441002">
        <property type="protein sequence ID" value="OAD66603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284643.1">
        <property type="nucleotide sequence ID" value="XM_018437424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TF01"/>
    <dbReference type="STRING" id="763407.A0A162TF01"/>
    <dbReference type="GeneID" id="28998330"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175148"/>
    <dbReference type="InParanoid" id="A0A162TF01"/>
    <dbReference type="OrthoDB" id="2281765at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="242" mass="26881" checksum="8E7A909B8534B4AC" modified="2016-07-06" version="1">MYTKKHAEIKNCFKYPHVTMNIHTRCKEPGTEASTWATTAAAAHNSVVVPTALSVRKTPRPPYVRRVAASARMFAIPTGPKGYQYVYISRSRHLTHREVCNSLKTLGVDTGRILDINFPAKDVVGILVHNQYAEKFQTTLTTVAIEILDVFDPLNPKNIADPKYKSLSDSELEEVAAELHSDCCLKALKYLRPHVAVSVGHFFCDQGWISKKDIPVHFVSGPGTGIHDFQSPSRCTSVAMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TJA5</accession>
    <name>A0A162TJA5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor Pcc1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_136907</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285623.1">
        <property type="nucleotide sequence ID" value="XM_018429819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TJA5"/>
    <dbReference type="FunCoup" id="A0A162TJA5">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="GeneID" id="28990725"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_136907"/>
    <dbReference type="InParanoid" id="A0A162TJA5"/>
    <dbReference type="OrthoDB" id="10025739at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000005">
        <property type="entry name" value="L antigen family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD67583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9293" checksum="B961A3AADBAA6751" modified="2016-07-06" version="1">MDHSLKLEIPFPNERLAIIAKRVLSVDKELKTDQVKRTVDTAGNTLTVSFECTSTKMLRVAVNSFLEMLTMVTKTMDQFDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TJG1</accession>
    <name>A0A162TJG1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription elongation factor SPT5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Chromatin Elongation factor SPT5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Transcription elongation factor spt5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHYBLDRAFT_127403</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPT5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD69072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287112.1">
        <property type="nucleotide sequence ID" value="XM_018429161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TJG1"/>
    <dbReference type="FunCoup" id="A0A162TJG1">
        <property type="interactions" value="771"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TJG1"/>
    <dbReference type="GeneID" id="28990067"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_127403"/>
    <dbReference type="InParanoid" id="A0A162TJG1"/>
    <dbReference type="OrthoDB" id="28901at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06081">
        <property type="entry name" value="KOW_Spt5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06082">
        <property type="entry name" value="KOW_Spt5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06083">
        <property type="entry name" value="KOW_Spt5_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06084">
        <property type="entry name" value="KOW_Spt5_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06085">
        <property type="entry name" value="KOW_Spt5_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09888">
        <property type="entry name" value="NGN_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000018">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.940:FF:000005">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041973">
        <property type="entry name" value="KOW_Spt5_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041975">
        <property type="entry name" value="KOW_Spt5_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041976">
        <property type="entry name" value="KOW_Spt5_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041977">
        <property type="entry name" value="KOW_Spt5_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041978">
        <property type="entry name" value="KOW_Spt5_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057936">
        <property type="entry name" value="KOWx_Spt5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039385">
        <property type="entry name" value="NGN_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024945">
        <property type="entry name" value="Spt5_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022581">
        <property type="entry name" value="Spt5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12815">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF23042">
        <property type="entry name" value="KOW1_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23284">
        <property type="entry name" value="KOW2_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23291">
        <property type="entry name" value="KOW4_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23290">
        <property type="entry name" value="KOW5_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23037">
        <property type="entry name" value="KOWx_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11942">
        <property type="entry name" value="Spt5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01104">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="NusG-like N-terminal" evidence="12">
        <location>
            <begin position="93"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="13">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="13">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="13">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="13">
        <location>
            <begin position="604"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Spt5 C-terminal" evidence="14">
        <location>
            <begin position="689"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="575"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="674"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="704"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="738"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAD69072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="784" mass="86866" checksum="D354A8A7C63D3101" modified="2016-07-06" version="1" fragment="single">MAIVDDDDDDEEDDEDYGREDGFIEEETEELPSAAAIQRRHIELDRRRQQETDGMNDEEVAAFFKSKYSARKSQGFRASEEVPQQLLLPSVNDPNLWMVKCKPGKERDVVFGLMKRYFDRLNGDDPLDTFSAFARESLKGYIYIEARRQAHVQQALLNIPYVYHSTLMLVPIKDMIDSISIQRKEVELPLGGWVRVKRGRYAGDLAQVLEVSDSQDSARVKLVPRLDLESDEDDPQKKRKRGLVASRPPQKLFNPERLASRSISSLQKKGPYWFLGTDHFRDGYLEKNMKVATLQVEDVSPTLDEIAKFASGGELNGEDGDRALDLSKLSVQAVNSAQASTLFQGGDTVEVIEGDMIHSIGVVDSVEESSVVVMLDVDGMKKRVTLPAKQLRKKFREGDHVKVINGRYKDESGMIVNVMDSVVTILSDATLNEVKVFAKDLREAADITLTRTVIGNYELHDLVQLDFHTVGTIVKVDRDSFKVLTQESEIRTVAPHQITSKRDTNRAVATDANGNSIRSGDSVVEIDGERRACTILHLYRNLVFLHSRENVENYGVWVNNTRSVVSVAAKRLAQGRDLSRQQQPFGNSHGMGRGAPDSRGRGRDNLVAKTVRIAQGPHKGYVGIVKDTTDDMARVELHTNSKVINVDKSKLVLLDAQGGTIGMAVTNDRFATPNDFAAPSSTPRRYGDGGTTPMHFASGARTPAWNSGARTPNPYTMNGSKTPAWDSGSKTPNPHAFGSGSKSSAWDSGSKTPMWGAETPHRNSGMIAKTPGFVDPGSKTPMWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TLG8</accession>
    <name>A0A162TLG8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Imidazole glycerol phosphate synthase hisHF</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">Glutaminase</fullName>
                <ecNumber evidence="12">3.5.1.2</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="12">Cyclase</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHYBLDRAFT_33080</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">In the C-terminal section; belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="12"/>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286083.1">
        <property type="nucleotide sequence ID" value="XM_018440005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TLG8"/>
    <dbReference type="FunCoup" id="A0A162TLG8">
        <property type="interactions" value="176"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TLG8"/>
    <dbReference type="GeneID" id="29000911"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_33080"/>
    <dbReference type="InParanoid" id="A0A162TLG8"/>
    <dbReference type="OrthoDB" id="10254903at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000094">
        <property type="entry name" value="Imidazole glycerol phosphate synthase hisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000039">
        <property type="entry name" value="Imidazole glycerol phosphate synthase hisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050064">
        <property type="entry name" value="IGPS_HisA/HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014640">
        <property type="entry name" value="IGPS_HisHF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235:SF2">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF/H IGP SYNTHASE SUBUNIT HISF/H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036936">
        <property type="entry name" value="IGPS_HisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51274">
        <property type="entry name" value="GATASE_COBBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 12 15" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="16">
        <location>
            <begin position="6"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="360"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="396"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="468"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="494"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="517"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAD68043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="548" mass="59845" checksum="4DEED9DD893C72DA" modified="2016-07-06" version="1">MSGLYMLDYGAGNVRSLVNAVNRLGYDIKFVNQPSDILKAEKLIFPGVGAFGHAMTALKQKGYTEPLKAYIASGRPFMGICVGMQTLFEGSDESDEPGLGVVPGKVTLFDKKTKAVPHMGWNGAQLVKEQTQIDGQSVDYSIKDESVYYFVHSFAVPYNEKLKDWALTTTKYGDEMFVSAIQKGNVLATQFHPEKSGYAGLRVLQSFLKGTGIVDDSKILTKNPFGLTKDRFTKRIIACLDVRANDTGDLVVTKGDQYDVREKEGDNEVRNLGKPVELAKRYFEEGADEITFLNITSFRNCPLGDLPMLEVLKRTSETVFVPLTIGGGIRDVTDPDGTVHPAFEVAGEYFRSGADKVSIGSDAVYAAEKYWKQGKDGSSAIETIAQAYGAQAVVISVDPRRVYVQDPSQTTHHVVKTNQRGPQGEEYCWYQCTVMGGREGRDLDVRQLVVACEALGAGEVLLNCMDRDGTNSGFELDLIRDVKAAVSIPVIASSGAGCVEHFEEVFAKTNVEAALAAGIFHRKEVPIQAVKDHVLSCGVSVRPIDNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TM37</accession>
    <name>A0A162TM37_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHYBLDRAFT_182799</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287652.1">
        <property type="nucleotide sequence ID" value="XM_018438677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TM37"/>
    <dbReference type="FunCoup" id="A0A162TM37">
        <property type="interactions" value="513"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TM37"/>
    <dbReference type="GeneID" id="28999583"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_182799"/>
    <dbReference type="InParanoid" id="A0A162TM37"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000705">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="18">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="277"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="153"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAD69612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="552" mass="61120" checksum="2D795E5925191A69" modified="2016-07-06" version="1">MTASTSSEGLSNQPVRPSSVTLVMQSDSADSQPRSSSRRSSTHDTILGKPRDRTTFKGVMTKMVDGLNDLLSSHTANKTMAIGTPYNTKHVTHVGYDASSGEFTGLPIEWQTLLQQSGITRMEQEKNPQAVIDAIEFYQGTRSQSEDVWHKIPKASSTPKQSNSQNGSLKYSNSAKTTSSNPLKHLSKLKLSQNGKKPSHTKAASIATDKHVYDSRSEQVKEVVQSEDPISEVLHSPDPSTPPAAQRRPSERHNAKDTEVIDRLMEICACVDPSALYSNMVKIGQGASGGVYTAYRVGDPIPVAIKQMNLAKQAKKELIINEIIVMKEARHPNIVNFIDSYLWKGDLWVIMDYMEGGSLTDVVTCNMMMEGQIAAVCREVLQGLHHLHSHGVIHRDIKSDNVLLSLEGNIKLTDFGFCAQLHDNEAKRTTMVGTPYWMAPEVVNRKEYDHKVDIWSLGVMAIEMVEGEPPYLNENPLRALYLIATNGTPQLQSPDTLSEIFRDFLAKCLRVDPELRPSSGQLLQHPFLLKADPLPSLAPLIKASRESIDNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TMF1</accession>
    <name>A0A162TMF1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_68852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286343.1">
        <property type="nucleotide sequence ID" value="XM_018442018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TMF1"/>
    <dbReference type="GeneID" id="29002924"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_68852"/>
    <dbReference type="InParanoid" id="A0A162TMF1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="326" mass="36601" checksum="6E71B43C8D992412" modified="2016-07-06" version="1">MTNTRRERAIALRPVEITNQQLMEILSTVRADMSTVKEQIGNVEQTLTNMNGRIGVLATTSTKTISAIDSLARTPLAAPVRAELTVAAPVVISNHEPTREESNAVYLSLRTPENILANNLKPRWDTNVAFNKSPNREIAKRLLFNLEHMFGSSSMRQSDLRKRLHTNFTSRTRHERMSDDEIVETNALTQRAARADDNECCRVLAYKDNKEAIDLVMLRDCANTLQKAVMSDGESADEMDEDGIKHVIHIVQPGWRSDECIIILSELLTNVFQCNHFIALVDTYAVQAMGSSANQRIRRITTSVSNSAVPDNISPNFPWWALRDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U427</accession>
    <name>A0A162U427_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_145665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291302.1">
        <property type="nucleotide sequence ID" value="XM_018431509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U427"/>
    <dbReference type="GeneID" id="28992415"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145665"/>
    <dbReference type="InParanoid" id="A0A162U427"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="180" mass="19899" checksum="329AFFEED62DF82A" modified="2016-07-06" version="1">MVEKMKTTRQIAQLLGRRTSNRQIGGSNPPSGIFSNFSQKPRNSSLAVVQIAGFRPPVSSKDKPGLQGPFRSPSLFSVVSHSPQYHSILKHCSEALSVIWEAHFQNIVKEVPIVNNQYLLNYKKSVRKGESTCQKSPYTGRYIIKSFKLKGEKLLIAVAAAATAAATEKKLNSKPIVARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U775</accession>
    <name>A0A162U775_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_169203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290983.1">
        <property type="nucleotide sequence ID" value="XM_018436022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U775"/>
    <dbReference type="STRING" id="763407.A0A162U775"/>
    <dbReference type="GeneID" id="28996928"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169203"/>
    <dbReference type="InParanoid" id="A0A162U775"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051604">
        <property type="entry name" value="Ergot_Alk_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162:SF1">
        <property type="entry name" value="PRESTALK A DIFFERENTIATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="335" mass="38189" checksum="4AE9FE8890B80FC4" modified="2016-07-06" version="1">MLLITGADQYVGFSIVSHLARYEHLRPLTRVLCQNKAPCLNFANKGIDVRQVDYSHPNHLSLAMRGVDHIILAVGNEKDRVANAKHLCQIAAQSGVKSIICISHVGAVSGVHESLQHYALIEEEVINSELQWTIIRPDWIQQNFHLWAALVEKHRHLALPMAENTEICPIDISDICNVVEQLVLDPKEKRLVDSLDNDHIDQVYTLTGPAMINGKQLADSLSEATGYDKMVYRHVRPMDLNYYLNELRKDIWFDARLKQERAQLYRDSFDNDSYRSKAFAIPTATQIQTFVDYFDWVTKTASSICVPHAPMITSMPSRSIDDFFKENANSFKPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UB67</accession>
    <name>A0A162UB67_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_158541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292962.1">
        <property type="nucleotide sequence ID" value="XM_018433810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UB67"/>
    <dbReference type="GeneID" id="28994716"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_158541"/>
    <dbReference type="InParanoid" id="A0A162UB67"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="104" mass="10977" checksum="DEB28A1E4E1A33F9" modified="2016-07-06" version="1">MLLSRNVEPGPRCPAFPVFFRAVEAVLSIGAGPVVVDEDNDNVPVPIPIPVPVPAVAVIVDPDPDPNPGPDPEPILDCSGDCCEYCDIKPGLLAIASFEDLIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UGD3</accession>
    <name>A0A162UGD3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_144346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293033.1">
        <property type="nucleotide sequence ID" value="XM_018431196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UGD3"/>
    <dbReference type="GeneID" id="28992102"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144346"/>
    <dbReference type="InParanoid" id="A0A162UGD3"/>
    <dbReference type="OrthoDB" id="2264705at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="170" mass="19117" checksum="9810B6DCF5CA6987" modified="2016-07-06" version="1">MSGTTLSLSPFDITSWDQIKLFDTGKKNDAAYSQAIQAVQDAQDVPPGCPAILPYNPLNEEIYKCKRMETKEILALLMKHTNLLDKKTVSSFGKWLKSSKVDLLDSPDKRVFTCDNKKYIRLSSKANGPMSGRGKRCSSRPQILQLGIPPDHSPKPFKKKLEYLIFKIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UJ98</accession>
    <name>A0A162UJ98_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_165138</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294652.1">
        <property type="nucleotide sequence ID" value="XM_018435166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UJ98"/>
    <dbReference type="STRING" id="763407.A0A162UJ98"/>
    <dbReference type="GeneID" id="28996072"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165138"/>
    <dbReference type="InParanoid" id="A0A162UJ98"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="28"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="32"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD76612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="370" mass="42867" checksum="A5441B2AACC31CF6" modified="2016-07-06" version="1">MALSYTQDSEDQYTEDSDEFEEEEMNYWLQRCSICFDARLELCLELCRDQFCQECFGLYVTEVVKSSWGLGVTQIQCPVCQRTVPKSEWSKYVSPAVLEHYNKFNQPYRSYTRACPCCETENKPLDYTKRNKDVNHLYASYKLLKDSLGSCTQEGHTEHPSHEDIRHATWMIENPSWSQNNTLPEIYEHLLNAIKKFDLHHPHLPSVGTTIAEHLCQTNMSSDTWRTIQFTHIRNFPDITCSKCNTDFCLQCGEDKHASQSCEDNMRNKLEDSQLSVDLAKTIEWKLENSRRCPNCSIMIHRDEGCNKVDCSLCGFSFCWMCQLPWSPDCGFYRCSSSPDSQIMEKAGIAHTKAELGVPNVHALRQRSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162USE2</accession>
    <name>A0A162USE2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_141615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295792.1">
        <property type="nucleotide sequence ID" value="XM_018430629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162USE2"/>
    <dbReference type="GeneID" id="28991535"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141615"/>
    <dbReference type="InParanoid" id="A0A162USE2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="76" mass="8191" checksum="38FD715BFED7D238" modified="2016-07-06" version="1">MADMSLDAPNASQSSKHCQRTFKYGSTVPSSHVVLKASRQTLGQDFFLDQTSSSSPITSTGLNEQLSRILKSSANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162USX0</accession>
    <name>A0A162USX0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHYBLDRAFT_10188</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295882.1">
        <property type="nucleotide sequence ID" value="XM_018427648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162USX0"/>
    <dbReference type="STRING" id="763407.A0A162USX0"/>
    <dbReference type="GeneID" id="28988554"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_10188"/>
    <dbReference type="InParanoid" id="A0A162USX0"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0187">Copper transport</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="310"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="578"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="619"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="956"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="987"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="18">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="18">
        <location>
            <begin position="98"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="18">
        <location>
            <begin position="181"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAD77842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1019" mass="110313" checksum="FD26205D91CDC702" modified="2016-07-06" version="1" fragment="single">ISGMTCSHCTNAIHKALSELPSVLPDSIQVSLDTATAKLSFKIPSPPEITPDYLRDTIEDMGYDVEGIDWNDDNTSQQDNTTQEIERQSQQEQLPSYKTATFSVIGMTCSHCVQTVNKALAGLPGVIVDSIKVSLDQKNAVLSFQGDYIQPSLFTSTIVDLGYDVPKEEDEEGNNNSGNLTVTKLTVTGMTCSSCVANIERTVMKQPGVTSCQVNLLSKTAVIRHDPSIVGARSLANMIEQIGYKAELSHSQSSDALSDQRKTMRETMDKEIKILLSRFLWSLLFAVPVVLISMIFMMAVPGTQRVHQVFVLPIVPGLSVGDLILFVLATPVQFWLGLPFYVKAYRSLRYAHTANMETLVAMGTTVAYVTSVASVASAIAMKQQGSMSRNYFETSVLLITFIHFGKWLEALAKGKTAETITKLMDLQPEKAILVEVKKPEKENDSDSSGLGSMSLKEGQKDVEHKEHAEEMLQEREIDSKDIQVGDILKVNAGARIPCDGKVWKGDSSADESMITGESVPVLKKESDSVITATINLTSPIYIRAIRVGNDTTLSRIIQMVQDAQASPKAPIEHLADNISSVFVPIVIVLALITYIIWQVLSSLNMYPDEWVPMGESKTIFSVMLGVSVLVIACPCGLGLASPTAVMVGTGVAARYGVLVKGGGYALEMANRITTVAFDKTGTLTLGKPSVTDSWINNATASKQTELVLWKILGRVASGSNHPLSKSIEQRARDIIASQPRQSIFSGDTLLEDDIELPNDSTSNDSSNENDNSVISDFQGIALTNAKEIPGRGLIATLTLSAEAARHLPAVIRHQRALNTAIADIARPESKAVIAALQTKGIEVWMVTGDNVRTGQVIGEQLGIPKEFVLAGVKPEQKADKIRNLQRRGTRAVVAMIGDGINDSPALAQADVGISVGSATDIAIEAASIVLIRNNLMDLLIMYDVSRTVVRRIRLNFLWAFLYNVFAIPIAAGILYPGTGEGLPPYIAGLAMVASSVSVVCSSLLLRLYRPPKDSQSQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UTM0</accession>
    <name>A0A162UTM0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_108656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295923.1">
        <property type="nucleotide sequence ID" value="XM_018428057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UTM0"/>
    <dbReference type="STRING" id="763407.A0A162UTM0"/>
    <dbReference type="GeneID" id="28988963"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_108656"/>
    <dbReference type="InParanoid" id="A0A162UTM0"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22785">
        <property type="entry name" value="Tc-R-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="84"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD77883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="168" mass="18754" checksum="5CEAF6A0BC5AADAD" modified="2016-07-06" version="1">MISVLHSPITQQKFVILDCPTEQTLASYVPRLQEENVRALVRICHRPGTQNPYDGAALEKETGIKVIDDIKFSDGGIPDPAMVERWLKLIDEAKEQGTTVGVHCVAGIGRAPVLVTIALVESGMDGLDAISHVRTHRRGALNKQQVRFIDTYRSKRQKTRSWLGWLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UVC1</accession>
    <name>A0A162UVC1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Homeobox containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_163387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296312.1">
        <property type="nucleotide sequence ID" value="XM_018434787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UVC1"/>
    <dbReference type="GeneID" id="28995693"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_163387"/>
    <dbReference type="InParanoid" id="A0A162UVC1"/>
    <dbReference type="OrthoDB" id="10579215at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007840238" evidence="1">
        <location>
            <begin position="18"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="165" mass="16439" checksum="BF11F07B059E20BC" modified="2016-07-06" version="1">MKFTLIIFAALATIAATADPSSVAEDASAVADPSSVSSSALSSIIPSHASSVGPSAVASSAIVVTPSKPTGVSSSGNPLNGATATASISVVGHDANKDSGATKLALSALAGLLVPAVSIWCCTCPPSRWMNSGHSVVMDIIRIPCTSRNNIDVVTEHLVLVLSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UYG7</accession>
    <name>A0A162UYG7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_140860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296843.1">
        <property type="nucleotide sequence ID" value="XM_018430469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UYG7"/>
    <dbReference type="STRING" id="763407.A0A162UYG7"/>
    <dbReference type="GeneID" id="28991375"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_140860"/>
    <dbReference type="InParanoid" id="A0A162UYG7"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007840281" description="PHD-type domain-containing protein" evidence="5">
        <location>
            <begin position="29"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="330"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD78803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="406" mass="46772" checksum="917F546F78805A95" modified="2016-07-06" version="1">MDVPVFCVPRILLLRILLQLFVIPPHLTEERIGQKQVNFYGVLMDVLQECGHLPDINKFLYTCLHRTFLQAEEPIVNWGWHAARVKDESDWNDIDWKKQNDQEPAALHFEIMTSSARSLIDLELASPAFKVENDPRFSIQDSQGKQIPLDSVLVGTLQYLQKNVSPEERQGTEHLVELRLEQFSRDRYELQRFPATHFVLIGALMKQTTTIMGTSDKWCVYMRDFIEDNAGTNWRVLEETSLESDNQKISTVQAWADIRGASIITDNGRTVEPSVFGQTYRPVYLFYCNQKVLLSNASGPPLKQDGVITMADYSFEEEQYPEPLESDKEQDLCKTCFIAEHAPGNDIYFCDGCDGCVHQLCEDPPIEDFENKIDPWYCRACLKERNLPLPRPPPDHIPQKRKFEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UYN0</accession>
    <name>A0A162UYN0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_140888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296872.1">
        <property type="nucleotide sequence ID" value="XM_018430475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UYN0"/>
    <dbReference type="GeneID" id="28991381"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_140888"/>
    <dbReference type="InParanoid" id="A0A162UYN0"/>
    <dbReference type="OrthoDB" id="2268828at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="73519" checksum="BC313159BB398CCE" modified="2016-07-06" version="1">MNNYIANASITSLNDESQKSELQKDTREDSQSNNKDFEMDEEECNQEINILEIEIEIDACHKKAAEKLIKVLENPKTKLNNIRKVQEEVANTKERWVAFCDAQEMMSSPSAVELCGGPVCQTNKAVHDSIAAFLNDFKVQLRAHNLDFDQHWECLFWLTCDERQRVSFEKTRARRGLKWKEVCQQLESEHSNPYHLWIKKHEVHCMLQKPGELVRAYVERFLVSVHAANLDSSDELVWLFTFKLLRPHYGLVVPKNIHQVIPLIMATSGEETDFLFQEERTTSGTKRYQEDNHEYTGSKRECGEFCRERCKNNHNNRGSCPLHPKGRHSKDKCHILKSITSTKNKTFTPPAPRPAPLCRYCHKVPYFNGHKCPEFQLAKAKKPVFANCSTRTVNSEDALDSRIELDLSQLNLQAQDKHLNIHHLTAPPHNDGSLYVPIIVQSSWVWALVDSRANTSFISPDLVFSLSLPITKCSSKKQHIYLASENSLAEHLGTVENLSLSYMSHKLNHNFVVMSLALGTQMNIGTDLMPRLGMAITNLATTWDDQKSDSLRENTPDDVPEPNKSPAGTSEKQKQFMEAIEQSIRSNKLIPKTSFCTIHWFLLANEPGKLTISGTVTHQAHVHYTLIQCKPTITQQGFELQGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V0M7</accession>
    <name>A0A162V0M7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_179020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297252.1">
        <property type="nucleotide sequence ID" value="XM_018438083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V0M7"/>
    <dbReference type="GeneID" id="28998989"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179020"/>
    <dbReference type="InParanoid" id="A0A162V0M7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD79212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="153" mass="17541" checksum="A8EAA8BCB92B6C52" modified="2016-07-06" version="1">MVPSYHVWSTECVQSMLMERCTENQLSILHPSQLTASELLFQAYQQVSSLHSLEKDVGYWLSRFCPLGHVKIVTERCKYKGVSPGCVEFFKFVEHLDVRDEPEAKLRCLSKCYAVHLGVSDTCPEQFGIKAFHRYFAVMVNLMPCRVGRNEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V4P5</accession>
    <name>A0A162V4P5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NOT2/NOT3/NOT5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_184978</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297963.1">
        <property type="nucleotide sequence ID" value="XM_018439012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V4P5"/>
    <dbReference type="STRING" id="763407.A0A162V4P5"/>
    <dbReference type="GeneID" id="28999918"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_184978"/>
    <dbReference type="InParanoid" id="A0A162V4P5"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="242"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="163"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="376"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD79923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="402" mass="44322" checksum="127B9E8F5EDFE536" modified="2016-07-06" version="1">MFRQTPGVDLNEFPALGTPPTSNRGNPATTGPMPSGRLASYASTAGTNVNANHLQETLIGNGMAMNDYGMQNSSSMAYQTPPNGFPLPTDQLGRGLGPRSFSVDDFPALRNPDNAFGNAIANEPSPMNGKPEPWREYSGPREGNKQYGAKSGAMETAQWLQGRQDTSLPQLAPGSRKTMESREAGKENENAPSWSEQGEADPYGLLGLLGVIRMTDPDRSMLALGSDLTTLGLDLNTADTIYSTFVSPWSDTQTPPGLNVEPGYYLPSCYRSVKATPDAHMRMRTFSEDVLFYVFYSMPNDIAHEAAAQELYNRNWRYHKELGLWLTKEADDNGRPVSVFRRTPAGAIERGIFSFFDPAVWQKVKREWTLSWDMLEERPPQSQSQPPQQHQGSATANRGVMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V7W7</accession>
    <name>A0A162V7W7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_61756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298743.1">
        <property type="nucleotide sequence ID" value="XM_018440852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V7W7"/>
    <dbReference type="GeneID" id="29001758"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61756"/>
    <dbReference type="InParanoid" id="A0A162V7W7"/>
    <dbReference type="OrthoDB" id="10321388at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22125" checksum="FE26BFE4428E5AE7" modified="2016-07-06" version="1">MFGMRFGLGDQQSVQGMINRPTITIILSLDFQITSVSDEVMVLWGFEPKAFVGRCLSDLVAEDHGRLSHLQHCLTDRTDLHTRTFSDQLVCFDKQWDVVMRRELDMIESKWRQSALQCSSRRVSSPALVLPLSVRPLILHASSCHSGLSPATLSSRPLAANGILSGSNAGRPPPLESLLPDKPRLFYPARDLIRNTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V875</accession>
    <name>A0A162V875_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_161425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298823.1">
        <property type="nucleotide sequence ID" value="XM_018434399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V875"/>
    <dbReference type="GeneID" id="28995305"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161425"/>
    <dbReference type="InParanoid" id="A0A162V875"/>
    <dbReference type="OrthoDB" id="10498254at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007840504" evidence="2">
        <location>
            <begin position="24"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD80783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="455" mass="51136" checksum="48955050E7C0BABE" modified="2016-07-06" version="1">MPRLRRSFGTCALLYISVLECYGLPENTTEDTRATYSNVVAFSVIKAIVFAYLAHSMVIRPSMNTISSGTFGERFLFLAFPTFAGSLVSHHISAAWYGDRSLGIENFKKPLEVYSKTISEEADDNIIHTIAGEPSGSYFGSFSAQNDIELESNPMKANLNMVQQKTQRKSDWLVDYGNKTQEFNIEDHDNATYLAALLQSLGPDKAKKLKHCLLNSSLFVGFDLLDETLLEDLNYIKTDQIRVIGLGVACKYQASVAPSVVRYLPTTMLDQLYDSSSVDRVPYKEVFITLVQLGYTVIECLNPNNENKWIKSVLLVYMIMSMGQTLSILALHTQEFAFSVRYRPGHPKQNISSDNTCTPASDTHLDKDFGCTSRPLEGQNETANEYCDAVIHKGSFLYQVLQGLNIYTNTEEPLDPYEESVWNFFVVVLLFAMPFLLGIWADYASHSTTEWLVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WC83</accession>
    <name>A0A162WC83_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_175507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441005">
        <property type="protein sequence ID" value="OAD66215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018437508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WC83"/>
    <dbReference type="GeneID" id="28998414"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175507"/>
    <dbReference type="InParanoid" id="A0A162WC83"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="448" mass="51655" checksum="01EB43B43D144109" modified="2016-07-06" version="1">MHNLFLGTAKRMMDIWIATNLLDDKDLVEMQEEANRMVLPVGYTTLKIKIGKKFPFMKADEWKSWCLIYSPVLLKTRLRDDLLGNWIHFVDACRELTKPSITKNGIKKAHESLEEFCVGCEDFYKPDVFTQNMHLHLHLKETIEDFGPIYGFWLFSFECYNGVLKGFETNQKSGFENTYMKRFLESSYNGDFCQAHLRNVTSPLLLSLFLKLSGCKIYNPALSPHPLIPSFFHLPTFLQSTEKPSKQTFGNESLPLSALPLCLKPPTTMRKSEYDCRLDFYKIEYDDDSLCSAKTTIRNCWFVNDRIQKISSINLLGQVYTGGEGLVVRGSHIQAKFIEKSGDSEERYAGRIKYLFLHDFTPNLTHTNLFPCHNPQHVFAFVEWYKIPCHQSRIKQGIELYEPEFLKYDYDNILPVHRILSPIAIGSHVSGSGAAKVVVIPLPRKLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WI72</accession>
    <name>A0A162WI72_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_151559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285345.1">
        <property type="nucleotide sequence ID" value="XM_018432703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WI72"/>
    <dbReference type="GeneID" id="28993609"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151559"/>
    <dbReference type="InParanoid" id="A0A162WI72"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="81" mass="9201" checksum="0822C69FECAE4781" modified="2016-07-06" version="1">MQVAQFEEAKLRQLDVLFHEESTIHLTSFITFQIIKAVDDGSLIPPTSLEGPPEILNRAEIQTLNWPVVKILEFTAIFPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162X5L7</accession>
    <name>A0A162X5L7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_169737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290655.1">
        <property type="nucleotide sequence ID" value="XM_018436151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162X5L7"/>
    <dbReference type="GeneID" id="28997057"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169737"/>
    <dbReference type="InParanoid" id="A0A162X5L7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD72615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="466" mass="51796" checksum="A212D83FC94611AF" modified="2016-07-06" version="1">MSVTCGGTRLVFKPVCLWYLPFVYIRGWALVDFLSGLRPRSVSGGFCTSRASGVLDSGSFLGHGGPVGLSGLVASLFCTWVLGLCSLSFVLKPGRMNTVGHGVHYVVMSGRMGFASLPGSFLGSLEGYRQSPPFFSGEYLKIHCIKAKLNIDMNMNMNMNMNMNMNMNMKKRISSIQASKLSSTTSLTSRLQKGIWDVRVYIMDREHQQEQVEAGRPVTGLAILQPFRGYHRELVSVELYQKGSWCGKPRSGSSSAIRWSNPFVIDPIAAIWHIVSVGSLAVYCRWSRIPPAGGQGSFRPVIEEHFAVLSPSLQMMLPIPRQVPLLKKQILSIKTSRIPEMVKPRFAYMFKSNSKSCPSPSPSPNVQALSKHCPIEAHFYQSPKSGLYLQVSRPSRFPRRGPMQNSKSKFQKKNKKQKTKSEAYTKSCKKNGHILSPPFQKDQKKSELEAYTKSSTPKGSNPKPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162X884</accession>
    <name>A0A162X884_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_65765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291205.1">
        <property type="nucleotide sequence ID" value="XM_018441528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162X884"/>
    <dbReference type="STRING" id="763407.A0A162X884"/>
    <dbReference type="GeneID" id="29002434"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65765"/>
    <dbReference type="InParanoid" id="A0A162X884"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF489">
        <property type="entry name" value="RING FINGER DOMAIN AND KELCH REPEAT-CONTAINING PROTEIN DDB_G0271372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="146"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD73165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="415" mass="47862" checksum="414C2808A193A5AB" modified="2016-07-06" version="1">MNKYPDSDTRDSIQKIKVSISIIKSVIQPINKGVSYEPEYRGESSNGRVYFEGTTLQNLQNYITDDQLALSVSLTIGHKNKNPVDEPRSYPKPRPLKFYDQDLKNFQDVTIHVLKNNKDEPKEIESNLNNNSTASITISKNKKDESTQEFVSDKKTTLHGHKFILAAASPWFRDIFLSGIKESTKNEVKICGVDPIISQLIFDFSYGKDIYIKDSTHCINILKVADRLQFKNIKVYAFSYLRNQVKKSNIFGIWEASDLYDCDETRALCEKYRKSGYPDIFMSPGWLSANDKCAISVIKIDGLQGIIDETRFYKAVLARREFAIQTVINLRKAKEKESEEKIAKAPHVTPTPSNVNIYEEIQKEAKDIKEDDKDNSCNSDTQTKTKTERLKRLENIRWENILKRNWKLYKSILKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XAE5</accession>
    <name>A0A162XAE5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_145916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291565.1">
        <property type="nucleotide sequence ID" value="XM_018431561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XAE5"/>
    <dbReference type="GeneID" id="28992467"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145916"/>
    <dbReference type="InParanoid" id="A0A162XAE5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="151" mass="17191" checksum="AA1DD618D5E7771B" modified="2016-07-06" version="1">MAHHLATSPPRHLATSASASTARINFHKTQVFSLSGFPHSRWINTLYSLQTVDYQDNHSPESIRYLGSLVISFLTQCNPFCSQILAMIEHILHILLFSASSIRSRTAVLSSFILSKLLQVFHVLFVPDTFFANAEHLMTRFHQHRSFIPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XDK4</accession>
    <name>A0A162XDK4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_63903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292185.1">
        <property type="nucleotide sequence ID" value="XM_018441199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XDK4"/>
    <dbReference type="GeneID" id="29002105"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63903"/>
    <dbReference type="InParanoid" id="A0A162XDK4"/>
    <dbReference type="OrthoDB" id="2283182at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="156" mass="17923" checksum="7BE1CB26D458EE22" modified="2016-07-06" version="1">MSPTHLLHCQFFMIWQQTCLLENNFRKDLIAQSLFRIARGFLKQSIRCEIELLDTLASVCNTGIQHYLRILNTLKCALKTWIAKCPQTIVDAKGTNEERKLIAHAQCLFDQQQTNIHGDISIYDKDNSSEKKGISLQAKCIIIKIQRDISIESSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XP95</accession>
    <name>A0A162XP95_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_142960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294015.1">
        <property type="nucleotide sequence ID" value="XM_018430907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XP95"/>
    <dbReference type="GeneID" id="28991813"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_142960"/>
    <dbReference type="InParanoid" id="A0A162XP95"/>
    <dbReference type="OrthoDB" id="2290427at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="225" mass="25145" checksum="35F1AB6D889871DC" modified="2016-07-06" version="1">MLSETQTRSLVSFRNYNLTSSEDRMGLNGQPPLVSMETLSGLFFFALDEMHGLCHGIGKQVWELVREEYELKHHICLSLATQREIGTVIVAIKFAISKLLHGASRDMTKNASFFKAVNWANFLLFVVPTLVAECVQNLVAQNNLVKWNLFLESLLSTADIDIGVFTINQHIIQHYLKMVDLYASVNTENIMIRLAQFQSVAELTTVASTKTLPANLLAYSACCVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XTK8</accession>
    <name>A0A162XTK8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Calreticulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHYBLDRAFT_123686</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 14">Belongs to the calreticulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294475.1">
        <property type="nucleotide sequence ID" value="XM_018428943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XTK8"/>
    <dbReference type="STRING" id="763407.A0A162XTK8"/>
    <dbReference type="GeneID" id="28989849"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_123686"/>
    <dbReference type="InParanoid" id="A0A162XTK8"/>
    <dbReference type="OrthoDB" id="1938156at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000002">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009169">
        <property type="entry name" value="Calreticulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF2">
        <property type="entry name" value="CALRETICULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002356">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 11 14" id="KW-0143">Chaperone</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007747952" description="Calreticulin" evidence="14">
        <location>
            <begin position="19"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="363"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>an alpha-D-glucoside</name>
            <dbReference type="ChEBI" id="CHEBI:22390"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>an alpha-D-glucoside</name>
            <dbReference type="ChEBI" id="CHEBI:22390"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>an alpha-D-glucoside</name>
            <dbReference type="ChEBI" id="CHEBI:22390"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>an alpha-D-glucoside</name>
            <dbReference type="ChEBI" id="CHEBI:22390"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>an alpha-D-glucoside</name>
            <dbReference type="ChEBI" id="CHEBI:22390"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR002356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR002356-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR002356-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAD76435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="446" mass="50222" checksum="23AADA486B662A25" modified="2016-07-06" version="1">MKIFTIATVLGLASLASAEIFLHETFSDGENWTQRWTPSTHRADLGKLEVTTGKWFADENKSNALRTTEDYRFYATSTPIKPFTNKGKDLVIQYDVKNEQHIDCGGNYVKIFSDKFDPKTFNGDSEYNIMFGPDFCGTKAMVHAIFNYKGVNYDLKKTVSAPNDVDTHTYTLIVKPDQTYQILVDGEEKASGELIEDWDFLGPKTIKDPSASKPADWVDEHEIDDPEDKKPIDYDSIPEFLADPEAVKPEDWDDEMDGEWEAPSVPNPDFKGPWAAQRIPNPDYKGPWIHPEIDNPEYKVDNEIYAYTFGNLGLDLWQVKSGSLFDNFLVTDDIKEAEAIRQESLDLAVKEKEAKAVHEAELAKAQEEADAEQAAVGTEADDKPLEGGESGDMEINFDELNFDDEINLDEAAAEVKENVAEIKEEVEQKIIEAIPEAAKKPVKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XUA7</accession>
    <name>A0A162XUA7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cytosolic iron-sulfur protein assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CIA1</name>
        <name evidence="5" type="ORF">PHYBLDRAFT_177037</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294575.1">
        <property type="nucleotide sequence ID" value="XM_018437848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XUA7"/>
    <dbReference type="FunCoup" id="A0A162XUA7">
        <property type="interactions" value="267"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162XUA7"/>
    <dbReference type="GeneID" id="28998754"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_177037"/>
    <dbReference type="InParanoid" id="A0A162XUA7"/>
    <dbReference type="OrthoDB" id="284782at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000136">
        <property type="entry name" value="Probable cytosolic iron-sulfur protein assembly protein CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="10"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD76535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="327" mass="36554" checksum="0C1E701418C38A14" modified="2016-07-06" version="1">MPHLELLATLEGHQDRVWQASWHPTKTLLATCSGDKTVRLWAPATPTDFTKWVCVDTLKGAHKRTIRSVAWSPSGNEIATASFDATTGIWERDPQIADWECMATLEGHENEIKSVAWSSSGALLATCSRDKSVWIWEVESDNDFECLSVLQEHSQDVKMVAWHPKEEILASASYDDTIKIWKEDEDDWYCADTLHGHASTVWSLDFNAAGDKIVSASDDKTLKIWKQDGGKDGSWTCETTLEGYHDRCIYSVSWSKIHGLMASASGDNTIQIISKDGEAGYRSVAVMQDAHGVHDINGVAWFPTQTHQDWLASVGDDGLVRIWRMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XWS9</accession>
    <name>A0A162XWS9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_165428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294975.1">
        <property type="nucleotide sequence ID" value="XM_018435240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XWS9"/>
    <dbReference type="GeneID" id="28996146"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165428"/>
    <dbReference type="InParanoid" id="A0A162XWS9"/>
    <dbReference type="OrthoDB" id="1858323at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="33122" checksum="1D0282A9BBAC0977" modified="2016-07-06" version="1">MSNINNTNDHVIVSETSSKKKMHDKENWVNTYVFKHPHFGNRTSNRAKSSHASLKYALGTSSGKLKTVTMKVVKWYEALFDDRKRRLTMECLGESTTVVFDKINSFRLNDIHHKICRFAMDHIKLELAKSIIPEKLTKECECLINYNYLLPCYHQLAQYKKIPISCIPRQWRINYLEGEDHSIIHNALPVPKNITKITTITPQLAYKLERVTQILTNAQSKQQQIHFKEYIDKIIELDSKQKLENLNGLTVVEAIKDRPKNTKRKMIALEHCLEAEKEETTKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y083</accession>
    <name>A0A162Y083_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_76411</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295565.1">
        <property type="nucleotide sequence ID" value="XM_018443150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y083"/>
    <dbReference type="STRING" id="763407.A0A162Y083"/>
    <dbReference type="GeneID" id="29004056"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_76411"/>
    <dbReference type="InParanoid" id="A0A162Y083"/>
    <dbReference type="OrthoDB" id="5546837at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36460">
        <property type="entry name" value="UPF0132 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G10255)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36460:SF1">
        <property type="entry name" value="UPF0132 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G10255)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD77525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="194" mass="22104" checksum="E579653E4172E8DF" modified="2016-07-06" version="1">MNFSPYKPSPDEDRNNRLREERQKQKQPKGKAKQTDTSPYSSYQSGKPNYPGPSPSSLEEGLFSETDNLGGSRGPPTGTLRVNKYETSLPIRVDIEAALAYVLGPVTGLLFLVLERQNDYVRFHAWQSSMVFLALMCAHFVLMFISNFLSWTLFIFDIGLLVWLTYRAYLDGASLERYEFPYFGPIASEYVDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YG03</accession>
    <name>A0A162YG03_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_61496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298485.1">
        <property type="nucleotide sequence ID" value="XM_018440811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YG03"/>
    <dbReference type="GeneID" id="29001717"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61496"/>
    <dbReference type="InParanoid" id="A0A162YG03"/>
    <dbReference type="OrthoDB" id="2284562at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD80445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="427" mass="48479" checksum="A99ED62990FB193A" modified="2016-07-06" version="1">MLTRLPNELLDVVLGRLEYDDLDTLSTLESLRPIVQHHLNQHFHYHCTIASLLRSFESLGVDERRDHEMRSGLAMELLQFICHIVENHEQQNRQTTFTDLLDTLQKLVTRRILSPDLQVGLEQDYASLCLEVRRTYMHTPAIRVLHDYKYRRRSTKYPLAPFLPRDYAWLWRAQCAKVSELLKTNDYRAWASTREVHVRFAHFFGCLFEVTSLYLESNISGTFEECVGEALVSGNVESLLVLCVAAEKPVDVDDMCMMVTQAGEEFWSYLDTVNVLFPHAEPATTTMTTVTAEINTNTVITGATPGVTPGDASREEELMAGGSLLVPAIVSAAAALSAISAAEQAAAARARARARARTRTRARVITRETQPQSLHEPLEPLEPLEPHEPHEPLPDWMIADRYKVTADARLRLKLMNGLFNKGWHWFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZR27</accession>
    <name>A0A162ZR27_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_150120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286571.1">
        <property type="nucleotide sequence ID" value="XM_018432406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZR27"/>
    <dbReference type="STRING" id="763407.A0A162ZR27"/>
    <dbReference type="GeneID" id="28993312"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150120"/>
    <dbReference type="InParanoid" id="A0A162ZR27"/>
    <dbReference type="OrthoDB" id="2289470at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="274" mass="30596" checksum="EF5414FB73F2EDBA" modified="2016-07-06" version="1">MFSDKTGPDGFEYVYISWSRCIMHSEVCCSLRTLGVDTGRLLDINFPARGVIGVLVYVQYLEEFKSQIACAKVSLIDSFDPLDPKNVADPKFANLSLSGLETQTLVLQNACCSQALKFLCPHLVLPVAHFFIQSGWIDIKEISAHPIAENFGLWNANGLLPRAIKDVLNHCQSLHMLFITETWLLSPACLPTSWSQYHLYRSPVVGNYHGSMGVLLLVSPSCSYAVTQIPMPNNYALTVKIGTLRLICLYLPPSMPTHEALDILSHCKRRMHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZWH7</accession>
    <name>A0A162ZWH7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Translation associated element 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_135651</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287531.1">
        <property type="nucleotide sequence ID" value="XM_018429737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZWH7"/>
    <dbReference type="FunCoup" id="A0A162ZWH7">
        <property type="interactions" value="543"/>
    </dbReference>
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    <sequence length="248" mass="27712" checksum="6B6EE6689B347F16" modified="2016-07-06" version="1">MSIDQSTEDNLELMRQPDWYDNAQKYWTAVSPTVNGMLGGFETIDPIDVKGSLSFVDEFVHGVRGVNNVVRKEPVMDSGYACDCGAGIGRVTKNFLLKVPFQKVDLVEQAPNFVEQAKESYLANEIESGRVGNIFCMGLQDFTPEKGKYDLIWCQWVLGHLTDDHLVAFFKRCIKGLKPNGMIAVKENNASREAIIDEEDSSVTRPNSSLKHLFNEAGLSVIKEEVQNGLPAGLFAVRMYMLKPNRQA</sequence>
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<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163A0Q2</accession>
    <name>A0A163A0Q2_PHYB8</name>
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            <fullName evidence="16">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
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        <name evidence="14" type="ORF">PHYBLDRAFT_96053</name>
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        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
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                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="15">NRRL 1555(-)</strain>
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        </source>
    </evidence>
    <sequence length="1343" mass="151033" checksum="81EE19B233D71C35" modified="2016-07-06" version="1" fragment="single">MNPLIYFGISNELTRENIYALTYQHLARFAFAEFCETLVSTNRKKILLRIYKANTGVIWAQFIFSTAAMLVGYLSPYFQQKLLEYIADPQGRPINVTYIYVLGMFGVGLTKATFNGVQLWAGRRWNVRTFAMLDAEIYAKTLKRKDMSGKIAKEKPEGEEEKDEDTKKPFSNTGKITNLMSVDADRLADTPSYIFMLYNAPFEAVLTIIYLYQLLGFAAIIGLSVMVIFFPFTAYISKVMTQIFKDYSTAKDKRNDIVNELLQGIRMIKYFAWENNWKEKVMAARRFEIKKLIRAVTIQVVFFVTYLTVPVLVSCSSFIWYTKVAGNELTASVAFVSITLFEMLRSPLVLIPELITTLTECYVCLKRIASYMDEAEVGDGIINEPIPVPEGVLPETILARVGTEESVFRWHSGEPEAKDAVAAEVDPDEHPDFSLKVPAFEFPTSELSIICGPTGSGKSSFLHAILGEMDIVSGRVYLPSKTKLALDTYSVIDPEYPSLALNKVAYVAQQAFLQHASIRDNILFGQEFDPVRYKKVLSQCALVKDLSILPDGDRTEIGEKGISLSGGQKQRVSLARAVYSHAKTLLLDDCLSAVDAHTAKHIYQRCIKGDLIKGRTVILVTHHVRLCLPAAKFVMKLERGSVTSYGSVESLRENGSLVTILGEGTNENEAADEDEPIEQVDEEFSLIDDNAEVNNMIKEEKSEKGQVKFKVYKTYFTACGGWFFSFALLSSLFIARAFSFGENWWLRIWVANSAGSTNPNAFLTSTAAPVVYNIMSHVNEVTKNQNVFRAWVYEDDQPRSVDYYILVYLIICLAAILFDFLRNIILLWGSIRGAKILFERMVHKIIHAPMRFFDTTPIGRILNRFGKDVMTVDMNVARSASHLLDCITGFIASIIVVGAITPEFIIVAIVIGVVYMVIGVVYLRVSRQFKRLNSVSRSPIYSHFTETLTGVITIRAYCQEEKFQLELYKKIDGFISPFYLLWMSNRWLYARIEFAGAFVSFFAGAFIVLNLDTIDAGMAGISLFYARSFLENIYWIIRQYTQVEMDLNSVERIQEYLEIEQEPPASIKGSRPPAAWPTTASVEVKDLVIRYAEDLDPVLHGISFDIRSHEKVGVVGRTGSGKSTLALSFFRFLEPSSGSIILDGIDITHIGVQDLRSKLTIIPQDAVLFSGNIRSNLDPFEEYTDSAVWESLVRAHLAPENRDEEVPEGNATWAVTSLSQTVSDGGNNFSQGQRQLLCMARALLKNSRLIIMDEATASVDFETDKKIQNTIREEFVNSTLICIAHRLRTIIDYDRVLVLDQGNVVEYDTPANLLINGAGTGLFKSMCEKSGEYDVLIEMAHQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163A8G4</accession>
    <name>A0A163A8G4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_147521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289801.1">
        <property type="nucleotide sequence ID" value="XM_018431883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163A8G4"/>
    <dbReference type="GeneID" id="28992789"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_147521"/>
    <dbReference type="InParanoid" id="A0A163A8G4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="277" mass="30900" checksum="4F10CA9494D1FE9C" modified="2016-07-06" version="1">MSSNTQQSKKTKKTTTTKSVQQTAGTAASTRQREILPSLTVSAELDGTVLSTLSTMSTQLNESHSLLEKVYHNIGATNGQNNNSNHSPIGQALTTGEYIKYRLPTVLRLIRSQTRAVLATMPLTVNEGAFSTSNRPIADVVQSYTHQQAEGKSFARKDSLTKSDFLTPVQKEKHYKAIHLADKANLESKFGETVVDLLDYDMLSDIESDEEKNKTRYTPRNRHPLVDEYFTVLKKQRLANKGPDVIGNSVYSIILRNTELSNEKKARVAAWIHTCQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AG62</accession>
    <name>A0A163AG62_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_168626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291311.1">
        <property type="nucleotide sequence ID" value="XM_018435907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AG62"/>
    <dbReference type="GeneID" id="28996813"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168626"/>
    <dbReference type="InParanoid" id="A0A163AG62"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="136" mass="15924" checksum="9F4350DA83B17F40" modified="2016-07-06" version="1">MVLYNNNKNIVELKDQGGLNLFLNFSLRRSNHHKPYEIEFFDCRFEYYSPQTSFDQKMDIKVVFASFVICHFGHVYKRTLALLKTVLSSLGVILSKEDRKIGRGLTNWSGLNSGSRFYRVWIVMYGLVVSRDQDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BGK1</accession>
    <name>A0A163BGK1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_139003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299491.1">
        <property type="nucleotide sequence ID" value="XM_018430128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BGK1"/>
    <dbReference type="GeneID" id="28991034"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139003"/>
    <dbReference type="InParanoid" id="A0A163BGK1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="106" mass="12534" checksum="87C253CEEEC3E610" modified="2016-07-06" version="1">MSKHENKIQQRVWVYRSPFLSHTHTYGEYRAIASIHRIRSTRKDGHKIREKHVFGHASQPYTTLGWMFSDLCTYGLRPMMTKHFRLITGLELGSLYSARGFWHLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BH52</accession>
    <name>A0A163BH52_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_73453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299601.1">
        <property type="nucleotide sequence ID" value="XM_018442859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BH52"/>
    <dbReference type="GeneID" id="29003765"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73453"/>
    <dbReference type="InParanoid" id="A0A163BH52"/>
    <dbReference type="OrthoDB" id="2302687at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007841767" evidence="1">
        <location>
            <begin position="18"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD81561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="215" mass="25157" checksum="05D47BB184A90CCF" modified="2016-07-06" version="1">MISVIIQMLSVMQHLLSMLGLLSIKKDFRKITAEIRKTGSGELPPQERYIHFDNMKEITLSDPSFFPSMLMETDHVVDEVVAEAVISICYYDDTEPVLTTGTRRTMPSELQQAFLKNSRSQNDIMASMHKLLSTRYQIFEELYEDTLQQYRLDVTAPQEARRLDWESRELIATCEYNRRVIADEREEELRRSLLEIFSRCKRSRSPLSSLTHINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163D183</accession>
    <name>A0A163D183_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_68359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286030.1">
        <property type="nucleotide sequence ID" value="XM_018441935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163D183"/>
    <dbReference type="GeneID" id="29002841"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_68359"/>
    <dbReference type="InParanoid" id="A0A163D183"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="100" mass="11101" checksum="38C124AC094EC5BF" modified="2016-07-06" version="1">MSSYKHVNNIHNMNDTDNIIESLLLAIQLQLSVLHANQEQIKMDINSLGNEIMIKESPKQNLSLFINISPDVIKIGHPLQESVISGKAVKGGNLQLCLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163D8E7</accession>
    <name>A0A163D8E7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_159778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287550.1">
        <property type="nucleotide sequence ID" value="XM_018434060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163D8E7"/>
    <dbReference type="FunCoup" id="A0A163D8E7">
        <property type="interactions" value="1240"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163D8E7"/>
    <dbReference type="GeneID" id="28994966"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159778"/>
    <dbReference type="InParanoid" id="A0A163D8E7"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="538"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="112"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD69510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="632" mass="72378" checksum="1FE37F09CB3BCB72" modified="2016-07-06" version="1">MRLFVTKRAYVFAPETGPNLTINRETSEISLMDAIPPVSEQDRTLAVAGIMGLVTLQAGDYLIVITGRESIGNIRGHEVFRITAFQILPLPESLTGLSEAQAKDEQTYVDLLEAHLRGTTFYYSNTYDLTHTLQRQAQFTTETLSEPLWKRADERFFWNKDPVNRLIEATLSGNPAKNFSDFILPVLQGFVELQATEINNKPFVLALITRRSRHRAGTRFFSRGVDQHGYVSNFVETEQLVLYDGPGAVSSSPGLKQLSYVQTRGSIPVYWTQVINLKYTPRLWVGENRKSLSAARSHFDEQIRIYGPQILVNLINKKGYELPMGQAYARTVEQLNDPRLYYTHFDFHSECKNMRWDRINILVDQLKDQFDQQGYMYYDASNKDSLIIRKKQNSVIRSNCMDCLDRTNVAQSTFAKAVLNAQLREIDILGANESVDDHPNFILIFRHVWADNADAVSSVYSGTGALKTDFTRTGKRTVPGALKDLSNSITRYCKNNFMDGKRMDAFDLFLGHYHIKPLVATGKYKSPFVSEKPLRIRVVPYILVFSMFMLLLNIFRPDYSGFEFRRAYFLWLSFWFSVVVTASRFSLRHGDQFVEWPHLVELPPYEDDAEEGVVENKGNMVPPEFGLETPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DFS1</accession>
    <name>A0A163DFS1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_63991</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288980.1">
        <property type="nucleotide sequence ID" value="XM_018441217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DFS1"/>
    <dbReference type="STRING" id="763407.A0A163DFS1"/>
    <dbReference type="GeneID" id="29002123"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63991"/>
    <dbReference type="InParanoid" id="A0A163DFS1"/>
    <dbReference type="OrthoDB" id="2283980at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="152"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD70940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="276" mass="31845" checksum="2672837A1ABB3396" modified="2016-07-06" version="1">MTSPAQRSRHRSVCKRLVLHKLSRKECISHFHFSFEDIQRITNALGMDETCNFPGIKIEQNLGLAILLNQYSFPRHLDDMAHYFGINAQNISRVCREMEDLLFEKMRWGMQFDICHFSPSNMERFSKAIFDKGAAFDNIVGFIDGTMQTYIYALKFQTIVTPDGITSSLLGPFIGSCHDYFINTISKIEDRLKKYLAPTSDPEKYYALYGDTAYMCSVHLYSPYLGAVLNDHDKFCNKSMSKVRVAVEWEFEELPLSLEDYISGLTRDKIEGEDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DGM7</accession>
    <name>A0A163DGM7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_114655</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289140.1">
        <property type="nucleotide sequence ID" value="XM_018428407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DGM7"/>
    <dbReference type="FunCoup" id="A0A163DGM7">
        <property type="interactions" value="269"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163DGM7"/>
    <dbReference type="GeneID" id="28989313"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_114655"/>
    <dbReference type="InParanoid" id="A0A163DGM7"/>
    <dbReference type="OrthoDB" id="6745403at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010045">
        <property type="entry name" value="DUF850_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="236"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD71100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="274" mass="30527" checksum="30F9B966C7B4EEEE" modified="2016-07-06" version="1">MVLVGILRHHITMLITSAPKAPQLKAIRESKALLRGMRLRTFGNSIPQHAFACRKAYLAQAFEAGKYLKNPDAGKEGTPAPNPMTDPDMMEGMMEGMKKQMMNMVPQMLIMGWINFFFQGFVVIKLPFPLTPRFKSMLQSGVDTRDMDVTWVSSLSWYFLNLFGLGSVFSLILGDNNDMAAMSSMPGAMPGMGAPGQQQDFNKLFLAEKENILITPHAWDLENVEERLLKKYGKTVKKSITSSGSSPSANPVKKDSSMREKVKGVQNKGNSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DYQ4</accession>
    <name>A0A163DYQ4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_133256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292280.1">
        <property type="nucleotide sequence ID" value="XM_018429557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DYQ4"/>
    <dbReference type="STRING" id="763407.A0A163DYQ4"/>
    <dbReference type="GeneID" id="28990463"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_133256"/>
    <dbReference type="InParanoid" id="A0A163DYQ4"/>
    <dbReference type="OrthoDB" id="245697at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17742">
        <property type="entry name" value="BRCT_CHS5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13945">
        <property type="entry name" value="Chs5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031673">
        <property type="entry name" value="Chs5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052827">
        <property type="entry name" value="CHS_Export/Cell_Fusion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031669">
        <property type="entry name" value="Fn3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351:SF1">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16892">
        <property type="entry name" value="CHS5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16893">
        <property type="entry name" value="fn3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="76"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="163"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD74240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="29138" checksum="209BBB963BE717B9" modified="2016-07-06" version="1">MTSVQFTVGKLDAGMAILLTEDHHLIEFPSLLLPNGVTSGSIVNIAVTRNVSEEEKKMQEFWDLQEKILMEFGNAEPERPVLRVKNITQTSLLLEWDPLVLHTATLRSLSIYKNDTKVTQHVQSEQNVAKLSGLEVDHEFEFYIVIKTTAGSYESNRVVARTHRMENLTGIRVAFGMFEEPEPAITELKALVEKMGATWTDEVNSETTHLLAQLPGGPGYDQAVRYSIPIVKPDWLVQCNKNKKIQPALPYYIRQLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163E7F7</accession>
    <name>A0A163E7F7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_165631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295180.1">
        <property type="nucleotide sequence ID" value="XM_018435267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163E7F7"/>
    <dbReference type="GeneID" id="28996173"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165631"/>
    <dbReference type="InParanoid" id="A0A163E7F7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="402" mass="46742" checksum="53B3E2AEEF3034C7" modified="2016-07-06" version="1">MQNTPGADHPEEPDLPEVTEEDIKTFGCWETSNLKNGVLFCLCEETYKNNLGYPLANALANAVQEKFPDDALGALVRHKIWRGDRDEKRYIIEFAFDSDIPRSILKNEGIQAKNKIRFPLFTHPFVHRFRRFRITQLPIIRKDTLKTHIKRFMGPFGNVIFVKFEDGPIGELFGGNAWIMLYIHTLDKKEPNIIPNYIVYSDDEGKEVYLQIIKNFGCRVSKTQKNGVVFCTCNSWPKKRQIAKEIKSKFPENILGVLEQNMNLNSPSANQNSCLEFAFNSDMPRAHLRRTGIKVKFSTIFPLFTRPHIHIFHEVQITGLPLIERDTLKRHITQFMKEYGKVSHIRYYDEYKSDLFEGRALIIVYINETDGKKLDDLLEEIIYSDDEGKNISVEVKKTLYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EBZ3</accession>
    <name>A0A163EBZ3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_60988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295900.1">
        <property type="nucleotide sequence ID" value="XM_018440728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EBZ3"/>
    <dbReference type="STRING" id="763407.A0A163EBZ3"/>
    <dbReference type="GeneID" id="29001634"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_60988"/>
    <dbReference type="InParanoid" id="A0A163EBZ3"/>
    <dbReference type="OrthoDB" id="440781at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16118">
        <property type="entry name" value="UBX2_UBXN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467:SF1">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="96"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD77860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="240" mass="27110" checksum="FC1FAD8C53556165" modified="2016-07-06" version="1">MESPTINEHVPQVQADQPVEPVTIPTVPETPNREIKVFNPPANAPPPAEVPESFYKLDANEVGRLYKSQVDNRQKMENAPLRTQKMRTTEEQERMKKYPRTTIRVRLPDGTILQAVFQSKEKVSALYTFIRSTLETPDRQFLLCLPPRTKLVDPDLTLYKANLAPASNVMFVWIEKATGSDTQVLKKEYLDMKQPLASSSASSSSPLASQDPAQQQQPKPTPPVKTSKVPKWLQKGLYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EKE0</accession>
    <name>A0A163EKE0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_85838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD79080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297120.1">
        <property type="nucleotide sequence ID" value="XM_018443625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EKE0"/>
    <dbReference type="STRING" id="763407.A0A163EKE0"/>
    <dbReference type="GeneID" id="29004530"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_85838"/>
    <dbReference type="InParanoid" id="A0A163EKE0"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000808">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD79080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="206" mass="23378" checksum="ABDE51470DD4CDA8" modified="2016-07-06" version="1">MLSTLEAKVVILGSQGVGKTSLVTRYISKTFSPNSTSTIGASFMTKKLTVDNCKVRLQIWDTAGQERFRAMAPMYYRGAQAALLVYDITSHESFREMHSWIEELKRNMNEELVIVVVANKLDMAATRREVQLEDAREYVTRVLGPDTPLYEVSAKEDDGTIEDIFLHITRVLVDRKQYLPRDRRMQPSKTLVDEPPAQQTSCCGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EML2</accession>
    <name>A0A163EML2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_179126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM20/NAA25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297570.1">
        <property type="nucleotide sequence ID" value="XM_018438106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EML2"/>
    <dbReference type="FunCoup" id="A0A163EML2">
        <property type="interactions" value="680"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163EML2"/>
    <dbReference type="GeneID" id="28999012"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179126"/>
    <dbReference type="InParanoid" id="A0A163EML2"/>
    <dbReference type="OrthoDB" id="1874341at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF3">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="966" mass="110555" checksum="680554078B06F885" modified="2016-07-06" version="1">MKVPALLDTKDRVGSYLSHRVLSPYRTATMRGSRFPQKKVNVRCSSNIGKAVPSPDSTRLGLQIGNRNMALDYATEKKLRPLYEAIDDCQYKQALQLVTKMLKKTPDWPLIKALKALVLVRTGKENEASELCKQVKKTIPADDATLQAVTMVYKELGEHTSIVELYESAANSQPKNEEFANHWFMAMVRSSDYKGQQQAALKLHRTFKSNKYLFWGIMSLALQGEGGSSLSYMLAERMMAKAQEEGRLEEVEHFRLYLLILLDQKKHEEALALFDTPLGEKSLRDPEVRQMKTELLSTNKKWSEVLAASEKALVHENADDWINWLAYFDAVEALVAEDNKEVVNNAHQLIEKLKKSALEAPMMKRGPFLAELEFEYRLAKKQDQGHDQSNLLQNIVTYFAQFGSKSCCFEDLQNYTSYLKLTPEKAKGFIQSLKDTIKETGEKAGKVKNIYKDTNIRKLERFLGLQSQLSLKEGIELVNGLWKAYEDALPLGKGLEKTEYQYGDEYVILATHILLDLYHEHNNTSLLIQAVSLLEIALVKSVSNFQIKLALVRLYAILGIYTRIEQIYLTMEIKQIQFDTMIHYFTDKLFSLGCLDEIEQSLYDALVIYKSNEVETPEMLVKAYQFGTFSKIQEFIEFRNRLDTSLQHSISLVELIRIDAMNATFQIKNGVQFFHDLDVSKIKFDDVFIDSRSDNRDFKVFMNCNSKEIQSAQELFKPTISTNKTWVQMFSYVFNILSAACDTKGVKDLDSVVKQFTEFLGRESIQANVTCQEYWLAKYVSDLSNALVLSKSSVKNADNSKKIAGFLKDAAEIMEKHVIETRPYTTETISWVDFHKTNTVLEVFNYGSVLLEMLNRSLGLTSKDAKRKAAENKVDEVLMNLTALQAIAKKSMVTVQTNVKTGKDLFRIQLQKKLIKEITNSEVVLDYFKTKEAQTVLNDHLKIMVTSWALSIERYTDEVNKRILKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JMR3</accession>
    <name>A0A167JMR3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_160650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441004">
        <property type="protein sequence ID" value="OAD66328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284368.1">
        <property type="nucleotide sequence ID" value="XM_018434222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JMR3"/>
    <dbReference type="FunCoup" id="A0A167JMR3">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167JMR3"/>
    <dbReference type="GeneID" id="28995128"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160650"/>
    <dbReference type="InParanoid" id="A0A167JMR3"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="150"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD66328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="392" mass="43909" checksum="ED0BBDC4BF37265C" modified="2016-07-06" version="1">MSSSSTSTTTISTTNTMHTTTTHLGSPPSHWSSTLSDGVGSLSASKNYSPPYRPFAPAESPQPVSIVFDSNVHFVSLSSLESGLSTKSPTKPAIVSPSLKDNNITVDPQKWLYEYGAERERDRQWRQHYVLKMVFGGNLKVELDQQPKQILDCGCGVGLWTLEMAQAYPGAKVIGLDVVLPITGGVSLADFEENQNGVCVAGLPNLKYIYADLLSPLPFPDNTFDLINQRDVATVVPAKYWPDLVKEFQRVLKPGGKLQLVEYDILFKSPGPVLALVNEWYKIAASMIGVDPHYVQSIEPLLQKTGFEDVEETVYSIPIGEWPDDPTKKQQGYLYKEQIKALFKSMRKWWLSEIRVTSEEYERVCLGALDEFEEHENVAEWRIFTARKPLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JQP5</accession>
    <name>A0A167JQP5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nuclear pore complex protein NUP96 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_189269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441002">
        <property type="protein sequence ID" value="OAD66517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284557.1">
        <property type="nucleotide sequence ID" value="XM_018439631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JQP5"/>
    <dbReference type="STRING" id="763407.A0A167JQP5"/>
    <dbReference type="GeneID" id="29000537"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_189269"/>
    <dbReference type="InParanoid" id="A0A167JQP5"/>
    <dbReference type="OrthoDB" id="3797628at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021967">
        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12110">
        <property type="entry name" value="Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear pore complex protein NUP96 C-terminal" evidence="1">
        <location>
            <begin position="132"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="574" mass="65566" checksum="7D2EC3AE04FBCF3A" modified="2016-07-06" version="1">MSSIKASHNESVASIPKKRKPTETSFTVDINIYASTIRFVQQHWLMEIPKGLLAHPKYCITDTLLNDLGSQNKPPNLSEEEYKAWEILEILMNTHSKNLANRFNRWFSSDTAQIQHLLAKYEDKHSGDPWAAVLILLSCRKVTQASKIAQELGDHDLASLLVESEKLNVRQNAQGKVKQLQLRGTFKELTGCHQKIWCALGGQLGYCAVTETVIVEDMDWMLVLGLHVWNGTCASQTLYHAIQLYNEALAYLPGIHNILSRKKTALPPSNCLWVGVLRLWASNMPNMAATKERKKRRSTDWNTLSVDEWPLHFVWLLTLLRSDWFSSDEIYQCTRRWCNALCEVGLAEESVFSALFLKDEASREALIKTILNSRELKNEGYILNELYIPRSWLYQAKATRAHLAKDYATEADYYFEANQFSKAKYTIINHLIPAHMFNNENGLVSRYLSKLDLYGDKDNEGDILLNSYKLIESLPKKIDTAVDDPEATKLLKDDIHFTIKSLKEVQASCAHEDNLVFFIHRICGNLLKLAAGFNDHVFLEELITATPLTPEDCQLNIKEFSRCFLTSFINQACI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K1I5</accession>
    <name>A0A167K1I5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_152002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD67060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285100.1">
        <property type="nucleotide sequence ID" value="XM_018432805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K1I5"/>
    <dbReference type="GeneID" id="28993711"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152002"/>
    <dbReference type="InParanoid" id="A0A167K1I5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22412" checksum="4E230F859358521F" modified="2016-07-06" version="1">MNNTDNNSISLLHAMYNEILSLKAGQEKAKLEMKAQIEELKLEMKTSIKDLNLEITVLQSQLENRNISNQHTSPSVSAISSANTICKPVSIFREITLKHIFKMISEDLGIEVTSNEKATLNMCTKLICDDMAAHPSVIALGPNPSWGSIPVALKKEMCARHANIMKDSGIDFTRCLGNWASTARVAHLWRDRHKRLQSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K853</accession>
    <name>A0A167K853_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_79452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285498.1">
        <property type="nucleotide sequence ID" value="XM_018443466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K853"/>
    <dbReference type="GeneID" id="29004371"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_79452"/>
    <dbReference type="InParanoid" id="A0A167K853"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="159" mass="17543" checksum="955EF91A3989F25D" modified="2016-07-06" version="1">MKKLADSSAGAKYSFILIPSFQSPYLACMQFENPTVFKTSAIVGGSVSLCISLVFGHSSSPVTRAVPCLYPTIVAQHSIRTPTTIEQYTRFNLDCKHTQYLSTSIDTTKEAPVFEVLSQHIFVSFPFSACHLSFCLLVGWSVVWNTFIVSLVAPFFVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KA39</accession>
    <name>A0A167KA39_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_86154</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285616.1">
        <property type="nucleotide sequence ID" value="XM_018443636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KA39"/>
    <dbReference type="STRING" id="763407.A0A167KA39"/>
    <dbReference type="GeneID" id="29004541"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_86154"/>
    <dbReference type="InParanoid" id="A0A167KA39"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054295">
        <property type="entry name" value="CHS4-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF16">
        <property type="entry name" value="CHITIN SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22997">
        <property type="entry name" value="CHS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="987"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1014"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1040"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase 4-like" evidence="12">
        <location>
            <begin position="311"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD67576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1113" mass="124421" checksum="DFFE0723B1D5C386" modified="2016-07-06" version="1" fragment="single">SENNNKPKRNKSLVRPERERIDENHRQYHYRQATINRGSEKVSASTTGNQPQILERRPTQSRSAAPIRRGRSILGREERVLDDEAEEQKEHEKNQQQNQKNRGCTSGLPGPWVTYCHLITCCVPKPMMRLMGIPDGPAQMAWREKIGLVSCALLVMGFVGFLTFGFTQAVCPLAPTSVRGGQISPGYLIVNGWAYMLSDWNEHPAVPGIVNSSSNVLYSALNGGGMDASFLFQQPDRMTQCATILTPLQTAPVSGYFPCQLFNPNNTSPPDPSSFTNTTQCHSSAAISSLNTLYTQGVLDNKGTYEKPARVYYEWEDVNTTSHFMVYNNDVLNLMLLQSLPRDYFSFPTGGLIEAILQDNSLFGGKDMTRHITAYREPGNRWQEEAECLKATIKVGSLNTISIGCMASEIVLYVSLVVILSVIGVKFILAVIFGWFLSWKLGNFNEGNSYAARMKRETEIENWTRNIDASAPLGKPRTLPSVYGTPNNKRKTLFPQTSRFTQPEHGSTRFAVEKGPTPSWKAPASSSFGYQSRPSSSYIGSPNPSGRFYGDAPSSVRLSGFMSPMRPSSIYSDFYSNASTNGGAPCPFPLSPFVAPQPSADYMPFNFPLAHTICLITCYSEGEEGIRTTIDSIATSDYPATHKLILVICDGMITGHGNSRSTPDVCVDMMRDLLVPADEVEARDYVAIADGSKRNNMAKVYAGYYKYDDATVDVGHQQRVPMITIVKCGTPAEAGESKPGNRGKRDSQIVLMQFLQKVMFDERMTTMEYEFFNSIWRITGVPADSFEICLMVDADTKIYPDALTRLISCAVKDPEISGLCGETKIANKTDSWVSMIQVFEYYISHHQSKAFESIFGGVTCLPGCFCMYRIKAPKGPNGYWVPVLANPDIVEHYSENIVDTLHKKNLLLLGEDRYLSTLMLRTFPHRKMMFVPQAVCKTVVPDTFMVLLSQRRRWINSTIHNLMELLFVHDLCGTFCFSMQFVIFMELVGTVALPAAISFTLYLIIQAIMGSPALIPLILLALVLGLPAVLIVMTSRKIVYVGWMLVYLFSIPIWNFVLPSYAYWHFDDFSWGDTRKVEGGEKDKGHADGEGTFDSSKISMKKWSEYEKDRRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KR06</accession>
    <name>A0A167KR06_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_150266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286716.1">
        <property type="nucleotide sequence ID" value="XM_018432439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KR06"/>
    <dbReference type="FunCoup" id="A0A167KR06">
        <property type="interactions" value="1069"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167KR06"/>
    <dbReference type="GeneID" id="28993345"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150266"/>
    <dbReference type="InParanoid" id="A0A167KR06"/>
    <dbReference type="OrthoDB" id="6508832at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23807">
        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000026">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="5"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD68676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="136" mass="15441" checksum="CF46CD564011B32F" modified="2016-07-06" version="1">MGQVPRNFRLLEELEKGEKGIGDGNCSYGLADDDLLMHKWHATILGPPVSVHENRIYSLKIYCGEDYPDQPPSVQFVSRINLPCVNPHNGVVDFNRLPCLAQWKRSYTIETILLELRREMCTSGRKLPQPPEGSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KSL6</accession>
    <name>A0A167KSL6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_74217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286819.1">
        <property type="nucleotide sequence ID" value="XM_018443005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KSL6"/>
    <dbReference type="GeneID" id="29003911"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_74217"/>
    <dbReference type="InParanoid" id="A0A167KSL6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="128" mass="14546" checksum="7F102EC05C215C37" modified="2016-07-06" version="1" fragment="single">TVTGIIPRPVSKINDITLKHIYKMITDNLGIELTKKTKRIVNTCTKVICDQLAALPSVQDLGTNPGWSLLPQEDKNRLCINHSIILRDNGIDFTRCHRNWASIARVSQLWRGRKKREYSGILASTIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KTU4</accession>
    <name>A0A167KTU4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytosol aminopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_116888</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286908.1">
        <property type="nucleotide sequence ID" value="XM_018428550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KTU4"/>
    <dbReference type="STRING" id="763407.A0A167KTU4"/>
    <dbReference type="GeneID" id="28989456"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_116888"/>
    <dbReference type="InParanoid" id="A0A167KTU4"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF48">
        <property type="entry name" value="DIPEPTIDASE B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="5">
        <location>
            <begin position="320"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD68868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="502" mass="54930" checksum="0DC4265AAEA91348" modified="2016-07-06" version="1">MADLDATFGESLQVIIPQDAQPSKRVLLAPVGSVSNDFDDVRRFKDAAYEAGLKAIKVGITSPLIYFADSPAQNQADWTFSAEQDYAYFIEVTLLGFLEASFEPIDVREHLERTNKPIPGFKELGLVSSLVRESADEVIQKVLAIEQGKRVTKDIGSPDPERMSPINIVKYLEEQFKDSPHIKMTVIEDIEVIKQEYPLAHAVTRASLAVPRHHPRFVHFEYKSPDQSQVKENLYFVGKGVTYDTGGADIKCSGHMRDMSRDKCGAAAVAGFMKTVELLQPKEVNVTAGLALVRNSIGSDAYVSDEIIYSRNGSRVLIGNTDAEGRMVMTDLLCEFKERAVAHKQAGDASSNAPSLMFTVATLTGHAIRAYDGYAIALDNGFARRNKVSQRLFDAGHILGDPFEISTLRREDLDVVQPGRSSEDVVQANDKPSTMTNRGHQYPAGFMLIASGLNKHGLAHDQPIAYTHLDIAGSSETISAVGWSLPRTTGSPIAALTGAFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KXJ8</accession>
    <name>A0A167KXJ8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_159846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287157.1">
        <property type="nucleotide sequence ID" value="XM_018434070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KXJ8"/>
    <dbReference type="GeneID" id="28994976"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159846"/>
    <dbReference type="InParanoid" id="A0A167KXJ8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="118" mass="12598" checksum="BEC10C1C0E4FA435" modified="2016-07-06" version="1">MSAKTTKAAWSTKTMTCAMSAETTKAAWSTKTMMCAMSAETTKAAWSTKTMMCAMSAETTKAAWSTKTMMCAMSAKSTVCARSTKSTKHAMFTESAMHTMLMESAMLSVFAVSAMSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L069</accession>
    <name>A0A167L069_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_116483</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287327.1">
        <property type="nucleotide sequence ID" value="XM_018428521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L069"/>
    <dbReference type="STRING" id="763407.A0A167L069"/>
    <dbReference type="GeneID" id="28989427"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_116483"/>
    <dbReference type="InParanoid" id="A0A167L069"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019413">
        <property type="term" value="P:acetate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000001">
        <property type="entry name" value="Aldehyde dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="10"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD69287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="474" mass="51733" checksum="5190C9DDBE68388F" modified="2016-07-06" version="1" fragment="single">LFINNEFVPGHGPLIETINPVNEQVICSVHSADESDVNAAVKAANDCFKNEWRKIAPAERGRLMNKLADLMQRDIDELATLDALDNGKAFTIARDVDVTDSIGCFRYFAGWADKIHGKTIDTTFDKLCYTRHEPLGVVGAVIPWNYPLMMAAWKFAPALAAGNCVVMKTSEVTPLSLYKFAALCKEAGFPAGTVNVITGYGHTTGNYLSNHPGVSKMAFTGSTVTGRKVMEASSKSNLKKLQLELGGKSAQIVCADADLESAAVWAAGGIFNNHGQSCNAGSRILVHESVHDKFVQLFVKEAENIKLGDPFDVETFQGPQISKGQFEKILSYIELGKKEGAKVAYGGKRWGTTGYYIEPTVFINCNNNMRVMREEIFGPVVAIGTFKTIEEAIDIANDSDYGLAGGVYTSNIDTAIKVTNEVKTGTMWVNCFDVFDQSTPFGGYKQSGFGKELGKYALQEYTQVKVVKILRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L7H8</accession>
    <name>A0A167L7H8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_148955</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287805.1">
        <property type="nucleotide sequence ID" value="XM_018432188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L7H8"/>
    <dbReference type="STRING" id="763407.A0A167L7H8"/>
    <dbReference type="GeneID" id="28993094"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148955"/>
    <dbReference type="InParanoid" id="A0A167L7H8"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="320"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="36"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="230"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD69765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="497" mass="56305" checksum="AA716D389D372C9C" modified="2016-07-06" version="1">MARTDGREEVQLSASALASLRLLVAGLIRDFSSAMDHEENNPLHPGSAPSEESSSIISHTHLVNSSHNTHPRPIKMESTRERSSIGRKTINTAKPATITNDRLSSEQLISLSRRIDPSELLPPNCPPTKPDLPPFLYQTCSDLWSRQPLPTHPNIHLLADLFKIRFTQAKCRLSNLLKDIPDHPLSHSLQTPSMHCIQPLFKHHMPGTLKRTVGNGKNLFHLGGRKNILPSPSLPTIRRRNTKGHKKKAPVLQAKTKRTPGTRRQPQAQLIPPITLEDGSVVFVCEPCNKRYKNRGGLIYHLDRCQYQLDKKEEDPVIMHCVCDKPSEDSRERIQCDDCREWLHLDCITKPTTSEFHCPRCVTSYELPQPVDGLIWNPDLSDPHGQVIAAWRDPHHTLTTEAANEAWNRLSEDTYRTNERHTFSHLSAPDNNSLTRQFSFVDTLSGTGLDDVDYDDTDYMSVQQLNNQLPSSALSCEDDNLWFEFTSFDDDHLSPIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LAR2</accession>
    <name>A0A167LAR2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS8m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_116048</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD70005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288045.1">
        <property type="nucleotide sequence ID" value="XM_018428496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LAR2"/>
    <dbReference type="FunCoup" id="A0A167LAR2">
        <property type="interactions" value="198"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167LAR2"/>
    <dbReference type="GeneID" id="28989402"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_116048"/>
    <dbReference type="InParanoid" id="A0A167LAR2"/>
    <dbReference type="OrthoDB" id="409928at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000006">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000005">
        <property type="entry name" value="Mitochondrial 40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD70005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="153" mass="17111" checksum="85AB9BE90DCA000E" modified="2016-07-06" version="1">MPRVHDLCARIQNGFRARLQTMAIPETKMNLAIANILYKEGFISSVSRGNHISPDTEYTATTPDNVATRRLWLNLKYKENKPALEKLTVISKPAKKVNFSVNELKNLANGRRAQFIKPLQPGEIAILSTNRGVLELQEALKKNVGGEVLCRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LCE9</accession>
    <name>A0A167LCE9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_95300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288167.1">
        <property type="nucleotide sequence ID" value="XM_018443894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LCE9"/>
    <dbReference type="STRING" id="763407.A0A167LCE9"/>
    <dbReference type="GeneID" id="29004799"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_95300"/>
    <dbReference type="InParanoid" id="A0A167LCE9"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001732">
        <property type="entry name" value="Zgc:162936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000139">
        <property type="entry name" value="zinc finger protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD70127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="56" mass="6589" checksum="F5C7A587A7502CDE" modified="2016-07-06" version="1" fragment="single">MENNARPYQCHDCHRAFARKHDLQRHSRVHTGLKPYSCAGCKKAFARTDALKRHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LCT1</accession>
    <name>A0A167LCT1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_115569</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288207.1">
        <property type="nucleotide sequence ID" value="XM_018428469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LCT1"/>
    <dbReference type="STRING" id="763407.A0A167LCT1"/>
    <dbReference type="GeneID" id="28989375"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_115569"/>
    <dbReference type="InParanoid" id="A0A167LCT1"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="31"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="5">
        <location>
            <begin position="444"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD70167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="549" mass="60753" checksum="43846D2982BF7C11" modified="2016-07-06" version="1">MVVYTSSHTSVTLPEIDIYSYLFLPNEYNTTRPLDRAILIDAESQRSLSFTQVRDISGRLATGWNKSAGLSKGDVVAVFAPNQYDHALLYFSLLAAKCTISPGNPAYTKAEFYHQIHTSGAKALVTVPSLLPVLTKVCEEVGIPKERIFLFGDQAIGSIKPFYSLLENNSSIELPLKNVDSVNDVAFICFSSGTTGIAKGVMLTHRNFIAQMIQVTKFENGDTNQINDRILAFLPFFHIFGLTTLVIRAFYSLTPVVVMGKYDVEVFCRLVQKHKITIANIVPPVAVHLAKHPAVKNYDLSSLRIIGCGAAPLSREHIDALHKRIPVHVRQGYGMTETTAGCIYQIIGSTGVLLSNMEAKLIDEDCNGINKLGPDEAGELVIRGPQIMKGYLNNTIANSETFLEDGWMRTGDIAKYDQKTGEFYIIDRLKELIKYKGHQVAPAELEAVLMSHASIADCCVVGLYDSTQATEIPRAYVVLQGATEMSETLKGELHAFVNSSVAGHKKLRGGIYRVDKIPKSVSGKILRKEVREWIRLEQEQEYSSTKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LXJ2</accession>
    <name>A0A167LXJ2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enkurin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_159392</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289336.1">
        <property type="nucleotide sequence ID" value="XM_018433979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LXJ2"/>
    <dbReference type="GeneID" id="28994885"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159392"/>
    <dbReference type="InParanoid" id="A0A167LXJ2"/>
    <dbReference type="OrthoDB" id="5600564at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027012">
        <property type="entry name" value="Enkurin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13864">
        <property type="entry name" value="Enkurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enkurin" evidence="3">
        <location>
            <begin position="140"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD71296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="218" mass="24944" checksum="DE61331B5A22B1D7" modified="2016-07-06" version="1">MEKQEWIKRFEAEKAQKERLQDDISSVTDSLTVATEQVRQLLIENEALKKQVEQVYGDPFKTSVVGPASSSLSAIKSQLRSSQVQARTLKATLEQFLRLGDGSEDQYIPQDTPKVDPSPPRHENSLDNLEQVPEKVSSEREDTEPAENDLDILLRDLVLEKELLQAEYSKMPVTGANTLTRRRREELESRLDEVDSHMSKIKLRMRNRNSAQRENLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LY62</accession>
    <name>A0A167LY62_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase family 4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_147831</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289376.1">
        <property type="nucleotide sequence ID" value="XM_018431961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LY62"/>
    <dbReference type="STRING" id="763407.A0A167LY62"/>
    <dbReference type="GeneID" id="28992867"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_147831"/>
    <dbReference type="InParanoid" id="A0A167LY62"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03814">
        <property type="entry name" value="GT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050194">
        <property type="entry name" value="Glycosyltransferase_grp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947:SF3">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="4">
        <location>
            <begin position="14"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="3">
        <location>
            <begin position="199"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="398"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="410"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="423"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD71336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="438" mass="49196" checksum="55A7D1158935D716" modified="2016-07-06" version="1">MHIAIVTENFLPKVDGVTRTLARLLEHLQAGGHRVAVFGPESGMETYAGAELYGTAGIPFLPYPELKLNLWRPEFTRKLVEFEPHVIHLVDPVWLGAAALAICHTKLQDIPVVSSYHTNLATYCGHFGLGIFTPLMWRWNLFCHSRCRYTVCPSPSTRDMLEYHEFQNVRLWPRGVDTTLFSPRHRSCSLRAEWTGQPDTPKTILLYVGRLSYEKNIGLVVDAYKQLDHARCHLVLVGHGPAHNDIKAECERLEIPVTFTGYLQGTELATAFSSADLFVFPSTTETFGQVVLEAMSSGLPVVGLVAEGVRDLVDHRKTGLLLDTTGLTVKEQAKHYKANIITLINDIPLRTVMSNNAIKSASRYSWWEAMECMVQVYRDATEEARLKHTMLDIDNQQINKHSVDERGDSGVEEGFSEEELDDLDRAEAGKSKPIEPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M0H7</accession>
    <name>A0A167M0H7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_147221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289499.1">
        <property type="nucleotide sequence ID" value="XM_018431821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M0H7"/>
    <dbReference type="GeneID" id="28992727"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_147221"/>
    <dbReference type="InParanoid" id="A0A167M0H7"/>
    <dbReference type="OrthoDB" id="2283774at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="590" mass="67967" checksum="9BF8F443542395C1" modified="2016-07-06" version="1">MLASELPYEITFLIANFLQPRDKVQCCLVCKSWLLASQESLFETISVKSYCNVNELVYATNPENNLLRKYCHKTRMLNIGRNICLRDRQLLALQKNLPCVQVFKWNNAIVERYQLINCCGWNLWEKSLTNLKITVLRHDYASLSNIFVSIRSNLSRLRRLHITDQYNERALQCTFNDFELLNDQLPELIYMSLSVHLYEMKPAELLKIKYVKPAPRLKVLGCCVEEATIEWLYYLAVKYPNISTLKTFDFSRFTIDEQTSLAGNIFKQLSFPFQRLENIDVCVNMASEQVYLDFVNQLRLFNTSLKAICLSVDGISRDSMSSNNIIKSTNVFANTLQTIEIKSCPGIVQCLDLIPELVYYPHLVDLNICIKDAIVNLDVLLEKYPLLKTFSISDGVLNSSPNLPIPPTENALCDLSLSNMSISASTLKSISIFCKKLTNMELKCVDIEGSQQGATLYYCIDMSSTHFTTLFIESIQFTNVVNQDTINMFAFSLSNVSAENTWVYSWYMQANVFMAQQSKARKLNKEESKEAGEYFHNFPRNIQPKYTKDQIHDTIRFSSKDNWRDVLSNGYAIFKYGSVKNLLLETKHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M2S0</accession>
    <name>A0A167M2S0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_114373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289634.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M2S0"/>
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    <dbReference type="GeneID" id="28989299"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_114373"/>
    <dbReference type="InParanoid" id="A0A167M2S0"/>
    <dbReference type="OrthoDB" id="10044727at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23859" checksum="5D811BFDC3DCB9EA" modified="2016-07-06" version="1">MISEFQCPCHGTMRGYVGDQYKTSRVVFYPGAQYESYWKSSHMCAQLTDIIPLFNAIHPNAVAVFLFDQSSNHKAYPEDALLAQNMNLCAIEVKDSDSGQGKFRDSSFYVRKQYDYAEQQKNKKYKKYFIGLRGILQQRSMYRNEAERYSLKRSCNNVATADSRCCAIHIMERQPDFANQKSALEEIVEGSGHKFELYPKYHCECN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M6Z9</accession>
    <name>A0A167M6Z9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_146970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD71989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290029.1">
        <property type="nucleotide sequence ID" value="XM_018431771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M6Z9"/>
    <dbReference type="STRING" id="763407.A0A167M6Z9"/>
    <dbReference type="GeneID" id="28992677"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146970"/>
    <dbReference type="InParanoid" id="A0A167M6Z9"/>
    <dbReference type="OrthoDB" id="5597136at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="103" mass="11506" checksum="19E422BEA254AB05" modified="2016-07-06" version="1">MVQHQEESSDSESFYLDDWETQFLETDAANLDSDSELDGYDSDDTVYNYHYNYKDFASSQPLRAPITINGQLIPAIFDLGASVSIISKALALCLGLVPVVNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MEA8</accession>
    <name>A0A167MEA8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_8181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290644.1">
        <property type="nucleotide sequence ID" value="XM_018443605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MEA8"/>
    <dbReference type="STRING" id="763407.A0A167MEA8"/>
    <dbReference type="GeneID" id="29004510"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_8181"/>
    <dbReference type="InParanoid" id="A0A167MEA8"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF30">
        <property type="entry name" value="PHOSPHORYLASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="145" mass="16882" checksum="FBA14CEDCE436FDF" modified="2016-07-06" version="1" fragment="single">DPTLFYKGLDVEPTWFSAQGGVYKCRERKKSAGRVAIKKYLVEENQHEDMFVMPKELVENEIYTMTKCVHPHILKLYAVYLHQEFVYLVMPLCTGGSLQQYVFDHQLTIGQLVYIISSIASGLAEIHRHNYIHRDIKCDNIFLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MH13</accession>
    <name>A0A167MH13_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_65262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290856.1">
        <property type="nucleotide sequence ID" value="XM_018441426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MH13"/>
    <dbReference type="GeneID" id="29002332"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65262"/>
    <dbReference type="InParanoid" id="A0A167MH13"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="202" mass="22384" checksum="07FC57515E6607EA" modified="2016-07-06" version="1">MSCNMSVILKGKMVMLPESGFQTKERSSFQTSATHTLIFRVIIQHLYATPELSSNVSTTKCILMIKESALDGAVYFCNLSLITNKKCIQLNNKRNITSLLVFSNFSVMEATGVSALQLLEPKVGVRLLHGFVSPINCFWSIMLSCHAPESVLVAVTVYMICRAYWNFAFEEFPLLNSVVAKNTSSVVSRSSATRTSDNNSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NC04</accession>
    <name>A0A167NC04_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_101274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293669.1">
        <property type="nucleotide sequence ID" value="XM_018427634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NC04"/>
    <dbReference type="STRING" id="763407.A0A167NC04"/>
    <dbReference type="GeneID" id="28988540"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_101274"/>
    <dbReference type="InParanoid" id="A0A167NC04"/>
    <dbReference type="OrthoDB" id="10044727at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="27961" checksum="5CAF84A65E4B1507" modified="2016-07-06" version="1" fragment="single">QCPCHGTMRGYVGNQYKTSRVVFYPGAQYEGYWKSSHMCAQLTDTIPLFNAIHPNAVAVFLFDQSSNHKAYPEDALLAQNMNLCAIEVKDSDSGQGKFRDSSFYVRKQYDYAEQQKVFFQKKSNEEKLKEYEQRSMYRNEAERYSLKRSCNNVATADSRCCAIHIMEGQPDFANQKSALEEIVEGSRHKFELYPKYHCECNWIERYWGAAKKEARRECDYSFQSLNRKINSFLDSVCPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NF00</accession>
    <name>A0A167NF00_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_180392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293788.1">
        <property type="nucleotide sequence ID" value="XM_018438307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NF00"/>
    <dbReference type="GeneID" id="28999213"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_180392"/>
    <dbReference type="InParanoid" id="A0A167NF00"/>
    <dbReference type="OrthoDB" id="2243446at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="288" mass="32390" checksum="06B7BBA2748DB7E0" modified="2016-07-06" version="1">MSSEFQTDRDFVAAGSTYFGFGITTAFLSALVIIGASVQLRNHGHRHLYIPTIAAGACYFINGCLAAAVGRIITTTVNDEIPWTFQDLTTRELLRDFFSDAFAPISWLIVFETYRLIVKPFSTDSPVLANDNNNSAKKRPLWSVINTYFGYLWIVMLLICEIVALVSLSQLPAGSPETRVYQQLVTSAKLFLFTSFGLWVLPVLSIIQAKISSRHIRPFISSFLSYQFFLFLVIIGRTIKMLSLATFQQTYRTVEFAFVDMFGLLGLSFVIMFGHTWTKPPSPNVKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NLS3</accession>
    <name>A0A167NLS3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_76030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294264.1">
        <property type="nucleotide sequence ID" value="XM_018443115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NLS3"/>
    <dbReference type="STRING" id="763407.A0A167NLS3"/>
    <dbReference type="GeneID" id="29004021"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_76030"/>
    <dbReference type="InParanoid" id="A0A167NLS3"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF19">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="169"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD76224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="522" mass="58608" checksum="5CBF225933C54D15" modified="2016-07-06" version="1">MSYLVAKRLVSRQRIDLSQTHRYLNTQATRPTKPSIKWSNMIPRPSVWRATVYEHYTKGPPAKSWPLSYHLLIATIRDFLDRGCLSTVEQAQYLTNSIKNPIPSGFKETPAIIPSSYRTQAGDNLSQLLSLRDQRKIGWDWQSDRQNASSLEGEWMEKDGQDDQNSPVVYYLHGGAYYLCSFGMYRRFISDILKGSNARSFAIDYRLAPQHPFPTAVEDALAGYLYLINPPPDAGFSPVDPKKIVIAGDSAGGGLTLALLMAIRDARLPPPAGAMPLSPWTDLTHSLPSILSNAATDYLPKLGFKHAESPALDYSVLPKLKHNEDDHEEISIGPFGKKIDLSEVTKEDMDRIQFYTNNASIKLSLASPAFDKKDLHGLPKLLIQVGLAERLRDESIYVALKASGKYPGASDYKSKLPSTPVTLEIYEDQPHVFQILIPTKASKCANSRLAKFVIEATQPDQKEQESKDESLVAIQITPEGEHKDVTQDLLERMTLGKWDEWEARLARPSLLERLKEMREKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P6Q4</accession>
    <name>A0A167P6Q4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_164274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295396.1">
        <property type="nucleotide sequence ID" value="XM_018434980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P6Q4"/>
    <dbReference type="GeneID" id="28995886"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164274"/>
    <dbReference type="InParanoid" id="A0A167P6Q4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD77356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="162" mass="18932" checksum="4FE83CC01A2045ED" modified="2016-07-06" version="1">MPSLFTLTRLSYSKLDRPHSSLLTFVLVRNTLTAVTLIPPHQWHLEIKDSYLQKSKSEPESESEPESEPEEYDDHDHDHDHEESEESEEDDMPPSPKDNDQFNQIPFYKRTGPAFFIPFDDEEDEDEDEEDWRLDSSCWSTNYYPTPESSPSSVLSWSSNCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PAB2</accession>
    <name>A0A167PAB2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TRUD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_164467</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295601.1">
        <property type="nucleotide sequence ID" value="XM_018435011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PAB2"/>
    <dbReference type="FunCoup" id="A0A167PAB2">
        <property type="interactions" value="808"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167PAB2"/>
    <dbReference type="GeneID" id="28995917"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164467"/>
    <dbReference type="InParanoid" id="A0A167PAB2"/>
    <dbReference type="OrthoDB" id="447290at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02576">
        <property type="entry name" value="PseudoU_synth_ScPUS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRUD" evidence="4">
        <location>
            <begin position="365"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="503"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD77561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="677" mass="76264" checksum="DEC7EC04E57CB4EE" modified="2016-07-06" version="1">MGQVFSTTKPESTPLTTSGKRKASFDSSQTLKKACKDATFESATPEVIITEQDVGILAFVNPNLKGFSSIMKYRAEDFLVNEVNLDGKIIRLTSLDPPVIPERQKFFLSDAEFDAKIAGIISPEFAKELRNVLNNPNDITVSARAKKADYSNFNHKNVEKASRIDFYNAIECNLDAPLMTECLEGVLIARWKNPDDTAHTKVGVVKEKPRKINFDITGGEYVSFYVQKSGVDTMGAVNIMANIGGPRFLPKQFSYAGTKDARAVTVQEMTLFKCDPRYLYDVRNELAERQIYIGNFSFANKGLTLGDLSGNHFTIVLSAAQCVLKGTMSLILKKKDNVWLYILRDVNGASEEDIHESLQSLESRGFINYFGMQRFGTSSICTHEIGRALISLKFAEAADLVLMPRDGDRADFAAARNHWAETKDIKSTLDKLPRQAHTERKLLSSYLRFDNQHEKAFNSLPQHMLSLYYHAYQSYIWNCAVSERAKIYGCDKPVVGDLVLVDGPEKSNNNSNNNNKKYGNAGRRDHSSRKVPKVLTEEDLDNYTIWDVVYPMPGSRSKYPANAIGDFYKQLLEKDNINIKNAQQHFKKLMGDYRPMMVKPKNVGWKFIRYDNPETKLFNTDYDRITSVPEPVSVPNGKYLGLAVELTLGTSQYATMALREVMRSDTSAKAQARNVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PH33</accession>
    <name>A0A167PH33_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GIY-YIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_68596</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a heterodimer with SLX4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the SLX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295939.1">
        <property type="nucleotide sequence ID" value="XM_018441977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PH33"/>
    <dbReference type="FunCoup" id="A0A167PH33">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167PH33"/>
    <dbReference type="GeneID" id="29002883"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_68596"/>
    <dbReference type="InParanoid" id="A0A167PH33"/>
    <dbReference type="OrthoDB" id="24645at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10455">
        <property type="entry name" value="GIY-YIG_SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03100">
        <property type="entry name" value="Endonuc_su_Slx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027520">
        <property type="entry name" value="Slx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048749">
        <property type="entry name" value="SLX1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050381">
        <property type="entry name" value="SLX1_endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208:SF10">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21202">
        <property type="entry name" value="SLX1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="9">
        <location>
            <begin position="6"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD77899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="277" mass="31639" checksum="ADA78B3C7ED819FE" modified="2016-07-06" version="1">MEPSCVFYSCYLIRSLNPDYPNRVYVGSTPDPIKRLRQHNGEITQGAKKTTPYRPWEMVMLVYGFPSNLCALAFENAWQHPLESRHLKRSKCYANKDNAFGMSSKQHANLLLSKMRAVHDVLSTKPFSRWPLNIHFITPAFKCLFEAEGQGMAGILLPHHIKTTLGPLTNLPLKKFQLDKKDDPVYHNFCSMADKVPCYMCKLDVEKKNTQAFVGCLDCKMVTHLRCLASHLLLMDSDSDNELVPVKGKCPKCDTDMLWGDLIQALKKRSTWALEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PJ86</accession>
    <name>A0A167PJ86_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CCHC-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_141919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD78056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296096.1">
        <property type="nucleotide sequence ID" value="XM_018430697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PJ86"/>
    <dbReference type="GeneID" id="28991603"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141919"/>
    <dbReference type="InParanoid" id="A0A167PJ86"/>
    <dbReference type="OrthoDB" id="2290219at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD78056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="353" mass="40274" checksum="6CE2088CEEBDCEBC" modified="2016-07-06" version="1">MNNEEALNKFVCGLHPSIRGNVLAARPVDVDDACNIALAYASGLQLGYQNNYTSVPPLQQYQQQYQPQYQQQQYQYSGPEPMDLDAINNRRSNYQSCPPPRRTNATCHWCGDSGHFKRYCRDRLAAIKKLDEESLKKQGFCEAQPNEPTEHLSNKETFDQYKIVTNEEKKAISKENCDPCLTTNQHFLEDLHSAVDTDLSLYAATLHGQQILILIDSGASANYVLPWIKHLATKVSNIPGQSVETAGGHSIKINQKATLTLSLNGYTDSTAKPVPDWHRDNWSLYRDGQEFVLRPHGNRPMKPQLNYLISAKQVQKLSRREEAECFLLHIKTEKEVTNDEQWMKLVKEFDNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PSX1</accession>
    <name>A0A167PSX1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_185210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296519.1">
        <property type="nucleotide sequence ID" value="XM_018439047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PSX1"/>
    <dbReference type="STRING" id="763407.A0A167PSX1"/>
    <dbReference type="GeneID" id="28999953"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_185210"/>
    <dbReference type="InParanoid" id="A0A167PSX1"/>
    <dbReference type="OrthoDB" id="4088568at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="619" mass="69509" checksum="CF3DE2948F68AF93" modified="2016-07-06" version="1">MFSHNNHDYGQMICNILILQIAPVINSITPEMQQSNMNHLLDLVKELASANSKFKTDLMDCRGQLNEAHIEAAAYNNKIYGIDRDEEGEEQRENCGNGVPRFMEVTASSIYTDNLALLSRSAPSLHALGRTNGGRMTKPLREVRLAEQPPITDIQNQPKKDLKQHPFHAMSAKERCPPSKKGKDVARTKTGPIPKPSASSPAGSIIHHHYHYHERRNKKEILGKEKAVSLRAANDTDNSQSDTPSLEENPKRKSIQDMDQLTTTELLAPRRSLEDSEPKSPYSQLQEHVSQTLQRLIATDIRALNRNLRRTFDIFELSSMSNSIIENILTDVGALSSRFIWVQDEISYNTHNESLNAFFPILQLFQDLLQEMGQLRSTMNELQVEYVKKVEQYGQKVEEEIVQKREKLKKTASTPTTNMAQSPSGPLAWFAQVFQKATHHPTDRMVSKSISRSISCESIPPQYPHEQSTFMGKPYGLSATYASLQDDHNDGYHSRPSSTMEKERQGMDIRRVKSSTSRYGPASSYPRSSPLTAEKLSHRVPYPVIRASQSTGTDRKAKVRQVPSLGRESGQRQKSPLRLTPSGASAINYDGTVPQTSASERASDWKVGGHFSTSWLGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q8B5</accession>
    <name>A0A167Q8B5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NOL9 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_157196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297298.1">
        <property type="nucleotide sequence ID" value="XM_018433581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q8B5"/>
    <dbReference type="STRING" id="763407.A0A167Q8B5"/>
    <dbReference type="GeneID" id="28994487"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157196"/>
    <dbReference type="InParanoid" id="A0A167Q8B5"/>
    <dbReference type="OrthoDB" id="2405412at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057570">
        <property type="entry name" value="NOL9_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25467">
        <property type="entry name" value="NOL9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NOL9 C-terminal" evidence="1">
        <location>
            <begin position="108"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="180" mass="19931" checksum="49AFEBC425FE6853" modified="2016-07-06" version="1" fragment="single">MISYFHQTPSSTLSPGQPGWDFETRLVERVPWTLDWRHLKGVWILFEEVTTRQLLYSLNGSVVGLIGDVVDYKPVESQRSVDLATQEQSLVSPAYFDSLNYPPPPPSKTTCHGLGIIRAIDPSKHALLLLTPLPLDTLKLVSGIVKGDLELPIQCMLDEKMGSGPGICGVPWNMTPYVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QLI2</accession>
    <name>A0A167QLI2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_106496</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297921.1">
        <property type="nucleotide sequence ID" value="XM_018427950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QLI2"/>
    <dbReference type="FunCoup" id="A0A167QLI2">
        <property type="interactions" value="608"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QLI2"/>
    <dbReference type="GeneID" id="28988856"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_106496"/>
    <dbReference type="InParanoid" id="A0A167QLI2"/>
    <dbReference type="OrthoDB" id="2877at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000017">
        <property type="entry name" value="probable 18S rRNA (Guanine-N(7))-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="9">
        <location>
            <begin position="53"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal" evidence="10">
        <location>
            <begin position="199"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD79881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="32208" checksum="81733147F52AC588" modified="2016-07-06" version="1">MSRPEHIAPPEIFYGEVEARKYTDNSRIASIQAEMAYRALELLNLSEGPKFLLDIGCGSGLSGEILEEEGHVWVGMDISPHMIDVAREREVEGDLFVQDAGQGVGFRPGTFDGCISVSVLQWLCNADKTINRPKARLQRFFSTLYASLKKSARAVFQFYPENDDQIKLIIDVATRCGFEGGLLVDYPNSKKAKKYYLCLFAGTQTGRRNELPKALGEDGEMHPDEVKSISNENRRLVTRKRKTNRTSVKDKKWVQHKKEVARDRGDKVVANDSKYTARKRKVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QQ21</accession>
    <name>A0A167QQ21_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_105693</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298087.1">
        <property type="nucleotide sequence ID" value="XM_018427914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QQ21"/>
    <dbReference type="FunCoup" id="A0A167QQ21">
        <property type="interactions" value="894"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QQ21"/>
    <dbReference type="GeneID" id="28988820"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_105693"/>
    <dbReference type="InParanoid" id="A0A167QQ21"/>
    <dbReference type="OrthoDB" id="10264376at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051858">
        <property type="entry name" value="WD_repeat_GAD-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017">
        <property type="entry name" value="GASTRULATION DEFECTIVE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="133"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="183"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="230"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="393"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD80047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="497" mass="55779" checksum="C58F0A9764988755" modified="2016-07-06" version="1" fragment="single">DNEDDEDDDDDDDNEEVEASSDVLPITHEIRLRDHQRTVSALTLDPSGSRLITGGYDYEVKFWDFSGMDKSFRPFRTLEPCPGHQVHDVLYSLTGDSFLAITGSARAKLYDRNGLELCEYMKGDPYIRDLRHTDGHVGALTGGAWHPTDRKTFITSSQDGTIRLWDVDNKRRQKAVIPYKSRERGGRSSATAVSYSHDGKTIAGAFQDGTLNLWDTSSSFLRPVMAVPDAHQKQSETSSVVFSRDGHTLVTRGGDDSVKLWDTRNIKKPVRTAYNLEVVNPQANVIFSPDERLILTGTSVPKGEGYGKLVMMDRETLEIRRTMSVNQSSVVKVLWHPRINQVSIVTGSADGTVSVFYSPTHSVRGAKLCVVKEAKKRAVDDYEIDRPIITPHALPMFRDDEPRSSKRKREKLRRDPKVSHRPEMPVNGPGKGGRVGLNEQQAVIAGFSKDTTRDEDPREALLRYADAAEKDPMWVSNVYKSTQPKPVFAEEQEQESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QXE7</accession>
    <name>A0A167QXE7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_161070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298467.1">
        <property type="nucleotide sequence ID" value="XM_018434339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QXE7"/>
    <dbReference type="GeneID" id="28995245"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161070"/>
    <dbReference type="InParanoid" id="A0A167QXE7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="104" mass="12015" checksum="48F3EB3E371875B2" modified="2016-07-06" version="1">MYKGKCANDKYIGSITRYNLDQERKEGKKKLLLLMLSSSLSLSLWWGNRSRVLPHHHIYIHRLILILTLILILIFNININININIGIGIGINVNTMIIMSIRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QZI3</accession>
    <name>A0A167QZI3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_161163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298557.1">
        <property type="nucleotide sequence ID" value="XM_018434352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QZI3"/>
    <dbReference type="GeneID" id="28995258"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161163"/>
    <dbReference type="InParanoid" id="A0A167QZI3"/>
    <dbReference type="OrthoDB" id="5982876at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="172" mass="19630" checksum="CF37D7ED3452C4E4" modified="2016-07-06" version="1">MHHEHAFRSFSLAQIPLVVYTSLSAVKYIIKRVGETGSLQQRRGSERARKLDDGIEIHLMNVVPKDNFALYSRLKTSLKKIEVFVRKIKAIISYLKRLGFGLCIAAHKLVKGNDGEAGAIKSCEKVQRKYHYENQVKDVLNTNAKEEEVLVCKQFLLGLEIYDLTKNIKNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R2X0</accession>
    <name>A0A167R2X0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_129350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298764.1">
        <property type="nucleotide sequence ID" value="XM_018429284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R2X0"/>
    <dbReference type="FunCoup" id="A0A167R2X0">
        <property type="interactions" value="748"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167R2X0"/>
    <dbReference type="GeneID" id="28990190"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_129350"/>
    <dbReference type="InParanoid" id="A0A167R2X0"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD80724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="155" mass="17267" checksum="88C81825B5BC55A5" modified="2016-07-06" version="1">MQIFVKSLEGNTLVIGTTASSSVADVKAMIQAREGIPADAQLLSFAGKPLVNENALSLYGVQDDSTLHLNCELLGGAKKRKKKTYTTPKKIKHKRKKVKMAILKFYKVDQSGKITRLRRECPSATCGAGVFMAWHSDRQYCGKCHLTYVFQKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R3R6</accession>
    <name>A0A167R3R6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="12">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_29356</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="12"/>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298818.1">
        <property type="nucleotide sequence ID" value="XM_018439946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R3R6"/>
    <dbReference type="FunCoup" id="A0A167R3R6">
        <property type="interactions" value="727"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167R3R6"/>
    <dbReference type="GeneID" id="29000852"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_29356"/>
    <dbReference type="InParanoid" id="A0A167R3R6"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000004">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000040">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
        <property type="entry name" value="PRK08560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="352"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD80778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="411" mass="45102" checksum="18AF23CAEE153106" modified="2016-07-06" version="1">MASLTPEEKYTLITRNLQEVLGGDEIKKILAERDLKMYWGTAPTGKPHVGYFVAMSKIADFLAAGVEVKILLADLHAFLDNMKAPLELVGHRVKYYEALIKAVLTSLGVPIEKLTFIVGSSFELSREYSMDNLRLAACVTEHDAKKAGAEVVKQVDSALLSGLLYPGMQALDEEYLGVDCQFGGVDQRKIFVYAEKYLPQLGYKKRSHLMNAMVPGLAGSKMSSSDPDSKIDFLDSAKDVQKKIKKAFCEEGNIAENGILSFVKSVYFPLKTLHGNKPVFTAIRPEQYGGNMVFNNYESLEKAFADKTVHPGDLKAGVIAAINELLEPIRKAFEDPALIELTKLAYPPIETQLKQKPKKDKKAEKKEKKLKEAAAAAAAGEATPSASATFAAVPVVVAKQEEIKNEEVKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R867</accession>
    <name>A0A167R867_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_178854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299118.1">
        <property type="nucleotide sequence ID" value="XM_018438050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R867"/>
    <dbReference type="GeneID" id="28998956"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_178854"/>
    <dbReference type="InParanoid" id="A0A167R867"/>
    <dbReference type="OrthoDB" id="10453221at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007891800" evidence="2">
        <location>
            <begin position="24"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD81078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="86" mass="9970" checksum="35921C6FD802DF77" modified="2016-07-06" version="1">MKFYLFLLSVLLLTIFGTQVCIAEDPALLEGQGTIADDIKKFESRPSLIDRLALEREQRQQKAQEQPQKRRRFAKRVPAVQGLKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R8B1</accession>
    <name>A0A167R8B1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_161723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299127.1">
        <property type="nucleotide sequence ID" value="XM_018434451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R8B1"/>
    <dbReference type="STRING" id="763407.A0A167R8B1"/>
    <dbReference type="GeneID" id="28995357"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161723"/>
    <dbReference type="InParanoid" id="A0A167R8B1"/>
    <dbReference type="OrthoDB" id="2379842at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD81087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="297" mass="33809" checksum="A94B934518636C5A" modified="2016-07-06" version="1">MEEVIKLESLFWSCEGSQQVANLLNKIKKVTSEFEGKTGHPSINFQVLEKIKYPGRRKGSARPKYLPKDFGRANWRKISVSSGHAGLKAMVRLRAKMREGKPAATQKQNKNKQEPLDPVDAPQKNGFKRPATTLEDYQYDNRTSVGKRVKFQPGFPVSHEIVDDVKGGFSPTADGWCGFRVLAHLIYKDQNKFSLVKRDMLAALPKYKTLYTNTFGTDTSQLEKIIQHGSQLDYSNTSNTNTNFIPVCSDASCARNKIDDNFDTYWNKFKEFNKHDRRNAMLSLHSDLDQPIDLTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167RE66</accession>
    <name>A0A167RE66_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_184619</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299487.1">
        <property type="nucleotide sequence ID" value="XM_018438961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167RE66"/>
    <dbReference type="FunCoup" id="A0A167RE66">
        <property type="interactions" value="419"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167RE66"/>
    <dbReference type="GeneID" id="28999867"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_184619"/>
    <dbReference type="InParanoid" id="A0A167RE66"/>
    <dbReference type="OrthoDB" id="1588579at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="176"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD81447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="535" mass="60099" checksum="BCB73B8219C84B13" modified="2016-07-06" version="1">MVYLNYIVNYFNCLQVPPHLPPPLFRQMISRMPGVSFISRDSSLLSSGQYSSQEQSPALSRHISLGDLSSLPSSISWASRATHSHSISGRSIPSPGSKRTSSTRTHRINLPKQSEAAQQPPSIRPHFSMFGGHDSNTDDLSTRHVDTYDISPLQTFWQSLPGSKHFALSDNFKFIINICMWYISSSLTNNIGKQILTSFKYPVTLTFIQFALVAMWCFLVANLASTTHIRSPTQEIVRTITPLAVFLIVGHVFSSIAISRVPVSLVHTIKALAPLFTVLFYRFIFQVHYTPNVYISLLPLTFGVILACSFTYSNSVVGLSCALGSCFVFVTQNIFSKKLLFKEAKMGDRNPNKLDKINVLFYSSFISCVLMIPLWLYSDGSSLMAFSVGNEGSLTKTQLVVSLFLNGTMNFGQNWFAFTTLSMTSPVTYSIFSLLKRIFVIVMSIVWFGQQVTITQSLGIMMTFIGLWMYQKAKRDVDRGETKIREKSLDGLPTEEIPLEDLPRHRMEGFTLPVNQAKKWASTLIPQTTRDEKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167REL6</accession>
    <name>A0A167REL6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_162078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299508.1">
        <property type="nucleotide sequence ID" value="XM_018434559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167REL6"/>
    <dbReference type="STRING" id="763407.A0A167REL6"/>
    <dbReference type="GeneID" id="28995465"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162078"/>
    <dbReference type="InParanoid" id="A0A167REL6"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="170"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD81468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="671" mass="78094" checksum="DAC931BEADF0C151" modified="2016-07-06" version="1">MTQKGFIEKRQCAAVFTVKRLEEVFPNDSTTGSIYFLRGYRCQGVIRQDTTRLLKRVLELEKPEESKKAISIKVTLQKISGSEKKLRLPNAIKANLKLETTINYTKENLNRMWRTKYTELCRNNGQTYPLEYSIGPEIKVPVSFEDLINQPVALLTYPPLSSYLDCPSFSDIRVTVYENEVMVGEQSVFNCHKVILAAASPLFDKFFTEKMDGSEKKGKIIHGVHPEIFKKILVFIYSSDYDVKDVNEASKIIEAAHRFELPDLSCYHCTDTQGYCQKFIRKNVRKLLSSEAWIHLDPESVIRTLNIDHISPPVKENLFYEAVLDWREQALYNIRSNSEDHDDPGSSHTLVDDTKKSLEKGPGYPQTEEDVEEAFEEMISLIRFNQMDTKYLFEKVEGDFEIMKSDKCKKLRLFLLLIISSMLHLPMAVPPETLFVFKTLAAIYPNKIPPPYDEREKYHSRLQLLLSTKQFFPYLRAINTVCCNKNAWLLHLFHDALQHSNVKIKHATIDFDMYTSNVKNLNTWIKHYSESVNILCIYHGNDYSSIPAARKLHLKYMTLNEIKYHCSDFDETGQALVDMHFSPLKVLITYDTSFKYFDSRSSQPPKLIVIEQKGNDNIDQGQAPQSSWYHLCADRTNRKSRMLVWELGRRDIEFSQRHLKNFKRRKGRENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N217</accession>
    <name>A0A162N217_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_176462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441042">
        <property type="protein sequence ID" value="OAD65054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283094.1">
        <property type="nucleotide sequence ID" value="XM_018437784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N217"/>
    <dbReference type="STRING" id="763407.A0A162N217"/>
    <dbReference type="GeneID" id="28998690"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176462"/>
    <dbReference type="InParanoid" id="A0A162N217"/>
    <dbReference type="OrthoDB" id="2283382at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="24"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD65054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="157" mass="17882" checksum="510FF47CBD72EE86" modified="2016-07-06" version="1">MLDSYNAMEMVEKLSDTVFTCRSFTVDLVIYNIELHNGFLQNCTCPDTSKLCKHIFLINRMLDIPYSLCQSLSSSSSAVHVSNTDTKAVVDTSLLSDEIEADIINYYQVYSVELDSKIAAYMEISEDVSKFLNTLKFAYNKLKKYGFPSQSRPPQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N6S8</accession>
    <name>A0A162N6S8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_69958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289748.1">
        <property type="nucleotide sequence ID" value="XM_018442188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N6S8"/>
    <dbReference type="GeneID" id="29003094"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_69958"/>
    <dbReference type="InParanoid" id="A0A162N6S8"/>
    <dbReference type="OrthoDB" id="2243238at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="606" mass="70687" checksum="254D0C072B5B8742" modified="2016-07-06" version="1">MSKRLPYDVLSYIAKYIERDTQLTCAVVCKQWTEPFLDAYWHYPFINSKALKSLCKKSNRNNVHLRNLHRTRGLTTYYLTEKEMKLFPTLQQIYQNINHVEYIEATDYEPILNTTDWSPWKSLRRLKIDYDYTWTELVRDILFTLSPLTSLVHFIFKTTSSHDDDIKGHGAASRLLTTTGVLESVKEIAPAKTIKEVCFDNDSLSTPWMFYFACKYPNLQTIRFKDGYRSPESIEEDYEPKYYKDDLQILSCLDQFFPCLKSAHIFTESWNGWPFSLFTSSLKHFGVKLEFLNYGTNSFGPDWLVHSNRCLQPVADSVQTMKLDIAYADDNKLRTNDFNLYPSLVKLRITLRSRPRINIILDKCPKLRILDLSQGEALSLSNYAKHSQNQSLSIHPLRRLNAQSTSIHPEIFKYLSFRCQQLLDLKLCKINLIEGDWLKTGQLHMDMLFSQLNTFELAQIHFSKQKTFKLFAIAQTENTNTNSTSNTNTNTNPDTDINLPEQSNQPQLTQLKWYHVCLDNSSGKQKAAIWELGSQDIDFAQRYYENFPENQARDQAHDQEQENLPQPSATGLIPRSDWQKDLQYGVIIIRVKSVKYFIFDSILLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N8X7</accession>
    <name>A0A162N8X7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_151882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD66944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284984.1">
        <property type="nucleotide sequence ID" value="XM_018432770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N8X7"/>
    <dbReference type="STRING" id="763407.A0A162N8X7"/>
    <dbReference type="GeneID" id="28993676"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151882"/>
    <dbReference type="InParanoid" id="A0A162N8X7"/>
    <dbReference type="OrthoDB" id="2389915at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="857" mass="95420" checksum="303548202642A99D" modified="2016-07-06" version="1">MSSNSILDSYQCNQCKERHTNLKKAKSCRAQCFKNHHRRHNDIQTSQTTLVPGQVSVVLNTVSNDTIEERADAIKDQIMDTLNSEDNDDPIMNIFSNDDNDESMYDAELGNDMDIIENETSPLVFDFSQPAPTPDKDDAKNLEFLKIIKDFGIFRNAHEMIVKHFNSILETSTCITYRACTSHLSKKLLKRFSGVEETTECSNCGQSRYKTRRGETEGGDLVATATMIQLPLARQLALALANEDTRADIHYRHNHESSSDGSKTDVFDGQVYQQAKHLFSGKDDIAISLSVDGFMPHNVPGSVTILHATILNLNPMVRYERSRILQIAMIPDPGAPANFWSFMEPTMKELLVLESKGMVIKTPNETISAKVHVLMVTGDILALAKLACHSGHMSKDGCRICHVVGQCPKHGQYFRTLPSTNIHTLESFQNFSQASASSRKGLNGQSPLATLKVFSGPLFFALDEMHGLCHGISKQVWGLVSGTYGTDHCFALSSGVWKEIGTAMYKTRNTIPTSFHGDWRDVYKNPGSFKAVDWADFLLFVVPTLVAECIGDATARNALLGLVQACNLLMSWELSAEEQTSIKSKLEIWNMYLESLLTSGKIKINIFTINQHLLQHYPLTIDAYGPPHAYSARSVERAISEYSRAIKNSTAGWPLTDEGERVGAGSDIEFWGPLRNRTIRDSFEGISCLSKLLEDFYESKGKECSMIEAAIQTSHKAFVNGCVIDSALDQNCVREAHNIRLQIQVDENRNINSAYSPVYKDFFGKVVVFFEHKLNNKRWPLALVEIVAVRLVNGIPVINNGQMKPKVVHLADVKELVGLVKSDATINTTTTTTTTTYIVWSELNRGPKLSLGSLADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N9L0</accession>
    <name>A0A162N9L0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_67258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441025">
        <property type="protein sequence ID" value="OAD67124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285164.1">
        <property type="nucleotide sequence ID" value="XM_018441764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N9L0"/>
    <dbReference type="GeneID" id="29002670"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_67258"/>
    <dbReference type="InParanoid" id="A0A162N9L0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="119" mass="14157" checksum="76AF91BCC2FC2955" modified="2016-07-06" version="1">MCFNSHWHFQLTSLLISSAYLDDVRDRGFLDDGDRVLHKLIKYESKMVGFVDFFCIKDVRIFSAIRQNIQALAFELRQKSIKSYASFLFYIFYGKIHVCDWMKILIRLLINAQTLYSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NAY4</accession>
    <name>A0A162NAY4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_158973</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290758.1">
        <property type="nucleotide sequence ID" value="XM_018433891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NAY4"/>
    <dbReference type="STRING" id="763407.A0A162NAY4"/>
    <dbReference type="GeneID" id="28994797"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_158973"/>
    <dbReference type="InParanoid" id="A0A162NAY4"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD72718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="269" mass="30071" checksum="CF4F5A6BD0B15204" modified="2016-07-06" version="1">MVKIGQGASGGVYTSYRTGTQTLVAIKQMNLEKQPKKELIINEIKVMKQSTHPNIVNFIDSYLWKGDLWVVMEYMEGGSLTDVVTCSMVTEGQIAAVCREVLEGLKHLHANGVIHRDIKSDNILLSLQGDIKLTDFGFCAQLGDDQTKRTTMVGTPYWMAPEVVTRKEYGAKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPQLQDPDSLSPIFQNFLSYCLEVDPDQRPSAAKMLRHPFLAKAEPLRSFAPLIRAARERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NDH3</accession>
    <name>A0A162NDH3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_181494</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291358.1">
        <property type="nucleotide sequence ID" value="XM_018438477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NDH3"/>
    <dbReference type="STRING" id="763407.A0A162NDH3"/>
    <dbReference type="GeneID" id="28999383"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_181494"/>
    <dbReference type="InParanoid" id="A0A162NDH3"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF489">
        <property type="entry name" value="RING FINGER DOMAIN AND KELCH REPEAT-CONTAINING PROTEIN DDB_G0271372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MATH" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="113"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="86"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="310"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="325"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OAD73318.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="56566" checksum="0CAA610598697B01" modified="2016-07-06" version="1">MDTDNVEEKIANGRGYDQFITLQDVQNYLTDDQLTLSINLTINQTHKNSLRGPRSYPKPQPLKFYAEDLENFQDVIIHVFKDENNESDKNESNLNHGSTDSINKNENKKVEDTEGTISNEKTTLHGHKFILATASPWFRDIFLSGMKESTDNEVKIHGVDPKIFKLIFDFSYGNDIYIKDSIHGISILKVADRLQFKRIKKYAFSCLRAQIKNSNIFDIWEASDLYDCDKTRKLCEKYMRSNYADIFVSPEWLATSDVYALKAINIDGLKGRMDETVFYKAVLSRREAATQEVINLRKAKEKELEDNMLKAQLGNPTPSGDNESEVVKGLDEGAKDPREGAKDSEADDKNSEDASREDTGEKGKEDSKNNGNEKMDTNVKATDNGWEDLPENVKPVVETEEEKLERLENIRWEEYIKEELEAIQKHFETMIRYIRFPQMDIEFLADIVEKEDAVMQLPGIKDILIESYRHKAFLGKREVSKKYQSRTIESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NJF3</accession>
    <name>A0A162NJF3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_158512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NJF3"/>
    <dbReference type="GeneID" id="28994708"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_158512"/>
    <dbReference type="InParanoid" id="A0A162NJF3"/>
    <dbReference type="OrthoDB" id="5596610at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="82" mass="9878" checksum="998077249EE2A231" modified="2016-07-06" version="1">MTKRVQFSCDVKFVNTFDNDEYDRTAQEVAKLTYKDMVELLTMKSQWRREMERMLAERAAGEKRDDDRDEPPRLFVSCEIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PI77</accession>
    <name>A0A162PI77_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_71574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD73097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291137.1">
        <property type="nucleotide sequence ID" value="XM_018442505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PI77"/>
    <dbReference type="GeneID" id="29003411"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71574"/>
    <dbReference type="InParanoid" id="A0A162PI77"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="196" mass="22851" checksum="F87F96AE3D1B5565" modified="2016-07-06" version="1">MQISPAKLFVTFANCIVFLNDAANLPTNAVEKLRLELQHRKEFEIRFAKEFNLQQKVVENMAEAAYNFSNTEMKNKRKLDRENYRRKEIIDSYNSMGPLEKGRYYEMTKENSTTLHQEFSVPDVNRAAKSILTIMDTMKLLMNYDSLFLFWKSDASSSRKIDRLLSGDMSSIFFKCIEKDGALKSFLEALGNVKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PKN4</accession>
    <name>A0A162PKN4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_186899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291767.1">
        <property type="nucleotide sequence ID" value="XM_018439298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PKN4"/>
    <dbReference type="GeneID" id="29000204"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_186899"/>
    <dbReference type="InParanoid" id="A0A162PKN4"/>
    <dbReference type="OrthoDB" id="786951at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039249">
        <property type="entry name" value="GPATCH11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF0">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="63"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD73727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="257" mass="29285" checksum="E141E78BCA446379" modified="2016-07-06" version="1">MSSDEDDYMSTKFLEADATNQQLTYSEKRRKHLHNQQIKSYIKPRAQLEQEAREEGLKKAMDSENKGMKLMMKMGFKTGMTLGKSSTAGIHEPISVEVKKGRQGLGMESSVKRARDEQEAQEVKEAQEASKRVALDPMAYREAMAERAKEGKLTRRIGACASLCKKLDEETGVESNILWTLVPKPVTEGEDKSEETYEDFYPAEALKALKELSSTDKLDRIIAYLRDKYVYCFWCGARYDSPEDLKENCPGEQEDDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PLG3</accession>
    <name>A0A162PLG3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_172041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD70026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288066.1">
        <property type="nucleotide sequence ID" value="XM_018436720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PLG3"/>
    <dbReference type="STRING" id="763407.A0A162PLG3"/>
    <dbReference type="GeneID" id="28997626"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172041"/>
    <dbReference type="InParanoid" id="A0A162PLG3"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD70026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="161" mass="19010" checksum="CACB039EAB8B79A2" modified="2016-07-06" version="1">MERFREKINLIRIEADAAKAKAEEYEAKVKEYEKIKMDQEHEIISLTNQNKKMEDDLEAALENIKRLKSIEDEGGDLKKENDAAQRKITLLEQELENSDKSLRETTKNFREADVKAEHFERKVQQLENLLLEQERKGEELKLKNHELQAQLDEFNAQLDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PU45</accession>
    <name>A0A162PU45_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_145460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292036.1">
        <property type="nucleotide sequence ID" value="XM_018431447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PU45"/>
    <dbReference type="GeneID" id="28992353"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145460"/>
    <dbReference type="InParanoid" id="A0A162PU45"/>
    <dbReference type="OrthoDB" id="165382at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF82">
        <property type="entry name" value="NIPA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="348"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD73996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="54126" checksum="6088C2D9DABD18E5" modified="2016-07-06" version="1">MAGGDSVTNFVIGIFVSLAASFLDALGLNILKLDHVKESKRDADQQRNDCGRPLWHIGLYTYIGSQLIGSTIALNYLKTQWVAPLGSAALIYNFIFAKMLVNTKITRKDVLGTCVVVASVIWIVVFGGMYNGDDPEENISLENLKTLFMRPIFIIYFSALNIITISGLIFAIWSRWALADSSRKRRNPLFAGMKDKKMRRLIGLMFSLDGGMLASETLLLAKSGVKLFTLSVSSQVNQFTDNTSRFVILALIVTAVLQVYCLNSALKLYSSVVVVPVFYGTYTALGLVNTIIYLDEISHYPGWAIALVFGGIGVLIYGVYLLSSKPDPSHPQEEEAEIEQEMNVLNPTSLTSDSTAWPTAKEEKEAAERRSIPLGLGESSGSHQQLPLDNESLFGETVKPISPPLPPPSRPFMRWIHRIKQSLSSNKPESPSINHSSSGITMPLVAQTRQRAVPHETQHTPNHHEMLYYPDLEQRSHIGLQDTASSGLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PWH7</accession>
    <name>A0A162PWH7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_61155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292836.1">
        <property type="nucleotide sequence ID" value="XM_018440760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PWH7"/>
    <dbReference type="GeneID" id="29001666"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61155"/>
    <dbReference type="InParanoid" id="A0A162PWH7"/>
    <dbReference type="OrthoDB" id="2438399at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="104" mass="11724" checksum="E719502461ACE642" modified="2016-07-06" version="1">MLVFGSGMFSKDGVKLRGHRCGVVGKLYKVLKKQETEGQLIVITISEFKASKTCSLCFFGDKKIIKQNRLKVLPLYLENNNMISISKSIWSGEGRPDVFIPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PXZ5</accession>
    <name>A0A162PXZ5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_142541</name>
        <name evidence="3" type="ORF">PHYBLDRAFT_142543</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295067.1">
        <property type="nucleotide sequence ID" value="XM_018430828.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295069.1">
        <property type="nucleotide sequence ID" value="XM_018430829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PXZ5"/>
    <dbReference type="GeneID" id="28991734"/>
    <dbReference type="GeneID" id="28991735"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_142541"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_142543"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD77027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD77029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="117" mass="13254" checksum="9B829C703A560193" modified="2016-07-06" version="1">MLYQQYGPVRIGRLLSSIWTEGIFPTILGRRNPEDNNINLSSPPIKADPSSTGRRPVLTSWKRTEWGGDRERWGVRLAMGLKNKREGKLNYPTPTTPTTPTTPPIHTTPTPIHPTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q348</accession>
    <name>A0A162Q348_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_162622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297606.1">
        <property type="nucleotide sequence ID" value="XM_018434665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q348"/>
    <dbReference type="GeneID" id="28995571"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162622"/>
    <dbReference type="InParanoid" id="A0A162Q348"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD79566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="206" mass="23118" checksum="E2C132C9EF0CE32E" modified="2016-07-06" version="1">MFFYMSKRIKSMTPSSLSPHYAAQSPSGRKPDLVAKEMLEWWQTNGKHPFIQPHISSPSNVGANSPENLPLGDKVQLIRLPVASPSAVKEFSQVSSEEPAHLTTGYSKLVCALLVQEHNRKCFILLIQVGTKGAQKLLGNKPIYIVKQYSAIINLLTIFVNCRKVFTINVVLYYIKDRVLCIDRKNMVISKSVQAVYKSSQFGKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q4E1</accession>
    <name>A0A162Q4E1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_184995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297996.1">
        <property type="nucleotide sequence ID" value="XM_018439013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q4E1"/>
    <dbReference type="STRING" id="763407.A0A162Q4E1"/>
    <dbReference type="GeneID" id="28999919"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_184995"/>
    <dbReference type="InParanoid" id="A0A162Q4E1"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="2">
        <location>
            <begin position="62"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="2">
        <location>
            <begin position="180"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD79956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="342" mass="38927" checksum="ECE97BDA557C35B0" modified="2016-07-06" version="1">MGVSSPSSTTTPLTPITITSGTSFKRRYKACFTKRQLATLTSLKKSAGLAAKEATARHASCKFIQDVGKKLGFPQTTISTAQALYHRFYVYYSIREYAPQDISVTCVFVASKIEETIKKLKDVFVAVHSVKYPGSKELDPENVSEERRRKIIGYEKLLLETLCFDFQFRHPYEYVIKFVKWVQAFQTLDAKRLAHKAYSLAVDSYRTSLCVEYPAHTIAAGCIYLASRLLKEEDPEFHGLAEEQPWDQLLLSRIDDIEDVCQQILDLYICSGAHNATAQYTRIKIELNEQAHRRGPDPNMDDVTRQEMKARTPDWEFDGTTPLDVVNTNQHTVSYHFSTNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q5L2</accession>
    <name>A0A162Q5L2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_160943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298336.1">
        <property type="nucleotide sequence ID" value="XM_018434320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q5L2"/>
    <dbReference type="STRING" id="763407.A0A162Q5L2"/>
    <dbReference type="GeneID" id="28995226"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160943"/>
    <dbReference type="InParanoid" id="A0A162Q5L2"/>
    <dbReference type="OrthoDB" id="2286841at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF34">
        <property type="entry name" value="NOTOCHORD-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="399" mass="45684" checksum="C545864A7B63D2E8" modified="2016-07-06" version="1">MKEHYKIAAADPTHKEKAIPGILPNADNLYLKMEKPTNKALFLLILDIVILSFDPALDTPVEILHTVALGVCKYLVNHLFKEVLKGNTASQVKLSDLLEQKKGSRDFTRTFRKKLRHSGSYLGKEFKILVQVLPPILNTEFTDNTEVKVDSDFDQYLNNVDNTACRLVKPLYEYDIYANTKFSLTLKTHLLLHLKEDIKRFGCALHFETEKGKQFNKFIRTHLVYSNRHADNRDLALKFGKQDMPRHIASGSSWIDKCGSDIFALLHDQGIKFSDNFFGKHQEFVDNNHVKTKIVAGVSVAFSYSNNANRMFVGRVVESNSVLRIQHYQLFSPNLNLVTVGCQPIEHYCNLEDVKIECMLHLTSGSETQNYHFYTRISLGVIHSILPLKNYILQKSHDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T1F3</accession>
    <name>A0A162T1F3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_176077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441010">
        <property type="protein sequence ID" value="OAD65482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283522.1">
        <property type="nucleotide sequence ID" value="XM_018437646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T1F3"/>
    <dbReference type="GeneID" id="28998552"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176077"/>
    <dbReference type="InParanoid" id="A0A162T1F3"/>
    <dbReference type="OrthoDB" id="2431110at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD65482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="704" mass="80096" checksum="926834A03BCAC52F" modified="2016-07-06" version="1">MNDITILQQMAEILLGFDQKNGGYGPTFGPTAIHSAVVSVGANKGYSLVTSRTAEHHIRKDELERIERLDMAERLANTVQEEQMMDVDTQYDQANSPDLNAATMADNVSVDNEISEVNGNDSDIERDMNSDSGSGEEEGVETDVEEFVNEDPFDAPNMPENPVHWFIATFAVLFISRYVVNKGAAILIEFINQLLKIYGKDFQLPTSLIGLQRMTGFSNYANGIKKSVVCEDCHKVYKQDVPLPTHCDFKKHGSQSACNCELMKVSSSGAMVAKQSYVYNSIQRSLQLYRLGYFDLVRGMIIDPMHNLFLGTPKRMMERWIKEGLIDNRKLATMQTMAETMVVPMDYVVLKSKIGKGFPYMKADEWKSWVLVYSPILLKAVLPIEMFRNWISFVDACRQLVKPSITFSDIDNGHKFLQEFCTECQRIYTPTILTCNMHLHLHLRETIRDFGPVYGYWLFGFERYNGLLKNVNTNRKDSFEVTYMNSFVQDTFKGDFVHAALTCPSQVPFLPLLAKLTVTAQPSTSKNTITFPQRPFRLSAFIQAYSNPSLPVLGNEPLPPSAFPLHIEPPSAMSDVDYPHLLDYYKVAYCMPNLEGNNWLAYTGQIQYLFLHSFTPPVDNTELQTRVVYQDKHVFAFVKWFQIEHDHSRELESVDICSADFIACNFECILPVHRISSVVATCDYKTSTNNKKILVNALPHKQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T8R5</accession>
    <name>A0A162T8R5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="3">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_151859</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="3"/>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD66922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284962.1">
        <property type="nucleotide sequence ID" value="XM_018432764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T8R5"/>
    <dbReference type="STRING" id="763407.A0A162T8R5"/>
    <dbReference type="GeneID" id="28993670"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151859"/>
    <dbReference type="InParanoid" id="A0A162T8R5"/>
    <dbReference type="OrthoDB" id="7773036at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF2">
        <property type="entry name" value="CATABOLIC L-SERINE_THREONINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="8">
        <location>
            <begin position="22"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="405"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD66922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="417" mass="45234" checksum="09C518454CAD6C5B" modified="2016-07-06" version="1">MIEDSSDEENQLLDESQTMHVGTPLLHSSRLSVKLNRFSKMSSNIFLKMENIQPSGSVKMRGIGNFCYRTVQLRGTDIRFICGVGINTALAVAYCARQLGVDAVIVLPKNTNESICDGVRLEGAHLILFGDDFTASESHARKLLKRNDVYVPSSDHAHIWQGHSTLIHELKSQLQNNPPAAIICPVGGGGLLNGVIMGLQEIGWKQVPVIAVETHGSNSFQSAVVAGKMVTLPRLTTIASSLAVKSVSSKSLELSLVHPVVPFAVSDAMAADAARLFADDNKTLVEAAAGAGLSLCYTQIIRDILPSLSPESDVVVLVTGGSDISLEKLEEYRKKYKRPPVVVKSGSEVFLKMDDSLTNVQEVNMDEPSGISKKALKDLSARHTYKTEVMEDLTMQQAQDEEESYSSAKTPTPLQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TDH2</accession>
    <name>A0A162TDH2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_175316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441004">
        <property type="protein sequence ID" value="OAD66263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284303.1">
        <property type="nucleotide sequence ID" value="XM_018437467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TDH2"/>
    <dbReference type="STRING" id="763407.A0A162TDH2"/>
    <dbReference type="GeneID" id="28998373"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175316"/>
    <dbReference type="InParanoid" id="A0A162TDH2"/>
    <dbReference type="OrthoDB" id="2448307at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF1">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="193" mass="21910" checksum="BEE7396A55CB7795" modified="2016-07-06" version="1">MVSMEKIITRVTETRWSKLYISTASLQCIIIIVLQSVICYQNSTQTSFLPESNHTKTKEMTIAVAAFDRLSRIKWENVSFIGFQLWFVGMAFDATVYQNTAEILALAILNVLCAVLGALEVVDGYKWMRLLAETSFSTIPLSIARDIEIALSIVIMLFACAMCYLSFAMSRQFGWNIYKKIGADIQIQRKYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162THP5</accession>
    <name>A0A162THP5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_188639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286712.1">
        <property type="nucleotide sequence ID" value="XM_018439541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162THP5"/>
    <dbReference type="STRING" id="763407.A0A162THP5"/>
    <dbReference type="GeneID" id="29000447"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_188639"/>
    <dbReference type="InParanoid" id="A0A162THP5"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="2">
        <location>
            <begin position="387"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD68672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="469" mass="51852" checksum="BAC8E9E98ED24D5E" modified="2016-07-06" version="1">MMRKQESCCLDRVPQETMTEERLFHDKTLSRSPARPKPIPNGNKLMQHRDQIHSSPSNSLISSSPWSIVSNDAFNQDESGEVSTPLSETGSNSKGGSFEFMNSPRTTRSFGCFSNSPAGTKDRAIAVVPTPHSRQKISLGWTTPSNDAASMPISSATIHRPQNIDNPRQDKTGSYNSDKSIASFRSSHQKSTRQAPARSGIAIARAKQEEMEEDDGFQLIRATFSNAPKESNSKNDASLEWISRPLTPSKNSPQKYSFITTATDIHINNGSPVISPKILYKPSRTSRQISSCETSCSSSSVKSHDENLDSDDPNFNEVFVHTSPSSFAPPIDSFLRVSNLDQCTIYSTDTDPKALSAHQKKHLKPTLRIATDACCTQILKPTLLQSLLPNTVADGRYETLFDTIQDQGIVDGELVKALWRKSHIPDRILGHLWDQCDPSHQGLLDKQAFIQGMRAIDAFLLQHSQAVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TSD3</accession>
    <name>A0A162TSD3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_188465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287433.1">
        <property type="nucleotide sequence ID" value="XM_018439513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TSD3"/>
    <dbReference type="GeneID" id="29000419"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_188465"/>
    <dbReference type="InParanoid" id="A0A162TSD3"/>
    <dbReference type="OrthoDB" id="10319930at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007839929" evidence="2">
        <location>
            <begin position="24"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD69393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="506" mass="57475" checksum="758AE8CD952672C6" modified="2016-07-06" version="1">MFLRNNLLILCILLVEFVHRCRAPPVEQEEADPFAIPPALEILKTIVLGYMAHVLTVRPETGIGPYSTESRRLGCFAFPVMGIGFAAQSIYFAIYGDNILGISKFKQMLKKYDEETRNSYAKGGENINVNPGSSLFSETFKSNNQKEFNATHQTSNVESFLERTSSLRDWLVESMRANGVYTKEYDNAPYLAALLHTMDPKDAKKVKQCILNENILLGFDSSTYKPLKEHFVKVTKDLSVSGPGSLAEYQTTVRPSYVRYLSISMLNQLTASYNVDDTSYFEVCVTLGQIFFTVVECMEIDGDKWAKVVMIIYTAMSVFQVTSLFALHKQSMPFTVYYDQDLSWQKLIEDRGIYVIKDVKRILFPHKYAPKPLTPTGIVYSGWVYPTSCVLFILERREFELDRRRLLIDIYGNRVHGIFSILGMGVSPLVCIWADYKSQSITKWLVIGWMVAPVVFHCGIAIQNGTIGYNFLVRSTWFIFISLLSLGCLLTATVFGYIPDYANSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U0I2</accession>
    <name>A0A162U0I2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_159404</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289383.1">
        <property type="nucleotide sequence ID" value="XM_018433983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U0I2"/>
    <dbReference type="STRING" id="763407.A0A162U0I2"/>
    <dbReference type="GeneID" id="28994889"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159404"/>
    <dbReference type="InParanoid" id="A0A162U0I2"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24206">
        <property type="entry name" value="OS06G0237300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD71343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="71" mass="8067" checksum="A379F8100C64F5D5" modified="2016-07-06" version="1">MDCSICLKTVYFVEKVEANGRPYHKSCFKCTESGCRLTLANFHYCEGRLFCPKHVPKLQAIVRLGIIQEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U657</accession>
    <name>A0A162U657_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_73360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290673.1">
        <property type="nucleotide sequence ID" value="XM_018442840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U657"/>
    <dbReference type="GeneID" id="29003746"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73360"/>
    <dbReference type="InParanoid" id="A0A162U657"/>
    <dbReference type="OrthoDB" id="2289420at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="114" mass="13085" checksum="754C4EBDA9AE4534" modified="2016-07-06" version="1">MRKLRISNINNLKYSATHGNKKFAHGATELIRTMEAKARRFSDIFIMDAIRKTNCVKMSLVCVEGVSNLGGERLKSFLVLDAIVLLETKELVPINRPKILDYIAKMKIEIHVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U7J3</accession>
    <name>A0A162U7J3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_181719</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD73013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291053.1">
        <property type="nucleotide sequence ID" value="XM_018438511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U7J3"/>
    <dbReference type="FunCoup" id="A0A162U7J3">
        <property type="interactions" value="296"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162U7J3"/>
    <dbReference type="GeneID" id="28999417"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_181719"/>
    <dbReference type="InParanoid" id="A0A162U7J3"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="139"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD73013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="413" mass="45436" checksum="89D03E66C4D4FE40" modified="2016-07-06" version="1">MARQYAQRFATASHLLRFGPSETLLPSITCLRPKWSANRLLTLNTPSQQQKSIHYATPLTETPLFLTSSGNNRSKVPLQSLTQSRNLTSSNTAHDTPPTGELSQEEPQTTTEGFNFFAYASWHAKNRAPKEKQKESKTPYWKRSKVGKVDAGEDAFFHTYTPKGMALGVADGVGGWADVGVDPALFSWTLMNNAAVVAKAENPVDAHHILDSAFNQLRVGGKVPAGSSTACILNLCKVTGQMTTCNVGDSAFLLIRDQKVVYESPSQQHYFNCPYQLTVVPDTYPDRDNYVTDMPKDGDQKSFFLKDGDIIILATDGYFDNVYSSETLALVNSTMSRLTDATEEDEVVTTVRGLVKTLTDTARRLSLDPKRLSPWARAAQAHGSHYRGGKVDDITCIVTLVKGVHPDPTPQDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UH90</accession>
    <name>A0A162UH90_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_132281</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the actin-binding proteins ADF family. Coactosin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294262.1">
        <property type="nucleotide sequence ID" value="XM_018429482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UH90"/>
    <dbReference type="STRING" id="763407.A0A162UH90"/>
    <dbReference type="GeneID" id="28990388"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_132281"/>
    <dbReference type="InParanoid" id="A0A162UH90"/>
    <dbReference type="OrthoDB" id="20822at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11282">
        <property type="entry name" value="ADF_coactosin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000018">
        <property type="entry name" value="Coactosin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF56">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="2"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD76222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="149" mass="17013" checksum="D1E1966817160D3E" modified="2016-07-06" version="1">MALNISDPELNQVYEDVRDDKTETNWSFFTFADGKPDRLIVAGFGSGGLEEFTKELKPEIAGWGYLRINLSNDEYSQRIKFVLVPWCGESVSVMRKAKLGIQMSDVKNIIRNFHIEVPASHVHDLDEKEVLTRLRRAGGANYDRQSSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UJB5</accession>
    <name>A0A162UJB5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_157963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294662.1">
        <property type="nucleotide sequence ID" value="XM_018433705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UJB5"/>
    <dbReference type="GeneID" id="28994611"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157963"/>
    <dbReference type="InParanoid" id="A0A162UJB5"/>
    <dbReference type="OrthoDB" id="2268597at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="81" mass="9105" checksum="1CA02B8299464C62" modified="2016-07-06" version="1">MSDSKPMFLSVDDERKLTYDLMRSTDDASEPAVAKEVRHPHLQEIKETLYSLKESAKNTLAGHGDSTQEKVPQDGKTNPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UJK8</accession>
    <name>A0A162UJK8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_142753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293793.1">
        <property type="nucleotide sequence ID" value="XM_018430864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UJK8"/>
    <dbReference type="STRING" id="763407.A0A162UJK8"/>
    <dbReference type="GeneID" id="28991770"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_142753"/>
    <dbReference type="InParanoid" id="A0A162UJK8"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="249" mass="28661" checksum="F3154E3ED827DD96" modified="2016-07-06" version="1">MTHYLLKHVWGRNYNVPLKSPSLIIHWCCGTGIWCLELAEEFPDAKVIGIDFKTAPLQNIAETRTNLTFQDITICEGHTGLEGYPDNAVDYVMMRDVWIVNSPIHKWHNILKQVLRILKPGGWIEIIEQDIRVSKPGPSFVILNKYGNMFLENIQARPGILEELEDMLKDTGYTNINSTIVELPLAMRESGYLFKDLSERRFRVFAPWICEYNQLPASVFAETLSKAMDECETSKSRISWHCFLGQKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UQ28</accession>
    <name>A0A162UQ28_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_60536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295442.1">
        <property type="nucleotide sequence ID" value="XM_018440657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UQ28"/>
    <dbReference type="GeneID" id="29001563"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_60536"/>
    <dbReference type="InParanoid" id="A0A162UQ28"/>
    <dbReference type="OrthoDB" id="2402233at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="83"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD77402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="128" mass="14520" checksum="10DB9FD2BB6CC5C9" modified="2016-07-06" version="1">MSLYIYNSITTIAFTKITKIKSLKYNRSSLNIKKKKKKKLSMSNPQLAEWAKETFGFQKALNVSTISKILKRGDQGLIMQANQIEEAVILLIKIAENNQIPITWELIKTKATIFAKRIGVKDFNASQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UT06</accession>
    <name>A0A162UT06_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHYBLDRAFT_95968</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295763.1">
        <property type="nucleotide sequence ID" value="XM_018443936.1"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UT06"/>
    <dbReference type="GeneID" id="29004841"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_95968"/>
    <dbReference type="InParanoid" id="A0A162UT06"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF45">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8 12" id="KW-0518">Myosin</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="830"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="870"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1138"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1533"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1560"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1588"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="16">
        <location>
            <begin position="1"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="15">
        <location>
            <begin position="893"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="12">
        <location>
            <begin position="563"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="727"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="798"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="755"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="799"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="89"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAD77723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1659" mass="188578" checksum="B610B7204ADBC17B" modified="2016-07-06" version="1" fragment="single">DLTLVHPINQDTLISTLKIRFDNDIYYTRISDIALVAINSYKSSFTADYVTEYKDTAEHSLPPHVFQLTNQAYFHMRRTGIDQSILLSGEPNSGKTEQEHLILQHLINLSSFKKEKRSLPLLEARQIIEFFGHCRTTANPNASRVEKYTEIQFNARGKMIGCRLKTYLLDKNLLRCTSPGDHLFHVFLAVFHCSAQDRHLWRVLDPSQFAYLHRMSQTMLVFPDAEQHYTNFKAACRALGWGKRQYLKIMQVVAAILHLGNLQFVDDVQQETAHAKNIDILTLCADLLGVDARALENVLTYKTQWVKNDLTTILLNAHQAAEQRDCLAMTIYGRLFDWLVDAMNTKLNNDSAAHSTLGVFPISHHQSDGTFHSFCLNYATERLQQVFLRRIYETEPIEYSREGIDGPEPVNQSACLDLLVRPRLGLVDIIQAHSTRRFPNRTDSLWEILAKQHQQSDLFRVVNEPSRSFVIQHYHGAVAYHPQQFLEDNREVMNSDFVGLFRASLDSPGSQNAFVARLFEDQTLNTGMYPQRSSSTRVKHSTTNEASRQENEGTVLGQLQTTVDDLTRSMESTCVWSVLCIQPNDSNTPNVFDTARVRHQLRAHGVTSLTERLVQNYTIGFEHEVFCQRYTDALQCIGIKGPYRTQCETAAVMLGWSTSQVAIGHSKIFLSESVWRHLEDGVRTLEKDQQRQNKSSLSYPAIRRDMSADALSRVSYSSGDLLTSLSEDSAVDRRSPPNHPQLSRQLEPLSDRTDNQSFASEETAIPTDSNPQDDAEKNVLSGLHDVLPLGGMDANAGLGVAGTGGNGNGETGNGSSPQEAEQVSVVRKRWVWFVWAMTWWVPSPCLQWCGRMKRADVRLAWREKLTLCMIIFLMSGFIIWFLVFFGKLVCPHQDVFSQSELQAHNTKKSAYVAIHGEVFDLTKFAPHHWASDVISTQSVLAYAGTDVSDLFPVQVSSLCEGVNGALSDWISMDFHVNLTDTNAKYHDFRAWSGDFRPDWYFEKMVYLRRNYKIGTMGFVSKDVVLQATNPVSLGGMRATRNWAILNNNVYDLTYYIMGSRRIQVPDGQPMPANVDLNFMSDTVVNLFRQKSGTDITNYWNVLPLDPDVRQRQEVCLRNLFYVGTVDQRNSIRCIFSEYLLLIVTIFLCLVIVFKFLAALQFGTMREPENHDKFIVCQVPCYTEDEESLKKTIDSIAALKYDDKRKLLFIICDGMIIGGGNDRPTPRIVLDILGVDSTIDPEALSFLSIGEGQKQHNMAKVYSGLYECSGHVVPYIVISKVGKPSERQKPGNRGKRDSQLILMRFLNKVHFNAPMTPMELEIFHQIKNVIGVNPAFYEFVLMVDADTEVLPDGLNRMVSSFVHDSKIIGLCGETVLSNEKDTWVTMIQVYEYFISHYMIKAFESLFGSVTCLPGCFCMYRVRSPSKNQPLLISNQVIEDYQINKVDTLHMKNLLHLGEDRYLTTLILKHFPNYKTKFIPDAQCATNAPDQWSVLLSQRRRWINSTIHNLGELVFLPQLCGFCCFSMRFVVMLDLVSTLVQPAIVGYLIYLIYSLVTSTDGVPVMSMITIAGVYGLQAVIFILHRKWEHMIWMIVSIFAIPVFSFYIPIYAYWHFDDFSWGNTRVVVGDKGVVVVVAADEGTFDPSSIPTLSWEKYEEGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V1C8</accession>
    <name>A0A162V1C8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_162417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297383.1">
        <property type="nucleotide sequence ID" value="XM_018434614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V1C8"/>
    <dbReference type="STRING" id="763407.A0A162V1C8"/>
    <dbReference type="GeneID" id="28995520"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162417"/>
    <dbReference type="InParanoid" id="A0A162V1C8"/>
    <dbReference type="OrthoDB" id="3248986at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD79343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="640" mass="73854" checksum="AEC2D27BD796B538" modified="2016-07-06" version="1">MSNNQKKDSYVICKCPDLSVAKDDAIDVPEEHFDNMEVDNIDSDNDNDYDYKNEGKGEYKDENEEQNIEFDQEVDLPLSQEESIFTAKDTVTEAFMVDGNEIEEGNTDFDFEQEENFDETSGTSIVESVRPLSFDNTPLYIRFVAVFIVIFHLICLVESSGSILIEFCNTLLSLYDLSGALPLTINSLKHKTGFNMTTDGMTVYIACSQCHSIYPLKTKLHRLSYFDPVHFTVIDLMHNLYLGTAKQMIQIWHECNCINEKNQLTMQELVNGIVVPCGYHVLPAKNLENWILFADACHLLTKPSINDKEIDEAHSKLQLFCTRFQTLYGKSAVTLNMHLHLHLGKCVHDFGPIYTFWLFSFERYNGLLKNIETNQKGCFESMMMKRFLERTYIGSFIQSFVNHLPQFAIDFLHCISNSQDQLAALHSSSTASTFSLSDFVEYSLNSHHSALGCEPLPPSVFLIKLNQRIIMCKGHYECLLEFYRHAYSSHNFFGHYSNWESNQIFVNNRIEKMKWISLLGQEYSSGSYFRAYYLENNSEDKAAFPGHILYLFQHLITINETVITHTFAFVEWYSSYSLGSYQPMLNEGIELWNESSSVLNYECIIPVHRFYSPIAIAKYRFTITSEFKRLVIPLPQKIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V3B0</accession>
    <name>A0A162V3B0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Exonuclease 1</fullName>
            <ecNumber evidence="13">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHYBLDRAFT_121316</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">5'-&gt;3' double-stranded DNA exonuclease which may also possess a cryptic 3'-&gt;5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="13"/>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297702.1">
        <property type="nucleotide sequence ID" value="XM_018428790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V3B0"/>
    <dbReference type="FunCoup" id="A0A162V3B0">
        <property type="interactions" value="322"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162V3B0"/>
    <dbReference type="GeneID" id="28989696"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_121316"/>
    <dbReference type="InParanoid" id="A0A162V3B0"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09908">
        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000002">
        <property type="entry name" value="Exonuclease 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037315">
        <property type="entry name" value="EXO1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF8">
        <property type="entry name" value="EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0228">DNA excision</keyword>
    <keyword evidence="11 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 13" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="7 13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="15">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="14">
        <location>
            <begin position="138"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU910737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAD79662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="311" mass="35660" checksum="EEFB64D3A4ED5887" modified="2016-07-06" version="1" fragment="single">MGIKGFLPLFKQVQEEVHIREYGGVKVAIDGNVWLHKGAFSCAYDLATNRPTRRYVEYFIRQVDMLLYHKVIPIIVFDGKPLPIKSHTNDQRSKDRINAREAGYELKRQGNTRAATEQFQKAISITPEMIAQVSKALAIRKVQTIVAPYEADSQLAYLIKHNIVEAIITEDSDLLVFGCKTVLFKMDRSGTAMRLRQKDLPLTTEINISGWDIDKIRRMCILSGCDYLESLPGIGIKRAHNYLVNFKTYEAVLARLRIEGKMKDTKNYEELFEKAEKAFLYQHVYDPITKEFVTLNPLPDNIPIETLDFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V3Y8</accession>
    <name>A0A162V3Y8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CYP5206 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_157337</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297823.1">
        <property type="nucleotide sequence ID" value="XM_018433602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V3Y8"/>
    <dbReference type="STRING" id="763407.A0A162V3Y8"/>
    <dbReference type="GeneID" id="28994508"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157337"/>
    <dbReference type="InParanoid" id="A0A162V3Y8"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF11">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="1 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD79783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="526" mass="59069" checksum="740A4D9109B4867F" modified="2016-07-06" version="1">MDREWLKLFFEENYPTQASGVVAAAVTVILAYSIHSLVSLRKKNVAVWHRKGYMEIPTPKDSYPYFGHMLSLGKKPFLQLEKWHQELGPVVHIDMGIQPWVLISDPYIAHELFVKNEVKSSDRMRHAFTYDVYSKGGKGIVFIPPNQEWKNCRTVADTILSTENIKNFVNIIEAVTDNTINRLKEVSEKDGSVSPVKYIQKAIFGIMISLLFGKTPGSIEDSLLDSIICMAENELRLAGPSGDIGSFLRYSSWVNTVTRKNKEIKSVVDTRDKVYGELISEAIAGETDCLAKQANLLKEKYNLDEMDLIIIMDELIGAGGDTTAASASWLFAILPRYPDIQKKMGEEIDKFIAKNGRIPTFSDRKELPYVIAVLRENLRYRSVTCLGLPHLAAEDVELLGYYIPKGTVLISSMPALNMNQDVFDDPKEFNPERFLGDTSTWSESTQGDIQSRNVFAFGWGKRSCPGVNLAEMNVFNICVRTFAHYTIEPTLGTDGKPSYADLNDILSLGTLYGPNEFSVKIVKRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WLQ2</accession>
    <name>A0A162WLQ2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_78641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286945.1">
        <property type="nucleotide sequence ID" value="XM_018443379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WLQ2"/>
    <dbReference type="GeneID" id="29004284"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_78641"/>
    <dbReference type="InParanoid" id="A0A162WLQ2"/>
    <dbReference type="OrthoDB" id="10650638at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48148">
        <property type="entry name" value="KERATINOCYTE PROLINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48148:SF2">
        <property type="entry name" value="PA14 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007840821" evidence="2">
        <location>
            <begin position="20"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="668"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="745"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD68905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="841" mass="88140" checksum="8C26741A29EF24F7" modified="2016-07-06" version="1">MRFSLAAIAVLSLSNLTFALPSFPEEAASASAYEVASASAAAYSPASASVQGSYAKVGSKRNIIEFFKNLMYFEEPTALESSLAEENVLEEVSEASASAYQSASAYAKRGFLNDPFEFFPAEASAAYGAIPLASASQAAGSMVAYAEDFSVATNTDSVPFAASNDQILNKRGIILNFLDSLFDDLSPSSSSSSSEPAPSSDSSLLKKRGIFLDILEDLVDDLSPSSSSSSSEPAPSSDNSQPKKRGIFLDILNDLVDDLSPSSSSSSSEPAPSSDSSLLKKRGIFLDILNDLVDDLSPSSSSSSSEPAPSSDNSQPKKRGIFLDILGDIVDDLSPSSSSSSSEPAPSSDNSQPKKRGIFLDILNDLVDDLSPSSSSSSSEPAPSSDNSQPKKRGIFLDILGDIVDDLSPSSSSSSSEPAPSSDNSQPKKRGIFLDVLEDLVDDLSPSSSSSSDSSEPSSSEGGLLKKRDALEDFLREFFSDIDFDFPTESASSSSDESAAPTDDSASAPADDSAPPPPPTDDSVPPPADDSVPPPADDSVPPPADDSVPPPADDSAPAAAPALNKRGIIINFLDELFGEAAPEASVSASASAYSVDNARFEKRDFFMDALDDIINDVLPIPLSSSASESESASPASASPASASAYYADAVYKRDLFELIEDLFEDDSSSSQSESASASEPESSASAYAYPAEAYYKREIIGDLIDAVTDDKPSDSSEDEEADTEEAQPAEEDNSAPAEEEESEAPADSASESASSPATEASEAFVDYGVMEESYQDNLDAQMMAEDVAYLDTLPSMNFEKRAHHNMNRMASASASASVASFASAAYADSDVYMEALERMNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WYM5</accession>
    <name>A0A162WYM5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein 60S</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_177787</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289595.1">
        <property type="nucleotide sequence ID" value="XM_018437928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WYM5"/>
    <dbReference type="FunCoup" id="A0A162WYM5">
        <property type="interactions" value="493"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162WYM5"/>
    <dbReference type="GeneID" id="28998834"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_177787"/>
    <dbReference type="InParanoid" id="A0A162WYM5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD71555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="10888" checksum="AD9CC4C8D62294BC" modified="2016-07-06" version="1">MKYLAAYLLLTTGGKANPTAKDITTLLGSVGVSVEEERVASLIKALEGKSVEELIAEGKEKISSVPTGGVAAPAGAAAGASTEDAKVEAAVEEKEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162X5N7</accession>
    <name>A0A162X5N7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_73365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290675.1">
        <property type="nucleotide sequence ID" value="XM_018442841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162X5N7"/>
    <dbReference type="GeneID" id="29003747"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73365"/>
    <dbReference type="InParanoid" id="A0A162X5N7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="153" mass="17379" checksum="BD69FFAC4C020178" modified="2016-07-06" version="1">MSGIHPISLRPSEGHKDLLFKMTKIKEFMASVRGELTTMHAATRVVFGQYSDGRFHTSAYVSFGGILITAGLTDRIPVVIPPEFRRNHIDKAFDLFIEKDLVSKFDEVPTLNYYCYLYYFGSGKLYDWGQHCPCPCKRGKAEVDTGCLLQQKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162X6K2</accession>
    <name>A0A162X6K2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_159006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290875.1">
        <property type="nucleotide sequence ID" value="XM_018433898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162X6K2"/>
    <dbReference type="FunCoup" id="A0A162X6K2">
        <property type="interactions" value="945"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162X6K2"/>
    <dbReference type="GeneID" id="28994804"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159006"/>
    <dbReference type="InParanoid" id="A0A162X6K2"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16116">
        <property type="entry name" value="Ubl_Smt3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000155">
        <property type="entry name" value="Ubiquitin-like protein SMT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="96" mass="10595" checksum="A2E50DBA524FC1BB" modified="2016-07-06" version="1">MADAGKPEKKEGAAVNEHINLKVVGSDKSEVFFKIKRATPLKKLMDAYLDRQGKAPGSVRFLYDGSRVLPENTPEQLDMDDGDCIDVWVEQLGGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XPD4</accession>
    <name>A0A162XPD4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_4535</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294055.1">
        <property type="nucleotide sequence ID" value="XM_018440187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XPD4"/>
    <dbReference type="STRING" id="763407.A0A162XPD4"/>
    <dbReference type="GeneID" id="29001093"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_4535"/>
    <dbReference type="InParanoid" id="A0A162XPD4"/>
    <dbReference type="OrthoDB" id="5337378at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD76015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="255" mass="29329" checksum="856DAA238A633E52" modified="2016-07-06" version="1" fragment="single">SYQFKFMGRLGSGEYADVWRAQDVTTQKLYAIKQTREQFTSQSDRWLLLAEVENLHAVKGSPHCVELVSAWEQEGYLFIQMELCESGSLAEYISHKDGQIEEDVLWNIIYELAKGLRDIHNAQVAHLDLKPSNILLDETGNLRIGDFGFSLQCSGEPRDIRGEGDRRYMAPDLLKDHFDMPADIYSFGLILLEMVTRTVLPDTGESWEMLRLGDFSDYKMTHVSQALQDLIRRLLTLNEKDRPTAQELLDHDDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y8J9</accession>
    <name>A0A162Y8J9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-galactosidase</fullName>
            <ecNumber evidence="2">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_76954</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2"/>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297035.1">
        <property type="nucleotide sequence ID" value="XM_018443204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y8J9"/>
    <dbReference type="STRING" id="763407.A0A162Y8J9"/>
    <dbReference type="GeneID" id="29004110"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_76954"/>
    <dbReference type="InParanoid" id="A0A162Y8J9"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050985">
        <property type="entry name" value="Alpha-glycosidase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053:SF3">
        <property type="entry name" value="ALPHA-GALACTOSIDASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053">
        <property type="entry name" value="GLYCOSIDASE FAMILY 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02065">
        <property type="entry name" value="Melibiase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD78995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="737" mass="83228" checksum="D3CEC8AE8282A061" modified="2016-07-06" version="1">MSLSLNTFQTTNSRVDVTYKLTGQPEPVQLSGVVVRPGTPFNNGTIVITTHTLPHSTKGIVLAIDIQALKELELVHFEAKYSVDLTEQRMLANGFQSWSQAREMDQNDKIPSIRSSIAWYTQYNLQGDYDFFPHSGEKGQIHSSSYTHFRDIHNVLRFFGSISESLGYTYFKSDYNNNILSVYKDVFGKTIAPNQTLELIRIFIGESNQEGALWDMYGAFFEDKRCLKGNTAQRHVNGWTSWYNYYGDVSEEIVFENVDALVKHKYPINVFQIDDGFQTAIGDWLSINKKFPSGMKSVASKIKGAGFMAGLWLAPYAVGFNSNVAKKHPDWLIQDPITKKPVVAGPNWGGFYALDMYHPQAREYLREVFHVVLEDWGFDMVKLDFLFAAAMIPRLGKSRGEIMWDAMEQIRELVGPDKLILGCGVPLAAAWRKVDYCRIGSDVSPWWEDTKLKLLHVRERVSTANSLVSTLSRWAMSDRMFGNDPDVMILRNKKNKLKPSERYTLCVLNNILGALVFSSDNVGDYGKDEHLLYAATFPKVVAHVESVIEFRPEMFLVHFTVANKGGEPRHYTTISNMTGESQTCYLPPSDDETHLYFATNDSMHMTKPDKREPLFYHPSSRFTLEEHETKTFLHIPPPSPENNGKVTLMGSTSHIVPGAEVELLDLAPDGSVQIKFRKENQRQRKVYICLGNQYFATRAAPSACKVNGVMVPVEIHPISGNGEGRTETEVAVAVVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YHR4</accession>
    <name>A0A162YHR4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CAF1B/HIR1 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_61828</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298815.1">
        <property type="nucleotide sequence ID" value="XM_018440860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YHR4"/>
    <dbReference type="FunCoup" id="A0A162YHR4">
        <property type="interactions" value="567"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162YHR4"/>
    <dbReference type="GeneID" id="29001766"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61828"/>
    <dbReference type="InParanoid" id="A0A162YHR4"/>
    <dbReference type="OrthoDB" id="71227at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045145">
        <property type="entry name" value="PTHR15271"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271:SF4">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="2"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="74"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="133"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="175"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="304"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="500"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD80775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="530" mass="58771" checksum="4893CD2F42D58F46" modified="2016-07-06" version="1">MIAQTLEINWHDTKAVYSTDFSSDGMRFATGGADTSVRIWNIQRRPGTNQVNEHKKSHKSGNALPVVIDFLCELKRHSAPVNVVRFSPTGEYLASAGDDTCIILWRLATNKDSAFGSVHSEYEKETWTVVQMFYGHTKEIYDLSWSPCGQYFMTASIDNTARVWSIAEKTMIHVFSDHTHYVQGVTWDPLGEYVATQSSDRSVAIYKYRKGPLDKPIFGPCFRKHYRQERPKTQKSEGSEELTSSRLYHDENLVSFFRRLWFSPDGALLLTPSGLFKSTPEGTTGTGAGTGAGAGTGSEETVESGADEVRNCAYIYGRNLLQKGPVAYNGNHPKPSTVVRWCSKPYERRSKHYRTTFGLEYRMLYAVATQDTIYIHDTQQTRPICVLSGMHYAPIMDLAWSPDGTILMFASSDGYLSAVVFADGELGELYTAPPAPPPTPLASLAPSPSSILPSPQKQIVTPPAVAQIVKDVEMTEGVRTSNSVQTTIGDLLGITVRTETTERKRTSEVQTAGPKKRRIAPTLISAPRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZAP9</accession>
    <name>A0A162ZAP9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_176076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441010">
        <property type="protein sequence ID" value="OAD65481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283521.1">
        <property type="nucleotide sequence ID" value="XM_018437645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZAP9"/>
    <dbReference type="GeneID" id="28998551"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176076"/>
    <dbReference type="InParanoid" id="A0A162ZAP9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="292" mass="32802" checksum="79C73496A5154291" modified="2016-07-06" version="1">MPTPNRRLAPSLASTDVQLLQALNAMKEEMTAMKDKITLMDTRIGVVITGNATAINGIDVLSALPVSAHVPTSVASTSAALPITESSDTNTVFVRIHSWLYVEPKAKIQANAIKPKELVKQLLYYLEKKFAGTDLRTRDLRKCMYTNFCSRRCQQRELPETRRALNTNSRRSGRETDNYTRHHLAYDAYKADIDLKMGQNCSGLIQKSVMSEGKSDDDMSPPQPRNEIRVARPSWRSDKLNKFITEVDSFVVKQLGANSRQLLKRVYGRTVESTVPIDLDPALPQWALKYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZI09</accession>
    <name>A0A162ZI09_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SigF-like NTF2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_160501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD66911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284951.1">
        <property type="nucleotide sequence ID" value="XM_018434190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZI09"/>
    <dbReference type="GeneID" id="28995096"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160501"/>
    <dbReference type="InParanoid" id="A0A162ZI09"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057514">
        <property type="entry name" value="NTF2_SigF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24840">
        <property type="entry name" value="NTF2_SigF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SigF-like NTF2-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="141" mass="16377" checksum="AAF2CACB57987C13" modified="2016-07-06" version="1">MCTGITADLYSNDTQKQRQVLRQHFSPNASFVSPLLRTSGIKNIGHVFLVWKTLNRDPPTIEKSCSNQHHCVIFMTQHLRPRLFPLLHLALPVIVTLKFRESESGKLKVEHLEEHWTVEGMCICVFIRTCIEYIICLLEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZPE5</accession>
    <name>A0A162ZPE5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ArfGap-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_173236</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286271.1">
        <property type="nucleotide sequence ID" value="XM_018436977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZPE5"/>
    <dbReference type="FunCoup" id="A0A162ZPE5">
        <property type="interactions" value="230"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162ZPE5"/>
    <dbReference type="GeneID" id="28997883"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_173236"/>
    <dbReference type="InParanoid" id="A0A162ZPE5"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000252">
        <property type="entry name" value="ARF GTPase activator (Csx2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF160">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN EFFECTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="349"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="8">
        <location>
            <begin position="546"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="296"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="718"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD68231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="866" mass="98081" checksum="F2B333E03F8A96E2" modified="2016-07-06" version="1">MADLETRPLQTIPGPAFNEDSPQPISTTRTCADDQDLEDGPLFRATIKQLENKTSALKASTKRILKTAVASVEAQQALMDADTNFLDALRDIPSATPPLTEYMDRTWAILYEQRLRLQQSMRDIILDPLQKRYDYEIKTAEYKRRRFEEASKDYYSYLAKYLSIKPETLSKDKKRTEREQKHIARQSAFDLIRFDYYNFLVDLHGGKKEQEMLFNLVRNQQEESSFYQFISSGVIPHKEALDNVATLMEEAAREQDTFYKERSEKRRTMLTRHNQHVKDMLKTEYIKEQAQLKRTSLRTSANVSDVEENPISTDPGLPEPSQSAGSAENRFKGIHDLENQDRNMLWACGRRKEGVLFSTSKPSKGTAFEKGSNVTWHKYWCVLSGGQLHEYSNWKRHVESHIDPIPLRYATVRQACNADRQFCFEIITPYFRRMYQAISQEEMMSWMATIRNAIESLLNGTGSSVNLIKDHLIKEEETNNDQSPKKGHSRSLSKAIRRGLAERSRWSGFSFTSNSNGSAGHGHIAKNSGAVGQYEFSPSPDATVNTKLLTTLREDRSNVLCADCGERNPEWCSLNLGILLCIECSGIHRSLGTHISKVRSLTLDSASYTPDIVELLRSIGNARSNAVWDPKRCLTTNDDDCLTTDEVDELRRPVPGDTRDFKLKYIQQKYVEKAFVYHTHKDLNTLLFDAIDNDDIPAALYAVALGIDLNRSWPFTSARSSSSDEDGSQNSRNSQDSIPLPTIVLSSGNNLCATNTTGRDKIDDPTVRYPLHYALLYGRRTLPSVMTDRNRLFPMAEFLLQNGADAGIIDPETGNTLASIVGLGSIVEDDAIAYLNLKNAARGQPQIFRASMPIIPSHSFIDATYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZV83</accession>
    <name>A0A162ZV83_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_172484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287271.1">
        <property type="nucleotide sequence ID" value="XM_018436811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZV83"/>
    <dbReference type="GeneID" id="28997717"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172484"/>
    <dbReference type="InParanoid" id="A0A162ZV83"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="235" mass="27021" checksum="5CA5DB509340CB44" modified="2016-07-06" version="1">MEVVFLVTILLDHKIVSRFMALQRYKCKSTLKIPAFIEPYLTCPVLKAVLRAVKKNVCKFILPKEHKLTSINFIGNNPSATYVEVTEQVEKPFHYFKVSPRVVHSFIIDECFFKYYSLELKNLRHGPSFNIGHCLRILKNYTDTQRTPLNHLQYPPASSSSSTTSCFNEENKKDMFISEIQGLPLKILYHMYFLKSILSSESIGTQAIDLSKRGIQALDYVSFFTKPNGVQLLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZXA4</accession>
    <name>A0A162ZXA4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_149417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287671.1">
        <property type="nucleotide sequence ID" value="XM_018432271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZXA4"/>
    <dbReference type="STRING" id="763407.A0A162ZXA4"/>
    <dbReference type="GeneID" id="28993177"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149417"/>
    <dbReference type="InParanoid" id="A0A162ZXA4"/>
    <dbReference type="OrthoDB" id="2325329at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="59016" checksum="31EF13169B2EB3D9" modified="2016-07-06" version="1">MNRQHMIWLEQASPTESRLLRLPKELILKIMSYVAVDSQTDYPSSLIELSKTSREIYYLIHHDPWRLLTLWRCAFHVRFDTAALYRRRLDRYIDWKAVMNRRFKALYGCRAYAQTRQTSNLQYLDWEVIWEMLTEHDDRNVWLLHYYDVPVAAADAFTHSDGSNHAIILPILSLLVNYDFKLTDALRSSQNSQSQIVCPSLTRMAYHPETDVMQTTDMATTFSPAQDSSSSAYHLFFATIFAHHPTPYQSIPGCVPIPLFPLSSALFDVEYLRRYERNLFVASLSESRCGWQDRPVIGSVENVYASTGFGSQSHYVTEAHRIEGEWIGYYSFQDEGDNDSDNSSTSTISSQPGDWVDGPIRLSLHIVPLDPHVHSSPQQLSSSYLSSSSSSSSSSLLESSSLYLSSPPYCKTSENTTDSLGFPSNHLRTCPLTRFEGTGIDGNGAFTVSGLIDDSEDGQITWEKSYVESEETWEYSGRFVWPMGLCGRWGDEEYGGPWWIWKAASSDSIALPLPVLKPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163A5K2</accession>
    <name>A0A163A5K2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GOST seven transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_66495</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289261.1">
        <property type="nucleotide sequence ID" value="XM_018441650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163A5K2"/>
    <dbReference type="GeneID" id="29002556"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_66495"/>
    <dbReference type="InParanoid" id="A0A163A5K2"/>
    <dbReference type="OrthoDB" id="29657at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF2">
        <property type="entry name" value="RE59932P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007841593" description="GOST seven transmembrane domain-containing protein" evidence="7">
        <location>
            <begin position="25"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="8">
        <location>
            <begin position="167"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD71221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="435" mass="49473" checksum="8B6B21276E19B170" modified="2016-07-06" version="1">MSVWPLFRIILALIPICVCWQVQADQDIILKHDLRKIVPTAQFGFLSRGQLTLTLQDYKLDNPSAPGPIGFYIRKGEIYGETWEEKADQGCILEKSEITDEIADGISVVESLEEITERWQKTLTVEPSEEGVWKIILVNCKNTGVSLNLEMSMINPGNNHLSAGDTPLFKVYGAVFLCYLCLSIYWLYLIVQKDTTVFRAHWFMLLLVMSMCFNKALQSAKYYYMKIGLLSNGWRIGFYVFAFIKGFLSILIIVLLASGWIFIKPFLSSKDKRVISVLVPLQILANVATAIQSEAAIKSTDWTVWTAILPLADIFACGVVLWTILQTRKHLGAAASADGKELDVLKKYDLWSSFYIVGLVCATLTSIVTVPLRELVRSSCRRACYITIFWVYWVRDSIGPSLNNPYMDLPDQHSIDWRDSREDRGQTMVMNRRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BFE6</accession>
    <name>A0A163BFE6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_73842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299271.1">
        <property type="nucleotide sequence ID" value="XM_018442928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BFE6"/>
    <dbReference type="STRING" id="763407.A0A163BFE6"/>
    <dbReference type="GeneID" id="29003834"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73842"/>
    <dbReference type="InParanoid" id="A0A163BFE6"/>
    <dbReference type="OrthoDB" id="2404451at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="772" mass="88300" checksum="3A98FBB56B6EACF5" modified="2016-07-06" version="1">MESMELNNTISYKCACNFEDSEGEAHIYDSSRISTNTFTKAELMSIHLSQLMLQHRIARAAYRDIVQFINTVIRDHDDIMMVMAKLLMLCSSQSQVSRAMSMMSALVVVDCMALMMTRNLVLTVANRNTRLIPIKLTNIFDGDNYKQLVQQGLFSNPDDIAIGLYTDGFVNQKKDPSIRYTNKYLLQLAILPGPKKPTHLDSFLILIINELRDLKAHGLVVKHNGVELYRSKVYLLLAFGDIPAVADMAHIGSHTSLFGCRFCEIKGKCPTNRRHGMYFDDISAWLRPLEDFKVGNPSKNIYQPSIYTQLSTFSGSSFFALDELHLIARGIGKFVYDLITVTLTKETKFYYTHPDNTLNTTEYPFHIPRADLVTIGNCITSSRKYIFTSFQGSFDNVFAKIDGTLTVDWLDFLLYLVPTLFVPYLPNRAVKTALLSLTLTSELLDEMELYFKHWHSFLYQQVQNNTLSHSVFRPVQHYLVYIPYIIKQRGPLRCYSTRSMERVIGVFSKLIKSKSKGGRNASFLVERFAIHNCTSTAISICDETNLIRPKPYGRESYMDLPNNPSGAQLWEPFHQFVNLNDDLVEGVNGPSMKEALLKYYRRTTGLTGHEFGDSVVVVAAHLWMDSTVYSSCMYRRKKNETSHGNHYVMFTCPYRNNLNVIVHSWLVGTVQFYFQYVYFHGFLHFFAFMEVMKEYDAAGHDSSVPIVKQRSQSTHTLGHQTQLTYAVISVNDICHQVGLVQYPPNGNKFYVIAPYYIFNNNICITKGNLSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163CWW0</accession>
    <name>A0A163CWW0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_70975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441005">
        <property type="protein sequence ID" value="OAD66190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284230.1">
        <property type="nucleotide sequence ID" value="XM_018442378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163CWW0"/>
    <dbReference type="STRING" id="763407.A0A163CWW0"/>
    <dbReference type="GeneID" id="29003284"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70975"/>
    <dbReference type="InParanoid" id="A0A163CWW0"/>
    <dbReference type="OrthoDB" id="2202553at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="24099" checksum="DEE9DA8AC8D62E8E" modified="2016-07-06" version="1">MTKEHKNHVPDHKSEIRTIPLPAEAIKIIEQQLRSGSSCRNTRISTLHQIESWVWALESQIMKRGTLCSIYEKIQMKALLYIFVSNKKDSLAVWINVKLSVNNYCIFTATLSPLNDNKDLFAFGFQSPLQVGIMRNLCKKFLDHVLSCNSPLCNQKGFPVAYMITNDKSAVPIIQWLSHLLHNSRFRPLHITINCYISEHCKSNPESRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DJI5</accession>
    <name>A0A163DJI5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_69970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289730.1">
        <property type="nucleotide sequence ID" value="XM_018442191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DJI5"/>
    <dbReference type="STRING" id="763407.A0A163DJI5"/>
    <dbReference type="GeneID" id="29003097"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_69970"/>
    <dbReference type="InParanoid" id="A0A163DJI5"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051049">
        <property type="entry name" value="Dienelactone_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46623:SF6">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46623">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="240" mass="26453" checksum="9F7BB4E1A217B077" modified="2016-07-06" version="1">MSFSFPVLHFEPQGPKQIPDAAIIVLQEWWGVNEQIKRHAQHIANNSGAHVVVPDLYKGKIGLTAEEASHLMSHLDFEAAIGELLQLVTHLRSTNKTRIGAIGFCMGGALSLALANQATLLGAPIQVAITFYGTTSGKLDVTHISKDTAVQGHFGGQDNQIGFSDPPSARQLELDVANTKDVHIYTYPDQGHGFLNVDDWSISVRKDMDMVAKDSDPVKEEKPIRDLAWSRVFEFFDKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DMF1</accession>
    <name>A0A163DMF1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_88880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290370.1">
        <property type="nucleotide sequence ID" value="XM_018443701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DMF1"/>
    <dbReference type="STRING" id="763407.A0A163DMF1"/>
    <dbReference type="GeneID" id="29004606"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_88880"/>
    <dbReference type="InParanoid" id="A0A163DMF1"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF24">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="8">
        <location>
            <begin position="198"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD72330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="441" mass="48234" checksum="80A1825216F0021A" modified="2016-07-06" version="1" fragment="single">AIREAFELSPTKFEALVKGFQQEYNTGLTTSSAEIATMIPSYVTRMPNGKEKGTFLALDLGGSTLRVSAVNLLGEGEVKVTEVRRAIAVADPLRTGTSDAFFDWIVEAVDELLSKINTHTPLSMGVCWSFPIDQTGISTGTILRMGKGFDIKGIEGKDLNILFQEAFKRKAINVTVTAILNDTVGTLVAHAYTHPQARIGFIYGTGVNAAYPEKVSRIQKLKNHNMGPDVEMLINTEIDIFGNESYLPLNRFDLALDATHSQPKFQLYEKMMSGAYLGELTRLASLELIASGDLFKGNIPNQFKNPWDFSSASVSILESNAVTRWEDQKVAVETLLTFENEYQLSATDLSLLIQVAHLISDRAARLAGGAMVSLLEQQKINLSETDPIVIGVNGSVYELYPQMPERIQQSLIDWFGPTISSRLQISLATEGGSIGGALIAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DZ89</accession>
    <name>A0A163DZ89_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_167764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292390.1">
        <property type="nucleotide sequence ID" value="XM_018435718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DZ89"/>
    <dbReference type="STRING" id="763407.A0A163DZ89"/>
    <dbReference type="GeneID" id="28996624"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167764"/>
    <dbReference type="InParanoid" id="A0A163DZ89"/>
    <dbReference type="OrthoDB" id="3248986at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD74350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="766" mass="88523" checksum="7053D556580E761F" modified="2016-07-06" version="1">MSNNQKKDSYVICKCPDCTKLDSCGKKQKRQNAQRHYEKHIVPVAKDDAMDVPEEHFDDMEVDSIDSDNDNDYDYKNEGEGEYEDKNEEQNIEFDQEVDLPLSQEESIFTVKDTITGAFVVDGDEIEEGDTSFDFEQEENFDETSGTSIVESVRPSSFDNMPLYIRFVAVFIVIFHLIFLVESGESILIEFCNTLLSLCDMSGALPLTINSLKHKTGFNMATDRMTVYIACSQCHSIYPPETSQRVCTFKKFSQSAICNNNLFKVSTGNRSLPAMIYPFNSLKYALQQKFSKPDFVSKINLWRKKENSTRWSELHRLSYFDPVHFTVIDPMHNLYLGTAKRMIQIWRECNYINEKNQLTMQELANGIVVPCGYARITKKIADGFSFMKADKWKSWCVIYSPFVLKHVLPAKNLENWILFVDACRLLTKPSINDKEIDEAHSKLQLFCTRFQTLYGKSAVTPNMHLHLHLGECVHDFGPIYAFWLFSFKRYNGLLKNIKTNQKGGFESTMMKRFLERTYIGSFIQSFVNHLPQFAIDFLHRISNSQDQLAALHPSSTASTFSLSDFVEYSLNPRHSALGCEPLPPSVFPIKLNQRITMCKGHYECLLEFYRHAYGSHDLFGHYSNCESNQIFVNNRIEKMKRISLLGQEYSSGSYFRAYYLENNSEDKAAFPGRILYLFQHLITINETVITHTFAFVEWYSSYSSGSYQPMLNEGIELWNEPSSVLNYECIIPVHRLYSPIAIAKYRFTITSEFKRLVIPLPQKIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EH65</accession>
    <name>A0A163EH65_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_157599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296660.1">
        <property type="nucleotide sequence ID" value="XM_018433649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EH65"/>
    <dbReference type="GeneID" id="28994555"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157599"/>
    <dbReference type="InParanoid" id="A0A163EH65"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="76" mass="9036" checksum="9D453CFC64FF14C9" modified="2016-07-06" version="1">MLLLLLLLVLLLLLLLMMMLLLVLIMLLIMLIMLLMLELLLDLLMNLLLMLIMVLMLLTLMLLWLLLLLLLLWLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167J3P0</accession>
    <name>A0A167J3P0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_184184</name>
        <name evidence="1" type="ORF">PHYBLDRAFT_184230</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">NRRL 1555</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441040">
        <property type="protein sequence ID" value="OAD65057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV441011">
        <property type="protein sequence ID" value="OAD65272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283097.1">
        <property type="nucleotide sequence ID" value="XM_018438904.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283312.1">
        <property type="nucleotide sequence ID" value="XM_018438898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167J3P0"/>
    <dbReference type="GeneID" id="28999804"/>
    <dbReference type="GeneID" id="28999810"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_184184"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_184230"/>
    <dbReference type="OrthoDB" id="2417874at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="26577" checksum="753344486D9FBE10" modified="2016-07-06" version="1">MTFVLTLLLDQEKAYDRVYPGYLCLVMARTRFPTMLVDSGLRQGDPLSPLLVNSAFKPLLRSILASLSIRNFQFLIPPSLSSSCPSLSLSLLRFLAYSDFYPDWGTVLDVADIHSLHDRHSTTKISYLGFSLGSYISQIEAFGAALLVQLGDRCTLLSQRCLSVRGKGIVTNSLFLSSVFHVLYATPAPLSFFGAIRTNICSLLRLGFGSSGWPFLCLPRKYGGLDLLDFDYQQRALRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JB03</accession>
    <name>A0A167JB03_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_70747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441009">
        <property type="protein sequence ID" value="OAD65627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283667.1">
        <property type="nucleotide sequence ID" value="XM_018442328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JB03"/>
    <dbReference type="GeneID" id="29003234"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70747"/>
    <dbReference type="InParanoid" id="A0A167JB03"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="176" mass="20274" checksum="1D2A11A5C6B47F3E" modified="2016-07-06" version="1">MYFCHLRNKNSIKSNYYSLLIEEGILNTSTKKIKNADNLSVAHCEFFENFLVQQGDPTFIIGWPPMEIAHKPTFENTRIEDGSDWAYALVNWSDESRLTVNGIDERARATRRVDEIYSKKSHRGNQVERGALERSVNNESASIRDVCDLKVSVQRERGRIYFDLTSTLTGSMEQQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JI01</accession>
    <name>A0A167JI01_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_152822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441006">
        <property type="protein sequence ID" value="OAD66016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284056.1">
        <property type="nucleotide sequence ID" value="XM_018433004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JI01"/>
    <dbReference type="GeneID" id="28993910"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152822"/>
    <dbReference type="InParanoid" id="A0A167JI01"/>
    <dbReference type="OrthoDB" id="2283549at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="18117" checksum="E22EAB95ED7BB9A7" modified="2016-07-06" version="1">MLFGMTISPGKLGKVASAIYDKGAASLNIFGLIDGTMHEISKPSQGNKVQKAFNNGCKHLHALKYQSIVTPDGITSNFLGPYVDSRHEARVEEYLDIVPDAELPFALYGDPDYMISKCLYSPFEGVSLSVFNNMIHCTGRNRSPTSSYFGLDPPTLEEYIWINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JLE7</accession>
    <name>A0A167JLE7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_175303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441004">
        <property type="protein sequence ID" value="OAD66247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284287.1">
        <property type="nucleotide sequence ID" value="XM_018437462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JLE7"/>
    <dbReference type="GeneID" id="28998368"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175303"/>
    <dbReference type="InParanoid" id="A0A167JLE7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="116" mass="13117" checksum="DE22B5D0D918021F" modified="2016-07-06" version="1">MIDPFEKLQCPFGHVVYTPQLSEEQTPQPNTGSLLLMNLAKSDSTNWIPDRFIPCQQKDRLPPGNVVTLKLATLNYCKTESVKDKGLIKKYKSHSLFTNPLNSGSKEQEDLKPKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JPN0</accession>
    <name>A0A167JPN0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_156679</name>
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    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_018433508.1"/>
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    <dbReference type="FunCoup" id="A0A167JPN0">
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    <dbReference type="STRING" id="763407.A0A167JPN0"/>
    <dbReference type="GeneID" id="28994414"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_156679"/>
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    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
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        <property type="entry name" value="CTLH_C"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="1">
        <location>
            <begin position="63"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="236" mass="27103" checksum="8BD490B2EF20D4CC" modified="2016-07-06" version="1">MNPTATKRFVSRSEWEQRLSKVKVNKQDLNQLVMNYLVIEGYKDAAEQFSAESGLSPAVDLESIQERMEIRHAIQSGDVDTAIDLVNDLNPEILDTNPQLFFRLQQQRLIELIRKGDFGAALEFAAEEMAPRGEEHPEFLEELERTMALFAFQDINTSPVKDLLHSGHRQKTASELNTAILDSQSREKEPKLPNLLKMLVWSQVQLDERLLYPRIEDFLKADLVTPEEELVKSTDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JU64</accession>
    <name>A0A167JU64_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal recognition particle, SRP19 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_189249</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="OAD66717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018439628.1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="763407.A0A167JU64"/>
    <dbReference type="GeneID" id="29000534"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_189249"/>
    <dbReference type="InParanoid" id="A0A167JU64"/>
    <dbReference type="OrthoDB" id="2190947at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006617">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="entry name" value="Signal recognition particle, SRP19-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="226"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD66717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="28176" checksum="16404C8B73A1789E" modified="2016-07-06" version="1">MSMLKKLKETQKNSVFLDDDDFDIDNMDFPLPTDQNDPMGGLQDLMKKMSAGGENRPQASSSKSNTNISVATTPQGVKTMDPSEYKDWVCVYPVYIDADKSVTEGRKISKSKAVKNPHAYHMALAVQSMGLSVVYEGKKHPRDWANPGRVRVQLKNKNNFFMNPNCTTRKQLFKTIADRLPTIQKESKLPGNILSPLATLAQVEAIADEHRKAQGLPTLAEMNASNAAMMPPPDLPGPSTPTKQKKQKVKYVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K4P1</accession>
    <name>A0A167K4P1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
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            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
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            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
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                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018437227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K4P1"/>
    <dbReference type="STRING" id="763407.A0A167K4P1"/>
    <dbReference type="GeneID" id="28998133"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174316"/>
    <dbReference type="InParanoid" id="A0A167K4P1"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007889162" evidence="4">
        <location>
            <begin position="22"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD67277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="886" mass="97742" checksum="13C48D689B5112A4" modified="2016-07-06" version="1">MNILLLSFVCVVIYSIGHVNGSYFVPQKLLGEMDQRYGSATFIRNKTVYNYGGNTYADQLSNGMSSTSLSSIGNVVYEELPTSPTDPHCSYPSTVYLPGNDTVLLFCGELSDDSDSTILTIWSYNFDTQNPTWTEIAPIIDQGLLTVEARFNAVLGSNGKVYIYFNYLTTTANKTNEFISFDPTTRHITDLSKNIPLHLLYTSTVALPNGLIVFSAGKTKTDASTAEFMPANQVYVYNVNDNTWRNQLVSGYAFLPRNYPNSALGSDNQTIFLFGGISPHLDGVDAMYNDLLLLNTTTWSWSLFEAGGYPPAPRLYASMGFIQDDILSISFGILTPNPRNDVNFLRYSADEKTPSYWMRDWEEYQNGQTPVVVEKKGLKPGAIAGIAIGSLAALALMSASGEPIWAEISRIVFQCIGYLLLAAYLVYIIMDVVNSPKAIITLRNSALTLKTPDIRFCFDGWNNSLSVNEYLRPHMRCSTDEGYDCTQHITSLNMSIHKPAFSEHMGEITCFLYAAPSKFVLTDPTRRIGNGSSLDFSFYGDPTASGAIHAVFFPPGMDPNIILYNINTTDIDPIITPEQMDDWVVADLGDRYAENVYTINPNSTTTLGYELQSYQHLTDDGWNNVGFSPNVEKIPQISTTFRSGTMSKGTRSLAYIISTLKVFPNEYVDVILQEKKTSTLLDALGSAGGVLSLIMGVQLWLFGFRPQSPWGVVHRWSIGRMSHSIKESLRSGFDPTHKSIPFVDPIGQPILSSNSYYNSPHIATGGLSGATTAASAGGGVVATSSGSGDICATGYSDIEGKDTAQLLTEPGTQIPGQLQRLSQVEERMQLMEQMLKAYYIDTEIFKQFSQSVKTSQPDLSRLDVVESIPITESGEMRQRLWGRDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K940</accession>
    <name>A0A167K940_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_69379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285550.1">
        <property type="nucleotide sequence ID" value="XM_018442087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K940"/>
    <dbReference type="STRING" id="763407.A0A167K940"/>
    <dbReference type="GeneID" id="29002993"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_69379"/>
    <dbReference type="InParanoid" id="A0A167K940"/>
    <dbReference type="OrthoDB" id="2405215at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD67510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="474" mass="53528" checksum="A14CCEE9A8C90F8A" modified="2016-07-06" version="1">MSLPGQEVYWRLCDKDGTCYCDWRLFLGDCVIEDRIHKILLVGAIFAIIVSVIAAILLFYRMRYKKQRIWIVSERTGFIQPRPIDSVLVMAILTNSLRAIQTFLVLTNTYPNVIFRSFIHEFPWQFAVSALSCYFFGISHTIADSSTTLSNEWFRSPLLIDKFCTFVFIIPFITNNIFSICSGIYAHRGEIDVAYIFTRALHLTWGIYCFCIFVILFSSGYLLLRVLKRHRATRIRNGSDISVIDTGIIKVKIIVTAGGLATVIFTFFSFMYGIFRNTITMNPVLSTGTCVIWMIDVPLVTLLIEIAILLTPKITVNLGLSDHSSNEDNMSYPRRGSRYSHRARSSSLPQNRQHPKQGLQNKLGSAQKRDSKNEYVFAMDVISSNLITNSRTFEIEGTGPFNRPLSAPTSPGSPTSPGTPGTSTRPQYNFQSKPNNISTDSIKISTVLSPPPYHSNKEPKKRSVDITRSTNDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K9R4</accession>
    <name>A0A167K9R4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_189030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type 2 lipid phosphate phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285597.1">
        <property type="nucleotide sequence ID" value="XM_018439602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K9R4"/>
    <dbReference type="FunCoup" id="A0A167K9R4">
        <property type="interactions" value="367"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167K9R4"/>
    <dbReference type="GeneID" id="29000508"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_189030"/>
    <dbReference type="InParanoid" id="A0A167K9R4"/>
    <dbReference type="OrthoDB" id="301434at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03388">
        <property type="entry name" value="PAP2_SPPase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF28">
        <property type="entry name" value="DIHYDROSPHINGOSINE 1-PHOSPHATE PHOSPHATASE LCB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="9">
        <location>
            <begin position="91"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD67557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="453" mass="50428" checksum="43E62D0DE00D58D1" modified="2016-07-06" version="1">MAKTSKSIDSVDAGTLDGKLYDRALDPLRAKMRRALLPLVRAETPVLAAIQKRIRTPWWDAYFLWTANLGTHTFFMIFLPIIIWFANAELGRGVACLTAAGVFWSGFIKDFMCLPRPLSPPVHRLSMSSSVALEYGFPSTHATNSVSVGLYLFAVSCDTFAPESTARMVCVASCAVYVASVVLGRLYCGMHSLTDVVGGTILAYALYWTQWTFRAEFDSLFTDDGYWVFLTIPLFLSLVGIHPDPLERCPCFEDSVCFMGVLIGLFPGSWLCQHTDICVMSLTSTATQQTGLKAGLIVLLKMVLGVSVLFVWRMACKKACYVILPPIYRAFNLPHRKFEIGARYYKSLKSESIHPIPSVLDLRGLTSSMAESDHVGMQSPIDLHERRVAEAKQCHNRKGRELDEKVPEEDISDDEPLRYDIDIVTKLIVYAGIGFLAVYPVPLLFQLLFGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KBA6</accession>
    <name>A0A167KBA6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA methyltransferase 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_173996</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285709.1">
        <property type="nucleotide sequence ID" value="XM_018437167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KBA6"/>
    <dbReference type="FunCoup" id="A0A167KBA6">
        <property type="interactions" value="238"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167KBA6"/>
    <dbReference type="GeneID" id="28998073"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_173996"/>
    <dbReference type="InParanoid" id="A0A167KBA6"/>
    <dbReference type="OrthoDB" id="270651at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18105">
        <property type="entry name" value="SpoU-like_MRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047182">
        <property type="entry name" value="MRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047261">
        <property type="entry name" value="MRM1_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103:SF1">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="RNA 2-O ribose methyltransferase substrate binding" evidence="10">
        <location>
            <begin position="39"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD67669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="363" mass="39682" checksum="4225AABB75829A12" modified="2016-07-06" version="1">MFLARRLIVKSSVLYSQPSLVCLRKYQAAAGPDEPVNDFVYGYTSVLAALEAKKRQRLKKVFLQHDALNPYTKKKDESFLQKIRDECIARSIPTETVDKGTLNNLTGNRPHQGIVLKATQRYTEGITGLNSLEKDGSYEATPVATRRNKTPIAFTAPKDRQPFWIALDEVQDPQNLGSILRTAHFFGVDGVLMCSKNSAPLSPTVSKVSAGAMEVMNIYSTNNLGKFLKASSDNGWHIVGAVGDPSIAATKSTNTTATATTDTTTTTTVQEPRPQQQYNQTYYDICTLKKTLNDPSSETGQKPMVLVFGNEGNGLRTMIKASCHSFVTIPRQASHLPSFKGEVDSLNVGVAVGVLISSLLLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KBM4</accession>
    <name>A0A167KBM4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_151220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285737.1">
        <property type="nucleotide sequence ID" value="XM_018432629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KBM4"/>
    <dbReference type="GeneID" id="28993535"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151220"/>
    <dbReference type="InParanoid" id="A0A167KBM4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="86" mass="10037" checksum="6F3E50DD7952E63F" modified="2016-07-06" version="1">MDSDMDYMSSCHGLLHYFNFLASIMDVVDGISIHKPHWRLIDIKKSSRHRLFRHSMKDVDDLNCVLCGKLEGDEHLFWACALKKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KCT6</accession>
    <name>A0A167KCT6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_72196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285819.1">
        <property type="nucleotide sequence ID" value="XM_018442614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KCT6"/>
    <dbReference type="GeneID" id="29003520"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_72196"/>
    <dbReference type="InParanoid" id="A0A167KCT6"/>
    <dbReference type="OrthoDB" id="2431110at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="161" mass="19017" checksum="B6D892061E41AA6B" modified="2016-07-06" version="1" fragment="single">MHNLYLGTAKQMIQIWRECNYINEKNQLTMQELANGIVVPCGYARITKKIANGFSFMKADKWKLWCIIYSPFVLKHVLPAKNLENWILFDDACRLLTKPSINDKEIDEAHSKLQLFCTRFQTLYGKSAVTPNMHLHLHLGKCIHDFRPIYAFWLFSFERYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KDI1</accession>
    <name>A0A167KDI1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_188869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285877.1">
        <property type="nucleotide sequence ID" value="XM_018439573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KDI1"/>
    <dbReference type="STRING" id="763407.A0A167KDI1"/>
    <dbReference type="GeneID" id="29000479"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_188869"/>
    <dbReference type="InParanoid" id="A0A167KDI1"/>
    <dbReference type="OrthoDB" id="5579281at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902657">
        <property type="term" value="P:protein localization to prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040345">
        <property type="entry name" value="Mug56/Spo71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039486">
        <property type="entry name" value="Mug56/Spo71_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057379">
        <property type="entry name" value="PH_SPO71"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28076:SF1">
        <property type="entry name" value="PROSPORE MEMBRANE ADAPTER PROTEIN SPO71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28076">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15404">
        <property type="entry name" value="PH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23207">
        <property type="entry name" value="PH_SPO71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="774"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD67837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="941" mass="107568" checksum="C870D9C4DE6C58D6" modified="2016-07-06" version="1">MVSYEQITLLHKDWLVSVGNVSKSQANLAVVRLPLYILAVWCSQASHELYPIRSQFINSSIQCRSEHEIASNLENPVESTNLDSSSASPTSQLSHAGSPSSSHPTSSNDQTRHVNQTPSSSHDSFFTAYSEAVSTFEKHSEIENSDDEIDFDILRNNPEPLNSPHASSISASSALSIPTIRPPPTSQIALVDEEMEPSIPEPLSQERLSVQPQLKKKRSLVDRLTIAPKKLLWHKAGGVFVPTMPEVPANRNPAQFPGQPIKHGVMLCMKTVSYKNGSEPTRYRATKEARLGMFKGNWRQLETVLTSDGITTYSNSLLHWPKRYEEYKIGFSDKDRPPKLRLSLVSPLDYTFCLRYESKSDGEYSSVTFRARTLTLCQEWYMAIYCLLPEVCKTACPLFCEVYVPEIDIRIHLPLILDENRLVPCYDITAENVKDVLLAMIHEDQAWANSINEQLGGGMFGLCWTRKDRAEWIYWKNNVDNDSRRDVVICPQSIEKTHQLELRRVEHTPHDVILAGDMSLKEPQPIEGFLTRLTDYYGREIKNRQLIRRRYYISSFDQYLFYTKPNKVTVADPKCFVNDREVVLTKKPCPYIGLISPYGELGSDLEANERKRRMQLMDLASGLIDLTEVAYVRRAFSADFTQSGISESGSFGATSTTPVLHRIQSDQPIYPPKRRDDDIGYLEIVMNSGVIIKYEAFSNETCDAWVHQLAKLIVYWKALKEAERDVHARNNFYNGLNHHMQLALEENPVQLPKDKNCLVDTRIWSLCAFEQCRDVMKTGIMYFQPHSRGTFTQKLFILTTSGTLLYYNIFKRSSMVSQPLITASHVKKGSFDIANCFVFSGDLSMDMDRPPNRPPRMFSDGLVTEDSDTDCIFTLWKPLLRRSFSPQRKRISVYTSDFRPNPDGETWTFLAKSRQEREEWVWAINQIIEKTLRSQIAAKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KHY0</accession>
    <name>A0A167KHY0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_79404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286185.1">
        <property type="nucleotide sequence ID" value="XM_018443461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KHY0"/>
    <dbReference type="STRING" id="763407.A0A167KHY0"/>
    <dbReference type="GeneID" id="29004366"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_79404"/>
    <dbReference type="InParanoid" id="A0A167KHY0"/>
    <dbReference type="OrthoDB" id="3239304at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23446" checksum="53A90F5CD58127B9" modified="2016-07-06" version="1">MGSSKSCCCCIPLRAGVMVIAIVSSAFYISSLVYLLIRRSDMFAKHPDSLNFLTPIFWTSVAVVSVYSISSILGVFGSISQNRAMTAVFRVLYWIMAILILVVSVAGWVLLLVNRDSWQDECANYVSKPDSDIYSIVKVPSGSEVATVLQNACSNDLKTILIVSGIAVVMGNIIQIYFASVVSSYASRLKRGNKHIPLRNLDDFPDNSHKNMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KJL7</accession>
    <name>A0A167KJL7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Cysteine proteinase 1, mitochondrial</fullName>
            <ecNumber evidence="2 9">3.4.22.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_183205</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.</text>
    </comment>
    <comment type="function">
        <text evidence="7">The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.</text>
            <dbReference type="EC" id="3.4.22.40"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. Binds to nucleic acids. Binds single-stranded DNA and RNA with higher affinity than double-stranded DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.40" evidence="2 9"/>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286286.1">
        <property type="nucleotide sequence ID" value="XM_018438734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KJL7"/>
    <dbReference type="STRING" id="763407.A0A167KJL7"/>
    <dbReference type="GeneID" id="28999640"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_183205"/>
    <dbReference type="InParanoid" id="A0A167KJL7"/>
    <dbReference type="OrthoDB" id="2666448at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070005">
        <property type="term" value="F:cysteine-type aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043418">
        <property type="term" value="P:homocysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00585">
        <property type="entry name" value="Peptidase_C1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004134">
        <property type="entry name" value="Peptidase_C1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363:SF2">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03051">
        <property type="entry name" value="Peptidase_C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005700">
        <property type="entry name" value="PepC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0788">Thiol protease</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005700-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD68246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="490" mass="55630" checksum="2ED80476DF969846" modified="2016-07-06" version="1">MGSQPSKEQQNEYDEKRASASTESPSPSSSSLADKMANLNLGSSTLGSESLTSRSLEKYSNHFWSDRKNQFALNAVVNNDYRDVIYNHRAVLKDNHVFNVKVPAEAQITNQKSSGRCWLFAGTNVMRLAVIKKYKLNDDFELSQNFLFFYDKLEKANWFLEQMIELAETDIDDRVVQYLLQTPINDGGQWDMLVNIVQKYGVVPKSVYPETFASSESARLNWLVKVKLREYAVQIREALQTGVSASIIRVIKEEMMQDIYRILVIFLGEPPAKFDWEINDKEGKVLSLSGLTPKSYFKEVVSYPIGETMSLINDPRNTYARLYTVARLGNVVGGQPIRYVNTTIRNMKRLAAEVLKSGKPVWFGCDVGQFSSSKYATMDDKIFDYSTAFNVSFGMTKEQRLLYGESMMTHAMVFTGVHFDKDGQPIRWRVENSWGPATGDKGYWIMTDTWFSEFVYQLVLEKSAVSKDLVAILDTEPSVLPAYDPMGALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KKT5</accession>
    <name>A0A167KKT5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_173321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286359.1">
        <property type="nucleotide sequence ID" value="XM_018437004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KKT5"/>
    <dbReference type="STRING" id="763407.A0A167KKT5"/>
    <dbReference type="GeneID" id="28997910"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_173321"/>
    <dbReference type="InParanoid" id="A0A167KKT5"/>
    <dbReference type="OrthoDB" id="2439524at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="62"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="220"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD68319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="282" mass="33007" checksum="84DD9917C2DE7387" modified="2016-07-06" version="1">MHGKSSFAPKDTKGINLRVEEIKKKLRMYERKDIFNFDKTGLFYKQPPISTISTAAISGPEHSFQYYHNDKSWIACVIFRDICKIINHQVRNLGRKILVLLDNAACHNTHDNYTNVKFLYLPSNTTLYLQPLDTSFIQNFKVKYQHYQYTLATQRYISNMIINPDDYFKLSQLEVMNFTSIPPIISETVNIPIEDITIISGCQHLIENNIEVVETPEESLYTLEDDILDEENKNEENEDEKNEYSLKKKRKIIKELVVNLIHLVVPNSQPYQHIMMKTLVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KN13</accession>
    <name>A0A167KN13_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_173457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286505.1">
        <property type="nucleotide sequence ID" value="XM_018437037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KN13"/>
    <dbReference type="STRING" id="763407.A0A167KN13"/>
    <dbReference type="GeneID" id="28997943"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_173457"/>
    <dbReference type="InParanoid" id="A0A167KN13"/>
    <dbReference type="OrthoDB" id="2289822at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="457" mass="52043" checksum="88F8F3CC92D525F4" modified="2016-07-06" version="1">MYFDDISARLRPLEDFKSKNIYQLSIYTQLSTFSGSLFFGLDELHLIARGIGKLVYDLITITLTKKTKFYYTHPDNTLNITEHPFHIPRADLVTIGNCITSSRKYIPTSFQGSFDNVFAKINGTHAVDWLDFLLYLVPTLVMPYLLNRAVKTALLSLVKGCTLALQWTLTSELLDEMESYFKHGHSFLYQQVQNNTLSHSVFRPVQHYLVHIPYIIKQQGPLRCYSTCSMERVIGVFSKLINSKSKGDQNASFLVEQFAIHNYTSMAISICDEINLIWPKPYGRESYMDLPNDPSGAQLWEPFHQFVNLNDDSVEGVGSPSVKEALLKYYRRTTGLTGHKFGDSVVVVAACLNNCNFYFQHVDFHGFSHFLAFVEVMKEHDAAGHDSSVPIVKQRSQSTRTLGHQTQPTYAVVSVNNICHQVGLVQYPPNGNQFYVIAPYYIFNNNMRITKGNFSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KRF8</accession>
    <name>A0A167KRF8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_150297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286746.1">
        <property type="nucleotide sequence ID" value="XM_018432445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KRF8"/>
    <dbReference type="STRING" id="763407.A0A167KRF8"/>
    <dbReference type="GeneID" id="28993351"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150297"/>
    <dbReference type="InParanoid" id="A0A167KRF8"/>
    <dbReference type="OrthoDB" id="2285175at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="177" mass="20617" checksum="923BD0D20D5CE2CF" modified="2016-07-06" version="1">MKTKIAKLWRSWAIPPDLNCSSRIKLSKHFESFRQEKFAHFRLTNTKILIQACRPLLEVDPVLFLPATRIERGRLVRWRMGWLPGKPKECACGFDHTSRRHLQFCITIPSQLFSQLPASPTDEDNIIDFAISALPISFTHPSPLYWKALLTILWHIDMLCNPNGNYTHETDHSSLWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L0Y7</accession>
    <name>A0A167L0Y7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_149732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287377.1">
        <property type="nucleotide sequence ID" value="XM_018432326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L0Y7"/>
    <dbReference type="GeneID" id="28993232"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149732"/>
    <dbReference type="InParanoid" id="A0A167L0Y7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD69337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="491" mass="56671" checksum="43FFCAC11D619078" modified="2016-07-06" version="1">MSKTESIFTDTNDHQYFKPYPHCLKSNGRDGHSARDGHSARNGRSARNARSSRSGCNNCNNCNSHNRRNCLRILHNSASNKQYRKLMIVMVINGRIRCICRIRPDGRNGLNCLIIIHLGRKVVIVVIFVIVFIVLIVVTVVVVVTVYGRNRRNRRNRRNRRSGRNCCSGLIVVIVVFVIIVAIVAIVVIVVIVVIVVVVVIVAVKFNGRNGRYRRYRRKRRKRRNRRYRRNNCNGRNGRNGRNNPNVRFNRNRRNRRSLGSRCSRGNNIRPFHCSYGEVLHVMFMYQCPVSRFQSRFAFEHQYFLSSLRLSVSLAIEFAQGEKKPKGILSWTLLFEMEKLQCLNRSGLLAALDCELVNCFSRHTNKSVAFTPWKRLLEGAIPSPCLEFLSLFSSKAKLIYKKPTDHKYRQGKTLDIGSPDFVLWDMSRLSQKELDMRDEPEAKLRCLSKCYAVHLGVSDTCPEQFGIKAFHRYFAVMVNLMPCRVGRNEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L161</accession>
    <name>A0A167L161_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Survival Motor Neuron Gemin2-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_172607</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMN family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287396.1">
        <property type="nucleotide sequence ID" value="XM_018436835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L161"/>
    <dbReference type="STRING" id="763407.A0A167L161"/>
    <dbReference type="GeneID" id="28997741"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172607"/>
    <dbReference type="InParanoid" id="A0A167L161"/>
    <dbReference type="OrthoDB" id="197400at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22852">
        <property type="entry name" value="SMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040424">
        <property type="entry name" value="Smn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047313">
        <property type="entry name" value="SMN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049481">
        <property type="entry name" value="SMN_G2-BD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267:SF1">
        <property type="entry name" value="SURVIVAL MOTOR NEURON PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267">
        <property type="entry name" value="SURVIVAL MOTOR NEURON-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20636">
        <property type="entry name" value="SMN_G2-BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20635">
        <property type="entry name" value="SMN_YG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival Motor Neuron Gemin2-binding" evidence="7">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD69356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="154" mass="17620" checksum="8FB536E17269E541" modified="2016-07-06" version="1">MKKGSKANQVSREKQDAHLPAIGETIFTIGDGNREDVWDDTELIAHWDKEVDKYRAMFTKEKDSPPPFGNSKTKEKRQKKIIKPIEKKKIKKRVNPETSSNRMPPNILKGVPTTPMSTPPCVAAHSEQNKDEDLTSLLMSWYYCGYYTGLYQVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L4Y8</accession>
    <name>A0A167L4Y8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP pyrophosphate-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHYBLDRAFT_95948</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287645.1">
        <property type="nucleotide sequence ID" value="XM_018443933.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A167L4Y8">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167L4Y8"/>
    <dbReference type="GeneID" id="29004838"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_95948"/>
    <dbReference type="InParanoid" id="A0A167L4Y8"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17214">
        <property type="entry name" value="RA_CYR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055071">
        <property type="entry name" value="RA_PHLPP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23010">
        <property type="entry name" value="RA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ras-associating" evidence="15">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="16">
        <location>
            <begin position="760"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="14">
        <location>
            <begin position="1082"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="502"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1023"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1028"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAD69605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1315" mass="147619" checksum="AB651F2BF048B143" modified="2016-07-06" version="1" fragment="single">CIRVFRPDKTFATLQVPLNTTTAEFMHRLAGKFFLQDLSKYSLVLRQHTRERALQPNEKPLMIQKRLLEQMGYTEQDKLEDVGREDNSYLLRYTFGSNLIHTIEEEGPPERYREVNFEGRNISTIPIFLYKYSSRISSLDLSKNLQIEIPLDFAESCHNIKKLILANNEHGTIPASVRTMHTLEHLNVSGNQLRDLNHIRLEELQRLTTFKAINNQFSSLPKAFSILNHLTILFISNNCLSEFPDVICEITSLAYLDISFNKMASLPDNIGDLVNLVGLFAIGNHFEGSLPASFAKMEKLVEIDIRQNRITELDILYLLPKLEVLLVDYNAVSVVSSQFTNLKKLSMFKNHLTQFNLESFGITTMLTELNLSCCKLSSLPSDLFFGMPCLETISLDSNTLNTLPASIGSLQKLIKLSVQNNVLDSLPAEISKLSLLRILDAQKNNLKVLPNEIWMCASLQILNCSSNLLESFPEPYTTPSIALRLPSAESYVNPTANNTAIDTYTGHGSSTPVPPGEYPSHAYPHLDDDSSVSSPNSALNAPPDFNPPSFFASPRNHPPPLSLSLRHLFLGDNRLTDDVWSPLSLFLELRTLNLSFNYLYDIPPEGLCHQHLYELYLSGNYLASLPADDIEKLTFLRVLALNGNKLQTLPAEIGKLRKLLVLDVGNNVLKYNISNWPYDWNWNWNLSLKYLNLSGNKRLEIKKNVPDQHSPKEKNMSDFSALKRLCVLGLMDITILGVSVPDDYQERRVRTSLSEVNNMGYGIADWLAPNNHISTWDLVMPRFRKNDDECLFGLFDGRKTISNGCKLTHFLYDSFKKHFIQEQAKTRNDDTIISALRRTFLSLEKELGSFTTDTSVGASAVVCYIARTKLYVANVGDCLAIISRNNGQAYEITQKHIPLNPSETSRISAAGGFVSKTGLLNNKIHVSRSFGYFDMIPAVNANPYVSTIELTEYDEFVIMASRGLWDRMSYQTAVDIARTEKDDLMAAAQKLRDFALSYGASDDLMVMIIGVGDLFDKRDKRLRNMRGNGSGRGGSGQDGSGMDDGSSMMVGKNKRRGKEEFLGDSTLARLEKEVLPPVNQLALVFTDIKSSTLLWETQPEDMRSAIKIHDAVMRRTLRTVGGYEVKTEGDAFMVCFQNITSALLWCFTVQIQLLEADWPTGILETEEGLEVVEKGVVLYRGLSVRMGIHWGTPVFERNPITNRMDYFGPVVNKASRICNAADGGQICVSSDVLAALRNIPGVFNEDKRSAIPTDSSASISSVGGFSVNKDILQLKRLGFHVMELGERRLKGLETPEMLSFVYPKQLSGRMEVNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LHQ5</accession>
    <name>A0A167LHQ5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_70590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288527.1">
        <property type="nucleotide sequence ID" value="XM_018442301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LHQ5"/>
    <dbReference type="GeneID" id="29003207"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70590"/>
    <dbReference type="InParanoid" id="A0A167LHQ5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="149" mass="16763" checksum="7B686D9C7FA165C3" modified="2016-07-06" version="1">MKSINLHSYSFVKIAGDCPHIIENSGNQSVGQMFIILEPLISQIMCAHVCFHVDEISSDISLSFGLFHVSPKAVTKAEKSNLIVRNLGIGTIFMGTLIKRIVHMNFDIYERKHINQGSLGGFTSLFSILIIIGWCLNYRYIQQSSIQSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LQ10</accession>
    <name>A0A167LQ10_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Erg28-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_170962</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288919.1">
        <property type="nucleotide sequence ID" value="XM_018436453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LQ10"/>
    <dbReference type="FunCoup" id="A0A167LQ10">
        <property type="interactions" value="234"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167LQ10"/>
    <dbReference type="GeneID" id="28997359"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170962"/>
    <dbReference type="InParanoid" id="A0A167LQ10"/>
    <dbReference type="OrthoDB" id="6485510at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005352">
        <property type="entry name" value="Erg28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451:SF19">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03694">
        <property type="entry name" value="Erg28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD70879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="16410" checksum="AD27975B945AE829" modified="2016-07-06" version="1">MDFIMETVSNAFSTLPEGNLPKWLLFTSALGIFNSIQNYCTDSLTKRVYSGTPELVTPMTGRMFATWTWSVSMIRIYAAFHLEHRFMYELGIWTYVIALTHYMSELLIFKGCKISVPFMSPFVVAVSSLIWLASSYDYYVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M260</accession>
    <name>A0A167M260_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_170217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289597.1">
        <property type="nucleotide sequence ID" value="XM_018436294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M260"/>
    <dbReference type="GeneID" id="28997200"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170217"/>
    <dbReference type="InParanoid" id="A0A167M260"/>
    <dbReference type="OrthoDB" id="5556225at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="139" mass="16439" checksum="142FD88C3B8CDFD4" modified="2016-07-06" version="1">MENWSVPNNRYHKPIKGKILRNLLCKHGFDACLINEYATSRHCPRCCQLSLQTFKQVENPRPYRRTQIPTRTRHSLLRCTNLNCLENMDGSEVMHRLWNRDLAAVLNFRHILNQVSHDDTISERFTRVIQIGLNRIQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MQG7</accession>
    <name>A0A167MQG7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_145935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291584.1">
        <property type="nucleotide sequence ID" value="XM_018431562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MQG7"/>
    <dbReference type="STRING" id="763407.A0A167MQG7"/>
    <dbReference type="GeneID" id="28992468"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145935"/>
    <dbReference type="InParanoid" id="A0A167MQG7"/>
    <dbReference type="OrthoDB" id="2358153at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="481" mass="54237" checksum="AA0BFEB79C3EA4DA" modified="2016-07-06" version="1">MTENNLFQFAQVITDMPMHHSTSHQEDTLMRTRLQPPVMQLHSGQPRLAVRKYYGTDCECNEMQPRRGKNLPEGSLDSRAKKLNPQDKEDHDFTMGWLSENAHAIFRKEDGSVQGLRHLSEVSLCKAHSSTLYRAKKRFERSKAPPSPADSNGMDITEDHRHQQQQHNHHQQQQQQQQQQQQQQQQPTPYLDPYPYAVHHQHPLAEVVNGGLAAKVREISYQDNHYRHEPSPDFSSMTPSTSLKRKRLNKHMDHKLHQSASTPLYASSTAFLSHHHPPSPSVSVQPSANPRSPHPHSHPPPLPPTSSTSSHHHNQQLQQQQQQQQQQQQPPPPPPPQSSSSSHHDSFSSQLPPLHSRSHTLASLPQPHISITPSPSMPLSPPPAVETVSLRSVPQSDSSPMYYIRNLAITDAFTFRDLLAELDMTGSPPAGKRIIVSNAKNDLVFPLDQAIRSVIRRPTTSHVELCLGLAEKTAVDWSTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MSJ2</accession>
    <name>A0A167MSJ2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_20429</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291834.1">
        <property type="nucleotide sequence ID" value="XM_018439733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MSJ2"/>
    <dbReference type="STRING" id="763407.A0A167MSJ2"/>
    <dbReference type="GeneID" id="29000639"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_20429"/>
    <dbReference type="InParanoid" id="A0A167MSJ2"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF692">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="10"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD73794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="405" mass="44428" checksum="CF9F9B84025E07A0" modified="2016-07-06" version="1">MDPHGSPSLHKSSYTQSIFNSINILIGIGILALPLGFKCAGWGIGIMVFAFCCGLTNYTAKLLAKCLDADPDSHTYGDMGAAAFGIRGRIGVTMLFITELITSSVALVVLLGDGLDSLFPGYTTLEIRIFSFFLLTPMLFLPVRHLSYTSLLGIISAFSIILVIIVDGLSKRDAPGSLHESADTEVWPSDWMTVPLSFGLIMAGFAGHAVFPTVYRDMDNPKKYTTMVNWTYVATTIVYFGVAACGYRMFGSQTMQEITQNIMAVPEYNQTLNRLAVWLIAMNPIAKYGLTLNPVNLSWQIFLFRNSPVEGWCARGAWREPIITFLGKILVSMFIILLAFIIPGFDKVMSLLGAFFSFMISGIFPLICHLKLFGASISPAERSLNYILIAIASSMALSGTLWSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MUC6</accession>
    <name>A0A167MUC6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_158854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD74009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292049.1">
        <property type="nucleotide sequence ID" value="XM_018433867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MUC6"/>
    <dbReference type="GeneID" id="28994773"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_158854"/>
    <dbReference type="InParanoid" id="A0A167MUC6"/>
    <dbReference type="OrthoDB" id="2283974at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD74009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="235" mass="26620" checksum="532DF6789D06E97F" modified="2016-07-06" version="1">MVMAQQTTHLYTPDTSTLRQRGKTTLTDHDDDFEEAPFESTADISKLVPTSLRSRSDSMGSSDSSDFLHVDIHPDDPLRQAIETLRTEELPRYESGEINKDRFIDLAQAALEEATVEEDKKGVIQEVVETLLAQTGAPLVAEAISEQLRSQEVIEQLAESHEEERQRQNSSPVHAPEILKEPETDELSSKKMNDEARKTVVAAPERMVSEYLWRLFRVLLLASIVGLVYHFMRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MX40</accession>
    <name>A0A167MX40_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_144807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292399.1">
        <property type="nucleotide sequence ID" value="XM_018431296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MX40"/>
    <dbReference type="GeneID" id="28992202"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144807"/>
    <dbReference type="InParanoid" id="A0A167MX40"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="427" mass="49045" checksum="6FD8B9DA3834F4FD" modified="2016-07-06" version="1">MGKKEGLPGVYWEAAQEVAQNLLIVDSVENRLHAEEWESASTPSERHLLELHCLEYLDLVRGTIINPMHNLFLGTPKTLMDRWIKGEDIQDSNFAAMQKTAETMIVPVLLKDVLAKDRFKNWINFVDTCCLLIKPMITFNEVNTVHQFLQTFCTRYDELYNAKILTCNMHLHLHLRNKIRDFGPVYGYWLFGFEQFNELLKNLKTNRKIGFKETFMKRFIDVHKDDLVNSFLQSTRQTSAFPLLTKLISSFTPATISSIYQCTFHIQSFVKASEDPNVLVKGNEPLPPSTFPLSLKSATTMSDIHYAHLLQYYKVAYNNEQLVHFQQASESPYFVNNTITLLKYINILGQVYKGKDESGSHGSLVQAKFIGSTGEHIIAYMGQIQYIFTHSFIPPPTSSSLTPLLHTHCHPMQLLHNSQHTFAFIKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N7C0</accession>
    <name>A0A167N7C0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_143483</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293259.1">
        <property type="nucleotide sequence ID" value="XM_018430992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N7C0"/>
    <dbReference type="STRING" id="763407.A0A167N7C0"/>
    <dbReference type="GeneID" id="28991898"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143483"/>
    <dbReference type="InParanoid" id="A0A167N7C0"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000038">
        <property type="entry name" value="Zinc finger protein 624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF99">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF52.1-LIKE ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD75219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="92" mass="10483" checksum="C805C1395EBDB399" modified="2016-07-06" version="1">MPPPIRILHLTHLGWNIDSGGSSRAVIERLNPYPCKSICSTCGKDFSRIGNYTRHQKTHTKEKEKCFCQTCGKAYSNKSNLDRHTKIKHTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N8F1</accession>
    <name>A0A167N8F1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_64245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293360.1">
        <property type="nucleotide sequence ID" value="XM_018441261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N8F1"/>
    <dbReference type="GeneID" id="29002167"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64245"/>
    <dbReference type="InParanoid" id="A0A167N8F1"/>
    <dbReference type="OrthoDB" id="2277862at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="32896" checksum="91FAB20510F591DD" modified="2016-07-06" version="1">MSLLTSDAIIAKTMLENHAKTRDIQKATRDKVTGMRKMRISDINNLKGVSNLGGERLKSFPVAFAWVSDETETIYVWFSKALMNGLDFEFPVNKKLLCGWHMINNIAKMAKKTRKAGEDKNTCTNLINSMIFGDGAGKLMQKRELFRSLASCEDLKTEGLSEDGKNGAVKSFEEYFEKELMSCKEKWAGYLTNKLKHFDCVTTQRVESGHHAPKRSISALQSLDSSFEQICSYLLQFEGDCQDRRLDEELVTDARILADERPRGLVHSVSRMALFTIRAELLEEVTIGEAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NFD0</accession>
    <name>A0A167NFD0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CxC1-like cysteine cluster associated with KDZ transposases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_186013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293810.1">
        <property type="nucleotide sequence ID" value="XM_018439181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NFD0"/>
    <dbReference type="STRING" id="763407.A0A167NFD0"/>
    <dbReference type="GeneID" id="29000087"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_186013"/>
    <dbReference type="InParanoid" id="A0A167NFD0"/>
    <dbReference type="OrthoDB" id="2505730at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="604"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="700" mass="79851" checksum="4337CA7084156970" modified="2016-07-06" version="1">MYNPSKRTIKRRQRTAVPQFLLDYFSEDVPISGLNYIPTENPSVSEAEFSSPRLKYTYTRKKRARTMAVAPVETPSENIAASQTDLDVEIDFDTYEASQTQKRSLYNKWVDLLPQLADSFLRYLGRCKDGCLDKKVIAPLSHFLCSCTKFSKKNIYMFFLHSSGTFEVVFCGCKSIPEQLVEMGMLPASLNNVQYAIHFGLLEFMRDMRDVLATSGQGLADLYNKINLGAERQISKAYCQNLLHVFIRLTMIVEAKVEKLSPGFRESNCCPACPDVDSNVAVDDCRYVAMDGNFSLKCERRKDGEGDVGEELEQVEAQLKQVWIGDDVVKTYEKERAEEGVGRFDSNFHAGSGSLAKSIKYPIKGLFAASCARHESVIKLVDMETGEGFKYPLSIINQLLGDSGSDGQSADNSPNINVMYDVVCKLAKSLKANFPGLMEKSKLAVPIFHAYAHVQHCQVKLNPKYRDGFGLTDGECLERLWSYLNRFVTMTRKMGQANRKLVLYRAIKFRNETKKVELGLMLESKYVKAKRIIEESRKALEGFDCVVIEREWKQHVNKVEKSENYVDIADLMESGRKVQGNIALFLVNFTILRRLRELANDANGNHVKDEINRLKHEMEKLKAKIQEEVEGFQEPDEENTNLIKYIEENAQLGYNEFLAYKKTYSKMRLEPMFERIMIPRHCFTNLAISAQKKQNNTKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NK35</accession>
    <name>A0A167NK35_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_88121</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294158.1">
        <property type="nucleotide sequence ID" value="XM_018443687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NK35"/>
    <dbReference type="GeneID" id="29004592"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_88121"/>
    <dbReference type="InParanoid" id="A0A167NK35"/>
    <dbReference type="OrthoDB" id="5989317at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="309"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD76118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="494" mass="53660" checksum="D7F5E28239302B2F" modified="2016-07-06" version="1" fragment="single">KLLYITLYAVLGSAIPYLPLFYDESLRLSSNQIGVVLAIAPFVQSVACPVWTILADKKPSWHGPLMAILIAIGVTKTDESSTGLIFAAVLALIFAFFGQPVSALVDSAVLKILGEHKVLYGSQRLWGSISNGANILLVGLLISTMGINVAFYVFGVSVVCFIIIALFTRFGGGNDSTLDSTLSQINEESPLLKDQPRTTNYAIPPEQVEQNHTPVQNSFFSALSQVPTDHSRPEQHPSNYAFGPNLSRHDSVGSHTNTIYLEDGDRNMDQMMRVTTSMAAQDVQTEANELLLHTDGMPSLGKSTLTSPRVWTFLVTTLLFGIAYAMIAQFLFLYLRNNLGMESALIGWTGPIGGVAEVSTFYISKQLFDNFSVTSLISFAHIVLILRNFVYTWLSPNQFSSTVIALSMQLVSGLAYAMIWSTSVSEVDTFFPADQRAMAQGILAALFSGLGYGLGCIIGGMVYDQYGVTALFEVSAAIAAFSLGVFLLGRWSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NNY2</accession>
    <name>A0A167NNY2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycosyltransferase family 5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_76095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Amyloplast</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294414.1">
        <property type="nucleotide sequence ID" value="XM_018443122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NNY2"/>
    <dbReference type="STRING" id="763407.A0A167NNY2"/>
    <dbReference type="GeneID" id="29004028"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_76095"/>
    <dbReference type="InParanoid" id="A0A167NNY2"/>
    <dbReference type="OrthoDB" id="512920at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45825:SF11">
        <property type="entry name" value="ALPHA AMYLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45825">
        <property type="entry name" value="GRANULE-BOUND STARCH SYNTHASE 1, CHLOROPLASTIC/AMYLOPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0035">Amyloplast</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Starch synthase catalytic" evidence="7">
        <location>
            <begin position="104"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="6">
        <location>
            <begin position="466"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD76374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="674" mass="76043" checksum="63CC5A5C289025FA" modified="2016-07-06" version="1">MSFAGDPINSNEHRKWTPLSIRLIIKTISSRNPLGFFQKRSWWQLLGLFIGFLGIVEIILVITGLTMLQKTQPDVRVALRQYKPISYKHLSTRLPPNLKPGTTVYHVTKEFGPATMGGMGQVLTAMASAQQRTGRLDVSVIMPMYSFVRSRNRVRRLVDLRVDITDTRGQTKPVEFSVYLMKYPVVPNATLESEVINVYLIGPGKLSPLNRAFRAKAPVEIYSSPKELPQEWKDQYFLKAVGQLISHLTTAYDEQPLFAPFGKAPQVDVVHLHGATNAYLTQYLQTLAENDHLGSLRPAVVYTMHDYLDELQYTNKVSNVQRFGQVDPAYVYGDQMFMASLAIEKADVVTFVSRSMVADMLEGRLDFYLKELVMDSLLRKAMQDRFFGISNGVDFTRLNPFDHPQLVREQLAFPPYARLLLKNAQPESSPLPWMLSNSPEDNASLAKDKVKQFLIEKGQLSPEDFTRPLVLFVGRFQYNKGLEIFEEAVRLFVEHDMKFAIIGQPNNYPLSWIKDLAKKNPEHVVLMSSASAQSKWLTYYRAAADFVFVPSLTESFGLVAVEGLSFGAAVISTGAGGLKEFLVDRPRQPGKSILVGQTSNAYLFEPSTLSDAIQDASVAYKEWQESQALREVHVLRMMQSALLLGWEQGDLKGPVYDYMRAYAIALAVRHTSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NPJ5</accession>
    <name>A0A167NPJ5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_158305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294440.1">
        <property type="nucleotide sequence ID" value="XM_018433762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NPJ5"/>
    <dbReference type="FunCoup" id="A0A167NPJ5">
        <property type="interactions" value="578"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167NPJ5"/>
    <dbReference type="GeneID" id="28994668"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_158305"/>
    <dbReference type="InParanoid" id="A0A167NPJ5"/>
    <dbReference type="OrthoDB" id="1539250at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3260:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD76400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18227" checksum="04D997CA95759373" modified="2016-07-06" version="1">MPHSFGLRARTRHMFSRKFRDHGAIPLSTYLTIYKTGDIVDIKANAAVQKGMPHKFYHGRTGVVYNVTKSAVGVIINKRVGNRYIEKRVNIRVEHIKHSKCRQEFLDRVKENAQKKQAAKDAGVIVSMKRAPVQPRTARYVSTVKNVPQTITAIPYETLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NPV8</accession>
    <name>A0A167NPV8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_143392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294458.1">
        <property type="nucleotide sequence ID" value="XM_018430977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NPV8"/>
    <dbReference type="GeneID" id="28991883"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143392"/>
    <dbReference type="InParanoid" id="A0A167NPV8"/>
    <dbReference type="OrthoDB" id="10403247at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="358" mass="41704" checksum="5BAF7115DC1B6913" modified="2016-07-06" version="1">MSLDKPIYASVKLNPTMHMWQTPDLISVGHNTGHSAVPLQSARRLTKNRVPLPGVSRLVNSVRRLRTRNSFTPTHFSWTDLPRATFLFRLKRSTSNFPSDQEPSAGSKSVRKARLHFKKPIDRRAMRKPNNLDISRTNRPGLNRLRSRTKKRRPSVLKSWAKIDRQQIHDQMQRFRVPLRWTDSVASFSINTDLKEISPEICLHNLTKSIKRLQYLIEKEVEAIQFNQQEVIDYSAKLKQLDIDSQRLDSLVEYGRVEVMSGFRTTLKAIEQETSWLSHAQRKQQKTTARIESYGQRVNHNIRLATLKLNIQSAQSIEEMRLYIKDWKFRSVFLFMSFAFCILAISTLPTRQALLLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NUY7</accession>
    <name>A0A167NUY7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_185803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294706.1">
        <property type="nucleotide sequence ID" value="XM_018439148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NUY7"/>
    <dbReference type="STRING" id="763407.A0A167NUY7"/>
    <dbReference type="GeneID" id="29000054"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_185803"/>
    <dbReference type="InParanoid" id="A0A167NUY7"/>
    <dbReference type="OrthoDB" id="2287482at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="409" mass="45058" checksum="91270BF8914D9E7E" modified="2016-07-06" version="1">MSTVLSHSESVMPLETPSSYKEIIKQLAAELPKPYGAIPPLMKKRRKKKNREVNTTTTNSTTTTNTTTATTTTANSVEHPSNEPKQTMRRMSHVEDWIVVDSKESLPDEEELVSNSPFRNFLSADFFTQVLPLHMPPPSLSDPGTLEDDEEDEEPASSIIPEQGKGQRLELGQESGSEPASSSASASASASASASAPASASASVLVSVSASASVPVEVRRGSDRHSRKSRRTASPDWKSDGEEETAIVLPKELVRRHSISSFSKALLPSTSTTASSVMSSSPPQADGHRARWMETITQLRRSLVQSATPKTKTKKKKTLIPMPLPPRRPSSHRRRSEATTQPRFNPDTNTYTRDTRSNPDHLRMISAELNMMRARKLLSPLKPRGFLPRRKDPFVRGLDRSRSGLRSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NV03</accession>
    <name>A0A167NV03_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_165191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294709.1">
        <property type="nucleotide sequence ID" value="XM_018435178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NV03"/>
    <dbReference type="GeneID" id="28996084"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165191"/>
    <dbReference type="InParanoid" id="A0A167NV03"/>
    <dbReference type="OrthoDB" id="10592231at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="132" mass="14987" checksum="3AA1EC880147C475" modified="2016-07-06" version="1">MSNLTRLDMDIPHNLTTTTTTTTTTSLRQTKSVSYTQARPPHSPKRTHSEPPKKRRSAYEPLPVEKVPKVPSKRSLSHAINALTDLIRKPKRTWLNTTWTDEMPLAATISSSTQKPAERAENWWATTPRLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NWJ4</accession>
    <name>A0A167NWJ4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_157995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294796.1">
        <property type="nucleotide sequence ID" value="XM_018433712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NWJ4"/>
    <dbReference type="GeneID" id="28994618"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157995"/>
    <dbReference type="InParanoid" id="A0A167NWJ4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="61" mass="7172" checksum="E51BDA5A82E1C886" modified="2016-07-06" version="1">MKAAFTGMRKLFIPRVYLLAIIKNLSNVSMAKKLIMYLDKYHCSADKIWFHNLIFVLPLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P9A6</accession>
    <name>A0A167P9A6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_164417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295548.1">
        <property type="nucleotide sequence ID" value="XM_018434999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P9A6"/>
    <dbReference type="GeneID" id="28995905"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164417"/>
    <dbReference type="InParanoid" id="A0A167P9A6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="158" mass="18420" checksum="59C82F0A33EB99B0" modified="2016-07-06" version="1">MFRFEFSGFKQPVVFSVIIWYPPSFLPSQYEEMGGFSYYMFMVSILLCSKKGPTLQTNHIFIYFALLLKVATVEFNLQNYTNIMTYYIKGECIDPHSTFITIFHMRNYSNLNRLVSQLKRNISNKVLLKCLCISPDAEPQSLCYLKSVDTEVIIDRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PAH5</accession>
    <name>A0A167PAH5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_17339</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295614.1">
        <property type="nucleotide sequence ID" value="XM_018437022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PAH5"/>
    <dbReference type="STRING" id="763407.A0A167PAH5"/>
    <dbReference type="GeneID" id="28997928"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_17339"/>
    <dbReference type="InParanoid" id="A0A167PAH5"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="438"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD77574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="538" mass="59890" checksum="D564F7F4004D48C7" modified="2016-07-06" version="1">MVFVGAPLPEPIPVISGYDLLFTNARNLPLDRKVFIDNDNVDNYITYGGLVTQVTKFSSGLQQIFNFQRGDVVAICSPNQINYPVALHGTVAAGGIACPVEHTLTTDLLVKDFMTVRPKLIIAHKHTLGRCLEAAEIIGLPKSHILLFGPRKLRGVMPYKHILYSYGVTRPPVQLTREEILTKPAFLYFTSGTSGVKKAVMMSQFNINACLMAKDAWSKVEARAVSHVEFHHASALIINLHYCIMHGVETFLLHRYNIRDLCSTIQKYKVGLCASPPWTVTYLVKDPVYRSYDLSSLNVFICTGAFLDNSSARAFYDRFGIPVINKYAMTENTCFFKTILETVQAGSLGVVQDGNILKIVGDDGQEVGPGEMGELCVKGPTVAQGYYLNPEKTVEAFDKEGFFHTGDLIRGDENGHFFYVDRAKDLIKYHLHHIYPGEIEDILMTHPLISESSVIGMYSRDLATEMVTAFVVLVPGTKRTASLADEICEYANSRVSDIKRLRGGVKFLEKFPRTAAGKILRGVIRMNAMEQDDELKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PBU9</accession>
    <name>A0A167PBU9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_164519</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295658.1">
        <property type="nucleotide sequence ID" value="XM_018435021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PBU9"/>
    <dbReference type="STRING" id="763407.A0A167PBU9"/>
    <dbReference type="GeneID" id="28995927"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164519"/>
    <dbReference type="InParanoid" id="A0A167PBU9"/>
    <dbReference type="OrthoDB" id="5393181at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028143">
        <property type="entry name" value="Get2/sif1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263:SF1">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08690">
        <property type="entry name" value="GET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD77618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="317" mass="35189" checksum="3C9CCC0BFF51D2BE" modified="2016-07-06" version="1">MTELTEQEKLERRRQKRQQRILASAGDRLNRITGTAFPNRSSPTPSPSTSASSLAPSESYSKELPRSRSPSPALFGSAQPVLPADPAKRVQQQRRASDEDPCESLGAPPPLSTNDPQIRSLEEFDAMLGLPPSSFSQQRQPQMDNLNALNEMFGGQLPFNPAMLAGMQGQQQQTTEVTSDPSRLYWNLIHVSSMLWLGIYAVYTEWNTVGKDRFASLLWMNPTESISNGFTGVQFPLFWYFVTLELMMQAAQMFFQEGQAHSGSMLGSLAAQLPHPFSTIIITGLHYRTLWSCLVQDCCILVFVIGIAEVISAILVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PZ05</accession>
    <name>A0A167PZ05_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_176887</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296836.1">
        <property type="nucleotide sequence ID" value="XM_018437825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PZ05"/>
    <dbReference type="STRING" id="763407.A0A167PZ05"/>
    <dbReference type="GeneID" id="28998731"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176887"/>
    <dbReference type="InParanoid" id="A0A167PZ05"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF77">
        <property type="entry name" value="CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD78796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="402" mass="45179" checksum="DECDCC22E2B9AC7E" modified="2016-07-06" version="1">MPSIFSPDFLTSEQLANLKLYKYAAVDLSFTSRYLLVHYWNWAVGFFPMRMAPNLITLTGLMFMIINVAFAAGLSNEMEDGPRWIYLSFAVGFWLYSTFDNVDGKQARRTGTSSPLGELFDHGCDALNCSFAVLLQTTGLGLGQTHSTVMLYGIAMLGFYLSTIEEYHTGILYLGYINAPTEGVILTCVLFIFSFIYGTGIYKLPVSTLVKMEGLPTCVANLPINQAIVWSIGLTLIFMHTPSCMYAMYKACRQKNKPFVRTMLNDNLPIIIYTISFYLWATSPYSIILSHHHFFLYSITTGIVFGRIASKVILAHLTKSTFPTFTVLLVPMIVGAILTNLPRVPGVAPILTPQSEHYFLWGFFGFALLAYLRWAVVVIKSFCSYLNINCLTIPKKYSEKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q1Z4</accession>
    <name>A0A167Q1Z4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_140981</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296964.1">
        <property type="nucleotide sequence ID" value="XM_018430500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q1Z4"/>
    <dbReference type="FunCoup" id="A0A167Q1Z4">
        <property type="interactions" value="374"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167Q1Z4"/>
    <dbReference type="GeneID" id="28991406"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_140981"/>
    <dbReference type="InParanoid" id="A0A167Q1Z4"/>
    <dbReference type="OrthoDB" id="5963193at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD78924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="384" mass="42890" checksum="A2A13919272834F3" modified="2016-07-06" version="1">MSDWAVNLLSSRLLGYLHMECQDAACYGVVAAHKVCFAIVIFHMLLGLLVLGVRDSREKRAVIQNGGWGFKVIFWLGLVTGSIFIPNEFIFVWGNYISLIGAFLFIIFGLLLLLDIAQAWTEICLDKLMASENNRWKYMLIGTTLSQFSGMTTLTGLLYGFYGTNGCTLDLFLISFNLALTLFVTLLCFFPAIQEASPQSGLSQASIVTFYCTYQVFSAVANRGNDESCSPQSIGLEIVAVVLGTVISFAILVYLATRSGSQEIPYDGERGTSREYLVQSVDHGTIPRSNLDRYDEQEELSGTVYSYSFFHFIMAIAAMYAALLITRWNKIVVETQPTELVKIEHTYAAVWIKIVSSWISYALYVWTLVAPIMMPDRFLVSSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QPS2</accession>
    <name>A0A167QPS2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SWI5-dependent HO expression protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_179380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298070.1">
        <property type="nucleotide sequence ID" value="XM_018438138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QPS2"/>
    <dbReference type="GeneID" id="28999044"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179380"/>
    <dbReference type="InParanoid" id="A0A167QPS2"/>
    <dbReference type="OrthoDB" id="2276661at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD80030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="34704" checksum="FF825AF7A6E0B2C1" modified="2016-07-06" version="1">MQVSHDNNVSRINYGHLFRYDQMNPRQSSKHDLNQTAKVQSGKQLTADSIEPEESRSARTKGMVSVLKSKHEVLTRQRDAMALEVKTTAETRDMHLASQSVFRAENDTLRLEMNRLAMEIDAKQTAIDSLKTTADDQKTYASSVQLAAETQRMGTAELKKKAGEYKQAISRAKLKAAQAQAQTQALKDSLKGLSGQRRHEKLAHEQLLSLLSTLKKEGQESIERLQQGGHELKSLGDERSSLLESTRDVVKNIESWHDKNKTAFKTEVVKLGEALSPCTDKDKELKDSVEQCKNQMDSLVDRIRKTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QVM0</accession>
    <name>A0A167QVM0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_178552</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ADIP family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298388.1">
        <property type="nucleotide sequence ID" value="XM_018438003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QVM0"/>
    <dbReference type="STRING" id="763407.A0A167QVM0"/>
    <dbReference type="GeneID" id="28998909"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_178552"/>
    <dbReference type="InParanoid" id="A0A167QVM0"/>
    <dbReference type="OrthoDB" id="312015at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052300">
        <property type="entry name" value="Adhesion_Centrosome_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021622">
        <property type="entry name" value="Afadin/alpha-actinin-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46507">
        <property type="entry name" value="AFADIN- AND ALPHA-ACTININ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46507:SF4">
        <property type="entry name" value="SSX FAMILY MEMBER 2 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11559">
        <property type="entry name" value="ADIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="445"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="75"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="445"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD80348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="484" mass="56131" checksum="7ED2F39266823696" modified="2016-07-06" version="1">MDATQDILFDFESFGSPESPLDESTNYKKDGFCTPANLASSANHVNIQLTAQGYPVPLVFKSNQPEDACKIINCLHDLLQDKKNDEEQCNELSNTISQLKRDREVLQQKFDLQSQELTKIKREKELLGSKVDSIQKNLKTEKEQTKSMKDELNKAKNNMQYIKAQYAHETRRHELEHAKTRDRLSKLMREKIKPVLPSIIVNDPPPGLAGHPKENAAEEERAMFEDLIIKTSAREMDARKESEAFRKAFVAVYSAVRNLLDRQILEDESHTGKESKLSRKDMSAFRLPFDFGGSEAVQHIHDLLVRLEEEWGNQTRNQTVYTAEDVLKRDRMIRQLEHDIEILIKTFDEATVEYEEKTRMYKRFEEGGFFDVILPAIPNEQSDSEDFALEIQLDSQNRLERLRKTALKDQRRVTDAAIRLGNERKMLKAERWAFEEMKRELKMKDILSERESSPEDTVRPQHPLPSPSRPRKRHRPGLGKAPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QYB1</accession>
    <name>A0A167QYB1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_61515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298504.1">
        <property type="nucleotide sequence ID" value="XM_018440813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QYB1"/>
    <dbReference type="GeneID" id="29001719"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61515"/>
    <dbReference type="InParanoid" id="A0A167QYB1"/>
    <dbReference type="OrthoDB" id="2290665at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD80464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="416" mass="48042" checksum="E28DF7A0B61D576F" modified="2016-07-06" version="1">MSNVKKGSHMWNERLVDEQIRITCRKIIKKERKKLLMMIIMIWNNNYIMICKLSIGPFFTTTVYLYLRDLVNLKFKSRPTPPSGLHASGCLVWFGLVWSGLVWSGLDSDSDSDTSAGLITDNVIQNLVHKISRDYNAVREFRLDYRLPLSTKIKTKSLLLALQLNLNTSSITLVSNLLDVQLANLCTNLEDYLFSLFYSNLLSDRQTALRIPFTIEDYVCDARTNMAYIEDVVVLLWTTPFLPSEQFESFNVQKTLFVVNNATVNEDRQYTGRNYTDYVDGLNGFLFNKQSGYQKRNYDRGGSSEMMGYYCTTKHTKLKQTSLETPIRYTATKTFCENKNNTNIKNKNKNTNTNTDTSMNKNKNKNKNMNMNKKKAHSYSPAHRHRTLEKVTTSIPKQTGVYPVQPILRVMCFWPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R2F0</accession>
    <name>A0A167R2F0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="2 6">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_156953</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="2 6"/>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298729.1">
        <property type="nucleotide sequence ID" value="XM_018433537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R2F0"/>
    <dbReference type="FunCoup" id="A0A167R2F0">
        <property type="interactions" value="287"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167R2F0"/>
    <dbReference type="GeneID" id="28994443"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_156953"/>
    <dbReference type="InParanoid" id="A0A167R2F0"/>
    <dbReference type="OrthoDB" id="73846at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="8">
        <location>
            <begin position="196"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD80689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="326" mass="35927" checksum="5C118F0AFF4A4059" modified="2016-07-06" version="1">MHFHILGTGAVGCHVASLLRMTNHKVTLILRSQKALQDFKAHNQSISLTLKGKSASVSGFDSMVLPSAPSQGPPIECLVVATKAQSVIEAVSPLKSRLTKNSTLLLLQNGMGVVEELMDTVWHGQTSPRILVGVNRHATQRTSAFKIINHSGWNDPEGLVVGERLQQGESPRDDSPVLKTLSEIKDLSLSIVPWEDLQNRMAKKLIINASINPVAALLDFTNGGMIDDNPYTMNLMRELCYEAYSVLENLLPGETAESLFESVIGILQITRQNRCSMVQDMNAKRPTEVDYINGYLCRIGKNQGKILKVHQTMVDLIHAKERVAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R5S4</accession>
    <name>A0A167R5S4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_61960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298954.1">
        <property type="nucleotide sequence ID" value="XM_018440881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R5S4"/>
    <dbReference type="GeneID" id="29001787"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61960"/>
    <dbReference type="InParanoid" id="A0A167R5S4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="102" mass="12098" checksum="80F321F75B3E2B2B" modified="2016-07-06" version="1">MAVVASVPHLDVQTRNREYNIIFFFEKCTRSEYNSRNGCTNQVECKWFIEAIKNTGPMYHLTATHGINDENKNILYLRRTGVFYDFGKYLKLANLEHLYWIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167RFL6</accession>
    <name>A0A167RFL6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_73426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299579.1">
        <property type="nucleotide sequence ID" value="XM_018442854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167RFL6"/>
    <dbReference type="GeneID" id="29003760"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73426"/>
    <dbReference type="InParanoid" id="A0A167RFL6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007891921" evidence="1">
        <location>
            <begin position="18"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD81539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="315" mass="36639" checksum="FC35A9B4F43540DB" modified="2016-07-06" version="1">MLNWVQIWTLQWPVVKLFNLPMVFPSRCLGPSMTASIIFLELYFSYNQKELLDSNIFFKRQKLCRKCQYKKTVAHGHGESVSEKNCASSLFVVTFPTKFLTFEKSPIITIDTEKEAGEKESVEDQPVEEYDWELLDLDIDTMIAVYYNSFLTWRPDAEKNLRRLYRGDSRSSIMHNKRKMKEELEANKDKKVRTLADFGFSVPVVPVSPVTEALTVYKQLKDEELEEIREAYEKISEMIKPSVSSDSELGKFALFEVSKHIVLKEYFQCLLNNCKKIEASEKAAEIFRTTPSKYCGDIVHGWAKEFLQFGKTSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N864</accession>
    <name>A0A162N864_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_24224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288659.1">
        <property type="nucleotide sequence ID" value="XM_018439833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N864"/>
    <dbReference type="STRING" id="763407.A0A162N864"/>
    <dbReference type="GeneID" id="29000739"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_24224"/>
    <dbReference type="InParanoid" id="A0A162N864"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF160">
        <property type="entry name" value="ERAD-ASSOCIATED E3 UBIQUITIN-PROTEIN LIGASE COMPONENT HRD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="458" mass="50617" checksum="8BD46F116B43D21C" modified="2016-07-06" version="1">MSKVPFALSWLIRTAENYNCAASQFCLAEAYHDGVGVPRIAGEAFKWYSKSACQGFSRAQVMVGHFYKEGFAVQQDYRKSMSWYQLAVTQNSPDAIYSIGCCYSNGIGVSQDPKVAFKWFKRAAALNYPPAQSAIGSCYSNGIGVDQNPALAFEYFRLAAEQGYAWAQFYLGMYYHNGSGGIGVNVPMAVHWYTKAAVQGQSMAQHHLGFCYQNGLGVTQNLTDAIKWYGRAAAQDNVAAFHSLGYCYENGIGLAVDSFKAVYWYKCCADLNHPPGLISLGFCYGEGIGVQRDNREAIRCFRRAADLGSATAQNLIGFAYEKGLGVSKDLKKAVEWYLKAAQQNYSISQCNVGYCYSNGLGIDKPDQTEAVYWYSKSAHQGNARAQWKYGVHLLSGKGVRRNSKLAFEYFVKAAKQGLLKAQYHLGLCYENGVGTSVNYNQAIIWYERATLVSVSSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N957</accession>
    <name>A0A162N957_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_70359</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD67004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285044.1">
        <property type="nucleotide sequence ID" value="XM_018442265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N957"/>
    <dbReference type="GeneID" id="29003171"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70359"/>
    <dbReference type="InParanoid" id="A0A162N957"/>
    <dbReference type="OrthoDB" id="10644540at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007837723" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD67004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24231" checksum="E99E15C9D1F731FD" modified="2016-07-06" version="1">MKTIIVLFNILALSALNCCAQTSLAAPSRVNHTIQSNSTRNNSSSQTFLTVPTAQTSSTAIGTPINSLPISSNRPVASIDTISAPPIPNENNTNVSQSVNNFSTRTSIVLGITLGSITLVFLLLGGAFLFLLLKRRRRAKEYAIKRARELDYDGSLPWSQASMSTNSRSDLTRSSNNHDPLDHLDAASQNEKYTKISLIDPSHPSFVYAIRQAEAISSDPTSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NBM8</accession>
    <name>A0A162NBM8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_174013</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285724.1">
        <property type="nucleotide sequence ID" value="XM_018437170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NBM8"/>
    <dbReference type="FunCoup" id="A0A162NBM8">
        <property type="interactions" value="385"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NBM8"/>
    <dbReference type="GeneID" id="28998076"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174013"/>
    <dbReference type="InParanoid" id="A0A162NBM8"/>
    <dbReference type="OrthoDB" id="2534523at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001238">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF34">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="9">
        <location>
            <begin position="802"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="536"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD67684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="943" mass="105497" checksum="8F24331A3EE1DE44" modified="2016-07-06" version="1">MLRHCRRLYLCHIRPLVSFRSLSSASPLYKRITQANAEVLFAELPPSLPPLESRQAASGSMVLDTVREYTKKYPLCVLLIQVGDFYELYESHATHYAAQLDLKLTKKDMATGVTVDFAGFPLRSLDRYLDMLVNRLGCRVALCEQHGTATRDDGSVMGKRRRVTRIITPGTVIEERFLDAISSNYLLAVLPSTTFGKKNDDDDNDDDYEVGLAWIDLSVGEFVLQQSRLQAFKDDVARIRPREVILPTWMKPRTGGGGGGGGDSHPIMQSLGQDPSIAITYQGDATFDSQKGHELLESIISTPDATKQDDVDHSFEKEEEAVLSDGLDVAAAVALLHYIDSTHMGERPRLQRPVRFSPEAMLRIDSAAMGSLELVRSLKDGRRADSLLGTIDCTITSAGSRLLTTWLTSPLTSMGRINTRLDIVDFFASEPNILGSIRRTLHLSTDAQRALQRLAVRRGQRSDLVEISSTFEAIRSLQHQMASVFSAQPLGRYTSAVKKLFKTLDPHQDLVDFIQSAVNPDWIPDKERERAYGYVNRNFNPELKKLHRRLDQLESERDRITSELKAMCGNSVNLVSQGPYKHIVELNASQAAKLTSVYSCTLVNKTKSKHRYQTDFWTPLSVQIETHQNLLVEMERQVFEQVVQRVLDHSSTVLDSCKSMAQLDVLTSFAWLSRERRYVRPTLSLANQTTIVGGRHPVVEAHLARKGREFVKNDLNLGQDQSVWLLTGPNMGGKSTFLRQNAVIVLLAHIGCFVPAKYADIGITDRIFSRVGASDNLAQDQSTFMVEMVETATILQQATARSMVIMDEVGRGTSTTDGFSLAYAILYDLCSRIGCRTLFATHYHELARELDNKEHSAFDKIKCFMTSLHESEDGSFIFLHHVQPGVCTQSHGLKVAQLAGLPPSVVHMAQGMWAHLNQTGSMSPKPYSIYSKQKDDHEKDVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NCH6</accession>
    <name>A0A162NCH6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_127760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018429184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NCH6"/>
    <dbReference type="STRING" id="763407.A0A162NCH6"/>
    <dbReference type="GeneID" id="28990090"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_127760"/>
    <dbReference type="InParanoid" id="A0A162NCH6"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042627">
        <property type="entry name" value="FBXW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44436">
        <property type="entry name" value="F-BOX/WD REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44436:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="99"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="241"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="288"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="329"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="369"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="409"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="449"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD68074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="553" mass="62418" checksum="68B2A3FF483DD010" modified="2016-07-06" version="1">MNLVGPEDISPPATPPSNSPARPTQRHRISYSDFSIGENAAQLAAIFDDHELNHLFQLKTSFQQLTSQQRQFLLYEIINCCDNSQLAYLSNLIAPRLKVDFLKELPIEISLHILSFIDDPKTLGRIACVSTFWNSLLKDEATWKALCMKHQYRRRNSSICGGELLDPPTHRLNFSYREYFKRKYNIAAAWAHGGRVKVIEEGFSDGLVTSLQFDEKYIVVGCDNHRIEVFDTRTGKKVRSLEGHEGGVWALQFKGGDKRDPERVLVSGGCDRDVRVWDLDTGSQRHVLHGHTSTVRCLKMKDKRIVVTGSRDTTLRVWDIKRGILLHALIGHQASVRCLDIAGNMIVSGSYDSTARVWDLQSGRCRHTLAGHYSQIYAIATDGYKVVTGSLDSQIRVWSVETGQCLNTLRGHTSLVGQLQLSGMTLVSGGSDGCLRIWDLQSYECIQQISAHDNSVTCLQFDDRRMLSAGNDGKIKLWDIRQGRLIRTFTQPAKTVWKIQFNDTKAVVVMQRQRSSNSDAEDGKTVMEIHDFDVMKMPPETQDADVLMGTHFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NCX5</accession>
    <name>A0A162NCX5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_73035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286274.1">
        <property type="nucleotide sequence ID" value="XM_018442762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NCX5"/>
    <dbReference type="GeneID" id="29003668"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73035"/>
    <dbReference type="InParanoid" id="A0A162NCX5"/>
    <dbReference type="OrthoDB" id="10407996at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="436" mass="51410" checksum="6E68E9B7B402DBFC" modified="2016-07-06" version="1">MKSNEAKKSLTTVYCIPIDIGGFSLGFDKYITSDSVRVGHSVEALRYQVSQMEQQREIERQEWKVIEIEHQRREQSMLKQIQYTQAQLEHVLAECRIESINPYPEQILHPQNQMHERGRWRRKSSAGFVHTPPIQRRVRSKSSEYPKRHLPDWNDNRPVQPADYLSGNLYQGGNPIEQLQQDFVTEDIPPRPIYTPYARQNYQGSPQETQFNSQQTYYDGNNDEDSDDEDEEYSFSRTNPNTSTRQTSSWIPPIRTPFESHRSRPLTTPQRNPLSRHQSKNQYEPQSPVLQPAAPKENQLPKQRNYDPPFSMPMPMPMPMPMPQPRIRHEQPRSYKMSTGYLPSRPSTISGYPIHPLQPTHIMSPRHTEYPFHSFIQHPLDYRYLTHNYSKHQSWPPQMYTLPLVGHPMHTWRIPSQFAMPVSTVYQRRPYMRGTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NEB9</accession>
    <name>A0A162NEB9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNL-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_95282</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291568.1">
        <property type="nucleotide sequence ID" value="XM_018443890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NEB9"/>
    <dbReference type="STRING" id="763407.A0A162NEB9"/>
    <dbReference type="GeneID" id="29004795"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_95282"/>
    <dbReference type="InParanoid" id="A0A162NEB9"/>
    <dbReference type="OrthoDB" id="512667at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024158">
        <property type="entry name" value="Mt_import_TIM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007853">
        <property type="entry name" value="Znf_DNL-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922:SF13">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05180">
        <property type="entry name" value="zf-DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51501">
        <property type="entry name" value="ZF_DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNL-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD73528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="73" mass="8414" checksum="0D4841E130A46165" modified="2016-07-06" version="1" fragment="single">KDKIMIGFTCKVCDERSQHVMSKLSYTKGVVLIQCPKCENRHLIADNLGWFRDTKVNVEDLMKENGEEVSRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NFE6</accession>
    <name>A0A162NFE6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BolA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_150078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD69084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287124.1">
        <property type="nucleotide sequence ID" value="XM_018432393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NFE6"/>
    <dbReference type="FunCoup" id="A0A162NFE6">
        <property type="interactions" value="368"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NFE6"/>
    <dbReference type="GeneID" id="28993299"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150078"/>
    <dbReference type="InParanoid" id="A0A162NFE6"/>
    <dbReference type="OrthoDB" id="4983at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045115">
        <property type="entry name" value="BOL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735:SF27">
        <property type="entry name" value="BOLA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735">
        <property type="entry name" value="BOLA-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="10122" checksum="3BF76C429E1452F9" modified="2016-07-06" version="1">MADHSGVTADSLKTAILQRLEAEHVEIIDLSAGCGQMYEVVIVSPLFREKRLLARHKLVNEKLKDEISKVHAFSQKSYTPEEWEKKTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NH17</accession>
    <name>A0A162NH17_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_78339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287574.1">
        <property type="nucleotide sequence ID" value="XM_018443359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NH17"/>
    <dbReference type="STRING" id="763407.A0A162NH17"/>
    <dbReference type="GeneID" id="29004264"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_78339"/>
    <dbReference type="InParanoid" id="A0A162NH17"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053043">
        <property type="entry name" value="Ras-cAMP_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014:SF1">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD69534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="255" mass="28921" checksum="701DE5724710BC54" modified="2016-07-06" version="1">MLDLLPPLLALSVQTLNTMREVEADDLRTMWTLFTKCKGQLEHGQRLENMAWRLWHHESTLTKRTDIACIERPTDPIQRQSPIDHFLSCLATPSMTTTEPNAVQFQKCRSSPPIPTPAISPNATPWSDSDPVNVVPIEVLSVPDSYDSPILNSQTKDKHTEDTPENDTTFAKTQPTLAPRQSLLSILFHKPPSDSANTDITNQQPAQLFMYMPRNISESVQQDPALEDIQNSPNIKRSSSNRHQDSEWRESFHGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NLF5</accession>
    <name>A0A162NLF5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_110691</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293348.1">
        <property type="nucleotide sequence ID" value="XM_018428179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NLF5"/>
    <dbReference type="FunCoup" id="A0A162NLF5">
        <property type="interactions" value="236"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NLF5"/>
    <dbReference type="GeneID" id="28989085"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_110691"/>
    <dbReference type="InParanoid" id="A0A162NLF5"/>
    <dbReference type="OrthoDB" id="3427at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007837828" description="GOLD domain-containing protein" evidence="10">
        <location>
            <begin position="29"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="38"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD75308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="231" mass="26462" checksum="0460C4DA3D2F97B7" modified="2016-07-06" version="1">MAFALNKTRLSAALLFTILLICANVSEALYFYIDGSEKKCFIEELPKETMVTGTYKAEQYSDAQKQWIVSPELKIQITVEELPQGHVVVDRQGDASGRFTFTSAESGDHSICLAPVSTAWFDSSRTVNIIGYMHKITFDMDFDDPAGSEQHDHAGTLSDLAMRIHELNERVQDIRREQTSQREREAEFRDRSELTNARAVWWTIAQIIILGVVCVWQMRYFKHFFVAKKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NLS5</accession>
    <name>A0A162NLS5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHYBLDRAFT_89373</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2E)-butenoyl-CoA + L-lysyl-[protein] = N(6)-(2E)-butenoyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:137954"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:53909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:131780"/>
            <dbReference type="ChEBI" id="CHEBI:144968"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:24181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:45949"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293428.1">
        <property type="nucleotide sequence ID" value="XM_018443713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NLS5"/>
    <dbReference type="STRING" id="763407.A0A162NLS5"/>
    <dbReference type="GeneID" id="29004618"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_89373"/>
    <dbReference type="InParanoid" id="A0A162NLS5"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106226">
        <property type="term" value="F:peptide 2-hydroxyisobutyryltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140064">
        <property type="term" value="F:peptide crotonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF219">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="18">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="17">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAD75388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="238" mass="27257" checksum="A85DC4C1C582B863" modified="2016-07-06" version="1" fragment="single">RARNVDKVLYGIYEIGAWYYSPYPSEFGAFLDRLYICEHCLNYTNKEAQLKIHKASNLGILLLPGKVIYQDGTLKIYEVDGREQKLFCQNLCLMAKLFVDHKTLYYDTEGFKFYILTEQIKQSDIMVGYFSKEKLSYDNYNLACIMVLPTHQRKGYGRLLIELSYELSKKEGVVGSPEKPLSSLGALGYKSYWASTLVAFLSEFCGQLSISDISKKTCIHEEDIISTLTQLGLLTYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PKL2</accession>
    <name>A0A162PKL2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_64664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291747.1">
        <property type="nucleotide sequence ID" value="XM_018441332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PKL2"/>
    <dbReference type="GeneID" id="29002238"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64664"/>
    <dbReference type="InParanoid" id="A0A162PKL2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="154" mass="18101" checksum="FA568C297F90AD0F" modified="2016-07-06" version="1">MYCCISWPLAKATIFFGLPLKINGITCTRCIPIKCLFKQKQKKKLSKYCVRKPHGYCTHKHTQLPDQLLDTGHEEEQEDGKYDMSLKFYGFYVLNKFANFYINFKKKKKKAFFWGLVLCLEAVVKNNIFMAVDQCYKLCLHIMLVTVLFLKEFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PS51</accession>
    <name>A0A162PS51_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_169527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290436.1">
        <property type="nucleotide sequence ID" value="XM_018436092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PS51"/>
    <dbReference type="STRING" id="763407.A0A162PS51"/>
    <dbReference type="GeneID" id="28996998"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169527"/>
    <dbReference type="InParanoid" id="A0A162PS51"/>
    <dbReference type="OrthoDB" id="2430203at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="1">
        <location>
            <begin position="232"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="378" mass="43828" checksum="DC34512209C77450" modified="2016-07-06" version="1">MSEVTLTRREQQALRKAALEAVPVRTLRDIGSALEPLTIPNVMKLKSNIVRVFASEWELCKQEIEEQYCVKWIISRPNRHSSTVDITKKKRVLFSQVYSCHRGGSYESESREKHPIQHKSKKVGCCVDDIVAHLTASPDSSARKIRLEILCDIDQQEYSLNVHKINYFDIYNKILADDFKSMKMWFTKKLSPKGFIIFEGNLQTYLNDKSLYACGFTSPFQQSKIKAAATFCMDATYSITQRLDDILYTIVIRDQELDRGFPCAYMLTNDHSLGPIVQWLKHLKDNQLVVNPRQFTINCSDTETNALMTIFPGCQIQYCLFHVSQTWYRQLNLKVKTGNTAAQNHLIRREMMAFLKHNMYEEHIVVILDKIADFIGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T6T9</accession>
    <name>A0A162T6T9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_152167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441001">
        <property type="protein sequence ID" value="OAD66622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284662.1">
        <property type="nucleotide sequence ID" value="XM_018432858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T6T9"/>
    <dbReference type="STRING" id="763407.A0A162T6T9"/>
    <dbReference type="GeneID" id="28993764"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152167"/>
    <dbReference type="InParanoid" id="A0A162T6T9"/>
    <dbReference type="OrthoDB" id="2266637at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="2">
        <location>
            <begin position="254"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD66622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="321" mass="36449" checksum="600FE78B0D2B253C" modified="2016-07-06" version="1">MSSIKLIYEDGQGKIVNEDGSEALSQMIDENSHGLQTISTHSRCLESKNTDILPEVSENGQTDDRAGSPIMPPAKKGKTTRQRNTYSDEDIIRFFKLKDEKLLSANAAAKKLNINPRVAQRWVKKYDEDPDNIFVRGKKSGKRRLTDEHKKCIKEFVAKNASVYVKDVMDHLITIFGEINVSRETVRRFMIDECNLTFKKGVQTSKHLTSTCDKEEAKGVIYVSLRDPKFSKKQPSSGESGKKATAIDHFFMFVKSILGEMDKYPAMEGSFLVMDNAPIHQSAGMSQYIVSREYRSIYLPAYPTELNPIEMFRKVVKDSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T933</accession>
    <name>A0A162T933_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_189622</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441014">
        <property type="protein sequence ID" value="OAD65153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283193.1">
        <property type="nucleotide sequence ID" value="XM_018439689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T933"/>
    <dbReference type="FunCoup" id="A0A162T933">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162T933"/>
    <dbReference type="GeneID" id="29000595"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_189622"/>
    <dbReference type="InParanoid" id="A0A162T933"/>
    <dbReference type="OrthoDB" id="21471at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24139">
        <property type="entry name" value="SIP5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039301">
        <property type="entry name" value="Sip5/DA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315:SF1">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="154"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="86"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="356"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD65153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="468" mass="51201" checksum="BB8D53766C3FFD10" modified="2016-07-06" version="1">MGANTSRESGKSTTQSMHHTHQKIEDLVDLGSILPNGLYPSTEQDFDSRSVRNLIMTRKLAPFYKGLSDAPEPVADSLSVPVPQTSLSLVDSTTRPRSVSNSSRTRSGGPTTTRPRSASSSKRELANVAKERQKLTMERMKQRERMLYNDAVECPICFLYYPSNTNYSRCCDQPICTECFVQIKRPVDTPSTPATCPFCMEENYGVTYEPPAWSDRQSAQQRPLQNNPSTGTRHTTSGGGEGARPRRQCISHTRPEVVLVDHVRPDWQQKLVVPAKTARTVSRRNSASAGPSSRNFLRTAAALTRPGRSASSAASTEHNQYLSNMRDLNMDLEEWMVVEAIRLSLLEETDRAAKAAAEAEAEATAAEATATTTTTTATATATEGLPAGRGEESGTEAVRAPPTTTSESSTSTNPPPVPPSVTIQAHDDDDDDDKPLVQCTQAPVVIVTEDRHERDERQSCDPDSRAIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TAD4</accession>
    <name>A0A162TAD4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_176078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441010">
        <property type="protein sequence ID" value="OAD65483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283523.1">
        <property type="nucleotide sequence ID" value="XM_018437647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TAD4"/>
    <dbReference type="STRING" id="763407.A0A162TAD4"/>
    <dbReference type="GeneID" id="28998553"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176078"/>
    <dbReference type="InParanoid" id="A0A162TAD4"/>
    <dbReference type="OrthoDB" id="2404451at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD65483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="781" mass="89153" checksum="5EF2F95FC8A026B1" modified="2016-07-06" version="1">MSSSNASHQRDRISTQQYQCDQCVLFFDNYQKLQNHKRIHRGDSATMTEIDQSILDDVDMYHDENDTSNEDESSMELDNTISYKCACNFEDSEGEAHIYNSSQISTNTFTKAELMSIHLSQLMLQHRIARAAYRDIVQFINTVIRDHDNIMMEPGAKISHGETVDALLKSKSSVKSHEYDESCVDCGKPQYKTDPNQSQTPAASMKLMSVGDMLSQMLADPATRELLCYRANRESVAGQLTDIFDGDNYKQLVQQGLFSNPDDIAIGLYTDGFVNQKKGKNSYTIIHCIIFSLDPSIRQNGMYFDDISARLRPLEDFKVGNSSKNIYQPSIYTQLSTFSGSSFFALDELHLIARGIGKLVYDLITVTLTKETKFYYTHPDNTLNTTEYPFHIPRADLVTIGNCITSSQKYIPTSFQGSFDNIFAKIDGTHAVDWLDFLLYLVPTLVVPYLPNRAVKTALLSLVKGCALALQWTLTSELLDEMESYFKHWHSFLYQQQQGPLRCYFTRSMERVIGVFLKLIKSKSKGGRNASFLVEQFAIHNYTSMAISICDEINLIWLKLYGRESYMDLPNDPSGAQLWELFHQFVNLNDDLVEGVGGPSVKEALLKYYWRTTGLTGHKFGDSVVVVAARLWMDLTVYSSCMYRRKKNETSRGNHYVMFTCPYRNNRNVIVHSWLISTVQFYFQHVDFYGFPHFLAFVEVMKEHDADGHDSSVPIVKQQSQSTHTLGHQTQPTYAVISVNDICHQVGLVQYPPNGNQFYVIVPYYIFNNNMRITKGNLSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TGH2</accession>
    <name>A0A162TGH2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_151891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD66953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284993.1">
        <property type="nucleotide sequence ID" value="XM_018432776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TGH2"/>
    <dbReference type="GeneID" id="28993682"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151891"/>
    <dbReference type="InParanoid" id="A0A162TGH2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="39867" checksum="303863ED87E54EDE" modified="2016-07-06" version="1">MPSNSSRKTDRKGKGKASASISTSANRVLAGRVGPREIAPSFSSATIQDQQYAEIVEMFNKVNNSINGVKDDIAAVNSNMTAFKNRMGVVVDTSGKTHMAFADFATAYANDQTCMASLGPSLMPSYVPQTSLSDAEISVIISEIFAEKLWDWKFESDDPALVAENESKKKWNLNKKINHCDNVAVINYLKSYISSQTRLAGTHPRVISDKIKNRYKHSHHTFHESPEQKSKKNSKGRANSRTLHYNLYNQMSIQRKLTYMDNWVAIDAAMGYKTGNPVERTYLKLFQKDDMSDGESDIEIFNRLLTMVDYIDRTHHVSNAGVGTKPRMNRYPATLLPCSVPATLSQSLPHWAINDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TK95</accession>
    <name>A0A162TK95_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sec1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_178090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287292.1">
        <property type="nucleotide sequence ID" value="XM_018437952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TK95"/>
    <dbReference type="FunCoup" id="A0A162TK95">
        <property type="interactions" value="972"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TK95"/>
    <dbReference type="GeneID" id="28998858"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_178090"/>
    <dbReference type="InParanoid" id="A0A162TK95"/>
    <dbReference type="OrthoDB" id="10251230at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="645" mass="72349" checksum="58EF2449B6C4B3FE" modified="2016-07-06" version="1">MSIQASDSTSLRAAQYAAVVSMLKLNADTSGSNSFLDDSSNALVLQDDIVWKALVFDKFGQDIISSIMRVNDLRENGVTVHMLLSQDRSPLLDVPAVYFVEPTSENVRKISEDLNRNLYEAFYVNFCSTVPRPVLEEFAGLTLANNTSEKVTQVYDQYLNFVCTNPDVFSLNQPNAFVNLNNPSAPESLIDDTVDRTVNSLFSVIVTMGVIPIIRCPRGNAAEMIANKLDSKLRDHIMNSRTNLFSSSANNSSLQRPVLILLDRSMDLTPMLSHSWTYQALIHDVLSMNLNRITIEADQHNDTRKCYDIESKDFFWNKNASSPFPQVAEDIDIELNKYKKDAAEITRISGVSSIEDVNQLDLPSNTKVLKSAISALPELTARKTTLDMHMNVATCLLNAIKDRQLDTFFQIEENITRQNKSLLLEAIRDPEKKNPEDKMRLFLIYYLSTVDEVSKEDMEQYENALEAAGCELGPLKYIKKVRALMRMTSMLTSAPPTQTGFSQNDLFRGFSSIGNRLTDKLKEGALGGGFENLLSGVKNLLPTRKELVISKIVSDIMTPPQNEPSKADDYLFFDPKLGKNSRSRQKVAFQEAIVFVVGGGNYVEYQNLQEIATQNNQKKKITYGSTDILSPHQFLDQLRTLGNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TLW9</accession>
    <name>A0A162TLW9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_173673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286223.1">
        <property type="nucleotide sequence ID" value="XM_018437083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TLW9"/>
    <dbReference type="GeneID" id="28997989"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_173673"/>
    <dbReference type="InParanoid" id="A0A162TLW9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="115" mass="12471" checksum="BE5B038288FF522C" modified="2016-07-06" version="1">MTPSSLSPHYAAQSPSGRKPDLVAKEVLEWWQTNGKHPFIQPHISSPSNVGANLPENLPLGDKVQLIRLPVASPSAVKEFSQVSSEEPAHLTTGTKGAQKLLRKNPNIFQSGIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TSW6</accession>
    <name>A0A162TSW6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="3 11">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_156127</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3 11"/>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287573.1">
        <property type="nucleotide sequence ID" value="XM_018433466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TSW6"/>
    <dbReference type="STRING" id="763407.A0A162TSW6"/>
    <dbReference type="GeneID" id="28994372"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_156127"/>
    <dbReference type="InParanoid" id="A0A162TSW6"/>
    <dbReference type="OrthoDB" id="3000483at2759"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01679">
        <property type="entry name" value="RNR_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.70.20:FF:000010">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="12">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD69533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="791" mass="89553" checksum="F3FF79850EF65A8F" modified="2016-07-06" version="1">MFVIKRDGRTEKVLFDKITSRISKLCNGLNEEFVMPPKISQKVVSGMYQGITTVELDNLAAETAADMTTTHPDYAILAARIAVSNLHKETHKQFSDVVNQLYNHKHPKTKTDNPLVSQELFDIVNKYSERINAAVDDERDYDLNFFAFKTLERSYLLKVDGRTVERPQHMIMRVALGIHGSDIEAAFETYDFMSQKYFTHATPTLFNAGTPRPQLSSCYLVQMKDDSIEGIYDTLTTCARISKSAGGVGVSFQKIRGSGSYIAGTNGTSNGIVPMLRVYNDTARFVTQGGGKRNGSFAMYLEPWHVDVFDFLDLRKNSGKEEMRARDLFLGLWIPDLFMKRVESNGSWSLFCPNEAKGLYDCYGEEFDRLYTKYENEGRARKTVEAQKLWFAILDSQVETGMPYMLYKDACNQKSNQKNLGTITCSNLCTEIIEYSAPDEVAVCNLASLALPKYVDTETRTFDFEKLHEVAKVVTRNLNKVIDVNYYPVEEARNSNMRHRPIGMGVQGLADAFLLMRYSFDSPEARQLNKDIFETIYHAGLEASCELAAKDGHYATYEGSPVSQGILQHDMWNVSGSDRWDWTGLRAKIAQHGVRNSLLVAPMPTASTSQILGNNECFEPYTSNIYTRRVMSGEFQVVNQHLLRDLIERGLWNDQVKNMIIAHNGSVQQVPTIPEDIKKLYKTVWELSQRVIIDMAADRAAFIDQSQSMNLFAAEPTFGKLTSMHFYAWKKGLKTGMYYLRSRPAVDAIKFTVDQLALKDMSAEERKIQEEKLVAMQCSLDNKDACISCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U3A2</accession>
    <name>A0A162U3A2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_187479</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290073.1">
        <property type="nucleotide sequence ID" value="XM_018439387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U3A2"/>
    <dbReference type="STRING" id="763407.A0A162U3A2"/>
    <dbReference type="GeneID" id="29000293"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_187479"/>
    <dbReference type="InParanoid" id="A0A162U3A2"/>
    <dbReference type="OrthoDB" id="43122at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700">
        <property type="entry name" value="YALI0E22418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="3">
        <location>
            <begin position="204"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="256"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="654"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD72033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="727" mass="79605" checksum="D7732AF3EC765376" modified="2016-07-06" version="1">MSSDLDTILRDLEKQVHDFSLTMDPPIPINTHIRRSPSSRLTNPDKGSNPNRPLQSAHTMHVPPITQARLNRPDFSPSLSEDEDKGQFYSTNDANDSSDDDVCIANLQSVTRAQDDKSKGMTRSRSTRANRGGMAGGLVRSASASSRTYKPPAPEESAPPLPIRDTDEDLNLVIQRAWALYEQGPYDEPVAVESAPSVLPETYLRKKGLIDMSEGWALFEIANSHGVERPLREWELVLEVVECWGPDANNALLVKKYAYHNSLTAEGKWQKRFCYIKDNAIHHAKDTKGNGSAILCYLATFDVYTLLPQQSRSAPSGYVFALRAQDKDSIFEREEDYMRLLAVEDQEAMKDWVLSIRCTKSLIDHQYHPQRVINPLAPIQAPVQASYDHQWSATDNSVKPADPVDAGSPRLRRALTSRTPDCKSDQSGDEGYGTTSFLRRQKSTRDVKPATLVDEHTKHQQTSSSGLHRSESSRRIDEKRGRGLSRGLSRSTTMRGREEGGLGSAIPDSPLIDYTEPSTFAKGSLLGKDGEEHTTGRLQDDAHAASVAAANNTLIQINDKVKFSKGSLLERNESTHAKIGRSKSTREHHAPPSSSSVSSAAAAASSSVATASASASSAADTQPTNELRQHMSLRRKLTSSKDRERSRHHENLAPTMPSSSPSSSNVSATASPVLGATVSGGIAPSATSHGPLLQLDGTPEQIHTKKLLGRQMKPLLNFADSDDKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U489</accession>
    <name>A0A162U489_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_80015</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290263.1">
        <property type="nucleotide sequence ID" value="XM_018443537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U489"/>
    <dbReference type="FunCoup" id="A0A162U489">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162U489"/>
    <dbReference type="GeneID" id="29004442"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_80015"/>
    <dbReference type="InParanoid" id="A0A162U489"/>
    <dbReference type="OrthoDB" id="435980at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF15">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="6">
        <location>
            <begin position="110"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="6">
        <location>
            <begin position="273"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="7">
        <location>
            <begin position="375"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD72223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="454" mass="49419" checksum="6F5BAC5793B15460" modified="2016-07-06" version="1">MESTRFVVLRGSEACYSIVRQRTKAGLWSSVRSLHNIRQASLSNRETHFILTNNESLRRTRTPRYTLYKRELRLHGTHNHSHGGAHDHVHVDLGTTIRNSGKQGVRITVIGMAANVGLTVSKGLAGWMMNSASLLADAAHSFSDLLSDFVTLYTFKMSRKEPDAIYPYGYGKYETVGTLAVSSLLIAGAFGIGIHSFELLMAALNVSGVDLVTQGASVAATATAEANSGTDILSNTTTANANVNTSTNTSSSLSHGHSHGHFYSNDGVLDPNAAWFALASVITKEWLYRATIKVGEKERSDVLVANAWHHRSDAYSSVVALVAIGGSWAGLPVLDPLGGLLVAGMIFQSGGSLMRSSLRELTDKGIGPAEITDILSAINKVKEQEQDLIDFHSIRGRKMGPFHHLDLVLQLNPQLTISQAHRIEQLVRHTIKTECKLIQEVLVHLDAEKQPPHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U6D2</accession>
    <name>A0A162U6D2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PHYBLDRAFT_124787</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Cytoplasmic vesicle</location>
            <location evidence="1 14">COPII-coated vesicle membrane</location>
            <topology evidence="1 14">Peripheral membrane protein</topology>
            <orientation evidence="1 14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 14">Endoplasmic reticulum membrane</location>
            <topology evidence="2 14">Peripheral membrane protein</topology>
            <orientation evidence="2 14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Golgi apparatus membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291832.1">
        <property type="nucleotide sequence ID" value="XM_018429009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U6D2"/>
    <dbReference type="FunCoup" id="A0A162U6D2">
        <property type="interactions" value="482"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162U6D2"/>
    <dbReference type="GeneID" id="28989915"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_124787"/>
    <dbReference type="InParanoid" id="A0A162U6D2"/>
    <dbReference type="OrthoDB" id="10256289at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01478">
        <property type="entry name" value="Sec23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11287">
        <property type="entry name" value="Sec23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.730:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1670:FF:000006">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000006">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000008">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037550">
        <property type="entry name" value="Sec23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="16">
        <location>
            <begin position="55"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="17">
        <location>
            <begin position="123"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="19">
        <location>
            <begin position="401"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="18">
        <location>
            <begin position="516"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="15">
        <location>
            <begin position="628"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OAD73792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="763" mass="85721" checksum="6B314FF723ECC474" modified="2016-07-06" version="1">MNFDEIEEQDGIRFSWNAWPSSRIEATKAVVPIACLYTPLKEREDFVETPIWYEPVTCKAPCRAVLNPYCQIDFRSKVWVCPFCLQRNPFPHHYKDLSNTNLPAELLPKYTTIEYNLNRVAQVPPIFFFVVDTCLEQEDLDALKSTIIASLSLLPPYAWVGLITFGTMTQVHELGFASCPKSFVFRGTKEFTGKQIQDMLGLSGGTVRPGLPHGAPGKTPAMTAPANRFFVPIKDCEFVLTSILENLQKDPWPVTLNKRPERCTGVALSVAIGLLEASFPNTGARVMLFSGGPATEGPGMVVSTELREPIRSHNEIEKETARHYKRAVKFYESLSKRATANGHTIDIFAGCLDQIGLLEMKSMVNTTGGFMILSDSFNAAIFKQSFHHLFQKDSQGHLQMGFNATLDVQTSRELKVSGLIGHATSGNKKSTYVGETEIGIGNTSSWKICSITPKTTHGIYFEVVNQPNAQFQPGSRGLIQFSTHYQHSSGQFRLRVTTIARNFAEGQSPETANSFDQETAAVLMSRIAVFKGEIDDGPDVLRWLDRMLIRLCQRFADYRKDDPHSFRLSENLSIYPQFMFHLRRSQFLQVFNNSPDETAFYRHALNRENVDNSLIMIQPTLTSYGFDIPPQPVLLDSVSIKPDCILLLDTFFHLLIFHGETIAQWRLAGYQDQEGYENFKQLLEAPILDAQDLLIDRFPVPRYIVCDQGGSQARFLLSKLNPSTTHKSNTPYGTPQGTAIFTEDVSLQQFMEHLKKLAVSGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U6P2</accession>
    <name>A0A162U6P2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_65297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290823.1">
        <property type="nucleotide sequence ID" value="XM_018441432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U6P2"/>
    <dbReference type="STRING" id="763407.A0A162U6P2"/>
    <dbReference type="GeneID" id="29002338"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65297"/>
    <dbReference type="InParanoid" id="A0A162U6P2"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007840057" description="BTB domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="1205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1205" mass="137766" checksum="4AE2D4616B8528EE" modified="2016-07-06" version="1">MSLYFYLCTLLFRISFLLIYEDQHDIINIATDNPTINLSSIYKDIRSTDPVIRLAIQTKIRDLPLIQLDNLLRQWIGHALRQTQRWPIHRLLRCIDIIIQSIDQNEKHVLRLPSLHKSIQQVLVVTHTSPSDVTAQAFLPCFTKLFERFSRLLPRKECQSAVGNLIKWCMESEKSIRLICLRGLLKPCFQKTLVQCDAYWLLTQQLHTIQTERDELTLVSRLLEQLIKYGRDAPIGKHAHTQLVNFSNAAHFHILVGVWENVSKTYQEQPLDIRPIHSLTTIVNICCHVSEKAVERISERKSIEKWQPLMYQAMRDFLIQSSALKQSLYGQMSEAEQSKETPWPKPEPSSKYKNETDISASLLSRILQCNSRVFPASQKIKTPLAINQCVLAIIQCLTVYISWPITPEDISQVGQENWTTNLYIDAETRAFCCVDAGLLLLYEPLFVILLDGLIQIVPHIPTHQVAQISRSIAVCIQAIWTSLLRSNRESPQISSRLEKLTIFLLHYNNAIDQFANASSSLQPLIWRPTLDQAKQCLMAMTSQKPTEWAPNVIDKAKRALISLEKATHHARACERLVSEDALSLVSPELVPDESRTGASTDSLTIYALLVRFISSLVNKTAYVRIRLREEQTLMPMIFHLLTIGVQEREKSISQRKEWNRLLFWSIDVIRAFKFDHVSLRAWITWTDQKLAKMNISTATATYKPSLCTILKLILTPFQQTSIYPSMDIWSSDEEVIITAIFLMDQLIVLPDFGKQIMETPGFLECLSKLLITVCCPVTGRSRRMAIDEIVNPDLMEYKSSEYTTELPKSIDRHGISSPYIQVLQKTITRLLTTKENIMVILNQYLLTSFFNPMLRTMSTQGTYWQDFFSEQIYERIYDDLQRIFLFTADDNNAIILHESTAIAISYACMDPSHWGLLSEEHSGGILYTNSVLGVICHMLVYDLEHTQTDYAMERYIIGRKVAAAQVLETMGTKAAQFWYRSPFQWPGKRDIETNTTSTPVLFITDDSDELVESTSDVLIPQSSSFTALLSNIYSESTVKPIRLHDVSCSGLRLLFSLLSRLKTRPTLSDAALLPQSISWPDVIELLKLADRFGCYDALYVCEQWILDQVKHRVVTNECLEGCVMLFRACRDPTANDGGITSNVWPFQQVVQICVQGLISHCVRMVSLKSFKSMVEDNDSDELSAFCDSIVITLKFGVIPRDDTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UJK4</accession>
    <name>A0A162UJK4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_77270</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294712.1">
        <property type="nucleotide sequence ID" value="XM_018443241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UJK4"/>
    <dbReference type="FunCoup" id="A0A162UJK4">
        <property type="interactions" value="1142"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UJK4"/>
    <dbReference type="GeneID" id="29004147"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_77270"/>
    <dbReference type="InParanoid" id="A0A162UJK4"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16657">
        <property type="entry name" value="RING-Ubox_UBE4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.140">
        <property type="entry name" value="PDCD5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036883">
        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="13">
        <location>
            <begin position="1012"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="29"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1071"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="551"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD76672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1098" mass="125550" checksum="8157506B7A593018" modified="2016-07-06" version="1">MYMTSRNLSRKAHSCLTLSIRLKRVAKLQQQAEEQRKKQQQQQQQQQQQASEKRATASPLQPLPSIEPEIYKRPVKVPVSAASTSSAPIQKPTSPAPTPVQPTVTKPISSPKTFEDWQNDVLSRILQVTLDSEAIHKQGGCIYLEGMVAELEEEEEPKPFKLSQALMDRILVARLSLDPNETYPNLPQNVQQDLKISHFDYLLNCWKRAQDIKRNTLTRSKNLEKTVLDKRLSVLDSVKLLLVSYSGLVLQIPDMFPQIETQQPLGPSQLVSRLLAQPDTAQGLPTEYLSELINRFTDDGLDTILGTPLAMISDQVRRISILDNFKPFIQSLSFLCENKSVPTVLPTLPEFDPETATARTIEELSLLGPYFKLSAYPGSAPKVAESLFQNAESRNSGDIESCKNGVRGTIQNIQRSLFGISSSIVRASTTSREGLLVYFSHIIRLNQKRAQIQVDPQTVATDGFMHNLAAIMLAFSDPFLDVGASKVDKIDTSYFRTSKRIDIKEDTKINATEEQSDAYYNAAIPNKSHNFITEAFYITLAAMHYGPIRSLVNYNELIREYNEAKKHHERAQQDAVRLTNNTQRVMQDFVAKRLKANLETMTMHKLAYESMVLDPEFLTQTMRFYNLVMAWMVRMVDPVHQHPWNPIKLPLPKDIPDTFSMLPEWIVEDIVEFFIFVGKFGYDTQVIKMNPQTELVTFIITFLRNTKYIKNPYLKAKFVEILFFYTYPIAKGVPGELEAMLNSHPLALEHLVPSLMTFYVEVEQTGASSQFYDKFNIRYNISHVMKTIWSHPAHRAKLREESRNTDVFTRFVNMLMSDVTYLLDESLSKLAEIHQIQTEMEDSATWDAQPDQQRQEREGQFRSLERQAQSYVSLGNETVNMLTYLTAEVVEPFLVNEIVDRLAAMLDYNLSQLVGPKCTGLNVKNRKKYHFEPRALLSQIIDIYLNLNSQTFIEAIARDGRSYRKEYFSKAASILLKHGLKQTDDIAALELIVRKVEEAVRSGAEEEEELGDVPDEYLDPLFFTLMEDPVVLPTSGVIVDRSTIRAHLLGDTRDPFNRTPLSMDMVQPATELKEQIQRWKEEQKQKREDEKNKMDTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162US15</accession>
    <name>A0A162US15_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_141380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295533.1">
        <property type="nucleotide sequence ID" value="XM_018430581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162US15"/>
    <dbReference type="GeneID" id="28991487"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141380"/>
    <dbReference type="InParanoid" id="A0A162US15"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="66" mass="7342" checksum="F73F867299517A9E" modified="2016-07-06" version="1">MIDMCLVDLLSWSWENVLHSTINIANQSKLMNLVLPNTVLSVPSLSLKPSSKSRTLAHIAALKRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UW63</accession>
    <name>A0A162UW63_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_140478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296423.1">
        <property type="nucleotide sequence ID" value="XM_018430407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UW63"/>
    <dbReference type="FunCoup" id="A0A162UW63">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="GeneID" id="28991313"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_140478"/>
    <dbReference type="InParanoid" id="A0A162UW63"/>
    <dbReference type="OrthoDB" id="6019893at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF21">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03455">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="193"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="659"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="699"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="756"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD78383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1072" mass="119899" checksum="A9D38C316C0FD8B1" modified="2016-07-06" version="1">MAASLVPVTRLADYFFVAGLHDDKLISTYEDAKKGEPTGADDVYYDQQKQAAATDTNPAFLSSSPPPQAHVRPRGMSSPLEYNDPNDSFYDVLDHVQSVIDTFGKDRDSARDVIAVKKGATHRSETAPIVSRHSSGVRRQSARQRSLRYSKTWRSISEANTKGDTGSTRPRSVSLHQNAISSPEQEPVPKPTETSKPIIPNLLEIKYIPNVLSRYPKQDYSVNEQFPAYVAMFCFPKDISLHYGKDPPAEQTHSFAMTDENGRSIYGTCVVFYEPLSPKLYDPVNKAIQEWIQVNMSASTIEYAQHLQGKINDEQHQLEEHGAMLATLATLTTTPEVQAEREILEEKVRTSQENLALYSELLVPVRMGICEAKHIWVPKCVGVLGGMPWMDLLGDWIRILVDAVVGVRGHKHENSAINIEREVPLPSPGRFETRLVIHHRSLFFSRPAINQVPVLKNFSLFPLFRALSPHLILVVIETLLSEGKVLFLSKCAGMLSLAAESFRYLLFPFYWQFVFIPVLPEKLLTCLQAPVPYIIGYQGEIDELDEHLPDDVCIVNLDTNTMHQSQPPMPLPTRARRKLQSSLEQYAPLHTRFKVPYGVPLPVLETFPNGRLLLNCGRSKTQDVFVSPAQRRDSESSDGYSLMSHPASTNSKPISGFWSSNNSTRSSNDSVTSLPLGIDMPAPSLPQFPNFAKLAITTQSSTSSPAPHSSVVSSPQLAPQRSTPSPSRSSLPTQGVSNPQKEAGEDNRRSGPPQFKSKNNNQNSNSNQTKYAESIQEGNGIRRLSALMSKPRAVFQQTHHETSEPPSAYASPHLLVPKELEAFGNLDGTQQQNHEVLRRVKHIEGHTMVEMLHHELSNFHGHRCVCGQQVGEEGMGVLQRQPVFMYCQDCHLVTHAVCTSQILHPCLPACFDEAKIQASFLRMFASLLCNYRSGIVDGVQEHGGNGFAASFAEYSVDKNGVLFFSKDKFLKQSDKDTRIFLSNLANSQMFNQFITDRLAKSSKDPEILVFDEYIKLKLNRSKLKFVKESTPFLNDDSYRVSQTVRASSPDDIRHGCLYTGKRFPIHLQIMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UY53</accession>
    <name>A0A162UY53_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_179677</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296782.1">
        <property type="nucleotide sequence ID" value="XM_018438191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UY53"/>
    <dbReference type="FunCoup" id="A0A162UY53">
        <property type="interactions" value="899"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UY53"/>
    <dbReference type="GeneID" id="28999097"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179677"/>
    <dbReference type="InParanoid" id="A0A162UY53"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03751">
        <property type="entry name" value="proteasome_alpha_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000007">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD78742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="249" mass="27660" checksum="01D396AA94D581D9" modified="2016-07-06" version="1">MTSIGTGYDLSVSTYSPDGRVFQVEYANKAVDNSGTAIGLRVKDGVVLAVEKLVQSKLLVANANRRIQSADLHIGVATAGLLADGRHLVNRARDEAQSWRDIYRQPIPGKALADRLGQYVSAYTLYSSVRPFGCGTIVGSMTEGEPSLYLIEPSGVYWGYRGCAVGKGKSVAKTEIEKLKMEEMTVREAVNEITRIIYTCHDEAKDKDFELELSWICPESKYKHQFVPKEIKEEAERLAKESLDDEMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V0R2</accession>
    <name>A0A162V0R2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_139259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297263.1">
        <property type="nucleotide sequence ID" value="XM_018430190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V0R2"/>
    <dbReference type="FunCoup" id="A0A162V0R2">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162V0R2"/>
    <dbReference type="GeneID" id="28991096"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139259"/>
    <dbReference type="InParanoid" id="A0A162V0R2"/>
    <dbReference type="OrthoDB" id="529194at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20267">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045298">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD79223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="88" mass="9743" checksum="4905C51352427B11" modified="2016-07-06" version="1">MVNPVTPSRLAAISAYRNLLKTQRDVFKNDNGAIQARVAAKKETHARFMQYKEETNCDKLALAEQVVSLLKKNVSLAELKNEGGIGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V1S3</accession>
    <name>A0A162V1S3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF866-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_139441</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297452.1">
        <property type="nucleotide sequence ID" value="XM_018430226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V1S3"/>
    <dbReference type="FunCoup" id="A0A162V1S3">
        <property type="interactions" value="324"/>
    </dbReference>
    <dbReference type="GeneID" id="28991132"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139441"/>
    <dbReference type="InParanoid" id="A0A162V1S3"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD79412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="18352" checksum="639A90AD7C377ED3" modified="2016-07-06" version="1">MVKLGLYLKADLENVTELVPVEDYEWHFKVECGSCREVDESWITFNRQDSYDMSGSRGTANLVMRCKFCKRESTAQFETNGKVVPYTKSGEFQKIATFDCRGLELVDFSPRESWVAKGIESDTKFEDIDLLEGEWAEYDDKSNEPVGISDIEIKFKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V266</accession>
    <name>A0A162V266_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_139507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297512.1">
        <property type="nucleotide sequence ID" value="XM_018430238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V266"/>
    <dbReference type="GeneID" id="28991144"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139507"/>
    <dbReference type="InParanoid" id="A0A162V266"/>
    <dbReference type="OrthoDB" id="2283980at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD79472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="65" mass="7543" checksum="7F93FA6FAF6121E7" modified="2016-07-06" version="1">MTLDKFKYGLEFDTRQFSAENYKRFAEAIYKKNNVYSPIIGFVDGTMQKIACPNVNYEQSLAYNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WIF8</accession>
    <name>A0A162WIF8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitin synthase export chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_30282</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CHS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285385.1">
        <property type="nucleotide sequence ID" value="XM_018439961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WIF8"/>
    <dbReference type="STRING" id="763407.A0A162WIF8"/>
    <dbReference type="GeneID" id="29000867"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_30282"/>
    <dbReference type="InParanoid" id="A0A162WIF8"/>
    <dbReference type="OrthoDB" id="2189463at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF2">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD67345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="335" mass="37871" checksum="B9550DD528856E42" modified="2016-07-06" version="1">MVTITYRFDAFSFDGICQTIALSVCPLIGQAEGIEPVCYSRNVDLGGNLIFQPATLIIDCVAIIMTAIMIYHIRSKYTAVGRKEIVMFFYLYMLTIFIEMLLVTGIIPTSSPVYPWFTAVHVGLISATFWCLLLNGFVGFQFAEDGTPLSLWSIRISSLLYFILVGAIAICTFKNIGPFSYTSPGALWVFYFIINGIAFLVYVVSQIVLVVNTLDDRWPLGDILFGTAFFIIGQVLMHVFSVVICDEVKHYVDGLFFGTICSLLAVMMVYKYWDSITKEDLEFSVGSKQNVWEVKELLGEDELAQNYSAGYAQQNQQSQPQQYGQQYQQYEQHPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WKU8</accession>
    <name>A0A162WKU8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_136269</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286725.1">
        <property type="nucleotide sequence ID" value="XM_018429773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WKU8"/>
    <dbReference type="FunCoup" id="A0A162WKU8">
        <property type="interactions" value="349"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162WKU8"/>
    <dbReference type="GeneID" id="28990679"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_136269"/>
    <dbReference type="InParanoid" id="A0A162WKU8"/>
    <dbReference type="OrthoDB" id="10249382at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000004">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000003">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000012">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="10">
        <location>
            <begin position="48"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="11">
        <location>
            <begin position="249"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD68685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="459" mass="51357" checksum="90F6D4F653F50833" modified="2016-07-06" version="1">MPREIITLQAGQCGNQIGSEFWRQLCAEHGISSDGTLEKFATEGGDRKDVFFYQADDEHYIPRAILLDLEPRVINTIRESAFANLYNPENIYVSKNGGGAGNIWSSGYAQGETVSEDIIDMVDREADGSDSLEGFMFLHSIAGGTGSGLGSFLLERLNDRYPKKLIQTYSVFPNAEEVSDVVVQPYNSMLTLKRLVHNADSVIVLDNSALARIATDSLHIKNPTFEQTNQLVSTVMSASTTTLRYPGYMNNNLVGMIASLIPTPRCHFLTTAYTPFSSEQVEEAQSVRKTSVLDVMRRLLQPKNRMVSTVPSKTSCYISVLNIIQGEADPTDVHKSLLRIRDSRIAPFIPWGPASIQVALSKKSPYIQTPHRVSGLMLANHTGITSLLQRTCDQFDRLMRRNAFLESYRKDAIFSDDLDEFSDSREVVRDLVDEYKACETPDYVNYGSKKAQKRNDMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WMI4</accession>
    <name>A0A162WMI4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_67168</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD69075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287115.1">
        <property type="nucleotide sequence ID" value="XM_018441747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WMI4"/>
    <dbReference type="FunCoup" id="A0A162WMI4">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162WMI4"/>
    <dbReference type="GeneID" id="29002653"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_67168"/>
    <dbReference type="InParanoid" id="A0A162WMI4"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="102"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD69075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="388" mass="43786" checksum="CB57BD55DB5C4FFF" modified="2016-07-06" version="1">MESLRALVKSTLLNAVPIPIVLKSMRLILALPPSVAQRLVADYTTPTQQEENWICRIKQDTWTGAWIAPGLGECNQQEVLERVKAADLIIYEVHGGGFRIGLAPLHKYPTQIHECMDAYRYLLEELNVPASKIVLAGDSAGGALCMETLMRFYAPNVINDINSPREYMKATLPAGMALFSPLVSGDKDNWLWEANKHDIVSPQLAELVFKEYLDFPNKTKEEIPSFRLYGITSGFDRFFPKNVSVYVGEQEVMRDDILGTASRIMEDSKFNVDIHREDLVHDWYFVQEIVPQEDRHLFEKYDHTFVDFMAKSIKEARETIEVTSQNADCLVSQAEIAQITSKLLFESSVLDPNIGLVEEDEKIAMIQNDTQLDAVQAALYATPQPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WSP3</accession>
    <name>A0A162WSP3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Ubiquitin-activating enzyme E1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHYBLDRAFT_135242</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 9">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288745.1">
        <property type="nucleotide sequence ID" value="XM_018429706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WSP3"/>
    <dbReference type="FunCoup" id="A0A162WSP3">
        <property type="interactions" value="1335"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162WSP3"/>
    <dbReference type="GeneID" id="28990612"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_135242"/>
    <dbReference type="InParanoid" id="A0A162WSP3"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000618">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000004">
        <property type="entry name" value="Ubiquitin-activating enzyme E1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030661">
        <property type="entry name" value="Uba2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF5">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039133">
        <property type="entry name" value="SUMO_E1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6 9 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="14">
        <location>
            <begin position="10"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-activating enzyme SCCH" evidence="15">
        <location>
            <begin position="290"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10 13">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="28"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="60"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="121"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR039133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF10585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAD70705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="531" mass="59079" checksum="C674C11D677D5BB8" modified="2016-07-06" version="1">MPRDSHLKKILGSSTYNTVASSNVLLIGAGGIGCEVLKNLVLMGFKNISVVDLDTIEISNLNRQFLFQKEHVGQPKAHVAREAVLKFQPKANITSHHANIKDSQFGIEWFKQFSFVLNALDNLDARYYVNKMCLAAEIPLVESGTSGYKGQSYIIKKGVTECFSCSPKPTPTTYPVCTIRSTPNAPIHCIVWAKNFLFCQLFGDAELSDAIKEDASDDNGKYYLSELKREANDLKEIKNAMGTEEYTRLVFTKVFTTDIQRLLDANISRGGRKPPCPLDYETLDKQAKDPKQTVENEDGQETLADRKVWSLPECFHVFKESANNLALQLIAQQANDPNAMLSFDKDDDVAMDFVTSASNLRAYVFDIEQKCLFDVKSMAGNIIPAIATTNAIIGGEVVMNAYRILNNKIEKSKRNYVDTQVANGSAFMNEEISKPNPECDVCKSKNVPIQVSKESATLGDIIDSIILKPVEDGGVGFDEEFLIMDGNKLIYDPDYDDNKNLLLKELGIQDSSILRVSPDEGQPLDLIVQFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WVD7</accession>
    <name>A0A162WVD7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_148293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD71075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289115.1">
        <property type="nucleotide sequence ID" value="XM_018432064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WVD7"/>
    <dbReference type="GeneID" id="28992970"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148293"/>
    <dbReference type="InParanoid" id="A0A162WVD7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="89" mass="9644" checksum="7CA4D4ECD6B6C5AE" modified="2016-07-06" version="1">MFLVEVSGVGFPKKPWGTTLVPRDTSLGRLTIDVNAHESGTTHHGSPPDQTTKGIHCPVSITRNWLTLFLLTTHVTISRAAAIAQLGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WXG7</accession>
    <name>A0A162WXG7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DC-UbP/UBTD2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_95130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289405.1">
        <property type="nucleotide sequence ID" value="XM_018443883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WXG7"/>
    <dbReference type="STRING" id="763407.A0A162WXG7"/>
    <dbReference type="GeneID" id="29004788"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_95130"/>
    <dbReference type="InParanoid" id="A0A162WXG7"/>
    <dbReference type="OrthoDB" id="1640476at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.225.20">
        <property type="entry name" value="Ub domain-containing protein, DC-UbP/UBTD2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032752">
        <property type="entry name" value="DC-UbP/UBTD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038169">
        <property type="entry name" value="DC-UbP/UBTD2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039869">
        <property type="entry name" value="UBTD1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13609">
        <property type="entry name" value="UBIQUITIN DOMAIN CONTAINING 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16455">
        <property type="entry name" value="UBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DC-UbP/UBTD2 N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="98" mass="11089" checksum="B257FEE97096A7A8" modified="2016-07-06" version="1" fragment="single">PFKRAQLTWVAEEPITRTQLDRQRTAFWETAPSYEGRREIWQALQAACTTPDLHLARSILDAANVTLPTGNPAEGCFDELGNRYEIPLYCIVNPSNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WY90</accession>
    <name>A0A162WY90_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_91272</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289545.1">
        <property type="nucleotide sequence ID" value="XM_018443766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WY90"/>
    <dbReference type="STRING" id="763407.A0A162WY90"/>
    <dbReference type="GeneID" id="29004671"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_91272"/>
    <dbReference type="InParanoid" id="A0A162WY90"/>
    <dbReference type="OrthoDB" id="2573163at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF21">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD71505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="196" mass="22675" checksum="11A5DC6534EFBFB2" modified="2016-07-06" version="1" fragment="single">QYILIEDLTDGVQKPCVLDLKMGTRQYGVYATRDKMRSQTLKCESSTSKTLGVRVCGMQVYNQPSQSFKFQDKYFGRSLKTANQFRDALERYLDNGQGCQIHHIPFVIRRLIALAKIVKQLVDYRFYASSLLMIYDGQNPQRPMDLRIIDFARCVSAEDVRLHSEEFTFPPRHKGPDNGYLLGLKTLVVCFELIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162X347</accession>
    <name>A0A162X347_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phox-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_113625</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential for proper morphogenesis of the vacuole. May exist as structural reinforcement on the surface of the vacuolar membrane and be required for maintenance against rupture by osmotic pressure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290335.1">
        <property type="nucleotide sequence ID" value="XM_018428349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162X347"/>
    <dbReference type="FunCoup" id="A0A162X347">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162X347"/>
    <dbReference type="GeneID" id="28989255"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_113625"/>
    <dbReference type="InParanoid" id="A0A162X347"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097576">
        <property type="term" value="P:vacuole fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06897">
        <property type="entry name" value="PX_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15858">
        <property type="entry name" value="SNARE_VAM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000058">
        <property type="entry name" value="VAM7p Vacuolar SNARE protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="PX" evidence="7">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="6">
        <location>
            <begin position="282"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD72295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="39866" checksum="70723DCBD3251A32" modified="2016-07-06" version="1">MTEHIQAIFIRESETRSQPKPHTVYKIEVHAAVRNWIVWKRYSEFAKLNSRFLTIFPKNRPPVPLPSKHIFPSTFSDPDRIEDRRRGLEDYLRGMLSSRDDRWRQTELWKEFLAIPTGRQLDGQAHYTSESWLDEYNAMNSTAREIRSLINKRATHMGRDEISASHNCTMQAKKLLITLSSRTSALESGLTGLANGSFFQGLMSDGELRRRQDMLSTLKDERDTLMRLVNTGRQEQELLYNKPTSQSPTAALQQQKQQQQQRAKETEWTRGLDNGGLLTQQQQLMEDQDQQVEQFSSILSRQRQLGIAIGDELETQSQILDELDGDVGRTQTKLKFASKKLGKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XHM3</accession>
    <name>A0A162XHM3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_144287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292975.1">
        <property type="nucleotide sequence ID" value="XM_018431185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XHM3"/>
    <dbReference type="STRING" id="763407.A0A162XHM3"/>
    <dbReference type="GeneID" id="28992091"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144287"/>
    <dbReference type="InParanoid" id="A0A162XHM3"/>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45296">
        <property type="entry name" value="TRANSDUCIN/WD40 REPEAT-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45296:SF1">
        <property type="entry name" value="TRANSDUCIN_WD40 REPEAT-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="246"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="336" mass="37127" checksum="EB3DCFD165914886" modified="2016-07-06" version="1">MSTIPLTPIVKLDGHKAPPDHSILIYHNRAHVVVYYIEDNTCRIWDLRSSRVVKGIQNLNSPVSSISFAPQSSCPYIYLSSGTKVYTFDLRNTDMILAEPAREYNFSADEINAIDVNEKNTFLATADDDVDLSTHKIHKSFSKKHNSIAMAVKFRPKKPWQVWSGGLDSKVFQWDFSRGMITETFDMNPSEPTAAQMFNPPFVYSLAVSKDGQIIAAGLGDSTVQLISCNTKKRLKNGVPTITRLENGHKSMVNSLTFLPSTRTKLVSGSANGSLALWEWSELEGEQSPTLGQTFQLDNGFVKLNWVESFDVGDVRLAAAGVGKAEAGALAIYSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XK91</accession>
    <name>A0A162XK91_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_186402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293475.1">
        <property type="nucleotide sequence ID" value="XM_018439236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XK91"/>
    <dbReference type="GeneID" id="29000142"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_186402"/>
    <dbReference type="InParanoid" id="A0A162XK91"/>
    <dbReference type="OrthoDB" id="2280271at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF72">
        <property type="entry name" value="IM:7136021-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="596" mass="68553" checksum="71A70D97A4F2AB9B" modified="2016-07-06" version="1">MIEKLPLEILLIIADLLEARDKKTCSLVCRLWKDIFQKNLWKVVKISRSSWVDSLERGVSKYTLKENHNRVHSIEINNYMCRTNSAICKLINLFPGVKYFSYSASRGRIWSLSMTNLSGWKSLTHLSLKFGLRNIPTITEELFKSLSVLPALVNLTINQKPPFSSNTFITWRHIDQLHSHLPRLKYLKCQMNLQKINPSEITELRNIKPAENLRTADYSAPRLDMQWIIYLALKYPKLVTLYLTVEKRRDLSERAARTSKSTKGLEFSALYSQLFKSGVKLEKIETSLFTNPPGTKLPANQTACAQLFSATLKSLQVGRCYKEHSNLKYSLTDLGTVEFSSLVYLNILCARMFLKIDNVLNVCPSLKKLEITSPSIDVNNQKTTSTFKHGLRHLRLVNTTIKPLCFEYISDSCRQLKYLSLKDVEIRNPDSENNTCLYLNMPFTQLMTLSLSNVRLCNYPSFIFSSQYGRKFNDSAQNEQVCFTEVYLNYSRNVRSYSYIVSDHLLEEWNRIQKIAIITPNDVLGYTEALNKQNNGISIMNSNCAGPSNEIFKSGDCFKTNVEFFCIVFQCKAIKQTIINDRSSYGCSTPIFRFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XP23</accession>
    <name>A0A162XP23_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_165880</name>
        <name evidence="4" type="ORF">PHYBLDRAFT_165882</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293942.1">
        <property type="nucleotide sequence ID" value="XM_018435320.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293945.1">
        <property type="nucleotide sequence ID" value="XM_018435321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XP23"/>
    <dbReference type="GeneID" id="28996226"/>
    <dbReference type="GeneID" id="28996227"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165880"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165882"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008241044" evidence="2">
        <location>
            <begin position="24"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD75902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD75905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="182" mass="20935" checksum="103337606FC02E46" modified="2016-07-06" version="1">MFFGTTILHLRVVLLYLCSLSLGLTHCYCHPFLALFMNSSESEAEGKGEICDNFISRNVNKESQNIERMYGPGTLCPISPPFPVSLYHLCPPEVVPMRTDLVWYRCIVRFHKWIVRVSKRNISLEFLSLLKSVPNPGVFSTQLLILNSFMPFIFSYIFIPSVFLPVVLFILILDFFKAVFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y997</accession>
    <name>A0A162Y997_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_58184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297175.1">
        <property type="nucleotide sequence ID" value="XM_018440273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y997"/>
    <dbReference type="GeneID" id="29001179"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_58184"/>
    <dbReference type="InParanoid" id="A0A162Y997"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="239" mass="27433" checksum="9E7B0D7F30E5ADD8" modified="2016-07-06" version="1">MFGQTSLISSSASSVPSKRSRSYSQESITISTSSSANCAVSFMDVDSGNCSFGECNISFCAREEEDEDDIEILLDPSQLDMEDQFIFEIVTGYGQRKPSCYSVIHLFYMILLRNFILLKANVSTKDLKVDVNLGVVYLDEGTKNPVKTCTFVGGIQKLTKLKLYNDAKIHFFHIVLCCLSTYCSSYGGMKDIKKSRIYANWLLEMLLKYRSTEYQSYYYVKYFYLMLLKYFIMKITYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YCN3</accession>
    <name>A0A162YCN3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_157338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297835.1">
        <property type="nucleotide sequence ID" value="XM_018433603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YCN3"/>
    <dbReference type="GeneID" id="28994509"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157338"/>
    <dbReference type="InParanoid" id="A0A162YCN3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="51" mass="5963" checksum="011DD65BDF3669E8" modified="2016-07-06" version="1">MEENDRKQQAATKCNFYKKKNHCPRSQSCSAQQQQQHTRPFTEAIGKNFCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YDM4</accession>
    <name>A0A162YDM4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_59114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298115.1">
        <property type="nucleotide sequence ID" value="XM_018440434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YDM4"/>
    <dbReference type="STRING" id="763407.A0A162YDM4"/>
    <dbReference type="GeneID" id="29001340"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_59114"/>
    <dbReference type="InParanoid" id="A0A162YDM4"/>
    <dbReference type="OrthoDB" id="5976950at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="384" mass="44129" checksum="7145688B4EB0EAF7" modified="2016-07-06" version="1">MPLSSDPEEPIFDFRTSNARFQQRLLEAQQVATEEQIQDDIAHFYSKTWPENANPLEAEKAELKIQLRRINDKNDILEKELEQQKARRIKEASLSKMTPEERAKAVEEEIEEPIDEDVVFEYMLYIGGAPLPTNPGDMSGSDFVSPHAELREKALQDPEVQKQGEFTHLHFKETNNYLISNPDGSGEIRQCKLKGTTYDQWFNVSFDVYEPDLVVDNFSFDLAIETQVNIGSILQQIKDEGDVLSFFRLLVHYGELENERSKFFDKLKERITNGPITLEELGVDQLKFLGPRDDDPELIFSWKLLAKESNRNDLGVNVCELVVPDISLEMDPSKAWEEKDRIDILKDMPLHFARLVETNGMMVATEVMLEVVFDVPGINITSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZFI0</accession>
    <name>A0A162ZFI0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MAGE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_152523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441003">
        <property type="protein sequence ID" value="OAD66451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284491.1">
        <property type="nucleotide sequence ID" value="XM_018432936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZFI0"/>
    <dbReference type="FunCoup" id="A0A162ZFI0">
        <property type="interactions" value="201"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162ZFI0"/>
    <dbReference type="GeneID" id="28993842"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152523"/>
    <dbReference type="InParanoid" id="A0A162ZFI0"/>
    <dbReference type="OrthoDB" id="205198at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1200">
        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041898">
        <property type="entry name" value="MAGE_WH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF14">
        <property type="entry name" value="NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50838">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="2">
        <location>
            <begin position="46"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD66451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="279" mass="32517" checksum="FA7A59805DFCC2C3" modified="2016-07-06" version="1">MYTDSQRLKGKQRHRPDTDNEEEYSQQPSQRLKYDDSTVNWNEEEFQRKVKDTVRLALACEFKKTAIKRDDINKKVLQDHKFEFKRLHRAANDKLRYLFGFEMVDLPVKEKILAGSRRDGKEVPGSGSKGYMLLNALPEKYNVPELFKYKDEEYENVGVLYCILALIFVNEQTLSKGELEEHLNRLHVTDETQTFGDRDKLLDNFVKQGYLLRKKNNLAANDPNADPDAGIEYYWGPKAKVEIPEENIVNFITSVYNPENTNINKLTEYVYKSAGFSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZIT1</accession>
    <name>A0A162ZIT1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_151692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441025">
        <property type="protein sequence ID" value="OAD67091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285131.1">
        <property type="nucleotide sequence ID" value="XM_018432726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZIT1"/>
    <dbReference type="GeneID" id="28993632"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151692"/>
    <dbReference type="InParanoid" id="A0A162ZIT1"/>
    <dbReference type="OrthoDB" id="2230412at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="577" mass="66068" checksum="D9A9026BAC890D2A" modified="2016-07-06" version="1">MEMQNTQRHQPKSWVKSTIKPRIQSRRMSYMAECNHHTRPTKERKPKERSSLKRMMSKEDEKTKTTPLVFSSLSDQPVSRPPFCLLGHALGANLPLLTPSSSTRPCRSYLVALPVPARVINKIFRQIDAGTILLQPFLLRACLPLTLIQLLYPHIPALTGSSLDLSPFLSVLIPSTHRRRLTPDYIDPSALLPFRLPLPTFWTFLGHAFGNPRFITSFHVDYYFTTSYLLPFPLTFVPSVTFTPTISLTSYTISPQNGLSGLPPGGIILLLLNQMDLSYSAYVSYFDYNAIFSDLQMKIQQSFQQQQHIVTDHINDNYNNCSNLTKIMYCKSCDGKRKNKDSDEMELAKKSYSFHPPNVTPSVSTNKPRINGDDARKLNDHFVAVIGPHSGDETLDCTRQEYELNMEEQRVLHCFKKTAVVYLKSRTDKVERVMIECSGEEDGNHTEGDTLKLMKYTSSCLKNEINQFKYASWTTFGRRRIFAVRCIGNKLTLLSTSRMGIGKWCFVKMRSPIVSRDWEDRYYLNRLMELLMKLKEMPLEQEEATMVLKQQKSGRSPVDTKDTIKAISRSGQAIKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZRX3</accession>
    <name>A0A162ZRX3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zn(2)-C6 fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_173092</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286711.1">
        <property type="nucleotide sequence ID" value="XM_018436939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZRX3"/>
    <dbReference type="STRING" id="763407.A0A162ZRX3"/>
    <dbReference type="GeneID" id="28997845"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_173092"/>
    <dbReference type="InParanoid" id="A0A162ZRX3"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF39">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="683"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1003"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="695"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="738"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="763"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1030"/>
            <end position="1047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD68671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1165" mass="130648" checksum="C9546D0618A487F6" modified="2016-07-06" version="1">MAGAFKWHSCSTKDFPLKRNKVTKACNACRTKKMRCDGITCLSEPRCARCTEHSLLCHYDEKTRRNSSPKKPDLLKRDGNHVATVEHDYKTQNLKNITFSNHYYTHLSAKTTNRPFLYITRLPPLLFGFFDMSSQPHTVWAGFLDLFTQYLQASPTQPGFSRLAKDLSLEILSLFSNYNLLYSPCIEISLINTVINSIQNPLDPSVAPTKGVEIVLTFSVFALVFQAANQALCSRYQKLSLEIERLAHIFYSEAHRRLLSAAFPFQPLGTDRDSLIVLIQSAILLTHYQCTTVCEEQAFITLQIGATFAQRCSFQDLIRQQKTDLIEKEKITLLFKLLHSWDVWFSVYMRRNCWTSRVQNPEELAEPKTIAANKFTNDQEGYQQWAVSVLDQYTEFLSQLTTKQDNSRVDEIKAQLSTLSQLSNLSKDVSNFNDICGMKLSVSALELFHQILTIQIFNCQLKPSSDQLLEGLFDLAALDSCVSAARCIVQSSKTLASTSNTSPAIVYALCVAKSIFDLKEQEQNSQSKRLKQSPLETKSLTKKVLHSEISTNSNEVSILHVQLLEVIKILSTYSEIANTLEMCINHKVSADHMFVHTAPERCGENPDLSVVPSNRLIDTDDNLHCIVSAQPRSANQAISSYLMLDVMSRADMDKEQLSKLSHTSIEREEAASVSSYYSGSIQASINKRRHMTPGQDENTNKSTRAPKRQLSSPGNNDSSPHHQLQQAQPHYSYKRTKTSNLGNNDQEMTVLVGPNSQNQQQQQKEKNEQNQKQEREQSFERGLSEQTVNSHNPYVSMHDVHEVHEDSSGALGICNEDYLWIDIPISDTLQAEQPQHHQHFYPSTQTVKHRSTRISEVSPTPELPSMSSTSTTPGSGIHAVMFEAVPSLEGLDSENSVIPPKLPLPPPKHRDAPQKYWPSVHSRDWNECFTASMVETLHPNTSVIPHEPSFGTPIVQSIGLDTLSSSHEHHSSLVPQTAVETSVIPDADSSEMMYLLYGSSENSGSCGERSSAGSSDPSPRESVVCHPPTNWLSSPLKHTSPLSTLSEHPSQFNAMRQSLESSQQDKSVTKQWDTALLKAPEYKKKANRDFAMLSTNSMAPNHIYPLPIDLSPTPDQRSVVLQSRLTTSGNSSCQHTEDGSVMFSQENPWIQIPQTKIAGDAISWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZYI3</accession>
    <name>A0A162ZYI3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_70471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287911.1">
        <property type="nucleotide sequence ID" value="XM_018442287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZYI3"/>
    <dbReference type="GeneID" id="29003193"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70471"/>
    <dbReference type="InParanoid" id="A0A162ZYI3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="106" mass="12646" checksum="2EA98F18EEB3A28D" modified="2016-07-06" version="1">MIRREHFITQGYLGYSTLLSREDEGYTIYKRMLLIKIVRFMLNLRYSSLLISHYGDVIKEVYLPHVFIVYVAIQSGINIIGSFTDQLYFPILFKLRKSIKISIIYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163A0X4</accession>
    <name>A0A163A0X4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arginase</fullName>
            <ecNumber evidence="4">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHYBLDRAFT_171705</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-arginine + H2O = urea + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">Belongs to the arginase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="4"/>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288361.1">
        <property type="nucleotide sequence ID" value="XM_018436648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163A0X4"/>
    <dbReference type="FunCoup" id="A0A163A0X4">
        <property type="interactions" value="427"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163A0X4"/>
    <dbReference type="GeneID" id="28997554"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171705"/>
    <dbReference type="InParanoid" id="A0A163A0X4"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000005">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0835">Urea cycle</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL24-related N-terminal" evidence="17">
        <location>
            <begin position="325"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="442"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAD70321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="477" mass="51872" checksum="D853C002B0937C09" modified="2016-07-06" version="1">MPEEFKLLSSQHVAIVGAPFSGGQPRKGVETAPAAMMNFGLANQLKELGWTVEFQDNEQEIVELEPAQDPTVLNLKQPKFVSAVTEMISNQVRERALQGKFVLTLGGDHSIALGTVSGVFSAYPDACLVWVDAHADINTPGTTDSGNIHGCPLSFLAGIAEEHPDFSWVKPCLKANRLVYIGLRDVDDGEKKILKELGIKAFSMHHVDQLGIGKIVEQALDYVNPDRNLPIHLSFDVDALDPSVAPSTGTPVRGGLSFREGHYICEALVNTGLLVSADIVEVNPVLLDEESAFQTIQVGCSLARCCLEAYYTNPSFPILGSAAAMKLEICSFSGHKIYPSKGKTYVRIDSRSFRFINGKSESYFLQRLNPRKIKWTVIYRRLNKKGITEEIAKKRSRRTVKHERAVAGVSWDAIRAKRNQKPDARAAARQAAIAKSKEAKKAAAATKKTTTGSAAQGAKVSKQGAKGFAPKAAATSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AES5</accession>
    <name>A0A163AES5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 9">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_113284</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 9"/>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291011.1">
        <property type="nucleotide sequence ID" value="XM_018428337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AES5"/>
    <dbReference type="STRING" id="763407.A0A163AES5"/>
    <dbReference type="GeneID" id="28989243"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_113284"/>
    <dbReference type="InParanoid" id="A0A163AES5"/>
    <dbReference type="OrthoDB" id="5152799at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000017">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF6">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD72971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="446" mass="50431" checksum="23489817B63822CA" modified="2016-07-06" version="1">MNYEKKREYYVTSVITYSHLYITINKAVAYRLIKDDLALDGNPALNLATFVTTYMEDEAEKLMAENLSKNFIDYEEYPQSAELCNRCVNMIARLFNAPMDNPCFESLGCSTVGSSEAIILATLAMKRKWQLSRKAKGLSTENPNIVMGANCQVAWHKAVRYLEIEGREVECTADLLYMDPQKAVDLVDENTIGVCAILGSTYTGHYEDVKAINTLLEEKCEENGWDVGIHVDAASGGFVAPFVVPELEWDFRLSRVVSINVSGHKYGLTYAGVGWAIWRSPEYLPKDLIFNINYLGSDQASFTVNFSKGAAHVIAQYYVLIRLGRRGFQKIMSNLTDTADHLAERLKATGHFEILSEGGGRGLPLVAFRLSTPHHYDEFDIARRLRQRGWIVPAYTMAHELEHMKLLRVVVREDFSRSRCELLARDVVSVLKTLDLLDEKSIEAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AET7</accession>
    <name>A0A163AET7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type zinc finger transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_146295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291021.1">
        <property type="nucleotide sequence ID" value="XM_018431621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AET7"/>
    <dbReference type="GeneID" id="28992527"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146295"/>
    <dbReference type="InParanoid" id="A0A163AET7"/>
    <dbReference type="OrthoDB" id="2201430at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="49" mass="5193" checksum="E134EB2EE9CE09E8" modified="2016-07-06" version="1">MCNSSSHAVSLPPKNINPAIDIPPLDMTGGQCTWCGKYGHKNPGCPLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AMB5</accession>
    <name>A0A163AMB5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted flavin-containing polyamine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_78835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292521.1">
        <property type="nucleotide sequence ID" value="XM_018443391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AMB5"/>
    <dbReference type="STRING" id="763407.A0A163AMB5"/>
    <dbReference type="GeneID" id="29004296"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_78835"/>
    <dbReference type="InParanoid" id="A0A163AMB5"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF313">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007841537" evidence="1">
        <location>
            <begin position="27"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="46"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD74481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="497" mass="55859" checksum="4252AE7F2587EE5D" modified="2016-07-06" version="1">MKFHSISLAISLSLALATSFYGQVDAKKITKSKVAILGGGVSAINAARHLTDAGIDDFVIIEAREILGGRAQDVPFAGINVEAGCNWVQGLGDNPINQLRQKYNLTTSVTDGDSLAFFDENGKTDASETYNAFMAASDRMTELSFERIKNDQVDLSARAGLDLAGWFPQTPMEKAIEYYVFDWEMGETPEVSSMQFSVENSNWTYTGFGPDSDGDLFVTDPRGFKHIFLEEANLFLKKDDSRVKLNSTITKVEHNKRGVTIHTEDEIFKADYAISTFSIGVLQNHDVEWSPALPAWKMEGIYGFHMATYTKIFLNFPTQFWGDEQFSVYADPDKRGYYAAWQNLNAPGFLPKNTDTNIFFVTVTQEQSYTVESMEDSEVQAEIMEVLKTMYGKDIPEPTEIFIPRWHSNPLFRGSYSNWPVGELEEHHANMKAPINNRLFFAGEAMSEDYFGFLQGAWFSGAEVGDNVAQCIKGRCPPAPYYPEINNVNLKSDFVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AR61</accession>
    <name>A0A163AR61_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BACK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_72014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293261.1">
        <property type="nucleotide sequence ID" value="XM_018442580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AR61"/>
    <dbReference type="STRING" id="763407.A0A163AR61"/>
    <dbReference type="GeneID" id="29003486"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_72014"/>
    <dbReference type="InParanoid" id="A0A163AR61"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BACK" evidence="1">
        <location>
            <begin position="118"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="266" mass="30678" checksum="48AEDCD0893E9E1E" modified="2016-07-06" version="1">MKNSYNSALRNDLWEYDYQENANIYDTTHSLVNNIFNPEPEPEPGSDTETKPIKLVTSKSLDPRVFQLLLGYVRNDASCIDRSDIISIIETSNLLQCKILSTKAFMYLRSQINQSNLLETWHIADTYSCKDTIDACVIYMLKNYQSVFNDPSWLLATTGQVYKIFTLDGLNYVEHYDALSDALVSWRVASLTQLLNELEASTKDSTHATVIHRLHQTVKAPKILTENEEDWIDKDNLLRKVREQMETIENHFIYMMGHISVLKKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AT07</accession>
    <name>A0A163AT07_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_166812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293621.1">
        <property type="nucleotide sequence ID" value="XM_018435499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AT07"/>
    <dbReference type="GeneID" id="28996405"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166812"/>
    <dbReference type="InParanoid" id="A0A163AT07"/>
    <dbReference type="OrthoDB" id="3239894at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="428" mass="48850" checksum="EC2061903691BF52" modified="2016-07-06" version="1">MMQAMAETMVVPMDYTVLGSKIGKGFGHMKADEWKSWVLPSITFSDLDDAHQLLQEFCNGCKCIYTANVLTCNMHLHPHLRETVRDFGPVYRYWLFGFERYKGLIKNVSTNRKDSFEATYMQSFVQDTFKGDYVNVVLQCPSQVPFLPLLGKLTATAQPSSSKNKMTFPQRPFRLAAFVHAYSNPSLPVLGNEPLPPSTFPLHIKPSSAMSNVDYPHLLDYYKVAYHIPGLESYQFPSSSLSFVDNQSTKLRSINLLGQVYKGSKYASGRGSFVQSLFLGSQGNNRLAYTGQIQYLFLHSFTPPVVNTELQARIVYQDKHVFAFVKWFQIEHNRSRELESVNICSADFIACDFECILPVHRISSVVATCNYKTSANNKKTLVNALPKELLVFKTKIFNYIELLFQSMLYYPSTESARLRIYSQYNVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AU09</accession>
    <name>A0A163AU09_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Autophagy protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_59343</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Conjugated with ATG12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Preautophagosomal structure membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATG5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293851.1">
        <property type="nucleotide sequence ID" value="XM_018440477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AU09"/>
    <dbReference type="FunCoup" id="A0A163AU09">
        <property type="interactions" value="247"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163AU09"/>
    <dbReference type="GeneID" id="29001383"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_59343"/>
    <dbReference type="InParanoid" id="A0A163AU09"/>
    <dbReference type="OrthoDB" id="272162at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.190">
        <property type="entry name" value="Autophagy protein Apg5, helix rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007239">
        <property type="entry name" value="Atg5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048940">
        <property type="entry name" value="ATG5_HBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042526">
        <property type="entry name" value="Atg5_HR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048939">
        <property type="entry name" value="ATG5_UblA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042527">
        <property type="entry name" value="Atg5_UblA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048318">
        <property type="entry name" value="ATG5_UblB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040:SF2">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20637">
        <property type="entry name" value="ATG5_HBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20638">
        <property type="entry name" value="ATG5_UblA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04106">
        <property type="entry name" value="ATG5_UblB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="2 5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="3 5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Autophagy protein ATG5 UblA" evidence="8">
        <location>
            <begin position="12"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 alpha-helical bundle region" evidence="7">
        <location>
            <begin position="132"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 UblB" evidence="6">
        <location>
            <begin position="195"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD75811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="290" mass="33236" checksum="5BF37471495E679F" modified="2016-07-06" version="1">MSAFDIAISETIWDGKLPLQVTFHPTESISSARTPDPIYIEVARLSYLSLLTHQLHSIYTGLGIQTQPENVWYDYNGEPLKWHFPIGLLYDLYNFPISQVPTFGEKASLPWRINIHFDEFPIDKILRNPTLDTTQDMFMSMLKEADFLRHGTTKRVMNMSKRDQTQLWQSLVQGKYSEYWSVNKHLLENGQLARHIPLRLYMPYKCPPIQELVPGNTEEHPLLIGDAMTRILPDLFPSDDQEECDAIPVIHGVPLPLDTPLGWASDNLCFADNFLHIVISKKGTDNGLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AWQ2</accession>
    <name>A0A163AWQ2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_166262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294331.1">
        <property type="nucleotide sequence ID" value="XM_018435388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AWQ2"/>
    <dbReference type="GeneID" id="28996294"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166262"/>
    <dbReference type="InParanoid" id="A0A163AWQ2"/>
    <dbReference type="OrthoDB" id="2274111at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="227" mass="25456" checksum="497D60C4AA2737E9" modified="2016-07-06" version="1">MPVYSPSLASFWDDMRAIEPPSIRLERRARERSSVWRHSFHPLEMPPAETTANNPDYSPISSTDSEPIAIFEADSSDDSQTTTPGRPEDLETVVRALHRFHLFRRLLPATERPSALGLSLPSTAVLSLLCDEDNKQEWLTQYLTPDGDFDPGLAVLAAAVYEQSRTEGPVCCRDILTAGEELYGEDWPSRLHPKGRSHVLDKLSTVAHIQQKLKDSGRLETVDHAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B0M2</accession>
    <name>A0A163B0M2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CYP509 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_16868</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295621.1">
        <property type="nucleotide sequence ID" value="XM_018435916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B0M2"/>
    <dbReference type="STRING" id="763407.A0A163B0M2"/>
    <dbReference type="GeneID" id="28996822"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_16868"/>
    <dbReference type="InParanoid" id="A0A163B0M2"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00302">
        <property type="entry name" value="cytochrome_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF50">
        <property type="entry name" value="BIFUNCTIONAL ALBAFLAVENONE MONOOXYGENASE_TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD77581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="426" mass="48431" checksum="3C6F0E76681F1AB8" modified="2016-07-06" version="1" fragment="single">WTVYTANPEAVQYILMKGEIFPKDTNFMNVLSRDSLTIRFFGSSNVAFISGEPWKHQRKTMNPAFRRTAPVDLFGRIVPDMFRLIDKTDGNIFIFDLLQRVTFDALGKALFGFDFRATVEEDSAWRAAYIDTMAGVTAPILNIIPSLEYILRYFYPDYNKASKGVDKLNALILDMVNKKKKKLEESKDQPDGGQEKDLLTLILEAEMKENKSSESDDLRANMATFIMAGHETTASSVSHCIYYMAMNKNVQNKARREALDILGDDSSTAPPTFDDCKRINYINMIVKEALRLSVTSGALMDRVATEDVTLAGEFIPKGTYISVDIEALHKNPTIWKNPTVFDPERFSKGGEHEQHRGITWAPFSDGNRKCLGVNFSMAEQQVLLLMLLKHYEWDLSENSIHKNGIVYNSIFSFAPKTLSIKFHKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B7M8</accession>
    <name>A0A163B7M8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_157626</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296741.1">
        <property type="nucleotide sequence ID" value="XM_018433653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B7M8"/>
    <dbReference type="FunCoup" id="A0A163B7M8">
        <property type="interactions" value="762"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163B7M8"/>
    <dbReference type="GeneID" id="28994559"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157626"/>
    <dbReference type="InParanoid" id="A0A163B7M8"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000552">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD78701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="306" mass="35044" checksum="FEA4A794786C5543" modified="2016-07-06" version="1">MGRHCQLVMGPAGSGKSTYCATMMTHCQAAGRKVHLVNLDPAAEHFEYEPTIDIRELITLEDVMEELDYGPNGGLIYCLEFLLNNIEWLEEEIGSYDDDYLIIDCPGQIELYTHFPIMRRLCEQLGRWNMAICGVYCLESQFIEDKSKYFSGVLSAMSAMVNLEISHINVMTKMDLVQGDYGNRAADEDIEGETESEKKKRQRKKRAQMERVMVEREMDRYLEPDPLLIAEEAGALEEKPSAWTLKFQALNQAIVQLIDDYSMVSFIPLNITDEESVEYVLSSVDHAMQYGEDLEPKEPDDKVEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BBD1</accession>
    <name>A0A163BBD1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Autophagy-related protein 16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_179092</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297461.1">
        <property type="nucleotide sequence ID" value="XM_018438099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BBD1"/>
    <dbReference type="STRING" id="763407.A0A163BBD1"/>
    <dbReference type="GeneID" id="28999005"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179092"/>
    <dbReference type="InParanoid" id="A0A163BBD1"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22887">
        <property type="entry name" value="Atg16_CCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045160">
        <property type="entry name" value="ATG16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013923">
        <property type="entry name" value="Autophagy-rel_prot_16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878">
        <property type="entry name" value="AUTOPHAGY PROTEIN 16-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878:SF8">
        <property type="entry name" value="AUTOPHAGY-RELATED 16, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08614">
        <property type="entry name" value="ATG16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Autophagy-related protein 16" evidence="7">
        <location>
            <begin position="7"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="287"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="329"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="414"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="472"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="502"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="60"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD79421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="540" mass="61187" checksum="8C61F89567B39F8D" modified="2016-07-06" version="1">MTFRDTLLDQLRKRDKRERQWKEMINANQRLLHHAIELQKRNDQLILYESNNNSTHTQNAPANQQQINDLDRRIRELHEERAEMYKSQSENAQRLVHMNEQLRAKEETEKQQAEEIKSFSEKINALSKECDLQAQQLREKNIVIQILQDELATLHLEIVTTEDRSKNLRKENDQLLQRWMNLKNEEAEKMNEATQFYEELRILARNNGQTLRQVNGKWVMEPSPSTTSSKNRTPAEDDLKRSSRILSNILLPSRVTKKFTMHEGEIYCVQASSTGSMFATGRVNQTLGGALQTITSVDFNSTDELVLGASTDNATRLWQLSTGRIKHTLTGHIGKVYSAKFNADSNRVVSGSHDRTLKVWDLQKGNCIRTIFTFSSCNDLCLGDADGLTLISGHMDNNIRVWDTRTGNGIKDMTGLHTSQITSVCMSPGGSTVLTNSRDHTLKIIDLRMYEVVQSFQADTFRNGINWSRACFSPDGHYVAAGSADGVLHIWNSRSGKLEKSIEGHGAAVCGLSWNPSGSLLYSADKSKVVCMWDTAHSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BDC2</accession>
    <name>A0A163BDC2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_61877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298861.1">
        <property type="nucleotide sequence ID" value="XM_018440864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BDC2"/>
    <dbReference type="STRING" id="763407.A0A163BDC2"/>
    <dbReference type="GeneID" id="29001770"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61877"/>
    <dbReference type="InParanoid" id="A0A163BDC2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="16002" checksum="9328FA1E0BFDB9B1" modified="2016-07-06" version="1">MRSNGVSYITNSIFVDEAEFKVHLIRRAGSTKRSEKSTVKSLAKRGLGITILAAVAYQGVEKFQAKMVHGGTPESVFIEFVKTIMDSLDQDNADPHNFIINNVSRNKFPLVTLVIKHICRIPDINSNVRGSGETWKRWYSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BET9</accession>
    <name>A0A163BET9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_138678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299171.1">
        <property type="nucleotide sequence ID" value="XM_018430047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BET9"/>
    <dbReference type="STRING" id="763407.A0A163BET9"/>
    <dbReference type="GeneID" id="28990953"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138678"/>
    <dbReference type="InParanoid" id="A0A163BET9"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="51"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD81131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="331" mass="37872" checksum="6BA9BA295D20DCB1" modified="2016-07-06" version="1">MTKLYSKSKDTWVYLNKNGTEVINPEKAKNPITFTWLGQSTCLITIEGLAILTDPVFTRRSINEYLGPKRLRPVPCVLEDIQENLDIVLVSHNHFDHLDSKVVAKLGNSVAWYVPLGLKYWFVERGINNVLEMNWWEETKIKLRPDITVACVPAMHWSGFRTPFDKNETLWCSFVIKGQNENIFFCGDTGYSSELFKAIGSRYSPLSLAAMPIGSFEPEFLMKHLHMGPTEAVKAHCDLGHPKVSVGIHWGTFMMSEEHYMDPPRALNQAWKDYVKSRQRIQRTQRIQPELDSIDNCLSSSVRESDSDRILDSQFITTALGETLWIKSGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163D6Y0</accession>
    <name>A0A163D6Y0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Biogenesis of lysosome-related organelles complex 1 subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_149604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287240.1">
        <property type="nucleotide sequence ID" value="XM_018432303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163D6Y0"/>
    <dbReference type="GeneID" id="28993209"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149604"/>
    <dbReference type="InParanoid" id="A0A163D6Y0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="130"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="20148" checksum="7C8354A96626E740" modified="2016-07-06" version="1">MVIFDVTPIIQDANQLNEAILGKSHRELQQTLDSFVVHFDTFDKIDDSSEKTASNTFVGPDTLASNYVQLTGCHQRLEKSLQNTTSWDATVDAATRTNAAMDELQSAVMKMEKSGTERVQLLEREKALFMAEVEERRAQVAQEFRRKQDQLEELYANKTREVIYHNLVGNNHQWAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DCB2</accession>
    <name>A0A163DCB2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein kinase ATR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_99801</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288410.1">
        <property type="nucleotide sequence ID" value="XM_018444108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DCB2"/>
    <dbReference type="STRING" id="763407.A0A163DCB2"/>
    <dbReference type="GeneID" id="29005013"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_99801"/>
    <dbReference type="InParanoid" id="A0A163DCB2"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00892">
        <property type="entry name" value="PIKKc_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD70370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="260" mass="30355" checksum="81FCD4872CDC9161" modified="2016-07-06" version="1" fragment="single">PKKIELIGTDGKRYCFLCKTSDDLRKDARVMEFCYMINNFLRKDPEARDRSLYIRTYAVIPLGHEWGLLQWIDNLETLKLITAREYEKHGIDYQKINRFIKEILPRQEYKDIFISKSNLFCLTFFLCYSFPCHLNNWFLDCFPEPSLWLAARTRYTNTLAVMSIVGYVLGLGDRHAENILFDRLSGDCIHVDLNMLFDKGSDLPVPEVVPFRLTQSLVDALGVLGYKGKFEKSCRVTLRVLQENKESLLSVFETFVHDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DD53</accession>
    <name>A0A163DD53_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_69629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288580.1">
        <property type="nucleotide sequence ID" value="XM_018442132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DD53"/>
    <dbReference type="STRING" id="763407.A0A163DD53"/>
    <dbReference type="GeneID" id="29003038"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_69629"/>
    <dbReference type="InParanoid" id="A0A163DD53"/>
    <dbReference type="OrthoDB" id="2289305at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="203" mass="22216" checksum="6056F655E4C352D2" modified="2016-07-06" version="1">MLANVDQQLIIKCSIVIVLSIQGLHTLSKIRFLVHVVDQLIIDNLLIPIVLTIATTLCISAAVETVQEDVLVLTSVKLRAQIIISMSFHLWKAGVPFCNAYMSIDECLKATSEQSSRFGLCYSNGKTIIPLPIATLQKLLDFVTNHDSSDCQATNFYKNIRAFNSAFAFASIKANVDERLASGTDGVSTFHVNGTIYHNVGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DGJ2</accession>
    <name>A0A163DGJ2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_171138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD71080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289120.1">
        <property type="nucleotide sequence ID" value="XM_018436522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DGJ2"/>
    <dbReference type="GeneID" id="28997428"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171138"/>
    <dbReference type="InParanoid" id="A0A163DGJ2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="117" mass="13602" checksum="4885AB1826989531" modified="2016-07-06" version="1">MAELEILICSHLNAFISQSLSRLTKMNTVDPIFDSPYIIQLEMTLHILSSVYKDNLSLLIYILATVKDIIRNAMDYQYRHLFFACSFPIFTMYFFSVDNYSIQTVSSRPVEAIMDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EEF2</accession>
    <name>A0A163EEF2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_163329</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296250.1">
        <property type="nucleotide sequence ID" value="XM_018434775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EEF2"/>
    <dbReference type="STRING" id="763407.A0A163EEF2"/>
    <dbReference type="GeneID" id="28995681"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_163329"/>
    <dbReference type="InParanoid" id="A0A163EEF2"/>
    <dbReference type="OrthoDB" id="2283980at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="78"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD78210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="179" mass="20381" checksum="9CE81C984032C1C5" modified="2016-07-06" version="1">MLLNRYSFPRRLGDMSILFGMSESNVSVVCRGFESIVMNQIKWGLQFNIKQFRPENLERFASAIYDKGAALPNIVGFIDGTMQAISRPSQGNEVQKAFYNDWKHMHALKYQSIVTPDGITSSLLGPYVGSRHDQYIYTMSKTEARLNDYACKISSIFLIQTRKIKIFDLLKTDVSDGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EHL7</accession>
    <name>A0A163EHL7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_122058</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296720.1">
        <property type="nucleotide sequence ID" value="XM_018428846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EHL7"/>
    <dbReference type="FunCoup" id="A0A163EHL7">
        <property type="interactions" value="505"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163EHL7"/>
    <dbReference type="GeneID" id="28989752"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_122058"/>
    <dbReference type="InParanoid" id="A0A163EHL7"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF111">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007747991" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="23"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="517"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD78680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="625" mass="70376" checksum="309F5953174535EF" modified="2016-07-06" version="1">MIPRGLAATFLCFVLCTSLVSGFYLPGVAPHDYAEGDPVKVFVNSLTPMSNSQLKSVISYDYYDPRFHFCRPENDLIEVPESLGSVLFGDRIMGTSFELFMKKNETCKSLCITKPIPKKDTAFINQCIAEDYSLNWFIDGLPAAHRKQDERTDEEYWNIGFQLGSGGKESPVLNNHYDIYIHYHERTTQANRVVGVVVVPSSKDTKLEGGKPVCKISNEAFKLNPEGGSEVVYTYSVYWIPSATAWATRWDNYLHILDPSIHWFSLVNSIVIVLFLTGMVAMILIRALHKDISRYNAVEAQEDVQEDYGWKLVHGDVFRAPTHPMLLSVFVGSGAQLMVMTALTLMFAVLGFLSPSNRGALGTVMVIFFMVCGCISGYVSARIYKMNGGEQWKLNVLLAATLFPSMLLVSLFVLNFVFIGLQSSGAVPFGTIMVVLGMFGLIYIPLSVAGSYLGFRKPRIEHPVRTNQIPRQIPDQPLYLRSVPSIMMGGILPFGAIFIELYFIMNSIWFHRIYYGIGFLFLVFIVLILTCSQVTILMCYFHLCNEDYHWSWRAFLTSGAAGLYVFLYAVLYYFTKLEFRTFTSSVLYFGYSSIISVMLGIMTGTIGYLACLVFLQRIFASIKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EPW1</accession>
    <name>A0A163EPW1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_178727</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298760.1">
        <property type="nucleotide sequence ID" value="XM_018438036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EPW1"/>
    <dbReference type="STRING" id="763407.A0A163EPW1"/>
    <dbReference type="GeneID" id="28998942"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_178727"/>
    <dbReference type="InParanoid" id="A0A163EPW1"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF3">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD80720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="536" mass="58706" checksum="0E788D41381571D1" modified="2016-07-06" version="1">MAERSPRPPFSPTSHPPSSDTNQWSSQDYNSDKNRVGMTKTTPRDDRQVFVIDRPESPTLPPEGGQDDVYEDIPQTPKSSFDQPRSPGDFNGINSTRIPLLSNSSTTSSISSDNWQNVSGSGSFPNGTKGGPHYQSMERTRSVQTPTSAYAPPSQVPPSRRNGSSNQHLRHAVSANGLHHKARRPLHVNDHMAAAIELSASPNVPLAPAAGMYWSRAITYGRGPSRPLRAHTADLVGEHLYVFGGCDIKTCFNILYVLDMDTLTWSKPRTSGHAPPPCRAHSCTVVERDSGGGKRTHYLYVFGGGDGPNYFNDLHILNTDTLVWTKPLVGGSPPSPRRAHTTCLWNNKIIVVGGGDGARALADVHALDISDLNKPSWTQLDPSGSPPIARGYHTSNLVKDKLIVFGGSDGHECFNDVFVLDLVSNQWTQIELDRGISRLAHTATQVGSYVFVIGGHDGSRYSNDILLLNLVTMNWESRKIYGVAPSPRGYHTSVLYDSRLYILGGYDGRNVFEDVYQLDLSACAYLPQITNFEIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EQ50</accession>
    <name>A0A163EQ50_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_161422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298820.1">
        <property type="nucleotide sequence ID" value="XM_018434398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EQ50"/>
    <dbReference type="GeneID" id="28995304"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161422"/>
    <dbReference type="InParanoid" id="A0A163EQ50"/>
    <dbReference type="OrthoDB" id="2288118at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="291" mass="32381" checksum="D4B180677907647A" modified="2016-07-06" version="1">MSTTSLPHQRSSSNSSDLLPLPRDLDEDSFSRDLIHQFDKKRSRLRLEMVELENSHDAPSLHSSATPPTMLTVSPSPPTPTPAPAPPPSTTSTSPDPTNRRRSAGDLLRRSSAYFKSKLDAFKVSRSHDNLRDVHSIHDPTPSKTLGIRHLKKKPTRQDLFSLSSTSLPPPAKIAINTTIAIPQFQHNTHHQTQQATLHAHFGAIKPPVISQYPPKPLRYSPVDPPNDDHRPIVHRISLPLLRRNQPDPNEGGTTRRRSDTEATHQKKKAINTRKSKKGKERANLAEGSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167J4X2</accession>
    <name>A0A167J4X2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_95645</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441014">
        <property type="protein sequence ID" value="OAD65149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283189.1">
        <property type="nucleotide sequence ID" value="XM_018443921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167J4X2"/>
    <dbReference type="STRING" id="763407.A0A167J4X2"/>
    <dbReference type="GeneID" id="29004826"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_95645"/>
    <dbReference type="InParanoid" id="A0A167J4X2"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000104">
        <property type="entry name" value="Transcriptional repressor protein YY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000345">
        <property type="entry name" value="Zinc finger protein Gfi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD65149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="53" mass="6323" checksum="20435281E1DC9AB9" modified="2016-07-06" version="1" fragment="single">YVCMFCGKKFSRPSSLRIHTYSHTGEKPFVCTEENCGRRFSVQSNMRRHMRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JVH0</accession>
    <name>A0A167JVH0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_70241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441000">
        <property type="protein sequence ID" value="OAD66770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284810.1">
        <property type="nucleotide sequence ID" value="XM_018442241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JVH0"/>
    <dbReference type="STRING" id="763407.A0A167JVH0"/>
    <dbReference type="GeneID" id="29003147"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70241"/>
    <dbReference type="InParanoid" id="A0A167JVH0"/>
    <dbReference type="OrthoDB" id="2275179at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="237" mass="27274" checksum="BB9FF3DF1D362A77" modified="2016-07-06" version="1">MTLYKRIVDLTIKKYHKSVVKVASMFSLSRSTVDNIKNSFIDNGKIVVKQRGGRKKECTKIMEEHSEYLIEILDEDCTLTLEMMREKLYECFDDLQEKDIMFSILYCHIMNNIGFTLKRTKAVEERRNDPDVIEARRKFVESLPELGVAYVANCIFIDEAGFNRALNISILAAISNNGVKSMSAKLVPKGTNIELFIKFLKTIIKTLDNINAVPQWFILNNAPIHRSHLVRDFMATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K261</accession>
    <name>A0A167K261_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminopeptidase P N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_178372</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441025">
        <property type="protein sequence ID" value="OAD67099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285139.1">
        <property type="nucleotide sequence ID" value="XM_018437981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K261"/>
    <dbReference type="STRING" id="763407.A0A167K261"/>
    <dbReference type="GeneID" id="28998887"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_178372"/>
    <dbReference type="InParanoid" id="A0A167K261"/>
    <dbReference type="OrthoDB" id="10261878at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF1">
        <property type="entry name" value="XAA-PRO DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="7">
        <location>
            <begin position="13"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD67099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="476" mass="53562" checksum="5868C5EE65A6023B" modified="2016-07-06" version="1">MCDPVFPYSKKRISTSYHCRRVGKLLQTNPNERAVIYHRGGQGAVRDDTDVEVDFRQESYFFYLSGVEHPGFHILVDLYNDTIYLIPPTVPDTEILWKGEPDTAKELLEIYDADKVIAEADVPALLQVLCPQVVYVLDTVDTSIIKAAGIHECQLDKVCLRVAMDESRLIKFPWEIEHIRYAAQISSHAHMALMQRAQAGQPESYCEALFRWVCARNGMPRQCYIPIIASGSRAATLHYTRNDKTLPEGEHAMLLVDAGGERFCYGSDVTRTFPISGRFSSEAKTIYEIVLKMQETILSQLKPGAMWAGLHNLGVYILCQELIRIGILVGGTHEELLHLGLPRAFYFHGTGHSVGLDVHDVGGRTAGVLTNSYHERKIQSQMLISRPLKKNMVLTVEPGLYFNPTSIAMWTQKPGYAKYFNMDMINKYMPVGGVRIEDTVVLTEDGYDNLTIAPKTVNDIEALMACRAQSYMDSMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K4G2</accession>
    <name>A0A167K4G2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_63745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285299.1">
        <property type="nucleotide sequence ID" value="XM_018441168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K4G2"/>
    <dbReference type="STRING" id="763407.A0A167K4G2"/>
    <dbReference type="GeneID" id="29002074"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63745"/>
    <dbReference type="InParanoid" id="A0A167K4G2"/>
    <dbReference type="OrthoDB" id="10034966at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF34">
        <property type="entry name" value="NOTOCHORD-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="834" mass="95024" checksum="94655B2FDA2B1501" modified="2016-07-06" version="1">MIEEEQEEAMGENISSLRERIFNMASSTINSNKKSDLPTLAFEDCQSLLDFSAASDEWNRSMPPFFPFQNLQTLVLQVFVDSNDSMISVSMLTKVMYTINLLFELKKRADFKLPKVETLLNYQYNKFNKVPLSPTTVKKVTIKATSNLGSGITSQVKTIDCHFNLPSDHLRLLLANPKKAFYLSALPDYTENQCLSVQQGEKWRRNPLFQHQFVQTNGKDFWIGDVAVLHSGQSILVERFYMKDMLALFDRYLVEQGSDSEGHALHKAIITPLAIFSDDTSKNLTKTHGMYNSVLVNFPAMSYSMRNRRKNNFFVTAVSQQAGFKSTHLMPVLATDLKTLENGVDMYSLTYDETVTVCAPLLFIAADNARHAELVGLKHLTSNFLCRRCYYRNLSRFGFDDFDSEYLVCDCQHRTKEHYKIAATDPTCKEKAIPGILPNANNLYLKMEKPINKALILADLGYSHTGTDNLLCLQSFNPALDTPVEILHTVALGVCKYLLNHLFKEVLKGNTASQVKLSDLLEQEKGSRDFTRTFRKKLRHSGSYLGKEFKILAQVLPPILNTEFTNNTEVKVDSDFDQYLNNVNNTARRLVKSLYEYDIYANTKFSLTLKTHLLLHLKEDIKRFGCALHFETEKGEQFNKFIRTHLVYSNRCADNRDLALKFGKQDMLRHIASGSSWIDKSTGTQVKGGSGIFAFLHDQENKFSDNFFGKHQEFVNNNHVKTKIVAGVSVAFSYSNNANRMFVGRAVESNSILRIQHYQLFSPNLNLATVRCQPIEHYCNLEDVKIECMLHLTSGSETQNYNFYTRISLGMIYCLTSVGVTIMTSSHKSYFFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K7P7</accession>
    <name>A0A167K7P7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Catalase</fullName>
            <ecNumber evidence="12">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHYBLDRAFT_183496</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 13">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="12"/>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285470.1">
        <property type="nucleotide sequence ID" value="XM_018438777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K7P7"/>
    <dbReference type="FunCoup" id="A0A167K7P7">
        <property type="interactions" value="318"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167K7P7"/>
    <dbReference type="GeneID" id="28999683"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_183496"/>
    <dbReference type="InParanoid" id="A0A167K7P7"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08156">
        <property type="entry name" value="catalase_clade_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040333">
        <property type="entry name" value="Catalase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF9">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="7 12" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="4 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 12" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="15">
        <location>
            <begin position="7"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAD67430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="484" mass="54554" checksum="0E3B4345F1AFD684" modified="2016-07-06" version="1">MSKNILTTSNGNPVENDQTSQTAGPTGPVLIQDFHLIDKLAHFDRERIPERVVHAKGAGAHGYFEVTHDISKLTKAKFLNGIGKKTPIFTRFSTVGGAQGSADTARDPRGFAVKFYTEEGNWDMVGNNTPVFFIRDPSKFPDFIHTQKKNPRTNLPDADMFWDFLSLVPESIHQVSILFSNRGTPDGFRHMHGFSSHTLKLVDDKGQFKYVKWHFKTDQGVKNLSASEAARISGIDPDYSTRDLFNAIERGEHPSWSVYIQIMEPNDAKSYRFDPFDITKVWPHSDYPLVPVGKMVLNRNPENYFAETEQAAFSPSHMVPGIDVSPDRMLQGRLFSYPDTHRHRLGPNYTQIPINQPVSRVANYQRDGFMTVNGNGGSNLNYGPNSFDGPYQNDIVGSTYTAEEISGFTGRFTYELKDVDFVQAGDLYRVMSPEERTDLVNNIAGHLKNAKKHIRDRQIAHFKRADREYGSRIESAILGLTAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KFM0</accession>
    <name>A0A167KFM0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phospholipid:diacylglycerol acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_127956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286027.1">
        <property type="nucleotide sequence ID" value="XM_018429198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KFM0"/>
    <dbReference type="FunCoup" id="A0A167KFM0">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167KFM0"/>
    <dbReference type="GeneID" id="28990104"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_127956"/>
    <dbReference type="InParanoid" id="A0A167KFM0"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="655" mass="72612" checksum="64F8564DEBF770F7" modified="2016-07-06" version="1">MEDVSALFKPKPVPFWKRKRFHFVVGVTVGLMGALYGASTTPMAQTHLNDLQAFLALQIAEMDIQSMLPATEAVDEMLGNFTSFLKPAPTSDIPFMPATAFKDELDLKPHFPVVLIPGIVSSGLESWGTSEKSRKYFRKRMWGTTTMFRSVLLDKELWTEHVKLDTTTGLDPPGIKLRAALGLDAADYFVAGYWVWAKIIENLATIGYDSNTMHLASYDWRLSFSNLQIRDKYFSRLMATIETSKKTGGLKTVVITHSMGGVLFPYFLKWVESPQGGNGGPTWADDYIESFVNIAGPMAGVPKAMTAMLSGETRDTMAVGSFGAYLLEKFFSRKERASLMRSWGGGSSMLPKGTDLIWGSHERAPDDEEDESHQSHGNMISFVSPSLLPQNNLKPDITDGLIQNHTSEDAMNLLHRVAPFDYNEMLRLNYSYGITTSKKQLEANSEDPTKWANPFESQLPKAPNMKIFCFYGVGLPTERSYYYSASTDGTSPACNNSSRCDESIDGNCTLGGTTDNITEIYAHQLQAPHLFIDSTVNDPAARVETGVRFGNGDGTVPLISLGYMCTPSGGWTKHADLYNPGHNPIIIKEYINEQPESKLDVRGGSKAGDHIDILGNWEMTLDVLKVVSNQSFNVTSRIITKIDEYAQKINIQHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KHW9</accession>
    <name>A0A167KHW9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA guanylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_173629</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.50" evidence="2"/>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286179.1">
        <property type="nucleotide sequence ID" value="XM_018437072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KHW9"/>
    <dbReference type="STRING" id="763407.A0A167KHW9"/>
    <dbReference type="GeneID" id="28997978"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_173629"/>
    <dbReference type="InParanoid" id="A0A167KHW9"/>
    <dbReference type="OrthoDB" id="200924at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="mRNA capping enzyme adenylation" evidence="12">
        <location>
            <begin position="56"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA capping enzyme C-terminal" evidence="13">
        <location>
            <begin position="251"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="384"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="438"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="404"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD68139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="642" mass="72731" checksum="D4485381D9300E5B" modified="2016-07-06" version="1">MAHPLSPNPLHLETYANDTSMPESIGKRVDPIYSKTLQARAKELLRTQDDSFPGSQPVCFESKHLSVLEREDYFVCEKTDGVRYLLFFVHSPKGPASFMFDRHQTWHYIPNLVFPVRNRDKEYLKDTLMDGELVADIDGDKKTWRFLVFDLMAINAVPVTQRSFNTRLGMLRQEVLMPFDASLRNLEDSTKPPFTLELKKMERAYGLHLVFGQMSKLKHSSDGVIWTPVKCPYVPGTCEKLLKWKPPELTTVDFRISARWSKEHKPMYALEVLSHGVTYKFYDHFQPEPALAAGWKNSLPDGRIGEFRFDSNWEVTIVEQGYAPKMRKGGWRFVRFRDDKETANDENVVKKILCSIQDGVTQKQLLAHMDRVRAAWKAREKGLPIPTFESPKDALPPHSAPLASGNSSILPSPSGSNPPGFFRDGFKEDDITQTRQNSMDDAILRRASEASFPTTAETERRPSDYSMTSAPSPQKQSDLSTCDTPENNKREVSSTDNSTDRKRHKPWKEEDMSPQKSPLWADTITGPVNAAETPNDTESPNEADALTSNNLANTPATIPATTLVTAPATHNSNATLPSVRKDKINHAIRLPHKKGQTIIERPGDVRRRKVSTTLARDPKEHVYVHHSDTLLESPTKNIRLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KKC2</accession>
    <name>A0A167KKC2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_102152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286335.1">
        <property type="nucleotide sequence ID" value="XM_018427674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KKC2"/>
    <dbReference type="STRING" id="763407.A0A167KKC2"/>
    <dbReference type="GeneID" id="28988580"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_102152"/>
    <dbReference type="InParanoid" id="A0A167KKC2"/>
    <dbReference type="OrthoDB" id="3039677at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="180" mass="20152" checksum="1D3B084E38DD67C7" modified="2016-07-06" version="1" fragment="single">NLPRSEQYKKENVVLVGLMPGPKEAKTSEINHYLRPLVAELNQLYGSVVMPTIQCPSGALVRAALLLVACNIPAARKTCGFTSHSSTCACNKCNQQFPRLPNSNAVDYSGFVFSEWVPCTDAENCRDAELWRMASSDAQRKRLERENGVQWSELHDLIYFNLVECTVIDLMHNLYLGTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L8S9</accession>
    <name>A0A167L8S9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_171869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287888.1">
        <property type="nucleotide sequence ID" value="XM_018436683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L8S9"/>
    <dbReference type="FunCoup" id="A0A167L8S9">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167L8S9"/>
    <dbReference type="GeneID" id="28997589"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171869"/>
    <dbReference type="InParanoid" id="A0A167L8S9"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF1">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="165"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD69848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="259" mass="28703" checksum="F632752E5986E8B4" modified="2016-07-06" version="1">MFSRLVVQTAAGINRRFPRAVLQARFFTQQHQKQARSRLLSPFFISTTSAIVATGLTFAVMSTQHHDDLLEQKIALNGTADHEVEEATKYLNNMTIVKEARSNKNMFEIEAYSHLNGSAKLHSLTASTLRGKGKVIVAPVIFYNKSMTEVTIVCHLGTELCGHDGIIHGGMLATLLDEVLACVAFPALPNNIGFTANLNIDYRKPVKSDQWVVMRGQLDRLEGRKAYVEAWIEDLEGTKMTEAKSLYVAPKSIIPKIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LGN9</accession>
    <name>A0A167LGN9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GPN-loop GTPase</fullName>
            <ecNumber evidence="7">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_135099</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="7"/>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288449.1">
        <property type="nucleotide sequence ID" value="XM_018429695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LGN9"/>
    <dbReference type="FunCoup" id="A0A167LGN9">
        <property type="interactions" value="590"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167LGN9"/>
    <dbReference type="GeneID" id="28990601"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_135099"/>
    <dbReference type="InParanoid" id="A0A167LGN9"/>
    <dbReference type="OrthoDB" id="243313at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000579">
        <property type="entry name" value="GPN-loop GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD70409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="286" mass="31684" checksum="241EAA16A1273C33" modified="2016-07-06" version="1">MSTSKPSPTETPASTNGKKQPPVILCIGMAGSGKTTFMQRINAHLHAKKTPPYVVNLDPAVGNLPFTANIDVRDTVNYKEVMKQYNLGPNGGILTSLNLFTTKFDQVLDLIAKRADSVSHILVDTPGQIEIFTWSASGSIITDTLASTYPTVIAYIIDTPRTTAPATFMSNMLYACSILYKTKLPFILVFNKTDVVSHEFAVEWMTDFEKFQEALSHDTTYMSSLMNSMSLVLDEFYSHLKVVGVSAVTGNGVEDFFAAVDEAAVEYERDYKPEIERMIKEKVYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LKJ7</accession>
    <name>A0A167LKJ7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_171401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288694.1">
        <property type="nucleotide sequence ID" value="XM_018436589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LKJ7"/>
    <dbReference type="GeneID" id="28997495"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171401"/>
    <dbReference type="InParanoid" id="A0A167LKJ7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="137" mass="15518" checksum="571838CEC4F1AE67" modified="2016-07-06" version="1">MFSASPYIGKQKWILDIGSISVIGIITFLYKSHNAYSSIKQVIFSGKYMGMSVCLKKPSYSGGLYTTGFLVDGGYLSEKIKDVDDPNCIMCDLLEYSFPIIRIWEAHFCLVFDEVGFIPSRITTIIYSKSEPQKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LZZ1</accession>
    <name>A0A167LZZ1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_168914</name>
        <name evidence="1" type="ORF">PHYBLDRAFT_170125</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">NRRL 1555</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289484.1">
        <property type="nucleotide sequence ID" value="XM_018436255.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291614.1">
        <property type="nucleotide sequence ID" value="XM_018435967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LZZ1"/>
    <dbReference type="GeneID" id="28996873"/>
    <dbReference type="GeneID" id="28997161"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168914"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170125"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="155" mass="18276" checksum="B9A71275EF64B44F" modified="2016-07-06" version="1">MHDHRIRTTDALLESHPHYGCVIRIASALRMRKLYLYLITLEKPLDYQMHYLKTINDYSFCDLLENKLFLSHMTTGLRIMLCIYKERLLWQDFVLDNDCLDGVIFIEEGVEDSMIGIVDFERSAKLLLSALPFRIASLSVHFELQYNMNDDPQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M3J1</accession>
    <name>A0A167M3J1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carbohydrate-binding module family 13 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_147432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289719.1">
        <property type="nucleotide sequence ID" value="XM_018431864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M3J1"/>
    <dbReference type="GeneID" id="28992770"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_147432"/>
    <dbReference type="InParanoid" id="A0A167M3J1"/>
    <dbReference type="OrthoDB" id="9895617at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="232" mass="26686" checksum="CA99FE87D9002D9A" modified="2016-07-06" version="1">MAGYSNDFSDGFFFIRSKDRPMAVDVNDGSMLNDAHIIIWPQKHTDSINQLWMHEDGFLLNKKSGLVYGMIDYRRVEYNAKAESNAKAKYKAKYKAKYKAKVKAKVKAKTKNYTDEACNFIKHTYICLVLAGDIKKDKSLVQYARKSGLAYNQRWKYQDGFIFPAAAPHLSLDIRGDHKEGSFIFLNTKMSGVSSQQWLVEPFENERSKQDLELLRPSVKLSINRCSDSKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M435</accession>
    <name>A0A167M435_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_72849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289774.1">
        <property type="nucleotide sequence ID" value="XM_018442732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M435"/>
    <dbReference type="GeneID" id="29003638"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_72849"/>
    <dbReference type="InParanoid" id="A0A167M435"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22874" checksum="DBB98391F00D29DB" modified="2016-07-06" version="1">MNNTDNNFISLLHVMYNELLSLKVGKENAKLEMKVQIKKLKLKMKTSIKDLNLEITALQNQLENRNIPNQHTLPSVSVISSVNTMCKLVSIFREITIKHIFKMTTEDLGIEVASNKKTILNMCTKLICDDMAAHPLVITLGSNPSWGSIPVALKKEICARYANIMKDSDIDFTRCLRNWESTARVAHLWRNCHKRLQSHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MVH5</accession>
    <name>A0A167MVH5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_111952</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292189.1">
        <property type="nucleotide sequence ID" value="XM_018428251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MVH5"/>
    <dbReference type="GeneID" id="28989157"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_111952"/>
    <dbReference type="InParanoid" id="A0A167MVH5"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD74149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="295" mass="32973" checksum="A06A019F40221852" modified="2016-07-06" version="1" fragment="single">GKKRALLVGINYIGSENALNGCISDVLKMKKFLMKSYGFRECDITVLRDDSEDPDLMPTYGNIRTAMGELCRDSQPNDSFFFHYSGHGGSIPDESGDEVDGMDECIFPCDCDEGYIIIDDLMHDLMVRPLCEGSRLTALFDSCHSGTVLDLPYIYSSKGHVKKKSLFRQASAGLFDITSKHKGGALKLLSSFMDLGQDLIKTREVESFHRELNTSAADVIMFSGCEDHEFSTDASVSNESVGAVSYAFMRTLTEKPDQTYQELLQNIRKMTVLKYDQNPQLSSSHPIDLKKKFIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MWC7</accession>
    <name>A0A167MWC7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_144702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292294.1">
        <property type="nucleotide sequence ID" value="XM_018431271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MWC7"/>
    <dbReference type="GeneID" id="28992177"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144702"/>
    <dbReference type="InParanoid" id="A0A167MWC7"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="386" mass="42683" checksum="0E977ED35FFC00C0" modified="2016-07-06" version="1">MYSPSIVPTSPEACHDDALFNGLCNKHSRYGHKRHDGFLNTPPHQALSAIVPDRLSKALFEITPTDILARKEVALSGAIGFRSIFGISNTSTYPTHLILDSKRKATMEQGSHDLDANLRSHGQINGCGGNSDQDMEKSRTPVPTYPAHLIPSLLSKKAPLPTINFLSAENSSNIVFEELLEDFIVKSTMYACPEYDPTDKCAHNYISTKPSMDTSQSNNVSDSATFPSGGESCWPTPCLSDVSSVFDISEQSPLIHTNSINNTITTNHNIRDFDLFGPTHLPSPKKPKYKNLTSPFQAKSSSCFILPARTTNKRKRMRDASVGITSKRHRCSLCSYEGAHTGNFNRHIQTHYIIRNKVACSLCGSPYANKYNLSRHVCKQSVINSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MY04</accession>
    <name>A0A167MY04_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_167873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292504.1">
        <property type="nucleotide sequence ID" value="XM_018435737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MY04"/>
    <dbReference type="STRING" id="763407.A0A167MY04"/>
    <dbReference type="GeneID" id="28996643"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167873"/>
    <dbReference type="InParanoid" id="A0A167MY04"/>
    <dbReference type="OrthoDB" id="9942608at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14372">
        <property type="entry name" value="CUE_Cue5p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000064">
        <property type="entry name" value="Similar to CUE domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041807">
        <property type="entry name" value="Cue5/Don1_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461:SF5">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="60"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD74464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="782" mass="86935" checksum="A11B659D01F58F7F" modified="2016-07-06" version="1">MLLIKDMLFRAMSEANDIHQPHLTETQATQSPTTSQQSPESQEQDDSSPVAPSAPPIQQEPPAQLQTLKEAFPSVEVDVIEAILESQGGQLEAAFEALLAISDPNYRPEPTNNIPPQPAPAPHPAPHPPVQQTQPSEYYQPQREIPAQHENLQSNNNTNERIPPPKPPRPQQQRPNNFTQQSSGLQNQPYGYWAGTQDPSIQTRSQISVEEQLRMDEEFARQLAMEDANESDYQYQRKPTPETRIPKTATAEKEFPVIKEKVIEVGNAAKKKVIDLFNQFKASRNNMSSSGSSIPTTNVHYRGLPSDDGDDLLAGDMSALHLSDNDVYAQTRGVVRPRTTPENQTYIEEDQEDQEDQGELRSNIIHVNRPFVPPVKTQKYNDAWSTEEQLRSDEALARRLANEDMIERGSLGTNTSVTGIRAPSPSQSTTPTKASEDPVSNPEKEIPESSPIKEQDNKSENKAKEEEDVPYVIGDDDSDDDLVDEDEDTAVKEHPRNKYEQKPHKHFLFSISIMNTHPENIVAVPSIHQDNRVQISEQACAHLLDNAQQCLSSPGHPMTTLSPNQPFTFSPAHHEIPLHFNIGSHLTTPEEGQSLINHPLLPAREQPSGPCTPQPSSSSGAPDILHQEQILCQQQSQSPHNDLKQEQLQHASRSPSQQTPQHSGNMLEHHYGQQLSLALATATQQNQTVQLQHMYAGSQTLDTHSPMPALSQDLINQHSQAEIEHMAMLVKQNSTPLTQGAHLPVTQSVESPHQPALVPIHTPPVAMHSHPNPGREPQELNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NN62</accession>
    <name>A0A167NN62_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_154953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294360.1">
        <property type="nucleotide sequence ID" value="XM_018433367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NN62"/>
    <dbReference type="FunCoup" id="A0A167NN62">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167NN62"/>
    <dbReference type="GeneID" id="28994273"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_154953"/>
    <dbReference type="InParanoid" id="A0A167NN62"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000043">
        <property type="entry name" value="General stress response phosphoprotein phosphatase Psr1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="1">
        <location>
            <begin position="11"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="190" mass="21619" checksum="6A2AA1F3ED4668DC" modified="2016-07-06" version="1">MLWLLDPIAPKDKGRKCLVLDLDETLVHSAFKVVPQPDFVVPVEIDHQVHDVYVLKRPGVDAFMKRMGEIYEIVVFTASLSKYADPVLDIFDRHNVVQHRLFRESCFNYKGNYVKDLSQLGRDLSKVIILDNSPASYIFHTANAVPVSSWFNDPHDSELLDLIPFLEDLATVDDVTDILDNTIPGPFSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NPA2</accession>
    <name>A0A167NPA2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_109842</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294424.1">
        <property type="nucleotide sequence ID" value="XM_018428139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NPA2"/>
    <dbReference type="STRING" id="763407.A0A167NPA2"/>
    <dbReference type="GeneID" id="28989045"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_109842"/>
    <dbReference type="InParanoid" id="A0A167NPA2"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14081">
        <property type="entry name" value="STKc_BRSK1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="59"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD76384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="372" mass="41356" checksum="08F96264FA53241F" modified="2016-07-06" version="1">MPDYSYRSSASSRRQSVASPVSILPSNKSSKSIRDRRRSSGTLSTHSVSQKARKTIGDYYVGKTLGKGASGRVKLGIHRQTGEQVAIKIISKAHLAANPAIEKAVRREIAIMKLIRHPNVMSLVDVIDDAALPDLHLILEYVEGGELFEYLVSKGRLGEPEARHHFQQIILGLDFCHHHLICHRDLKPENLLLDAQNNIKIADFGMASLQPAGSMLETSCGSPHYASPEIVAGMPYNGSASDIWSCGVILYALLTGHLPFDDENIRQLLKKVKSGKYTMPDDISRNAQDLIRRILVVDPTKRLTMEQIMAHPWFRESELMNLSALPVPPTENEIGRPVNSPSDIDDRLLETIKFLWGETDDEVVIEALVSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P028</accession>
    <name>A0A167P028_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_99862</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295018.1">
        <property type="nucleotide sequence ID" value="XM_018444111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P028"/>
    <dbReference type="STRING" id="763407.A0A167P028"/>
    <dbReference type="GeneID" id="29005016"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_99862"/>
    <dbReference type="InParanoid" id="A0A167P028"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="4">
        <location>
            <begin position="1"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD76978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="289" mass="32844" checksum="192C04FA40C31875" modified="2016-07-06" version="1" fragment="single">QFNVMVVGFAGVGKTAFLRTFLEALQHLHGASPETDDEITALQPTKLPSTVSVNIDSGGERLTLRLIDTPGLSTGYQMDKELQDILGYIEHQFDLTLTEESKVKRNPKAVDSQIHACLYFIDPSKTKLDEHDVRIITRLSNRVNVIPVIGKADTLTAAQRRRLKPAILQSIYNEATKIPLYGIPEDEEEDEEDEEDEDDKETQCVLDYLHQIPFGVIAYEEDPETGKPLETQNSAIKIGRDYGWGVIDCLSDKDSDLYSLMEVLLHTHRDILKSETIERYYEQYRTEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PG57</accession>
    <name>A0A167PG57_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_141713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295889.1">
        <property type="nucleotide sequence ID" value="XM_018430649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PG57"/>
    <dbReference type="GeneID" id="28991555"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141713"/>
    <dbReference type="InParanoid" id="A0A167PG57"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD77849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="86" mass="9669" checksum="9663491FB9064FF1" modified="2016-07-06" version="1">MSKPVHSKNEIPRSNTGLTINPSKAYSRSETRDKLTGLTIFHGGLFRQSQAIKNRFPSRATGTPRLNEHMLIIFCMLLVSSAQVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PI22</accession>
    <name>A0A167PI22_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_185692</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296007.1">
        <property type="nucleotide sequence ID" value="XM_018439124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PI22"/>
    <dbReference type="FunCoup" id="A0A167PI22">
        <property type="interactions" value="612"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167PI22"/>
    <dbReference type="GeneID" id="29000030"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_185692"/>
    <dbReference type="InParanoid" id="A0A167PI22"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01417">
        <property type="entry name" value="Ribosomal_L19e_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.240:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1650.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_eL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023638">
        <property type="entry name" value="Ribosomal_eL19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033935">
        <property type="entry name" value="Ribosomal_eL19_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006343">
        <property type="entry name" value="PRK08570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00526">
        <property type="entry name" value="RIBOSOMAL_L19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="6">
        <location>
            <begin position="7"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="161"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD77967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="192" mass="22096" checksum="D16ED0BEF310C1AB" modified="2016-07-06" version="1">MGLSGVSLSIQKRLASSVLKCGQRKIWLDPNEVNEISNANSRANIRKLVKDGLIIRKPEVSHSRFRVRVHAAAKRLGRHMGYGKRKGTADARMSSQVIWMRRMRVLRRLLAKYREAGKIDKHLYHSLYLKSKGNGFKNKRVLMEYIHKAKAEKLRAKTLNEQSEALRAKNKALRERRKLKAEEKKASIGAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PIB9</accession>
    <name>A0A167PIB9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_68514</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296026.1">
        <property type="nucleotide sequence ID" value="XM_018441966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PIB9"/>
    <dbReference type="STRING" id="763407.A0A167PIB9"/>
    <dbReference type="GeneID" id="29002872"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_68514"/>
    <dbReference type="InParanoid" id="A0A167PIB9"/>
    <dbReference type="OrthoDB" id="29596at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03281">
        <property type="entry name" value="ABC_MSH5_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="6">
        <location>
            <begin position="563"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD77986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="765" mass="86511" checksum="E4D33D36D1FB2CAC" modified="2016-07-06" version="1">MAIQWKNGKLGCVYYDHLFQTLYLMEDTPESTRFEFVRQYECIRVEKRSFKEFDSRKGRISLLNWYIHQSTSQDFHSRSQAAEDYSNNNNNDDDDDDDSKRTQAMIRLTGLINPQSHITIGCAGALLSYLQQIEDCAYSTTSSGSRLYPLSLKTFTNISMILSKLCVQINAETSKSLSLFEKDTHPNMHQKRGKEGFSLFGVLDQTVTPLGHHLLRQWLQRPSLDISLINTRHLSVEYFSGHGRAEMVKELVGYLGNIKNVARLLANIREHRATHNEWNQLLNFAYYGIRINGLFKHSPQLPIISKIQAIDKHLLRTLGTDINDTIDFGQSSTENRVVVNTRINKDLDLLKKKYEALDDYLLSITQDMSADMPIGIGAMLNVVYFPQLGFLVTLPYTITSYPKDFELQFTTGENLYFKNPKTKELDQDIGDVHAMMIGKHPIQELWVDRFIPNDTRLRQASFSAEQQSTIDQDGVGPGKVMVLSGANYSGKSVYLKQVALITFMAHIGSFVPASHATIGLTDRIFTRIQTSETISQARLQVQSAFSYDLQQLLQAITYSTSHSLVIIDEFGKGTSSSDGIGLFCAVLEEFLSKKARCPKVIASTHFHEIISRQLLRPDGSIGFYTTQIIINQQTNGSESEPCETDRVKDIVFLYQIVPGVGLSGSYGAWCASLAGIPPKTVNRDKKESKGDNLIFTGVALYLSDRFGSQQPIEPLESEREFGIFKQLEDYSEEFLMIPVRKDSQGLTQHRDLIKSISDLFSINQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PYH1</accession>
    <name>A0A167PYH1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_179698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296817.1">
        <property type="nucleotide sequence ID" value="XM_018438196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PYH1"/>
    <dbReference type="GeneID" id="28999102"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179698"/>
    <dbReference type="InParanoid" id="A0A167PYH1"/>
    <dbReference type="OrthoDB" id="10339402at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="563" mass="63642" checksum="0BB046B442584F32" modified="2016-07-06" version="1">MTMFCSSFSKIHPKDYQNTTLCIYLILCFMVVDCLAAPVVVENILSPTEIAAITMMRTFFLSYLAHAKTVRPDSTTIRAATFYKRVSALAFPTSGIYDAVGSMIRVFYGDKILGIESFNRFLKKKMVSRNVFDYRHQPYVCSEISIDTPTLKKDFQYNSHEEHSNTTPYISYLAKDPSKQWVDQYRETLAEFNSKKNDNAPFLAALLHSIGPLRARKVRHCILNGGVFIGYNEYNGTNCMRRYRLTSKDMILAGSGAMCRYQVPVCSSAVRYLPVDMINELQAASFIDSTSYFQVMITLFQLGYTLYECIRGIGNRWSKIVMIVFTIMSVFQTMSLMVLHTQVAAFSIRCKNEEKFPECPLIHDSRCKAGKAKNCSKDAPPDTPTDTSTDLLKSTSFAHKFTFISSLMERNWVFCPSEDTDLNRVRRNAAHDVMSKSGVSPAMINELFGDEKADLVDISSHPGGWWEIVSFMLGSASPFLLGIWAGYGASATVMSSTIGWISISFGYSYTFIRTFYPTYFINFRFKDLQTSLVVLSYALMSSFGIAYIIQITIKGYLFSDDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PZF1</accession>
    <name>A0A167PZF1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_130942</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296849.1">
        <property type="nucleotide sequence ID" value="XM_018429393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PZF1"/>
    <dbReference type="FunCoup" id="A0A167PZF1">
        <property type="interactions" value="173"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167PZF1"/>
    <dbReference type="GeneID" id="28990299"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_130942"/>
    <dbReference type="InParanoid" id="A0A167PZF1"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000075">
        <property type="entry name" value="Probable UDP-N-acetylglucosamine pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD78809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="502" mass="55339" checksum="48F717D5451C9720" modified="2016-07-06" version="1">MTITETIQASHVDALKARFAAAGQEHVFHFYNELSAEDQAKLYKQLETIDVERLNVIYQKAIQGAEAAGEQDASLEPLSGEVFESVLNSSAEKLQEWETIGLTQIAQGKVAVILMAGGQGTRLGSSAPKGCYDINLPSHKPLFQLQAERILRLQEIARQYKKPGDGVDSIIPWYIMTSGPTHGPTYDFFKKNNFFGLKEQNVIFFEQGVLPCLTMEGKIILEDKAKVAMAPDGNGGIYAAVQNKGVIDSLKERGILYTHCYCVDNCLARVADPVFIGYSVSKGTDCGVKVVRKEQPEEPVGVVCLRNGKYGVVEYSEITEELTQRRNEDGSLSFGAANIANHFFSTAFLERVPTFAAELEYHIAKKKIKFVDLETGEQISPKANSGMKLECFVFDVFPFAHSLSVLEVDRKDDFSPLKNAPGSGADCPETSRRDIVAQHVRFIEAAGGKVVGEHSDDLDKLHFEISSWVTYSGEGIREIVQGKTITAPAVIETREDLIRLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QN82</accession>
    <name>A0A167QN82_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_163014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298001.1">
        <property type="nucleotide sequence ID" value="XM_018434719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QN82"/>
    <dbReference type="GeneID" id="28995625"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_163014"/>
    <dbReference type="InParanoid" id="A0A167QN82"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD79961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="110" mass="12806" checksum="742A9909FDF2AF1B" modified="2016-07-06" version="1">MSHIPGVLFFWKDPERPIDMTLLQSDQSKSFGKEEHLCYWEIRLTGIAEDIILSFSLTLRFSSNQYSFTTILKIVKIIISYCWNIGEVGMWYFRALGLPTKLAPYFSDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QQ28</accession>
    <name>A0A167QQ28_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrofolate reductase</fullName>
            <ecNumber evidence="2">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_102050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298088.1">
        <property type="nucleotide sequence ID" value="XM_018427660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QQ28"/>
    <dbReference type="STRING" id="763407.A0A167QQ28"/>
    <dbReference type="GeneID" id="28988566"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_102050"/>
    <dbReference type="InParanoid" id="A0A167QQ28"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046452">
        <property type="term" value="P:dihydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069:SF3">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00070">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="7">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD80048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="200" mass="23096" checksum="0FF6FE3C25CA9967" modified="2016-07-06" version="1" fragment="single">MAAALSDTRGIGYKQDLPWYIPADTKWLNHVTTKKYVDTPLNRVDDQDWHNVVIMGRLSWESIPMRGIPMEDRFNIVVSRNPDYNIYAVDKFRNVSLSNSISQALSDGIEESQKTGGRIFVLGGEKVYEEAMVLPQSTHILLTLIYTKEPIECDTFMPQIDLRIFRLASHEELEAFIQEIVPEGIQSHENLDYEFLLYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R2I8</accession>
    <name>A0A167R2I8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1754-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_61751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298738.1">
        <property type="nucleotide sequence ID" value="XM_018440851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R2I8"/>
    <dbReference type="FunCoup" id="A0A167R2I8">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167R2I8"/>
    <dbReference type="GeneID" id="29001757"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61751"/>
    <dbReference type="InParanoid" id="A0A167R2I8"/>
    <dbReference type="OrthoDB" id="205403at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013865">
        <property type="entry name" value="FAM32A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282:SF6">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08555">
        <property type="entry name" value="FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="13092" checksum="41D6D07F0A2D2754" modified="2016-07-06" version="1">MSAYDQVSKGSLKFKGSDSPIKKKKKKAKSEREKFARAIQDEADGQKQEDSAAHRVTVVEKTEAERKFEETKLKRQMERVAKAATRSHKENVYEFNKKLEHLSEHYDIPKVGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R6F3</accession>
    <name>A0A167R6F3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAM192A/Fyv6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_76903</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298998.1">
        <property type="nucleotide sequence ID" value="XM_018443198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R6F3"/>
    <dbReference type="STRING" id="763407.A0A167R6F3"/>
    <dbReference type="GeneID" id="29004104"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_76903"/>
    <dbReference type="InParanoid" id="A0A167R6F3"/>
    <dbReference type="OrthoDB" id="75720at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039845">
        <property type="entry name" value="FAM192A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019331">
        <property type="entry name" value="FAM192A/Fyv6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495">
        <property type="entry name" value="NEFA-INTERACTING NUCLEAR PROTEIN NIP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495:SF0">
        <property type="entry name" value="PSME3-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10187">
        <property type="entry name" value="FAM192A_Fyv6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM192A/Fyv6 N-terminal" evidence="4">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="104"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD80958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="210" mass="23403" checksum="8ADFE972391D7CE5" modified="2016-07-06" version="1">MSFNKSFVSRGVVEGEEEKLDGSEVQASAPIQDYDPRTLFERLQEQRNIKDEEFHEATRLSNLIKLVDADEAEFYKTLSDEQKSLDEKRKMKEKDELETYRKAVEQARLTAPPPPTLAATVSATSVTMTQTSLKSTKRKSVSSPFQGLVVKKKKIDGQDENSEPKSTPTSISTPKAAESKPKVVESKPKETLNPLGSLVAYSDDSSDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R8T4</accession>
    <name>A0A167R8T4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_103736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299159.1">
        <property type="nucleotide sequence ID" value="XM_018427786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R8T4"/>
    <dbReference type="STRING" id="763407.A0A167R8T4"/>
    <dbReference type="GeneID" id="28988692"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_103736"/>
    <dbReference type="InParanoid" id="A0A167R8T4"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8910" checksum="96B47A1C92EE06F5" modified="2016-07-06" version="1" fragment="single">IEESLILNSESDQYVFSHRNKFDVVVYYDQSSQGIHDESETLRNLKLAIYQLEFTKKLGRVPMLLAGGFDAWQEKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167RF41</accession>
    <name>A0A167RF41_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_139045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299539.1">
        <property type="nucleotide sequence ID" value="XM_018430141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167RF41"/>
    <dbReference type="STRING" id="763407.A0A167RF41"/>
    <dbReference type="GeneID" id="28991047"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139045"/>
    <dbReference type="InParanoid" id="A0A167RF41"/>
    <dbReference type="OrthoDB" id="2256373at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="145"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD81499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="312" mass="35840" checksum="A84593F8CE53CC8D" modified="2016-07-06" version="1">MSSDTLNTFDFEIILQKTSTKENSRQLASSIRAFYTIIDSANKVISLEAARKDKVKNNEHTGIDLYLWEFKHSIFHVSSNLSATVLIRFEDKIRQLLCPTPSIDLSSYADSPDFSDVTIKVIKSESNDDSDSRKRIQEPNKYMYQTLNICIEKLKSRDFRCHKVVLAGASPWFKALFKIKMSDSNSKDVTIRGISPEMFEKILVLIYSSEYNVKDLDEASKILKVAERIEISTLCNLIFAYLKSNINNKTNYRRKDIETACKNFIKHNAATFVRSKEIIAFDSESVIKILETNNLSPPVNEEKLYDAVLSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N4A9</accession>
    <name>A0A162N4A9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_68952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286438.1">
        <property type="nucleotide sequence ID" value="XM_018442033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N4A9"/>
    <dbReference type="FunCoup" id="A0A162N4A9">
        <property type="interactions" value="470"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162N4A9"/>
    <dbReference type="GeneID" id="29002939"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_68952"/>
    <dbReference type="InParanoid" id="A0A162N4A9"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055555">
        <property type="entry name" value="PA-PLA1_DUF7131"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057826">
        <property type="entry name" value="WWE_C20G8.02"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF10">
        <property type="entry name" value="LD21067P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23465">
        <property type="entry name" value="DUF7131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23463">
        <property type="entry name" value="WWE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="2">
        <location>
            <begin position="550"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="693"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD68398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="798" mass="89258" checksum="166541007443DBA1" modified="2016-07-06" version="1">MSSPDSVFQKPGPQPTTRRSSVIPDDDVPNLAVRWFHAIDSPIVDPISLRRAKTLPRSATTPIPKLRTPSKNWMPFSKRDSIALENAYQLKSPNSNSSVTVNEDHLFEVDVARRIISPVYWEGPTFEVRRATWFIQGDGFKWIPCEEVLAEQIELGYYKHKPYLVPVEEVDPLTDPSESNGDENANQAALEQKRLEKTLSENSVEKQWNLLGSYIGQYIVYTGPSTAWLLYDTTGGKIAKTIITRLTNNQNLGGTRLLRGYPEVEKQSQSTPLTHSAPIPHKDVNAVDISELAETQSRAIKDRVEKDRSFRERDTNPGDGKCKEKNKANEDMHREANDYLNEDSEEELRPIDHLIFVVHGIGQRMAERTGQNFVHDVNMLRQTLKTAFPTAVSTLPGDTPVNGIQVLPILWRHEIQFGMASEEEEGKESDLGMPDGDDGSPTLDEITLDGVPNIRMIVSDVLLDIPLYMTHNYRDQMAQAITNEINRIYATFLKHNPGFEEKGKVTILGHSLGSLLAFDILTSQPIPGSTSLFSKITDNLMGSGEKKIPLSFPVQNFFALGSPLGIMLLLRGLKIASRKSLEPGQLPSDQSPVTFCYPAVENLYNIFHKSDPVAYRLEPLIARHYSVKLKPEQIPYIKGGLKSVIDAGFHVGTDIATRAGAMYESIKSGFTSNVFMRGLGLARPYASESDINSHSSPHLTASSSEPTDMSRSLQHQQHVRPNKPTDRSVQNPRSIDSSGAKKMLQLNPSGRVDFCLQEGILENPYLSALSVHLCYWQDLDVAAFLIREVYRKHSQHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N6N5</accession>
    <name>A0A162N6N5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_175318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441004">
        <property type="protein sequence ID" value="OAD66264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284304.1">
        <property type="nucleotide sequence ID" value="XM_018437468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N6N5"/>
    <dbReference type="GeneID" id="28998374"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175318"/>
    <dbReference type="InParanoid" id="A0A162N6N5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="130" mass="14748" checksum="2747318D2445F55A" modified="2016-07-06" version="1">MNEKGKDSDLWGIDYCNHSPKTGATNKFFVNLFPIELFLNFSYSNIRRIWSIFLRTVAYHAAEMFVRTYSEELLNVPPPTGLNEELSLTEDVSDAQTMFDSAVKADDAYGVLSDETIGTYKKTAIFEPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NEX2</accession>
    <name>A0A162NEX2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_188518</name>
        <name evidence="13" type="ORF">PHYBLDRAFT_56099</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286971.1">
        <property type="nucleotide sequence ID" value="XM_018440208.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286974.1">
        <property type="nucleotide sequence ID" value="XM_018439524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NEX2"/>
    <dbReference type="FunCoup" id="A0A162NEX2">
        <property type="interactions" value="293"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NEX2"/>
    <dbReference type="GeneID" id="29000430"/>
    <dbReference type="GeneID" id="29001114"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_188518"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_56099"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000008">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="14"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="12">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD68931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD68934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="131" mass="13811" checksum="B138742F6B44137B" modified="2016-07-06" version="1">MSGGKSGGKSAAGAKSQTRSAKAGLQFPVGRIHRLLRRGNYAQRVGAGAPVYLAAVLEYLAAEILELAGNAARDNKKSRIIPRHLQLAIRNDEELNKLLGHVTIAQGGVLPNIHATLLPTKTKKAGASQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NHE1</accession>
    <name>A0A162NHE1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-dihydrouridine(47) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="3">1.3.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">tRNA-dihydrouridine synthase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PHYBLDRAFT_111874</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>5,6-dihydrouridine(47) in tRNA + NAD(+) = uridine(47) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53364"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:53366"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>5,6-dihydrouridine(47) in tRNA + NADP(+) = uridine(47) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53360"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:53362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="18">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="19">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Dus family. Dus3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.89" evidence="3"/>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292328.1">
        <property type="nucleotide sequence ID" value="XM_018428245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NHE1"/>
    <dbReference type="FunCoup" id="A0A162NHE1">
        <property type="interactions" value="495"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NHE1"/>
    <dbReference type="GeneID" id="28989151"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_111874"/>
    <dbReference type="InParanoid" id="A0A162NHE1"/>
    <dbReference type="OrthoDB" id="259935at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102265">
        <property type="term" value="F:tRNA-dihydrouridine47 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000067">
        <property type="entry name" value="tRNA-dihydrouridine(47) synthase [NAD(P)(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="21">
        <location>
            <begin position="30"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OAD74288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="379" mass="43285" checksum="C5D8861D338237C5" modified="2016-07-06" version="1">MSVEAEKPLGPIDTERPYKKLIDFRNKTYLAPLTTVGNLPFRRICKEYGVDITCGEMAMAKNLLHGQQSEWALTKRHASEDIFGMQICGSKIDQVVKACELINNETDVDFVDLNMGCPIDLVFKAGAGSALPESRGKMVKMIKGMQTVLDVPVTVKFRTGLKENTPTAHKLIPRFEELNVGLCTIHGRSRMQRYTKSANWDYIRSLKQEFTKIPLFGNGDVLSFEDYNNCKAQSGVDGIMIGRGALIKPWIFDEIKEQRHWDISSRERLDMLKRFCNYGLEHWGTDSQGVNNTRRFLCEWQSFLYRYVPVGVMEVVPQKLNERAPPYFGRDELETLMASPKAADWVKLSEMLLGPAPEDFTFVPKHKANSFEVMIYIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NKV9</accession>
    <name>A0A162NKV9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED5</name>
        <name evidence="11" type="ORF">PHYBLDRAFT_181094</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293198.1">
        <property type="nucleotide sequence ID" value="XM_018438416.1"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NKV9"/>
    <dbReference type="GeneID" id="28999322"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_181094"/>
    <dbReference type="InParanoid" id="A0A162NKV9"/>
    <dbReference type="OrthoDB" id="5549158at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014801">
        <property type="entry name" value="Mediator_Med5_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08689">
        <property type="entry name" value="Med5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="239"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD75158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1293" mass="144687" checksum="6C91CF75B0316FC3" modified="2016-07-06" version="1">MTAGAIEAVLRYAYVHGYSCEQWAEPTRQCFQRVDHKLDKELCDVLLNQIFCLIRVADPLLESYLTFATTGHKDLTSPLLPGASLLDPIFISPKVLLQSLAQYVDSTAGRNPRQWAYLLRLVSVLLAPLDAEKIVNSVHQQKIVDSDQPSQDDWFDVLATVFVMLSRLVAVGLEHESRDREPKPGPRLVRSAISFQRGNTQPGDISTIWPSSSNYLSSQTSAYDPEATIDEDSFGHEALEEEKEQDIKSSAKRRRTGAGDGIGAGARNGSGNEEDEDEEDEEEKIERSNAIMASQIMIDLIEKKSAKRMFEVRQNQKRQHGHESTSEEPWATCQEILTGPSLHSSSKKSGVGSLRQNPHVQKLLILIGRLTDRNLERMMAVHMKYHELEDEGTARAMPSAGLMGLLYHVVQIRPTLDDETIVDHLIKLQTIKGSFDESFYLELWFTALTGLREASFGTSCQTQSFESKLEKNTVDRKEKSCNNAIATNRLLWRSLVLVKLPHLIKMMQKKSEAKASRRPWKEHKGGFKDDVVEKELNPLESSLLELKAFTGLLNACSPPACCSDFYAPSSQSSDLVDKLGRGSTEDEDDALMTLINTISDDFNTPTVTKAIRSISTESIFLNMVHVCESYGFIRPHVVRILSCSSSAAGGSGSATVSSSVNKTECDTTTDLMDTDILDMDSPLGNNNSNSKTHRNLMEDPEDCSMDSIEIIRQNIEARMESILIECSMTAVRELLEISIVSLVHLRRIIDFLIDLLQQKASLGDIETIAQICSAMNAYPCIVDLIIQLYSPLAFMGPFEELCNGWSPSDSGMFIDEEEEVKSAKSLYNEFGTIWIFVSFVVDRFNLIRDLDRVFRVREGFCYQFFSQGPVVYGIDASVPDMEVWVSKWQNALFENDVTGELLREMTPQRLLAIGPTIIKRVMMSFEEDEMGVSLLPSVLDYLQEPYLHFTLGPILMLLCDELMSTQYRTALMCLDRLIIEGNLPELLVRQCGGVILGSLESIAGENQTYNNGENDAEENERKRARMNRIKTRVESIMEIEDSDARFPPTETVTTRVTRHSLFSKTQEMFRAIVKGGRSMFMRDMDADTHALWDQSKGTTQMVAHYLDMVLFQTALEMGGPRWFISMIVQEVLEAGKSGGAVRAAELGSCLIAIPLSFSSHGHNGCVYLLQCLLQDILPSSLRQSAANNGSFFQGQTLGVFTSDCLVLMHGRPLDDKLDDTDDRMVRALGRIFLNSLGMEGHETSQPSEADVMECGQFAEWTGDITKSAVWRGFIKGLMSNPSINDAWPDAFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NPK1</accession>
    <name>A0A162NPK1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_162168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299614.1">
        <property type="nucleotide sequence ID" value="XM_018434579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NPK1"/>
    <dbReference type="STRING" id="763407.A0A162NPK1"/>
    <dbReference type="GeneID" id="28995485"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162168"/>
    <dbReference type="InParanoid" id="A0A162NPK1"/>
    <dbReference type="OrthoDB" id="3248986at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD81574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="756" mass="85829" checksum="B17A01AB63379AD7" modified="2016-07-06" version="1">MNSTTKTYTVMCTCSSCTKNAIGRILQNAQTFKRHNNADKLLDIGPKNRVNTEVVEEETDIEMIDVSETSIDYEDNYSIASAKTTLQSVPFLREDEIFQFEESDVETTSLASDNDDSDSSDESEDENEVEVASVEDFEDMVASEILTFVVASLKIHEMSQTSQFMALFGVIFQTFYLVQAGGTAMLKFFRHLLVAFDKDTDLPLTIDALKTMTSFNFMTKSILKYTVCNKCFTIYLPGNHQPNCTFEKYTTTPPTYCGNPLFSDTKADRTIPLMVFPYNSLKNALAQHFAKLGFEHQIENATKAEMWFCAESDAERAVLEKQHGTCFSKLHCLHYFDPVQCAIVDPMHNLFLGTAKHMISVWKDLRYLPIAVLVRMQRLADGILVPPGYAVLSTKIESDALPEDDYKNWTLFVKACQKLTSPSVTYSEIDSAHQLLGEFGKECETLYGESSITPNMHLHMHLHESMLSFGPVYAFWLYSFERYNGKLKNIKTNRHNGLEVTFMRVFLEKALIEFLEGVAQVKSNLDSSSPLNLDAGHPPALLFSLAIFQQAATNPWYNVTGSEALPPTTLPIKLQPLTMMKNDHYQWLFEFYVKAYQSTSVSFCVVGRIPIGEDVFVNNRIQKVKKISLLGQEYCSGEKKKRGSFVRVLFLERTNDNVSEFPGQIEYLFTHTIKISGVKRVSMFAFIKWFPTYHSSSYQPLADQGLQLWDKGFMEEDASCIVPVHRLHLCFALTTHKMQSGTQKHLVIPLPRKVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PLW4</accession>
    <name>A0A162PLW4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-hydroxyanthranilate 3,4-dioxygenase</fullName>
            <ecNumber evidence="8">1.13.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">3-hydroxyanthranilate oxygenase</fullName>
            <shortName evidence="8">3-HAO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">3-hydroxyanthranilic acid dioxygenase</fullName>
            <shortName evidence="8">HAD</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Biosynthesis of nicotinic acid protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BNA1</name>
        <name evidence="9" type="ORF">PHYBLDRAFT_56685</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:17953"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:77612"/>
            <dbReference type="EC" id="1.13.11.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the 3-HAO family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.6" evidence="8"/>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288196.1">
        <property type="nucleotide sequence ID" value="XM_018440222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PLW4"/>
    <dbReference type="STRING" id="763407.A0A162PLW4"/>
    <dbReference type="GeneID" id="29001128"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_56685"/>
    <dbReference type="InParanoid" id="A0A162PLW4"/>
    <dbReference type="OrthoDB" id="204928at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000334">
        <property type="term" value="F:3-hydroxyanthranilate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06123">
        <property type="entry name" value="cupin_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00825">
        <property type="entry name" value="3_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010329">
        <property type="entry name" value="3hydroanth_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03037">
        <property type="entry name" value="anthran_nbaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009763">
        <property type="entry name" value="PRK13264.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497:SF1">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06052">
        <property type="entry name" value="3-HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD70156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="169" mass="19628" checksum="A709BF5402319055" modified="2016-07-06" version="1">MLLPPINFKKWVEEHSDYLQPPVNNFLLFKGKDTIIMVVGGPNKRTDYHINETEEWFYQVKGSMTIKVVDDGVFKDICLNEGDMFLLPPKVPHNPVRYQDTIGLVIERVRLPHHTDSLRWYCEGCKDILYEESFHCVDLGSQLKPIIERFATSKKLRTCKKCGVLNSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PMZ9</accession>
    <name>A0A162PMZ9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">STKc</name>
        <name evidence="14" type="ORF">PHYBLDRAFT_148392</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288516.1">
        <property type="nucleotide sequence ID" value="XM_018432078.1"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162PMZ9"/>
    <dbReference type="GeneID" id="28992984"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148392"/>
    <dbReference type="InParanoid" id="A0A162PMZ9"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF5">
        <property type="entry name" value="HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="27"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="1832"/>
            <end position="2061"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="2294"/>
            <end position="2417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="219"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="482"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="880"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2498"/>
            <end position="2610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="883"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="2498"/>
            <end position="2552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="2562"/>
            <end position="2610"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="9">
        <location>
            <position position="2346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD70476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="2627" mass="296753" checksum="624599EA34C40FFE" modified="2016-07-06" version="1">MPHFKTEKSHKRKHSQHTNPLLPRPSFQGNHNINYGAYTIRIPNYTFDQPKLLLDFQHIIKTSDQLSVFVKLSPYALRLEREYYMARRLYTLPDGPHYLSNVIEMVSLAHDGLAALIYTAETPNLELPTTFENIESFMTFAIFACRSLHFLHANNIIHGELRPSSFQTNNSKDITRIWNFGSGMRSYEDILLTGPGWKRSAATATSSTATTGTTTAVISETEPEIETETEIETETSKTSSLLLSSSSSTTTTTTTTTAAAAAAATATAAATATATATATTIIKKKSVKKASNVIKHQQPNQIEDPIEPRTFARLAASKSVQHTLAYLSPEQTGRTSTVVDHRTDLYSLGIVFFVLLTGQMPFEGSAVDILQAVLTRNVPPAHTIRIGVPPVMSLMIDKLTRKVVDERYNSAYGLLEDLLECQRRMKCPDPAESLVFFPLGLHDIYSIFQFPSHLFGRDHEIETVRLITRRVSCTHALEMEKRSATTVAEKDKKEKDEERGQDDKDKDKDKEEEKVLCIPRQAMRDTKTASEVIVIMGPGGVGKSVLVTMMHTQARQHGYLASSKFDSNQKRPYNGLLRCLSSILRQLLTEPESVIRDFYTDLKEQLGPQFCNVWLMVDRVPELKPIFNGEEPDMPQDDMLGGNSESRFHAVFLSIIRTIAATKMITLCLDDLHEADEPSLHLISTLIASRITLLIILTCRDNHDLPQSVLNIIQCTADEAQRIRINLGPLPRNAVTKLVSQTLHREPEDVEQLSELIFRRTRGNPFFARQFMMMMKRREDIWFNWDAKQWQFRLDHATQNLYPQQQQLQEQQLQQQQQQQQKGEGSKINSKEICHLVSHLKDMDPHAQQFIMWASLLGSLFDFRQVQWLMMTVDLSGDEADQAGTSTPTSTSTPTPTPTTSVAVVSGPSSASSLEEDLPFLFVDPAIDLHQDDPRGGQAMTGLQVALQENIIVPKLGSEFQFIHDRYYQAAAMLVNPDHVEHMHLRIAQMLLVDPAADIFLTADHVVKSLELVKLLPDRSKYRQILMKAGDEGYRSGALQMSSIYYNTTLQLLSETPWKQDGPDATYEETLSLYMKLTEMSWRNSERDQASCFLQTIMHETDNRPIDGAYALRFQARMYFEQQRHHDGIGTILKALGALGITYITSDHLSESQVLELYTKVRSSIEELGDNLMTIGPCTDPRMLAAMALLYEACTGAYWISPLLVDFMALCLVRISLRYGFGMASGGGLIGVGCTAARLLQVQFGARLGQLGMAISEKYAGNSEIARGIITYHVILAQWTTGCHYRDLIYQFQRAYKFAIAGGDKMHSALALFHASSTLLYTSFNLSEINFHIHRSIEECLDDSSQDAYTLNISLWRTILAFQGKTTVSEPGCQLDDPPHKKNPFREEAFVANVYRKKAADTGFKILETSLNHPSHRHIGIALYYHSLSMIACIRDTEIDDSVRKMYLDQVAKNQTILSSWADHSEVNYRMYYKVVEAERSTLDNDMERTCRLFNAVIEIGLKGQWYSFLGLTYQLLAEYYVRAKINMLALPMLNQSIEFYECWGAYGKMQYMSERYGHIINSNKAMTRKVDASTQTEEQDMTNGFWQDEDSSPEPSFRELYGDESIPGLLDTETALFSLDIMDLTSIIKSSQVISNEMNSFDELLKKMMGIIMANASANVGAIIIKEGEFGIAAHSTKDEGCRTCYPPMRLDDGTDLISTLVVHYVIHTQTVLFIPNMQEDTRFATGTWLLRAEAVSVICLPIMHKNKLVGVLYLEANLSTFTRKHVTVLSLLCDQIGISVTNALLFKSVQEATTANAIMITKQQCALEEARKSKEQALKATELKSNFLANMSHELRTPFSGFYGMISLLSETRLDAEQREFVSIAKQSCEMLLQIIDDLLDFSKLEARKVKIQYGLFYIEDLIADRIELLINLASKKNLELTYFINQDVPPIVYADGHRIGQVLMNLIGNAIKFTHVGEVVVRCEIDNDTDDLKIPLKENEMMLRFSVQDTGIGMTKEETKCLFLPFSQVDGSTTRNFGGTGLGLSICLELVSLMGGNIWVESHGGSGSTFVFRVRVMKVASVAEPGIEIDPRNSEALEYTKKLGEPRILLATSKRVSDMIKTVIPFDVSTIESPEKAIEVFKSIADISQEIAGLPSPPLPTTAAYDCVILDMPPTRTVQNLLDTIESTEELKNIHIIMLYAPTVDNIKRQIGNANPNTSLRPDAVNPMFHPRVTRLSKPIRKLKLLGALLQSVNSNTPFPKNPCQEVCKNTTACINEAGKQIDHVEPSFSYAHKHREGFAPEELAVFQQQKILVAEDNPVAQKLIVKQMTRLGFSVETCNNGFECIETWKSRGPGYFSLAWIDHHMPGCDGLEATVKIRALEADMDVAITLPIIALTADIQKTAQQNCLDAGMNDYLTKPLMQKDLAAVLRRYCFHPNGGTRTTHFEEEQELTVYKPSMKLNLFIALGLLASVMLVAADDKSGYSDKDKKDNKDVKDYKDDKDYKDHKGKYYYHDKDDKDKKDDKDKKDDKDKKNGKDKRDDKDKKEDKHDKDKKDDKHDKDKKDDKHDKYKKGGKHYKKDDDKDDKHKKDDKDYKHKKYDDKDDKDDKHKKDDDKDDKDDKDKKDDKWWNYKDNILKKSDFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PRG7</accession>
    <name>A0A162PRG7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="5">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF6</name>
        <name evidence="6" type="ORF">PHYBLDRAFT_126194</name>
        <name evidence="7" type="ORF">PHYBLDRAFT_143563</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <text evidence="5">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288782.1">
        <property type="nucleotide sequence ID" value="XM_018429087.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293347.1">
        <property type="nucleotide sequence ID" value="XM_018431014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PRG7"/>
    <dbReference type="FunCoup" id="A0A162PRG7">
        <property type="interactions" value="615"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162PRG7"/>
    <dbReference type="GeneID" id="28989993"/>
    <dbReference type="GeneID" id="28991920"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_126194"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143563"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD70742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD75307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="245" mass="26539" checksum="C38ABED4F1885B0F" modified="2016-07-06" version="1">MAVRAQFENSNEIGVFSRLTNSYCITALGGSENFYSVFEGELGDVIPIVHTSIAGTRIVGRLTVGNKNGLLVPNTTTDQELQHLRNSLPDSVHVQRVEERLSALGNVIACNDYVALVHPDLDRETEEIIADILQVEVFRQTVADNVLVGSYCALSNQGGLVHPRTSIQDQDELSSLLQIPLVAGTVNRGSDVIGAGCVVNDWCAFAGMDTTSTELSVMESIFKLQDAQPSAIVNELRDTLVDTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PS60</accession>
    <name>A0A162PS60_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_169537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290446.1">
        <property type="nucleotide sequence ID" value="XM_018436096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PS60"/>
    <dbReference type="GeneID" id="28997002"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169537"/>
    <dbReference type="InParanoid" id="A0A162PS60"/>
    <dbReference type="OrthoDB" id="2431110at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="222" mass="25741" checksum="0D18CA7908C40E6F" modified="2016-07-06" version="1">MMKRFLERTYIDSFIQSFVNHLPQFAIDFLYCISNSQDQLAALHLSSTASTFSLSDFVEYLLNPCHSALGCEPLPPSVFPIKLDQRITMCKGHYECLLEFYRHANTLLDLISTPIILRITEDKAVFPGHILYLFQHLITINETVITHTFAFVEWYSSYSLGSYQPMLNEDIELWNEPSSVLNYECIIPVYHLYSPITIAKYRFTITSEFKHLVIPLPQKIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PYX4</accession>
    <name>A0A162PYX4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_60407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295317.1">
        <property type="nucleotide sequence ID" value="XM_018440637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PYX4"/>
    <dbReference type="GeneID" id="29001543"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_60407"/>
    <dbReference type="InParanoid" id="A0A162PYX4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="127" mass="15146" checksum="B0299F8941BD425D" modified="2016-07-06" version="1">MGVLSQVDRSNSCVNLGQWYQFVVEDTKRQKYKFRTKFIDFYSIYRIIFAHSDFFFEPTLPVFFFHDKFPDFMRFLQGINCLLLCTIFWHEKDKNSIVLHIKICPHRVCAGPAEFFQVQESVIACIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q264</accession>
    <name>A0A162Q264_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_130062</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297687.1">
        <property type="nucleotide sequence ID" value="XM_018429334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q264"/>
    <dbReference type="FunCoup" id="A0A162Q264">
        <property type="interactions" value="330"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162Q264"/>
    <dbReference type="GeneID" id="28990240"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_130062"/>
    <dbReference type="InParanoid" id="A0A162Q264"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000002">
        <property type="entry name" value="Dnaj homolog subfamily b member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD79647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="315" mass="34129" checksum="E6BE067500CE17D8" modified="2016-07-06" version="1">MGKDYYSILGVPKTATEDEIKKAYRKQALKWHPDRNKDKIDVAKAKFQEIGEAFEVLSDKDKRTIYDQYGEEGLKAGPPPPGGAGGAGGFPGGAGFGFPGGMGDDDYDSFGGAPGGFSFGSGGGGQRFKQRQSSAKPPAIKRILPISLEDLYKGTTKRLKVTRKLRDGASGKYVTAEKILTVNVKPGWKAGTKIRFPNEGDELPNGQQQDIEFVVEEKPHPIYTREGDSLRMTIQLTLAEALAGFSKHIKTLDGRTLGVNNSNSVVHPGQESRVRGEGMPNSKTGAKGDLIIKYDVKFPARLTDEQKEGIKKLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T335</accession>
    <name>A0A162T335_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_73176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441007">
        <property type="protein sequence ID" value="OAD65892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283932.1">
        <property type="nucleotide sequence ID" value="XM_018442798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T335"/>
    <dbReference type="GeneID" id="29003704"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73176"/>
    <dbReference type="InParanoid" id="A0A162T335"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="289" mass="33648" checksum="DEEDCE14F816C225" modified="2016-07-06" version="1">MHKDMFCARGLKEILQRASYFFARYSWSERNQKNTHRVNHIVADTTQGIIIFVIYDSSMNNYEFICYRLHDPFDYLTIDRSCILDEAAPNIVLLAYICRSYITHCQEDGITYSNTYLSSPNFVLEIIDANKRGISSVTTDREPLPISEGSLEPSSWLSYQPSFRLPFIFASATMLASTSETENRRMTQCEFQSAFLRNSERQTAIFDEVITSISLQLEKIKDVFVYSVECQYIHAVSFWGGMLLGQDIKRQQCMGRRPRKKVDFQSQFSQQRNNCKRRKRSKMQIIGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T972</accession>
    <name>A0A162T972_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_70335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD66982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285022.1">
        <property type="nucleotide sequence ID" value="XM_018442260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T972"/>
    <dbReference type="STRING" id="763407.A0A162T972"/>
    <dbReference type="GeneID" id="29003166"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70335"/>
    <dbReference type="InParanoid" id="A0A162T972"/>
    <dbReference type="OrthoDB" id="2430203at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD66982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="171" mass="20129" checksum="235746D93B387082" modified="2016-07-06" version="1">MVAMCSILGRTETFHINNLIESYHNQQKTFYLECARSLQVDRLIYLLAKVLTLDYRQENVKTLYRFQSVCLTRQEEQKRQNMYMLDSDTTMDMVEKLSDTAFTCRSFTVDLVVYNIELQNDFLQSCTCSDTSKLCKHIFLVNYMLDIFYSLCHSLFFSSSAVHEKPLKSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TCM1</accession>
    <name>A0A162TCM1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">p53-like transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_183552</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285582.1">
        <property type="nucleotide sequence ID" value="XM_018438791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TCM1"/>
    <dbReference type="STRING" id="763407.A0A162TCM1"/>
    <dbReference type="GeneID" id="28999697"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_183552"/>
    <dbReference type="InParanoid" id="A0A162TCM1"/>
    <dbReference type="OrthoDB" id="2288358at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052605">
        <property type="entry name" value="Fungal_trans_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF2">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NDT80" evidence="4">
        <location>
            <begin position="111"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="2">
        <location>
            <begin position="111"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="347"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="437"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="593"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="360"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="444"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="521"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="559"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="616"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD67542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="655" mass="72820" checksum="5EAB362A60CD3BC6" modified="2016-07-06" version="1">MNPSHEAKEWQISQSPLQQGPPQSDGPAIVSGAPHSMQQYSPLPTMGHPYSHSFAQASPMHPPIHQYLPITSGYVPPNRVESDPRLPGMMALSQPGTPRPNSVSHDVLPSPTKMSRQSYATSSFHAGPYPPIALARKRSRNDSLCPAEAGPVFSSTKPFDNLYALDRTTLMVPRIQAKMDRGFFLFYNDWTCYRRNYFQVSGAFSIQGLNHYYADTEPQCLVQKEDGTFSQIERFYLGISARVSNSEKEIELIQHTPKRDKGPQIKPEAKAITAGGNLGMSTVGANQNIATFERIQFKTATANNGKRRAAQQYYVCLVDMYALTADDGQKIKIASCQSAPLVVRGRSPGHYADSQERHNSIQSTASATAGTGPVSNDGPQLSPQSQSDEQQQRFTTPFPRPPMTPPGMMPAEYNSSAGGYPYYSNYPHFAPPLPHNGVMMNNGPHTPSHHPSTPSPYPHQQQQQQHPHSQHQNQQQPHPHPSQASHPYMVHSMPETPQDSSSPDMYPGEYVNQHQHHQQHHQQQQQQQQQQQQQQQQQHHHHQGNNPNSNNNDHDNSKMSHLSQAQAQAHHNSNLNIQIPMDSTTAEWTRNRFHSSGSVQSPAHDHPQNSYFPHGTPTLSSAASQTSAFSPTTPTTPYGPRKYNAVPNLVNQQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TCR0</accession>
    <name>A0A162TCR0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleoside diphosphate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_119584</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV441006">
        <property type="protein sequence ID" value="OAD66083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284123.1">
        <property type="nucleotide sequence ID" value="XM_018428692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TCR0"/>
    <dbReference type="STRING" id="763407.A0A162TCR0"/>
    <dbReference type="GeneID" id="28989598"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_119584"/>
    <dbReference type="InParanoid" id="A0A162TCR0"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46161">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46161:SF3">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE DDB_G0292928-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="9">
        <location>
            <begin position="2"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD66083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="110" mass="12570" checksum="06B0901F15654189" modified="2016-07-06" version="1" fragment="single">AVQQTLALIKPDVTVTACKQEAMISMIIDAGFKIVKEREIHLSVDQARLFYREHESKPFYNDLVNLMSSGPVYAMVLEKENAVQAWRELMGPTDSKKASEIDPNWQVLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TGL5</accession>
    <name>A0A162TGL5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_151921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD66983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285023.1">
        <property type="nucleotide sequence ID" value="XM_018432786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TGL5"/>
    <dbReference type="STRING" id="763407.A0A162TGL5"/>
    <dbReference type="GeneID" id="28993692"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151921"/>
    <dbReference type="InParanoid" id="A0A162TGL5"/>
    <dbReference type="OrthoDB" id="2506357at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="63765" checksum="6360FDE46874CFFE" modified="2016-07-06" version="1">MSNSNYTQLSINDINDDHMIQIAPDYEMANPKVTETFADEGKFTVWFENLAKRHSNWNVTNTHFSQATSTASLRDVVLTVYFVCDHQEFLKKAKNGCKAKITKKTLRDESVQVDYLWQHATHQPENKAIKTLLRINPQRLDELKAGIDIASFPMSLRINYHDTSVEQWIEFLEKEKNYLVHIVFHEGNGPYLVSWISPWQKKILELADEWCIDSTHKTCKSLVDSSKHSYLYTIVVRSNVTNKGVPVCFFVTNAEFITTLLQWLNWVKSNCSLCVKCMMIDCSPVEIGALEEDFGQSVQVLLCHWHIKRAWEMHIKKDVKITGATHKSKCEQNAVWVALNLLIHARSKEHAKCALWSMAWRVDARFYTDNLIESYYHILKAYYLGRSRNFWTDWLVYMLSQVVEHDYRQEGLKIMYRFKQLVLTYTEKSKKKKAYDIAHEDALGMIYKCCSFTDNSVWYKLLVKEEVLSVCSCPDPNHLFQIVDQSEKSSLAQNRLRALEFVERHSSLINKIAQAVGKINAVARDTASGMDITSQILEDCLSSLKESGVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TGS4</accession>
    <name>A0A162TGS4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_117632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286502.1">
        <property type="nucleotide sequence ID" value="XM_018428587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TGS4"/>
    <dbReference type="GeneID" id="28989493"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_117632"/>
    <dbReference type="InParanoid" id="A0A162TGS4"/>
    <dbReference type="OrthoDB" id="8663161at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="9356" checksum="71467FC9EBA5B651" modified="2016-07-06" version="1" fragment="single">EDNAKVHKLKVTGKFKKEHGIDILQWLLNSSDLSPIENIWRIIHCKRPLILVPENLQKFYYNFRFLIFSNNFYFFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TJN9</accession>
    <name>A0A162TJN9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor E2F/dimerization partner</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_172375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287162.1">
        <property type="nucleotide sequence ID" value="XM_018436786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TJN9"/>
    <dbReference type="STRING" id="763407.A0A162TJN9"/>
    <dbReference type="GeneID" id="28997692"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172375"/>
    <dbReference type="InParanoid" id="A0A162TJN9"/>
    <dbReference type="OrthoDB" id="552115at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000360">
        <property type="entry name" value="Transcription factor Dp-1, a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015648">
        <property type="entry name" value="Transcrpt_fac_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="3">
        <location>
            <begin position="319"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="88"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD69122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="464" mass="51743" checksum="F60CE87B6CA0BD93" modified="2016-07-06" version="1">MEPTYPSLHPLPNRLSPPTLPYTRHQSDNLNQHYNHHTNYKDYHHYNHTQHWRSHDLLQLQSLLCNKPQQDTNNHLPPLILLSSISSSTTTSTNNNSPYGGQSPSLSTSFSSSSSSSSSSSSSSPPLSSSSPSPSPAAESISTFPSPQQDQDFDLDHNKQHHWSPSPPSSSASDNVVVVDDSVRGIVSVTSLLNPVPELPEPKRKKNRSGYLSDARNQMPATKIAPNRSSSNILLKRGRPRQLTLNNTNMNMNMNSNNINSSIFGTSGTPPVAADHLHFTQNTKKQRRYKSKKNKTENNHNDDDDDNHIALDVSEDHRRLNKGLRHFSKQVCDKVAKRGTTTYNEIADELATDIRNSPQDNQPGCDQKNIRRRVYDALNVLTAINIIEKDKKEIKWLGIPGCTNTHSETAKREADLLREIEEEERCHIELTASVEAAREKLAQASLSQMFALPNCPTAFPCPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TSY3</accession>
    <name>A0A162TSY3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_126915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287583.1">
        <property type="nucleotide sequence ID" value="XM_018429133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TSY3"/>
    <dbReference type="FunCoup" id="A0A162TSY3">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TSY3"/>
    <dbReference type="GeneID" id="28990039"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_126915"/>
    <dbReference type="InParanoid" id="A0A162TSY3"/>
    <dbReference type="OrthoDB" id="6251714at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD69543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="27662" checksum="A6161601260A4517" modified="2016-07-06" version="1">MGRLEGKNILITGASAGIGEACAREFAKEGSNLILAARRLSKLDELKADILKQHPNITIYTVALDVSDKENIDKVVPGLLEKVKHVDVLVNNAGLVIGLDRLLDTSAEAIDAMFNTNVKGLVFLTQAVLPGMLARQTGHIINLGSVAGKQSYGGGSIYCATKHAVDAITRALSIELVDTPLRVSQICPGMVKTEFSTIRFRGDQEKADNVYKGLQPLVGQDIAELIVFTASRPPHVNISDMLVFPTAQADSKTISRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U0N9</accession>
    <name>A0A162U0N9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable electron transfer flavoprotein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_134895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289423.1">
        <property type="nucleotide sequence ID" value="XM_018429681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U0N9"/>
    <dbReference type="FunCoup" id="A0A162U0N9">
        <property type="interactions" value="175"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162U0N9"/>
    <dbReference type="GeneID" id="28990587"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_134895"/>
    <dbReference type="InParanoid" id="A0A162U0N9"/>
    <dbReference type="OrthoDB" id="276685at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000011">
        <property type="entry name" value="Electron transfer flavoprotein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000049">
        <property type="entry name" value="ET-Flavoprotein_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF8">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01065">
        <property type="entry name" value="ETF_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="7">
        <location>
            <begin position="26"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00070315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD71383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="256" mass="28276" checksum="35CF07AA64783719" modified="2016-07-06" version="1" fragment="single">MSNPLRIYVPVKRVIDYAVKVRVNPAKTDVDRSVKHSMNPFDEIAIEEAVRMKEKDKKIEVVAISCGTTKSQETLRTALAMGADRAVHVEVKDDSTLQPLAVAKLLQAYTATQENKPDLFILGKQAIDDDASQTGQMLAGLLNWPQTTFASKVELEGQTLKVTREIDGGLETVQAKLPAVITTDLRLNEPRYASLPNIMKAKKKPLVKLTPEDLGIDISPRILTLKVEEPAKRVGGRKVDSVDDLIDKLKNEAKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U576</accession>
    <name>A0A162U576_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_63779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291572.1">
        <property type="nucleotide sequence ID" value="XM_018441180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U576"/>
    <dbReference type="GeneID" id="29002086"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63779"/>
    <dbReference type="InParanoid" id="A0A162U576"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="108" mass="12447" checksum="A7CD56C929D8081B" modified="2016-07-06" version="1">MIISIYREFIYISYSTLDMRNCENSNIAGHIMREHEPILAFGSHLHNTGLNVWYMLVPEISQSDFLISRLKKVADMSLCSAIRGTATFKESVIIRGFQQSFKLLNLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UCH6</accession>
    <name>A0A162UCH6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_144551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292133.1">
        <property type="nucleotide sequence ID" value="XM_018431239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UCH6"/>
    <dbReference type="GeneID" id="28992145"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144551"/>
    <dbReference type="InParanoid" id="A0A162UCH6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD74093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="145" mass="16528" checksum="5023D805B13A9BD1" modified="2016-07-06" version="1">MVEKLSDTVFTCRSFTVDLVVYNIKLQNSFLQNCTCLDTSKLCKHIFLVNHMLDIPYSLRESLSSSFSAVHVSNTDTKAVVNTSLLSDKIEADIMKYHQLYSVELDSKIAKYNGISEDMSQFLDTLKFSYNKLKEHGFPSQSRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UGI8</accession>
    <name>A0A162UGI8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHYBLDRAFT_144376</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293063.1">
        <property type="nucleotide sequence ID" value="XM_018431203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UGI8"/>
    <dbReference type="FunCoup" id="A0A162UGI8">
        <property type="interactions" value="322"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UGI8"/>
    <dbReference type="GeneID" id="28992109"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144376"/>
    <dbReference type="InParanoid" id="A0A162UGI8"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23284">
        <property type="entry name" value="beta-trefoil_MIR_PMT2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000012">
        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="237"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="652"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="708"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="344"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="412"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="476"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAD75023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="754" mass="86207" checksum="E3EE82CEBCAF3B6D" modified="2016-07-06" version="1">MENLKRRHPPQQKISSYSPPPPYSDIYESVSLNGDNCSGTYSTKEKSHRIYKDSQFSSRALYFLREYKHTIIAITLTAISLWTRFRKIDVSDIVVWDEAHFGKFGSFYLKNEFYFDVHPPLGKMLVGLSGYLAGYNGSFGFDSGKHYPPEVNFKFMRLFNATWGALLVPLAYLTATQFKMSQKASLLAATMVLADTAYLCISRFILLDSMLLFFTCLSLFTLSVFHNLQDQSFSKSWWLWLVLTGLSLGCVLSVKWVGLFAVALVGLYTAEDLWEKLGDVQMPKKKYMGHWIARIICLIVIPAIVYLASFKVHFAILRKSGPGDGQMSSLFQAQLEGNSLSKNPLEVAFGSNVTIKNVAYGGGLLHSHPHLYPSGSTQQQITCYHHKDPNNEWGIAEPRYEENQDVPEVDGIRYLKDGDVVRLVHLATGRNLHTHPIAAPITSSHWEVSGYGNASMGDIQDNWKIEIVKDLTHNDKNHLRSLSTRFRLRNVQLGCLLGSHNTILPQWGYKQYEVYCDKRNQTDNDKTLWNIEEHKNEKLPKPPKNTYKSKFLDDFIQLNVAMWTSNNALIPDPDKEDILASTPLQWPFVSIGLRMCGWGDKQFKFYLLGNPIVWWLSSGSLVAFSLLYSFYSIRAQRQINDMKPEKSENFFYVGKTLFLGWFLHYAPFFIMGRVTYLHHYFPSLYFSIFMAPFLLDHLTAKASARTQNLVFGAVFTAVIGTFIYFAPFAYGMMGPISSYAGRRWLTKWNLLDTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UJW1</accession>
    <name>A0A162UJW1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_165793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293853.1">
        <property type="nucleotide sequence ID" value="XM_018435308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UJW1"/>
    <dbReference type="GeneID" id="28996214"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165793"/>
    <dbReference type="InParanoid" id="A0A162UJW1"/>
    <dbReference type="OrthoDB" id="2444812at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="83"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD75813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="288" mass="33097" checksum="58CA2AF8ED3F89C0" modified="2016-07-06" version="1">MSASDSEQVTSQAETHVDEVPNDNGSEDSVVEKTNKTTETDANTSLDDSKTDEPAKHEIKQEKKETKGKGTDKAEKKIHPSKADIAKAWTAAWDQNSQSYYWWNTLTYETTWENPLGDGSKADSEQTEDYSLYYYGYPAVESSQTATRPDHVSDNPLDSLLDKIDTQVRSTFDDTVEQSPAEKTQTPYSSYFGTEDQYKFQAVFNAKTGKFQTSEEVERLHPDRMTIESRAKRQMQYYFDVDAYMDERNRERAAGAGQKRPLTKKDLDRFKKAKMEKKMKRARDWLCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UKP4</accession>
    <name>A0A162UKP4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_142989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294043.1">
        <property type="nucleotide sequence ID" value="XM_018430915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UKP4"/>
    <dbReference type="STRING" id="763407.A0A162UKP4"/>
    <dbReference type="GeneID" id="28991821"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_142989"/>
    <dbReference type="InParanoid" id="A0A162UKP4"/>
    <dbReference type="OrthoDB" id="2442555at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="28258" checksum="D507F2F1C5206633" modified="2016-07-06" version="1">MPTSNNSLEFVMDKHCEMVSHSGSADQTQFSGIAFDPLCDFNQKIVDEMHGEVVLRSVTYIFVNHADMEWTRTSAGNPAVTNLLSLRSFLPTEVNKATTKTIVAQKPKMNLLEKYNQNQVNKLFSLVFSENQTAAAAARETGINVRTAQNYVRLAREKIQADFDAATVETDESNGLETMAIEEFFENKPDATLEQARIAVMEEFSGLQITKSAIQKHLVKKCALTMKKLEKLPEKRDNVSTIEMRRDCILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UKS3</accession>
    <name>A0A162UKS3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_165334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294872.1">
        <property type="nucleotide sequence ID" value="XM_018435203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UKS3"/>
    <dbReference type="GeneID" id="28996109"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165334"/>
    <dbReference type="InParanoid" id="A0A162UKS3"/>
    <dbReference type="OrthoDB" id="2267841at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="304" mass="34785" checksum="41BFDDA174992880" modified="2016-07-06" version="1">MTFIGIDGAILITFINTILEHYGDEFRLTNIPGLKKMTGYSDFTNCVSNYVACSDCYTLYNYSNNTYTSWNSKKVSSKTFCGNDLYNSGIRNAVIQKRTFRLFSFDRFNGVLKGFQTNQKSGFEKTYMKKFIEVSSKGDFYHTHLNTITSPSYIPLFSKLTDSITRTIPSGNHQNSPPFFHLPSFLESATNPEQQTFGNEPLPPSALPLVLKEATTMRKSEYGCLLKFYKIEYDDESLCSAKTMIRHRIFVNDRVQKISFINLLGQVYKGDEGLVMRKSYIQARNLTTKIRSSLYNPLLNCYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V2K4</accession>
    <name>A0A162V2K4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metallo-dependent phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_129957</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297573.1">
        <property type="nucleotide sequence ID" value="XM_018429320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V2K4"/>
    <dbReference type="STRING" id="763407.A0A162V2K4"/>
    <dbReference type="GeneID" id="28990226"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_129957"/>
    <dbReference type="InParanoid" id="A0A162V2K4"/>
    <dbReference type="OrthoDB" id="10252235at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF48">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="6"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="6">
        <location>
            <begin position="322"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="581"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="632"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="601"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="638"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD79533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="667" mass="75342" checksum="1AD423B677295C0B" modified="2016-07-06" version="1">MTTLELVHFNDVYHVSPNKDEPVGGASRFSTAIKSCIKEDEDLNPLVMFSGDVFNPSLEGSITRGSHMSDVMSNLPITVACLGNHDFDFGLPQLQRNLAATNFPWLMSNVLFEDTNEPPVQSLRYLVIDHPESGLKLGVLGLVEKEWIETIPSFPPELVYHDFVQTAKDLSAELRDPEGPHKVDFIVALTHMRVPNDIKLGRECSDDVDIILGGHDHFYYVSNHVDIVGEKWTREHNLDDVGFDPEEEPFDKPVWVIKSGTDFREFSVLKLEIDTDEDGRKKIKSMTAERRTVDSSVEPDEEMDVIVEKVAELVSEKTKRAIGYTTVPLDGRSFAVRTEETNLGNLTADLMLLSYRYLGADFALCVGGTIRNDSIIDVGPITIGDIMNIFPFTDPCVLIKVTGRQLWDALENSVSEYPKQEGRFPQLAGLRLEWDPTKPPGQRVKNARYMPENMAPLDLDEEYSLVTRHYLTGGYDGFTSLNVPASKIVVDEENGLLISTLYRKFFLGLKYLNAVRENLVKPVAAKIAREKKKRIDQLVASAASHWRKVTQDIQASRDHEPEDIEGRAEFHVTEEGVLQAFEDSSQGHPNCISPEEDEDKVSEPEEMYKHEEEDTSWVKRWASIGPVIQGRIYRVPADEEDEEVKEPETEEAETEAAETEVEEKEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V4V6</accession>
    <name>A0A162V4V6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF2828 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_105673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298013.1">
        <property type="nucleotide sequence ID" value="XM_018427912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V4V6"/>
    <dbReference type="GeneID" id="28988818"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_105673"/>
    <dbReference type="InParanoid" id="A0A162V4V6"/>
    <dbReference type="OrthoDB" id="1149618at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058580">
        <property type="entry name" value="DUF2828"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056690">
        <property type="entry name" value="DUF7788"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011205">
        <property type="entry name" value="UCP015417_vWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31373">
        <property type="entry name" value="OS06G0652100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31373:SF27">
        <property type="entry name" value="TROVE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11443">
        <property type="entry name" value="DUF2828"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25043">
        <property type="entry name" value="DUF7788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015417">
        <property type="entry name" value="T31B5_30_vWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2828" evidence="1">
        <location>
            <begin position="13"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7788" evidence="2">
        <location>
            <begin position="451"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD79973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="700" mass="79296" checksum="1F226684FC9BCB4A" modified="2016-07-06" version="1">MDSLLATTNLTRTTNGALAHVSTLDSCLDLHYQLGGEDWNLETMFNLLEQAWSQDPLCTLRIIFSARSIHRGNAAKEKFYLAFGWLITHHPQTALANLPVLTNGTVFVPHVSKKDSSAKKDGWDIVEERPEEKKKHLKGQSKSHGYWKDLSNLLSIYATGEINGPVLSGKYKALYQRAKEVEEAQKASTEKARQERRQARKFRQERVISFLENDPKYRALHFSVARQFAEQLKKDYETLQDLKDEPKRYKYAISDKLSLAAKWAPTLQRSHDRNTLLATSISELLFPPETYQKEGESREYYLNKVRELYRKQYLGPLREALQVTERKMQAGQWDAIDFSHVPSVCMQNNSGRFFKHTPEKFTEYIEQVALGNKSISGATLSPHELAKRAYYTCNKSDPFEEKLPSFLKGIADPEVLEKAKAVERSMLNSQWNTLVQSIRNVAGDGNANLGSSIAICDLSGSMYGKFSNGVVPIWCSIGLSLILATLAAPPFDGAIITFSEEPTVVKIDHSKTFVDQISDLMAAPMGYSTNFEAIFVDLLLPMAKKNKISQKDMVKRLFVFSDMQFDETEDRTKYNTMYQTIEEKYKEAGYDVPELVWWNLGGTKEDPIKQMWYHNSVLGWSDDDNDEEVATPLPVTADVKGCTMVCGFSASILKNFIEGEEDVDGEEALEGKEKKEPTTPVENMLKHVSHKSFSSLVVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V6Y4</accession>
    <name>A0A162V6Y4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_17816</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298482.1">
        <property type="nucleotide sequence ID" value="XM_018437960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V6Y4"/>
    <dbReference type="STRING" id="763407.A0A162V6Y4"/>
    <dbReference type="GeneID" id="28998866"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_17816"/>
    <dbReference type="InParanoid" id="A0A162V6Y4"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="39"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD80442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="200" mass="21627" checksum="04D1D53CE6A76ABE" modified="2016-07-06" version="1">MAASFAVSAQALKTPPTTLQIGIKKKIPEEQCTIRSRDGDSLSMHYTGTLFETGDKFDSSVDRNQPLEFTLGTGRVIKGWDLGLKNMCIGEKRRLVIPPHLGYGANGMGSAIPGGSTLVFDVELVDIHRSNPDSPTTGQEKQEFVKPLNAPGLDFTSPIFLFSAVGVSALLVIVYLATKSGEKVKEEPKVDQTTEDSKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V729</accession>
    <name>A0A162V729_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_129190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298543.1">
        <property type="nucleotide sequence ID" value="XM_018429268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V729"/>
    <dbReference type="STRING" id="763407.A0A162V729"/>
    <dbReference type="GeneID" id="28990174"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_129190"/>
    <dbReference type="InParanoid" id="A0A162V729"/>
    <dbReference type="OrthoDB" id="70823at2759"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000044">
        <property type="entry name" value="Deoxyribose-phosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="8">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001357-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD80503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="235" mass="25051" checksum="080A846D3DBE2141" modified="2016-07-06" version="1">MSNITLETVTYEQVAKMFDHAILKPEQTTLDVIEGCKLAVEYDVKSVCVKSCDVKQAASLLNGTSVLVGTVISFPHGNAPTSAKVAEAIQAVRDGAIELDVVINIGHLKSGLIEECEKEIAAVIDASKKENANVVFKIIFENAYLTKEEIVAACKLSVAAGADFVKTSTGFASSGATYDDIELMRASVPDNIEVKASGGIKNLDQVITFMQKGATRCGSSSSGQILDEFKKRRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162VAC2</accession>
    <name>A0A162VAC2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_138729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299232.1">
        <property type="nucleotide sequence ID" value="XM_018430057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162VAC2"/>
    <dbReference type="GeneID" id="28990963"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138729"/>
    <dbReference type="InParanoid" id="A0A162VAC2"/>
    <dbReference type="OrthoDB" id="10053513at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="139" mass="16048" checksum="EA781E5DD39462CF" modified="2016-07-06" version="1">MDETYYAHLLQHYKTSYDLPNLVSYQYATLTSSFVDNEITKLKFIDLLGQQYRGKNGSASCGSLVHVMFVGSDGRNTLAYAGQIQYLFTHSFTHPSNSNLHMTRMVHDYQHVFAYIKWFNTSSDRSREDDGLEFCLCCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162VBH8</accession>
    <name>A0A162VBH8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_71352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299472.1">
        <property type="nucleotide sequence ID" value="XM_018442452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162VBH8"/>
    <dbReference type="STRING" id="763407.A0A162VBH8"/>
    <dbReference type="GeneID" id="29003358"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71352"/>
    <dbReference type="InParanoid" id="A0A162VBH8"/>
    <dbReference type="OrthoDB" id="2283219at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="191" mass="20670" checksum="229D594850ABE1D4" modified="2016-07-06" version="1">MQDANSSENTHGSYEKADPYKYGCIMYMHLANYGATQISLVVGMSLSTVKYIIKRVDETGSPEPRKGSGRPRKIDERTERHLVQIVLEGNDGGARAIRKVGERFKEENIIEGTKWGKGSVMIWSCFWAGGFGPLVFLDGASCSKRTTPAVILGRTRGGGKIAMRSEVLTTGPLKARISTPSSISGGLSRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WCC1</accession>
    <name>A0A162WCC1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_160625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441004">
        <property type="protein sequence ID" value="OAD66235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284275.1">
        <property type="nucleotide sequence ID" value="XM_018434218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WCC1"/>
    <dbReference type="GeneID" id="28995124"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160625"/>
    <dbReference type="InParanoid" id="A0A162WCC1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="64" mass="7357" checksum="321DBC130FBFCB76" modified="2016-07-06" version="1" fragment="single">MAIQILCQGLPEYFSFCGVESISLGENVLVNICIQKMKNISLLGQEFFSEQKKYRSSIVRVMFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WEL0</accession>
    <name>A0A162WEL0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_152398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441002">
        <property type="protein sequence ID" value="OAD66595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284635.1">
        <property type="nucleotide sequence ID" value="XM_018432902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WEL0"/>
    <dbReference type="GeneID" id="28993808"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152398"/>
    <dbReference type="InParanoid" id="A0A162WEL0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007840592" evidence="1">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="91" mass="10437" checksum="7487573689073834" modified="2016-07-06" version="1">MGHEVGFLSEILFLYLLQKDVMSHSESDMKDMNVETLNHFVEIVDFVAVQTCSDKSMLKSRARMPRLQLGEKNDVVSRHLISSLSPWAIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162X8V0</accession>
    <name>A0A162X8V0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_65877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291315.1">
        <property type="nucleotide sequence ID" value="XM_018441548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162X8V0"/>
    <dbReference type="GeneID" id="29002454"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65877"/>
    <dbReference type="InParanoid" id="A0A162X8V0"/>
    <dbReference type="OrthoDB" id="2253782at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31639">
        <property type="entry name" value="F-BOX PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31639:SF256">
        <property type="entry name" value="OS07G0242900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="658" mass="76274" checksum="4E0BC388DAC84E1B" modified="2016-07-06" version="1">MGVSDLPFEILTQVAYNLPARDKRSCACTCKRWKYPFQMALWRNIKARDYSDIQKIINSIKASQSIYPLHSLWVHSLHMHHSYGESNLQDINLSDLFRNLPNLKRLELEVGNCKDIYTEIPRSDEIWKSLESLKIKYSAIISREPPQNVLEFINACTMLQKLEIHKHGEGYRMEFNVDDFNSMHQNLRILSSIKAKLCLRANFPATLDTIPNTTPAFGMISLDIDSRISEKTFGYIDSFRSNWNPLWLYYFGYKYPNLRSLKLNATDAWEKSMDLDKRQRIISLFQSNTNAFKHLETLVFTTNEHFQFSDFILWELLWALKVPLKHLTVDTTYNGEIDGPYPMTIGRILQFVSETLKSLSIIGPIYSDNDKKPTLELSHYFPFLTNLCISGSNVSLNLDDVLGRCVTLKQLKICGGRLFINPSMTTEESKQQQQQQQHHHPQQQYGLQTLKLYDCTISAKVFNHLSFRCRSLKHMNLNTLCILGSVCEKTGCLLLDMSHTFLKTLYIGQIRYSRSYEEMKANDYINMTLLSQLNDAPLSDEESERKKNEMDLEYSTVDFGSMNWLHTYEFDSDTGAKDYVTVRLSAEEVDSVLEYFKNFQSSRISSTFDDSSSCDGQETQIYWNHDLHKGYGELRLGNIEAVQVICAQKDNSFRKYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XCW0</accession>
    <name>A0A162XCW0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_168445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD74035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292075.1">
        <property type="nucleotide sequence ID" value="XM_018435867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XCW0"/>
    <dbReference type="GeneID" id="28996773"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168445"/>
    <dbReference type="InParanoid" id="A0A162XCW0"/>
    <dbReference type="OrthoDB" id="3247418at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="281" mass="31543" checksum="4F5EBAA61CEF11B1" modified="2016-07-06" version="1">MMGYTLVPKIISHRYSKKAALKDAVRSEMGMAFKTHLMNVYADFKSYLFEYKKTTLLLYSIFVAIVIHEYGSAEVHARQSDLPILDISPMSFDNVSVDSEVDENFNEIDVEHESNETTEDIDDIKVEERYNGLLKNISTNGKDGFEAAFMRCFVEDIYKSDFVNSALTCPTQAPFLPVFSKLVCLSTPVLTLSSASSTIVQPPLILIIIIGNEPLPSTSFPLSVSKPSSMGDIDYPYLLQYYKLAYLTPDLVHYQSSAASLFFANDQIIKLKSINNIGQVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XLZ4</accession>
    <name>A0A162XLZ4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_123991</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293675.1">
        <property type="nucleotide sequence ID" value="XM_018428964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XLZ4"/>
    <dbReference type="FunCoup" id="A0A162XLZ4">
        <property type="interactions" value="581"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162XLZ4"/>
    <dbReference type="GeneID" id="28989870"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_123991"/>
    <dbReference type="InParanoid" id="A0A162XLZ4"/>
    <dbReference type="OrthoDB" id="10263513at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD75635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="119" mass="13088" checksum="6D639C142EB84288" modified="2016-07-06" version="1">MAKKDVAAKPSSSSGGKKAKKKWSAKKVKDKSNNLVVLDKPTHERLFKEVPTYKLISQSVLVDRLRLNGSLARIAIRELEAQGLIKPLSRHHAQVIYTRATGDEKAAPVAADKAESDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y8Y1</accession>
    <name>A0A162Y8Y1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_141120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD79065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297105.1">
        <property type="nucleotide sequence ID" value="XM_018430531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y8Y1"/>
    <dbReference type="GeneID" id="28991437"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141120"/>
    <dbReference type="InParanoid" id="A0A162Y8Y1"/>
    <dbReference type="OrthoDB" id="2442555at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="265" mass="30391" checksum="43532B23FEC6EE73" modified="2016-07-06" version="1">MNMIFDATTMDIVDDYEERTIDTMTNAVLHEWKVTYPNSGNGIQTLPRGTYHKYMPEQVQGLFELVIENGWTAKMAAKKMGINVRTGQNYIAQYRKDEEQRLPGSTGKRSVSTPPKLLQQHSSFLIVYFENNVAVTLQEARTALLEKFKDLTITLSGLQKHLVNKCCLTLYKLEKLPAARNSEWVIQLRKDKVTEWFSILDFDYVRDCVFINEEGFNMHINITILEAISQIGVISVTLRKPQAVVSSKKCKLDKKVEKINGHVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y9P8</accession>
    <name>A0A162Y9P8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate transporter-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_97869</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CitM (TC 2.A.11) transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297245.1">
        <property type="nucleotide sequence ID" value="XM_018444034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y9P8"/>
    <dbReference type="STRING" id="763407.A0A162Y9P8"/>
    <dbReference type="GeneID" id="29004939"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_97869"/>
    <dbReference type="InParanoid" id="A0A162Y9P8"/>
    <dbReference type="OrthoDB" id="442352at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43302">
        <property type="entry name" value="TRANSPORTER ARSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43302:SF5">
        <property type="entry name" value="TRANSPORTER ARSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02040">
        <property type="entry name" value="ArsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="512"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="9">
        <location>
            <begin position="64"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD79205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="530" mass="58018" checksum="08E069F46AD8C06F" modified="2016-07-06" version="1" fragment="single">LDAYSWVTLVIFLLSIVPVIRPFKIPFFRQTHIRLNLATSPPLGVLILLIIRAIPITTVRDGCIGSMGIQPYAILILFYSLAYICISLDLTGLFQYLAFWVSRKAGNRGILAFTLFFCLTSLMSGLTSNDVVILTGTVFLSYFTRVSGINPTAFLVSEFTTANIASMALYIGNPTNVIVSEAYDISFIEYSAWMLLPTVVTLLLAYCVLRVMFNNPVYLPRQIVAPDASPNSVLLDPKGAVFGTVLLACCLATLVGTSFAGVSVWMVTLPFAVVTLVRDFLYDLGSIKWMHSNNGLSTVTGSIDIDIDISTSSTVNNGTIDSIDRTRRSSRGSLSNRSIGLQSLPATRAETAPRETVGLHRSFQRRLGQRIKRLGYRWPTVFAVIQRMPWAILPFSLGMFVLVEGLSLVGWVGVLAKGLVVFTLNYVTAVYGVTFVSIVACQLLNNLPMTILLTRIIQHPNFSSRVTSPVIMQGVLLGLIVGSNLGACLTLVGSLAGIMFDHILKSKNIHVLGYRNFLGWNLILLPVLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YD49</accession>
    <name>A0A162YD49_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_130323</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14 15">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297995.1">
        <property type="nucleotide sequence ID" value="XM_018429350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YD49"/>
    <dbReference type="FunCoup" id="A0A162YD49">
        <property type="interactions" value="1382"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162YD49"/>
    <dbReference type="GeneID" id="28990256"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_130323"/>
    <dbReference type="InParanoid" id="A0A162YD49"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000005">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12436">
        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="10">
        <location>
            <begin position="55"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="209"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD79955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1115" mass="128494" checksum="5DA6E4F983087FA6" modified="2016-07-06" version="1">MDNQQNPMNELLPPYDMDRPMPDADQAPSEISVLDHYEIIARNEMNPVEEEIIELQCQHWDINNWSSLEDRVHGPTFEAGGHQWNVLLFPKGNNQNEFASLYVEMTDAKTVPDNYCCAQFVVCLTKPSDPFQYIHHAAQHRFNSEESDWGFTRFIELKQLYSLDEQGNPRFLEDDNVRITTILRVIKDPTGVLWHNFNNYDSKKMTGYVGLKNQGATCYMNSLFQSLYCTNLFRKAVYQIPTENDEPTKSVALALQRVFYNLQFSDVPVGTTEMTKSFGWDSLEAFMQHDVQEFNRVLQDNLEAKMKNTPADGAIKRLFVGTMKSYIKCINVSYESSRTEDFYDIQLNVKGCKNLEESFKDYIAEEVLEGDNKYMAEGHGLQDAKKGVIFESFPPVLHLQLKRFEYDIMRDTMVKINDRHEFPLEIDLEPYLDPVADRSQPHKYVLHGVLVHSGDLSGGHYFAFVKPTKDGNWLKFDDDRVVPTTLKEVLEENFGGDHVSGAMTNGRPSFRGFKRFTNAYMLVYVRESMIDEILANVVEKDIPSHLSQRLEQERQLQERKAKEKEQQHFYMKAYLVTDNTFMANDGFDFVNLEERSMETSQLEVRRVLKDQKYGDFKRELSHSMGLPETHIRLWFLVNRQNRTIRPDAPVPEGEEDCTLEEIRQKHLANQPNLRLYVEKSLSPDNERALFPPAPSNTSANALIFIKLFDPELQKIRGIGRLYINKADKVGSIMEQVNEIAGYEFGTPLVFYEEIKTTMIEEMDLNLTFTKAEIQDGDIIAVQRNLSDAEIEQLKEAGMYDNVPDFMDYQLHKLDVVFSPKDGNPETEFELSLHKNMRYDEVAAKVGAKIGADPEKIRFLACGPSGDLKPIRRTPTSLLADMQNMTYNQNVARFKLTYEVLDISLTEFESKRMVKITLCTPTLRDINVVELLLPKQGKIADLLKALDAKGAKFESAKGTRRTRIFEALGNKFNREFLPTDSISQLSASNYAQLYAEEIPEEEMLMGDDDIFIRVFHFQRDISRAHSVPFKFLVKKDEPFEETKKRLQARTGLNDKDWSKVKFNIVSSYSAVPIEEGDDFKLSNHLFTQEESLGLEHMDKTPRSARMGAERALSIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YIX4</accession>
    <name>A0A162YIX4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phenylalanine 4-monooxygenase</fullName>
            <ecNumber evidence="4">1.14.16.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phe-4-monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHYBLDRAFT_161646</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.16.1" evidence="4"/>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299055.1">
        <property type="nucleotide sequence ID" value="XM_018434439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YIX4"/>
    <dbReference type="STRING" id="763407.A0A162YIX4"/>
    <dbReference type="GeneID" id="28995345"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161646"/>
    <dbReference type="InParanoid" id="A0A162YIX4"/>
    <dbReference type="OrthoDB" id="983542at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004505">
        <property type="term" value="F:phenylalanine 4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04905">
        <property type="entry name" value="ACT_CM-PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03347">
        <property type="entry name" value="eu_PheOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.800.10:FF:000004">
        <property type="entry name" value="Tyrosine 3-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="entry name" value="Aromatic amino acid hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018301">
        <property type="entry name" value="ArAA_hydroxylase_Fe/CU_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041912">
        <property type="entry name" value="Euk_PheOH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019773">
        <property type="entry name" value="Tyrosine_3-monooxygenase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="AROMATIC AMINO ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473:SF24">
        <property type="entry name" value="PHENYLALANINE-4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000336">
        <property type="entry name" value="TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00372">
        <property type="entry name" value="FYWHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="Aromatic aminoacid monoxygenases, catalytic and oligomerization domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00367">
        <property type="entry name" value="BH4_AAA_HYDROXYL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00858">
        <property type="entry name" value="PREPHENATE_DEHYDR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="14">
        <location>
            <begin position="17"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Biopterin-dependent aromatic amino acid hydroxylase family profile" evidence="13">
        <location>
            <begin position="86"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAD81015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="432" mass="48996" checksum="CD028A55159E9C04" modified="2016-07-06" version="1">MFTSNKTQTSINSQKTTLCFSIADKVGALEDCLSAIKATNVSLTRIESRPSQTKDWDYDFFIDLDGVNAIKVKEVVEKLRAHTKDVRVIGAESTNGNVPWFPRKLSDLDSFADKVMEMGEELSSDHPGAKDPVYRARRAEITKIAKTYRTGMAVPEIKYTAEENETWGKVYKHLTAMYPTHACREHLYVFPLLIQNCGYGPDKIPQIEQISRFLKDCTGFTIRPVMGLLSSRDFLNSFAFRVFYSTQYIRHSSKPLYTPEPDCCHELLGHVPLFADPDFADFSQEIGLASLGASDEDISRLATIFWFTVEFGLCRQDGEIRAFGAGLLSSFGELEYCLSGKPEIRPFDPTKTAVQSYPITEFQPVYYVAESFKDAQEKVREFAANMKRPFSVRYNALTQSIEVLDSKEKVVRFARNIRDDMKTLTTVLDSMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZHG0</accession>
    <name>A0A162ZHG0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type zinc finger transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_152031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441000">
        <property type="protein sequence ID" value="OAD66761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284801.1">
        <property type="nucleotide sequence ID" value="XM_018432817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZHG0"/>
    <dbReference type="GeneID" id="28993723"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152031"/>
    <dbReference type="InParanoid" id="A0A162ZHG0"/>
    <dbReference type="OrthoDB" id="3247418at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="40726" checksum="78B674347E33D367" modified="2016-07-06" version="1">MSEINKAHDYMQSFCQQCLVIYKPGFLTCNIHLHLHFRETINNFGPVYGYWLFGFERYNGLLKKIDTNRKDGFEATYIKTFINDAYKGNYMRKVLICPSLVPFIPLLQKLTSSATTTANYDSYASYAFYASLSHQNFRLQQFVNIFLCPSPSTKGNKPLPLSSFPLRSLNALTMSDINYPQLLHFYQLVYANPGIVSYRNTSLCPYFVDNQITKLKSINLLGQIYKGKNSCENRGSFVQAMFLGGNNVTKTACTGQIQYLFIQSFTPLPHPNSPASQVHKKKHIFAYIRWLSITADKRRETESIDIYLPNFTPDNYHSILPVHRIDMEVATASEKTRNNIKKTLVIPLPKKYYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZHY9</accession>
    <name>A0A162ZHY9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_74201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD66901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284941.1">
        <property type="nucleotide sequence ID" value="XM_018443002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZHY9"/>
    <dbReference type="GeneID" id="29003908"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_74201"/>
    <dbReference type="InParanoid" id="A0A162ZHY9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="111" mass="12727" checksum="96F85F04DC8D70F0" modified="2016-07-06" version="1">MSKLLAFVFICIANLIQLKLDLVIFDLVIIVIYHIEQIYNIVKKHMQKCIYCLTSVGVTIMTSTLVLSTNLAPYRYDTVYPAMIATMLSQYEYVLICDKSNIQVSGSPQYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZZV2</accession>
    <name>A0A162ZZV2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anaphase-promoting complex subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cyclosome subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_171498</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288151.1">
        <property type="nucleotide sequence ID" value="XM_018436615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZZV2"/>
    <dbReference type="FunCoup" id="A0A162ZZV2">
        <property type="interactions" value="224"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162ZZV2"/>
    <dbReference type="GeneID" id="28997521"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171498"/>
    <dbReference type="InParanoid" id="A0A162ZZV2"/>
    <dbReference type="OrthoDB" id="2504561at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037679">
        <property type="entry name" value="Apc5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830:SF9">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12862">
        <property type="entry name" value="ANAPC5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="10">
        <location>
            <begin position="310"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="10">
        <location>
            <begin position="617"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD70111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="716" mass="82040" checksum="6EFEE0AECD701F17" modified="2016-07-06" version="1">MAICFKSKLHNVKDIPQDSRSPIEKYGKGVTKAEDLTAVNTDDFSYADTDNGLETDVSFRSKCFRKYGDKWKQKNRFATKPRDTLSALAIGLVGLSSVMFGAALPPFYNSRFGSYVVALEEEAVEEPSLREALRTLNASGMQKDIENIIEVINDNLAYINTPHNMNEIIQDTEKLLEEPVSDVTRHVHKDSPIGVYIRRCLAAYRMSSLLETTDIFAAFQAYVNGTSDDKIMHRLGSNELKPKLASFKQDDNVLDRIDGWITDDITVNFLDNQIRQIRDIGKSDCLPELLDKYLNFLQLYAPDIKKIDHVRALNLAQVKEYESASITFHKAVDTSLLSHENEHDQYSMLNLGILETRFGHFTEAIQSFSAALIIAQKKVDQHCLNEVQSWLRYVSSTDTYTGSSPPVNIKSEDIEEISRVIYHQSFYDLIWIRDALLHGRASNECFERLFQTIIRGGKSNVKGLSTFQNLVASQLWRHYGYGLLADNYLNAALDTEEEMIDNVEKKYIYAAEIFIAKGDYEKAQSMLNTFQTQYPSQSTMMIEWKQVQYRLDKYISQPIGPNTYRFVQEAMMPDYHPQNTSKYYDIKQNYAMEFYRCGDLEKSRVLLEQTLVGLKKEKLPLHIAINLMARAQLNMDIQCYSEAILLLKEVLRICKESNDAQNYYAAAIQLGHILVQQTPNDKREALFISQRLLPKVKSLESIELTTKCLALYEKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163A148</accession>
    <name>A0A163A148_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_182595</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288411.1">
        <property type="nucleotide sequence ID" value="XM_018438646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163A148"/>
    <dbReference type="STRING" id="763407.A0A163A148"/>
    <dbReference type="GeneID" id="28999552"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_182595"/>
    <dbReference type="InParanoid" id="A0A163A148"/>
    <dbReference type="OrthoDB" id="2209589at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15492">
        <property type="entry name" value="PHD_BRPF_JADE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="521"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="582"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="226"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="374"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="925"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="429"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="933"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="965"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1000"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD70371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1137" mass="128971" checksum="AA15E1D948CA00CF" modified="2016-07-06" version="1">MTTSSLFPDRYNSTNNNTLPANAASQQGTTYIRNRFHNGQPTRYVTTDTSNNNHNEDSDTEIDVVNNEDYTNNVNGETNGNGNNNAYENNYNSRKIVSNNNISIRHLTSPITHPENSLILPALRNQSGPRNMLASTPLPHNNNNNNVKHMHQKRRHQSGFTASSLIESYYSRLGNDLQNLSVKSRKVSTNDMSLPVEQPESTLISISDPVDNNYPEDSNCMSEYEDTYGEERRPEQSNHSRHSAYFSNPIHTTQSRRSTQPDFYNQTNHALDTQRDQSVENVVSGPIRRPEVYGIRYPLQRQEFEAQNGINRHRAMQEAHEEWVERQKYRRTYNLGGFGMPRMPQYSPNPRIVPGMAVTSSHRFHTSRLLTRPQPIQVPVKRPQQSSQPSSTWVGLDGYRMLNPEGAWNNDKSKDDRSQRHGLGLTENGNEHEHEYESQHGHNRTPSTILGKRGPETRYGENQNEFGYPGDRNTLAESGEREENVGSTSSDASNNCDGTVADGRWPSNVRNWLQKWKFNDPEVCCVCFMETCNEDNPFVYCDEPECDVIIHQKCYGIDKCPGSEDTWRCDRCESLKVNRSKMVICALCPTSHGAFRKLEGPFFGLGWVHVACALWIPGVYIADPDQIKGINLRSKCAVCPDPVQAEYGACVSCQEPGCDTMFHVSCGQKYGLVRITVSGKRSICCYNHDKRERFKRARPEQRMNLWDRWVETRDEYLESADGETGAKKEFLSAWHKAYKDISHDNIESSSEAFSKFCDNINTICNTRYKEAKAIITEGKARLAKLYENIQRHSSSRDQTALQIELKAVMTRIQRASESNRRNKRYYDDILEQATRLSFQLVLKNNDKSKPVSVQPLVQNPVNSPSSVQLNFVAEVFSPDLSANKAQKAVPRNPKKKDSSRLNKALVASTLVGSDSIFNWVDASPDLESKKKSGTQTKPPKPTVTGNKKLTGKKALNVITADPQVKRRSKTKSTKGPKPPKTPKQAISKQTVNANQKKKAEKPSKAAERSFKTPEELDNCICGECNQHDLPQEALDRLKLPEDYMKRLEETVHLRLNGYTGKGLNWDPRVFIECSACKGEFHCGCPNPPIKNYPAPHEIFVCVHCDTTAEDLEESEAQRDLRDSANRTRVKARINYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163A5X8</accession>
    <name>A0A163A5X8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_170654</name>
        <name evidence="2" type="ORF">PHYBLDRAFT_170655</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">NRRL 1555</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289321.1">
        <property type="nucleotide sequence ID" value="XM_018436396.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289322.1">
        <property type="nucleotide sequence ID" value="XM_018436397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163A5X8"/>
    <dbReference type="GeneID" id="28997302"/>
    <dbReference type="GeneID" id="28997303"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170654"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170655"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="205" mass="23746" checksum="096D34BB08C5CC73" modified="2016-07-06" version="1">MQSLLMLTNTINQENQAFCTVFKLLGGRSLTHIKKIIYPRSYKKSWKFNPVVNLSREKIVCSTISRLKYSSDQVNCIKLSKMHHQIIQPRSLPFHGSAKSTSRISTGSTISSNMNFIRWSKAVVSYIKKKVLAIPEWILQTILWHQYIYYRPPSASKKIFRKELRKHNSNNIAIQRNPALGVFSEKQHKAKLNPFQLGVTKILRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ABI1</accession>
    <name>A0A163ABI1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxisomal ATPase PEX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Peroxin-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PHYBLDRAFT_134259</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with PEX6; forming the PEX1-PEX6 AAA ATPase complex, which is composed of a heterohexamer formed by a trimer of PEX1-PEX6 dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290411.1">
        <property type="nucleotide sequence ID" value="XM_018429636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ABI1"/>
    <dbReference type="FunCoup" id="A0A163ABI1">
        <property type="interactions" value="466"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163ABI1"/>
    <dbReference type="GeneID" id="28990542"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_134259"/>
    <dbReference type="InParanoid" id="A0A163ABI1"/>
    <dbReference type="OrthoDB" id="2187at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19526">
        <property type="entry name" value="RecA-like_PEX1_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000149">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000105">
        <property type="entry name" value="PeRoXisome assembly factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015342">
        <property type="entry name" value="PEX1-N_C-lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF12">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09262">
        <property type="entry name" value="PEX-1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="413"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="694"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="936"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="937"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="952"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00064205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OAD72371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1017" mass="112131" checksum="C393B41913FB8E61" modified="2016-07-06" version="1">MPKQLLVTFTPIRSCLVHLPSPWANALIDQGKLPQNVMVELSWPSQGTTQKAYCGWSGEASKPLDPNAVFKYGNPPPDVLAIDPQFGQAIGISEGQLVNVEFCRNVPECVSVHVEPHTEDDWEILELHAGYVEDNLLSQIRAVYNNQLMCVWIHGRTLVRLRVAEISPASPYVKLTTNAEVIVAPKVRQSTKPADIAASKILSAQQQQAAPHVCLRNLPYTLPDAHGVWIHPDDSQESGLVRISKVIPAFAGRSQPSEDTQSEPHTDKDIKAVYASITLSTLVPRNHVHIESYLSDNDPIVLTHGMKIRLQVNGKSVACVIQLSPQKGLFSSTQTTAEQNIYANFTRAAVQKASINVGEDISKSSITKEEQPPTKPKKLITMGGVDTIYGQLHRYTHANLAERDLKSQLNVPGSGGVLVTGAHGAGKTSLVKKLMEDVYHDPGCLVYTITVQCSELVDERVPVFKDMLQKWFDEAAWCAPSVLFFDDLDRLIPAEVEHADSTRSRHLAELFSRMARTMTSRHPIMIIATSQQQQSLHPTMITHHVFTELRHVNPPTRDERKQIMHAIMSEGLDVLSQSLPNIDLVAVASDTEGYLAADLTALVERAVHESAVRNIRSYDATNPIATERLELTQQDFVSARQGFVPSSLRGVKLQSSTVQWTDIGGLHETRKALLETLEWPTKYAAVFSQCPLRLRSGLMLYGYPGCGKTLLASAVAKECGLNFISVKGPEILNKYIGASEKSVRDLFDRAQAAKPCVLFFDEFDSIAPRRGHDSTGVTDRVVNQMLTQMDGAEGLDGVYVLAATSRPDLIDPALLRPGRLDKALLCGMPSFEERLDILEALSHKMTLASDVDLTHYAQNTEGFTGADLQGFFYNAHLEAIHDSMDINSFREQQKKQGPKEEKNGFVMIGKAAVKTPLTLAEKGHISQRLAMIQQGEQNHKQSALKDEPKQEVSISNSHTAAIQQSHLDKSLKSTRPSITADERLRLQLIYDEFVTGRTGELKSGEGAKGVGKRSTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AEF4</accession>
    <name>A0A163AEF4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chaperonin Cpn10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_181675</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290951.1">
        <property type="nucleotide sequence ID" value="XM_018438502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AEF4"/>
    <dbReference type="FunCoup" id="A0A163AEF4">
        <property type="interactions" value="488"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163AEF4"/>
    <dbReference type="GeneID" id="28999408"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_181675"/>
    <dbReference type="InParanoid" id="A0A163AEF4"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000002">
        <property type="entry name" value="10 kDa chaperonin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD72911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14449" checksum="3B38E703FA230C2D" modified="2016-07-06" version="1">MEDFPRLFDSRTQSHRLNSSPSRPPPSFLSAATKIKNIVPLLDRVLIQRVKAQQQTASGIYIPEKAQEALNEGVVVAVGKGALTKDGKHIPLQVATGDKVLLPTYGGSIVKIQDEEYHLYRDSELLAKVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AX09</accession>
    <name>A0A163AX09_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_59899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294401.1">
        <property type="nucleotide sequence ID" value="XM_018440578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AX09"/>
    <dbReference type="STRING" id="763407.A0A163AX09"/>
    <dbReference type="GeneID" id="29001484"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_59899"/>
    <dbReference type="InParanoid" id="A0A163AX09"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="273"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD76361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="534" mass="61706" checksum="48513C1B4A728C64" modified="2016-07-06" version="1">MVRLKKQSTPEEDRLVSKFLKEDHAAPCKALSKGRCSWRDSTVPACVTIKPLLATLRKVKQVFDVYIESEHAPFKLSMEEGDQIETVRKENVFGEEVTASEMDIIQQRVALQQRQFAEYERRETNRKSKKIKEMYDYLTPEEIEEMLIDCGHDEDEVIVRLTQIGYLLGIRRVIATKHAPEVENNMMSEEQQAAYQQLLKKRSETLKKTTNDTAKKQYRMGGRLGLDEALKQIHENQVDPEKAFEGWSQARIRAYQMIDQNPNSYYYRFNAPGEVQRKGQWAEDERLVFFERLEELGANGQWGIFAMKVPGRVGYQCSNFYRLLVETGEVNDPNYVLDAKGKAHYLFDKKNADGQVEKTFRTHSKHGTGRVASPAGSRSRAAPVVEKKIKKRKRRTRGWDSDEDDDEHDFEDHNDDSGTFTLSTRSTRRTRARVDDSSGNNEDTNQEEDELDSDDMQLDNPLPGFVDPITLDEVVKPAISKYGHVMGYDSWVRCLSNWEGKKNICPLTKNPLTKRDLVVLTHENIEEYRSKIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B182</accession>
    <name>A0A163B182_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_164603</name>
        <name evidence="1" type="ORF">PHYBLDRAFT_169902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD71992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290032.1">
        <property type="nucleotide sequence ID" value="XM_018436201.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295751.1">
        <property type="nucleotide sequence ID" value="XM_018435043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B182"/>
    <dbReference type="GeneID" id="28995949"/>
    <dbReference type="GeneID" id="28997107"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164603"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169902"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD77711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="100" mass="11770" checksum="9A636C7ECB785A58" modified="2016-07-06" version="1">MNLVKNIKMNTVDPVFDFPYIIQLEMTLHVLSSVYKDNLSLLIYILATVKDIIRNAMDYQYQHLFFARSFPIFTMYFFSVDNYSIQTVSSRPVEAITDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B4Y4</accession>
    <name>A0A163B4Y4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_157511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296321.1">
        <property type="nucleotide sequence ID" value="XM_018433630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B4Y4"/>
    <dbReference type="STRING" id="763407.A0A163B4Y4"/>
    <dbReference type="GeneID" id="28994536"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157511"/>
    <dbReference type="InParanoid" id="A0A163B4Y4"/>
    <dbReference type="OrthoDB" id="10251727at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="28055" checksum="BE6DE97C30B70E0E" modified="2016-07-06" version="1">MKTSSSTLYDKDQVKKATHALWETYNDPEKPAFNPSQELWLNMTIKEASPQRSSKPKKISLKHAILNEKDKVCLITKECETRYNKLLKNEKSGYIEKIIGINTLETSYKSPESRCELASMLSIFFVDIRVVGQMKKVLGESFFGPNRAPIPIEIPRPKKINSTIIKHLKISSIMLSNGVTQSAKVGSLRMDEREAFDNVCSAIPGFVNIIKGGWENIMSITLKTDKSPELPLFISIPDKYVGGEDKNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BE19</accession>
    <name>A0A163BE19_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="6">G protein beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Gpb1</name>
        <name evidence="6" type="ORF">PHYBLDRAFT_104565</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299021.1">
        <property type="nucleotide sequence ID" value="XM_018427849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BE19"/>
    <dbReference type="FunCoup" id="A0A163BE19">
        <property type="interactions" value="148"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163BE19"/>
    <dbReference type="GeneID" id="28988755"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_104565"/>
    <dbReference type="InParanoid" id="A0A163BE19"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="58"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="146"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="187"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="315"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD80981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="350" mass="38659" checksum="32AAF2E087B739CE" modified="2016-07-06" version="1">MEEYEITSRIAVARRDAEALKERIKQRKDALSDTTCKNEMAKDIDSLPRVLMKNRKALKGHLAKIYSMHWATDRQHLVSASQDGKLIVWDAYSSNKVHAIPLRSSWVMTCAYSPSGDFVASGGLDNICSIYSLKIREGPVRPTRELSAHTGYVSSCRFIDDRRILTSSGDMSCMLWDIDAGVKTESFDDHTGDVMSLSLSPNPNVFVTGACDATAKVWDIRAAQCVHTFSGHETDINSVQFFPNGEAFVTGSDDATCRLYDIRADCELNVFTHESVLSGITSIDFSISGRLLFAGYDDYNCHVWDTLKGERVGVLTGHENRVSCLGVSGDGTVLCTGSWDASLKVIKANW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BGZ9</accession>
    <name>A0A163BGZ9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_73419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299571.1">
        <property type="nucleotide sequence ID" value="XM_018442850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BGZ9"/>
    <dbReference type="GeneID" id="29003756"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73419"/>
    <dbReference type="InParanoid" id="A0A163BGZ9"/>
    <dbReference type="OrthoDB" id="2253782at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16134:SF119">
        <property type="entry name" value="AT02038P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16134">
        <property type="entry name" value="F-BOX/TPR REPEAT PROTEIN POF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD81531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1273" mass="149097" checksum="712B8528624766BD" modified="2016-07-06" version="1">MRYSDLPFEILEHVSDYLSTNDKRSCSLTCKGWRYPFQKALWRYIRVKSYSGVQKLIRSIKKSQYVSTTYGLSVYSLRIYGSYLGIKTSDIEFSELFKHLPNLRCLHLELITYKRIYTDITSSDKIWTSLETLKIQWEYSSFEQEKINFFECIKACRMLQELEIRRGLRNELLYFSMNDFDNMPNNLKNLSSISVYINHNHDFLPTLDTIPNTAPVFSVASLNINWDEIRSSRNESWNIWSPLWLYYLGYKYPNLRSLRLNIKPPRMRVLNRDNSERTISLLRSNQNAFRHMETLDLIRDQDLELSKCILLELFIPLRVPLRHLTLDPGPLGDLNSSYSMDVIKVLESFSRTLQSFSARGFQLNLRDKDPSFKLYSYYPLLTNLCINNIDVYLDFGQLLDRCVALKELQFCAGTLVINPNTTTETSKQQQHGLQILTLRKCSGFIYEKTGCLLLNMPHTFLKTLTIGHIQYVPPYERTNVYNQSRLTLLSQLNDFPSSEDIGERKRNETDSEHHVLTSHRIAWIYTYYTFGPFENGRVKTTRLSKSGADIAFKYFQNFPPKCFFQTLEHKSLYDEEFDDMTRACELHKGYGQFKFGKIESVHVVNNTYFILLFNSPRSSSNILSFIKQVLIAPCIYLRSPPKAQVQPELPFEILAQIADRLSTDDKRSCALACKGLRHTFQRALWRYIRVHSYRGVQKLIDNIKRHQTVSTPYSLWVYSLRIYSSYSIAETSDIEFSELFKYLPNLRCLDLGPISYERIYTDITSSDKIWTSLETLKIQWEGNSYIHQRINFFEFINGCSKLRKLEIRKGSMNQLLEFSMKDFDNMHRHLKTLSSITVHVNPTSDFWTTLDTIPSTAPAFSVTSLNINWKQQRDRNGSWNSWNPLWLYYFGYKYPNLRSLRLNSRTMWPSTLIMDKRETMISLFRSNPNAFQHLETFDFKHDIYFKLSRFILWEVFRELRVPLRHLTLDPTQLGELDASYSMDVNKVLESFSKTLQSFSVQGFECISGVPNPIFGLYSYHPLLTNLCISSIDVTLDIVNLLDKCVALKQLKFCAGTLVIDPNTTTETSKQQQHGLQILTLRKCSVAFEVFNYVSSRCRCLKQMTLYTLHIKGSICKITGCLLLDMPHTFLKTLNVGQLRYGPSYEETNVYDHSRLTLLSQLNDVSLTDEKTKRDTNEIDPEHPALTSQRIDWLYTYNASPHYKYKRVKTTKLSKSGANIAFEYYQRFQSEKVLQNLKHQCLCNREIDYMEREYELNKGYGQLKFGKVESSRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163D5R0</accession>
    <name>A0A163D5R0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YCII-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_116847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286980.1">
        <property type="nucleotide sequence ID" value="XM_018428548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163D5R0"/>
    <dbReference type="STRING" id="763407.A0A163D5R0"/>
    <dbReference type="GeneID" id="28989454"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_116847"/>
    <dbReference type="InParanoid" id="A0A163D5R0"/>
    <dbReference type="OrthoDB" id="5519740at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051807">
        <property type="entry name" value="Sec-metab_biosynth-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606:SF3">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII-related" evidence="1">
        <location>
            <begin position="13"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="103" mass="11855" checksum="A0521AF6460F6F1F" modified="2016-07-06" version="1" fragment="single">KYSYLVIAKDFTDPGCLERRMAVRNQHLVEITEINKQGLVYVGGATLDSHESGKMTGSAIIAWSDSVEQLKDRIENDPYYKGKVWEKYEIYPYRIAIHGETKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DAR5</accession>
    <name>A0A163DAR5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_115995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD70020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288060.1">
        <property type="nucleotide sequence ID" value="XM_018428490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DAR5"/>
    <dbReference type="STRING" id="763407.A0A163DAR5"/>
    <dbReference type="GeneID" id="28989396"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_115995"/>
    <dbReference type="InParanoid" id="A0A163DAR5"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12339">
        <property type="entry name" value="RRM2_SRSF1_4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF51">
        <property type="entry name" value="SERINE-ARGININE PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="87"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD70020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="186" mass="21619" checksum="B3A624347CAD38E4" modified="2016-07-06" version="1">MGYRVYVGRLSHDATKEDLEGLFKKYGKLLDVTVKTGFGFVEFSDKIDAEDAVHDINDTRFLGQRIVVELAMNRRRDDRRDDRRKVYRVIVKNIPPKTTWQDLKDYMKKAGHVAFADVLKGRNGEGVVEFSKREDMKYALRKLDDGRLNGQRISLHEPVSLFLILFLSCLTLFYFGIACFNCVYNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DHD9</accession>
    <name>A0A163DHD9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYR N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_147734</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289270.1">
        <property type="nucleotide sequence ID" value="XM_018431938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DHD9"/>
    <dbReference type="STRING" id="763407.A0A163DHD9"/>
    <dbReference type="GeneID" id="28992844"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_147734"/>
    <dbReference type="InParanoid" id="A0A163DHD9"/>
    <dbReference type="OrthoDB" id="285793at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003889">
        <property type="entry name" value="FYrich_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003888">
        <property type="entry name" value="FYrich_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040092">
        <property type="entry name" value="TBRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22715">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR BETA REGULATED GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22715:SF0">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR BETA REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05965">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05964">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00542">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00541">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51543">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51542">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD71230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="32054" checksum="910194ABA52A42DC" modified="2016-07-06" version="1">MITKHAAVDAESQSDNQWNDDRMRKYRSLKRKMIEFIAKQRSAQLTIDKANRRIQALQRENRRLLHKSKGKGDAMDASPIGDEDDAGEDDEDAEKNEEEDQLDENEDEEMFGYTDDMVLQPKRNSASRKRQEIPRDSEGNVIFPFSFASLKVLNLGTIMINQPAFHNDRYIYPLGYSVERTYMSMVNPDSQTTYTCTVKEQDNAPLFTIRAADAPSHEISGQTPTGAWSLVIKQANLIRQKDSTNAISGPEYYGFSHPLVIEMIEELDGVDKCSRYIRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DQ99</accession>
    <name>A0A163DQ99_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_78011</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290870.1">
        <property type="nucleotide sequence ID" value="XM_018443324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DQ99"/>
    <dbReference type="STRING" id="763407.A0A163DQ99"/>
    <dbReference type="GeneID" id="29004229"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_78011"/>
    <dbReference type="InParanoid" id="A0A163DQ99"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007842335" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="3">
        <location>
            <begin position="46"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD72830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="145" mass="15576" checksum="3625AAFF1BE4000D" modified="2016-07-06" version="1">MRFSYLAILLISLAFVLADAAAVENVEKISRAQKTIIQKRSQTYSGKATWFIPSKEGGSAGACGPNEADDAPIVALNHPQYGSMSAKSSWCGKKILITNGKKSVTATINDACPECAHGDLDLTPVLFEKLGDLNTGILQIKWHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DYL2</accession>
    <name>A0A163DYL2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_167644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292260.1">
        <property type="nucleotide sequence ID" value="XM_018435681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DYL2"/>
    <dbReference type="GeneID" id="28996587"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167644"/>
    <dbReference type="InParanoid" id="A0A163DYL2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="118" mass="13706" checksum="72423F93171E981A" modified="2016-07-06" version="1">MYRNKNLPITLTLTWPHKYVNFPDFTQAQKLQIKQLHDKEGIKDLGTIIKACSNVEIPIDTFELSVKIRTVCVCSTTYYALLNIPEFQSKKVDKVNILVVALRYIRFEYNQNIPSVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163E128</accession>
    <name>A0A163E128_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_155094</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292670.1">
        <property type="nucleotide sequence ID" value="XM_018433383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163E128"/>
    <dbReference type="FunCoup" id="A0A163E128">
        <property type="interactions" value="376"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163E128"/>
    <dbReference type="GeneID" id="28994289"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_155094"/>
    <dbReference type="InParanoid" id="A0A163E128"/>
    <dbReference type="OrthoDB" id="239812at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="ATP SYNTHASE GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693:SF22">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039089">
        <property type="entry name" value="ATP_synthase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="ATP synthase (F1-ATPase), gamma subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9 11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD74630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="267" mass="28909" checksum="3C37EB75DBE3D228" modified="2016-07-06" version="1">MATLREIQQRLRSVQNIEKITKSMKMIASTKVAKAQRNMETARAFGVASNSLFQSAETKATEGGSELIVASSSDRGLCGGIHSSVSKATRRAVEANPEGRVVVLGDKPKAQLSRSVRSNITLSFNQIGKAVPTFTEASSIVDVIKADGIEFDSAKIVYNKFLSAISYEADSITVYSQDAFKASPNFAVYEIEDDVLANLQEFNFANSVYWAMVEGHAAEMSAKRAAMENATKNAGEMITKLTMTYNRGRQAVITNELIDIITGASAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163E8W7</accession>
    <name>A0A163E8W7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_164315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295440.1">
        <property type="nucleotide sequence ID" value="XM_018434987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163E8W7"/>
    <dbReference type="GeneID" id="28995893"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164315"/>
    <dbReference type="InParanoid" id="A0A163E8W7"/>
    <dbReference type="OrthoDB" id="2288452at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="38950" checksum="53612398514B1836" modified="2016-07-06" version="1">MNNFTSNSPSENNFVHAAIARNIMPNSNTGLASVMYTPTTRPAGSHVDGNVADPVLAMLACLNAQMKSLTDQIASMATSITKSNDTTTCLQETVANIVSGQTVVQNTASRYNVTSGVEAVTGLSSLMEDDYVPGKRHPAISKLINGYLKKRNFSSSDQRKVATNAAKPGWVLTSYFTGGYNHSLALALTAYLRSQPQSAGILTSDLACIVKNHFCNQIHESRRRLHLQTEKELHQEDISMLLCQRSMAYLENKEAIDTVTKRDNCAHVLQNAAMSDDETDDEATRLASSKRLKAYRPNWRSDELQTLLERLDDYAVAKGQQRSLKLIPRIRVTCDADVPNDLKVPLAQWTIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EH13</accession>
    <name>A0A163EH13_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_90328</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296630.1">
        <property type="nucleotide sequence ID" value="XM_018443749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EH13"/>
    <dbReference type="FunCoup" id="A0A163EH13">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163EH13"/>
    <dbReference type="GeneID" id="29004654"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_90328"/>
    <dbReference type="InParanoid" id="A0A163EH13"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD78590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="235" mass="27255" checksum="E801A8B71E74AB09" modified="2016-07-06" version="1" fragment="single">EREHRTQREMAIMQLLRHPNICQLKEWMTEGDRYYMFLEYVDGGQLLDYIISHGKLREKQARKFSRQIVSALDYCHRNSIVHRDLKIENILITRDENIKIIDFGLSNIYSPLRQLNTFCGSLYFAAPELLQAHKYIGPEVDVWSLGIVLYVLVCGRVPFDDTSLPALHAKIKAGVVVYPDHLSKDCIHLLSNILVVDPLQRKDLSFVRNHPWLNKGHDAPVDNHLPHRLPLTTPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167J937</accession>
    <name>A0A167J937_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_176110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441010">
        <property type="protein sequence ID" value="OAD65519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283559.1">
        <property type="nucleotide sequence ID" value="XM_018437660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167J937"/>
    <dbReference type="GeneID" id="28998566"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176110"/>
    <dbReference type="InParanoid" id="A0A167J937"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="161" mass="17070" checksum="D5535A38F454E056" modified="2016-07-06" version="1">MSSNSSRKTDHKGKGKASASISTSANRVLAGHVGPQEIAPSFSSTTIQDQQYAEIVEMFSKVNNSINGVKDDIAAVNSNMTAFKNRMGVVVDTSGKTYTAFADFATAYTNNQTGMASLGPSLMPSYVPQTSLSDAKVSVIILFLQVYEAGLLIGGKTNFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JR28</accession>
    <name>A0A167JR28_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_78792</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441002">
        <property type="protein sequence ID" value="OAD66537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284577.1">
        <property type="nucleotide sequence ID" value="XM_018443389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JR28"/>
    <dbReference type="STRING" id="763407.A0A167JR28"/>
    <dbReference type="GeneID" id="29004294"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_78792"/>
    <dbReference type="InParanoid" id="A0A167JR28"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="34"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD66537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="324" mass="37119" checksum="60677EAD70D5E4D8" modified="2016-07-06" version="1">MLDKYDPSTCNNQFCNTNGIRMHYVDENPSSKEVLLLIHGWPDLWLGWREQIGFLVNLGYRVVVPTLRGFGETESPADPSLYGFKTACKDIVGLLDHLEIPTVTTIGHDWGGFVVWRFSQFYPERVKAIASFCTPYGPRPPVRLTLEQVVQNLPNFKYQLYLCTPEAEQEINAYPREFFTALFRTVNEQSGRKLLDLKTGKLVEGRPAVKKSDLVPQKVLDHYVEMVKKHGSRGGLNWYKQVLRNWDESEGLDPIITKPSLMVLAERDVALPPSMAANMKNYVPNLETHLVKDAGHWILWEKPEECNRILAHWLKSLNIVPSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JX23</accession>
    <name>A0A167JX23_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_6352</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441000">
        <property type="protein sequence ID" value="OAD66846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284886.1">
        <property type="nucleotide sequence ID" value="XM_018441132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JX23"/>
    <dbReference type="STRING" id="763407.A0A167JX23"/>
    <dbReference type="GeneID" id="29002038"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_6352"/>
    <dbReference type="InParanoid" id="A0A167JX23"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="5"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD66846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="201" mass="22816" checksum="D48DB03CE9A8C0BB" modified="2016-07-06" version="1" fragment="single">GIGPYTFCHALGNGKFSRVMLAKHKNGTLVAIKMIDKQAHDYRVMSRLVREIYLMEALDHESVVRLYETFETCDTLYLVMEYVPGCNLDEHLQKSGGSISEDEARLIFRQMVVAVSHCHSRWVVHRDLKTPNVLVAPDGIVKLADFGLGNRFGLQRLRTICGSMLYYSPEIISGQKYYGPEVDCWCLGIALFRMTAGFEPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K3J4</accession>
    <name>A0A167K3J4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase type 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_32217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441025">
        <property type="protein sequence ID" value="OAD67206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285246.1">
        <property type="nucleotide sequence ID" value="XM_018439992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K3J4"/>
    <dbReference type="STRING" id="763407.A0A167K3J4"/>
    <dbReference type="GeneID" id="29000898"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_32217"/>
    <dbReference type="InParanoid" id="A0A167K3J4"/>
    <dbReference type="OrthoDB" id="416496at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050508">
        <property type="entry name" value="Methyltransf_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912:SF83">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="2">
        <location>
            <begin position="88"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD67206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="264" mass="29830" checksum="CA02038B75BB1774" modified="2016-07-06" version="1">MVVFKSKGDTAANTTTTTDTTAPSESAAPKTTVLKPIETKVTPSQFDTSPIWESVAKSYDNEIGWDERVMGIGLLRRWLVSQAKGDVLEVSTGTGRNFSYYKPESITSATFTDRHPPMLEEAKHKFEKQPKPWNVEANFITANVDDPKSMPQGFDTVVDTFGLCSCGDPVEALVSLADACKSEDSRILLLEHGRSHYDWLNRLLDTNVDKHVTRWGCWWNRDMVGLLEDKRVKEKMEVVSMYRWHFGTTCYIVAKPKRSPTETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K484</accession>
    <name>A0A167K484_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_63758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285288.1">
        <property type="nucleotide sequence ID" value="XM_018441176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K484"/>
    <dbReference type="STRING" id="763407.A0A167K484"/>
    <dbReference type="GeneID" id="29002082"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63758"/>
    <dbReference type="InParanoid" id="A0A167K484"/>
    <dbReference type="OrthoDB" id="2283240at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33977">
        <property type="entry name" value="ZINC ION BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33977:SF1">
        <property type="entry name" value="ZINC ION BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="15300" checksum="04DB9329F7F32027" modified="2016-07-06" version="1">MIDCSSAEIRAIGKVFRNEVDLILRHWHIKRAWEVNIKVVNSTQDSNIACNIIQAALNNMMYASTSVAFNNLYNSFLEKCKDYETFIAYFEKMGIPKKQLWSKAWRQLVTFHMNNFIESYHNQLKTFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K7C3</accession>
    <name>A0A167K7C3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_151315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285456.1">
        <property type="nucleotide sequence ID" value="XM_018432665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K7C3"/>
    <dbReference type="GeneID" id="28993571"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151315"/>
    <dbReference type="InParanoid" id="A0A167K7C3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="117" mass="13053" checksum="6F3A13F43C826F4C" modified="2016-07-06" version="1">MPPFSELTFNSPSHITKRTPPNKKSRDVNLSSLACAMNNLSSPPIKADPSSTGRRPVLTSWKRTEWGGDRERWGVRLAMGLKNKREGKLNYPTPTTPTTPTTPPIHTTPTPIHPTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K7M2</accession>
    <name>A0A167K7M2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_151331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285469.1">
        <property type="nucleotide sequence ID" value="XM_018432670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K7M2"/>
    <dbReference type="GeneID" id="28993576"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151331"/>
    <dbReference type="InParanoid" id="A0A167K7M2"/>
    <dbReference type="OrthoDB" id="2439595at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="233"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="610" mass="69497" checksum="A5D2216184EF1615" modified="2016-07-06" version="1">MRLIKKYLPDSPNYHQPNTSNQKPFISASYSNPASSQSSLFFDTDSCRSGDIATIKDILSHEPQKPRTSIRNKISDFAEKLPVVTQNKSRRPEEIQAELDEQKKYSNLFGITQAKNNGTERSYPNSFQPENLAGILNADLFTELVKYMKNNAADNKTVHALIDQETTEESVKKDAEYDFEYTLKKNLDKINTKYAVLCKANTSLKRGIKNAEKSKETITCQAQLRDMNYQKEIRDLQDSLAATKLELAGEKENSEILNKSIGLLKGENDKLKDDNDTLKNENDTLREENDKLKEKNTEILNQAQSRERRCERIINSLRLQSTTSQAELIEKKMEYQILLSEFQSHVDTVPTAEDDLFTIHAKLNIVQTKISDLCMSLEDFLNPNEGEVYNIFFDNWKEDSFRYKVLMEKRGDGSYGFDYGIISLLVESFITEYLINEVYDVPIYLGLPINTAYTELSEWEPFKNCANWSRKLRKQLCSLASRPEISEKLNENRAQVTRNILKPLSAIFTRITPATITKVTAIVNLASQISLAMHSQDVPVKCIKLKEGKDKINNTMRSLYGSIEGETTIQIVVCPPFIANEGQETESVLLEGKVICFERPQKGKTLAVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KHJ7</accession>
    <name>A0A167KHJ7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_158746</name>
        <name evidence="2" type="ORF">PHYBLDRAFT_160237</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286156.1">
        <property type="nucleotide sequence ID" value="XM_018434146.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291659.1">
        <property type="nucleotide sequence ID" value="XM_018433851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KHJ7"/>
    <dbReference type="GeneID" id="28994757"/>
    <dbReference type="GeneID" id="28995052"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_158746"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160237"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD73619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="94" mass="10093" checksum="F22534E9E6B12292" modified="2016-07-06" version="1">MTPSSLSPHYAAQSPSGRKPDLVAKEVLEWWQTNGKHPFIQPHISSPSNVGANSPENLPLGDKVQLIRLPVASPSAVKEFSQVSSEEPAHLTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KLH3</accession>
    <name>A0A167KLH3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Efficient mitochondria targeting-associated protein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_32988</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM97/sigma-2 receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286406.1">
        <property type="nucleotide sequence ID" value="XM_018440003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KLH3"/>
    <dbReference type="FunCoup" id="A0A167KLH3">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167KLH3"/>
    <dbReference type="GeneID" id="29000909"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_32988"/>
    <dbReference type="InParanoid" id="A0A167KLH3"/>
    <dbReference type="OrthoDB" id="433124at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051987">
        <property type="entry name" value="Sigma-2_receptor-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016964">
        <property type="entry name" value="Sigma2_recept"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204:SF1">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031032">
        <property type="entry name" value="TMP_97_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="9">
        <location>
            <begin position="9"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD68366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="169" mass="19572" checksum="A26BAB1C8A79F1D8" modified="2016-07-06" version="1">MTRLSERRLDLIFFTYFATHIPITALIDLQSIYPSFLVPSFLKNVVAWYLEQFKDPIMAGPAKPWFLSFILCEAFIQLPFFFYACYGLYYNTSSIRLGLAVYSSHVMTTVLPVLVDLWFNPEYDLSLPTIGVLYMFYAPYFILPLIMLIDSCLKVSKQTSATVKHEKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L0D5</accession>
    <name>A0A167L0D5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="4">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate phospho-hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_66734</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287339.1">
        <property type="nucleotide sequence ID" value="XM_018441682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L0D5"/>
    <dbReference type="STRING" id="763407.A0A167L0D5"/>
    <dbReference type="GeneID" id="29002588"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_66734"/>
    <dbReference type="InParanoid" id="A0A167L0D5"/>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000004">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD69299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="312" mass="35180" checksum="A820C4C00AC1B46A" modified="2016-07-06" version="1">MNFLITGMRSNNLNFHSATRMSIRAMSNYTRLATGTPFTESHRIYIEKDGQIISPFHDIPLFTNTEKSVLNMVVEIPRWTNAKIEVATGEEFNPLKQDVKKGKVRFVRNCFPYKGYLWNYGALPQTWEDPTQSNPDTNARGDNDPIDVCEIGEKLGVAGEVKEVKVLGVMALLDEGETDWKVIAIDTKDPLANKVHDIKDVETHFPGLLDATYRWFKIYKVPDGKPENEFAFDGQCKDKAYANTIIEETHEAWQKLIKGDTPAKADTHDLAVANVTIKGSPYTTSSKSIKPSQEVKKSNNPGEADNKWYYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LF89</accession>
    <name>A0A167LF89_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_171709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288365.1">
        <property type="nucleotide sequence ID" value="XM_018436649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LF89"/>
    <dbReference type="FunCoup" id="A0A167LF89">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167LF89"/>
    <dbReference type="GeneID" id="28997555"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171709"/>
    <dbReference type="InParanoid" id="A0A167LF89"/>
    <dbReference type="OrthoDB" id="9973183at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23812">
        <property type="entry name" value="UBCc_ScPEX4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="3"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD70325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="163" mass="18531" checksum="E08C31178AA44EF1" modified="2016-07-06" version="1">MDSVSRRLLKELRAYEKESRAHPEILELSPETDDDLLVWRAKLAGLPETPYEGGVFDLSITIPRNYPIQPPTIRFITTICHPNVHFKTGEICLDILKTEWSPAWTLQSTILAISLLLSNPEPSSPLNCDAANLLRCDDRLAYDSLVRMYTQLYAVPFEGEKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LNJ3</accession>
    <name>A0A167LNJ3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1279 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_148021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288838.1">
        <property type="nucleotide sequence ID" value="XM_018431993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LNJ3"/>
    <dbReference type="FunCoup" id="A0A167LNJ3">
        <property type="interactions" value="235"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167LNJ3"/>
    <dbReference type="GeneID" id="28992899"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148021"/>
    <dbReference type="InParanoid" id="A0A167LNJ3"/>
    <dbReference type="OrthoDB" id="426386at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045866">
        <property type="entry name" value="FAM210A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009688">
        <property type="entry name" value="FAM210A/B-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377:SF0">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06916">
        <property type="entry name" value="FAM210A-B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1279" evidence="2">
        <location>
            <begin position="80"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD70798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="197" mass="21478" checksum="779CB0A88AA4DC4D" modified="2016-07-06" version="1">MSRNIFIRAFSGVIPLTAPYQRPISSRLTFIPRTRFMTTKASSSMPKHTSKSTPTPMPTPTPTPSASVSSSSSPSPPQGKIKQFTKKYGPMGVSVYFALSVIDLSLTMAVISVKGADQAKQAEEWVLQKVKGWLGMSHTPSKIEKGEPSFGSLFVIAYGIHKTILLPIRLSLTAAITPIVAKRFKQWGLQKASKQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LP82</accession>
    <name>A0A167LP82_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_77593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288876.1">
        <property type="nucleotide sequence ID" value="XM_018443275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LP82"/>
    <dbReference type="GeneID" id="29004180"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_77593"/>
    <dbReference type="InParanoid" id="A0A167LP82"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="136" mass="15885" checksum="2F120A5FCC165148" modified="2016-07-06" version="1">MDSQFEKEEDTTNQFDSDTVTINKFIFCTRHGKEVCDKCPTDNRNCNNETIGDVLERLTKEERETKWKGDDRDPFVISHKWVRYNGKPACTAHREVGCNECFNWGEQIYKGIHGGRKPRVSRLANKKNRENKDVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LTT9</accession>
    <name>A0A167LTT9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ISXO2-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_148305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD71088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289128.1">
        <property type="nucleotide sequence ID" value="XM_018432069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LTT9"/>
    <dbReference type="GeneID" id="28992975"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148305"/>
    <dbReference type="InParanoid" id="A0A167LTT9"/>
    <dbReference type="OrthoDB" id="5598606at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053164">
        <property type="entry name" value="IS1016-like_transposase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163">
        <property type="entry name" value="DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163:SF2">
        <property type="entry name" value="SI:DKEY-17M8.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="27348" checksum="3EA1BEA8C2EB9666" modified="2016-07-06" version="1">MNYQSSLSVRPLSIPPLSYVMASTYTFEVAKHSMDYIFEKDRDYSYRCSEVNSMGATYCKRERKSERLDSFFAQSHLSYDVVMQEIYYWLNRIPRMTMGVMLDVSPETIRHLIASIHQLIQMDLTNNDMRIGGIDVNSQFIIVEIDESKFGKRKHHQRHRVEGVWVLGSTEKTAERKTFLVTVPQRDAATLLQAVYGGLSSVVDMNYTHRTVNHNVEYVISDGLWNGIKMNCKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MH86</accession>
    <name>A0A167MH86_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_113395</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCO1/2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290876.1">
        <property type="nucleotide sequence ID" value="XM_018428341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MH86"/>
    <dbReference type="FunCoup" id="A0A167MH86">
        <property type="interactions" value="214"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167MH86"/>
    <dbReference type="GeneID" id="28989247"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_113395"/>
    <dbReference type="InParanoid" id="A0A167MH86"/>
    <dbReference type="OrthoDB" id="270009at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017276">
        <property type="entry name" value="Synth_of_cyt-c-oxidase_Sco1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF5">
        <property type="entry name" value="AT19154P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037736">
        <property type="entry name" value="SCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="9">
        <location>
            <begin position="87"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD72836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="25035" checksum="9C3E539D07D88C53" modified="2016-07-06" version="1">MFSGQRFTWKAAGLFVATGVGLAVYFKNEKERVTKERKKKEYEANRSFGKPNIGGPFTLINAATEKPFKDTDLHGQFHLIYFGFTHCPDICPEELDKMSDVIPGSKKEDLPVVPVFITCDPRRDTPAIVREYVKDFHPAMVGLTGDIDTIKRVAKSYRVYISIPDEEDDYLVDHSIFFYLMDPQGEFVDCYARDKTPEEIVESFKTYKQEYLERGGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MPF9</accession>
    <name>A0A167MPF9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zn(2)-C6 fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_145835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291486.1">
        <property type="nucleotide sequence ID" value="XM_018431542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MPF9"/>
    <dbReference type="STRING" id="763407.A0A167MPF9"/>
    <dbReference type="GeneID" id="28992448"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145835"/>
    <dbReference type="InParanoid" id="A0A167MPF9"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15486">
        <property type="entry name" value="ZIP_Sip4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="444"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="171"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD73446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="753" mass="86163" checksum="94D5B12C0C0FC098" modified="2016-07-06" version="1">MLPFDANDRPRSQSSPQSSMYHGHDLTACNNLPTMPHVTNPMTRPQDSQQFVIQMLPTNATAQHVYDQLNSIPKERTRKDRACDLCRRKKISQLTPNKPCSSCDNYKKMCTFNEAGKKRGPPKGYVEKLESRLKRMEDLLMNMSDNGNESSDSIKALLKGKEVDISEDIEQAYSDESDTDIQTNESANTKRKNSEESENSEDQWRKRREITYSPAQNPQTTSNQSVSPSLHKSAAPSPRNCGAQNSPYSTDSENPGYNDSFMGSSSGVYLLGKLFEMTGRNMKDLTHDIAKPLDNHEDDLIISISKTGIFKEDLFNFPHGNDSVPWRLPPKEVIDHLVDIYFTQMNIFVPIVDEESFYDTYRNDFDSQSMVLLAAICRSSCRIMDENNPSARKNYITRVQLYDSLTEQIKEKFDLDLIQPRIETIQILLLGACNATKWSADGVDWIAMSMAIKLAQELGLHRSRSTCGATKETIKFYKRLWWSAYVIDRWICGCLGRPLMISDADCDVDLPEIDSETEEPLPSNKYITFFYLVKLSEILSDVLRTLCSPRARIVNHNEEIYNQARVNIERMLKEWEQTLPSNLKITEEEFDMIRRKELSPELAQKINSGSGQLYLGYCAVNLQVKRPFLLPDSKLKKNEKILSGCMKYMERAIEILDVIDVQTFLQFGWSISSFVLAQVYTFVLFSHQNNDKTTAELANRQLFILSYMYKRLEAYITEPSMMPVLELMCKTVNESYTTSNNNKNTTMLPPSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MPG9</accession>
    <name>A0A167MPG9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_158939</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291489.1">
        <property type="nucleotide sequence ID" value="XM_018433881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MPG9"/>
    <dbReference type="STRING" id="763407.A0A167MPG9"/>
    <dbReference type="GeneID" id="28994787"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_158939"/>
    <dbReference type="InParanoid" id="A0A167MPG9"/>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008251">
        <property type="entry name" value="Chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01393">
        <property type="entry name" value="Chromo_shadow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00300">
        <property type="entry name" value="ChSh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD73449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="178" mass="21089" checksum="A7998D6A7ED45ADE" modified="2016-07-06" version="1">MSFQPDDIAESILRHKENNGVIEEYNIKWLGYDVDASTWESAHVIETDFPALAYKYKNKVIQEKKQLQSIENAIRNEEKKETEDFDSEDYMDFIENITDWETEVDHIASVERAQYAGLVVYIVWKNGKKTIHHSTEVYAKCPERMLDFYESKIIRAKVTQKDLEKTKRNFRNNGSRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N6C3</accession>
    <name>A0A167N6C3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_144471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293160.1">
        <property type="nucleotide sequence ID" value="XM_018431225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N6C3"/>
    <dbReference type="STRING" id="763407.A0A167N6C3"/>
    <dbReference type="GeneID" id="28992131"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144471"/>
    <dbReference type="InParanoid" id="A0A167N6C3"/>
    <dbReference type="OrthoDB" id="2434996at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="125" mass="14103" checksum="38F6E382362F1E30" modified="2016-07-06" version="1">MCNNNPTRVASANFDLLKQALSKFLAQLVKVFLFEPLDGQVVDAPPEPLWVLICSQRDDYMAIVNQIIVQQPADIQSRLLFAFQTLDQATPTQLAYSLPPSRNAPKFREALLSFLMDVRAVLRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NIZ1</accession>
    <name>A0A167NIZ1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Squalene synthase</fullName>
            <shortName evidence="15">SQS</shortName>
            <shortName evidence="15">SS</shortName>
            <ecNumber evidence="4 15">2.5.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHYBLDRAFT_123357</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 (2E,6E)-farnesyl diphosphate + NADH + H(+) = squalene + 2 diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:32299"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 (2E,6E)-farnesyl diphosphate + NADPH + H(+) = squalene + 2 diphosphate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:32295"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.21" evidence="4 15"/>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294078.1">
        <property type="nucleotide sequence ID" value="XM_018428921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NIZ1"/>
    <dbReference type="FunCoup" id="A0A167NIZ1">
        <property type="interactions" value="279"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167NIZ1"/>
    <dbReference type="GeneID" id="28989827"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_123357"/>
    <dbReference type="InParanoid" id="A0A167NIZ1"/>
    <dbReference type="OrthoDB" id="431150at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045338">
        <property type="term" value="P:farnesyl diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000003">
        <property type="entry name" value="Farnesyl-diphosphate farnesyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006449">
        <property type="entry name" value="Squal_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01559">
        <property type="entry name" value="squal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626:SF2">
        <property type="entry name" value="SQUALENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAD76038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="417" mass="47634" checksum="11E0C7E0B3C6B6D8" modified="2016-07-06" version="1">MSVFLKSLGHPSELKALLAYKFAPASQNKLNHQKTMANDEQKKKCYQFLDMTSRSFAAVIQELDDELRDAICIFYLVLRGLDTVEDDMTISLEKKLPLLRSFDKIIYQRGWNFNENGPNEKDRELLVQFDVVIEEFLRLKPGYQRVISDITEKMGKGMADYAAGEHRENTSVATIKDFDLYCHYVAGLVGYGLSDIFAESGLEDKSIAKDKVKANNMGLFLQKTNIIRDYREDLDDGRQFWPREIWANYVTEFKDLTLPSNSEKARHCSSAMVLNVLHVVPDVLSYLSNLHNQSVFNFCAIPQVMAIATLALVFNNLDIYHKNIKIRKGEAVRLISASTNMDNVVEIFREYLKVISQKNDPLDPNFLEISMALGKIEQWIVANTKSQRAVVKPNGSQLLPIAVCLAAIFYFYFYQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NKR5</accession>
    <name>A0A167NKR5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHYBLDRAFT_132201</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294198.1">
        <property type="nucleotide sequence ID" value="XM_018429473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NKR5"/>
    <dbReference type="FunCoup" id="A0A167NKR5">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167NKR5"/>
    <dbReference type="GeneID" id="28990379"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_132201"/>
    <dbReference type="InParanoid" id="A0A167NKR5"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000016">
        <property type="entry name" value="Solute carrier family 25 member 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="123"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="190"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="293"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="415"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAD76158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="508" mass="56353" checksum="FE7C05048CBFB9AC" modified="2016-07-06" version="1">MNQHSDQPRHPYYDEKVAERENRVKNLFDSLDTNNTGYLDADAIIRGFLKLTHLPTHTSYATDLLAKCNTSRDGLIDYEEFRAYVLEKERELWALFSEINKSNDHRLRAGDLKSALKAAGVCVTEDDIEQFIQAIDTEGNGYIDFQDWRDFLLLLPQDTTIIEIYKYYQTSTQLTPDAEVVFPHTDEAVGNAYKYLAAGGIAGAVSRTCTAPLDRLKVYLITQTSYQAQAKAPMSITAALKHIYSQGGLRAFFVGNGLNVVKIVPESAIKFYVFETAKSIMAELTNSEDKNGIPVSARFIAGGMAGLCSQFCIYPVETLKTRIMANHGGSPVAIPNPHMPCTSGKPQSYIFLTAKEMYKTKGIRAFWPGLTLGLLGVFPYQALDMGIYETLKVTYLQHMNKQAAEHRQTGEAPQPNVLVLWTCGMVSGSIGATSVYPLNMIRTRLQAQGTAGHPHRYNSAFDAVKKTFQADGIKGFYKGLGPTLFKVVPSVSISYAVYEFSKRSLGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NV94</accession>
    <name>A0A167NV94_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rab escort protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_180189</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294724.1">
        <property type="nucleotide sequence ID" value="XM_018438276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NV94"/>
    <dbReference type="FunCoup" id="A0A167NV94">
        <property type="interactions" value="159"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167NV94"/>
    <dbReference type="GeneID" id="28999182"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_180189"/>
    <dbReference type="InParanoid" id="A0A167NV94"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000003">
        <property type="entry name" value="Rab proteins geranylgeranyltransferase component A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001738">
        <property type="entry name" value="Rab_escort"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF4">
        <property type="entry name" value="CHM, RAB ESCORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016550">
        <property type="entry name" value="Rab_ger_ger_transf_A_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD76684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="590" mass="65934" checksum="1B07A79BF9AED2D1" modified="2016-07-06" version="1">MSNENLQLEETHFDVIVLGTGLVESITAGSLARAGQKVLHLDSNPFYGSNWSVFGFRELLEWSESAQNSNEDPNIPSHTKSPVDAETFTIEYEKSCRENFKNVEFCLYGSRDTESPVLFDQQSNTTQELLTVAIETQLEDILKKAIAKDRDIVKSFIKKEAIELAGEKHPVDLSQSIAKLHVLYSALSVSRSYNLDMAPKLLSCQGELIETLIHSGVGRYLEFKSVDDIFVFDDKTKGLEKVPSSKEDVFTNKAISLIDKRKLMKFLMYAVHYEDDETLLQESKEIPYVQFLEKNFKITGKLQTAIIYAIALSDINTLAKDGLDRTKSFMTSIGRFGRGGYLCPLYGGGSEIAQAFCRVCAVYGGIYILNHPVEKFCTEKGTGECIGVVTVDGQTFHSKTMIAGVDYLSPRWLPPASSLETWVARAILVTESPLNIKSTEETNAGLGYSLFPTNSEAGNTYAPIFMLHQNQETMTCPNNQYVTYLWTNCGKQHTSNNSLQKAISILLERSSESEEISFVKPLFAVYYHQRVRSIHTEGWNLPTNVIGCSTPNGSLDFEDAATEAHAIFRRCTPEGTEFLPPNEQDVETED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NX67</accession>
    <name>A0A167NX67_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lambda repressor-like HTH type 3 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_108945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MBF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294846.1">
        <property type="nucleotide sequence ID" value="XM_018428079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NX67"/>
    <dbReference type="STRING" id="763407.A0A167NX67"/>
    <dbReference type="GeneID" id="28988985"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_108945"/>
    <dbReference type="InParanoid" id="A0A167NX67"/>
    <dbReference type="OrthoDB" id="10019422at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008824">
        <property type="term" value="F:cyanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1160.10">
        <property type="entry name" value="Cyanate lyase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008076">
        <property type="entry name" value="Cyanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003712">
        <property type="entry name" value="Cyanate_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036581">
        <property type="entry name" value="Cyanate_lyase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186:SF2">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02560">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01693">
        <property type="entry name" value="CYANASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55234">
        <property type="entry name" value="Cyanase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD76806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="96" mass="11051" checksum="0DE3234127EC6D5A" modified="2016-07-06" version="1" fragment="single">SFEDIGKRIGHDEVYVAAMFYGQTKPSQEELEKLSSVLNIPTSHLKEELGDQFFPDRGGLVDLPPSDPTLYRLLEIIKVYGYPLKAIIHEKVWRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P2G6</accession>
    <name>A0A167P2G6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_180336</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the WD repeat coronin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295161.1">
        <property type="nucleotide sequence ID" value="XM_018438298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P2G6"/>
    <dbReference type="STRING" id="763407.A0A167P2G6"/>
    <dbReference type="GeneID" id="28999204"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_180336"/>
    <dbReference type="InParanoid" id="A0A167P2G6"/>
    <dbReference type="OrthoDB" id="347435at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000076">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000774">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF20">
        <property type="entry name" value="CORONIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="10">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="78"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1899" evidence="10">
        <location>
            <begin position="493"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="664"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="394"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="885"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="430"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="452"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="903"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="946"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD77121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="957" mass="104847" checksum="10742B0A416D7798" modified="2016-07-06" version="1">MSKRFQHLNKYRNAVGKVANKEAWYADLTLGSSPSDHCNLIQASRNWIAVKWTGNGGSMGLLPIDQPGKGCSSKAHVFHAHGAAVSDWSFSDFDDNLLATGAEDGLVKVWKISQEDETPVCLTSLTTPSRRVDLVRFHPTADQIVTTLGNDGKKVCIWDIEKSSCAFEVGTTTTDPFHSFSWKGDGSLFGTSSKGAVDVWDPRAQDKAVMSGSGHEGIKGSRVVWLGDSNAIFTVGMNKLRNRQYALWDVRSMSSPLKMTMFDSSTGIVIPLYDEDTETMYMMSRGDTTIRSLQLSDVQTTPTIAENMACGTNTSIYGAALLPKQSLNVMHAEVARVLAVTENAVLPISFEIPRKQYLDFHAELFPDTKGNVPGLSGSQWISGKNAQVAKVSLDPSNQAVNKTAESIKPSSPRETTPQQVLRNIDEPSVSKPSSQSPTKQNSSNTVDKIDKSVNNNNNNKKNSTDSTSDVAIPKASTSQQEEPVKPKAVPKYGSNHASAYKYISGKAYHPSTHFEDLRGLSVDKSGEVDLIKTNGKLIAVPIAGPGGRVGIISVNKPGRLPTHVPCVLCGSEVTNFQFNPFNDHVLATVSEDNKIRVWTIPEGGLEEDLGEPTAVIGTNAMDKIALLEYHPNAENILMTVSSDISKPTIRIWDLVEQKEKIVLTGMHPDIIFAAAWSPDGSRIATVARDKKIRVLDARTGKVLAEGPAHDNARPSRLVWLGASRIASVGFGRGSMREVLLFNTDDLTRPVKKNNIDVSPSVMGVHYDPDCRVLYVAGKGDRTIHTFELEDDDTLKALAKIESGTLQQGFAFFPKSSCNVRETEIGKFYRLTPNSIELVGVRIPRARPEFFQDDIFVETLDFGHPAQDSASWFSGENKGLKRISLKPDDMTPLSLAPPPPQQAKAKEKFEMGKKAVTEDQRRQELMDRMFSSAKEVVATEEKPVDPNDQEVADDEWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PBU0</accession>
    <name>A0A167PBU0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_185572</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295656.1">
        <property type="nucleotide sequence ID" value="XM_018439095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PBU0"/>
    <dbReference type="STRING" id="763407.A0A167PBU0"/>
    <dbReference type="GeneID" id="29000001"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_185572"/>
    <dbReference type="InParanoid" id="A0A167PBU0"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="209"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="3">
        <location>
            <begin position="829"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="765"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD77616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="885" mass="97263" checksum="016B3A3F0D59D4CC" modified="2016-07-06" version="1">MFHTPLKTLKQSLHTVLNQSQEYLADVSLVYPTQKIWAHRALLVTRVPNEFRIRYMPELQAESTSLTSLATIVPQELMMYLLRFCLDSLSIHDSRSSDEIRKQITDLEETLSMRLLPECETGKTDDEQWINDLTRMRADQVHSDVMINIFKAPVEIKKEPQSNQTPSQPSPAGLRIMSKSGGVPSILTSFSKTTDHQPVQTSPPVTITFPAHRFMLAAQSPYFRTMFCTEFKEAANATIHLPADLFSAAILDLILHYLYTDTLLIPPMPANTQSSNAVQQRLTIKKHSLRILQKVYRAADYLGHSDTICVAVLCELGNICHDFKCSCSDCAVLLPSMLSFSSQHAGLVVSEMRRKLITFYSDPVHSLSLWSQKPFAILIQSTLPTTPDGPKPTTQNATLIDDIVQQTFANITRHNAIHVLHSLHLCLSHIRSSDLSTTWSAPTLDILHVFLDHTVQMVSSNFDFYCVEYPILLSCVDGIGAGFSVDFLGFVLKHVLEEGIEDNNATVLYQGIVRDLVGRQEMVKNVAVDSVLLDARQSCASYIRRRSAAIKAIDGFNSLDKDVLRQLSDDIGIPVRTLTKPVESDFSAIFGFHPKAKAAFRSRTAESDEKLKTVCATASGGGNGGSGGTIDSRSSGRRLSFSGLMTHRYSVPTKTPAPAEDASASAIRPVPRARSHSSDAVPIQLGITSASAVSTSSASSVVSVGTDEKPAPRRRFHPPVSQGSSSSLTDVLLPIDSVASVVAVKGETPRPRKLKFELPATPLRTKLTPRKQISAQKRAQSPRRSRWGLGGSTTSDNSDEDESATIVIGTKIELLRRPLPTLGTIKYIGNVEFGKGTWVGVELESRVGNSDGAVDGKRYFQTDAQRGVFIKPDDFKVVHLPTSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PBZ1</accession>
    <name>A0A167PBZ1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_164529</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295668.1">
        <property type="nucleotide sequence ID" value="XM_018435026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PBZ1"/>
    <dbReference type="FunCoup" id="A0A167PBZ1">
        <property type="interactions" value="280"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167PBZ1"/>
    <dbReference type="GeneID" id="28995932"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164529"/>
    <dbReference type="InParanoid" id="A0A167PBZ1"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007891078" evidence="7">
        <location>
            <begin position="24"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD77628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="371" mass="40130" checksum="4AF8AE46D92F8063" modified="2016-07-06" version="1">MQSTKSSCLLALLFLALINLAQAQQLTAVVCNSLPTETYNLPLRIGSIFLILVTSGLGVFTPIVLFRVLPYKAGGFREHFLNIGKFFGTGVISGTAFIHMLPEAFGHFSSPCLSAGWKTYPGYAGVFCMVASFGLQLIELCAISNMEAMAKRRALAAQTEEEQAGIDERTDTKTVSAIKKEDASPHEHHHDGFSTDGHIHSAGFLENDEKMMRNMGTFILELGILVHSIIIGITVGTTGNHGFITLLIALVFHQFFEGVALGTRINELEFKGWIKPTIMGAFFLIITPFGMAIGVGVHSAFPANSSSFILAQAILDSLSAGILLYSAFISLMSLEINQNVAFRRSTTMNKVISFGSMYAGAALMSVLGTWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PQ02</accession>
    <name>A0A167PQ02_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_79591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296368.1">
        <property type="nucleotide sequence ID" value="XM_018443478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PQ02"/>
    <dbReference type="GeneID" id="29004383"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_79591"/>
    <dbReference type="InParanoid" id="A0A167PQ02"/>
    <dbReference type="OrthoDB" id="10540235at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="157" mass="16826" checksum="666706D5A36BA519" modified="2016-07-06" version="1">MQIFSTQKSTFSNVRVSNKAQPQPQPQAQTETEKPCAAKPSRVSAVTTSLAARIRGCSLVKKTLGRKKKTSSITPSLASSSSTLSYESFVSGPYLSKPSSLSRTGSSKSMELEALIFDHPTVTVRICPTSHPGEYTSCETIVQCPNCLDPKLIGGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PRY8</accession>
    <name>A0A167PRY8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_157550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296467.1">
        <property type="nucleotide sequence ID" value="XM_018433635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PRY8"/>
    <dbReference type="GeneID" id="28994541"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157550"/>
    <dbReference type="InParanoid" id="A0A167PRY8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="70" mass="7838" checksum="782F6BAEBBAC203F" modified="2016-07-06" version="1">MAIVESICTKEKLPFHVRLSNDKGALHTRNESQFIGGASFCLQIKGFYPLYTLGIIHGDYNGSKNKTQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PSM9</accession>
    <name>A0A167PSM9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan 1,4-alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_130696</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal (1-&gt;4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296508.1">
        <property type="nucleotide sequence ID" value="XM_018429381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PSM9"/>
    <dbReference type="FunCoup" id="A0A167PSM9">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167PSM9"/>
    <dbReference type="GeneID" id="28990287"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_130696"/>
    <dbReference type="InParanoid" id="A0A167PSM9"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000165">
        <property type="entry name" value="Glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046966">
        <property type="entry name" value="Glucoamylase_active_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF9">
        <property type="entry name" value="GLUCOAMYLASE, INTRACELLULAR SPORULATION-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00736">
        <property type="entry name" value="GLHYDRLASE15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00820">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007891285" description="glucan 1,4-alpha-glucosidase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="GH15-like" evidence="11">
        <location>
            <begin position="51"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD78468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="479" mass="53142" checksum="5B259C0A38E1C175" modified="2016-07-06" version="1">MHISRSLVFLSLCMSSVQSAIWQGWSKGRSAGVPPGNTALDDWVEKQEAISLKVILSNINPPGTRRGFFAASLSTSDPDYFYTWTRDAAKVAGVLVHAYDTSRRTDLHDVLIDYVEFQIGTQQTTTLCQCLGEPKFNPDGTGFSGEWGRPQNDGPAVRASTFLLLSQALSQKKYVTNILRPAVYRDLDYIVDNWATPSFDLWEEVLGVHFYTLMVMRRALLQGVAFSRSYEDAIHAANYQGTIGSIEERLESFWSPSRNYILATQDRVRGYEKPSGLDIAIILAANQLSGSIGGSSSSIKDGFFTPDSDKVLATAAALEYSFGTIYPLNQDLPSHLGIAIGRYPEDVYDGHRSSQGNPWFITTSAFTELYYNIILAFKARPTDITVNHINRPFFVKFDSQAVPGKIYVKASDEYNLLLADIAASADRFLATVKYHEQANGSLSEQFNRWTGFQQGARDLTWSHAALISATRARAGRPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PZQ4</accession>
    <name>A0A167PZQ4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_140882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296868.1">
        <property type="nucleotide sequence ID" value="XM_018430472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PZQ4"/>
    <dbReference type="GeneID" id="28991378"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_140882"/>
    <dbReference type="InParanoid" id="A0A167PZQ4"/>
    <dbReference type="OrthoDB" id="2289822at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="174" mass="19846" checksum="EA611D2A3C46921F" modified="2016-07-06" version="1">MGPLFFTFDKMHGLCHGIGKQKLAWQWQQQEKQFQQHFIALEEMYPSTVKLQSWNIYLKDLHQKDKIEITVFTINQNLLQHYPNIIGAFGSSRAYSTRSVERAIGKYSCTIKSNLAIGMNAGNIIVWLARIRQLLTDSEGGKQRGVVLQYEDMSAGWPITSKGECADADSNIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q5V6</accession>
    <name>A0A167Q5V6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHYBLDRAFT_14608</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297159.1">
        <property type="nucleotide sequence ID" value="XM_018431594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q5V6"/>
    <dbReference type="FunCoup" id="A0A167Q5V6">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167Q5V6"/>
    <dbReference type="GeneID" id="28992500"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_14608"/>
    <dbReference type="InParanoid" id="A0A167Q5V6"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000768">
        <property type="entry name" value="Probable mitochondrial chaperone bcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="15">
        <location>
            <begin position="58"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="259"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAD79119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="50130" checksum="040BDDFB4F7A3149" modified="2016-07-06" version="1">MPPLPLASLGLSEQTPLSPNDSNATSNATLNPIPDSPQTGIFANITSNPLFSAGFGLLGVGAGLSLLKKGTNAAASYTRRRLLVTLEIPSKDKSYAWFLQWMAQQAPKRQVQHLAVETSFKQHDNGSVTTKFGLVPGPGNHYFKWKGIWMKVERQRDGKMMDLSTGSPWETITVTTLSRDRGVFTHLLEEAQSMALKKQEGKTVIYTSYGPEWRPFGMPRRRRLLDSVILDNGITERIVKDVRAFIGSGKWYNERGIPYRRGYLLHGPPGSGKSSFIQALAGELEYNICILNLSERGLTDDRLNHLLSNVPERSIMLLEDIDAAFTKRSQSDNQGYQSMITFSGLLNALDGVASAEERIIFLTTNHLDKLDPALIRPGRVDLKEYLGNATPHQLRGMFLRFYGDRPDLADAFVARLDGKTVSTASLQGHFVYYKDDPLEAIEKADELLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q6K8</accession>
    <name>A0A167Q6K8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_139196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297199.1">
        <property type="nucleotide sequence ID" value="XM_018430177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q6K8"/>
    <dbReference type="STRING" id="763407.A0A167Q6K8"/>
    <dbReference type="GeneID" id="28991083"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139196"/>
    <dbReference type="InParanoid" id="A0A167Q6K8"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10229">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD79159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="579" mass="64670" checksum="D5F0A41220164329" modified="2016-07-06" version="1">MGSFATLAQQRLSHLPQPCFNSLFFTSTVIPVHTLLRCLSNTVAADFGTAYSGCSYLFGDNIKEISDITVWPKSDGFYYPKVPTAIYYESYTSKPIAWGHEAILKANMHNSTGHLITGFKLLLDTNNESTNILPHGLTAVQVISDYLREFHAYVHKQLKRELCTLYGTSKFRYCLTVPAIWDDKAKATMREAAILAGIVDRSDHPGRLMLTSEPEAAALYCEKICKHFNLTHGKRFMVCDAGGGTVDLIVFQIEEYAGIKSLREITKGSGGPCGSTFLDNRMRDILKRRFGSHADDNKRTIELIIKEFVSSKKPEFENEDVYFSVPAILNMGGHNMSRVGIHEGYLQVTAKQLREEVFDPVVDQVLSLISGQINQSQTKIDAIILVGGFGQSNYLSNRITDLFKSTVGSIYIPNRGEMAVTRGAVIFGVDPSRISHRILRRTYGLQTNTIFNYVLDADKRCYLVNGQVVCQDYFSVFVSKGESIDTNQCFTKQFCIYYPGILNLDMFAYDCSQETPRHVTSPGVCPVAKFAVEIPTLPNVKKGDKIGCTAKMYFGKTEIILEVVILGYAYVFTSAFDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QBB0</accession>
    <name>A0A167QBB0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_162487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297454.1">
        <property type="nucleotide sequence ID" value="XM_018434635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QBB0"/>
    <dbReference type="STRING" id="763407.A0A167QBB0"/>
    <dbReference type="GeneID" id="28995541"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162487"/>
    <dbReference type="InParanoid" id="A0A167QBB0"/>
    <dbReference type="OrthoDB" id="10044938at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="46424" checksum="5132B02932BB68BE" modified="2016-07-06" version="1">MYFGLNPSQLESTTHDVANLFRRTRFTSRFGLTGLSTTMMDNFQNNGSDTKVSEQTHNDTASSSVVDDFLSALFASKPAGINANQEASSGEQKSREFAPPVDMGAQQREPNIKPTPVAKQAGLKRDRLADEFEEYSILSKRQSANPSQTKQRTTSEKTRGHKPARGNRFQPNKRGAHQAQYQARQPPNMSHEGQPHNFDRQLSPVKRMDWEDPANSQAEISFNSQSNRGNYSQPARGGSTQSHRRIGTSNFQQGRPGPSSLPSQERSPVSVAGVPTYPSEGGIDRKTLTPETRMLIRRLPAHIKHREIVNHFSKYGEVLEFVPKKLHGFIQFSNPHSCAAAVVYRYMVIHMNLPMSEIHCYCHVVPSILLFFLLLLESNVSICVLYLEWPNWKIIKWSMSDPKDMNLLYCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QGL6</accession>
    <name>A0A167QGL6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_58709</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297701.1">
        <property type="nucleotide sequence ID" value="XM_018440373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QGL6"/>
    <dbReference type="FunCoup" id="A0A167QGL6">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QGL6"/>
    <dbReference type="GeneID" id="29001279"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_58709"/>
    <dbReference type="InParanoid" id="A0A167QGL6"/>
    <dbReference type="OrthoDB" id="5065855at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044613">
        <property type="entry name" value="Nep1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468:SF1">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="12"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD79661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="219" mass="25090" checksum="4758A94CFEF9CF61" modified="2016-07-06" version="1">MTCNTLLHFHDVIIREDDFCTLDEHNWLNDTILEFHMEYLERTFVTSETSIQLLRPAIVQLITHTHDPRQIISALPPRLNEQNAIFIPVNDGRPSAANSGSHWSLLVFLRPSCAFYYYDSMRYSNIQEARHTARQMALLLGLTKKPEFIPTSTPQQNNGADCGVYVIGITDSLVNRFMELKGKPIEADKLMMLPKSHVVEPTKIRNKLKCLIRSLGHTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QPT3</accession>
    <name>A0A167QPT3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_163081</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298071.1">
        <property type="nucleotide sequence ID" value="XM_018434728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QPT3"/>
    <dbReference type="STRING" id="763407.A0A167QPT3"/>
    <dbReference type="GeneID" id="28995634"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_163081"/>
    <dbReference type="InParanoid" id="A0A167QPT3"/>
    <dbReference type="OrthoDB" id="6409159at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007891625" description="Phosphatidylglycerol/phosphatidylinositol transfer protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="4">
        <location>
            <begin position="30"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD80031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="163" mass="17821" checksum="602B7B6064E506DC" modified="2016-07-06" version="1">MKFSSYLFLATALSLICGSNGQGPNGELQLTPCQESKGKIMVNRLTFDPNPPTIGKPVLLNFNGTFAEDFPLGMKVNLEFSKDGQVLFRQEKDFCQMVESLSLLKSSILCPLVTGTHNILAKMNVPGFIPSSLYGVNVKITKPDNDEVICLEGTTHLQQPLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QRR6</accession>
    <name>A0A167QRR6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_163197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298198.1">
        <property type="nucleotide sequence ID" value="XM_018434752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QRR6"/>
    <dbReference type="GeneID" id="28995658"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_163197"/>
    <dbReference type="InParanoid" id="A0A167QRR6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="143" mass="15679" checksum="B3669B05D3566267" modified="2016-07-06" version="1">MHPHRKATLIARLPMSLKGNVSFDVNPTKGDLNSTPIIDSDSKLIVHLLKPSQQNTNTPSSKVDNPTCHTLVQILSASESTKTCNMAPRCVSLGESTIQKTRFKPKKDVRFVDKSNSTSPRVLRSRTKAIAIARAMAVSKDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QTE0</accession>
    <name>A0A167QTE0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_163273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298291.1">
        <property type="nucleotide sequence ID" value="XM_018434768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QTE0"/>
    <dbReference type="GeneID" id="28995674"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_163273"/>
    <dbReference type="InParanoid" id="A0A167QTE0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="221" mass="25875" checksum="143068A4D02E53F5" modified="2016-07-06" version="1">MHLHMHLHESMLDFGPVYAFWLCSFERYNGKLKNIKMNCRNGLEVTFMRVFLEKAFISTFLHAYSTNLLLPMIQFLESVAQVMLPLIMMKNAHYQWLFEFDVKTYQSTSVSFYVVGRIPIGEDVFVNNWIQKVKKISLLGQEYCSGEKKKHGSFFPAYQSSHHQLLVEQGLELWEKGYMEESSSCIVSVHRLHSCFALATYKMQSEMQKRLVIPLPRKVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R149</accession>
    <name>A0A167R149_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methylosome subunit pICln</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_184374</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298649.1">
        <property type="nucleotide sequence ID" value="XM_018438925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R149"/>
    <dbReference type="FunCoup" id="A0A167R149">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167R149"/>
    <dbReference type="GeneID" id="28999831"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_184374"/>
    <dbReference type="InParanoid" id="A0A167R149"/>
    <dbReference type="OrthoDB" id="19714at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039924">
        <property type="entry name" value="ICln/Lot5/Saf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399">
        <property type="entry name" value="CHLORIDE CONDUCTANCE REGULATORY PROTEIN ICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399:SF0">
        <property type="entry name" value="METHYLOSOME SUBUNIT PICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03517">
        <property type="entry name" value="Voldacs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD80609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22667" checksum="650E8BB38BAA3CEC" modified="2016-07-06" version="1">MTVTLLSSPPDLTDLVVRRTEKKIGLLVSPPLAGMSGPIKGEMFVCESQLYFYSEEQHSGISVEYPDIIIHAISRRDGLPSIYCQLDSGLFFPNQDLPEDEQELEETVTELKFIPEDSESLESIYEAMSYCAGLHPDKEFMDDEEEEDDDFFYAQPSDDAELNEVQQAALRHLESVFEPIPNHTHQNGAKEGQFDNPMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R707</accession>
    <name>A0A167R707_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PHYBLDRAFT_74571</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299039.1">
        <property type="nucleotide sequence ID" value="XM_018443024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R707"/>
    <dbReference type="FunCoup" id="A0A167R707">
        <property type="interactions" value="362"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167R707"/>
    <dbReference type="GeneID" id="29003930"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_74571"/>
    <dbReference type="InParanoid" id="A0A167R707"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000016">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="18">
        <location>
            <begin position="30"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="199"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="473"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="20">
        <location>
            <begin position="579"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="15">
        <location>
            <begin position="685"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="1050"/>
            <end position="1147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OAD80999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1158" mass="130208" checksum="8980E773F135A198" modified="2016-07-06" version="1">MAASFNTLERERLFRNPSEDSYGVPILQEVVAPHLDSFNSITKFGDSEEGLLDYAVKDIGKMSVFDNSQNDTNVTESGQILGNKLTYWIEDPKIHKPMVNENDMLSKRRTVLPTESRERLVTYRGKLSVKLCWRVNDGPVSSESFGLGQVPIMVRSNRCNLYKMYSKQLVESMEESEEMGGYFVVNGIEKLIRLLIVPRRNHVTAIIRNSFQNRGSAYSSYGCAIRCARRDQTTQTNTVHYLNDGNSMLRFAWRKQEYMVPVVLILKALVDTSDKEIFDALCQGDIKNTFLTDRIELLLRSFKIYPLYTRNDCLKYLGEKFRIIMGLDDDLTDREVGEALLKKIVLVHLDNNRDKFNLLIFMIRKLYSLVSGECCQDNPDAPQHQEVLLGGHLFNMILKEKIGDWLTGIKQQIRNEIRMFPAKVDFFNNKYISTACRKTPSDVGSKLSYFMATGNLVSKTGLDLQQATGYTLVAEKLNFYRYISHFRCIHRGAFFAELKTTTVRKLLPEGWGFLCPVHTPDGSPCGLLNHLAHKCKVVNEPLSVDKLPPLLATLGVSQAVLHSINRPGDVAVMLDGCIIGWCTPKSAEKIATRLKVLRVNGEKGVPLDIEIASVPVSYGGEYPGLYIFSTPARMMRPVKFLANGKTDMIGTFEQVYMDIACMDDEVVPNVTAYQEFAPTNIFSIIANMTPFSDFNQSPRNMYQCQMGKQTMGTPSAVINRRTDNKLYRIQTGQTPIVRPALHNEYGFDNFPNGANAIVAVISYTGYDMEDAMILNKSAHERGFGYGTVYKSEIIDLSEYRTHGEPISYHFGLDPTKRKKFMGKIGDDGLPHIGAHLEADDPLCSYIDESTGRSVIKKWKGPEDAYVDEVRLLGDDSGTSPLQKIHIKLRITRSPVIGDKFSSRHGQKGVCSQKWPAVDMPFTESGMQPDIIINPHAFPSRMTIGMFVESMAAKAGALHGIAQDSTPFKFNEKYTAADYFGEQLIAAGYNYHGNEAMYSGITGEELKMDIYIGVVYYQRLRHMVNDKFQVRTTGPVHNLTMQPVKGRKRAGGIRFGEMERDSLLAHGTSFLLQDRLMNCSDYSRAHVCRLCGSIVSPISTKVASSLSSKQHYECRSCGTSKGIDLVAIPYVFRYLTTELMSMGIRLTLGIAPGAEDYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N7J4</accession>
    <name>A0A162N7J4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_73496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD71858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289898.1">
        <property type="nucleotide sequence ID" value="XM_018442867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N7J4"/>
    <dbReference type="GeneID" id="29003773"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73496"/>
    <dbReference type="InParanoid" id="A0A162N7J4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="110" mass="12716" checksum="803B9D01378ED73C" modified="2016-07-06" version="1">MTQKTLLGMTKRNALSLSLLSVHFVKEADFVFLLRLEWFIFMHVYAFGIVCNQKNPGYQINDRGFTDTGARHLCNIYHVTFTMYHLSLPVNFLKTNYKLGVAYAIVTLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N9W2</accession>
    <name>A0A162N9W2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_174590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441025">
        <property type="protein sequence ID" value="OAD67204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285244.1">
        <property type="nucleotide sequence ID" value="XM_018437288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N9W2"/>
    <dbReference type="GeneID" id="28998194"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174590"/>
    <dbReference type="InParanoid" id="A0A162N9W2"/>
    <dbReference type="OrthoDB" id="10433047at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="6"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="692" mass="81317" checksum="9A6FC6CA9E87F8D4" modified="2016-07-06" version="1">MTHEFPAELFFIIASHLTRSDYINCSKVCKSWRKPFYQLIWQTVVINHRRKAIYTQKVSNGINGLMYIKDTIPIYEVIEMSSIMLPNYRTNGAFTRKLKLGPLILASNAEITEIQKYFVNVNILFLYPLSVSPSVFMKKVYWTAWRNLSYLNTDIPYIYGTRKAQTILNIAFCIPTLNVLVIRNIDYETSDYFSVDDLEKLHHLLPNLTALRIKFSIAPVTVEEFERIACPSPAKMMVELDICYELTDFSLLYYCALKYPKLEIFSYKALSFRIRPLPTLFENIEGPFERPVRDLMNISVQYQGHILNKLRRLPPFFQNLKSIVLKDRPTSQWQSHMIWEFIMKFHVRITKAEYRVKGLRFKTSRGNPSMPMEMCLNACSDSVQRLCLTCCFIPYGPSIQIRRFDHFPCLVSLIIKLNYRVEIEVDYILHGCPVLELLLVDGDVLIISTENYNNIEHNLEEQKDISLLNERIYPRSHGLKHLLLGRLSIMAYILYYISCTCRNLETLEFHWVMIYGLMSQTKELEINMPYTSLKKLVIDYVNFERMHKGYRKQSYSSPHKINYFMIDTIDNRGPDSNGKKQRYERQKPVSVTGFNSSSWIYRPVFFETYPSGGRMWKVCLFYVLIESINFPQETANTRADDARPSLEIRHTIGFSENNHTNTLLSDKRYRQYCASFLFKVVEEYCVNMPVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NBM0</accession>
    <name>A0A162NBM0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_118100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285714.1">
        <property type="nucleotide sequence ID" value="XM_018428618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NBM0"/>
    <dbReference type="STRING" id="763407.A0A162NBM0"/>
    <dbReference type="GeneID" id="28989524"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_118100"/>
    <dbReference type="InParanoid" id="A0A162NBM0"/>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000002">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF3">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="6">
        <location>
            <begin position="33"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD67674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="382" mass="43033" checksum="90AF2E61FB43DCB3" modified="2016-07-06" version="1">MDRATSNAGRSRVITVRRNFVLEDGLRGLSNLSPTAWKGTIRVSFVNELGIEEAGIDQGGPFKDFISLLVAEVFKPSCELFAATPKTNLFYPAASSHIIGASHVAYFELIGKIIGKAVYEGILIDAQFASFLLSKLLGRNVFLEELRELDEDIWRNLTFVKHQDNIEDLGLTFATDEQINGKVVTHELKFLGSQTAVTDSNKVEYVYLMADYKLNQQAKEQTKAFINGFRSVIFDGWIKVFSPPELQRVISGEDTDFDVHDLRRHTDYQNGYFDQHPVIKLMWQIVDGLTSQEKRAFLKFVTGCPKPPLGGFDYLQPPFTIRMVSPDKDQQSMEGLGIVKSFFKINGLQNKGGRLPTSSTCFNLLKLPGKKIKHLYHIEPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NCL9</accession>
    <name>A0A162NCL9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_169361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD73108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291148.1">
        <property type="nucleotide sequence ID" value="XM_018436062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NCL9"/>
    <dbReference type="STRING" id="763407.A0A162NCL9"/>
    <dbReference type="GeneID" id="28996968"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169361"/>
    <dbReference type="InParanoid" id="A0A162NCL9"/>
    <dbReference type="OrthoDB" id="3248986at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD73108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="717" mass="82353" checksum="60F98A64D3BF9776" modified="2016-07-06" version="1">MSNNQKKDSYVICKCPDCTKLDSCGKKQKRQNAQRHYEKHIVPVAKDDAMDVPEEHFDDMEVDSIDSDNDNDYDYENEGEGEYEDENEEQNIEFDQEVDLPLSQEESIFTAEDTITGAFVVDGDEIKEGDTGFDFEQEENFDETSGTSIVESVRPSSFDNMPLNIRFVAVFIVIFHLIFLVESGGSILIEFCNTLLSLCDMSGALPLTINSLKHKTGFNMATDGMTVYIACLQCYSIYPPETSQRVCTFKKFSQSAICNNNLFKVSTGNCSLPAMVYPFNSLKYALQQKFSKPDFVSKINLWRKKENGTQWSELHRLSYFDPVRFTVIDPMHNLYLGTAKQMIQIWRKCNYINEKNQLTMQELANGIVVPCGYARITKKIADGFSFMKADEWKSWCVIYSPFVLKHVLPAKNLKNWILFVDACRLLTKPSINDKEIDEAHSKLQLFCTRFQTLYGKSAVTPNMHLHLHLGECVHDFGPIYAFWLFSFERYNGLLKNIETNQKGGFESTMMKRFLERTYIGSFIQSFVNHLPQFAIDFLHCISNSQDQLAALHPSSTASTFSLSDFVEYSLNPRHSALGCEPLPPSVFPIKLDQRITICKGHYECLLEFYRHAYGSHDLFGHYSNCESNQIFVNNRIEKMKRISLLGQEYSSGSYFRAYYLENNSEDKAAFPGRILYLFQHLITINETVITHTFAFVEWYSSYSSGSYQPMLNEGIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NDJ2</accession>
    <name>A0A162NDJ2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_136474</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the profilin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286534.1">
        <property type="nucleotide sequence ID" value="XM_018429790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NDJ2"/>
    <dbReference type="FunCoup" id="A0A162NDJ2">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NDJ2"/>
    <dbReference type="GeneID" id="28990696"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_136474"/>
    <dbReference type="InParanoid" id="A0A162NDJ2"/>
    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000001">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027310">
        <property type="entry name" value="Profilin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF0">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00392">
        <property type="entry name" value="PROFILIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01640">
        <property type="entry name" value="PROFILINPLNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00414">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD68494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="126" mass="13563" checksum="F72283F2A412D7A2" modified="2016-07-06" version="1">MSWQQYVDSNLVGTGKVTKGAIYGTNGSLWASSPGFQLAANEIQEIIAGFSNPEPIRASGIHVDGVKYFSLRADERSIYGKKNNNGVCIVKTTQAILIGLYDSNIQPGECTKIVEGLADYLISVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NDR6</accession>
    <name>A0A162NDR6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_145765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291408.1">
        <property type="nucleotide sequence ID" value="XM_018431531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NDR6"/>
    <dbReference type="STRING" id="763407.A0A162NDR6"/>
    <dbReference type="GeneID" id="28992437"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145765"/>
    <dbReference type="InParanoid" id="A0A162NDR6"/>
    <dbReference type="OrthoDB" id="435520at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF10">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="182"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD73368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="506" mass="56519" checksum="6DE80E7D26DEC719" modified="2016-07-06" version="1">MRNRENQRPEQCLDVDQSYERSIYASDLRSPPLSPTTITSSRSTPLPTGNGRLRKRPREYLGHLPDRSTSYGPGFSTPTSPTSPTSPTSPSYHAFQPAVSSPPLKPINHKEHVFSANKKPVLIPRFNSIDEPRMHQTFRYNAQPGNKLKSHNVGYADYGSSYSDYPVFVIGGHGCTRLVGVMFAELAQRYGIRMIWPERPGYGLSDECNLQHISALAWADVIIQLADYLGIKQFGIIGQSVGSVFALAIAHKYPSRVFGPVFLISPWVSTQAANTFKWARRLPAAIVTRTASLAMDVMWMFNKGLSVSRDTTPRSTNTTSANTSSNNSFDEGFCTGTEDSPRTSETDKRGYGSKKGIESPPQKTHQQKLTALEEDELLASLDECLEFTTDFPPHRPLRHVVRPKHVSLYLTMNKQRTAEPYNQGQLADVLVALEKYNQFGFNYSDIKTSVSAVWGDKDGLIPQRGIDVLANSLRDLHLKILEGEGHDLVWKEGVMEWAIRGISERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NEP1</accession>
    <name>A0A162NEP1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_71835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291658.1">
        <property type="nucleotide sequence ID" value="XM_018442549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NEP1"/>
    <dbReference type="GeneID" id="29003455"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71835"/>
    <dbReference type="InParanoid" id="A0A162NEP1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="135" mass="15433" checksum="BAAE0789AE849AAE" modified="2016-07-06" version="1">MFGYNSVKLRFKRHGNMATPESEISESSAGVKISSVFSLCQRNYLRMGNVQLSSSMNGNETPRNTIHRYNLFYLYLGCSNIHQNIIFFHSRKPFIIRFHTFTIGRASVAEAVQIDIKLSAHKPHLRLKEVKKNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NF62</accession>
    <name>A0A162NF62_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_172858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD69024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287064.1">
        <property type="nucleotide sequence ID" value="XM_018436885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NF62"/>
    <dbReference type="GeneID" id="28997791"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172858"/>
    <dbReference type="InParanoid" id="A0A162NF62"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="117" mass="13653" checksum="4C8D35F2E3F30261" modified="2016-07-06" version="1">MDSIKEKIRELQAETDKAIAKADDLESRARDLEYEIEIKELTIVSLERHLEKSNEDINEFSVFFTNQSACFDEYRADADEAARKITALQLELQDKEEKFIACRAELDKLTHRSDKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NIA7</accession>
    <name>A0A162NIA7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_171957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287974.1">
        <property type="nucleotide sequence ID" value="XM_018436698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NIA7"/>
    <dbReference type="GeneID" id="28997604"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171957"/>
    <dbReference type="InParanoid" id="A0A162NIA7"/>
    <dbReference type="OrthoDB" id="3248986at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="441" mass="50891" checksum="F54182080008384F" modified="2016-07-06" version="1">MFNSRYVVDKDAIILIPFFNIVSEHYEEHFRHPISIPALKNMAGFSDLASELHRLSYFEPVRSTIIDPMHNHFLGTAKRMVDKRILSKILTDADLVEMQNEANKLTLPRVYTTITSKIGKGFPFMKADGWKSWCLVYPPAALKKHLPDELYVNWIHFVDACQLLTKPSITKNEIENAHQSLKKFCIGCEDLYDSDVLSPNMHLHLHLKETIEDFGPVYGFWLFSFEQYNGLIKGFNTNRKNGFKKTYMDKFIENASKSDFHRTNLHTIANLHHLTIFNKLSDSITGIKNTSVLSPLSIFRLTSFVESGFNPNKQTLGNESLPQSAYPLNLKEPLTMKIGEYECLLKYYRIYAKRVIKNPNFVNDRIRKIQSINLFGQKYAGSEGSVTRGTHIMARFATKDGNPRGTYAGRINYLFFPRFIFTSHSHRFSQPLEPTRCICFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NII1</accession>
    <name>A0A162NII1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_149158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288034.1">
        <property type="nucleotide sequence ID" value="XM_018432227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NII1"/>
    <dbReference type="FunCoup" id="A0A162NII1">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NII1"/>
    <dbReference type="GeneID" id="28993133"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149158"/>
    <dbReference type="InParanoid" id="A0A162NII1"/>
    <dbReference type="OrthoDB" id="10050400at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040201">
        <property type="entry name" value="Mrg3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142:SF1">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="418" mass="47146" checksum="0ECF73DFB6967AC4" modified="2016-07-06" version="1">MATRLLRSISLIPKQSIISRAQVRAGSRLPIQSTHFVNFQKQTFATARPPSSTNGERTINIPRIPLLLIGIGFACLGVGLYEYFTSDIQKYPPPIRQALRKALYFSQDDRDTKLALQYFRQALELGIESPEMERDGAPLTGIMIQLGVLLETLGRLPEARQTLTLALRHLVGFENDRESVKDKRPDSDVFNVDLSSLPTQTQKKIVGIAQKLGDIAAKCRLDDEAEKWYTWSVEHLLRISSRPKSEYNDTEEVIFDKDHMPAWLTKAELGGALEALGTFYATHGNYVFAIQLYLQALNMAGLKTCHTSVLMNNLAEAYAAMGRFEEAKQWGQKGLDHAQNPNTRKLNDDGEECDATCGTLLYNMGMLFEQTGDKAKASQFYKHAGLHGRKFKLDECVQESDRALRRIEFEQRHPATFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NJW7</accession>
    <name>A0A162NJW7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_76262</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288394.1">
        <property type="nucleotide sequence ID" value="XM_018443136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NJW7"/>
    <dbReference type="STRING" id="763407.A0A162NJW7"/>
    <dbReference type="GeneID" id="29004042"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_76262"/>
    <dbReference type="InParanoid" id="A0A162NJW7"/>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000002">
        <property type="entry name" value="putative tyrosine-protein phosphatase auxilin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051982">
        <property type="entry name" value="CiliaryAsmbly_MitoImport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45984">
        <property type="entry name" value="RNA (RNA) POLYMERASE II ASSOCIATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45984:SF1">
        <property type="entry name" value="SPAG1 AXONEMAL DYNEIN ASSEMBLY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="236"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="211"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="287"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="440"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="703"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="646"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="287"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="446"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="724"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD70354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="850" mass="95384" checksum="61632AEFAB7B0818" modified="2016-07-06" version="1">MNDLVNLDWDEPQSSKTTTPRPKQDAFASLLQLNSRPAPEVVLSLAEQQRQQAQKQTLRSEHQSTSSPWLTPTQSAIASPTQQPLSPKQLVPSNSPTPSSSFDSLLDPFARSSKQKQDNTNTPLNTLRATSLKAATTEQTGQQWNFDLFDKDVLQKNISPSTSYVASDPFDMDFLASGSANGTIHLESSVELEDDENPLGILAKPAVQKRSVTPEQSLSLEPVSADNEAVSQYQDDQDEQDTQDELLAQLIDMGFGAGVSLEALRASGGNDLQGAIALLVTDAEVNRNQQRSTSRTNTRSSTPSYSDAEQARQKIFSDDNDVQKSPARRATREVKRQSQREANTQQQNQQQHNDAFQQHTERFVAQASEIGGFLFKNASMFVKTGREKITKAVDNWQEQQKVHSSTDTGGPVRPRWMTDVPEDQIERGFDEKPLEKFVDEADSDEETHPDPQSHAERERVEREKNWTRQQEIQRREDIERRKRAQQQQQKQQQQQKQKQKQTLVDDQNTYLSPSRRRPPPRAMSRPQEDSRPTTPKPAPTQPVKKVRTRPVVQATPQAVAKANQARQKGNELFKLGQFGDAAHAYSQAIDALPLGHDHLALLSNNRAAARLKIGEHKGCVEDCSLVIEMAQQMGDDPITESEGVAIRWKEQTIKALNRKAEAFENLEKYQDALKTYEDLTKLEGNGSLQTNQGMARCRKALAPVPQRQNLEKKRQPSPAPSRSVDVRESKAVADMRARAAQQEADDAERLEKTDQVNEKLLAWKSGKEQNLRALLATLDALLWPGAQWKGAQMSELINPKKCKMIYLRAISKVHPDKLPSTVTIEQRMLASAIFSTLNEAWDAFRQTNPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NLD3</accession>
    <name>A0A162NLD3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_143545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293328.1">
        <property type="nucleotide sequence ID" value="XM_018431010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NLD3"/>
    <dbReference type="GeneID" id="28991916"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143545"/>
    <dbReference type="InParanoid" id="A0A162NLD3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007837827" evidence="1">
        <location>
            <begin position="30"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="295" mass="32736" checksum="BBB427834FC3B193" modified="2016-07-06" version="1">MTKHIPTAPRRPNLFMNAVLNSTIAGVVALINTPTPEVAVVTSPEVQVAVTPMDHVLTLLAVNNVSMQSLQENAKGVTDAITHLKNGLDLSNKTNEFLKNSVLQLMTENAEIKKAMTSQNSMMPSAVPADSSSSMDDDLDHGTKHHPLISQLINSYIKKPNFVSTDLLKVAENNNRSAWSMTGTYGNKYNKTLALALFKYLGPQRCYTNVSKTEKIMTRNKAGRRRNRKKTTYTETTHEGMNRYDCGNSLSIDVMSDGESDGDNKVRAYRPSWRTNEIITIDELTVISLKRNSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PGG3</accession>
    <name>A0A162PGG3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_146767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290617.1">
        <property type="nucleotide sequence ID" value="XM_018431718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PGG3"/>
    <dbReference type="STRING" id="763407.A0A162PGG3"/>
    <dbReference type="GeneID" id="28992624"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146767"/>
    <dbReference type="InParanoid" id="A0A162PGG3"/>
    <dbReference type="OrthoDB" id="2596771at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="173" mass="19533" checksum="F892EC1A68A23897" modified="2016-07-06" version="1">MSNNNINNTIYDISTVQQVLINSPLEGIKMLPLNSTILVKASEWEKCLERINVLCSTKWNKKHKYSGKGLVFGETKKCHRAGQYITNRQLRLAQKDMKACSCTAALKIIQHLDNPNVVTFCQTRAHVNHVPGDWDEVRTLPLPSEAIKIIEDQLKSGSSCRSTRISVLRQIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PJ10</accession>
    <name>A0A162PJ10_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_65935</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291367.1">
        <property type="nucleotide sequence ID" value="XM_018441560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PJ10"/>
    <dbReference type="FunCoup" id="A0A162PJ10">
        <property type="interactions" value="634"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162PJ10"/>
    <dbReference type="GeneID" id="29002466"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65935"/>
    <dbReference type="InParanoid" id="A0A162PJ10"/>
    <dbReference type="OrthoDB" id="189968at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000509">
        <property type="entry name" value="U3 small nucleolar RNA-interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039241">
        <property type="entry name" value="Rrp9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="169"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="221"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="263"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="305"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="434"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD73327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="531" mass="58987" checksum="0A21778687A7F03B" modified="2016-07-06" version="1">MPDAFFSSSRKRKTTSTNNTTSTTKRGGKSAPPKRQRSQPSSNNNNTTGSGKKLLVNKNKNKKDSDDEDDNEPSNIDDMNLMASDEDSSEEEIEETAAEKRVRLAKAYLNKIQDSLEDDLDGFDAADLDRDLIADRLKKDADEIAGKLHRRVADLYDFEAIDDSSIKTCRGHQLAVTAVALSENGSIIYTGSKDGSIIKWDVKTMKKLHTFPGGRKGVKDFVGHTDHVLSLALSSDNQYLASGGKDKILNIWSVKDNQRISSFTHHKDAVSGLVFRKGSNQLYSASHDRTIKLWNIDERTYIETLFGHQDQITAIDTLGRERCMTTGGRDKTARLWKIVEESQLVYRGGVTTKITDGEEVRSFTEGSIDCLAQLDEDMFVTGGDSGTLSLWDINRKKPTFSFGAAHGLKVVKSESEGDIKTPYWITALASLRYSDLLVSGSWDGFVRIWKLSKDNKNLSQIGQIPVEGVVNSIQIKTVFPSNRTLLVIGVGQELRSGRWVRLKGVKNCTKVIELPTFKSKSKTETETETAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PS53</accession>
    <name>A0A162PS53_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromatin modification-related protein EAF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_143719</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MRG family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293517.1">
        <property type="nucleotide sequence ID" value="XM_018431051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PS53"/>
    <dbReference type="FunCoup" id="A0A162PS53">
        <property type="interactions" value="454"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162PS53"/>
    <dbReference type="GeneID" id="28991957"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143719"/>
    <dbReference type="InParanoid" id="A0A162PS53"/>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18983">
        <property type="entry name" value="CBD_MSL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038133">
        <property type="entry name" value="HAT_Nua4_EAF3/MRG15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="9">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="78"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD75477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="293" mass="34966" checksum="2A8E6B7E84AB93E6" modified="2016-07-06" version="1">MAKDEKKFRFDKDERVLCFHGPLIYEAKIIKREKRDDPEEPEGSHYLVHYKGWKQTWDEWVPEERVLKYSDANLQKQQQLKETHLKRKPSRASASTSTSNHLNDTTESRRKRNRDSSMDKTRTEDDIKRPEFKLPIPEILKGLLVDDWENVTKNKQLVHLPREPSVNQILEYYRQDARGRRIIDDETLNEFIQGIRLYFSKTLGSSLLYRLEKKQYEEVRKSYPDRNFCDIYGAEHLLRLFVEIPSLASQSNVDTDTLSQLRNSFTDLLRFLLDHEKEYFAGDYQSNAECRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PSJ5</accession>
    <name>A0A162PSJ5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_113773</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290546.1">
        <property type="nucleotide sequence ID" value="XM_018428355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PSJ5"/>
    <dbReference type="FunCoup" id="A0A162PSJ5">
        <property type="interactions" value="354"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162PSJ5"/>
    <dbReference type="GeneID" id="28989261"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_113773"/>
    <dbReference type="InParanoid" id="A0A162PSJ5"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD72506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="181" mass="21336" checksum="643B603F0A90585A" modified="2016-07-06" version="1">MPAISQQPQKDQSMALGKDREISTIPRAESSEKLWVYPSEQMFFNAMRRKNWNPEEKDMGVVVPMHNAVNEQAWSKILEWENMHKTQCNQPKLLKFQGRPKDITPKARIRSWFGYTLPFDRHDWTVDRCGTKVTYVIDFYTGKRDPRRPEAVSFYLDVRPAVSPSGVWDRLKWAWQKGSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PY64</accession>
    <name>A0A162PY64_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_143571</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293356.1">
        <property type="nucleotide sequence ID" value="XM_018431017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PY64"/>
    <dbReference type="STRING" id="763407.A0A162PY64"/>
    <dbReference type="GeneID" id="28991923"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143571"/>
    <dbReference type="InParanoid" id="A0A162PY64"/>
    <dbReference type="OrthoDB" id="2260257at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007838455" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="25"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD75316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="210" mass="20211" checksum="6F30DAE1973B08DD" modified="2016-07-06" version="1">MKIFSAILALAVAAVSADNIVSVTSPLTGTVYTAGKSAIISWVNPTVDQISQIVFSQGLSTALQPVSVIATNVDASSGTYTWEIPADTPAGTDYAFVFGTSPNQSYTGQFTVKSAAESSVAASAAAPAAESSSAAHGGHGAASSAAPSAAVSSSGSGYHGHGDASSSAAAAESSTSSDHHGGGGYSSAASNNVAAVGVVTLIGAAVAALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T461</accession>
    <name>A0A162T461_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_80493</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV441005">
        <property type="protein sequence ID" value="OAD66142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284182.1">
        <property type="nucleotide sequence ID" value="XM_018443586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T461"/>
    <dbReference type="STRING" id="763407.A0A162T461"/>
    <dbReference type="GeneID" id="29004491"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_80493"/>
    <dbReference type="InParanoid" id="A0A162T461"/>
    <dbReference type="OrthoDB" id="2690153at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="4"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD66142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="627" mass="69871" checksum="BF6DEC84064EF904" modified="2016-07-06" version="1">MITVDVLVCGAGPVGLFFGYLMAIKGHSVYVFDKIAEPSENSRALLITSRTLEMFSLVGLDAAVLKEARIVRGIQVFSGGERLGTAEASGDTTFPQQNILPQVRLERILETKLASQGYPVHWSTTLTAYSQTDSGIEATLSTQEEQEQNEGLVTVRASYMVGADGTHSAVRRLCASDWDFKGVAVDTRLALADVTLKGRHVDQEMMNRLSSFLDGEGAMIFLPFEPVNPNPDPDHHFRVIVSMGKYEKLENGQTDQVTHGIRARATDRDRKNKDALSLEQLQETMDRRLGNLDIHASNPAWLTFFAINERIVDDYRRKRVFLAGDAAHCHSPLGGQGMNIGLQDADNLAWKLSLVLNNYSNDPDFLLDSYSIERRAIAKSIIKSTSQGTSFVFRFIRNGLIRIAMSIPQIRNLGVQTVQQIKMSILDSPLHGLADPHLIKPGQFMKNTSALRRRTIEDRLVWASLHNILRKTKDSRFTVLWVSTCKGWQTPSSSGLTTKFLQSLKPYSRVVRPIVVTSAWHTRDSHPIVQSLGDPELAEAEWWVEGIWDEQCVTRRVGLDKAIIRFTGSTETAVETAVAMVVLRPDLFVAQSSLVQTEKDLEKAVGYLAHAFGTIVTHKHHSLNQSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TD43</accession>
    <name>A0A162TD43_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_70990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441005">
        <property type="protein sequence ID" value="OAD66173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284213.1">
        <property type="nucleotide sequence ID" value="XM_018442383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TD43"/>
    <dbReference type="GeneID" id="29003289"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70990"/>
    <dbReference type="InParanoid" id="A0A162TD43"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="155" mass="17509" checksum="5A3535F26C2BA06B" modified="2016-07-06" version="1">MLTIYLTTQARLKGLEATVTQLQAWADSSQETGNNIPLENICHLLAEEQEIGQVPNDQTLQDIGRPATAIQRAMAIYLTECDEAAACVMYRSASGIICSLLRADFKLFHDRGESVPLWSDLTKLQKKDLIKNFELHASFRNIYPNRFLKLLLNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TL49</accession>
    <name>A0A162TL49_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_79128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286003.1">
        <property type="nucleotide sequence ID" value="XM_018443433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TL49"/>
    <dbReference type="FunCoup" id="A0A162TL49">
        <property type="interactions" value="238"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TL49"/>
    <dbReference type="GeneID" id="29004338"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_79128"/>
    <dbReference type="InParanoid" id="A0A162TL49"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13214">
        <property type="entry name" value="PH-GRAM_WBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044852">
        <property type="entry name" value="WBP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF1">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="28175" checksum="37263508E7316212" modified="2016-07-06" version="1">MSLNWAMLGPNGQTPVLLPGEKVFTTQNAVKMVLDCNENGYPGNAGGYWEADGTVTLTNQRIVFAASSPSQTFQTLNVPVLMWKNWKLEQPWFGANYISGILLPVPGGGLSKNGKLSLTFREGGSIEFTTIYRSLLERIGETNQTPQHYEPLPAYEGPSGGASGHTNYPPPPMPVQEGSTSGGNQIVYPPPSPPAPAPFPSSTYMPTPQIQPQCTISPVNQRVYPPPPMPVPYEHPSLNPNPGLDQSLSDLPPSYDTISNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TSG1</accession>
    <name>A0A162TSG1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_149219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287473.1">
        <property type="nucleotide sequence ID" value="XM_018432235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TSG1"/>
    <dbReference type="GeneID" id="28993141"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149219"/>
    <dbReference type="InParanoid" id="A0A162TSG1"/>
    <dbReference type="OrthoDB" id="10510641at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="39068" checksum="ADB6A335D795164A" modified="2016-07-06" version="1">MPSNSSRKTDRKGKGKASASISTSANRVLAGRVGPREIAPINNNINGVKDDIAAVNSNMAAFKNRMGVVVDTSGKTHTAFADFATAYANNQTRMASLGPSLMPSYVPQISLSDAEVSVIISEIFMEKLWDWKFESDDPALVAENESKKKWNLNEKINHRDNVAVINYLKSYISAQTRLAGTHPRVISDKIKNRYKHSHRTFHESPEQKAKKNSKGRANSRTLQMSIRRKSTYMDNWVAIDAAMGYKTGNPVEKAYLKLFQKDAMSDGESDIEIVDNLPRRCLHVARPTWRSEEFNRLLTMVNNIDHTHHVLNAGVGTKPRMNRYPATLLPCSVPATLSQSLPRWAINDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TTE8</accession>
    <name>A0A162TTE8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Mediator of RNA polymerase II transcription subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_66118</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287703.1">
        <property type="nucleotide sequence ID" value="XM_018441589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TTE8"/>
    <dbReference type="STRING" id="763407.A0A162TTE8"/>
    <dbReference type="GeneID" id="29002495"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_66118"/>
    <dbReference type="InParanoid" id="A0A162TTE8"/>
    <dbReference type="OrthoDB" id="10253553at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009244">
        <property type="entry name" value="Mediatior_Med7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044888">
        <property type="entry name" value="Mediatior_Med7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428:SF11">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05983">
        <property type="entry name" value="Med7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD69663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="226" mass="25532" checksum="2F936E9F45741DED" modified="2016-07-06" version="1">MTEQQSTGSAWPDPPSFYKRYTAENVEKLKKARKTGIYPETPISLPPLPDFLLKSLEPPTPPTDSYKIFDQTWQVEDRLATLNELGVKQLFPEGQIDRIKELKKLNRTLIVQYLGLLDILVNNPDEARETLKLLMENQVAKKRQQAAELRRKSAETLQMLHDFGQEIGHSLTDHTGRGGEVFGKFEHIDHLGSNSEDVKMSETCIKNEGTSDALELNVTSAIDSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TW64</accession>
    <name>A0A162TW64_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_114281</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289502.1">
        <property type="nucleotide sequence ID" value="XM_018428383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TW64"/>
    <dbReference type="FunCoup" id="A0A162TW64">
        <property type="interactions" value="441"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TW64"/>
    <dbReference type="GeneID" id="28989289"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_114281"/>
    <dbReference type="InParanoid" id="A0A162TW64"/>
    <dbReference type="OrthoDB" id="409625at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01722">
        <property type="entry name" value="Sm_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000011">
        <property type="entry name" value="small nuclear ribonucleoprotein F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034100">
        <property type="entry name" value="Sm_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD71462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="83" mass="9350" checksum="46ED77349CF644F0" modified="2016-07-06" version="1" fragment="single">VPVNPKPFLNNLTGNTVIVKLKWGDEYKGYLISVDAYMNLQLANTEEFKDGVSVGVLGEVMIRCNNVLYIRGVDEDKQDVKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U8Z6</accession>
    <name>A0A162U8Z6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_177585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291383.1">
        <property type="nucleotide sequence ID" value="XM_018437903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U8Z6"/>
    <dbReference type="STRING" id="763407.A0A162U8Z6"/>
    <dbReference type="GeneID" id="28998809"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_177585"/>
    <dbReference type="InParanoid" id="A0A162U8Z6"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000003">
        <property type="entry name" value="Long-chain-fatty-acid--CoA ligase FadD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="32"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="5">
        <location>
            <begin position="443"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD73343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="544" mass="59556" checksum="24817AD006AA5ED4" modified="2016-07-06" version="1">MPINSRLPPIKVPKTGLVQYLFEGRKFNTPQNKILSIDVATKKTLTLHQIKRDVLRFAAGLQDDCDFKKDDVILIYAPNQYDYAIPLLGAIAAGGAASPANPNYNTGELVYQLEMTKAKILVAHSENIKTALEAAKVVGLPANRIFVFGDDTINGVLPYSALLGDRLAIPVDYTEKEAAESVAILCFSSGTSGKSKGVMTTHTNITSNMEQYYASEREEINPSIDRALGILPFFHIFGLTVVLFSCFSLGIPLFVMPRFDLIAFCETVQNENITMACLVPPIILLLAKHQIIDQYDLSTLRLIISGAAPLSAELSQAATARLKTTVVKQGYGLTETSPVSILERTSKAIAGSTGKIVSNMVAKIVDEDGKEVGPTERGELWLKGPNVMKGYLNNPEATADCIDSEGYFHTGDVVEMDSEGNVYIVDRIKELIKYKGFQVPPAELEAYLLTSPIVMDCAVIGVYDDEQATEIPRAYVVLKEGTAPSVETENIIMKHVADKVVAYKQLRSIVFIAEIPKSASGKILRRVLRDLANEEKKTFIKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UAU8</accession>
    <name>A0A162UAU8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_64677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291763.1">
        <property type="nucleotide sequence ID" value="XM_018441336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UAU8"/>
    <dbReference type="GeneID" id="29002242"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64677"/>
    <dbReference type="InParanoid" id="A0A162UAU8"/>
    <dbReference type="OrthoDB" id="2231428at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="608" mass="70713" checksum="C38CE77984D8CD13" modified="2016-07-06" version="1">MLASELPFEILSQIASFLSKPDQCNASSVCRAWKRPFNEEFWRWTDIGYEPGFDRSCCLLLDILGNGSNYGQMVRSLSLAEDIEIHCDILWQLQTYLTGLTYISLPEASLTTSCFHHLNRWLTWSTTLTRLRFCIHGMGVGVSDFLDLLEYLPRLQWLEYTPERATHSLFRLEDVETIHTHLKNLDTLILGTELSCLSPQNLELLSTVQPAVAMTFVKFSVNPVDLRWLYYWAIKYPRLRTLEWITRHDFDPVYMFRDETLLLFSQQDSPFEYLRNLRLLGGIYSRILDKTLIDLLCNFKIALKNIKYETQVGRNDAQPTLQLIEDIMRSSSNTIEDFSLSLQHPIANPRTVPMTFSVCPHLVNLKICGWTTHLGLDLLLDYCVAVKRLDITVDTLSIDSESSLAFFQSVHSMTYFRLIANSVHASVFNYLSKRCKNLQHMELLNVDIVGPQSVENGSMLIDMSFTHFKTLRLNCTNFHGHTIDLDTPNTLINILNVQGVSETRHNWYHIHSNPSNYKYTIGDRHRHLRFTRNLGQKHCKLASTYFNSRYRLMREEAIQRNGRIEFETKYVDKNNWKIDLLRGFTVLSCASIDQFVWECTVPTFPFRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UEY9</accession>
    <name>A0A162UEY9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_142752</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SHQ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293792.1">
        <property type="nucleotide sequence ID" value="XM_018430863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UEY9"/>
    <dbReference type="FunCoup" id="A0A162UEY9">
        <property type="interactions" value="699"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UEY9"/>
    <dbReference type="GeneID" id="28991769"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_142752"/>
    <dbReference type="InParanoid" id="A0A162UEY9"/>
    <dbReference type="OrthoDB" id="73639at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00298">
        <property type="entry name" value="ACD_sHsps_p23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039742">
        <property type="entry name" value="Shq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048696">
        <property type="entry name" value="SHQ1-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007009">
        <property type="entry name" value="Shq1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967:SF0">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04925">
        <property type="entry name" value="SHQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21413">
        <property type="entry name" value="SHQ1-like_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="234"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD75752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="497" mass="57792" checksum="679F94C5B679DAF5" modified="2016-07-06" version="1">MITPTFKVEQDDNSITIIINTPYVRAQDVDLHVSGTEFRFFLRPYFLRLYLPANVVEDDDSKAVYDPSLGQFTVKVSKENKGEHFPDLDLLTKLLARRGEAADVSVDQAQPKKPLIEVIGSQDNKEDVSMEESTDQIENEFQKAADFNWELPQELPADDLMIHSVYGFNNQYSGYFTHVQETMNEIIDIREPEKSTIESRRQDRLEQEELKFDEDYYAMDFVNDEEIQNAIKYKTIWSKELKRIQKQAKEEEQQKKQNEKKSLIQEITPDLTQSNVDIDMNGLSIGDQNESLIKFTPKEEALMRSLPNKEYLLSNEKVTYLGLVDLLFAYSYNHRVSEGDNTVESVWCVGKLSPTISCLEQFTTLKDTIIACCRRVLSYPLYRNLALCEKVLQDVYVLFRLGKRAILKALLDMKDLFDHHDVYYVYSKIWLDDYCVWIQHASDHVIRTLAHELHHFKVPKEELGWDLSELEEIAKQMNDLEAEQGMNGVEEQGMDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UFD1</accession>
    <name>A0A162UFD1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_124113</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292773.1">
        <property type="nucleotide sequence ID" value="XM_018428971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UFD1"/>
    <dbReference type="FunCoup" id="A0A162UFD1">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UFD1"/>
    <dbReference type="GeneID" id="28989877"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_124113"/>
    <dbReference type="InParanoid" id="A0A162UFD1"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF17">
        <property type="entry name" value="RHAMNOLIPIDS BIOSYNTHESIS 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD74733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="263" mass="27286" checksum="60FE0D097D1AB2AE" modified="2016-07-06" version="1">MNIEALFSVKGKVVLVTGGSRGIGEMIATGFVQGGARVYISSRSSKACDEVAAKLTALGPGECISLPGDLQNLADLKGLVAELTKRETHLDVLVNNAGATWGAPIDSYPDAAFQKIMNLNVTRIFTLTQACLPLLRANASADSPSSVINIGSINGESVPGMETYAYSSSKAAVHHLTRHLASTLGKEHILVNAVAPGSFPSKMMAATLRDFGDEIIAKVPVGRVGTPEDVAGTCIYLASRAGQYTCGSVIVVDGGALHSSSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UII8</accession>
    <name>A0A162UII8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_166719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293523.1">
        <property type="nucleotide sequence ID" value="XM_018435466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UII8"/>
    <dbReference type="GeneID" id="28996372"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166719"/>
    <dbReference type="InParanoid" id="A0A162UII8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="103" mass="12486" checksum="3334D256B40E811F" modified="2016-07-06" version="1">MRHIFQSTLSYSFLFYTRALELSAKLAPYHSDTVYLELKKFLRGRIEDLRLETKIRENLCRFCLLRKDFVSKFDEVPTLNYYCYLYYFGLGKLYDWGQIIDPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UJN5</accession>
    <name>A0A162UJN5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_63109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294722.1">
        <property type="nucleotide sequence ID" value="XM_018441073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UJN5"/>
    <dbReference type="GeneID" id="29001979"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63109"/>
    <dbReference type="InParanoid" id="A0A162UJN5"/>
    <dbReference type="OrthoDB" id="2286441at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="255" mass="29245" checksum="F7F5E9072C1D5519" modified="2016-07-06" version="1">MWRSWVDRINTVNKNPCSDDHPAMSPEELHQRAQKQANLRDLFNQSQDLLMTESERSDIFLSQVLPAYCAFYDADPGPHVFETFYDIRTFIVVLARHLVSGIRSVPDTTNKTESSKVLMDNLRSKLHLYYVLKAINISTFGPNVLVTVMLQQRVPSVVIKLFRSFIDLPRSYYDTETKQGVSDSMVTLEDAGNVVVDTLKQCVKNPSVLTRLIVEDTFFLLLRLILAKPAEWIASPNDGETQEPGYMVWKHKYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UKK8</accession>
    <name>A0A162UKK8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_62991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294852.1">
        <property type="nucleotide sequence ID" value="XM_018441051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UKK8"/>
    <dbReference type="GeneID" id="29001957"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_62991"/>
    <dbReference type="InParanoid" id="A0A162UKK8"/>
    <dbReference type="OrthoDB" id="10372389at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="677" mass="79321" checksum="76E0AEF44AAFC14B" modified="2016-07-06" version="1">MLASELPFEILHKIGMFLCQSDLVKCTMVSKTWKQPFLEALWRFRLIIKPSTLDAILDTTSKENIYTKYGRHTRELGFAGPIVLKQGSIFIIQQRFQNLKALNLLMLDGQIIDLGGLADWDLWSTLTYLTINANLLNPVSGKDEIINAFKCLPKLESLIVQQDEWRKVLEFSLTDFENLHTFLPCVRTLKLDASLAELTNADAELLTHVTPALDLSFASVCFGAKDLRWLYYFAQKYPNVRILDCKSSDQYITQYTHQTETASMLSKLPSVFPHVKKAEFWSPSNSDDLLIILCGLLHPFNVPISHLKYRFRHRLREVVSPDEKIQQCTRLLPKTLTTLCIINQQNTRLSRFNTTALRYCPNLVYLSISDRDAFISFDLLLDFCQHLKIFKLDQGLLLLSTETSFDSPNHGLEAIDISRASISVPTFEYTSIRCELLECMRLNDVKIVGAIEKRTGSFCISMAFTSFRLLHLNKVQFYPTDYITVNKPIHLVVLSRYTTVTQNNHHPKRHTHLREDYYPREVFEYMWHHTYCNDRSDYDRLPQTRMLTRKETKIARRYFRSSRRNKHIGEDDSADRSIEGHVQENEWEKDLHRGYVSFFCQYIHKYEFGGNMMYSLDIKTMIQYSIYSHLSKVRFYRKGFNITSTDIQTFKYTEYDTEYLLILNIRYINLEEIYLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ULF1</accession>
    <name>A0A162ULF1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_165410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294952.1">
        <property type="nucleotide sequence ID" value="XM_018435234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ULF1"/>
    <dbReference type="STRING" id="763407.A0A162ULF1"/>
    <dbReference type="GeneID" id="28996140"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165410"/>
    <dbReference type="InParanoid" id="A0A162ULF1"/>
    <dbReference type="OrthoDB" id="2442555at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="41013" checksum="B891B3EEAC74676B" modified="2016-07-06" version="1">MPTSNNSLEFVMDKHCEMVSHSSSADQTQFSGIAFDPLCDFNQEIVDEMHGEVVLRSVTDVFVNHADMEWTRTLAGNSAVTNLLSLKSFLPTEVNEATTKTIVAQKPKTNLPEKVDPDSVPTAESIGRGSYRKYNQNQMNKLFSLVFSENQTAAATARETGINVRTAQNYVRLAREKIQADFDAATVETDESNGLETMEVEEFFENKPDATLEQARIAVMEEFSGLQITKSAIQKHLVKKCALTMKKLEKLPEKRDDINTIEMRRDRILEWQQLADFNYLSNCVFIDEAGFNMHIKRTFGHSISGTPAKTTVPTQRGVSITILGAMCERGIVSRSLKKPTAVATKKKRKLDIYTNVEVNSQIGTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UNB9</accession>
    <name>A0A162UNB9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_63247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294583.1">
        <property type="nucleotide sequence ID" value="XM_018441091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UNB9"/>
    <dbReference type="GeneID" id="29001997"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63247"/>
    <dbReference type="InParanoid" id="A0A162UNB9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="142" mass="16309" checksum="EAE63BED04D44BF1" modified="2016-07-06" version="1">MLDIRFFNARAFFDQKPLHVSPVNGYIDITVAIAKIQEFLHVTKGGSIRIIKQEKKVVKRQIYDSSSSSTFCKNCKKVGCRSMRSPGCSKYITPKEELLQENLGTYHNSFTRKLSLRIVIHANLQRLFKKKSSRLQKTLSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UQ79</accession>
    <name>A0A162UQ79_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CYP5025 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_108369</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295462.1">
        <property type="nucleotide sequence ID" value="XM_018428048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UQ79"/>
    <dbReference type="STRING" id="763407.A0A162UQ79"/>
    <dbReference type="GeneID" id="28988954"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_108369"/>
    <dbReference type="InParanoid" id="A0A162UQ79"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF50">
        <property type="entry name" value="BIFUNCTIONAL ALBAFLAVENONE MONOOXYGENASE_TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD77422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="520" mass="59314" checksum="D9B2C03F34A4B3A2" modified="2016-07-06" version="1" fragment="single">MSPKEEILLLDDSENILNSRASIQNQQLVYVDLKDHIKHTIPGPLNIPFVGSLYEMLPNITESWVRQFEKYGPLVSVSILGTEMINTNNVDIAEIFSKESEYFTKRIKGSVLSEAKRVGLQGLFTTDTDETDWRLAHQLLMPAFSSRAIKAYQIEMGRLVQQTIRIIEQIPQDGPVDIIDLSTKLTFETIGRIGFGYKFGLIDSLNSPSHPFIGAMSYCLQQAVVRTQQARFVRSLPTEANRTFDRSLKLMHDIVDKVIQDRKRVPKSDTDNSESDSDSDSNNNKDLLDFMLYARDENNLGLSDENMRDQVVTFLIAGHDTTANTVAWALYEISRSPEVEAKIVQEIVNAGITAEELPTSEQISDLKYITQVIKETLRRYPPIRIISRICKKNCVIPGGYLIKKGSSVGVHLYSLHHNPEIYPNPYRWNPDRWTPEEEQKRSRYSWMPFSTGPRACIGMAFSLQEMKTSLAMLLQKYRFIYDGPPIQFDPKMATTKPYSFMMTVKPRTSFPQSNVSLKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UXY0</accession>
    <name>A0A162UXY0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CCT-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_122100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296753.1">
        <property type="nucleotide sequence ID" value="XM_018428850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UXY0"/>
    <dbReference type="FunCoup" id="A0A162UXY0">
        <property type="interactions" value="987"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UXY0"/>
    <dbReference type="GeneID" id="28989756"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_122100"/>
    <dbReference type="InParanoid" id="A0A162UXY0"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03336">
        <property type="entry name" value="TCP1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000025">
        <property type="entry name" value="Chaperonin containing TCP1 subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000002">
        <property type="entry name" value="T-complex protein 1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012716">
        <property type="entry name" value="Chap_CCT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD78713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="526" mass="56766" checksum="588007DC5CACF2DE" modified="2016-07-06" version="1">MSLAPVQIFQDQASEEKAENARLSSFIGAIAVGDLVKSTLGPKGMDKILQSATTGEILVTNDGATILKSIALDNAAAKVLVNISKVQDDEVGDGTTSVCVLAAELLREAERLVNQRIHPQTIIEGYRLASAAAYNVLEKSAIDHSKDKAAFREDLINIAKTTLSSKVLSQDKEYFSKLAVDAVLRLKGSTNLEHIQIIKKPGGKLMDSYLDEGFILDKKIGVNCPKRIENATILIANTPMDTDKIKVFGARVRVDATGKLAELERAERNKMKVKVDKIKAHGVNCFVNRQLIYNWPEQLLADAGVATIEHADFEGVERLALVTGGEIASTFDHPELVQLGHCDLIEEIIIGEDKLIKFSGVAAGEACTIVLRGATQQLLDEAERSLHDALSVLSQTVKEPRTVLGGGCSEMLMSKAVDEVAAKTAGKKAIAAESFAKALRQMPTILADNAGFDSSELVAQLRAAHYEGKSTSGLDMVNGKVSDVRVLGITESFKLKKQVLLSASEAAEMILRVDNIIRCAPRQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V296</accession>
    <name>A0A162V296_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_139517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297522.1">
        <property type="nucleotide sequence ID" value="XM_018430241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V296"/>
    <dbReference type="GeneID" id="28991147"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139517"/>
    <dbReference type="InParanoid" id="A0A162V296"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD79482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="144" mass="15389" checksum="E2280BE951FCD998" modified="2016-07-06" version="1">MGPRTNINQNACTNGSASRPLINAVNTDCIGLSNPMIAPRPDNISIPVSEFNDVISLLATLNDKMTAVSSNVSELKIQCQVGAQSTDMQAVLDSDMSSQDIISSSRHPKISFNKNLASDFMLYIRCQPVAAMVPPKGLCGICCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V2W9</accession>
    <name>A0A162V2W9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_162649</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297632.1">
        <property type="nucleotide sequence ID" value="XM_018434675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V2W9"/>
    <dbReference type="FunCoup" id="A0A162V2W9">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162V2W9"/>
    <dbReference type="GeneID" id="28995581"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162649"/>
    <dbReference type="InParanoid" id="A0A162V2W9"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052246">
        <property type="entry name" value="Cell_Polariz_PKAAnc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155">
        <property type="entry name" value="A-KINASE ANCHOR PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="184"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD79592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="389" mass="44319" checksum="45FA1B569DE633CD" modified="2016-07-06" version="1">MTTKAIPSDLPTLDDVLNRRTLPPVCLYNFYIVMRDRLHMEEILDFYLDVKHHELLWKRYIKSLQRSGFVTEEDLAEGYQSNRLLSRLSHTSSMDEKRPGLSHLSSPTTRPHHLQPPRSMDLGERSGNSIRISQSSGLSNIPVIRPPIIDPSITVTPRQPVDEEAAGVLTTESMVSGNPSVLPPNRQDLANSAQRILLKYIVPSAQKELVQLPPPIRQAIRDALQGPEPRDDPLVYADAKQYAFEAMQRQAYPKFLRLKVWGNVTLWQQLGRLAIGLLGLLAGFATSLSLIFLGYPQWHSRFGALVPFWVGIYNVFVFLTGLDPLWRRSLSRKSLFFIYSETVTFRFNKIAQPRVKEILWSRSIWLLIASIVVSMVITIIFSAIPPRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V9V6</accession>
    <name>A0A162V9V6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_157079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299183.1">
        <property type="nucleotide sequence ID" value="XM_018433558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V9V6"/>
    <dbReference type="STRING" id="763407.A0A162V9V6"/>
    <dbReference type="GeneID" id="28994464"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157079"/>
    <dbReference type="InParanoid" id="A0A162V9V6"/>
    <dbReference type="OrthoDB" id="10619689at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD81143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="132" mass="14836" checksum="B962D965C22DC14B" modified="2016-07-06" version="1">MNTGYNTSNVIISRDVTEQDAYEYYIHNQPPQLPSSPLATYSHQQQQQQQPIQRATSKRAQQSQSPHVASVSSMDRISTPTGGNVFARLSQTPTRASRAKVAYRHSSGSVDDLKRRWDLDQQQRTVSSLSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162VAP5</accession>
    <name>A0A162VAP5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_92569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299363.1">
        <property type="nucleotide sequence ID" value="XM_018443793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162VAP5"/>
    <dbReference type="STRING" id="763407.A0A162VAP5"/>
    <dbReference type="GeneID" id="29004698"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_92569"/>
    <dbReference type="InParanoid" id="A0A162VAP5"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000093">
        <property type="entry name" value="NLI interacting factor-like phosphatase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="1">
        <location>
            <begin position="9"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD81323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="187" mass="21545" checksum="F2201D45E98A1247" modified="2016-07-06" version="1" fragment="single">NPVKKNSHLYYKGKTLVLDLDETLVHSVRLGSPDDNHTISTSIKRKKIEVQNDHQSILYEVYKRPHVDFFLKTISQWYKVVIFTASMAEYADPVIDWLDQDQHIISQRYFRQSCEYRNGDFLKDISLAEPDLSKVCLVDNSPAAFGLYKDNGIPLTGWISNPQDQCLLDLLPLLDALRFTADVRSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162W9M9</accession>
    <name>A0A162W9M9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_153344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441009">
        <property type="protein sequence ID" value="OAD65655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283695.1">
        <property type="nucleotide sequence ID" value="XM_018433119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162W9M9"/>
    <dbReference type="GeneID" id="28994025"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153344"/>
    <dbReference type="InParanoid" id="A0A162W9M9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="101" mass="10727" checksum="5E1179A0925327F4" modified="2016-07-06" version="1" fragment="single">MTKHIPTAPRRPNLCMNAVLNSTIAGVVAPIDTPTPEVAVDTAPEVQVAVTPMDHVLTLLAANNVSMQSLQENAKGVTDAITHLKNGLDLSNKTNEFLKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XBZ8</accession>
    <name>A0A162XBZ8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Homoaconitase, mitochondrial</fullName>
            <ecNumber evidence="5 17">4.2.1.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 17">Homoaconitate hydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">PbAcod</name>
        <name evidence="20" type="ORF">PHYBLDRAFT_186941</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 17">Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>(2R,3S)-homoisocitrate = cis-homoaconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15485"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:58174"/>
            <dbReference type="EC" id="4.2.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.36" evidence="5 17"/>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291865.1">
        <property type="nucleotide sequence ID" value="XM_018439302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XBZ8"/>
    <dbReference type="FunCoup" id="A0A162XBZ8">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162XBZ8"/>
    <dbReference type="GeneID" id="29000208"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_186941"/>
    <dbReference type="InParanoid" id="A0A162XBZ8"/>
    <dbReference type="OrthoDB" id="10262323at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER01027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004409">
        <property type="term" value="F:homoaconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01674">
        <property type="entry name" value="Homoaconitase_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004418">
        <property type="entry name" value="Homoaconitase_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039386">
        <property type="entry name" value="Homoaconitase_swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00139">
        <property type="entry name" value="h_aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="11 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="13 17" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="18">
        <location>
            <begin position="59"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="19">
        <location>
            <begin position="518"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OAD73825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="709" mass="76595" checksum="2A84E528213E24D8" modified="2016-07-06" version="1">MLLTLSKTNMVRATLRSSPVRFTPYASFHQASEATDTQNLIEKIVQKYALDLPEGYKVKSGDYVSIRPHHLLTHDNTGPVIPKFKSIGATKFYNPKQPVFALDHDVQNKSEKNVTKYANIEKFAKEHGVDFYPAGRGIGHQVMIEEGYAFPSTLTVASDSHSNMYGGIGAVGTPIVRTDAAAIWATGQTWWQIPPVVKVELKGNLPTGVTGKDVIITLCGLFNKDQVLNTAIEFHGADALKALSVEDRLAIANMTTEWGALAGVFPVDDLTIDFLRKRMRRIALSHFENKNLPPTPPGQDFVHPRINESTIQELIDNPIKPSPNATYSKTLTLDLSTLSPHVSGPNSVKVASSLASLEEQDIKINKAYLVSCVNSRASDLRQAAAVIKGKKVKEGVEFYVAAASSEVQKEVEESGDWDILLKAGAKVLPAGCGPCVGLGTGLLKDGEVGISATNRNFKGRMGSPSALAYLASPAVVAASAVLGKIASPGSVESGSKLSTAPVPSFSIETNEQKQASGTETAAAEVLPNFPNVIKGELLFCHQDNLNTDGIYPGKYTYNDDMTTEDMRKVVMENYDPEFVNIVQEGDVLVGGYNFGTGSSREQAATALKSRAITIMVAGSYSDIFKRNSINNALLLIESPELVNDLKEQAGTDTLTKRTGWEVEIHVAEGKVNVKKDDGSSKLYKVGGLGKSVQEIWLANGLEGWVKNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XCC0</accession>
    <name>A0A162XCC0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3020 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_186976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291935.1">
        <property type="nucleotide sequence ID" value="XM_018439308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XCC0"/>
    <dbReference type="STRING" id="763407.A0A162XCC0"/>
    <dbReference type="GeneID" id="29000214"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_186976"/>
    <dbReference type="InParanoid" id="A0A162XCC0"/>
    <dbReference type="OrthoDB" id="5595797at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021386">
        <property type="entry name" value="SPP41_DUF3020"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11223">
        <property type="entry name" value="DUF3020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3020" evidence="2">
        <location>
            <begin position="153"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD73895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="492" mass="54165" checksum="9317F4AF51950267" modified="2016-07-06" version="1">MELKEEDLAVNHHTETDDVKNDSPDKNCHQMVALDKVEDESVNQDTNATTAQHVADAFANALFQHYSFTMPTTEEKDVTTGLPMHAQLVAAVVAAAAAAEKNGPHGSIDYGFTPTPDPATTSAPSMDQTMFDGQMVPGSLKRNLMKLKVREDNRARKKRWREHNEERNKDNDLRCRVNKRAHKLFGKDDTTHKKQWVEEEFQRRRAKRQEKERHKQAMDGALHATHAAALKLNQDLSAFLKFSKESNASAAALVAALQSPQLLQLLTQTAGAIQTSTATSAITNSPTQTHQTQIQHNQNQAHSQNQGQIENQNDSQGQSQSQNHIHSHSHNHNHNQDHQNEIQSHNEIQSHSQNQIQDQIQIQNQDQDQDQSQSQIQSQIQEQTDLASTIASAIASTTTTDTTIAETGEHILATSTSDSTASVTNDIVSDTGIAIVSDSAADSATATTQVQPEENEVSAKEDESGTGTGGTQTDSMDAVMTLMQLNGSWRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XHA4</accession>
    <name>A0A162XHA4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_167215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292915.1">
        <property type="nucleotide sequence ID" value="XM_018435600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XHA4"/>
    <dbReference type="GeneID" id="28996506"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167215"/>
    <dbReference type="InParanoid" id="A0A162XHA4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007840789" description="Transmembrane protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD74875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="23112" checksum="28FE070332F73BE0" modified="2016-07-06" version="1">MQCDLQKYHFYVYLAALRLLLSESLVLSASCRITFENPIVLYHSKCDQRKLSFDKLFENLLFQISENNLFIIQLKSRELKQLKHSSKNRKQVQLAMNKNSNFMEANQINKFENNHLFPIVIYLISKYLAIKSITVKAQYSDMDSEQKFYYYHYIKHDFFLLRALFSDISNATVILTTAVVESLSCTVVIVFCMIISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XPS9</accession>
    <name>A0A162XPS9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted cell wall surface anchor family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_59569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294075.1">
        <property type="nucleotide sequence ID" value="XM_018440520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XPS9"/>
    <dbReference type="GeneID" id="29001426"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_59569"/>
    <dbReference type="InParanoid" id="A0A162XPS9"/>
    <dbReference type="OrthoDB" id="10436706at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007840837" evidence="2">
        <location>
            <begin position="21"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD76035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="287" mass="30307" checksum="FD440F712128C828" modified="2016-07-06" version="1">MQIYYLTAALVILVAITAQAAPLSERAAGESLDKRSGVTVNSSPSIHQEFTSTDASTRPAKDDEPKNHAKRSGITINSSPKIDEKFTSIDSSTRTAKDVGSNNHAKRSGVIINSSPSIHDEFTSTDSSTRPARDDGPSNHAKRSGVTVNSSPKIDEKFTSVDSSTRTPAQNGKTANAKPASVIIYAGPTIQQEFTTTDVSPYENEANEPRSIERSSGRDAPIARSLFTRAGNSPAAPGTPDIPKVPDVPTIPNGSTTPEAPKIPDIPKIPDIPKIPTAASIDVANID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YAW7</accession>
    <name>A0A162YAW7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">NDUFB7</name>
        <name evidence="13" type="ORF">PHYBLDRAFT_179103</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297475.1">
        <property type="nucleotide sequence ID" value="XM_018438102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YAW7"/>
    <dbReference type="STRING" id="763407.A0A162YAW7"/>
    <dbReference type="GeneID" id="28999008"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179103"/>
    <dbReference type="InParanoid" id="A0A162YAW7"/>
    <dbReference type="OrthoDB" id="268414at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD79435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="78" mass="9501" checksum="2C22FC76B6C80FE2" modified="2016-07-06" version="1">MADAPEMKATQQELKKARIPIEYRDYCAHLLIPLNKCRGETFYLPWKCENERHEYEKCQYDDYKRRMVALKKAKEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZER6</accession>
    <name>A0A162ZER6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_71167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441004">
        <property type="protein sequence ID" value="OAD66251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284291.1">
        <property type="nucleotide sequence ID" value="XM_018442419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZER6"/>
    <dbReference type="STRING" id="763407.A0A162ZER6"/>
    <dbReference type="GeneID" id="29003325"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71167"/>
    <dbReference type="InParanoid" id="A0A162ZER6"/>
    <dbReference type="OrthoDB" id="6141723at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="290" mass="33502" checksum="F5DE9EA625B7E9A5" modified="2016-07-06" version="1">MREYRLKYQQFTEVEVVGAKVEVHNSRIEYMRQYRRNQRLRAAEDNERVIRRHRLDDEVETNSWGSIWRKYSLTKSEERLVSSRHVFQSSWTHKGLSRKYRSKGGIVNVPVDVDTAVPSLSCNLNGTNTIYLSLSRRMCYVKDYIRSNTSPAKVWREIIFLQSTPLYQEYNITLSNDWIEDITKSNTEIARTDGAEGQDNSAEEIVEGELEDHGNQRTVLLSDHEATRPSSGNGRIPLSALTVRGSDFLSFPKIFCGQRLSIPENVFCSSLTKSISRRVRRAARAVNYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZF60</accession>
    <name>A0A162ZF60_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial genome maintenance protein MGM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_119220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGM101 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441003">
        <property type="protein sequence ID" value="OAD66401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284441.1">
        <property type="nucleotide sequence ID" value="XM_018428670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZF60"/>
    <dbReference type="FunCoup" id="A0A162ZF60">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162ZF60"/>
    <dbReference type="GeneID" id="28989576"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_119220"/>
    <dbReference type="InParanoid" id="A0A162ZF60"/>
    <dbReference type="OrthoDB" id="17164at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009446">
        <property type="entry name" value="Mgm101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404:SF0">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06420">
        <property type="entry name" value="Mgm101p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD66401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="195" mass="22418" checksum="5F91FFCCF8B6FEC0" modified="2016-07-06" version="1" fragment="single">NWSTSFHGLSTQPFSSEISNLLMQPINESDIEVKPDGMIYLPEIKYRRILNIAFGPGGWGLAPRGEHSISPKNVSREYALVCHGRFVSQARGEQDYFDVSGLPTASEGCKSNALMRCCKDLGIASELWDPSYIRKFKKKHCVEVWAEHQVTKRKKKLWRKKDETIGQLFELNVFFPILYFSVITNINTRNQIKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163A406</accession>
    <name>A0A163A406_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_170999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288961.1">
        <property type="nucleotide sequence ID" value="XM_018436465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163A406"/>
    <dbReference type="STRING" id="763407.A0A163A406"/>
    <dbReference type="GeneID" id="28997371"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170999"/>
    <dbReference type="InParanoid" id="A0A163A406"/>
    <dbReference type="OrthoDB" id="2443300at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="738" mass="80978" checksum="A173E108F912F523" modified="2016-07-06" version="1">MLSKMGVLSQIDRSNSCVNLGQWYQFVVEDTKRQNSSALADKDSTSVFFHDKFPDFMRFLQGINCLLLCTIFWHIMKPPIGQRVRVQNSKSNGCEVVRLKSGEGAAILRGRHSEWLPPLPYPTRLNKAHHTNKNHPPKLIHFGHASLLPNEYLLLTTTTPLKTIKPTPSSCLRMSSIMAVPLAVSSSMSLANVTVLATSGLETGAVIQRVSLSRLPIFDLADLLYGLQTSLVLYRRILNGGICREPNFQTFFSGWTPRTVSILPRAPCPFGVVIAMLTIMTVRAAPNARPTNDSVGYVTKLGTTAELDAENSHTAVQETVAKQLTAQEAMDQEVTSKALEERVTSEQEANALVANLAAALFAKDNEIAALNATLTRSAEAKALATQQELETNRASIVALTSSPAGATGTSTVIPHNTVILPGLSKHGQALKDLRLHHKPKAPLGKIGKSIPAIMKTATVTATDPSQSDYRAILAKVTHMSSSFDPFFILVVYETASPAARATFYSDLQSFAILNNPIIQDRLFILGDFNFSFLKPTSLCTAPLSWQHYLGSYFVNCHTSLDPTLLPIFSRSSSTTTIDCMFAAYSMSLSIVNHDIQFISPLWTDHALLQTTICLGTSDKRRGLGVLTLLLPQTPTFFLLSIPLSIASFLSFPIMIHNASRKSSKLLRLGPPRNLVDAILHIGEKKLLKSLQSKWSQFLQSKPILAVRLLLLPKYDQQIAAIQQELVNATSLRAGLRWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163A6E7</accession>
    <name>A0A163A6E7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_114483</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289421.1">
        <property type="nucleotide sequence ID" value="XM_018428396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163A6E7"/>
    <dbReference type="STRING" id="763407.A0A163A6E7"/>
    <dbReference type="GeneID" id="28989302"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_114483"/>
    <dbReference type="InParanoid" id="A0A163A6E7"/>
    <dbReference type="OrthoDB" id="17410at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF8">
        <property type="entry name" value="POC1 CENTRIOLAR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="112"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="161"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="203"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="252"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="294"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD71381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="332" mass="36730" checksum="D6C40BD6FCEBEB58" modified="2016-07-06" version="1">MYLLLSNRFNPDVNRRLNIDLVHSFDHDGVVCSVKFSPDGYFLATGGNKLTKIYDTTYGALIAVLQDENAGENESYIRALSFSPDGRYIATGSEDQKIRIWDIAKKCITRELIGHEQDIYSLDFSKDGRVLLSGSGDKTARVWDWVEGTCLHKLEVLDLEDNINNTSVTSVSVSPDALLVATGSLDSMIRIWDIQKGELVEEFSGHGNSVYSVGFMPDNNSVVSGSIDKTACLWKLGSSRASGDEEACKQKFVGHKDFILSVATTPCGEWIISGSKDRNVQFWDPHTGENQFLLQGHKQSVLSVAASQGKRRLFATASIDSKARVWSYDLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163A8D1</accession>
    <name>A0A163A8D1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_72820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289791.1">
        <property type="nucleotide sequence ID" value="XM_018442726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163A8D1"/>
    <dbReference type="GeneID" id="29003632"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_72820"/>
    <dbReference type="InParanoid" id="A0A163A8D1"/>
    <dbReference type="OrthoDB" id="2389915at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="481" mass="54474" checksum="9ED33244BED26A8B" modified="2016-07-06" version="1">MEIDKDISYKCGCHFEDSEGEAHIYYSNRIGSNTFTKAELMSIHLSQLMLRHRISRATYRDIVQFVNTIIPDYNEIMLEPGAKISHGKTVDALLKSKSSVKDYEYDVCPNGCPFQTPSASMKLMSVSDMFSQMLTDPATRELLHYRANRESVAGQLTNIFDGYSYKQLMQQGLFSNPDDIVIRLYTNGFINQKKGKSSYTIVHAVVFNLVLSIRYTNEYLLQLAILPGPKKPTHLDSFLMPIISKIKDLEVHDLVIKSNGVEVCHAKIHLLLAFVCLVAESAKQREKPQTTDGTECTLKIVLLLCDLWKTSKLAILELSTFSRSSFFALDELHLVARGIGKHIYNLITVSLTKETKFFYTHPDDTLSTTEYPFFIPRTGLVTIGNCITSSRPYISVLFQGSFDNVFSIIDSTHAVDWLDFLLYIVPTLVVPFLPNRAVKTAVLSLVKGCALTLQWTLTSELLDEMDVQVIMPLTLYYYIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AYS3</accession>
    <name>A0A163AYS3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RecQ mediated genome instability protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_157966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294671.1">
        <property type="nucleotide sequence ID" value="XM_018433707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AYS3"/>
    <dbReference type="GeneID" id="28994613"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157966"/>
    <dbReference type="InParanoid" id="A0A163AYS3"/>
    <dbReference type="OrthoDB" id="341511at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="20856" checksum="0582E00EA37EF7DC" modified="2016-07-06" version="1">MAQERTEDDSIPDDMSRWMEDNLVVLDDDDEIQIKQEKDSQKDEPINTCASLRRLLLRIKSSINCTHPDQVLLKCKGSKLGKLRVHPASGYYLVVHLVDPDTDNPNEDVAVVFGDKFISELSGKPYSEVHALDKHDKSKSELKKAIGKCHSKLLKTIAFVKLDLTMMETAEDGTPMPNVIEYTPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163CTH5</accession>
    <name>A0A163CTH5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_176092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441010">
        <property type="protein sequence ID" value="OAD65500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283540.1">
        <property type="nucleotide sequence ID" value="XM_018437653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163CTH5"/>
    <dbReference type="GeneID" id="28998559"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176092"/>
    <dbReference type="InParanoid" id="A0A163CTH5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="742" mass="84646" checksum="C26D0F7E7DF7FD04" modified="2016-07-06" version="1">MSTISELYNEKCHCAGCSQNDLGYSFVARRTAQRHNKRASLNTIRCERDMSTQRNMMEVDDEPILTHQPGALEESYTQTNSPVWEGASMSDTEDVSITNDAISNGNNDDSGSNSNEISEDESEDDVIELDNNELNSEDPFATPDMPQNPVHRFIATFVVMFASRYVVDKGAVVLIEFINKLLTIYEQDFQLPLSLPGLQHMTGFSAMTKGIKKFVVCQDCHKVYEESASVPSHCDFVKLGARLSCNCQLMKTSASGALVAKRSYLYQSILHRLGYLDLVRGTIIDPMHNLFLGTPKRLMDRWIKDEDIQDGHFAAMQKTAETMIVPGGYTSLNSKIGKQFSYMKADEWKSWVLVYSPVLLKDVLAKDRFENWINFVDACHLLIKPMITFDEVNTAHQFLQTFCIRCDELYNTEILTCNMHLHLHLRDTIRDFGPVYGYWLFGFERFNGLLKNLKTNRKIGFEETFMKKFIEDVHKDDLVNSFLQSTCQTSAFPLLTKLTSSFTPATIPSIRQHTFRIQSFVEASEDPNVLVKGNEPLPPSTFPLSLKSATTMSDIHYVHLLQYYKVAYNNEQLVHFQQASESPYFVDNTITLLKYINILGQVYKGKGESGSRGSLVQAKFIGSTGEHIIAYTGQIQYIFTHSFTPPPTSSSLTPLLRTHRRPTQLLHNSQHTFAFIKWYTSENDKSQEYEHVETCFPTFSPDDFQCVLPVHRIMLEVATAEHTTRRKVKKMLVIPLPKKQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163CXZ4</accession>
    <name>A0A163CXZ4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_175230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441003">
        <property type="protein sequence ID" value="OAD66420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284460.1">
        <property type="nucleotide sequence ID" value="XM_018437453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163CXZ4"/>
    <dbReference type="STRING" id="763407.A0A163CXZ4"/>
    <dbReference type="GeneID" id="28998359"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175230"/>
    <dbReference type="InParanoid" id="A0A163CXZ4"/>
    <dbReference type="OrthoDB" id="7700939at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD66420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="727" mass="83469" checksum="BA10F73F9148FE07" modified="2016-07-06" version="1">MAPTRKSNKTKGCKCSVCKTRFGGSDTVSVQTFNFHKRRDDAGMNIFRNRLIIKRSVETTVSYVPEVINNDEQNSVAIDNDYDMDYDFDEMDTSIEVDMETQEPIRVLPLSESDAVFGYENEEFNSDLDSDGCEDDSSEDDMLDSEDNFPEFNSELSFIHRFIVQVLALFVSLYVVDEGAILLIAIMNKILELFRDPFRLPVSIPGLKSMAGFNTFTDGIKKYVSCSECHSIYENDESTPRFCIFDKFGNNSMCVENGVRWSELHRLQYFDVVRCTIIDPMHNLFLGTAKRMMEKWVADGLIDNKKLVAKQKIVENMTLPPDYTMLRSKISKGFPFMKADEWKSWCLVYSPVVLQGVLPKQKFENWMFFVNACRFLTKPNVSEDDVHSAHIALEKFGKGYERLYSKDLLSPNMHLHLHLRDTIKDFGPVYGYWLFSFERYNSVLKNINTNRRSCFEMTYMKTFIEDTRKGDFVRNFLKTSGPFNFSGIFDKLVTGYSPADSTTSTALYNWFSLPDFLDAAENPNLSIRGNEPLPPSALPLQKKAYEMMPRQEYDCLVGYYQAVYNDPTISSCKDVIQDTAFVNDWIETLKSVNLLGQTFKGSRGTNGRGSCIQAMFIEGRNGAKYAYVGEIQYLFVHSFSPLVSTPHHRTPQSSQHTFAYVKWYKASKETSRKIAGVEIWDVAFSLPDFQSILPVHRILLPVAIVDHTTLRNISKKLIVPLPRKLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163CYB1</accession>
    <name>A0A163CYB1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GATA-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_104343</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441002">
        <property type="protein sequence ID" value="OAD66490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284530.1">
        <property type="nucleotide sequence ID" value="XM_018427841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163CYB1"/>
    <dbReference type="STRING" id="763407.A0A163CYB1"/>
    <dbReference type="GeneID" id="28988747"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_104343"/>
    <dbReference type="InParanoid" id="A0A163CYB1"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF335">
        <property type="entry name" value="IRON-SENSING TRANSCRIPTIONAL REPRESSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD66490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="52" mass="6093" checksum="8C3F0E2174B841D5" modified="2016-07-06" version="1" fragment="single">MMCSNCHTTTTPLWRRDSAGNTICNACGLYYKLHLVHRPVAMMRTVIKRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163D6I9</accession>
    <name>A0A163D6I9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_150102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD69110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287150.1">
        <property type="nucleotide sequence ID" value="XM_018432402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163D6I9"/>
    <dbReference type="GeneID" id="28993308"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150102"/>
    <dbReference type="InParanoid" id="A0A163D6I9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="83" mass="9355" checksum="769A007297F0493D" modified="2016-07-06" version="1">MSEGESNDDMSPSQPRNEICVARPSWRSDELNKFITEVDSFVVKQLGANSRQLLKRVYGRTVESTVPIDLDPALPQWALKYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DC40</accession>
    <name>A0A163DC40_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_148864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288360.1">
        <property type="nucleotide sequence ID" value="XM_018432171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DC40"/>
    <dbReference type="GeneID" id="28993077"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148864"/>
    <dbReference type="InParanoid" id="A0A163DC40"/>
    <dbReference type="OrthoDB" id="2270519at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="299" mass="33769" checksum="334A33B671A30643" modified="2016-07-06" version="1">METTSDPSNDEVYVCKSMDMNDILSIKIVWSEEVEVNGSQHKKKRDKFDQNGHEIVGYIRKSTGEKDDITRIRLLNQISVNLRERSLVTKVFASFSCESNQPLLARDLKKNTGVLSGIIADGDMQVIDFTGLTTNPEDLEQFLKNSPNIVKIIIDKLPYTNTIHIYNSDELLNSPDKLQEFKCRSTVPEIVNLPGSLARRNQCLVVEYVLHSIVECRDLLYSISLCLFPQLHSVIPWSFARCMADENEEESGKKGGKKSEQDSFFVFFGQDSGQDNSSLLVEAVGRLLIHTMRGNRDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DCF3</accession>
    <name>A0A163DCF3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_187897</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit TRAPP (transport protein particle) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288440.1">
        <property type="nucleotide sequence ID" value="XM_018439435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DCF3"/>
    <dbReference type="FunCoup" id="A0A163DCF3">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163DCF3"/>
    <dbReference type="GeneID" id="29000341"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_187897"/>
    <dbReference type="InParanoid" id="A0A163DCF3"/>
    <dbReference type="OrthoDB" id="10254842at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000002">
        <property type="entry name" value="Trafficking protein particle complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017479">
        <property type="entry name" value="TRAPP_I_complex_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD70400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="210" mass="24074" checksum="A02715DCAB71BE27" modified="2016-07-06" version="1">MADPSNPPRTSLTTSTYGDQRTIRANKSILERSLNKTRGAEVSLNAQSYMFSEMLQYAQKRVNGIQDLEKRMNEFGYRVGTRLLELLSWREKVPKRETRVLGVLYFIHSVVWKALFNKQADSLEKSTENDDEYMISDNEPLLTRYISVPKELSQLNCNAYVAGIVEAVLDGCQFPARVTAHTVPIDGFPQRTTILIKLEKEVLQREELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DD01</accession>
    <name>A0A163DD01_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_135171</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288550.1">
        <property type="nucleotide sequence ID" value="XM_018429702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DD01"/>
    <dbReference type="FunCoup" id="A0A163DD01">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163DD01"/>
    <dbReference type="GeneID" id="28990608"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_135171"/>
    <dbReference type="InParanoid" id="A0A163DD01"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000166">
        <property type="entry name" value="Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF19">
        <property type="entry name" value="KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="101"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD70510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="426" mass="47770" checksum="A703F3B8D66F3FDA" modified="2016-07-06" version="1">MDYTKFMSERSQARNPSAIRALMPYMNCKNMISLGAGQPNPSTFPFESMQLKLKTGEIIDVDPQLFQRSLSYDLTSGLSPLNEWLRGLHTLEHTPLVDFGLSIGSGSQDLLTKAFDMVIDPGTAILVEDPTYTGALSFLDTLDCDLVPVATDADGLVPASLEKTLANWPESNPIKKKNQARPKVLYTIPTGGNPTGISSTFERKKAIYKICQKYDILIIEDDPYYYLQFDPKRIKSYVTIDTDGRVLRMDSMSKILSSGMRIGWVTGPKALIERIDMHTMVTNLQPGGVPQLMAYELLKVWGYKGFLNHVEHVAGFYKSKRDEFIKALEKRMTGRAEWVTPNSGMFVWLRLLGGITDSYDLVMNKAIKKNVLAVPGVAFMPAKNKNPYIRVSFSCVTTDNMDEALRRLAECIDEEAAKNHIQLKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DQB0</accession>
    <name>A0A163DQB0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_146160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290880.1">
        <property type="nucleotide sequence ID" value="XM_018431598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DQB0"/>
    <dbReference type="GeneID" id="28992504"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146160"/>
    <dbReference type="InParanoid" id="A0A163DQB0"/>
    <dbReference type="OrthoDB" id="5988651at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="58" mass="6151" checksum="4DFA6E32A24859A8" modified="2016-07-06" version="1">MSNNPHAQKSGGTHKSGGAKSQMTPKDAARIQSHSDRTGINQDFKSRAQSAADKNANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DRU6</accession>
    <name>A0A163DRU6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL15/eL18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_125360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD73030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291070.1">
        <property type="nucleotide sequence ID" value="XM_018429040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DRU6"/>
    <dbReference type="FunCoup" id="A0A163DRU6">
        <property type="interactions" value="540"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163DRU6"/>
    <dbReference type="GeneID" id="28989946"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_125360"/>
    <dbReference type="InParanoid" id="A0A163DRU6"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="72"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD73030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="145" mass="16342" checksum="267C9E40459048C8" modified="2016-07-06" version="1">MPTRLHHNRKKRGHVSAGHGRVGKHRKHPGGRGLAGGQHHHRINMDKYHPGYFGKVGMRHFHLKQNQYWRPIVNLDSLWSLAGEGVREKYKNTEKVPVIDALQHGYGKVLAKGDISQAAIVRTRFVSRRAEEKIKAAGGVVELIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163E165</accession>
    <name>A0A163E165_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_144026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292690.1">
        <property type="nucleotide sequence ID" value="XM_018431130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163E165"/>
    <dbReference type="STRING" id="763407.A0A163E165"/>
    <dbReference type="GeneID" id="28992036"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144026"/>
    <dbReference type="InParanoid" id="A0A163E165"/>
    <dbReference type="OrthoDB" id="5537330at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052999">
        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180">
        <property type="entry name" value="CONSERVED MITOCHONDRIAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180:SF2">
        <property type="entry name" value="PEROXISOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26640" checksum="722C8ED510B5C653" modified="2016-07-06" version="1">MELNKVLREIQGIFKESSNPISNQLWYIIAAVIISALNHPKDLTEIYAILSNSLNDQEISLEFKEAETVKVVLRLREAILKSFIVTGFPKAINGLQHLYDTTPEAIRDMIQTTPLRSEDTWEDISIQRERGNSLFKKIYGRYTDLVLTHMGSSHPDLAQAALHQLYGSILSETKIIGAKETSLIMVACLLCDNLPAQLKGHRYGALNNGATQNELELVDSAVKLLCNYYAQAPLPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163E644</accession>
    <name>A0A163E644_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_165414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294960.1">
        <property type="nucleotide sequence ID" value="XM_018435236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163E644"/>
    <dbReference type="GeneID" id="28996142"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165414"/>
    <dbReference type="InParanoid" id="A0A163E644"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007842437" evidence="2">
        <location>
            <begin position="26"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD76920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="251" mass="28657" checksum="5F0AE1A45A456899" modified="2016-07-06" version="1">MKERLVWNFLVKVTISNVAASMGQGEEPEARPVNEYWRRHRNGSRREMRALLAIYFCCQFESGGIGRLGDQSKRKQKWTRIDEGVIKYCGGRRGDESPLEAAVKACVKKEDMVVSGALTRAWTLRDNVGRWCGSDYVRNWDLQTSSRSGYYTYKCMWQLFQGMKEYEQGALSSLEYERTTLWEQEEQPVIQIFGVMAVAIAVILKMVLTNGTIFVVKKSRGWDQANTIVEHLVAILDSADKVHPESVASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EAT3</accession>
    <name>A0A163EAT3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL6 alpha-beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_92545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295740.1">
        <property type="nucleotide sequence ID" value="XM_018443790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EAT3"/>
    <dbReference type="FunCoup" id="A0A163EAT3">
        <property type="interactions" value="324"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163EAT3"/>
    <dbReference type="GeneID" id="29004695"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_92545"/>
    <dbReference type="InParanoid" id="A0A163EAT3"/>
    <dbReference type="OrthoDB" id="540873at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_uL6_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="5">
        <location>
            <begin position="127"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD77700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="214" mass="23700" checksum="13F6AEB215A8A766" modified="2016-07-06" version="1" fragment="single">TRQLSSRALSTSAPVLSHVGRKPIAYAQEVSIEHDLTPIQTPRIPSELYNTTLTVRGPLGKQQLAIKPFVKLGFTLATDPTAEHVLEVGITDDSVKQQRSMWGTTRALINNAIVGVSEGYRVQLRLVGVGYRGTLENNERTIALKLGYAHPVNIELPEGVTCSIPQPNRLILQGVDLQQVTELAACIQRWRKPEPYNQKGIFINDETIKKKEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EC73</accession>
    <name>A0A163EC73_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_108391</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295940.1">
        <property type="nucleotide sequence ID" value="XM_018428050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EC73"/>
    <dbReference type="FunCoup" id="A0A163EC73">
        <property type="interactions" value="514"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163EC73"/>
    <dbReference type="GeneID" id="28988956"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_108391"/>
    <dbReference type="InParanoid" id="A0A163EC73"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000549">
        <property type="entry name" value="ABC transporter ATP-binding protein arb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000618">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="25"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="338"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD77900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="555" mass="62452" checksum="487A2804B2739C8F" modified="2016-07-06" version="1">MDKLKINVDRTATGNYSSQERSRDIKIESYSLNYHGRVLIDNATIELNFGRRYGLLGANGSGKSTFLTSLAERDIEIPEHIDTYLLNQEAEPSDMNAVEAVILHAQKEVARLEKQVEELLSQDDGADNPLLDDIYERIEGMDPSTFEARACSLLSGLGFNTAQMKKATKDMSGGWRMRVALATALFIKPTLLLLDEPTNHLDLEACVWLEEYLKTYDRILVVVSHSQDFLNGVCTNTMNLNHKRKLIYYGGNYDMFVKIKEENEVNQAKAYEKQQEEIAHIKKFIASAGTYANLVRQAKSKQKIIDKMEAAGLIEKVEKPQAFKFAFTDVDKLPPPVLAFQEVSFAYSGKVEDCLYRHIELGVDMDSRIALVGPNGAGKSTLLKLMSNELVPTEGRVQRHTALKLGKYSQHSNDQLEMDLSPIDYMKKHFPHESTQTDHWRQQLGRYGLTGAHQTSPIAHLSDGLKSRLVFAELAVLHPHIILLDEPTNHLDMESIDSLANAINSFKGGVVLVSHDFRLISQVAKEIWLCENGDIARFPGSIAEYKEGLRKKVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ED22</accession>
    <name>A0A163ED22_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIH1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_164913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD78030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296070.1">
        <property type="nucleotide sequence ID" value="XM_018435097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ED22"/>
    <dbReference type="STRING" id="763407.A0A163ED22"/>
    <dbReference type="GeneID" id="28996003"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164913"/>
    <dbReference type="InParanoid" id="A0A163ED22"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050734">
        <property type="entry name" value="PIH1/Kintoun_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012981">
        <property type="entry name" value="PIH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997:SF0">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08190">
        <property type="entry name" value="PIH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIH1 N-terminal" evidence="2">
        <location>
            <begin position="69"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD78030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="327" mass="36681" checksum="953DE02A517CDCE6" modified="2016-07-06" version="1">MPTLEILKEGHNSLDISGALRNSPQNFESLSDEDKAALMNQLASSFANDPKAMDRLASSALNNVTADDFDTVAVQPHPGFVCKTHIVNSKNPKHPVGKVVYINICHASEIPEPTLASEKDIQIALNGDPDSTYRVPLSMGQARTDKDNAGRLNLIMDSCFHTRAYIRAERDLEYRLYLLELSIEYVEDNENVVLSREFTMPNVISKGQIPKRILRLPKPSFISSLTIDKKKSELYLPWECKPRFSVFKGNTLIVVIPMPTVDTMLWTLDIEPNALIQTIQGKSSTITLPHTVDVTHVDNSAEFYKKSKDLVVRLTIVATSKIRQQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167J710</accession>
    <name>A0A167J710_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_176249</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="KV441029">
        <property type="protein sequence ID" value="OAD65337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283377.1">
        <property type="nucleotide sequence ID" value="XM_018437703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167J710"/>
    <dbReference type="STRING" id="763407.A0A167J710"/>
    <dbReference type="GeneID" id="28998609"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176249"/>
    <dbReference type="InParanoid" id="A0A167J710"/>
    <dbReference type="OrthoDB" id="2287175at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="4">
        <location>
            <begin position="397"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="499"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD65337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="626" mass="70537" checksum="7504371957F1C51C" modified="2016-07-06" version="1">MVMNMMNLPLMSTLQIKNFHFIQVPLICNHSLTPSESICASCRLSGHKRRSNMLCPLNNKNTRLYVPEKRTYKGISTNEEISAESSQSAALRLRHEVSSEETTQVQVQHVLESNGSNESDENDEDIESDDTESEDETDDSQSHGIARKNPLFSMCCNKGSVLLLDFEPTPSEMASLLVHGTAASNIFFQKIRAYNSTLSFTLLGAKINHSVANNRSGAYCFRIHGTICHNIGSVLPSTAEDLIKPRYAQLYIYDPVSQVNFQHNNASHLNQNIIEQIQSMLIRVNPFVSLFKSMEQYCRTENQVVNLTLRLVADSQQDQRRYNAPTAEEVAVLIMNNEPGTSRDIVLHTQSNGLQHINEYHRSYDSLHYVLMFPFGKDGWTITSCGTSGKKVTAMQWYSSRLMYCKNSLHLLHLFGRLFQQYIVDMYAKIEHNRIIFIAKNQKRLRVDLYSGVQDAMNLNDGNLNNLGRRFLKAFFLYYIWLLECIYCLTSVGVTIMTSNGPGGTGKTFVFNALLCHVCHQGKIALAVATSGIAALLLVDFQCCQFPVRLAFAMTINKSQGQTLDHVGLYLPSPVFGHGQLYVALSRIRKPSGIKIMVDIPDASTTQNTVYTDNVIYHEVFDEPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JE00</accession>
    <name>A0A167JE00_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_175761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441027">
        <property type="protein sequence ID" value="OAD65799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283839.1">
        <property type="nucleotide sequence ID" value="XM_018437569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JE00"/>
    <dbReference type="STRING" id="763407.A0A167JE00"/>
    <dbReference type="GeneID" id="28998475"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175761"/>
    <dbReference type="InParanoid" id="A0A167JE00"/>
    <dbReference type="OrthoDB" id="2418316at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="337" mass="39814" checksum="02A90096BB6D8C81" modified="2016-07-06" version="1">MKIYDLCLKLNREKMTHQQQQNYNKKDIALNMNSLKFFLNTIILSPHLGHDVMPLEHNVSYTVTFGTRRFASRTRRFLHSHVWDTTFCLSGTMDQIKLLDAGQQVTFYETAIEVKDSDSGQGKFCDSSFYVRKQYGYAEQQKVFFQKKSNEEKLKEYEVIESRLHKNKKYKKYFIGLCSILQQRSMYRNEAERYSLKRSCNNVATANSRCCALHIMERQPDFANQKSVLEGIVEGSGYKFELYSKYYCECNWIKTYWGAAKKEAQCKCAYSFQSLKRKINSFLDSVCPPEDDVSEKIQRYFHKSFIYINAYSLGHDAEHAFEIVKQFSKLHKYHRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JL23</accession>
    <name>A0A167JL23_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_175509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441005">
        <property type="protein sequence ID" value="OAD66217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284257.1">
        <property type="nucleotide sequence ID" value="XM_018437509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JL23"/>
    <dbReference type="GeneID" id="28998415"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175509"/>
    <dbReference type="InParanoid" id="A0A167JL23"/>
    <dbReference type="OrthoDB" id="10406938at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="227" mass="25978" checksum="52384521AE1E7B0B" modified="2016-07-06" version="1">MSLNIFSLLNTGNDLGCNFLATVIDNSRDINLKTDDLELIKENDDKPTWDVNVGLSDKFNKNLASDLMLYICCQPVAAMVSPKELCGIIVNSYYNRLTASKLTEEDRQTNTTSNRRGNRKTALNKRRKKMYTKHKDAITEKFNWDYNGVFYRDAMSGDETETDTSVVASRPGWRSDELNTVFDFLDELARDDLGKRATQLKLRSHVLVHETIPRGLVTKMPTWSKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JVH9</accession>
    <name>A0A167JVH9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_174802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441000">
        <property type="protein sequence ID" value="OAD66776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284816.1">
        <property type="nucleotide sequence ID" value="XM_018437343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JVH9"/>
    <dbReference type="GeneID" id="28998249"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174802"/>
    <dbReference type="InParanoid" id="A0A167JVH9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="266" mass="30770" checksum="EAA2D9C52E9631F4" modified="2016-07-06" version="1">MPNMQLRGEWQKLCWKCQYKKTVAHGHGESVSEKNCVSSLFVVTFMTKFLTFEKKRKLEKKEPVEDQPVEEYDWELLALDTDMMIAVPDAGKNLHGLYRGDSRSLIICNKRKMKEELEANKDKKVRTLADFSFSVPVAPVSPVTEELTVYKQSKDEELEEIREACEKISEMIKPPVSSDSELGKFALFEKIEASEKAAEIFWTTPSKYHEEAVCSWVKEFLQLGKISEHQQGKHAKQSSIVDNENLKRKQSFGFVLKKQKDELLWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K1D3</accession>
    <name>A0A167K1D3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_70410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD67056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285096.1">
        <property type="nucleotide sequence ID" value="XM_018442279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K1D3"/>
    <dbReference type="GeneID" id="29003185"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70410"/>
    <dbReference type="InParanoid" id="A0A167K1D3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="185" mass="21186" checksum="1954D5FB0EF5E288" modified="2016-07-06" version="1">MSSNSILDSYQCIFCKEHDPSLKKAKNCRVQCFKTRHRKHNAIQTFQIIYVPKQVSIVLNTDSNNSIVRENNTTNNDQTVNSFNNSDNDESMYDIEYDNTIEELVAVKDTEDVATPMVYDFSQSLPTPSYDDAKNLKFIQINKDYDISHKAHEKITSHFNGILATSTDITYRVCTSDLGKDPLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KFN4</accession>
    <name>A0A167KFN4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_160329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286029.1">
        <property type="nucleotide sequence ID" value="XM_018434164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KFN4"/>
    <dbReference type="GeneID" id="28995070"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160329"/>
    <dbReference type="InParanoid" id="A0A167KFN4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="61" mass="7232" checksum="1BF8D910AC9BBC67" modified="2016-07-06" version="1">MKAAFTDMRKLFILRVYLLAIIKNLPNVSMAKKPIMYLDNYHCSADKIWFYNLIFASPLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KVU4</accession>
    <name>A0A167KVU4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA mismatch repair protein MSH3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 13">DNA mismatch repair protein MSH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">MutS protein homolog 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHYBLDRAFT_96340</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD69009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287049.1">
        <property type="nucleotide sequence ID" value="XM_018443963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KVU4"/>
    <dbReference type="FunCoup" id="A0A167KVU4">
        <property type="interactions" value="693"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167KVU4"/>
    <dbReference type="GeneID" id="29004868"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_96340"/>
    <dbReference type="InParanoid" id="A0A167KVU4"/>
    <dbReference type="OrthoDB" id="121051at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000004">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF122">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="15">
        <location>
            <begin position="769"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAD69009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="883" mass="99756" checksum="73E3F29DB10E8BF8" modified="2016-07-06" version="1" fragment="single">VKPVLKQSNKILSLKKTDDSIKYTPLESQVVKLKEEYPGVLLAVEVGYKYRFFGEDAVIASRTLRIAHWVDHNFTVASIPVHRLQVHLHRLVDAGYKVGVVCQTETAALKSAGPNKSAPFQRELKQLYTKSTFFDGFGVDQDENGSGPSHSNYLMTIIEENRGKNKTSELVTMAIAVNPATGDVIYDVFEDGFMRSELETRMLHIEPCELLLPFKLSKPTEKIIGMVTSPKTTSPKERARIERIPENETISTDYNTALSFLTEFYAHGNQDNSESGKSAYRVFFVCSKALAATAQYLRQFRLDHSIKLTKYFINFSARGHMLLNGNTMTNLEIYRNSIDNSYKGSLLSILDKTVSPFGKRLLKKWVGRPLINVDQLKIRTDALEELVEADDYLKKDILNFLKHLPDIERDLCRIQYGRSSPKELLGTLEALVKISGALDPRKFRFNSRILTKIIDTLPTARHAQDFKDCLNQNAIGEKNCKHNLFISENQWPDIPMHKQVCGFSTDTHIRAYVIQLKVKLKLVRSQLEEYLEQIKVDVNIPTLRFVDVSGIEYLLEVKNSMASKVPIEWVKMSATKAVSRFHTRFVSEKLKELELSRALLDIAAENAYQDFLRTVSDRYEVFRDVVQSLAELDCLLSLADTALRPDYVRPVFSDHVQIKVKNGRHPMVEQFTTTDYIPNDINFDTDEYRTMILTGPNMGGKSSYIRQVALISIMGQIGSYVPAESAELGILDAVYTRMGAMDNALSGESTFMVELHETSDIMKQATPRSLVILDELGRGTSTHDGMAIAYAVLHRFITKIQSITLFVTHYPSLGGLAKEYPESTTTGHMSFIEEDVNDIPSVIFLYKMVPGISLKSYGLNVARIAGLPKKILAKAKIKSEEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KXW9</accession>
    <name>A0A167KXW9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_66895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287176.1">
        <property type="nucleotide sequence ID" value="XM_018441701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KXW9"/>
    <dbReference type="GeneID" id="29002607"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_66895"/>
    <dbReference type="InParanoid" id="A0A167KXW9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="112" mass="12356" checksum="BDBDD1B55E250A72" modified="2016-07-06" version="1">MIFELQTQCAAHCATCASSRDNTRLLDIACSKNLLGIVSLEILKNSAFGNRLGVKLKFVVNFLKYERIRLSEIVCSTTYCVVCIPCSHTGIETFGAVSPFPLSYAIFMILIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L3P9</accession>
    <name>A0A167L3P9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_182766</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287566.1">
        <property type="nucleotide sequence ID" value="XM_018438670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L3P9"/>
    <dbReference type="STRING" id="763407.A0A167L3P9"/>
    <dbReference type="GeneID" id="28999576"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_182766"/>
    <dbReference type="InParanoid" id="A0A167L3P9"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000049">
        <property type="entry name" value="Cell polarity protein (Tea1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052124">
        <property type="entry name" value="Rab9_kelch_effector"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46647">
        <property type="entry name" value="RAB9 EFFECTOR PROTEIN WITH KELCH MOTIFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46647:SF1">
        <property type="entry name" value="RAB9 EFFECTOR PROTEIN WITH KELCH MOTIFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="385"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="561"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="973"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="776"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="937"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="405"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="497"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="561"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="580"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="611"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="978"/>
            <end position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD69526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="992" mass="111225" checksum="8D313994469DA2E2" modified="2016-07-06" version="1">MAFFAKLTKSSSEKSIYPWSQRKSSSSNNALPRSAHCTIALPNNNILFFNGIHRGPAKRDSFILDSNSLSTSPYNSTGDIPSPRTYPIAQSVGNYVLLHGGEPLQEGDLWDPHLYILNTNNRQWARVRVDGVGPGERAGHSSVVLNGIIYVWGGQRKGKYLDDLYAINMTEYPHNLQWKLISPRNEGPMPRAGHVSVISGNEMYIFGGTDSERLYQDIWTFHLAEQCWSKIPAVGYIPAAREYAACALIDDLIYVFGGKGRDGVKLGDLCAFRIKGYRWYMFQNMGPAPSPRHSLTMTAIKEKIYVVGGEFDGKPEDSLMIHALDSSITTFTAKIKYPPEIIPVRYNTIPSPNLSSPTDQTRGFPQVYPTVSASTHLQSRITPLPATLPVSKSTPLRSVHTRQPHPHEPTMARFVEEQRPPPENRNNPPDQISRFPTWRSYKSPKPALISTTVPEAAIRRARNNSPLTYLDTTHDGNLPSGSYKPSEPAEKEYSLPPTANQSIATYNSQPPSPSTLSIHQNIPQRPPRIASHIGKTPARPSREGINLDTSFQLRSPIIDSPTLQKSSANGSGNIDLWNNALPSHISQQPNPSPRQSLSGAVSDKTQAGSQNEKESQNQSRAEKKKEEEEEDEEQEVSDHSISTKTTEQVPIKLSDLSDPFHNDRVLLLRELRSRDEMIKDMKKKEQWWKAEVTLARKARSSKGDFEDEKCNGDTDLMSIGDKDSKMAKLFNQLVSVKSELRRVRASIVQQALPASQKLEQADRMRIMALQEAAYYRSKYVAMKERQEEELAKIETERAEKLESRLSAALKENQSNSKILQQLQKRAQFDHTARIAAEERVKEAHERAEDAQKAHQAALEKLSDMYTSSLQTEMHLRNSSLRITELTNRLSEALAHRSASDELSEAAITISRLESTNIRTRNETASLKQNLAESMDDIARLRILLSEREEALNEANRQLEDSTIQLNMMKDAMSHGGRISTSDNAHTSTTKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L3R0</accession>
    <name>A0A167L3R0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1206 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_149317</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287567.1">
        <property type="nucleotide sequence ID" value="XM_018432254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L3R0"/>
    <dbReference type="GeneID" id="28993160"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149317"/>
    <dbReference type="InParanoid" id="A0A167L3R0"/>
    <dbReference type="OrthoDB" id="18869at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009597">
        <property type="entry name" value="DUF1206"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06724">
        <property type="entry name" value="DUF1206"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1206" evidence="3">
        <location>
            <begin position="90"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1206" evidence="3">
        <location>
            <begin position="280"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD69527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="480" mass="53752" checksum="3253B6E727C034F1" modified="2016-07-06" version="1">MYNELTYTPLMDHSSPLEILDLQFGAYVNDLFGLKRHPTEDLVQVPKITIPADANLSPRQITIKKYWERFKRPIGVPLNHYTYVKVLGRVGFVSKGIVYAVMGGMCISTAAHLDPEVDGLQSPMGVFIYLGLFSIGTPLLIIMLIGISFYSTWRFWEGSYGQGGDKTQSAFKNFFRCRLSPIVSGCVYIVYLTYIGKLLAKTREERIALGDVTSDDCFPACWGHSEHWYKKAAVVIFGMAFLIACITQLQNVFTKRWHNDLMVHHCTRIEKWVMITLGHLGFLARAGVFMFVGVYMFKVSRHDIEVKHDSFADAINQANNVKGGAVLLWLLGIGLIFFGVFAAGNAYYKYYPTPPPHRQAFYLEDSELHFEPKPKTAEEELTAVIVEIPEATSAKQNTPPMSEIVTPNNNYPSGSSDKNPISIATTETMSISASQTTEDSDVTSIPSPVEESVVSPGAPLMIPERPPSPWESTGRYRMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L5E6</accession>
    <name>A0A167L5E6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Auxilliary activities family 12 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_66143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287677.1">
        <property type="nucleotide sequence ID" value="XM_018441593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L5E6"/>
    <dbReference type="STRING" id="763407.A0A167L5E6"/>
    <dbReference type="GeneID" id="29002499"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_66143"/>
    <dbReference type="InParanoid" id="A0A167L5E6"/>
    <dbReference type="OrthoDB" id="507128at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054539">
        <property type="entry name" value="Beta-prop_PDH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22807">
        <property type="entry name" value="TrAA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007889703" evidence="2">
        <location>
            <begin position="27"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller" evidence="3">
        <location>
            <begin position="83"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD69637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="565" mass="61761" checksum="CF3F6A465BD49631" modified="2016-07-06" version="1">MPIGNRFYAAAYLLSIASLFSASVFAVDDASDVAFKKLGGLHMESTNALVPDASSEHPLVISHPEDQPVCNPNVVIEPSHKFKTLQGYEAIVLTNAIPKPRKLILDHADHLLAVSGTNSLYSIRMDECGNPNVMLLIDQSSIGNQIFAHGLAQYADHIYVTTPSSVWQFNYVDGQHTPLTGGIKVLDNINIDDDSAQPDIAIDPFGYAYIPRTVTELHENVEPGHAIIKRFNFRQIPEGGYDFDNDGQVHAIGANSHGSMSFDAQARLWGIEAPLGTVDRSDMGGDITEKGLAGEINLYEFPMENYGFPYCFTEYDLSSYTANGLGKGTQWGHPMFMNETMDLDSYCQTLDNSQQPAFPLTSSSNAIAVNFYMGESCSVGDLESMGTSVGMPCNWTDTPIVAYHGQEGGPEGHSVVHLGMDDLGHRPRWDKREEIIFEAAEPCSSDDLPCISPVGLAVDSFGRLFISSDDSNEIFRVNRIYNPKAAQELTDKDNAKEAAADAAADAKEDAEMEAKEQAQEKAEQDAAEAVDTAKEKKDESLENDSEDQDSEKTQKSQKISKMSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L846</accession>
    <name>A0A167L846_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_70553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287838.1">
        <property type="nucleotide sequence ID" value="XM_018442297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L846"/>
    <dbReference type="STRING" id="763407.A0A167L846"/>
    <dbReference type="GeneID" id="29003203"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70553"/>
    <dbReference type="InParanoid" id="A0A167L846"/>
    <dbReference type="OrthoDB" id="2283219at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="31"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="117" mass="13483" checksum="F57477680D8615E6" modified="2016-07-06" version="1">MICSCFWTGGFGPLALLEGNVNQEVYVDTLSQKFVPWVKNLSEQHQKDFKLQEDGASCHTGAYAKWWKETHEIKGFEYWSAQSLDLNPIEHVWWALEVKLSKVRASIQNVNELKIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MU12</accession>
    <name>A0A167MU12_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_145443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292019.1">
        <property type="nucleotide sequence ID" value="XM_018431442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MU12"/>
    <dbReference type="GeneID" id="28992348"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145443"/>
    <dbReference type="InParanoid" id="A0A167MU12"/>
    <dbReference type="OrthoDB" id="2270049at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="169" mass="18897" checksum="AD2481593FCBE9A4" modified="2016-07-06" version="1">MVAYWYSTDGIDQRRLSNRHLSILDEAFKQQRRVEIYDEDAFGPEVLATACPHLGTMTAGLLHYGLYRQPSLWDACDSSLETLLLMDCGDGADQDSKGLSSDWYENSCGLLDTPAIEIPDSVHSPDHHAMMRTIPQGTNPSSLFSNYQSVPDRPQSHLHDSSYICCIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MUQ3</accession>
    <name>A0A167MUQ3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_102239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD74054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292094.1">
        <property type="nucleotide sequence ID" value="XM_018427694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MUQ3"/>
    <dbReference type="GeneID" id="28988600"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_102239"/>
    <dbReference type="InParanoid" id="A0A167MUQ3"/>
    <dbReference type="OrthoDB" id="3039677at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="177" mass="20015" checksum="E4FB6B1811AFA152" modified="2016-07-06" version="1" fragment="single">NLPHDKRFKPENIILVGLMPGPKELKTDEINGYLKPLIDDLKQLYVGMRIPTHEFPNGVCVRAALLMVACDIPVARKTSGFTAHNSTCACYRCSWQFTGLESSNQIDFCGFDYSRWNICSGAESRLHAEEWKDASTLSERHQLEIENGAQCLQLQRLGYFDLVRGTIIDPIHNLFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MWT4</accession>
    <name>A0A167MWT4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_167735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292359.1">
        <property type="nucleotide sequence ID" value="XM_018435705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MWT4"/>
    <dbReference type="STRING" id="763407.A0A167MWT4"/>
    <dbReference type="GeneID" id="28996611"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167735"/>
    <dbReference type="InParanoid" id="A0A167MWT4"/>
    <dbReference type="OrthoDB" id="2404451at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD74319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="795" mass="90513" checksum="569602DE23F52E2F" modified="2016-07-06" version="1">MSSSNASQQRDRIFTQQYQCDQCVLFFDNYQKLQNHKRIHRGDSATMTEIDQSILDDVDMYHDENDTSNEDESVSNSEYTMESMELDNTISYKCACNFEDSEGEAHIYNSSQISTNTSTKAELMSIHLSQLMLQHRIARAAYRDIVQFINTVIRDHDNIMMEPGGKISHGETVDALLKSKSSVKDHEYDVCSSGCRLYGINDDQESCVDCSKPRYKTDPDQGQTPAASMKLMSVGDMLSQMLADPATRELLCYRANRESVAGQLTNIFDGDNYKQLVQQGLFSNPDDIVIGLYTDGFVNQKKGKNSYTIIHCIIFNLDLSIRWHGMYFDDISARLRPLEDFKVGNPSKNIYQPSIYTQLSTFSGSSFFALDELHLIARGIGKLVYDLITITLTKETKFYYTHPDNTLNITEYPFHIPRADLVTIGNCITSSRKYIPTSFQGSFDNVFAKIDGTRTVDWLDFLLYLVPTLVVPYLPNRAVKTALLSLMKGCALALQWTLTSELLDEMQSTGTRFYINKSRIVLCLVVFSDQCNITWSIYPISSSSKAPCNATPLAQWRDTAISICDEINLIRPKPYGRESYMDLPNDPSGVQLWEPFHQFVNLNNDSVEGVGSPSVKEALLKYYQRTTGLTGHEFGDSVVVVAARLWMDSTVYSSCMYRRKKNETSRGNHYVMFTCPYRNNRNVIVYSWLIGTVQFYFQHVDFYGFPHFLAFMEIMKEHDAAGHDSSVPIIKQRSQSTRILGHQTQPTYAVISVNDICHQVGLIQYPLNGNQFYVIAPYYIFNNNMRITKGNLSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MYG0</accession>
    <name>A0A167MYG0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHYBLDRAFT_97237</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292554.1">
        <property type="nucleotide sequence ID" value="XM_018444015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MYG0"/>
    <dbReference type="FunCoup" id="A0A167MYG0">
        <property type="interactions" value="809"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167MYG0"/>
    <dbReference type="GeneID" id="29004920"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_97237"/>
    <dbReference type="InParanoid" id="A0A167MYG0"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17967">
        <property type="entry name" value="DEADc_DDX3_DDX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000160">
        <property type="entry name" value="ATP-dependent RNA helicase DDX3X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044763">
        <property type="entry name" value="Ded1/Dbp1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="93"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="295"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="456"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAD74514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="488" mass="54475" checksum="E8C12A27829D2FD4" modified="2016-07-06" version="1" fragment="single">RDEGQGYWKDGVHHIGARNPRTERELYGVVEDVDRQHTGINFEKYDDIPVEASGNDCPEPVTQFTSPPLDSHLLTNIEFARYTTPTPVQKYSIPIVGNGRDLMACAQTGSGKTGGFLFPVLSELFLKGPMEIPAEDPSRGYRSRKAYPSVLILAPTRELVSQIFEEAKKFAYRSWVRPAVAYGGADIGSQLRQIERGCDLLVATPGRLVDLIERARISLANIRYLVLDEADRMLDMGFEPQIRRIVEKEDMPDVEERVTLMFSATFPRDIQYLARDFLKDYVFLSVGRVGSTSENITQKIMYVEDEDKRSAILDILHSTEVPGLTLIFVETKRMADTLSEFLLDHNFPATSIHGDRTQRERERALDSFRSGRTPVMVATAVAARGLDIANVSHVISYDLPTDIDDYVHRIGRTGRAGNTGLATAFFNRGNKNIVNDLVDILKEANQEMPSFLESISRESRSFGGGRGGRGGSRGGRGGSFGGRDFRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N7I0</accession>
    <name>A0A167N7I0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_180724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293270.1">
        <property type="nucleotide sequence ID" value="XM_018438355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N7I0"/>
    <dbReference type="GeneID" id="28999261"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_180724"/>
    <dbReference type="InParanoid" id="A0A167N7I0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="199" mass="22386" checksum="D071A8B7F7ED72A5" modified="2016-07-06" version="1">MSMPTRIARMKKARASKEIDYLHNNINVIDLSCSLITTRSCEITRLHKGDSATVAGVAYYISKDTEMELDIDDSTVDNESIRDSEHTMDAMDVGEVVSYKYGCTFKNREGEAHHKIARAAYRDIVRFVNTIIWDHDEIMLVTVLMSYISPGPESVMVKQLMLCLSKSSIKGHEYDVCPSGCRLYGINDDQESCVDCGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N9Z5</accession>
    <name>A0A167N9Z5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="9">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_30672</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 9">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="9"/>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293484.1">
        <property type="nucleotide sequence ID" value="XM_018439968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N9Z5"/>
    <dbReference type="FunCoup" id="A0A167N9Z5">
        <property type="interactions" value="422"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167N9Z5"/>
    <dbReference type="GeneID" id="29000874"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_30672"/>
    <dbReference type="InParanoid" id="A0A167N9Z5"/>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000365">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017751">
        <property type="entry name" value="G3P_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03376">
        <property type="entry name" value="glycerol3P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="11">
        <location>
            <begin position="194"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="270"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD75444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="343" mass="37547" checksum="184C4A7DE7CB0A7D" modified="2016-07-06" version="1">MSLEHVCIIGSGNWGSAIAKIIGNNVHKYPQQFSPTVRQWVFEEMIDGKKLTDIINNDHENVKYLKGVPLPVNVVAVPDLVDACKDATLVIFVLPHQFVRGICEKMKGSLSPGARAISLIKGLEITPSGTRLFSEEISRILDIPCAALSGANIADEVARERFCESTIGCESVEDGQVWHRVFHTDYFRINVIKDYTGVQLCGALKNIVAVGAGFSDGLGLGSNTKAAIIRLGLMEMRKFGQTFFGDMVQNETFFESCGTADLITTCSGGRNRKVAEAFVKTGKPIAQLETELLNGQKLQGTLTAQEVHEFLTGKDMVPEFPLFDTVYRIVYEGASPEAIVRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NBS5</accession>
    <name>A0A167NBS5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_180848</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293659.1">
        <property type="nucleotide sequence ID" value="XM_018438369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NBS5"/>
    <dbReference type="FunCoup" id="A0A167NBS5">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167NBS5"/>
    <dbReference type="GeneID" id="28999275"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_180848"/>
    <dbReference type="InParanoid" id="A0A167NBS5"/>
    <dbReference type="OrthoDB" id="361494at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000109">
        <property type="term" value="C:nucleotide-excision repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042238">
        <property type="entry name" value="Rad28/ERCC8/Ckn1/ATCSA-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202:SF1">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="75"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="161"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="218"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD75619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="438" mass="48491" checksum="2CF42EA04CA26531" modified="2016-07-06" version="1">MYSLLRKRGTGAVDPLILKRAETTQKAHKVELSQTKEFKRVHHVSGGGDGLLHVYDLQQEGRPAQIEPIASVATQDRHSYAVSSVGWFPFDTGILVSASFDETVRIWDTNLMEPVTTFDLGAKVFCQAMSPIASHCLVATASDNPHIRLCDIKSGASAHTLIGHTGSVYCCVWSNYQDHVLYTGGEDGTIRVWDIRKASACLGSLDNENAEFTKIETNRAHQKAVNGLVLTLDGSSLVSLGLDERIKRWSTYDHRHSRTHYAGSGVRNHVRHNCGLAVSDTDVWPPLVYVPNQDHIAVFDVNRGNRVQKLCGMYGRPTCVDVEGLDVYAAGVEAEILVWGPLPPFDSEPGIEETTVYEVVLDRHGVAQRVPKGKGTHFIHVTKHNETKMVEKADSGSFPCPEPTFQAPMRWSQRIHPKQPEQAELNPTLHEKEAVSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NCJ5</accession>
    <name>A0A167NCJ5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_143916</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293708.1">
        <property type="nucleotide sequence ID" value="XM_018431097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NCJ5"/>
    <dbReference type="STRING" id="763407.A0A167NCJ5"/>
    <dbReference type="GeneID" id="28992003"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143916"/>
    <dbReference type="InParanoid" id="A0A167NCJ5"/>
    <dbReference type="OrthoDB" id="2276543at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="119"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD75668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="290" mass="33372" checksum="3CA9D749698D3031" modified="2016-07-06" version="1">MPRISDRKSILTSLKKRIYTNLVQHVVCDDLLMQNIVENISELFIFQLVSEQRYLSPRLDIPRAPSQMMMTLGRLGKYGTGASVGYVARSFGVSDENERVLISQRIEEQTDFPSCIGFVDGTLIRLEYKPNWDGKDFYNRKSIYCLSAMTVCDDKKRVHHCFTGWPGCSHNARVYVSSQLALSPEAHFSNDQYLLGDSAYIPSMEVVPGFESLKGLHTSVYNKYDIEKIGYWIRCCYVLHNLLLDCGDDTFVEDSVRNTDTPRNDERLEPRTSSQLDKNKRERIKQIIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NTY6</accession>
    <name>A0A167NTY6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_157953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294638.1">
        <property type="nucleotide sequence ID" value="XM_018433703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NTY6"/>
    <dbReference type="GeneID" id="28994609"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157953"/>
    <dbReference type="InParanoid" id="A0A167NTY6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="148" mass="13461" checksum="09B5EF9CCD599854" modified="2016-07-06" version="1">MACACVGPDTVRAGELAGELTGPVDVGRGVAVDTTIGADVADDTTDADTDTDDDDDDGAAVVGTICAAVVVPSDVVVADDTIVVADIVAGIVAVVSAAAVGTDVAAGVGTGAGTGTGAGTDAGACAGACDGTCVGACVGACVGACVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NWQ2</accession>
    <name>A0A167NWQ2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_185845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294811.1">
        <property type="nucleotide sequence ID" value="XM_018439155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NWQ2"/>
    <dbReference type="STRING" id="763407.A0A167NWQ2"/>
    <dbReference type="GeneID" id="29000061"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_185845"/>
    <dbReference type="InParanoid" id="A0A167NWQ2"/>
    <dbReference type="OrthoDB" id="5599552at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF18">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="6">
        <location>
            <begin position="36"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="313"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="410"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="571"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="350"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="571"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD76771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="629" mass="70183" checksum="C99C97B3AB25796A" modified="2016-07-06" version="1">MAMLEKPISEIVDGQAIQSTSSCTYRFIPSTCSYLAEQRNYQLIMRQEPQRAKMSVINERDRRPIEPPPILQLNWLNCSTEETKKYLQSPFYFMVANLMKANDTTKALDSHEYLSGSTVSSLYRLRDVDNTDGGFFVFGDLAVKKDGYYRLQFNLFEIMDGTVQNRKTMLSEVFVVHLPKKFPGAIEATFLSRTFSDQGVKMRIRKEHRLQTRKRKAERQIDSDMADVKRVVVTDQEPISGQRTSCQNEVLFGRWQSNVGVTSRSLGQTGPIETIHQASSMSAVNPFNPGGEGRLRYKDLTSRFRYYPKQHENKGFYEPMDTSNSISTSTSTSTNTSISLSNSLSSSTIGTPNSPSGDIGGNTNDGEPLAQDTSEFPSPISRTHSVTSEAPEQLSWSPASNDMMKIERLASHGCGSPSSGGAWHLTNNSSSNSNSNSDSYQDTPDLFHNSSNSPPSPTPTAYTVQSPPTLIHQAPSSEAHLASYHFTASDRRPTQSYASEDTHPLSHIHYAATKNEHWGERLPPLRAIMEDQHTDQHSLHTHVAPLELPAIITSGNPHRLGADSSSSSFLPTLFPSYVPQSNQQPKKQHQHQYQHNHTHNHNHHNHQSRQTPHSMSGQDVGGIFAQCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NXG5</accession>
    <name>A0A167NXG5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_142322</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294861.1">
        <property type="nucleotide sequence ID" value="XM_018430780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NXG5"/>
    <dbReference type="FunCoup" id="A0A167NXG5">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="GeneID" id="28991686"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_142322"/>
    <dbReference type="InParanoid" id="A0A167NXG5"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="498"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="544"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="592"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="637"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="686"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="711"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="745"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="774"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="107"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="275"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="496"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="818"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="965"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1013"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="818"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="966"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="979"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1053"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1092"/>
            <end position="1107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD76821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1122" mass="124617" checksum="70548253CA995291" modified="2016-07-06" version="1">MDTISSVLGPTPTGSFVSLTSNLLSGTMGSSGSIPTAASSLLSNAIPSAVLSISSTESALPSSTAAPDAAETSSSGFDGIIPGFNGSQVTGPLSVVGSVDKQSGLDTQLLISSSVGLFCFLVFCILRTRIPVIFAPRMNMKKHRPPELPSSLFGWVIPLIRISQEQLLDNVGLDAVVLIQFLVMGIKLFGLCSFFGLTVLIPISMKTGNSTNPNITAVNRLSITVIDESSNSLIAYLVFTYIFTFFTFYFLQQNYDSHIYLRAKYLIRLSKTLTARSVIVTGIPEKLRSDHELADYFEHLNIGPVESCYVVRHISHLNKLLKKRLSALKHLERAYATYWGNPCKIPEYDPDLVLEDAKMLKRVEKLTQQAIEHEENSSNTAIIMNLIDPKKRGTQSHRPQVKTGFLGLFGEKVDAIEYYTKMFDELDKRVVEARQSTDFEMTNVGFVTFKNMASALIVSQIAISPTPFVCRTVMAYEPRDVLWNNVTIRGRERLVREVVVWTITIALAIFWVIPIAALASLTSIDFLERLSPSLAEKAKSSALLLNLLQGVIPTLLVNIFMAILPLIIDLLGKLQGIRARSALAETTFSKYFFFLLFNVLLVFAVVNTVTSTLVSFFNNPKDIVNVLGEKLPAVSPFFINYTILQGFLLMPLNLLLLGPLIVRGFKEFFICKSPRDYARNRVPSSFNYGVQFPAPLLIFIIVLVYSTISPLILVFGTIYFCITYFVYKYRFLYVHFTPYESSGKLWVMVFPRVIIGLLLFQLTVLGIFILKKFFVLAILCVPLMVITVLFKIMIDSAYLENSRYLPMQLLRDNVMQLPTSDQTSSNKSASTPLSEATQNSSDATNINRKRWKKATAAALLINTQNTSFATLNEPTSVHHRRVALDEDDYEAVPDRKTDYRQPPVTLNPGVLDTGLKHFGNPALKGVLPQLWLPIKLNRAGQPATRPPPHKRFGGSHLATNLAQMLRRAESAKRKESEKATNSGSNPSLDVSGEKGAMAADRFLKTSGPLRARFEKSQGKFQDSTDILADEPSKYSRRSSRVPMAAADTHSLDEQYDDNDDDDDNYSDISDVQKGPHATYYHHPSQRRHSLGNLVTPQRPNINPQNGDSAPAVFCSTQSPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NXH3</accession>
    <name>A0A167NXH3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="14">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_9438</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the creA/MIG C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294864.1">
        <property type="nucleotide sequence ID" value="XM_018443860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NXH3"/>
    <dbReference type="STRING" id="763407.A0A167NXH3"/>
    <dbReference type="GeneID" id="29004765"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_9438"/>
    <dbReference type="InParanoid" id="A0A167NXH3"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000433">
        <property type="term" value="P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000089">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000152">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF1">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD76824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="65" mass="7896" checksum="78D5B3D1DA9E24B1" modified="2016-07-06" version="1" fragment="single">RPYKCPMCPKSFYRLEHQTRHIRTHTGEKPHSCTFPGCEKRFSRSDELTRHVRIHAAPHRKRDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NXP4</accession>
    <name>A0A167NXP4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_142337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294874.1">
        <property type="nucleotide sequence ID" value="XM_018430784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NXP4"/>
    <dbReference type="GeneID" id="28991690"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_142337"/>
    <dbReference type="InParanoid" id="A0A167NXP4"/>
    <dbReference type="OrthoDB" id="2431110at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="133" mass="15513" checksum="1AD299C8A5E78452" modified="2016-07-06" version="1">MHNLFLATVKRIVQIWKELEYFDNQALLAMQDLANGVVVPPDYARINKKIADGFSFMKDDEWKSWCLIYSPFVLKRILPVKHLSNWIAHAHLQSFCKGFEKLYKEFPVTPNMHLHLHLGECINDFGPISVTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NYK0</accession>
    <name>A0A167NYK0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_142391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294926.1">
        <property type="nucleotide sequence ID" value="XM_018430803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NYK0"/>
    <dbReference type="GeneID" id="28991709"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_142391"/>
    <dbReference type="InParanoid" id="A0A167NYK0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="58" mass="6571" checksum="FBDDA51584D2B26A" modified="2016-07-06" version="1">MNNSTGRDGVQEATTAIFGLPPPKIKEYITRLMREQQPRDTINKMNTILDNLPNLVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PEY5</accession>
    <name>A0A167PEY5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_76505</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295826.1">
        <property type="nucleotide sequence ID" value="XM_018443163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PEY5"/>
    <dbReference type="STRING" id="763407.A0A167PEY5"/>
    <dbReference type="GeneID" id="29004069"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_76505"/>
    <dbReference type="InParanoid" id="A0A167PEY5"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="4"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="8">
        <location>
            <begin position="781"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="687"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="689"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD77786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="904" mass="99841" checksum="7B12C6A91D24A976" modified="2016-07-06" version="1">MEESEVLIIGAGPVGLYTALLLSRMGISVRIIDKADNLNTTNPAILWSPRSVQLFQSLGIANQIINQGVKHWRFYAFKNKGHGSTAVSFEPYNYRVWDNSSTEYDWCLSCECSQICAILQNTLLDQGIRVEYGHELVDFEDENSDNTTTSASPLNSSFIDPSRQSFGFANESRQSFGSSREEEVVKVMSTIRDVQTGKVHDWRSRIIIGADGTKGFVRQKLGLAQRGKDLHMKFYTLEASVTTNYPGTRTMSTVNKGEYMIMVVGHRDRMYFIVEHLESWSHLPIDENALLTSAQQHIRSIMEPYQIDFGHVYSYSSWRAGDKASEEVSIDQRYFLLGGAAQQVSPPCLFSANPGLEHATNLSWKLFLHLRKRASPELLETFNSEFKSKHNDTVEASYASMSLIASRIMPGLISGLNSTRRQEASYQMQRNENQLMGESSYEHNLINHGSESTLSLGAASIDTMDIMDIMLAMATSKMGSNEPKTGAVGSLAPDAKLKPYTLLQLFSQTQTQTSEATKMMESTKNSATGLIASASTSAGTGVADVSVAAGAQPRRSRSQSNASTATTWSFNRVGPMLKKAMGTHSLVKCSSRPSDENDVLTACPMTTSSGVERWKSIKTNNYQLRERIVTKGIPVTFTVLVFCGSLADQENVSMLRSLKRRIDDPNSFFNCYENSPHVYQTLVEENTTVQPVSPQSPPSVSDVESGHSNENSRSSFSSISSQRSSTSSRSARSLSKITSIVTNSLPPATIPPTSPTSSLLSPVSSLQIGPWSTSFEQPRTSLTSTINNDSSADKPHQLFNFIYITTSTKNQVSKFLTETPPSVLHNTFPCGLSNVYLDHDQQCHTAYSIPKPTIVVVRPDGYIGTRVKINEHNDINKLNNYFDAFLRPPADMTSAAAVVAEDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PG50</accession>
    <name>A0A167PG50_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_141712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295888.1">
        <property type="nucleotide sequence ID" value="XM_018430648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PG50"/>
    <dbReference type="GeneID" id="28991554"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141712"/>
    <dbReference type="InParanoid" id="A0A167PG50"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD77848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="305" mass="34879" checksum="A0D8B19AAA0A5F72" modified="2016-07-06" version="1">MTTIFTAQAKQQGSKLKFGLQFKYQGSDLKSRLLVHTFFSVFTCFLSYWPNVSTIRLHNEEFVFLPVQQSKPAIMNQISVHVLAVNGNEQGPIKFNAHGSGFHKAEELGLDIHPDLQIYIFLWAIVYWLFYLSIVFTVKENHQGSDLHPCFHRPNRRTKISSASTVTVYSQERPTIKMPLSFLDFGSLFTIEAITQDFIVHAGLQSRLLIEIPLLIWVHADYQYSAIRRGHTKDQDFSLHPGSQTFKPRDKLSNLNNEPQCFKSDSNDQASNFHSLIKFSVFIMFPLNILGVMVNDQDPAINPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PMB7</accession>
    <name>A0A167PMB7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_107449</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296248.1">
        <property type="nucleotide sequence ID" value="XM_018427997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PMB7"/>
    <dbReference type="STRING" id="763407.A0A167PMB7"/>
    <dbReference type="GeneID" id="28988903"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_107449"/>
    <dbReference type="InParanoid" id="A0A167PMB7"/>
    <dbReference type="OrthoDB" id="2289269at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF0">
        <property type="entry name" value="SEC2P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="17"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD78208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="116" mass="13421" checksum="5B26E34F6F7C932B" modified="2016-07-06" version="1" fragment="single">MTIRELSTAANDLSQSVQVKSQELTALRSDMAKLNEKYIGQVDKVIELQLAKDAVESELEELSRKLFEEANGMVANEKREKHKIEVAYEHLRKQLTETQERLSTEELQLNELRTMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q3K8</accession>
    <name>A0A167Q3K8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_62215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD79016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297056.1">
        <property type="nucleotide sequence ID" value="XM_018440933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q3K8"/>
    <dbReference type="STRING" id="763407.A0A167Q3K8"/>
    <dbReference type="GeneID" id="29001839"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_62215"/>
    <dbReference type="InParanoid" id="A0A167Q3K8"/>
    <dbReference type="OrthoDB" id="2285175at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD79016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19695" checksum="738BA061A89F69D8" modified="2016-07-06" version="1">MQVLIQACRPVLGVDPILFLPASRMERGRLIRWRMGWLPGKTKECPCGSDHTSRRHLLDCPLVPVALFEQLPQPDQDQIHRIDFAITSLPLSSQEPRPAYWIPLLTILWHIDIICNPDGDYSHETEHDFKKLNITSFSITIQTINTNATAQYTEFNAAKGGYEFAIFSDYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q7W4</accession>
    <name>A0A167Q7W4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cold-shock transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_139274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297278.1">
        <property type="nucleotide sequence ID" value="XM_018430193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q7W4"/>
    <dbReference type="STRING" id="763407.A0A167Q7W4"/>
    <dbReference type="GeneID" id="28991099"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139274"/>
    <dbReference type="InParanoid" id="A0A167Q7W4"/>
    <dbReference type="OrthoDB" id="422005at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050181">
        <property type="entry name" value="Cold_shock_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11544">
        <property type="entry name" value="COLD SHOCK DOMAIN CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="1">
        <location>
            <begin position="4"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="208" mass="23028" checksum="BDC659AAB59CC8B4" modified="2016-07-06" version="1">MSSRQTGIVKFFNSAKGYGFIIPNSPINQSKIEEVFVHHTAIHNDGGFKSLKEGEEVEYDLIEGPKGFQAANVSGPEGIPVQGDPFASLNQNRGQYKDEDKAQSYWVGYNNNYYLPVHGVYSYGPSYVPYGQQPMYIIRSTGTPIVSPPSSSSNSIVPSQLATASWPRYQTMPTPEKTPYHAVYAYYYPRPVASRSPPLTHSESTSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q9U0</accession>
    <name>A0A167Q9U0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_157220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297378.1">
        <property type="nucleotide sequence ID" value="XM_018433586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q9U0"/>
    <dbReference type="STRING" id="763407.A0A167Q9U0"/>
    <dbReference type="GeneID" id="28994492"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157220"/>
    <dbReference type="InParanoid" id="A0A167Q9U0"/>
    <dbReference type="OrthoDB" id="2231705at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="172" mass="20165" checksum="DE814B4A17B685C1" modified="2016-07-06" version="1">MTGVTDEYGDKAKFSLPKNTVTIDELEKQIEYMDKIIFAAINKRVLRINEELKKKYNHKNILIDIPKGAHVMVRLPHRPNKLAPIYEGPYTVVRRNKGELYELKDEQGELLHQNYTPSELKMVTIDESTIENELYEVEDIRDHHGAAGEREYQSHNNTKVLEEGQRNRTFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QSX2</accession>
    <name>A0A167QSX2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_140208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298244.1">
        <property type="nucleotide sequence ID" value="XM_018430348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QSX2"/>
    <dbReference type="STRING" id="763407.A0A167QSX2"/>
    <dbReference type="GeneID" id="28991254"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_140208"/>
    <dbReference type="InParanoid" id="A0A167QSX2"/>
    <dbReference type="OrthoDB" id="2289822at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="432" mass="48226" checksum="7EB7E9766395955C" modified="2016-07-06" version="1">MSTGDTPAVSDLMNLMHHNAQYGCRHCFVHGESIARTMCFLESEGPAPMRDIGSIRRAEGSRPGGGRYNVFAELPILTSSAFFGQNEMHLLDHGTGHQLYQALGGKFCSGTVNEGIERQEEGHQLMDFLLFVVPTVIIDHLCFADAKQAVRDLVLACSIVQQWSITASDIVAVEQCKISDGKLKSNIFVMNQHMLVHLGFMLWKMGPLQAYSCRPIERTIGAYTSAIKSRKEPGKNMENVFFQMVAISYCHGNRPARTGPADRRTSNFEVASDDVAGPQLWSSPTRYSMAKLANTIGMEWEDLVQQLLPFWAGEGVSSFEKQDLVVYRVQSSFDSRHVRANNLVVLKHMWDYGFVCKFFSHTVKGVTRLFAATESVSDVRPLPGMLFPVSSNRSQGEMRIVDMKSFKEMAGLVHNTKDGAIRHIVWPSPTHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QT02</accession>
    <name>A0A167QT02_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_140215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298254.1">
        <property type="nucleotide sequence ID" value="XM_018430353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QT02"/>
    <dbReference type="GeneID" id="28991259"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_140215"/>
    <dbReference type="InParanoid" id="A0A167QT02"/>
    <dbReference type="OrthoDB" id="2262863at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF34">
        <property type="entry name" value="NOTOCHORD-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD80214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1002" mass="114371" checksum="4A6BEB19E37DB9D6" modified="2016-07-06" version="1">MQKNTRQETYKIVKTCPPKRQGELNFSINSGVFTCSECEKEFEKPWLLKRHSKVHHISNQMATNTVLDEPEQAELIVENTIPDANAFDYSSDEDDSSSIGDEEDNIVDEENDIVDNFFDIEMNSNPVFNAFSDMFSSAAAADEVSMTDDDSEILEEVFETIGAVNDPTSCYPFRDLQTMILFAFIDGDNDMISQQMLKKILLAMNLIIKIQQETPIGRTFKLPRLDALLNYQARKKSKMPVFPSQRISVPGSNGNAFAHINLPSDHLRFLMANPKKSKLISSMPDRTPNQSICLEQGEKWRTHHLFQQPMHTVNGIDVWFGNIVYLKTNDCSIRFLVKSFHTANKNIFARGYLVRAISIVCYGVEVAVTDLRVEQISHVDTTPVERDHYYSISSSLTRLSPAHDFLLFGVHPMKKPMPLSVLPGNVDRDAVFYKVRIVSIILFTDDTSGNRSKQYNPFESWLMRCTALPFKDRNSIANIQFLSTIPKKDGANGMSLLPAIVDDFKKLEKGVKMFSTEDNEYVLVVAPILWIEADTPCHSELCGLLGPATTFPCRRCYIELRRAKDFVKDLFYFCECHERRTREHYVLANSSPGRDTEIPNAPKIGMNTPANEISFRDRSTGRLLELQSFDPEKDTPVEILHTILLGVAKYMVIDLVKVVLKNDTATIARLSEFLTDYMRSTGLSRKFTRNLRHSGSFLGRDFKVLLQILSVILITEFSGNHELDLVIPCFVELGRLCSLVFVRQVTSDFDNYIIRVDNAVKRLIRALFDYDKGTKNELHKAYCTKPKVHYLTHLKEDIIRFGPALNYETEKGEQFNKHIREHLFHTNRQNTSRDVCLKFAKQVALQHVIDGGSWINSSGNREKSGTGIERFIKDNNESLFYYTFFGGSRELKDNNDTGDIEDDAVQNNSFGVFVFKDDPISRPRIGLVSGSVVKFLSIVPRTDNDRNNNYAKAVMTGEHSDVANMNLVCKLDLHIFRNPFYIVNLSKFGSYWFIFNNILFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R0V9</accession>
    <name>A0A167R0V9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Palmitoyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_104666</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palmitoyl-protein thioesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298628.1">
        <property type="nucleotide sequence ID" value="XM_018427858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R0V9"/>
    <dbReference type="STRING" id="763407.A0A167R0V9"/>
    <dbReference type="GeneID" id="28988764"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_104666"/>
    <dbReference type="InParanoid" id="A0A167R0V9"/>
    <dbReference type="OrthoDB" id="10263094at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000107">
        <property type="entry name" value="Palmitoyl-protein thioesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002472">
        <property type="entry name" value="Palm_thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF8">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00414">
        <property type="entry name" value="PPTHIESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD80588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="282" mass="32263" checksum="F7462603F4C5B472" modified="2016-07-06" version="1" fragment="single">VVLWHGMGDDCCNEESMGRVKTLVSNSLPGVFVHSVQVGDTPKEDHNAGFFGVLKDQVDHVCRQLKDIPELSNGFNAIGFSQGGLFLRAYVEHCNRPSVHRLITFGSPHGGVSDIPNCTDPRDFSCALMRSIVRRGVYTDYVQHRIIQAQYYKNPKDLKGYLKKNIFLPDLNNELGTQNSTYRDHLSSLDMFVMIRFEEDAMIKPAETAWFWTQDSKGALVRLEDQLLYRQDWLGLQRLGNEGRLVFLVCPGQHMKITDAYFEEKVIRPYLAEEPLRLLDQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R769</accession>
    <name>A0A167R769_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable lysosomal cobalamin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_76922</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family. LMBRD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299049.1">
        <property type="nucleotide sequence ID" value="XM_018443201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R769"/>
    <dbReference type="STRING" id="763407.A0A167R769"/>
    <dbReference type="GeneID" id="29004107"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_76922"/>
    <dbReference type="InParanoid" id="A0A167R769"/>
    <dbReference type="OrthoDB" id="73273at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072665">
        <property type="term" value="P:protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050854">
        <property type="entry name" value="LMBD1_LysCbl_Transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130:SF2">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORT ESCORT PROTEIN LMBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="85"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="251"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD81009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="538" mass="60969" checksum="13D545B5EB5CAE42" modified="2016-07-06" version="1">MPAAVGLAWMTFGMVSVGLYLFSAGFINYYHDKHHSRVAVTLVSVLSVGLSLCLLALLPVDVFLVSLTVDHQTGLKQEWADEDTVYWITMATFIVYYGCHALIGLLLFFVLPFAYFYYKKYDEDQDRRQRALTGIRYTVGFGILASVLFMIGLFGRPTQLPVQLELEWFLNLINESHGEKAISFVMACPQLLGMFIFVAYTAPGLSILPFKFLKDRGRVDTEYEDITARLASNIEQQRKIEHHPTSSRSTHSEQERTLHNLIDEAKIFERQLKDLEDDRNKWRYKLWLMFRPFELAFGIFLLVVSFLIVLCIILSCFDKMVFSICGSECGYIASSPDFFQPINFILVNIQRAFPLDYMLLVGLIVYLLVVTMVGIDSLGLKFLWVTLYRVERKATGAQALVISSTLLTLGLLAANYSIVSFIAPAYAHFGSQVYCNSEEGDVRDCSLDVDLIVPCDIYGPTDICTPTVISTSIDRISFNSPRVSAVYYYSHWVFVVTYVAGFVMSLVRKPPKDIGEEEGLLDRTGKKAYQTISDQITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N8P2</accession>
    <name>A0A162N8P2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_169707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290619.1">
        <property type="nucleotide sequence ID" value="XM_018436139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N8P2"/>
    <dbReference type="GeneID" id="28997045"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169707"/>
    <dbReference type="InParanoid" id="A0A162N8P2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="205" mass="23442" checksum="CA7A5A28C7FFDD22" modified="2016-07-06" version="1">MALVSIKAYRHTRFFLLEYVLTISFNLSKSSQLMSTVTVLTYISNHSHRHTSLFEPLVTLSCIFPYFLRQRSAIKVSLSIKILSLFTTRANDQYSAAHFGLYSFNRQVQNLWLCSTSWAVVGVKDHCLTLIHMLQLIPGISILLSIVGHSYICLFSFVFFHLSFFTISTAKSNAKKLSLYQGLQTSPIIKISGSHIIYLHMYLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NAV5</accession>
    <name>A0A162NAV5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_168961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290738.1">
        <property type="nucleotide sequence ID" value="XM_018435978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NAV5"/>
    <dbReference type="GeneID" id="28996884"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168961"/>
    <dbReference type="InParanoid" id="A0A162NAV5"/>
    <dbReference type="OrthoDB" id="2299058at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="34723" checksum="C4F66FA1A4170A7F" modified="2016-07-06" version="1">MSNQNESYPTRRTPAEREMTNSLAILRRDMTTVMKDVADIKAKTLNTPVSAVLQSQPMALVHAVAPVSMEMNVAGSSTMASDAKSVNKTKAYRLLREHLWDPKFKSKHLAEIQANNGKPRWNTAVNFNQSPNTELTENLVAYLERNFVGAGLRKSDVRDFVYTNFTSRKRAANKSQAKKKSDNARNRRSSREKEHLKRRKTAYQSNKTAIDDEMKRDCSGLIIEEAMSVGESDDGTSPHVSYSGLRLRRPGWRSDEYNHFITLVDNKVVADLGLNSHQLLSRAFGETVEGPVPDAIASQFPQWALRNGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NDT5</accession>
    <name>A0A162NDT5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_145784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291428.1">
        <property type="nucleotide sequence ID" value="XM_018431535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NDT5"/>
    <dbReference type="STRING" id="763407.A0A162NDT5"/>
    <dbReference type="GeneID" id="28992441"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145784"/>
    <dbReference type="InParanoid" id="A0A162NDT5"/>
    <dbReference type="OrthoDB" id="5580261at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018811">
        <property type="entry name" value="MRX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002:SF1">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10306">
        <property type="entry name" value="FLILHELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="161" mass="18190" checksum="653661AEA330CE5B" modified="2016-07-06" version="1">MRFLYPITHNVRRFTTANTLKVEQKATRGWRKYVQQFRDKPASYVTTFAILHEVTAIIPFPFIYYALDASALSIPVSETAITEGNRFISKVRVHYGYEPLDPQSRVMINLATTYAAVKLLMPVRLAASAALTPFFAEKWVGPLVGLISRLGGKIRSPKPKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NJH1</accession>
    <name>A0A162NJH1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_144139</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292818.1">
        <property type="nucleotide sequence ID" value="XM_018431148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NJH1"/>
    <dbReference type="STRING" id="763407.A0A162NJH1"/>
    <dbReference type="GeneID" id="28992054"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144139"/>
    <dbReference type="InParanoid" id="A0A162NJH1"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF159">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="171"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD74778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="212" mass="24204" checksum="89286A1FED8C5F14" modified="2016-07-06" version="1">MDIIELIHSEKSSAKLRYPCDWPGCEKSFARPSDIVRHHRTHTNDRPFACNVQSCEKRFIQRSALTVHLRTHSGERPHACEFDGCEKRFSDSSALAREYTLVTARTSVKQNIAKKGYYTKKRFLARHIRTTHGPKGYFQALPENYNKGQLIKRKPSIIPEEQPQYQYLLSPPSSQCSTTISPQNSPTFSLSPLSQPSHGPPSSESLSQYLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NK64</accession>
    <name>A0A162NK64_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_171187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288474.1">
        <property type="nucleotide sequence ID" value="XM_018436536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NK64"/>
    <dbReference type="GeneID" id="28997442"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171187"/>
    <dbReference type="InParanoid" id="A0A162NK64"/>
    <dbReference type="OrthoDB" id="2266849at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="331" mass="35965" checksum="694BD87D967AD026" modified="2016-07-06" version="1">MARIPLTSVLPLLVFLLADVPRKLLNPDSIFTFPILFVLDAILSTIYKIHGPQSIEPTNRKLIAGPDAADIAVSALGDTECLKDTPLEIFLGLEDNNNDNNNNDNNNSTPSTHPFTNTIANNSNSSSPTLSPLSFTSSSPFSTTISKNFITDEPESMDCRAPWDDTPVANTVEGCQDNLCPLPDFSSFSPTPTHSRSTPVSLGNRRRQRQLPPLEPLELDFFGPLSPPSLSPSMSVCSSISSASIDSVIPILARRRPSRVEHVVRLIEKGELKASASTPTTSTTSGVRPRGQSVSSLDSSTRPKPIRNRTFGFKPIKGVWEKRIQDTASIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NKI0</accession>
    <name>A0A162NKI0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_111381</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Binds to F-actin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the WD repeat coronin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293098.1">
        <property type="nucleotide sequence ID" value="XM_018428212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NKI0"/>
    <dbReference type="FunCoup" id="A0A162NKI0">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NKI0"/>
    <dbReference type="GeneID" id="28989118"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_111381"/>
    <dbReference type="InParanoid" id="A0A162NKI0"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000197">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="10">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="127"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="170"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD75058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="434" mass="48230" checksum="6299944FA9900312" modified="2016-07-06" version="1">MSRFVRASKYRHVYGSAAKRDGCYDNIRVSANAWDTNMVKLNPLFLSVNWNASGGGAFAVIPLSTVGKLPDNYPLYRGHTGPVLDTDFNPFNDYVIASGAEDGKVMIWAIPEVYEEDLEEVAPVSKLSGHGRKVGQVLFHPVADNVLASASTDLTIKLWDIEKGIERQQITGHTEIIQSLAWNYNGSLLATTCRDKKLRVFDVRSNKIVQEGPGHQGVKGSRVVWLGETDRLATTGFSRMSDRQLNLWDTTDLSKPIKTEFLDTSSGVLMPFYDADTKMLYLAGKGDGNIRYYEYENDELFPLSEFKSGDPQRGMGFLPKRGVNVADCEIARAYKVGTTLIEPISFTVPRKSDAFQSDIFPPTIGDEPALTADEWFGGKNANPKLIDLEAGFSVKEKKEFVPSAPVEEQQAKSPTTTMHEKDVIYIFQKKVGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PLA1</accession>
    <name>A0A162PLA1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_168330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291947.1">
        <property type="nucleotide sequence ID" value="XM_018435839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PLA1"/>
    <dbReference type="STRING" id="763407.A0A162PLA1"/>
    <dbReference type="GeneID" id="28996745"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168330"/>
    <dbReference type="InParanoid" id="A0A162PLA1"/>
    <dbReference type="OrthoDB" id="78308at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="575" mass="66210" checksum="5A3D55208738A76E" modified="2016-07-06" version="1">MLGRIIHWNEMYLKPLKSTDSCDETFSRLILSSNVNMGVILSKIHDPEFKAERFFVAATELAQKLNDPEAERECWHEFGKFFQRNGRWDSAMMCQKKEIKITKMLNLKEEEVACRIDNIKLYLEIEKFDECKKHFKRIKDLTTELEDESLHSEITSLVWDIESIHKEIKEVPLEEPLGRAKLYLELGNNNILHQLGEIFLEVGMKRAAAKSAAEGLLNIIPGFKHTDEMSSMVQIGLMHIEAESSENTTLKPYDVQLAFNQTILFIIHREIKTRKLYLENCIKVYKRMIRLCRYYDKEATSEKWAVIAKAAKEQYHDLEESLAEDIEKTGIVNTSGPQTDDIDPLQKNLRVRINIKGTQVVIGLSCLKEYTTVKWISRQLINKTWRIYGERISIDYLIINGSKVQSPEAKIQISKGHKQEIRVHVKAHQKGLDEYYENVCSRLKIPIVPRLKDALKDHTDNELNLSGLALSSEDVPVLRFLLARKGPLDNLDLSANLLDDDAIIKLLTDMRCPRHVDLRSNLLTGKCLKHIFKIGQGRLSSLRVSYNKIESTSKHVISDLSALCTSLEVLDLEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PRU0</accession>
    <name>A0A162PRU0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_169454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290356.1">
        <property type="nucleotide sequence ID" value="XM_018436075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PRU0"/>
    <dbReference type="STRING" id="763407.A0A162PRU0"/>
    <dbReference type="GeneID" id="28996981"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169454"/>
    <dbReference type="InParanoid" id="A0A162PRU0"/>
    <dbReference type="OrthoDB" id="2379842at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22744">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="47835" checksum="E160588529D59B1E" modified="2016-07-06" version="1">MQEIVKLEALFRSCEGSQQVANLLQKIKKVTSEFEGKTGHPSINFQAPEKNKYPGRRKGGARPKYLPKDFGRANWRKISVSSGHAGLKAMVRLRARTRDGKPAATQKTKNNKKQNKSKKEPLDLIDATKNKIKQIKKEPLDPVDATKNKTKKIKQEPLDPVDATKEIGFKRPATAQEDYQYDYRTSVGKRVKFQPGFPVSHEIVDDVKGGFNPTADGWCGFRVLAHLIYKDQEKFPLVKRDMLATLPKYNSIYASTFGTDVKQLEDIIKHGSDICITNSNSNFIPACLDASMWFSASDCAQLAADTYKRPVCVYSDNPNTPSVSFLPFTLPKNISKHQQPLIFNHVNNNHWTTVHLSRNVSRKWPTIPELFFLGCVRNQIPDNFDTYWNKFKEFNKYDRRNAMFSFLSDQEEHVDLTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PT33</accession>
    <name>A0A162PT33_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CCHC-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_166953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293767.1">
        <property type="nucleotide sequence ID" value="XM_018435542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PT33"/>
    <dbReference type="GeneID" id="28996448"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166953"/>
    <dbReference type="InParanoid" id="A0A162PT33"/>
    <dbReference type="OrthoDB" id="2250058at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD75727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="247" mass="28415" checksum="90C0DC1D041A84B3" modified="2016-07-06" version="1">MNPGERHQENFDKKTLSQFEIEERVQDLLPKELVNDYKKNRCVPHIPEEQRLKNTPAREQKWSELAKKLAATLTGKNKELEEMAPQTATVTAEAIAAAVAEAMKAITAQQESRAERIKQPDCFRGERSAAVVDGWLHAVECYTNGLQLGYQNNYASVPPPQQYQQQYQPQYQQQQYQYSGPEPMDLDAINNRHSNYQSRPPPRRTNATCHWCGDSGHFKRNCRDRLAAIKKLDEERLKKQGFCEAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PYH9</accession>
    <name>A0A162PYH9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_64354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293476.1">
        <property type="nucleotide sequence ID" value="XM_018441285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PYH9"/>
    <dbReference type="GeneID" id="29002191"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64354"/>
    <dbReference type="InParanoid" id="A0A162PYH9"/>
    <dbReference type="OrthoDB" id="2351036at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13384">
        <property type="entry name" value="HTH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="123" mass="13969" checksum="98ECEDD410F4299A" modified="2016-07-06" version="1">MSQQIDKKSLKRRQLTDYERGLIIGSATQHVTFAEISEKTGIPLPTVYATVRRWKKTGTALTEKRKGTTKILNERDLRHLKNEMKSNPSATLGNLTTSMAETIGRSISKSTIRRAIRRLENDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PYZ3</accession>
    <name>A0A162PYZ3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_180839</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293636.1">
        <property type="nucleotide sequence ID" value="XM_018438366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PYZ3"/>
    <dbReference type="FunCoup" id="A0A162PYZ3">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162PYZ3"/>
    <dbReference type="GeneID" id="28999272"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_180839"/>
    <dbReference type="InParanoid" id="A0A162PYZ3"/>
    <dbReference type="OrthoDB" id="10261039at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD75596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="574" mass="63771" checksum="6A16A33FC2B94254" modified="2016-07-06" version="1">MLRGASVLTRSTARISGRSTRLGSSVRCYSTVDEPKRGSIGKTLLWTTLLTTAAYSGATYYALQNKAFYDTFTTYVPGGEQVLDFLEDLSQDEELRQYATKANELKDFAVIHSALLKTKALEAKDKATEFYENTHDLVSKLKGEDQDVRAQGPAPITRVKRTLKKDGLFTNVMEGGEPVKAAFTPTNIPDLDGLAQTMARLVAVLNESGMTGHAKRLVDFASRDIQLLASDLKSQESEQAELVKQTAALLQIADELQNKVTEHRKEIASKVEEAKAQSDARIAEKETTMRDAFAVENATLEQHLMEVGQKELEHQRTVYLEALTNELKERAIELQRGYVAQVKKQVEEERGGRLSKVDEVVSRQGALERMACTNAEYLDDSRKAHQLLVAIESLKQVAYAGNKQTFLDELKALEALSASSSPFANNAEKQNEALVHVVVSSISKTVAENGIDSLAQLVDRFEIVSREVREASLIPEEGSSMMSHVLSIILSKFLFPKEGLVEGDDIEARLARAKYHLDYSHDLESAAREVNQLKGWPKTLATDWLNAARRHLEVKQALEVMRTQAVLTSMLQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q121</accession>
    <name>A0A162Q121_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_143210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294266.1">
        <property type="nucleotide sequence ID" value="XM_018430950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q121"/>
    <dbReference type="FunCoup" id="A0A162Q121">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162Q121"/>
    <dbReference type="GeneID" id="28991856"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143210"/>
    <dbReference type="InParanoid" id="A0A162Q121"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="101"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="319" mass="35989" checksum="A29BF2FF534C8280" modified="2016-07-06" version="1">MAIHKTAQESDAIIKELRLKLGPKSKTMKDEYLIQFLVARSWSVSGAKNQIEKTLEWREKHKVNEHPVATGENKLPLLYPIRGYNSIPDGNLEAAPGLSESVLRINKYMGGSCLHKTDKNGCPIYIERLGYHAAKEIAKYTTVEEVSNYHIGCNEFLNRVIMEDCSRVANKTINHETVIFDCTGMGWHQLHMPALHYLRAISDADQNYYPETLSRLFLVNAPSSFVFVWKIVKAWLDPGTIDKIKILGSDYKEELLQYIPAENLPSFLGGECTCAHMPGGCVPSQMLKNIPSLVPQSHNEKVSTPYNTDIMQKGTSYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q5A8</accession>
    <name>A0A162Q5A8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_140217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298256.1">
        <property type="nucleotide sequence ID" value="XM_018430355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q5A8"/>
    <dbReference type="GeneID" id="28991261"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_140217"/>
    <dbReference type="InParanoid" id="A0A162Q5A8"/>
    <dbReference type="OrthoDB" id="5588333at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="534" mass="59520" checksum="DFDE72DBC9FAF44C" modified="2016-07-06" version="1">MTTKLSGTKLCNLCQSVCQCVSLSPSGPQPHHEDSGCNNCFLSGPPIHKAFDWNDLSLLSQQHQHVLFVNASNTRWDCTLGIHTAHGYWTHEEAKISYPHQQHYINGVPQQARQLTCLPSDTTGHKDLKIVSLPWSLIGCTAYCREGQCHCQSEILPDFYKEPLENLQGNVQYSTVNMETIQYMAGELDGDLGGSDLAECHMVSPSPEDVSGFSPNSEQSVYSFRLSQDPMVIEELDVEAHHIQTIKRKFDNTDLTDESVLLLIDSALTNTPTNHIYQWGQHLFIAWALQQAVSLTEFILQDLINFLVYQHNEGFGMSTIKNHYTAALKLHTNPESLRFHEDVWTVFSCLALQASPLRQSRPSIDLAPTLNHVASIVSITSTSLAPLLRKTVFLIVMAAFIHPSNLACLQLLDHPQASTAHPPECLFVNAHQSTNSVQVSIISSWLCSLLQLSMHEPVLVQSIASTLALKRDMSLDNIVTLGNWSSHKVFQQHYNRNHILSADFTNVVLRPLASILVLGLVVLTVVHSDLENIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T114</accession>
    <name>A0A162T114_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_160832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441028">
        <property type="protein sequence ID" value="OAD65382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283422.1">
        <property type="nucleotide sequence ID" value="XM_018434267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T114"/>
    <dbReference type="GeneID" id="28995173"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160832"/>
    <dbReference type="InParanoid" id="A0A162T114"/>
    <dbReference type="OrthoDB" id="5591786at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014839">
        <property type="entry name" value="Crt10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08728">
        <property type="entry name" value="CRT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="246" mass="27976" checksum="CD95472EF9A6E2F1" modified="2016-07-06" version="1">MGLPNLQRQRRRGFLDVPEGSWDDVISPSAQQQPNQEEESESESEDEASSDEVVSSGRRIPRVVHLKTDPKIPNAGAEISEQKKGEKKKKREVGEYLVFTTAKDVYLLNTTRPRITTIRVEHEAISKIDVRSDRMLLTMDRINMVEWIPELELLVAASQKGTVALTRVLQVELDDGRQTCLFNNECYLPLGGLQPTPLYGMTVQRIARDNLSPPIFYIYLFYYDGAVLGYKLSRNKTEVDVNSFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T2Z5</accession>
    <name>A0A162T2Z5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_175823</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441027">
        <property type="protein sequence ID" value="OAD65862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283902.1">
        <property type="nucleotide sequence ID" value="XM_018437584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T2Z5"/>
    <dbReference type="STRING" id="763407.A0A162T2Z5"/>
    <dbReference type="GeneID" id="28998490"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175823"/>
    <dbReference type="InParanoid" id="A0A162T2Z5"/>
    <dbReference type="OrthoDB" id="2019556at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080122">
        <property type="term" value="F:AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044610">
        <property type="term" value="F:FMN transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="102"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="196"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD65862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="32441" checksum="D20FA5E9323182E7" modified="2016-07-06" version="1">MSDNVAHALSGAGGGIVSMALTYPLVSISSRLQVQKNDDSKDAYKNTADAFFKILAKEGPKGLYAGLSSGVFGIAITNGIYYYCYEAVKAVFEKAKAQGKPMSTGESMLAGALAGCAVVLATNPIWTINTRLTVRKGIDGEAKLNMFTVGRSIVEKEGVAGLYAGVKAALILVINPIIQYTVFEQLKNKVSKSRALSNFDFFLLGAISKLCATGITYPYLVIKSRMQSAQGDDEKYPSIWEGFKKIIATEGVKGLYKGISSKIVQSVLTAAFLFMAKEILFDWAVWILVVAGARKARVAAGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T3A5</accession>
    <name>A0A162T3A5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_175680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441007">
        <property type="protein sequence ID" value="OAD65942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283982.1">
        <property type="nucleotide sequence ID" value="XM_018437548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T3A5"/>
    <dbReference type="GeneID" id="28998454"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175680"/>
    <dbReference type="InParanoid" id="A0A162T3A5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="194" mass="20836" checksum="CFFC03F97EEEFE70" modified="2016-07-06" version="1">MAVHNTLSSNEICGYASAGTGFKKENITVVIGFNFDSAAMLVLCGYASAGTGFKKENITVVIGFNFDSAAKLVLVQVSKKKTLLCAAKLVLVQVSKKENDTVVISFNLDSVANLVLVQVSKKKLLCGEASVGTGFKKENITVGITVDFEGDLFATLNMAENPVHRFIATFVVMFASCYVVNKGTVFLIEFINKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T580</accession>
    <name>A0A162T580_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_175164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441003">
        <property type="protein sequence ID" value="OAD66352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284392.1">
        <property type="nucleotide sequence ID" value="XM_018437433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T580"/>
    <dbReference type="GeneID" id="28998339"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175164"/>
    <dbReference type="InParanoid" id="A0A162T580"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="423" mass="47370" checksum="49BFE24306E62DBB" modified="2016-07-06" version="1">MIYLMIMASRTNINQNAHTNGSTSRPLINAVNTGCIESSNPMIAPRPENMSIPVSEFNDVVSLLTTLNDKMTDVSSDVSELKVQCQVGAQSTGMQAVLDSDMDPQDIISSSRHSKISNIIRGRLKDINLKTDDLELIGENDDKPTWDVNVGLSDEFNKNLASDLMLYIRRQPVAAIVSPKELCGIICLLSCHNYSTCGISECIYCLTSVGVTIMTSSHKSALGLPTKLAPYRSDTVYPAMIATTLSQYEYVLICDKSNIRVSGSPQYLLNMFLDVINPTTKCLDHHNSYYNQLAASKLTEEDRQTNTTSNRRGNRKTALNKRRKRTYTKHKDAVTEKFNRDYNGVFYRDAMSGDETETNTSVVASRPDWRSDELNTVFDFLDELARDDLGKRATQLKSRSHVLVHKTIPRGLVTKMPTWSKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TQG0</accession>
    <name>A0A162TQG0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_172817</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287023.1">
        <property type="nucleotide sequence ID" value="XM_018436878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TQG0"/>
    <dbReference type="STRING" id="763407.A0A162TQG0"/>
    <dbReference type="GeneID" id="28997784"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172817"/>
    <dbReference type="InParanoid" id="A0A162TQG0"/>
    <dbReference type="OrthoDB" id="340227at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058699">
        <property type="entry name" value="RRM_LARP4/4B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF131">
        <property type="entry name" value="LA-RELATED PROTEIN LARP4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26088">
        <property type="entry name" value="RRM_LARP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="5">
        <location>
            <begin position="12"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="179"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD68983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="289" mass="32495" checksum="1E79A8A4797D41A5" modified="2016-07-06" version="1">MLCSPEEHSFPRGDEQDDIVIIMQQEDVMFGAGHEITSSDKTSHMDNNLYVPIDLIAGFKRVQMWTTDREVIVDILKSSDVVQVDEQSQKVRPALSLQRTTIILRDIPSGTEEKEILDFLDSLQSPPVKNIKADLGMWYIAYETEKNAVEMLKRVRNKIFKGHPVAVRMKSEPMLRRMQATLQSSQTVKESKQPQPQAQQQPQPQAQPQKEAEAETCVQTSQPEHQNLSIKIPQEVKSTTGLPLLSVTQPGSHTTPMPVCSYASILKRSPSASSDKCQDQDQGQTQTQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TS10</accession>
    <name>A0A162TS10_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_171328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288622.1">
        <property type="nucleotide sequence ID" value="XM_018436574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TS10"/>
    <dbReference type="STRING" id="763407.A0A162TS10"/>
    <dbReference type="GeneID" id="28997480"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171328"/>
    <dbReference type="InParanoid" id="A0A162TS10"/>
    <dbReference type="OrthoDB" id="2283240at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="31969" checksum="560DB5D262EC5199" modified="2016-07-06" version="1">MIDCSPIEISAIKEVFGNSVNILLYHWHIKRAWEVNIKKHIKVQNSTHASNIACNSVCAVLSNMMHATTSVAYDTLYNEFLMKFGEYENFILYFNRMWVATFHTNNLIESYYNQLKTFYLERVRSLRVDRLIYLLAKVLTLDYRQESVKTLYGFQSNGFLQNCTCPDTSKLCKRIFLINRMLDIPYSLRQSLSSSSSAVYISNTDTKVVVDTSLLSDEIEADIMKYFQLYSVELDTKIAEYKRIPEDMSQFLDTLKFAYNKLKEHGFLSQSRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U9R2</accession>
    <name>A0A162U9R2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_61321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292662.1">
        <property type="nucleotide sequence ID" value="XM_018440789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U9R2"/>
    <dbReference type="STRING" id="763407.A0A162U9R2"/>
    <dbReference type="GeneID" id="29001695"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61321"/>
    <dbReference type="InParanoid" id="A0A162U9R2"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="39"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="262" mass="29229" checksum="6664F8B969684EE4" modified="2016-07-06" version="1">MATKDNWSSDLYSTNASFVPKLGSIILGMLDAKPSEHILDLGCGDGILTASLGDQCASVVGVDFSSDMIEHAISSNKHNNIKYCVVDGHYLPEWFDKSNQSSFDAVFSNAALHWLKEPVKAINGMHHVLKPNGRAVLEFGGHMNVGEIHTALITALSKRGFDGKALSPWFFPSAEYYSDLLEQNGFDVATCELVPRITQLDTDIKGWINTFGFSFFKDLTDVEKGQIIDEVVEHLRPGYQREDGKWFVMYVRLRVIAHKRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UAH0</accession>
    <name>A0A162UAH0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_71811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291683.1">
        <property type="nucleotide sequence ID" value="XM_018442544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UAH0"/>
    <dbReference type="GeneID" id="29003450"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71811"/>
    <dbReference type="InParanoid" id="A0A162UAH0"/>
    <dbReference type="OrthoDB" id="2241374at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="6"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="689" mass="79985" checksum="813B5848B2FC929D" modified="2016-07-06" version="1">MLMLASELPFEILTLIATHLSQKDKLCCMSVCRAWNVPFRDALWDTVDINRKERLEAICNLSTVQQNIYQTQGNRVQALRLKRRIETTDHQLCILQRFFQQIKRLNIELNALTVKDFGRMSDWSLWRSLTDLKMYIPRLDDGRRKKDLVDILSCLPRLVRLDISEHSRFSAHRYTWDTLESIHAHLPRLKYLQLSLPFDPIPANDIKHIKSITPATNISTVRLLGHNVNLGWLYYFAVKYPNVHTLESRLLQREASWTRDIPDNETLRLLSSFQRPFPHLKAVTITQEATPGLQLDLFLEILQRFFGHLKSINYNLHTTGGSSLDNDHPQSISDNPILLSSSALEKLVLQVGPISTTPQLRSPLRLGVNSRLVELDLNFFDTSIHLDSVLNDCVSLKRMKLRSGVITLTDHLADRPSSSSSSSSSALLFAHGLESVELCRAKVDPKVFNYLSFRCRFLNEMILNDVSIPALISKETGSFCLDMSYTHFKNLKLHGVEFYAVDGSNWNEEHPDIDQNIYILTIDRTHSSPIYPHQLDIDRHEPSDNYSSNYDNNNQYQNHLPVQKRLWFHHCWGNTKDDLKKEVWVLGYAEAQFAEKYFELFSPEKKYIRRTAEEAAFHSQLVEKRFWKDDLLRGHITLRCGYVGKYSIDSTPFDHDGYITKSGVYLFLSLCLYILSIFRDIIYYQYIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UHE7</accession>
    <name>A0A162UHE7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_123789</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293283.1">
        <property type="nucleotide sequence ID" value="XM_018428952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UHE7"/>
    <dbReference type="STRING" id="763407.A0A162UHE7"/>
    <dbReference type="GeneID" id="28989858"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_123789"/>
    <dbReference type="InParanoid" id="A0A162UHE7"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01871">
        <property type="entry name" value="Rac1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000088">
        <property type="entry name" value="Ras-related C3 botulinum toxin substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD75243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="192" mass="21335" checksum="F49AFBB4750D90A5" modified="2016-07-06" version="1">MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPINLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPPSFENVKTKWYPEISHHAPNTPMILVGTKLDLREDPETIAKLRQKHMAPITYSQSLQMAKDIGAVKYLECSALTQKGLKNVFDEAIRAVLCPAPPPKRQKKCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UM41</accession>
    <name>A0A162UM41_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription initiation factor TFIID subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_16454</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294303.1">
        <property type="nucleotide sequence ID" value="XM_018435029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UM41"/>
    <dbReference type="FunCoup" id="A0A162UM41">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UM41"/>
    <dbReference type="GeneID" id="28995935"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_16454"/>
    <dbReference type="InParanoid" id="A0A162UM41"/>
    <dbReference type="OrthoDB" id="341924at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000018">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD76263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="16269" checksum="8BB23D591C559B0C" modified="2016-07-06" version="1">MAIESHTFQKQQQQTRPRDARIIALILQSLGVEDYDPKVVQQLLEFAHRYTTDVFQDALVYAEHAAKSDLDLDDIQLAIQGRVNHSFTTPPPKEFLLELAQEKNKAPLPLIPEKYGIRLPAEKHCLSGLNFSIIPDVCYLLIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UMK5</accession>
    <name>A0A162UMK5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_142565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295092.1">
        <property type="nucleotide sequence ID" value="XM_018430835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UMK5"/>
    <dbReference type="STRING" id="763407.A0A162UMK5"/>
    <dbReference type="GeneID" id="28991741"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_142565"/>
    <dbReference type="InParanoid" id="A0A162UMK5"/>
    <dbReference type="OrthoDB" id="2404451at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD77052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="818" mass="93150" checksum="7D7384C550121546" modified="2016-07-06" version="1">MSSSNASQQRDRIFTQQYQCNQCVLFFDNYQKLQNHKRIHRGDSATMTEIDQSILDDVDMYHDENDTSNEDESVSNSEYTMESMKLNNTISYKCACNFEDSESKAHIYDNSQISTNTFTKAEFMKPGAKISHGETVDVLLKSNSSVKGHKYDSDTSRQYETYVSRNILSQMLADPATRELLCYRANWESVAGQLTDIFDSNNYKQLVQQSLFSNPNDIAIGLYTNRFVNQKKGKNSYTIIHCIIFNLDPSIRYTNKYLLQLAILSGPKKPTHLDSFLILIINELRDLEAHGLVVKHNGVELCRSKVYLLLASGNIPAVADMAHIGSHTSLFGCRFWETKGKCPTNRRHGMYFDDISARLRPLEDFKVGNPSKNIYQPSIYTQLSTFSGSLFFALDELHLIARGIGKLVYDLITVTLTKETKFYYTHPDNTLNTTKYPFHILRADLVTIGNCITSSRKYIPTSFQGSFDNIFVKIDSTCAVDWLNFLLYLVPTLVVPYLPNRAVKTALLSLVKGCALALQWTLTSELLDEMESKQQGPLQCYFTRSMERVIGVFSKLIKFKSKGGQNASFLIKRFAIHNYTSMAISICDEVNLTRPKLYGRESYMDLPNDSSGVQLWEPFHQFANLNDDSVEGVGGPSVKEALLKYYQRTTGLTSHEFGDSVVVVAARLWMNSTIYSSCMYQRKKNKTSRSNHYVMFTCPYRNNHNVIVHSWLVGTVQFYFQHVDFHGFPHFLAFVEVMKEHDVAGHDSSVPIIKQQSQSTCTLGHQTQPTYAVISVNDICHQVGLVQYPPNGNQFYIIAPYYIFNNNMHITKGNLSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UNJ9</accession>
    <name>A0A162UNJ9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_142117</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294643.1">
        <property type="nucleotide sequence ID" value="XM_018430742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UNJ9"/>
    <dbReference type="STRING" id="763407.A0A162UNJ9"/>
    <dbReference type="GeneID" id="28991648"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_142117"/>
    <dbReference type="InParanoid" id="A0A162UNJ9"/>
    <dbReference type="OrthoDB" id="2256373at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF489">
        <property type="entry name" value="RING FINGER DOMAIN AND KELCH REPEAT-CONTAINING PROTEIN DDB_G0271372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="167"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD76603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="447" mass="52059" checksum="24ADCFE9B99CFA82" modified="2016-07-06" version="1">MTLHDYGDTSYYTYYWRVPRFSSIPLKTEVRSAWFRLDKYSMMIQFYKGTEDEPNALQVDLVIPRVHERLSDEEMIEPLNAFNPSIVEISDETKYECKRFISLDQLSTIITMDEIRFSVCPENKSSSGYNMSPLKSLSPINIKSFRESEIFHDVLIRVINDNSVQDVSVELYVNHDDQTASETSSITGTPLEQPEEESFFVHRLVLSAASDLIFEKLMEEKHEGFKREIVIRGVDPRIFERILDFVYGLSPGPNSVQEAIDLIPVTYQLKLDGIRQYLFQYLQLNISNQNMWGVWNCAEKFMCPDTQDICERKMKTKPLDTLQSVYWFSSDPKVVLNALKVDYLQKPVDEVVFYEAALIWRDAQIKKAKKWLYLDNKKVALSDVFAQIIACIRFPQMDASFLSEVVEKNEAVMNTTGVQELIFEAYRFQACGKKKITSVRCYPRKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162USR0</accession>
    <name>A0A162USR0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic peptide chain release factor GTP-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ERF-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">ERF2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Polypeptide release factor 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Translation release factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHYBLDRAFT_108178</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295842.1">
        <property type="nucleotide sequence ID" value="XM_018428032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162USR0"/>
    <dbReference type="FunCoup" id="A0A162USR0">
        <property type="interactions" value="477"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162USR0"/>
    <dbReference type="GeneID" id="28988938"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_108178"/>
    <dbReference type="InParanoid" id="A0A162USR0"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000017">
        <property type="entry name" value="Eukaryotic peptide chain release factor GTP-binding subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000503">
        <property type="entry name" value="Peptide chain release factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003285">
        <property type="entry name" value="Sup35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01343">
        <property type="entry name" value="YEASTERF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tr-type G" evidence="14">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAD77802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="434" mass="48573" checksum="2BAFB27200D2360A" modified="2016-07-06" version="1" fragment="single">KEHLNVVFMGHVDAGKSTMGGNILFLTGMVDKRTMEKYEKEAKEAGRESWYLSWALDTNVEERAKGKTVECGRAYFETDKRRYTILDAPGHKNFVPSMISGASQADVGVLVISARKGEFETGFERGGQTREHTMLAKTSGVNKMIIAINKMDDPTVQWDKARYDEILSKLTPFLKQTGFNPKTDIAFMPVSGFTGANIKDRSSECTWYSGPSLLEYLDDMKTLDRKLNAPLMVPIAEKYKDMGTIIVGKIESGSVRKGQNVLLMPNKRVTEVTAIYNETEDEVDHAICGDNIRMRLKGVEEDEVSPGFMLCDKKKPVKTTTVFEAQLAILDHKNIICAGYTAVLHLHASVEEITLTSLLHLIDKKTGRKSKRPPQFVKMGQKVIARVETAAPMCIETFEDYPQLGRFTLRDEGKTIAIGRVVKVLESETAEQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V0E9</accession>
    <name>A0A162V0E9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_139217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297222.1">
        <property type="nucleotide sequence ID" value="XM_018430180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V0E9"/>
    <dbReference type="GeneID" id="28991086"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139217"/>
    <dbReference type="InParanoid" id="A0A162V0E9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD79182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="103" mass="11626" checksum="BB75DE7543826AA5" modified="2016-07-06" version="1">MTVCTDLEPLFLREAHLSAMQLQYKQIKCRLNDTSLGPQQPLNQTRSLKEIFGLDVSHFGRWTSPVDNTSSSESSQSNLQAQILGYHMCPTNDFGPTTSLLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V1K8</accession>
    <name>A0A162V1K8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_162455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297422.1">
        <property type="nucleotide sequence ID" value="XM_018434630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V1K8"/>
    <dbReference type="GeneID" id="28995536"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162455"/>
    <dbReference type="InParanoid" id="A0A162V1K8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="111" mass="12760" checksum="72ACA9F62CE4044B" modified="2016-07-06" version="1">MRHKVVFQDDGGHLLLEYYFLQPAFCQAQYQICVSLFGYTLSDISRMYLYSKTTGIVLIILKNMFISILCQVFSAFIPAIKRARSISDYNSNSIKTVAKLGFLSRKDFPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V6I2</accession>
    <name>A0A162V6I2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zf-CHY-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_99199</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298382.1">
        <property type="nucleotide sequence ID" value="XM_018444087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V6I2"/>
    <dbReference type="FunCoup" id="A0A162V6I2">
        <property type="interactions" value="494"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162V6I2"/>
    <dbReference type="GeneID" id="29004992"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_99199"/>
    <dbReference type="InParanoid" id="A0A162V6I2"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16464">
        <property type="entry name" value="RING-H2_Pirh2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039512">
        <property type="entry name" value="RCHY1_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017921">
        <property type="entry name" value="Znf_CTCHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037275">
        <property type="entry name" value="Znf_CTCHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319:SF0">
        <property type="entry name" value="AND RING FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319">
        <property type="entry name" value="RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14599">
        <property type="entry name" value="zinc_ribbon_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161245">
        <property type="entry name" value="Zinc hairpin stack"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51270">
        <property type="entry name" value="ZF_CTCHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="7">
        <location>
            <begin position="109"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="CTCHY-type" evidence="8">
        <location>
            <begin position="178"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="245"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD80342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="40811" checksum="6E528DCC08B76AC8" modified="2016-07-06" version="1" fragment="single">DNILNDEESDRLNSEDQTRQQPNRNNESSEAHQSTGTNRQRNSLDQAELRKKIIQIQHDTSVDPKQKARMMQHLMSHGVLPATPTADTHKNKQPQVQTEDIYAVSYHKKEDGILGCQHYQRNCKLQAACCEKIFVCRFCHDEASDHAIVRVETKNMLCMLCKTIQPAGKDCHKCGEQMAAYYCDKCKLWDNIPNKEIYHCDDCGICRRGKGLGEDFFHCMKCNICMVISIKDKHRCIERNLESDCPICGEYMFTSTAKVIFMPCGHCIHKHCYETYLQRAYQCPTCLKSLCNMEDYFNRLDQELQRQPMPAEYENYLSYIFCNDCEEKSVAKYHFFYHKCKNCKSYNTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WBB0</accession>
    <name>A0A162WBB0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_69878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WBB0"/>
    <dbReference type="GeneID" id="29003084"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_69878"/>
    <dbReference type="InParanoid" id="A0A162WBB0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="197" mass="22431" checksum="375928836FE994EC" modified="2016-07-06" version="1">MNWRKNIWSTNRTINRYIVAIKIRSNDFFVPLDTNIVTENLSLNDFNISEILSHLNTLLELYDPSVSRKCFTFYQSKLNRSIQPKDKVPLIAFSVGMFEKGTVKFKGVPVCYPVENVEQCGSGTSTHVLNMVTVPLCILSEKGRPKGFKPQKKEISVANRASLTRFRLSQVFAIDYFNYLDSKCTTIFVGQANLKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WPI4</accession>
    <name>A0A162WPI4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_182726</name>
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    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WPI4"/>
    <dbReference type="GeneID" id="28999569"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_182726"/>
    <dbReference type="InParanoid" id="A0A162WPI4"/>
    <dbReference type="OrthoDB" id="5580129at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="128" mass="13906" checksum="A06F7F5945F27930" modified="2016-07-06" version="1">MSDDSLSALSQKYQQLKTEGSDSNDNKYKVMKAMADQLGLPGTPAADILSHFGKPDELTPSLQQQGQAHIATMPGPAFDAATASALGGNQSNSSYYLVYYLKSKNEYLYFKVDSAKETVITSDWNLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WPR1</accession>
    <name>A0A162WPR1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_149241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287495.1">
        <property type="nucleotide sequence ID" value="XM_018432241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WPR1"/>
    <dbReference type="GeneID" id="28993147"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149241"/>
    <dbReference type="InParanoid" id="A0A162WPR1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="61" mass="6687" checksum="06A0BCBB46914972" modified="2016-07-06" version="1">MLCPLDIPGKNEKFQYKDTGKLSSPPMALIKDTAYFHISRLYPLTAKEVSFNSGMPPLGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WT73</accession>
    <name>A0A162WT73_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_170882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288835.1">
        <property type="nucleotide sequence ID" value="XM_018436443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WT73"/>
    <dbReference type="GeneID" id="28997349"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170882"/>
    <dbReference type="InParanoid" id="A0A162WT73"/>
    <dbReference type="OrthoDB" id="2245921at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="117" mass="12815" checksum="D60414A40414C34D" modified="2016-07-06" version="1">MPTNTNLPAQLKRKNLEEEIAPSPKRVHPSETTVTMEECGDNVMDLCDNQTFSISPSDLPPRSTTPPLGMTLAHYDASVGGYTASVVKTENRFDAPICSGMTPVYRAPMERWGSCLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WWR1</accession>
    <name>A0A162WWR1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_126049</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289315.1">
        <property type="nucleotide sequence ID" value="XM_018429073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WWR1"/>
    <dbReference type="STRING" id="763407.A0A162WWR1"/>
    <dbReference type="GeneID" id="28989979"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_126049"/>
    <dbReference type="InParanoid" id="A0A162WWR1"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="KA1" evidence="9">
        <location>
            <begin position="97"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD71275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="148" mass="16423" checksum="FD0064CE8D885142" modified="2016-07-06" version="1" fragment="single">MHIGKALGSYAVDFNDSKLRTHHGAVDQDALTSRPPHEVFVQVKQALGSMGIDVKRDGEYKLKCTRRKRKAAPDIIVTGSQVSGVSETTETVYGDPVVDSGEEVRFSVELCKIKNLPGLYIVDIRRMKGSVWAYKCIYHALLETLDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XAF6</accession>
    <name>A0A162XAF6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_181574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291575.1">
        <property type="nucleotide sequence ID" value="XM_018438495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XAF6"/>
    <dbReference type="GeneID" id="28999401"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_181574"/>
    <dbReference type="InParanoid" id="A0A162XAF6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="150" mass="17185" checksum="890FA11C5442F1B5" modified="2016-07-06" version="1">MFLFPSDASSSQWPSGLAKDISPKIFSTAKHDHQHDEQPSLKHAMNQKLLSHAAVIDMVHITFIKVQTTEDSLHSYKEVSLFICNVRIRMPFTMKQKARAQSVSRGDNVPFCYYMLNLKERHNGDKGITITYIRCDRNVIKTGPVRHNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XYI0</accession>
    <name>A0A162XYI0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_164230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295355.1">
        <property type="nucleotide sequence ID" value="XM_018434970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XYI0"/>
    <dbReference type="STRING" id="763407.A0A162XYI0"/>
    <dbReference type="GeneID" id="28995876"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164230"/>
    <dbReference type="InParanoid" id="A0A162XYI0"/>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF3">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="6"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD77315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="451" mass="51463" checksum="8965B195CE972A42" modified="2016-07-06" version="1">MYSEKSLLLSRLNQDIYSIIFKYLDNFSLVVLGQTCRHFYALVSRELSFTSAIWREIDCNPVPNGPPMFHNRCLVGIDNKLYLPWMTKEPVCFVFDVSLCCWENPISLEIRSTLYRPFVTPVAAIGSKVYMFGGREVSSSALSNSLWVLDINTRIVTHLDVNGIPPRPRFDHSLDVLEDRYLIVFGGMCADSPGESDVFVFDTLTNTWQEPPVDGRLPSARFGHASVMVGCYLYVYGGCLIQTQGNTVHDLLYRLDCSTWTWYKYDHPEAYLYRHRLNVPNIAEISQSLQEGFVVETTGTPPRDRFQCTMCAVGRSLLVMGGQTIRQDVNDTNELHVHSLRTIDVFDSRRKHWSSITTSTNVYPDSLTCIQIQNCLKGGHFMIVLGQHKIFEYQSKDKSRQIPDEEGYLDTTIYSHTFIQDDSQAAYDGTSSLKHNTEHICLVLSLNEYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y0S7</accession>
    <name>A0A162Y0S7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_60784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295695.1">
        <property type="nucleotide sequence ID" value="XM_018440694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y0S7"/>
    <dbReference type="GeneID" id="29001600"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_60784"/>
    <dbReference type="InParanoid" id="A0A162Y0S7"/>
    <dbReference type="OrthoDB" id="5541797at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="31300" checksum="5A082F4EBBCE7C44" modified="2016-07-06" version="1">MFNRTLAVAARQTAQTVRIAPRCLYSVQATGETRLPDTRRHDNRRKDFAGNLIKKFTGKSFLVRRANEPNESMVPTTLVRIDYLPSTATAEDIRKLVREATQKNGENIKEVVFCRTPTFHFKGRCLVHLNNTEDAASLVKYAHRRLLAGKVLNAGFGGEGNEDNVSSLLAESRTRELGSVADGTNYSGRAVEIVGFPLRSTVDHVSGKLRFKNVFPIEGVDQNLVELKTAERSSVSKFLVKFATEAEAWRCVRTFHNTRHVLRASHTYEFELRVSVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y4X6</accession>
    <name>A0A162Y4X6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_140403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296345.1">
        <property type="nucleotide sequence ID" value="XM_018430393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y4X6"/>
    <dbReference type="GeneID" id="28991299"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_140403"/>
    <dbReference type="InParanoid" id="A0A162Y4X6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="158" mass="17811" checksum="CEA1F27F3797CBDB" modified="2016-07-06" version="1">MRQSKDQSGPQDRLMARRPTRKAKACARRKGQTAPQERPQYVPAKRANQPTRKTTVCASKKGQPAHKKDHSMCQQKWLTILQERPKYAPEQTSMRPTRKANSKIWVVPPSLKAKSISKKGSNAKHILSPPLQKDQKKSELEAYTKSSTPKGSNPKTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZCT1</accession>
    <name>A0A162ZCT1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_153135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441027">
        <property type="protein sequence ID" value="OAD65881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283921.1">
        <property type="nucleotide sequence ID" value="XM_018433073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZCT1"/>
    <dbReference type="GeneID" id="28993979"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153135"/>
    <dbReference type="InParanoid" id="A0A162ZCT1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="112" mass="12565" checksum="CBCB4090EA0C846B" modified="2016-07-06" version="1">MVQDHQSRNNLTPSRNPFHTSLLLVYDAPGISPFVYELQLSQNHCPSTNRGLRNEAFGLNVLDNRVSTDDDTSSYHISLTICLTLERVTPHAQTKACNIRDTKSLRSPRSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZEU4</accession>
    <name>A0A162ZEU4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_152608</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441004">
        <property type="protein sequence ID" value="OAD66281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284321.1">
        <property type="nucleotide sequence ID" value="XM_018432961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZEU4"/>
    <dbReference type="STRING" id="763407.A0A162ZEU4"/>
    <dbReference type="GeneID" id="28993867"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152608"/>
    <dbReference type="InParanoid" id="A0A162ZEU4"/>
    <dbReference type="OrthoDB" id="2218151at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="24"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD66281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="337" mass="38243" checksum="74C5DA9D818F3F2E" modified="2016-07-06" version="1">MGRSLVLELPINVPNNMPHIGTVKTWLHILQAICTILSVSVVAPIIAIEKKYYGSSQTGPNYTLFAIIISTVTPIFLIYFPWMYDRKAKFKKLGKFCLKPRTSIVFSSFYSTIWMFAGIGMSVHATNANNCSIDTDLEETYGDTYNRDWTSQCNCAKAAAAFAWTICLLWFSSLICSGIILWNEKQWVRKNFQEHKSNKQNALQTHESKHEETLSVDDYGSKLENGSPPFQHAQLTGSNQVSPYATPVNQTPNTYQNYHHQQVDPAITPYTSPVYQQQQQQQQQSVRFNSPMPLLGNSAEAPMTHAYYQSPEYVNPQPHSSTPMTMPQPTQYNQQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZJ50</accession>
    <name>A0A162ZJ50_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="8">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_87772</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="8"/>
    <dbReference type="EMBL" id="KV441025">
        <property type="protein sequence ID" value="OAD67161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285201.1">
        <property type="nucleotide sequence ID" value="XM_018443675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZJ50"/>
    <dbReference type="STRING" id="763407.A0A162ZJ50"/>
    <dbReference type="GeneID" id="29004580"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_87772"/>
    <dbReference type="InParanoid" id="A0A162ZJ50"/>
    <dbReference type="OrthoDB" id="10262986at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="41"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="270"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD67161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="419" mass="47057" checksum="367D6DE69E6FFB28" modified="2016-07-06" version="1" fragment="single">DYAFESDPSLAKLDLVLRPEIEVRPYQTEALKAVVNQDSQDSSKHTVKSGIIVLPCGAGKSLTSILIAAAIKKPVLVVCSTIIAAEQFCNEFLRFTTLMASKTGMFAGAKKWPFNGPSGVLFTTYTMLVDNKNRASDSKRMANFVHSTDWGVIILDEVHQVPASGYSKAITKLKARVRLGLTATMLREDEKIEDLNTIVGPTLYHAKWKELADRGYIAKVICTQIETSMTDIVQKAYDAVQPSNGNQNNMLGHSHHLKSLLAILNPSKMQICQRLIQYHEARGDKILVFCDHIDAIKLYAEKLDRPLIYGGTSTEDARNLLQRFQIDAQKEQINTLFLSRIGDTSLDLPAATVIIQVSSHFGSRRQEAQRLGRILRAKKRSEKGFYSRFYTLVTTETHEITFSEKRRQFLEEDCGYGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZWD3</accession>
    <name>A0A162ZWD3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coatomer WD associated region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_159766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287501.1">
        <property type="nucleotide sequence ID" value="XM_018434057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZWD3"/>
    <dbReference type="STRING" id="763407.A0A162ZWD3"/>
    <dbReference type="GeneID" id="28994963"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159766"/>
    <dbReference type="InParanoid" id="A0A162ZWD3"/>
    <dbReference type="OrthoDB" id="5588835at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16628" checksum="418B5095DC80BD03" modified="2016-07-06" version="1">MGYAWFISRGAEMCDVSEGVSSLPNSATLHKLIYPTETGGKFVLEQIKKYKHEDYHANSWLVKVTSNGRYLLAPTIYGQIFVFNMFHGQLTAILKDHEDVEVRDVIFHPYRPLIFSSGDDGCVKVYSYKNLVTDDIEADLLVGKDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163A2L4</accession>
    <name>A0A163A2L4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cell morphogenesis protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_85885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288681.1">
        <property type="nucleotide sequence ID" value="XM_018443628.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A163A2L4">
        <property type="interactions" value="255"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163A2L4"/>
    <dbReference type="GeneID" id="29004533"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_85885"/>
    <dbReference type="InParanoid" id="A0A163A2L4"/>
    <dbReference type="OrthoDB" id="6287725at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025481">
        <property type="entry name" value="Cell_Morphogen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029473">
        <property type="entry name" value="MOR2-PAG1_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14225">
        <property type="entry name" value="MOR2-PAG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14228">
        <property type="entry name" value="MOR2-PAG1_mid"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="1">
        <location>
            <begin position="55"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="3">
        <location>
            <begin position="675"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="3">
        <location>
            <begin position="1182"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="3">
        <location>
            <begin position="1483"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis protein C-terminal" evidence="2">
        <location>
            <begin position="1694"/>
            <end position="1940"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1940"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD70641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1940" mass="220243" checksum="DC14198B1805CE03" modified="2016-07-06" version="1" fragment="single">LLGKGADPSFDKLFISLASLASSQQKAVIDAVMRWRSEMSAPLSRTREVESVLKERQSLSSVYILCRALIEIVRRFSADTCPESVGENLEEIVFIQLKKPDPDAIKRSANRTASMNLFAELIGELSNIRFASVSDRFIAELEKYNSHTIMKERQSHMEMLIRGMRFLKIKIYPLDALEETADFLSSCASFFKNAHGAKVKHAYANLFVQLLLPIAEVAVAEVNFPAWVKAVDLMYPRALKMTLKPRHILGGYPLVTTLLCVSRKEFFTTNWLPIVESCYQKFNKDKYTRQMAIGCISRLVWTYLFRCTESVSASFKKLDNIIKNIFPPFRRAVYPSEIPLDHFILITYFCLMKDVDTAMKKVTYYLLNTENSNSLHWETINPERVIIGLRAFRMMLSDLEKNVLRPPFPGDPDMTAPGISISCSADVFSGPIRAVKAEVMEQVEEIICKVLISLDQTFGRLLLLEEKNIVLRNITGSGTNTGGGLSANYSVPMFTNGVSMSSTSDGGPQIHHQYATFSVSYTKDKQTYFDVLTTILDSMPRLMPAGIPLPRLVEMLSRYTVHIDPEVIQAASQALLRIAAQIDSQTVVTGYSRFVYRIEDRCCDVLTSLANGPLTGGNYNGNKGVMKLYVDLLAIWAEQVDLSALKDLEMSSNENPNGTSKAQTNLIRLFNMVEETEANGLLFLCSQSSSARRSAIQIIKFAAQLENRLEALLEKEPHHEHLSTLIAQLNNFFSKSQKYGRLYDLLESIGQDLIKFDNDSNVLLGSKISIETRIRIQQHQRRGVKHVLIQIAESDHSADLVIWNICFPKVFKFCFEHFPGTVALCRQNICMRLVQMYPFIMGSLETIKAGPAGTLSMAKSSNSGHKAASPEMVDQWRIYLVFACATATLSEDRSPTATWANSGRKGSTLVDKIATPRDLFRMALKFVTCEHRQIREGAIQGLGNVNKATYKILMTDLQPFVRTVLDDGKQRNNQKPYQNKRSKKHDRLRISLMHLLELTAGCLSEKEHLEDKELMNMMMSYIKETKSFLTDVEVQLEWEYHKLRMHLCGTVEKLYENIMRLEEPTSVMSFETRLGLYKMFEEWCGYGMYANNTRARDAAMMRDVLEQCKDPRERGTMTQILEEERKSLETAALSAMAMLCRGPLYAFLGQKKARQAVIQFDLHNVFRWIDAVFESHDPKCHSIARRALEALLIYNQDQSLLLDDIIEQCYAGNPKLEFTQGYFLAFAEILCKVEDYPCHIHQVMSLALFKAGDSKKAIRKSAIALLRTIEERVFADSCAKEYEIGITSSLPAIYKYTQTLLSARLALDHPEQTYSMLSEISQRFEHISPNSQREVLAYMIPWLRKIDLSVGPQDSELSASAYMVLSNLYYITIKFGDVYVKEVAALWSQLVDHGRNVRAIIMYLLDMGLEKRNPWFLIHAKRVFVCLGRTPAFNRIVEEVIAEITPRSMVPQLKEASIRHTHAFPLLFVADTEKVLPSYEKRPVFSRGQLAMVFLVDLAIEAGADLAPHLPLLLHSIFVQLDHLTSIVCDQSRCLLINLIHSIVIRQSIDSDIPTKATEVTQWLASKEGKRLWAYENITSKNPRLQSSEELKDLLNKVVDVFSHEDPGLRQKWGETALKWATCCSVRHIACRSFQCFRALMPAFNQHMLADMLARLSNTIADKSDDIRGFSLEIIITLTEVTTAMDKAQMDQFPQLFWAAVACLYSPYEAEHSEALLLLEVVLEKYGFCSELAESFPKNWSSEFDGLQPLLLKGLQFSSAEERTFSILSRIMLIDNPPLIDPSETRLMYLLLGSIPRLLHALDDDETLDPSTVELANKMTQLFERYSLPDVQRILATYPKQKAKFQKDYLEQMLGSIRDIFLPKYGKTALMFSILLVKNKMPFYREKGLMMIENLVPYVTGKTNWPGGSNSPIPIDIASLEPLLQLIQTDFGDKALSILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AGM7</accession>
    <name>A0A163AGM7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_21165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291391.1">
        <property type="nucleotide sequence ID" value="XM_018439751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AGM7"/>
    <dbReference type="STRING" id="763407.A0A163AGM7"/>
    <dbReference type="GeneID" id="29000657"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_21165"/>
    <dbReference type="InParanoid" id="A0A163AGM7"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="29"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="447"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD73351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="538" mass="60652" checksum="F75C86A0EAC4C088" modified="2016-07-06" version="1">MIFKSPLPPIQVPKTGLIQYLFNSRKFTTPENKVLFIDVETKKTLTFRQTKENILRFAAGLQDKCGFKKDDILAIYAPNQYDYIIPMLGTIVAGGTISLLNPNYNKTELECYLKMTKPKVLIAFQSNIKVALEAGEKAGILPQDIFVFGEASIEGVQPYTKYLLTDRMATLIEYTEEEAKDSVALLCLSSGTTGKTLNLKYTFYLIHTNLTTSFEQHFETYKYCLYPENHRSLGILPFYHILGLYAVLNETFYHGIPLYVLQKFDFSLFCETIQKEKITRLYLAPPIILRLSNHTALDNYNMSSLEIVHYGAAPVSKELDQKVKDRLKKPVLRQLYGLSEVGLITYVGMVANDKGIVGKLVSNMTAKIVNEEGKEVGYNESGEIWLKGPNVMKGYLNNLAATAECIDSDGYFHTGDIAVIDNDDNVYIVDRIKELIKYNGFQVPPAELEAHLLESPLVADCAVIGVYDEKKVTELPRAYVVLAPDVEASIDTEIMIMKFVADRVVAYKRLHSVFFLKEIPKTTSGKILRKKLLNILAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AKM1</accession>
    <name>A0A163AKM1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_111958</name>
        <name evidence="4" type="ORF">PHYBLDRAFT_144608</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018431250.1"/>
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        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="GeneID" id="28989158"/>
    <dbReference type="GeneID" id="28992156"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_111958"/>
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    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
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    </dbReference>
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            <end position="340"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OAD74151.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OAD74153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="345" mass="37814" checksum="1861ECCFFD943434" modified="2016-07-06" version="1">MVSNTQIIFSKIPTTFPEVGEHMTIKHDTIDLEAELPENHYIVKTLTLSVDPYMRGRMRAAGTKSYSPAFDLDKPMAGHTVGVIVKSNNDKFKVDDIVYGIGHFAEYTHVPAQLAFLFTPRNEARESGLPLSNYIGVLGMPGMTAYVGLIKFGKPKKGETLYVSAASGAVGQLVGQIGKVLGLHVVGSAGSDEKVAYLKEIGFDGAFNYKTEDTNAKLTELCPNGIDIYFENVGGKMLENVINHSNNFGRIVCCGMISQYNTTNPEPIHNLIQIVSKRLRIEGFIVGEHPEMEADFRKDVTQWLKDGVIQYRETAAEGIESAPQALIDVLKGKNFGKQVVNIASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163CS44</accession>
    <name>A0A163CS44_PHYB8</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_184188</name>
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        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
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                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OAD65200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018438899.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28999805"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_184188"/>
    <dbReference type="InParanoid" id="A0A163CS44"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="85" mass="9973" checksum="1ABA0311204FED78" modified="2016-07-06" version="1">MTATPLNIDEGTFSISNRPIASMVQSYIHMQPEVEYVLSSVVEEKARRHISYKIHRAKSMSEKLAGRNRFSRCRTRKIRECHFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163CXU7</accession>
    <name>A0A163CXU7_PHYB8</name>
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        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_70851</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441003">
        <property type="protein sequence ID" value="OAD66390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284430.1">
        <property type="nucleotide sequence ID" value="XM_018442349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163CXU7"/>
    <dbReference type="STRING" id="763407.A0A163CXU7"/>
    <dbReference type="GeneID" id="29003255"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70851"/>
    <dbReference type="InParanoid" id="A0A163CXU7"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="78"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="395"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="467"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="622"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="418"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="499"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="546"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="622"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD66390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="766" mass="84442" checksum="8ECBD1DFB925ACE6" modified="2016-07-06" version="1">MLGAAARFVECESHSQRSKVYRPPDTAWDVPLGWSDQFFDKAQALISASAAHPTLSKVQAVILIHNHSGNMDSKSSACWLMGGLAIRLAQGLGLNRNCEEWDISESEKQTRKRLWWALYVTDRFHSASLGRPISIRDEDNDVGYPDATASWREVLDLPKELDGKEITRFPSATYQPASIEGRVEFYQLFVQLVKLSEILGRILQGLYTPKAQKVSHDHGSDAIVSMLDHELTEWRFAYPKALESAHFDDFNEKDGYLAPVSASILLCYFSLLILLHRPFIERISPGKTKARPSYSSFRIGTSAATRGMRIASQMKVRDFLMFPYSFGLYPVLQCCLIHMYNTKNPDIRISSPAMSDLAKGLALVERLQEMSSTARRLHGLLSIVMSNKDIEVGKPAAVDHSDDRKNSIQRQTEVEPGSLSLSSSLSSSSAVAASPSPQLPTSSPSALSSSRPATMRVSDVGRGILRQTQHQHQQHQHQQHQRQRQPSNSSWISSVHNMNPPPKSLSHPLPPQSMPYTNNNNSSNSNYMYSQPGLSETMISPFDTHSATSTPSPTSTGEAFTLKQFGFNIPGEQNMADLDSYQQNMSIFSGIDFLPSFSMYPPFGNEPRSLEINNVTGQNNVSLSSSTTAATTVQSTLNQHSSSSPTALSSESLPSSSSSSSLIISRPTTDQLDITTTSHNTSNTTTTTTTTTNNNNSDTGSGTGSGNNNSNNSMVSGIHGNQDLSNNVFRNNPNNPFWGIPSSMDWTEWNEWNQRTQGSATWQPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163D060</accession>
    <name>A0A163D060_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_72160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285790.1">
        <property type="nucleotide sequence ID" value="XM_018442608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163D060"/>
    <dbReference type="STRING" id="763407.A0A163D060"/>
    <dbReference type="GeneID" id="29003514"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_72160"/>
    <dbReference type="InParanoid" id="A0A163D060"/>
    <dbReference type="OrthoDB" id="2276543at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="148"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD67750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="280" mass="32459" checksum="29AF4271C13751EE" modified="2016-07-06" version="1">MALLVRKSSFYKLYDLVKIHELYQQLSGFYSIDVRLQISIVLDRLGSNGNSLSSDHLARHSGIGKGSIENITIRFFKVILSLEHKFIYWPTKSEKAEIKRANEYLLGFPNLVRYLDGCLFKLAKALSWKPEQFFSHRSAYCVNNVACELGKFPEQFFSDDEYVLADVGYKATNYIVPIKKKPRNSELSLADQEFNTKISSMQVKIEHAFGILKERFYYLKSIPKAKRRWEDREKSEVARLRKTEYSEESGVVDGSQIIDGNTRWIQTQHVVMSKEKNKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DIS0</accession>
    <name>A0A163DIS0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_170189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289560.1">
        <property type="nucleotide sequence ID" value="XM_018436281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DIS0"/>
    <dbReference type="GeneID" id="28997187"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170189"/>
    <dbReference type="InParanoid" id="A0A163DIS0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="157" mass="16894" checksum="E879668C4DB06A10" modified="2016-07-06" version="1">MDVCRTITYVLLLSSTGDSSSPSLRKHKDRHPEILKPIKSNSSSGCSLLKVSNQDVSLVRCKTTPQWAAVTLWVESTQLLGCPWGEGRGMVLPPTTGCKQFTSGGLSQTGCSVAASLPSNLASNLASSWTYAVSSITSQRFNCTMSSNDIFRTVKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DKP2</accession>
    <name>A0A163DKP2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_169871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD71960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290000.1">
        <property type="nucleotide sequence ID" value="XM_018436186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DKP2"/>
    <dbReference type="STRING" id="763407.A0A163DKP2"/>
    <dbReference type="GeneID" id="28997092"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169871"/>
    <dbReference type="InParanoid" id="A0A163DKP2"/>
    <dbReference type="OrthoDB" id="2286841at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF34">
        <property type="entry name" value="NOTOCHORD-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="468" mass="53721" checksum="2525B76D4EDE32D5" modified="2016-07-06" version="1">MSLLPAIVNDFKKLEKGVKMFSAEDNEHAKDFVKDLSYFCECHERRTREHYVLANSSPGRDTEIPNAPKIGMNTPANEISFRDHSTGHLLELQSFDPEKNTPVEILHTILLGVAKYIVIDLVKVVLKNDTATIARLSEFLTDYTRSTGLSRKFTQNLRHSSSFFSRDFKVLLQILPVILITEFSGNHELDLVISCFVELGQLCSLLFVCQVTSDFDNYIIRVDNTVKRLIRALFDYNKETKNELHKAYCTKLKVHYLTHLKKDIICFGPALNYETEKGKQFNKHICKHLFHTNHQNTSRDICLKFAKQVTLQHVIDGGSWINSSGNQEKSGTRIERFIKDNNESLFYYTFFGGSRELKDNNDTGDIEDDAVQNNSFGAFVFKDYSISRPCIGLVSGSVVKFLSIVPCTDNDRNNNYAKAVMTDEHSDVANMNLICKLDLHIFRNLFYIVNLSKFGSYWFIFNNILFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DL18</accession>
    <name>A0A163DL18_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_169944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290080.1">
        <property type="nucleotide sequence ID" value="XM_018436219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DL18"/>
    <dbReference type="STRING" id="763407.A0A163DL18"/>
    <dbReference type="GeneID" id="28997125"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169944"/>
    <dbReference type="InParanoid" id="A0A163DL18"/>
    <dbReference type="OrthoDB" id="2288646at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="140" mass="16533" checksum="AFE0592EA09E448F" modified="2016-07-06" version="1">MPIQKFRKSSRGSYRPRKEEKYWGVFYLLKTDLTLREIAAIVEMKLPSVQTVKKRIQVYGNPLPRKSTGAPRKVDERTERHLERIVREDPFTSYNQLRKALSSMSINICRNMVIDYVKRLDFKSCISAHKSRLTEEQKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DQH4</accession>
    <name>A0A163DQH4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_146183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290900.1">
        <property type="nucleotide sequence ID" value="XM_018431602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DQH4"/>
    <dbReference type="GeneID" id="28992508"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146183"/>
    <dbReference type="InParanoid" id="A0A163DQH4"/>
    <dbReference type="OrthoDB" id="2286520at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="262" mass="29547" checksum="782D64C3E087FCED" modified="2016-07-06" version="1">MSSLPSLVSGPELVAIPLHIVKQQRRQCLICLRKDDPPDELERPIGPQLIQATGPEWARVCPCPREAHVNCILSTATDLHCETCQHTYYRQWRVLVAHIVCFASHVFSIGSAIGIAFGLVYLGRGLGQLGLGNEMSNKIDDDPWFDHELGVILQWLDLVYYATGFSGEALLGLVYIFGFCSVAGFDETLLMVNNTLSLDLSWCLGLEYPIWFNRGLAYLILGFIGLLLGTYLMFYTWIWACLFHQIRHAAFQQSHVKPNRDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DTH8</accession>
    <name>A0A163DTH8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_65914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291350.1">
        <property type="nucleotide sequence ID" value="XM_018441554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DTH8"/>
    <dbReference type="GeneID" id="29002460"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65914"/>
    <dbReference type="InParanoid" id="A0A163DTH8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="652" mass="75551" checksum="E91A637FAC2D5DC7" modified="2016-07-06" version="1">MHCYGPKAPYIQYSDLFRYLPNLKRLDLESITYNDIQAAISASDKIWKSLESLNITYGDTDEIQPEKNVLQFINTCSSLKELEIRYRDRGYRIELTVNDFDKMHRNLQNLSSLKAEIYLSFDFPNKLNTVPNTIPALSVTSLDINSKMHDDGREEEEEENEDDDYDDEIESENENVNEWNPWWLYYFGYKYPNLRSLKLEAKGIRGDTITSDATTDREIDCSHPMDVSRILESFSGTLESLSLTGFTYSQRNQYTIQEMSSYCPFLTNLYISGSSFCLNLDNLLDKCVALKQLEFSGARLFLSQGTTAEEPEQQQQHGLRILTLNKCSVAAEVFNHVSLRCRSLEQITLYTLRIIGSICEKTGCLLFDMSHISLKTLNIGQVQYATSYEEIRDDKNIGLTLLSWLKDIPLSDKKNEKEKKDVDTKSLVNSSHGTGWFYTYWRIGYNTLPRVDTLILPKKEADIALEYYQDFQSSKARSTLSHDIFYNLDYPGLDWKHKLYKGYVEWRFGKIKDRPVVCEADDDPKTKSETYFFNFCRDLEVDLNTGILGKRLCEQLPTGRSELGQLPQKNRNKHYYSEIKIGLISSNDKEALYNQYQFLLGFGLTVELKGAAWRQSKGFLRKLVSIKKIRVNNKAFFFLEPNSLIYCHIVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DXW9</accession>
    <name>A0A163DXW9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Polyadenylation factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">WD repeat-containing protein 33</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">WD repeat-containing protein of 146 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">pre-mRNA 3' end processing protein WDR33</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PHYBLDRAFT_19466</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Essential for both cleavage and polyadenylation of pre-mRNA 3' ends.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the cleavage and polyadenylation specificity factor (CPSF) module of the pre-mRNA 3'-end processing complex. Interacts with CPSF3/CPSF73.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the WD repeat WDR33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292150.1">
        <property type="nucleotide sequence ID" value="XM_018439704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DXW9"/>
    <dbReference type="FunCoup" id="A0A163DXW9">
        <property type="interactions" value="147"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163DXW9"/>
    <dbReference type="GeneID" id="29000610"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_19466"/>
    <dbReference type="InParanoid" id="A0A163DXW9"/>
    <dbReference type="OrthoDB" id="16717at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000069">
        <property type="entry name" value="WD repeat domain 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000077">
        <property type="entry name" value="WD repeat domain 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000085">
        <property type="entry name" value="WD repeat domain 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="5 20" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="20">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="20">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="20">
        <location>
            <begin position="158"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="20">
        <location>
            <begin position="200"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="20">
        <location>
            <begin position="242"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="20">
        <location>
            <begin position="284"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="20">
        <location>
            <begin position="328"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="354"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00063159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00068823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00075792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00076133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OAD74110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="410" mass="47380" checksum="2D79B9BA31DE2ABD" modified="2016-07-06" version="1" fragment="single">MVFDGKRMRKAIQRRTVDYNHSIARWMQERVWIRDRRDIRYLRPDDNFVVGLLAPAGYLDHPVNAVTTKFVHTSTNKVRFPVNVVRWTPEGRRLITGSSSGEFTLWNGLTFNFETILQAHDSAVRAMNWSHNDDWMVTADHSGVIKYWQSNMSNLHKFTGHNEAIRDLTFAPSDTRFATCSDDSLIKIWDFNTSKEEKTLTGHGWDVKCIDWHPYKALLASGSKDNLIKLWDPKTAKNITTLHGHKNTVLALEWNQNGNWLVTAGRDQLVKVYDIRMMKEFQIFRGHKKEICSAKWHPQHERLLATGGSDGSLMFWLTGQDAPIGEQELAHENHIWSLDWHPVGHILVSGSNDHTTRFWTRPRPGETNDDKFDSSQHRNDEPEKNEEESRSFAEPPPFRPHGAPGPSRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EEJ7</accession>
    <name>A0A163EEJ7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminoacyl-transfer RNA synthetases class-II family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_71715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296280.1">
        <property type="nucleotide sequence ID" value="XM_018442530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EEJ7"/>
    <dbReference type="FunCoup" id="A0A163EEJ7">
        <property type="interactions" value="516"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163EEJ7"/>
    <dbReference type="GeneID" id="29003436"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71715"/>
    <dbReference type="InParanoid" id="A0A163EEJ7"/>
    <dbReference type="OrthoDB" id="439710at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00777">
        <property type="entry name" value="AspRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04317">
        <property type="entry name" value="EcAspRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="entry name" value="GAD-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047089">
        <property type="entry name" value="Asp-tRNA-ligase_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047090">
        <property type="entry name" value="AspRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001750">
        <property type="entry name" value="PRK00476.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="7">
        <location>
            <begin position="212"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD78240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="662" mass="74371" checksum="A5513C4792E9154B" modified="2016-07-06" version="1">MTSRIKSLATITARANVLLHQSLRSSIQCRVPITARTIPRRTFRTTGIYRDQHLQGYKDADRYHGDYPTRTHRCGELRASDEGKRVVLNGWAQSSRALSQDLIFLPLRDASGTTQLVYRTGQQAAELRSQIQGLGAESVICAQGIVRRRPDGMANAKQGTGEIEVEIEKLYCLNPASPNLPFWPNQPQLPNEEVRLRYRYLDLRRQELQDNIRLRSLTAATVRQHLVSNGFVEIETPMLFKSTPEGAREFIVPTRKKGAFYALPQSPQQHKQMLMAAGFDRYFQIARCFRDEDLRADRQPEFTQIDLEMSFVTPKDIQHIIEGMVTSIWDKALGVKLTKDSFPHMTYAEAMTNYGSDKPDVRFDMKISEIGSSFADVVGDNALDCMVIKQGTSLSGKELKAMQKTLDIENEKGFAFVKINENNIDAWPAKCGGTLRQSTQIATSVPGLNKDLGIEQGDLVIVHTRPRYLYGGNTLMGRVRLHAASLMQEKGLLKLDKEKFKFLWVESFPLFTPDEQGIRTWQSTHHPFTAPFNEDIALLSTEPAKVRGQHYDLVLNGMEIGGGSIRIHSPVMQTYIFEKVLQLEKHEYSRFDHLIDALGGGCPPHGGIALGFDRLMAILCDAPSIRDVIAFPKAAGGKDFVVNSPSEVTTGQLEEYGLRLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167J7H5</accession>
    <name>A0A167J7H5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_176146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441028">
        <property type="protein sequence ID" value="OAD65378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283418.1">
        <property type="nucleotide sequence ID" value="XM_018437671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167J7H5"/>
    <dbReference type="GeneID" id="28998577"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176146"/>
    <dbReference type="InParanoid" id="A0A167J7H5"/>
    <dbReference type="OrthoDB" id="2280749at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="236" mass="27140" checksum="29355D835A7C354E" modified="2016-07-06" version="1">MLKAAYVQKRPQSSINIEVDESVFADLNKNKTRRLSEKRRFDKILSVEERLALSSIKISNQVKLPEYQLPNNSHSLIKNWKKALNDKVDVFLQKPPPTNREEMIIANILSTLDTSSFSLLEGVPKEYLTTRPDIIIICYERVEVGCGEVKPPKKSRDLIDIDRARIAEICKRQLHLRLQTSSSTKEHCTFGILVGEIGMLLMWYFEIEKKYFIDYDTERLSLNLFGVGHLGALEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JE70</accession>
    <name>A0A167JE70_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_71663</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0507 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441027">
        <property type="protein sequence ID" value="OAD65816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283856.1">
        <property type="nucleotide sequence ID" value="XM_018442521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JE70"/>
    <dbReference type="STRING" id="763407.A0A167JE70"/>
    <dbReference type="GeneID" id="29003427"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71663"/>
    <dbReference type="InParanoid" id="A0A167JE70"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097422">
        <property type="term" value="C:tubular endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051248">
        <property type="entry name" value="UPF0507/Ank_repeat_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G09870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="4">
        <location>
            <begin position="17"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="248"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="522"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="181"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="187"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD65816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="879" mass="99169" checksum="B367250D2A6DF9D1" modified="2016-07-06" version="1">MEQIYDVLFFKITQQELAEDTALSEAVDSMFQLDFIQVGLPPILGAKKRVTQAIAEFERIGSYRTPADKLDSLLTTISRLTDGIMSDSQQGLDSDSLIPLMLLTIIRSRAPHLRANLNYMKDYSFERNTVTGQYGYALITLESVLDYIIDAHRPLSEIARENQAFWTALDQGNLDRVKKVTADERSTQPQPQPQLLSSSSSSSISPHLPSSSSSASISASRRTSSSNLSIARSCLLLSNTIYDARDHKGNNALMLACRGGHVQTVEYVLSVREPINAQDLNDSKETPLMMALEAQSIKTVKLLLKDPFVVATIDHVSDTQKTSLILASRIQDPVFVKLLVGADLDVVNLGANGPSFSPSSSLLSQEHITKALYAACLANCSDVIRYLLKFNPRLDLPNDRGETFFHLCRDSDIVRELLSVLSKPDLTTNDTLIQSCVDALDSQKRTPLLVWAAKGRPDLVELFVPVANPDRLDCQGRSGLHLLSMVRWTIPANTNSKFVLSRCIHDLVKKLGHLMHLADWADGNTAVHLAAQTMNLRPQVWITELVRQGADLTRVNRFLDRPLNLWRGTDRSFLQDTVVPTLDHLIEPLLLLSPRLLEDAVQCLDRMLAWLFFHPLLRHTHILHAFVRLPDLKRDVFAHHAFVRRQLRSQNVESSVQEKGEDYFFKYARQMLLPLRDSLGKVLHQSRQVELCIRGTEVSRRVVANDLKTMSLGQPELREMLNIVSLCCNGTYSPWVEFIGIVQNMHSLASGVLLALEYPLCLIDQQTELRTHLERQRDALQHHKAWTLFSQENKQLNHEKTKVVETLGAVEKTSCEIGDSHQRISDELAHFQTIQPRYISRALGRLARQQFEREKVNLKVLLMAMNDLKCVSKEEPPKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JTK1</accession>
    <name>A0A167JTK1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_97704</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KV441001">
        <property type="protein sequence ID" value="OAD66679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284719.1">
        <property type="nucleotide sequence ID" value="XM_018444030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JTK1"/>
    <dbReference type="STRING" id="763407.A0A167JTK1"/>
    <dbReference type="GeneID" id="29004935"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_97704"/>
    <dbReference type="InParanoid" id="A0A167JTK1"/>
    <dbReference type="OrthoDB" id="2649at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000770">
        <property type="entry name" value="SRSF protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000275">
        <property type="entry name" value="SRSF protein kinase 2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="46"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="198"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD66679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="443" mass="50817" checksum="E52E8DC0E44E66E1" modified="2016-07-06" version="1" fragment="single">TQEDDGSSEHSAVYSIHTEDEEDEHEYQPGGYHPVSFGDQFHQDRYKVVRKLGWGHFSTVWLAHDKEKNMYVALKIVKSAPRFTQSALEEIKLLEKVKETNKEAVGWNHIAQLLDHFWHQGPNGKHVCMTFEVLGESLLSLMKRFNHRGIPSAMVKRITRQLLLGLDYLHRECGIIHTDIKPENVLLWIPNVQSYLGHPSQPSDNQQQVQQSASSASLLNQTSPGSTKSRKRRVKRRIKKQQARATVSLHEECPLPLEPSLVLPSSVLDILLVHPEALDRVVVKLADLGNACWTSGDYGHVIQTRQYRSPEVIVGARWSERADMWSLACMIFELLTGEFLFDPRGGSKFSKDDDHLAQIIELMQVVPRSLTTLGEYSREFFGKNGQLRNIKKLRYRRLRDVLHDSFLLPPSEADLLSHFLSPMLQVEMEKRRAAKAMLDHQWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JTZ9</accession>
    <name>A0A167JTZ9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_183794</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441001">
        <property type="protein sequence ID" value="OAD66707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284747.1">
        <property type="nucleotide sequence ID" value="XM_018438834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JTZ9"/>
    <dbReference type="FunCoup" id="A0A167JTZ9">
        <property type="interactions" value="328"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167JTZ9"/>
    <dbReference type="GeneID" id="28999740"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_183794"/>
    <dbReference type="InParanoid" id="A0A167JTZ9"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="41"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="447"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD66707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="661" mass="73267" checksum="EF214F28687FADFC" modified="2016-07-06" version="1">MALNDTSPTDPIPDEPLEEEMYTSWALLILMTLLIGALWTSYYLQQRKIRAVHETVISIMAGMIVGLIIKLAPGTIIQRMVQFNEGYFFNLLLPPIILNSGYELKRRNFFLSFGTILTFAMVGTLIAAIVTGVLTFGWAYFHPEGIHISFLDSMIFGAILSATDPVTILAIFHQLHVDPQLFAIISGESLLNDAVAIVLSDTLRKFRGQELHVINIFKGIGLFLGVFWASTCIGILFGLAVALMLKHSHLYQFPNIEACMISLMAYSSYLFSNAAHMSGIVTLLFTGITLKHYAYDNMSLRTKRATKYVFQILSQLSENFIFIYLGVNLFTETDLDYKPLFILFTTLFICIARYFSVAPLSMLINAVCRALGKPEQLPQSHQVMLFWAGLRGAVAFALASNLGGESAAAMRTTILAVVVLTVLIFGGTTGRMLQILEIQTGVLEPEDMASDNDNEADNTNNSHEEGGLSLGGRPSRRTRRSPSTDRLLDTDEDEERVIHGNSSSGDGGGSGSDRYRNDPTDVSIGGLLSGPIGDPIPDPGPPHWFMSFDEKWLKPFFTKRHVQQRNQTLAEYWKDRRRKMDRANQNMLAGIRNMSLGTTSGRLVNDNDNDDEDDDALTLHSVYPVEDRFDGGDLARTPSNNGSRLVIGAGRVFGRSVSNQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JW44</accession>
    <name>A0A167JW44_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_174825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441000">
        <property type="protein sequence ID" value="OAD66799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284839.1">
        <property type="nucleotide sequence ID" value="XM_018437351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JW44"/>
    <dbReference type="STRING" id="763407.A0A167JW44"/>
    <dbReference type="GeneID" id="28998257"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174825"/>
    <dbReference type="InParanoid" id="A0A167JW44"/>
    <dbReference type="OrthoDB" id="2262863at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="319" mass="36323" checksum="9F3D04E60FAC7687" modified="2016-07-06" version="1">MANSTDKRETIMPDVLKTNTSVNARALSFVNHLSGCLLELKAFDLSKNTLVQILHTILIGTAKYLINELVKEILKPYPGKLKRLANGLKEHNILTGLSRKFTQLLRHSGSFLGRDFKMLLQTLSVVLLRDFSNDKIIDPILQVESKFEKYIVQVKYAVNSLIVKLHEFDMANVENPKHLPLSTKLKTHSMTHLTEDIRQFGPVLNFETEKDKQFNKDVCHKFAKQKIMQHNFANGSWINSNRQGEYSGPGIAEFIKSNYDKDKTFYNLFLRESQVLTDNNDTSNITTLKDNFFSAFVIKNSIGTTLSIGLISDSMTTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K2F0</accession>
    <name>A0A167K2F0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_151731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441025">
        <property type="protein sequence ID" value="OAD67127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285167.1">
        <property type="nucleotide sequence ID" value="XM_018432734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K2F0"/>
    <dbReference type="GeneID" id="28993640"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151731"/>
    <dbReference type="InParanoid" id="A0A167K2F0"/>
    <dbReference type="OrthoDB" id="2404451at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="446" mass="49814" checksum="5FCED79F6CD1B9AC" modified="2016-07-06" version="1">MNMFLYVINPTSECLDHHTYHQLQNHKRGHESNLASANIISQYIAEDVEMQNDIRNDIIDNNELVNDSDNNNQYYAVNAIEIDEVISYKCSCSFEDSEGEAHIYDSSRIDSNTFTKAKLMNHNEVMLEPGAKISHGKTVDALLKSKSSVKGHEYDVCLNGCQLYGINDDQESCVDCDELQYKTDTEQSQTPAASMKLMSVGDMFSQMLADSATRELLHYRANWESVAGQLTNIFDGKNYKQLVQQGLFSNPNNIAIGLYTNGFVNQKKGKSSYTIVHAVLAILPGPKKPTHLDSFLGNGVEVCRAKIHLLLASGDIPAVADMTNIGSHASLFGCQICKTKGKASENRWHGIYFEDSSAPLRPLEDFKTGNPIKNVYQPSIFSELSTFFASSFFALDELHLVARGIGKHIYDLITVSLTKETKIFIPVRMIPSPPQNTHFSYQELVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K902</accession>
    <name>A0A167K902_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TATA binding protein interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_86119</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285548.1">
        <property type="nucleotide sequence ID" value="XM_018443634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K902"/>
    <dbReference type="FunCoup" id="A0A167K902">
        <property type="interactions" value="736"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167K902"/>
    <dbReference type="GeneID" id="29004539"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_86119"/>
    <dbReference type="InParanoid" id="A0A167K902"/>
    <dbReference type="OrthoDB" id="6260732at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057978">
        <property type="entry name" value="TPR_DAAF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25782">
        <property type="entry name" value="TPR_CAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25757">
        <property type="entry name" value="TPR_DNAAF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Dynein axonemal assembly factor 5 TPR repeats" evidence="5">
        <location>
            <begin position="13"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="4">
        <location>
            <begin position="1060"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD67508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1207" mass="134957" checksum="D7EC2EE96D05D437" modified="2016-07-06" version="1" fragment="single">NIQLMKLCVQMCNEDRDFRYMALNDLMNELQKPSFTLEKSVEIKVVRAVLKLMDDKNGEVQNLAVKCLGPLVKQIQEEHIIEIVKCLCGFAAQRENEELRGIASVGLKTVVLEVNSVKGDTISNVLVPKALEILQDSNTTYEMEMDALDVLAEVLSRFGAQIPASKQAQVKSTLLPLLAHPRAAVRKRTILAVGHFAVHANDAMFKDLITHILTQLKNKSSTGDRLRTLVQCAGMLSRYSTARLADYLPELVSIIEVYTAEAEEDDEMREICLQTLESFVLRCPHKISPYTDRIISLGLEYLRYDPNIDEDMEEDEEEDEEEEEYDDIIDYSDDDDDMSWKVRRSATKVLAAVIETRSDLLQQLYKNVAPALISRFKEREESVRSDILQTFIVLLRQTSLYGGENTEIVIDDGKALLRQLVPKLSHALAQQLGSKSTQTRQIGFHLLRELVTVLHGGLDQEVEIFVPVIVSSLSSSASEQQQVALTSNLKIEVLAFLRRFLRSHPPNVLHPYLDRLCPAIINTLSDKFYKITSEAFLVCVELIKVIRPIHRTETGEHGITPMNEEYKPYLLQILDATLKILSTNDADQEVKERSIMCLGALLAQAGDVLQSQQRQAWDVLLDRLKNEVTRLISVRTLAIVSQSPAVAGEELERCVLVAVDEIGLLLRKSNRTIRIASLECLNILVKRFGQSLSPESCKSLLVELKPLVCDNDLHLLPLALKAIESIITVSASSAENMRVSILPSLLQLIQSPLLQGYALNSLLSLFTALTKACPDEYQNLVKGLVEPLLNVKTSGVSAGGVAAVANKQAAATVAQCVAVLTVNTTLENRQLTIGTFQNYIEDPATNDSIKYLSLLTLGEIGRRIDLSHLGNIHEQILALFSVQSEEVKFAAAFALGNMSVGNISRYLPLIVDQMKAYPKRRYLLLHALKEIITRYDQHGKNASLGDASNEIWDLLLESSESEQEEGTRTVVAECLGKLALTDPRKFLPQLEERLSSPSAHVRATVATAIKYAVVDPSQAYDDLLKPILSQFLILLQDPDLNVRRLALLAINSAVHRKPYLIRDVLGQLIPLLYEETVIKEELIHTVEMGPFKHKVDDGLEIRKAAYECMYTLLGTCLDKIDVHGFLDRVRAGLEDQHEIKMLGYLMLIRLSKIAIRAVTQKLDDLVSPFKSTLDFKMRSNAVKQEVEKNQELVRATLRCIVALSGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KK60</accession>
    <name>A0A167KK60_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_173285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286319.1">
        <property type="nucleotide sequence ID" value="XM_018436988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KK60"/>
    <dbReference type="STRING" id="763407.A0A167KK60"/>
    <dbReference type="GeneID" id="28997894"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_173285"/>
    <dbReference type="InParanoid" id="A0A167KK60"/>
    <dbReference type="OrthoDB" id="2425169at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="30559" checksum="3B3F4B2A7B3907D0" modified="2016-07-06" version="1">MIDCSPIEIGALEEVFGGSVDTLLCHWHIKRAWEVNVKKHIKVQNLTQTSNIACNSVHAVLSNLMHAETSQVFDVSYSEFLEKFEDSGFPRRHFSSAIFHTNNYIESYHNQLKTFYLGRARSLCIDRLIYLLAKVLTLDYRQKNVKTLYGFKAMHLSHQEELKKKKTYMLDIDKATSMNLSSAFSSSSSVQPPSNETSAVVDPSILSDEIAADIDKYIQLYSAELKKKVVEYKGRPEDLGQFVDPLKSAYNKLKEHGTPSQSRPPRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KPY9</accession>
    <name>A0A167KPY9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Heat shock protein 70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_188605</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286648.1">
        <property type="nucleotide sequence ID" value="XM_018439533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KPY9"/>
    <dbReference type="FunCoup" id="A0A167KPY9">
        <property type="interactions" value="578"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167KPY9"/>
    <dbReference type="GeneID" id="29000439"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_188605"/>
    <dbReference type="InParanoid" id="A0A167KPY9"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000021">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="616"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="617"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD68608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="656" mass="71164" checksum="BEF1481ECC4867C2" modified="2016-07-06" version="1">MSEGKAVGIDLGTTYSCVAVWQNDRVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPYNTVFDAKRLIGRRFADSEVQSDMKHWPFKILDKEGKPIIQVEYKGEAKTFTPEEISSMILIKMKETAEAYLGTTVKNAVITVPAYFNDSQRQATKDAGLISGLNVQRIINEPTAAAIAYGLDKKVEGERNVLIFDLGGGTFDVSLLTIEDGIFEVKATAGDTHLGGEDFDNRLVNHFMQEFKRKFKKDISGNARAVRRLRTACERAKRTLSSSAQTSIEIDSLFEGVDFYTSLTRARFEELNQDLFRNTMEPVEKVLRDSKIDKGSVHDIVLVGGSTRIPKVQKMVSDFFNGKEPNRSINPDEAVAYGAAVQAAILSGDTSEKTQDLLLLDVAPLSLGIETAGGVMTALIKRNTTVPTKKSEIFSTYADNQPGVLIQVFEGERARTKDNNLLGKFELTGIPPAPRGVPQVEVTFDVDANGILNVSALDKTTGKSNKITITNDKGRLSKEDIEKMVNDAEKYKAEDEAATARISARNGLESYAYNLRNTLSEEKVAAKLEAADKEKLTAAVDAAIKWLDESQEASKEEYESHLKSLEEVSNPIMTKLYADAQGGAPGGMPGMPGGAPGGFPGGAPGGFPGAGGDAGPTVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L1Z6</accession>
    <name>A0A167L1Z6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAD-superfamily hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_116638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287448.1">
        <property type="nucleotide sequence ID" value="XM_018428533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L1Z6"/>
    <dbReference type="FunCoup" id="A0A167L1Z6">
        <property type="interactions" value="282"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167L1Z6"/>
    <dbReference type="GeneID" id="28989439"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_116638"/>
    <dbReference type="InParanoid" id="A0A167L1Z6"/>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF4">
        <property type="entry name" value="CAT EYE SYNDROME CRITICAL REGION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="37012" checksum="B5A9EA7EE6BC3D01" modified="2016-07-06" version="1">MKPNYAFAFDIDGVLIKGKQTIPEAKRALRLLNGDNAAKRHVPFVLLTNGGGVTEAKKAEQISQMLDIEIRPEQVILSHSPMRLLVEKYKDKQVLIVGGVGNSCRDVAKGYGFENILTPDDIQQWNPSVWPFTPPKFDNPVKHDVPKMPIDAVMMFHDARDWGRDLQIVLDAVCAQNGVIGTQKIDFTAQQIPLYFSNVSKIWSTDFPAPRLGQGSFKVALEQLYETLTEQKLRSTSFGKPHGTTYAYAEHVIKNLSPGGCAEDTKPRVYAVGDNPAADIKGANAYGWTSILVRTGVFTEPGNSSIYPADAVCKHVQEAVEWAIDQEENRANGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L4C0</accession>
    <name>A0A167L4C0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_188297</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LU7TM family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287607.1">
        <property type="nucleotide sequence ID" value="XM_018439479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L4C0"/>
    <dbReference type="FunCoup" id="A0A167L4C0">
        <property type="interactions" value="458"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167L4C0"/>
    <dbReference type="GeneID" id="29000385"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_188297"/>
    <dbReference type="InParanoid" id="A0A167L4C0"/>
    <dbReference type="OrthoDB" id="19932at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053938">
        <property type="entry name" value="PTM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21902">
        <property type="entry name" value="PTM1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007889697" evidence="9">
        <location>
            <begin position="51"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="PTM1-like N-terminal" evidence="11">
        <location>
            <begin position="63"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="10">
        <location>
            <begin position="214"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="496"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="521"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="550"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD69567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="612" mass="69714" checksum="FCF42BD8AA2C89FA" modified="2016-07-06" version="1">MVTLKQTHPSAPSSVVKVFIFSMPRVAAPKWLSGLLLLLLFLTQLLSVHAEEVYLTSDDFYSTTCSGVWSKSAIPGGRTPFIKVTMGGKSHGKTAMLIYEWKDYNNIGYLDNKKQEMRYICDKKAVADKLCTNSTLNEFIVHVPAAEKNTTSILTTVFDMQPDKKEVALYTIENTGYYCVVLVPVGSSGENSTFFEAWVEWKFPYGELPAVDYPKLLFYGIFSLVYLCVGLFWGIQSFRYWQDILPVQHFLSGAIFFLTVEMAFNFGFWEAYNQTGKPCKFIYFILHVVDCMHGIQRRQKLLEYSSIVYLRPSLGSTMKKCVILACTHFFFGVIYSLGTMLLSPETAGFLVLLVVFPLAITMTAFYVWTLGSITQTLATLGKRNKKIKRTSQTEIRRQHVKALMYKRLYRLLVFSVLMVMIIFILNMFNFSDRTQVDWAARNWKRRWFMLDGWLNILYFIVFFVIIVLWRPTSYNSRYGLEQLSQDEEEAIALENSLRRAEGNGTERSGGGRNRSGRSMDGDDALFELGDDFSDDEHGHHKGQVGGNAPSHGNSPASDNRQASQGVSRTNTPKQNANEEESALLHVNQDDEDDEHLDDSEHAHLTANTRKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L5B7</accession>
    <name>A0A167L5B7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_172264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287668.1">
        <property type="nucleotide sequence ID" value="XM_018436761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L5B7"/>
    <dbReference type="GeneID" id="28997667"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172264"/>
    <dbReference type="InParanoid" id="A0A167L5B7"/>
    <dbReference type="OrthoDB" id="2269081at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="AlbA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="257" mass="29094" checksum="D6DAA9014222B409" modified="2016-07-06" version="1">MLNPFAHEFKPIQSDPLPTLPKKAVPDKRKENKRRERKKEDNNQEAITVEKTIEQSSSAQTSFTAKNSSQKSKAKSENIQINASINAKPKPAKKTFPSRQTKPNHSSGPHSSFTDPPFQNSSRRHSKKNEETAINLAPIASVFDTPSKFITIETAIHPVFQMRPEQNIERSQKGHFSGTTSGLTKLDHGYERYIDWIERSLKTFNMITIVGMESAVVDVVSMVAILQQRSIGEHEEVETFSIRDGKRWTCGIQVRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L672</accession>
    <name>A0A167L672_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_149468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287727.1">
        <property type="nucleotide sequence ID" value="XM_018432281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L672"/>
    <dbReference type="GeneID" id="28993187"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149468"/>
    <dbReference type="InParanoid" id="A0A167L672"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="65" mass="6849" checksum="00AF2DD7DA80D633" modified="2016-07-06" version="1">MGVNAEAPGVGFLKNVAALIQDTGAMLDEMLYSKASFSHTAIRSAVSTPSTPHVDEKEKKIGRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L7K8</accession>
    <name>A0A167L7K8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_73397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287809.1">
        <property type="nucleotide sequence ID" value="XM_018442845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L7K8"/>
    <dbReference type="GeneID" id="29003751"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73397"/>
    <dbReference type="InParanoid" id="A0A167L7K8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="140" mass="16513" checksum="ED4B9A928A5D744E" modified="2016-07-06" version="1">MYDEWFRKPTSRVTTTTVFLRIAYEIDTYKFQPEPSKYNNIALYILATYLITQNTQSTQSAQSTSKYSNYCLELSVFEHVYVYSSYCQLIGIFRKDILLTIFTIEIQWGFNRTEKKCTLALCSTGLYHDYQTAFFTDKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L856</accession>
    <name>A0A167L856_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_171817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287839.1">
        <property type="nucleotide sequence ID" value="XM_018436672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L856"/>
    <dbReference type="GeneID" id="28997578"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171817"/>
    <dbReference type="InParanoid" id="A0A167L856"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="159" mass="18345" checksum="5CB6B5F49419736B" modified="2016-07-06" version="1">MFMFEVSYSGKKSMMISVHMNPALRRRNFLALISNCCSICCPSWEWEVIFVLLSALARMRNETSKLVFFLKFYVASELKKDCFQKKKGKENSHRYSAKSGVERVLRYPDCPADFYRPVYSSNVLFKKTLRLVNLDPFPGLPFAEIAFTGPSSVLIFVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LD12</accession>
    <name>A0A167LD12_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_148731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288218.1">
        <property type="nucleotide sequence ID" value="XM_018432143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LD12"/>
    <dbReference type="GeneID" id="28993049"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148731"/>
    <dbReference type="InParanoid" id="A0A167LD12"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="145" mass="16240" checksum="9551A58E2E4DA8A5" modified="2016-07-06" version="1">MACLDSITKSGVYVAYFLPILQINNIVGAGLFITHAPLESLLRALDGGEIQVLSWSEVRFSNLMPISTISNKSHFLPRLELWAAIYEPKLERIRKRNTMSSNLLVNISRSFESFSWLMESCFVYILNSAFDSGQTRVNSGNTGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LG24</accession>
    <name>A0A167LG24_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_171753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288415.1">
        <property type="nucleotide sequence ID" value="XM_018436656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LG24"/>
    <dbReference type="GeneID" id="28997562"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171753"/>
    <dbReference type="InParanoid" id="A0A167LG24"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="223" mass="25596" checksum="5341F1A2D4FEC2CE" modified="2016-07-06" version="1">MSKPVHSKNEILRSNTSLIINPSKLNKYTIFFKNVPSEDCSRLVFSQARLTINVPIFIQDQRHSSLFEHVLTTNSTGMGHMCISFYVPLFITSSLTIGDKYSSLMLIPEVCSSLYLEYNSRISDPSLLEHLRKVLKLLTSEPLLYLMSRVIGYILITIGTIDKITCGNIIQFKPRYLQAQQKSLKACIVATFHKHKYYNSRIHTIILILFAKSEVDRYQDQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LPK7</accession>
    <name>A0A167LPK7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_148075</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit APL3 and beta-type subunit APL1), a medium chain (mu-type subunit APM4) and a small adaptin (sigma-type subunit APS2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288896.1">
        <property type="nucleotide sequence ID" value="XM_018432006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LPK7"/>
    <dbReference type="FunCoup" id="A0A167LPK7">
        <property type="interactions" value="482"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167LPK7"/>
    <dbReference type="GeneID" id="28992912"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148075"/>
    <dbReference type="InParanoid" id="A0A167LPK7"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14833">
        <property type="entry name" value="AP2_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000011">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027156">
        <property type="entry name" value="APS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="11"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD70856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="152" mass="17929" checksum="5FA293AF8F7AFF9E" modified="2016-07-06" version="1">MQANLPGLVLLRFILVQNRQGKTRLSKWYVPYEDDEKVKLKGEVHRLVAPRDQKHQSNFIEFRNYKIVYRRYAGLFFCVCVDANDNELAYLEAIHFFVEVLDAFFGNVCELDLVFNFYKVYAILDEVFLAGEIEETSKNIVLTRLDHLDKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LQ99</accession>
    <name>A0A167LQ99_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_182351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288934.1">
        <property type="nucleotide sequence ID" value="XM_018438604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LQ99"/>
    <dbReference type="STRING" id="763407.A0A167LQ99"/>
    <dbReference type="GeneID" id="28999510"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_182351"/>
    <dbReference type="InParanoid" id="A0A167LQ99"/>
    <dbReference type="OrthoDB" id="2289798at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="508" mass="58868" checksum="8548FCC8F057AC3A" modified="2016-07-06" version="1">MSGKVLQTTPWWNPTQKHFVVLDFELTGKLKELYNLFTGQKHKDTPDELRVKKAVRVSRTNEPDEAHILIVYKSCKARGNSTKRSPVYPNHDMTLLQLLNRDLGPHQRYTLSITLSSFILNNVHVQRARDRIVLQSSFLREVVVLYGRLTIVEFQHHYPRLQHLQTLYTELIQTNEVNLTVNLNGLKNYGAVVSSACKTIAITYNNYYDLSITAIKKIVYEHLLDSLLIRLPAPLQIPDQILPENTTIKLPRLSAFLNKRITPVRNILPTIPVNKATLSRNLQAIMHWRFIKVDSENVKSFFEQGPQKIRDKSSVAYTRRLFFHFFNFKKFKINDIEALINLPNEKSKMFLNSIYTDGYMFRVSFARRTAIDPLNYVELTTNDFNIQEIAENCRVCTVDPGRRDAFKAYYGDDGIRCLTRKEYYSASGSVKRMINEDARKVAQGIKEVGKYIPSVRNSCKAKYLRYFQNSNDRPIHPMKFGVAMVGQKCSILSQVQEQQEQQKHKAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LUI3</accession>
    <name>A0A167LUI3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_78484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289168.1">
        <property type="nucleotide sequence ID" value="XM_018443370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LUI3"/>
    <dbReference type="GeneID" id="29004275"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_78484"/>
    <dbReference type="InParanoid" id="A0A167LUI3"/>
    <dbReference type="OrthoDB" id="2448307at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF1">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD71128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="41938" checksum="52E68E2E17176080" modified="2016-07-06" version="1">MGIISQVFGKSRWTRAIFLCIIVQALLAIIFESVIFSYVANEISIIEQERLNQKGFGESLATAYANARSLLVYFVLFIIAQVFTVILVVDAIYQKNTIQLIALVAFELGMSAYSIIQYHQSLTLFDNTEDASVKLALAFLGSAYHASSWAEITQICVMILSTIVFIFLAYKLYLEFGWHIYNKIGADLAMRDRYKMYQIFMMLLKFDFFFFLGFSIQYLALLIVAWWAEAKTEEAKKSIVNELIEHIVLSCLVSVAMLILAYWGLRKERKPHMYSFIVLSCASMAYFIYMLVQIGQHPERFVGSRAFLTFFLCVDMVLILASVPVAVVCLRNFGFLKTQMPNGNPASPSHSMTPIGKEKPPTERWSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M8N6</accession>
    <name>A0A167M8N6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_159248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290174.1">
        <property type="nucleotide sequence ID" value="XM_018433950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M8N6"/>
    <dbReference type="GeneID" id="28994856"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159248"/>
    <dbReference type="InParanoid" id="A0A167M8N6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007890238" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12645" checksum="3C3D697917E33EC8" modified="2016-07-06" version="1">MFLLSVLIFLVILQFIPTIRLPISIQGYRHTSLLHHLLTAYFICPESSQLMSTVTVLTYISNHSHRHTSLFEPLVTLSCIFPYFLLQRPAIKVSLSIKILSYLNIVKTND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M922</accession>
    <name>A0A167M922_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_147141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290204.1">
        <property type="nucleotide sequence ID" value="XM_018431804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M922"/>
    <dbReference type="GeneID" id="28992710"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_147141"/>
    <dbReference type="InParanoid" id="A0A167M922"/>
    <dbReference type="OrthoDB" id="5537330at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="208" mass="24048" checksum="FAC5468A426A70AB" modified="2016-07-06" version="1">MTLLNNQVYEYLLNIQVKALNSDILICSGLVSKPDHKKDFQFLASRHLESFATNEEKSKWAKIMRSAITKSLIFQGFPTCIHKIINASSDLYEILTPEVKAILKTEVDIYYRNDTTMEELYEKGYGVFKNVYKERSNSVATYMTEQNHDLFNHCLYMYAVVIGNYTHLSVLETHYVMLENHLKNFIDLGGTEEELKDINTIVEAIKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MC49</accession>
    <name>A0A167MC49_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BD-FAE-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_146619</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290469.1">
        <property type="nucleotide sequence ID" value="XM_018431688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MC49"/>
    <dbReference type="STRING" id="763407.A0A167MC49"/>
    <dbReference type="GeneID" id="28992594"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146619"/>
    <dbReference type="InParanoid" id="A0A167MC49"/>
    <dbReference type="OrthoDB" id="6495301at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="BD-FAE-like" evidence="4">
        <location>
            <begin position="122"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD72429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="480" mass="54119" checksum="845B2F5353CB76DB" modified="2016-07-06" version="1">MPLFKSRTIFVSASLFFLPVMVLCAVLCLPLIACIVGAMYLIAWIVYLQLAQTHVEFNLPYNPSRVLKINLIILDLLVGWIYEIPIIVSFIYWRYWTMRNQRFQHIVKRDITYSDADPDCKLDVYSPSASPLGDKKKSPIVVFIYGGSWSSGSKYIYTPLANTLREMGYVVVVPDYRKYPRVMVDEMYADVRQAIKWAYKHASEIHGDPELLYVMGHSAGAHLVSQVVLTDLVDKASYAEAARDRTANHNSHGHNHTSSINSNNSSNSNMSSLISEKHDPSSIIKPMMMAPPHHTTSLPPPSPPLPLYNHSHHPIHGSIYDFLPQVEGLLLLAGVYNIETHLEHETSRGVEKISAMARAMGSSVDGYRANSPTELIRSSQGLFATSTEVIDFMPRILFIHGEIDTTVPKEQSAEMYNVLGEVLSPERRVEVDIRMLFYKSMSHSQCVTAFMPSCLGKDRLQKSLARDIQEFINVPVDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MLK5</accession>
    <name>A0A167MLK5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">uS12 prolyl 3,4-dihydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_97540</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54160"/>
            <dbReference type="Rhea" id="RHEA-COMP:13817"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
            <dbReference type="ChEBI" id="CHEBI:138052"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[ribosomal protein uS12]-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54156"/>
            <dbReference type="Rhea" id="RHEA-COMP:13816"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291244.1">
        <property type="nucleotide sequence ID" value="XM_018444024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MLK5"/>
    <dbReference type="FunCoup" id="A0A167MLK5">
        <property type="interactions" value="440"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167MLK5"/>
    <dbReference type="GeneID" id="29004929"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_97540"/>
    <dbReference type="InParanoid" id="A0A167MLK5"/>
    <dbReference type="OrthoDB" id="430522at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009896">
        <property type="term" value="P:positive regulation of catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000014">
        <property type="entry name" value="Prolyl 3,4-dihydroxylase TPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.20">
        <property type="entry name" value="Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019601">
        <property type="entry name" value="Oxoglutarate/Fe-dep_Oase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043044">
        <property type="entry name" value="TPA1/Ofd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051842">
        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117:SF0">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10637">
        <property type="entry name" value="Ofd1_CTDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="13">
        <location>
            <begin position="116"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD73204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="522" mass="59118" checksum="355B7293A2B2FCE0" modified="2016-07-06" version="1" fragment="single">VQEVFHKGLMDPQNRDRLQKACQESEPYKHCAIERLVNDELLRKVYEEIGASLRFTLKETDIYKVNQTGDLVNMDGLPLEEKNRLRHLFELRNAIYSDEFRSFVSQVTGCGPLSPSKFDMSINTYNSGCHLLNHDDVIGTRRVSFILYMPSPDEEWDPSWGGALELYPVVSKGTPAIEPTVSLPPKWNQFAMFTVLPGYSFHSVEEVVGQNKSRLSIQGWFHVPQLGEKGYETKTTAEKSSLEMLETEEEEEPFVLYKDPLEEQDCALGQEDISVLSEWMNPIYLETKCLGQISERFMDTSAVQLKDILRPDLAESLKKHCLDQDQQDGFTTSNMPPHGSGIHKDWIANGPPVRQRFLRSTSTSNLNGLQSKLQSGAFRRWLATVSQLLPIGCRGMTRRFRPGHDYTLATAHSKGSVLDITLCLATCPTESAAEQWESGEYGGYECYMAPHEGQDDPAIYKASSEDDGALLTMPAGWNEMAIVLRDEGVLRFVKYISARAPGARWDIAMEYEIDQEEEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MN64</accession>
    <name>A0A167MN64_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type zinc finger transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_168696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291379.1">
        <property type="nucleotide sequence ID" value="XM_018435920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MN64"/>
    <dbReference type="GeneID" id="28996826"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168696"/>
    <dbReference type="InParanoid" id="A0A167MN64"/>
    <dbReference type="OrthoDB" id="2262863at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF34">
        <property type="entry name" value="NOTOCHORD-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="947" mass="108533" checksum="3107D168E8C19BD0" modified="2016-07-06" version="1">MNKPRTTLNVNTHLAHFVRRPLKITGILKDICKDAITETVADDMSIVQETEYQDIQTSNSPKNPLTPSESVEEESDVDNEYYNSILNYDECEESDDGSRVDNSDFDVEENTEPNAGIPLFNHILNNMSAFADNNESSIDEEDEFQSEVFNSTAWNRFTPNTHPYKDIQTMILLALVDGDNDMISRRMLKKILFTINLLLKIHEEAIRKDISFKLPRLDALWNYQTRKGSNIPIFKSKSLDVTLSDSTKVTAFLNLPSEHIKLLAADPIKSKSIFSLPDRTPNQSVCLQQGEKWRTNTYFQQPMFTYNNVDFWSGDIILLKDCSPNIRFLVESFHTMDISNVFSRGYIVRTPKDGCSIGIEINHADINIESFLSVDTTPLNTSLCCSISPDTIISLIPTHHKLLEEEHFLKRLICDGTDQENNRRKYYKVKIAPVILFSDDTSGNTSKQFNTYESWSMKSIPKKKGANAASLLPEIVDDLKKLENGVVMFSAKDNAYILVVPPLLWIEADTFCHSELCGLGAPNSTYPCRKCYIKLQSRIPKHSTRTKDHYIQAASTPDRDTVIPDIPYFDDKNTAEELSFKNKSTDKLLELKAYDQSKDTSAEILHYILLGIAKYLITDLVKVVLNKNKKELEELFYYIKDYKNSRGISRAFTRSLTHACSFLGRDFKVLIQILPVILAIKFADTEVLQEITPLFVRLGRLCSLVFVRFIDSQYETYISEVDSAVRSLIEALHKYDTNCKHKKHAFYTSKPKVHLLTHLLEDLRRFGPALNYETEKGEQFNKHIREHLFHTNRMNTSKDICLKFGKNGLRETHGKAIAEYMQQNSDGKFHETLLGGSREFADNNGTGLTPGRILKDNTFALFRQSNGHIIIGMVLFSKVYHLYIEYLSAHAVNNNYRLALKYADDIYMPLDELKVVCLLDMHLKVGCKYVVNLNKFGSYWSFLYSFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MVA8</accession>
    <name>A0A167MVA8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA-intron lyase</fullName>
            <ecNumber evidence="2">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_186703</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.</text>
            <dbReference type="EC" id="4.6.1.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292174.1">
        <property type="nucleotide sequence ID" value="XM_018439272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MVA8"/>
    <dbReference type="FunCoup" id="A0A167MVA8">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167MVA8"/>
    <dbReference type="GeneID" id="29000178"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_186703"/>
    <dbReference type="InParanoid" id="A0A167MVA8"/>
    <dbReference type="OrthoDB" id="48041at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059049">
        <property type="entry name" value="TSEN34_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26577">
        <property type="entry name" value="TSEN34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TSEN34 N-terminal" evidence="7">
        <location>
            <begin position="44"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="6">
        <location>
            <begin position="107"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD74134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="196" mass="22411" checksum="534F27D35D286ECD" modified="2016-07-06" version="1">MVRILCTYFIDWAGKVTIIIPTELIYHQYAIQKQGSVVYCAHPDVERLRCDHRMVGALVGTLPRLPLQNTFHGLPLLLMPEEVTLALSKNIIVIESWEYPRTAKDRIKCSVYAYLWNLGFYITRGTKFGGDFLTYPGDPMRFHSHCIVEAVERDDEIKAIDLIGKGRLATNVKKTFVLASVTEKREEVFTLSWAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MYR6</accession>
    <name>A0A167MYR6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_67527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292594.1">
        <property type="nucleotide sequence ID" value="XM_018441809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MYR6"/>
    <dbReference type="STRING" id="763407.A0A167MYR6"/>
    <dbReference type="GeneID" id="29002715"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_67527"/>
    <dbReference type="InParanoid" id="A0A167MYR6"/>
    <dbReference type="OrthoDB" id="2389915at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="517" mass="58308" checksum="0046F5D7E9CB82E9" modified="2016-07-06" version="1">MKKYLKPLHFLVSSQSASVAIPSLIINTSGNNNTDLDDLTYNIKYENNIDKPALVDDNGSGISLLVFYFSNSAPIPSNDELMNLEFIKIIKKFNIFRDAHEKITTHFNRILERSVDLTYKASTPYYASELLKLFLSIKKKKYDICHKGYMLFNEANITACSNCSEPRYKEDSDDQGHANKLVPVMTMVQLLLDSQLCFALINKITKAEMQYYHLHRPSQYGTVSNVFDGQAYQRMKHLFSAENDIAISLSVDGFASHNIPGSVTIVHTTILNLLPMIHYERSHIIQIAMISELGAPANFWSYMKPTIDNLFVLQQAEMVIKILIKTIQAKVHVLMIMSNIPALAKLACHVGHMSKSGCRICNVVGETPGRGQYFQTFLATTICTKESFQNYNETSPSDRIKLNRQSSLAKLSFFSGPLFFALAEMHGLCHGIAKQVWELVCDKYGEKNSLVLCLATQREIGAAIAMTRSTVPTLFHGVWINVSTRSGYFRAVYWANFFLFIVPTRSCLQPSYPECTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N8A1</accession>
    <name>A0A167N8A1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit 6B homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_123826</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293349.1">
        <property type="nucleotide sequence ID" value="XM_018428953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N8A1"/>
    <dbReference type="FunCoup" id="A0A167N8A1">
        <property type="interactions" value="596"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167N8A1"/>
    <dbReference type="GeneID" id="28989859"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_123826"/>
    <dbReference type="InParanoid" id="A0A167N8A1"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000018">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000046">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="191"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="30"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD75309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="411" mass="46423" checksum="1C7D0F821B3BF1CE" modified="2016-07-06" version="1">MEEIGIHLKQEHKDSPAVVTKTSLLEELSEEDLYTKLKKLQRNVEFLELQEEYIKDEQNNLKRELIRSQEEVKRIKSVPLVIGQFLEPMDQHTGIVGSTTGSNYVVRILSTIDRELLKPSASVALHRHSNALVDVLPPEADSSIAMLGADERPDVTYQDVGGLDIQKQEIKEAVELPLTHFDLYRQIGIDPPRGVLLYGPPGTGKTMLVKAVAHHSSAGFIRVVGSEFVQKYLGEGPRMVRDVFRLARENSPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQTSNVKVIMATNRADTLDPALLRPGRLDRKIEFPTPDRRQKRLIFSTVTAKMNLSEEVDLEEFVSRPDKLSGAEIAAICQEAGMQAVRKNRYVILSKDLEKGYKANVKKEDTNFEFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NMM7</accession>
    <name>A0A167NMM7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_98602</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294330.1">
        <property type="nucleotide sequence ID" value="XM_018444057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NMM7"/>
    <dbReference type="STRING" id="763407.A0A167NMM7"/>
    <dbReference type="GeneID" id="29004962"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_98602"/>
    <dbReference type="InParanoid" id="A0A167NMM7"/>
    <dbReference type="OrthoDB" id="1721884at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000002">
        <property type="entry name" value="ATP-dependent Clp protease ATP-binding subunit ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050052">
        <property type="entry name" value="ATP-dep_Clp_protease_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003745">
        <property type="entry name" value="PRK05342.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF7">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="89"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="5">
        <location>
            <begin position="318"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="35"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="200"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD76290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="44045" checksum="1208A7C71963A697" modified="2016-07-06" version="1" fragment="single">IVKHLDEYVIGQARAKKILAVAVYNHYNRVRANLSLEPPHEDTHGVSADQEDRNQRRSWINPPSEAPHKPNTDKPLATPAIPEEKTVYEKSNVLLIGPTGSGKTLLAKTLAEILKVPFSMSDATPFTQAGYVGEDVELVIQRLLQSCDYNVKKAEMGIVFIDEIDKIARRSDVHSASRDVSGEGVQQSLLRMLEGTTIHITDKSSGGQGHGRRNTSSGSMYGQGPPGKGETYTVDTSNILFILSGAFIGLEKTVQDRMAKGSIGFGASLRTIGKDSSHALQPNQPEPLSLVEPEDLVKYGLIPEFVGRLPVVASVNSLNVDDLVKVLTEPKNSLVAQYKGLFELSQIGLRFSKTALKRVAEHALEKKTGARGLRRIMESILLEPMYDAPGSYIRQVVVDSKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NNG3</accession>
    <name>A0A167NNG3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_158287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294380.1">
        <property type="nucleotide sequence ID" value="XM_018433761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NNG3"/>
    <dbReference type="GeneID" id="28994667"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_158287"/>
    <dbReference type="InParanoid" id="A0A167NNG3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="70" mass="8167" checksum="15D0DD54717A46E5" modified="2016-07-06" version="1">MNITICSGARISDMNNVDEMQIRKFGCWKNAIMYGAYLTSLSRKEDIPSRFWFDASLPPYSSTLEVRHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NU23</accession>
    <name>A0A167NU23_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zn(2)-C6 fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_77303</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294639.1">
        <property type="nucleotide sequence ID" value="XM_018443244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NU23"/>
    <dbReference type="STRING" id="763407.A0A167NU23"/>
    <dbReference type="GeneID" id="29004150"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_77303"/>
    <dbReference type="InParanoid" id="A0A167NU23"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15486">
        <property type="entry name" value="ZIP_Sip4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF78">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="82"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="646"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="733"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="818"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="860"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="948"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="646"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="667"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="745"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="843"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="948"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD76599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="977" mass="109993" checksum="A465E3CC2FB36BEC" modified="2016-07-06" version="1">MRCSLDYYSDLCRRKKIKCDGTIPICSNCNAFHLKCSYKDTTKKRGPPKGYIEAIENRLYKLENILQDISKDDDPRSQILRAELSEPLKTAGGEQIRSRPVRRHQNSGEHGTPGHEKRTNKSRKNTQDSTRSNSPQTTPCSPQLSLIDSPVASHVGSPHSSQSVEDNTGQLSMGESGEVRYLGKSSGFYLLQNSRTYQNGAFHFTGRNQRSGSQSKSSLTNSSFDPLELPPKDLSENLVKLYFRHIYPVLPLFYKKRLVSSTCTVAEMLSPLLLNAIYAVASRMSPDVRVRSDPTSADTAGDVYFERARCLLDDYYDIPRISTIQALILLAAHQHGAMKPARAWLYSGMAFRMAQDLGLHRNCDHWDIPSEERERRKRVFWCCYILDRILSASYGRSATFEERDCDVPLPTVDDDDDEDEPETNPDSENAQPPVRIMIAFTHLISLCHILGDVLKNVYYAKSLYHASINHVEHILSSLNQRLDKWHDNLPFSIRYDPSNPHNSAIPEFLSPIVGQLHMVYYTTVILLHRPFIPGQKQAVNIISFPSNEICLSAANSILSIVNIMLEKDYLRYTLHYIIYCLFTAAIIFVQTASSPEEEKALEARVSITKILRSLDEIETTWTTASRTCGILAELVGLREINLGYDSSERTQDSRPESIPDNNDAFGNHNNISYEDTVDTTATAPSNQTSSYEDSRGWNNNSETRNTVKADAGLRNIYDSPHFGNHSYLPNYMSQSNIPEDKRGSLHPSSSWSEQSSLNNQDSQFVMTPLTDPFAAPNTVVSRPLNRQFNPFGSAFWGVPSSLDMNEWSTYLGNQGTQTYTQQQQQNNHHHQQDQNQSLQPEIQPRSQPQSQSRQLNYISNQPFDNVFPNPQYTDSTSLMPSRLLSPVHNFKSLGPLQMNPPQVPSTTARSAVPSYFPIPKNASFNPTNDLIHSDNSVDVLSGVNMPMNLPNSPSESSLLGLLSNPPDNKSVRNSCEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NU93</accession>
    <name>A0A167NU93_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UFSP1/2/DUB catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_165144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294658.1">
        <property type="nucleotide sequence ID" value="XM_018435169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NU93"/>
    <dbReference type="STRING" id="763407.A0A167NU93"/>
    <dbReference type="GeneID" id="28996075"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165144"/>
    <dbReference type="InParanoid" id="A0A167NU93"/>
    <dbReference type="OrthoDB" id="288987at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012462">
        <property type="entry name" value="UFSP1/2_DUB_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153:SF4">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MUG105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153">
        <property type="entry name" value="UFM1-SPECIFIC PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07910">
        <property type="entry name" value="Peptidase_C78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UFSP1/2/DUB catalytic" evidence="2">
        <location>
            <begin position="60"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD76618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="306" mass="35609" checksum="70C67842994D4816" modified="2016-07-06" version="1">MVSAESSQINDDLCTKSRNRIEQDLHVWDSIEELESGRRMVGVLNQLDHYFNLHKAPTTTVYMCSHQIDYIKSRLANVGWDCGYRNCQILMSFLQKNRILKRIGDIAQLQICLEKAWDQGKHQDYDTVGAKLFEKDVYKTTKWIGTTEVHTLFSYLGIRTTILDFSQPSGPNQQHGFLLDWIQSYFSTNEAPPLYLQYSGHSVTVIGIEITRKKRSLLLLDPQRHWFRAFSSNKTPSFFKRPFRMHPREISRNPQYQILVLGKVTDKRNQEANTSDTPGSLVWQPDYLLTDIERDTMKVVSTIRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NYP7</accession>
    <name>A0A167NYP7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_165390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294931.1">
        <property type="nucleotide sequence ID" value="XM_018435226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NYP7"/>
    <dbReference type="GeneID" id="28996132"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165390"/>
    <dbReference type="InParanoid" id="A0A167NYP7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="191" mass="21576" checksum="4FC7A685B6885859" modified="2016-07-06" version="1">MKEEMKAIKDKITLMGTRIDVVITGNITAINDIDALSALPASAHVPTSVASTSAALPTTESGDTNAVFGYIHGYMWNPKLKSRDQAEIQANVIKPKWAVDVRFDRSSNRELVKQLLYYLEKKFAGTDMRTRDLCKCIYTNFCSRRCQQRELPETRRALNTNSRRSGCETDNYTCCRLAYDAYKADIDLKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P534</accession>
    <name>A0A167P534_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation factor 1-gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_122276</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295304.1">
        <property type="nucleotide sequence ID" value="XM_018428864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P534"/>
    <dbReference type="FunCoup" id="A0A167P534">
        <property type="interactions" value="803"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167P534"/>
    <dbReference type="GeneID" id="28989770"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_122276"/>
    <dbReference type="InParanoid" id="A0A167P534"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000006">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1010:FF:000001">
        <property type="entry name" value="Elongation factor 1-gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1010">
        <property type="entry name" value="Translation elongation factor EF1B, gamma chain, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001662">
        <property type="entry name" value="EF1B_G_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036433">
        <property type="entry name" value="EF1B_G_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00647">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01183">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89942">
        <property type="entry name" value="eEF1-gamma domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50040">
        <property type="entry name" value="EF1G_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="3"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="87"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="EF-1-gamma C-terminal" evidence="5">
        <location>
            <begin position="259"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD77264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="46619" checksum="F7392EBD0E89587C" modified="2016-07-06" version="1" fragment="single">MASIGTISTYPNNARAAKAVIAGAYNGVKVDLKDFDFAKDVTPEFLAKFPMGKVPAFESSEVNLFESSAIGYYAALAKENSGLVGKTAVEKALVMQWILFAENEIAANVGGWVYPLLGYQTYIKPNVDAAQEKVKRAMAALDKILLTKTYLVGEEITYADIAVVCNLSLPYTLVFDKAFRSEYKNVTRYFTTVAGKDHFKAALGEVKLCETPLKFVPAKKEKKETAKKEDAPKKEKKEKKKEEVAEDPMDDTPKPAPKVKSALDLLPPSKFVMDEWKRMYSNNKTDVAMKWFWENHDSEGYSLWRADYKYNDELTLVFMSCNLIGGFFARLERARKYAFGSMIVCGENNNNNIAGYFLIRGQTIPEEVYDAADFESYNFTKIEPSQYEEKKDEIYKYMAWEVEGCQDGKIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PAD6</accession>
    <name>A0A167PAD6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(2)-C6 fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_179908</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295606.1">
        <property type="nucleotide sequence ID" value="XM_018438230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PAD6"/>
    <dbReference type="STRING" id="763407.A0A167PAD6"/>
    <dbReference type="GeneID" id="28999136"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179908"/>
    <dbReference type="InParanoid" id="A0A167PAD6"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="633"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="730"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="636"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="731"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="749"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD77566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="774" mass="86627" checksum="EC306A6FB15D7BDE" modified="2016-07-06" version="1">MDEDVTYEQNGTGKKRVRATQACVLCRKKKIKCDGTKPECLHCQAANMNCEYTESKKRGPRKGYVQVLEERLLQMESRLMSENGEGSRDPTLSPITSGQSSSDIYEKDTRQTKYKLSYADQTIQLPSLDIVLHLVDLFFKYINSVFPLIHRGTLRQAIMNGTVSKPLLWSVLAIGARFSEHPNVKTDPPYLAGEKFAVKAASLINSDLFEPTLENLQFWGIMACLEYGRASGSRSWIYGSLAMRFCQELGLHKEDTLNEPILASDGSVDAVAMALRRRVFWSCLCIDNAGTNNPQCFERMDCDAKAPNAAECMILRDPCFYASVDNKPVTNDSLMDIANHHMRMQQIFGDVNKYMNRAKSESASIVWPPIAEFSILDRKLRAWKENLPDRFQYTPNTLKFHKKNASVNYISLWLSSHAVWCSSMMVLHRGSLAHADMKPNEVPEEIYAGIQASISACKTSVDQATGIFRAMKDLCGYNILPYMGYSAYVFATVLMTSAFSKGPEAYKKSGDALQILYELIEASLFFTPIHIYGLKPYWLMCERLANMTKDLLAAHSRLYKTESRQSFPYGIKAEDVVPMNYRGSVQNQSMNSQSHTPGINISLAPSDISLSSLLTSNGPVTSTTQAYYNKNNGYFSTPDSSSSGGSITISQQHQNQNQNQQNQQNQQQTQSFPVLSEPYQNSNPSWGGEVDFNSLEFLYDSALFGQIMFDASKPSTIPVSGSYGYMPPINSEFSTSESSPQSSTPTTFGDTQGQNTRTSLQPYLNSERPLWNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PAV8</accession>
    <name>A0A167PAV8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_164489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295626.1">
        <property type="nucleotide sequence ID" value="XM_018435015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PAV8"/>
    <dbReference type="GeneID" id="28995921"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164489"/>
    <dbReference type="InParanoid" id="A0A167PAV8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD77586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="163" mass="19281" checksum="F192EF5B2CCB84B3" modified="2016-07-06" version="1">MRKPEETNISHIMTFGYSLDLTTYKNWIAVISFNLIIFFCSKYYKNKAVRRDVFVYILLRTGHNIVYESLLYPQVFVRYITGIDTLRVSIRFSWHKNIVSSQISEVMAFGKACLLQLARQSIEDHKSCNKELQYRLSISISLYYYLLLSIQRTIFYLKIFGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PQZ9</accession>
    <name>A0A167PQZ9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_69678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296416.1">
        <property type="nucleotide sequence ID" value="XM_018442143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PQZ9"/>
    <dbReference type="GeneID" id="29003049"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_69678"/>
    <dbReference type="InParanoid" id="A0A167PQZ9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="120" mass="13556" checksum="6B1D1C591F226398" modified="2016-07-06" version="1">MLRSHLALWVILSLKRKVTLLAVVSFGCLVIPTLRLPGIKQITCASIKLALIVWLTGPNYLKRTVSVVIALDRKKGLCSDICILRLKTTPKPSGMVYQLYYVHSTSARLLVLFKYQTRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PRS8</accession>
    <name>A0A167PRS8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_140502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296456.1">
        <property type="nucleotide sequence ID" value="XM_018430413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PRS8"/>
    <dbReference type="GeneID" id="28991319"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_140502"/>
    <dbReference type="InParanoid" id="A0A167PRS8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="212" mass="23962" checksum="33B60C38294DBC62" modified="2016-07-06" version="1">MSQREKDELEVYLNDICPNFTQMRKVLGESKAKSPAVCNTTTPLDLNKAQDMSKDEDGEDGENDGGDEASESSKSCKDQEEQGADVSNEISSQREAIVQSNSESSTSEHSDASAYSGKRRPKFFGKIVKNTAKRSVKSIEDIGHGIKEFNDARISLLESKYEEELKNQKEKLQKELQCEQRVKGVILMAKTFDWSEEKTKNELEEVYNQYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PW33</accession>
    <name>A0A167PW33_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_179625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296678.1">
        <property type="nucleotide sequence ID" value="XM_018438181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PW33"/>
    <dbReference type="GeneID" id="28999087"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179625"/>
    <dbReference type="InParanoid" id="A0A167PW33"/>
    <dbReference type="OrthoDB" id="2270197at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="275" mass="30714" checksum="F59B7BF2880C28C0" modified="2016-07-06" version="1">MTQHSTLSLSELAKALGSEGASASQVQGTSTKPLCENIFDVERGDLYDVLQRLRSAFWADSVQNTAITPTPLVKPTSQPTDLEKTSKEAKKALENIKVLSQTLASSPRKKQKTMLVTPQPHLQQQQQQPQSQAQAQAQAQAQAQPQPQPQPQPQPQPQPQLQLQLQLQLQQLAPAPAPQLQPRQQKPALKIKKPTAALPKYVTTKYSSLWPLKAHIMRQLKMSQMNYKEAKVLKALSEYEQTLGVVQRRQLAVYLLPVATGFRKPTVEKVLQKWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q4X3</accession>
    <name>A0A167Q4X3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_164155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD79074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297114.1">
        <property type="nucleotide sequence ID" value="XM_018434955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q4X3"/>
    <dbReference type="STRING" id="763407.A0A167Q4X3"/>
    <dbReference type="GeneID" id="28995861"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164155"/>
    <dbReference type="InParanoid" id="A0A167Q4X3"/>
    <dbReference type="OrthoDB" id="3263820at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD79074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="765" mass="87132" checksum="3E24DA93D871BD11" modified="2016-07-06" version="1">MNSITKIYTVMCTCSSCTKNAIGRILQNAQTFKCHNNADKLLDIGPKNRVNTEVIKEETDVEMVDVSETSIDYEDNYSIVSAETTVQSVPFLREDQIFQFEESDVETTSLASDNDDPDSSDESEDESKVEVAGVEDFEDMVASKILAFVVASLKIHEMSQTRQFMALFGVIFQAFYLVQAGRTAMLKFFCHLLVDFDKDTDLPLTIDVLKTMTDFNFMTKSIVKYTVCNKCFAIYLPGNRQPNCTFEKYTTTPPTYCGNPLFSDTKADRAVPLMVFPYNLLKNALAQHFAKPGFEHQIMWFCAESDAERAVLEKQHGTHFSELHCLHYFDPFRCTIVDPMHNLFLGTAKRMISVWKDLRYLPTAVLIRMQRLADSILVPPGYAILSTKIKSGFPYMKADEWQLWCLIYLLVLTSPSVTYSEIDSAHQLLGEFGKECETLYGESSITPNMHLHMHLRESMLNFGPVYAFWLYSFKRYNGKSKNIKTNHCNGLEVTFMRVFLEKAFIGSFLRAYSTNLLSPLIEFLEGVAQVKSNSDSSSPLNLDAGHPPALPFSLVMFQQAAINPWYNVTGSETLPPTTLPIKLQPLTMMKDDYYQWLFEFYVKAYQSTSVSFCVVGRIPIGEDVFVNNRIQKVKKISLLGQEYCSGEKKKRGSFVRVLFLERTNDDVSEFPGQIEYLFTHTIKIGGVKRVSTFAFIKWFPAYHLSSHQPLADQGLQLWDKGFMEEDASCIVPVHRLHSCFVLTTHKMQSGTQKHLVIPLPRKVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QAJ0</accession>
    <name>A0A167QAJ0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_162443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297409.1">
        <property type="nucleotide sequence ID" value="XM_018434626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QAJ0"/>
    <dbReference type="STRING" id="763407.A0A167QAJ0"/>
    <dbReference type="GeneID" id="28995532"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162443"/>
    <dbReference type="InParanoid" id="A0A167QAJ0"/>
    <dbReference type="OrthoDB" id="2425068at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="727" mass="83472" checksum="442C118E6F09302F" modified="2016-07-06" version="1">MAPTRKSNKTKECKCSVCKTRCGGSDTVSVQTFNFHKRRDDAGMNIFRNRVIIKRSVETTVSYVPEVINNDEQNSVAIDNNYDMDYDFDEMDTSIEVDMETQEPIRVLPLSESDAVFGYENEEFNSDLDSGGCKDNSSENDMLDSEDNFPEFNSELSFIYRFIVQVLALFVSLYVVNEGAIRLIAIMNKILKLFRDPFHLPVSIPGLKSMAGFNTFTDGIKKYVSCSECHSIYENNESTPHFCIFDKFGNNSMCVENGVRWSELHRLQYFDIVRCTIIDPMHNLFLGTAKRMIEKWVADGLIDNKKLVAMQKIVENMTLPPDYTMLRSKISKGFPFMKADEWKSWCLVYSPVALQGVLPKQKFENWMFFVNACRFLTKPNVSEDDVQSAHIALEKFGKGCERLYSKDLLSPNMHLHLHLRDTIKDFGPVYGYWLFSFERYNSVLKNINTNRRSGFEMTYMKTFIEDTRKGDFVHNFLKTSGPFNFSGIFDKLVTGYRPADSTTSTALYNWFSLPDFLDAAENPNLSIRGNEPLPPSALPLQKKAYEMMPRQEYDCLVGYYQAVYNNPTISSCKDVIQDTAFVNDWIEMLKSVNLLGQTFKGSRGTNGRGSYIQAMFIEGRNGAKYAYVGEIQYLFVHSFSPLVSTPHHRTPQSSQHTFAYVKWYKASRETSRKIAGVEIWDVAFSLPDFQSILPVHRILLPVAIVDHTTLRNISKKLIVPLPRKLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QME8</accession>
    <name>A0A167QME8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_179318</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297964.1">
        <property type="nucleotide sequence ID" value="XM_018438134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QME8"/>
    <dbReference type="GeneID" id="28999040"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179318"/>
    <dbReference type="InParanoid" id="A0A167QME8"/>
    <dbReference type="OrthoDB" id="2103031at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD79924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="189" mass="21896" checksum="7B1356054FBD471C" modified="2016-07-06" version="1">MTENKGSARDYVESYVKESQPDVDGYLSEQQPQYDPTKAPTQASSSSSKPNTSPAPTPSQQFKLHLPTVNPIQTNETPKDEQKLKDQNNPKIEWAVRDFMDQKREIHETALENCADLHEELFTCFKDGSWWDKAKMCEDQKQRFWTCYHQQKKFLKAVNYKGAGTTPEENDINLYKAMRLRPEDAEKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QNU7</accession>
    <name>A0A167QNU7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">OPT family small oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_121598</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298019.1">
        <property type="nucleotide sequence ID" value="XM_018428815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QNU7"/>
    <dbReference type="GeneID" id="28989721"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_121598"/>
    <dbReference type="InParanoid" id="A0A167QNU7"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
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        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="551"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="619"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="652"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="699"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD79979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="752" mass="84168" checksum="26C7686B90BA7D2F" modified="2016-07-06" version="1">METTLSKREVSSKAASFEEGERYLDEKEEKGSFVDSHKGTRDPKDIDYENEDLDLEIVNQIASVEDDPNTKVLTVRAFVSGSLLACLGSSVYQLMQFKPVPVPLSNMFLLILAYLLCQGSTRVFKTGTLLNPGPFNVKEHTLIYVIVSSANASAYGTYILGAQQLYYTEYPSAAGGIFLLFATQIIGYGIAGQLRPFLVYPSQMIWPTSLPTVSFLKTFNGPGNESRFLIKFFFAVFFAVFVWELVPQYMFPLLGGFSIVCLAKRDSVWVQRIFGGISVNEGLGIGSISLDWTSLSYYAPLVLPLYVQFNIYGGILILWLLAPLVYYFDVWHAKSFPFLSNGLYQLNEETGEAVRYPQALVLDELNNINLTALEEVGRPYYGAIYAIQYIFINFGVTSMVTHVILYHGADIKNIAFAIFRRKESKEQDIHNRLMSAYKEVPAWWYYIIFVCGIGLNIGIGYANKSQLPWWGFLIAIILSTVLSLPLNMITAITGTGFGLNVVAEMICGFMLPGNPVANMYFKTIGYNTMSQAGAMAADLKIGHYLKVPPRIVFSAQMLGTVIGCIFNYIVNYTIINSKREQLLDPNGNIWSGSTPQTINSAAITWGAIGPMFMFGPGTLYYFFLWAFIVGLFLPVPFWLLHRFFPKVGFNYINVPMILVGLCTLPGSSSSWITLSWVIILVSQLYVKRRYSKWYVKHNYLMSAALDSGASLMSFLLAMTVFGGGDGIERPFPNWAGNNNDIPYYDYCCADCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QQV0</accession>
    <name>A0A167QQV0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_59137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298134.1">
        <property type="nucleotide sequence ID" value="XM_018440442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QQV0"/>
    <dbReference type="GeneID" id="29001348"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_59137"/>
    <dbReference type="InParanoid" id="A0A167QQV0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="235"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD80094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="330" mass="37551" checksum="D52CB976D8F6926A" modified="2016-07-06" version="1">MNNTDNSSISLLHVMYNEILFLKAGQEKTKLEMKAQIKELKLEMKTSIKDLNLEITALQSQLDNRNISNQHTSSSVSVISSANTIHKLVSVFCEITLKHIFKMISEDLGIEVTSNEKATLNMCTKLICDDMAAYPLVIALGPNPSWGSIPVALKKEMCARHANIMKDSGIDITRCLGNWASTARVAHLWRDRHKRLQSLIFITMSHLPGVLFFWKDLERPIDMILLQSDQSKSFAQKRKVLLTLNNFSGHIVDYTPTNVELLFLSPNTTSHLQPLDGGIIRAFKAYFKRKKYGKTYQYIGMIQNGDQDKIRPIDKIFEIVHVVNEYLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R7N3</accession>
    <name>A0A167R7N3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">T-complex 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_62088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299079.1">
        <property type="nucleotide sequence ID" value="XM_018440897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R7N3"/>
    <dbReference type="STRING" id="763407.A0A167R7N3"/>
    <dbReference type="GeneID" id="29001803"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_62088"/>
    <dbReference type="InParanoid" id="A0A167R7N3"/>
    <dbReference type="OrthoDB" id="276323at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF11">
        <property type="entry name" value="LD23868P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD81039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="837" mass="95326" checksum="B3E8099ACDC47A20" modified="2016-07-06" version="1">MTPENSGFYTVDADKLHTSRKPFHLQRRFPQQQSLTTLETAELKREAFLQERREKLHQKFQQVQSVVRQVKARREHRKISILKSLETAELNRRTQMEERRMASKNLVERAKVIASQNIRRHQAEQERLRARLESRLKASEARRLCLQDLRTSKMASRRKQPLKEESFGPTSKTKGVSKQSPKISVKTCPETGHTKKQVGWSSLLKAYQSLGLPALTSQVDFNELGRILHQSRVVTVTSKMLSIALSLADKDSRRRARILLTAYMMLMCPREILQDRNGSEEQILLTSAKDVLVQFEIWMAAHGPHAGQVERRVFAESWTRYRSLFEAWKKRDQKKLVEDMITYYLELSNVKRSLEEHDVEGVGAQLEKQLEQVKAKIVQVGGPASLERLNNLESKKGTQEEVKQDKEEDKAPVYKPDLSTIFGPFSNIPNERLAHELIVSPDFKLQHKEITPLEQHVKTIATKAFFDKLENELDNGDTSSLPGLLADVRERLLGLSPLDGDLRETILEIMDIELIQQQAANNTLDVSKYIQTIIDAIAQLCAPVRDEAIAAIREGSQPIVQIQQLLELLDFMALDLANFKLAAIRPHLVEIGVEYEQDFFAKTISNNPEMPITNIWLCKAFHRLHDISSQRNPENVQPHLNRPSHKAVIEDAFVALVTASDTINSETVPETLLWDADRLTGYQNDIQALVIVACLLMLAKNFGSPADPPQLATTLFELLKDHTTTIDNLSLEIQRGLDEKRKPLVRSMVDKTLSHTDTIYLLLTRRVATIIRSYLNSPQTLTPAAAASQGLEHVFQPLTEVCANLYRLATHHRKVYGSWYDTIISEEEATISSTRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N642</accession>
    <name>A0A162N642_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">KxDL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_175440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KXD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441005">
        <property type="protein sequence ID" value="OAD66144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284184.1">
        <property type="nucleotide sequence ID" value="XM_018437485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N642"/>
    <dbReference type="STRING" id="763407.A0A162N642"/>
    <dbReference type="GeneID" id="28998391"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175440"/>
    <dbReference type="InParanoid" id="A0A162N642"/>
    <dbReference type="OrthoDB" id="10258877at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039843">
        <property type="entry name" value="KXD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019371">
        <property type="entry name" value="KxDL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13511">
        <property type="entry name" value="KXDL MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13511:SF0">
        <property type="entry name" value="KXDL MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10241">
        <property type="entry name" value="KxDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KxDL" evidence="2">
        <location>
            <begin position="12"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD66144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="111" mass="12822" checksum="B1D039D21A4ECC3E" modified="2016-07-06" version="1">MSNNINPIADHLLQMTNETDNQRMLKEQEEALAIYKSTQQSLCAFNDFSKARYQDVNKHFESHAKLLKEIKGDLESVFGRLQNMKQHLGNKYPAETLVVLQKYPAPILQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NGB6</accession>
    <name>A0A162NGB6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Box C/D snoRNA protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Zinc finger HIT domain-containing protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHYBLDRAFT_172596</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with FBL, SNU13, NOP58, NUFIP1, RUVBL1, RUVBL2 and TAF9. Interacts (via HIT-type zinc finger) with the RUVBL1/RUVBL2 complex in the presence of ADP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the BCD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287384.1">
        <property type="nucleotide sequence ID" value="XM_018436832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NGB6"/>
    <dbReference type="FunCoup" id="A0A162NGB6">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NGB6"/>
    <dbReference type="GeneID" id="28997738"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172596"/>
    <dbReference type="InParanoid" id="A0A162NGB6"/>
    <dbReference type="OrthoDB" id="272357at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.190:FF:000001">
        <property type="entry name" value="box C/D snoRNA protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF3">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="15">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="90"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="407"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAD69344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="450" mass="51425" checksum="E5D5C6163493DFE5" modified="2016-07-06" version="1">MSATRALPKITRVHEKRKMVNQFRSLASWSRATLTLFGKRIEASYQGSQSDCLNSWVEEHSVGLSNGITECQSHYLMTTLSMDSVQDESQTTLTSNEPTIEATNESSEIPTDHQPSTIENNTHDMTFTLGADGQVDIEMNVKKPPTTAAPGPCEQCHDQTWKYKCPRCDMRTCSLACVKQHKAEKECSGERSKTHFVPMKQYTERDMMSDYVYLEDTSRKSDTLTRERLRAFPENNGGKHIDSRIKHLVRQARQLGINFDVLPTGMSRAKSNTSNYSSNKKQIYWSIECIFCHKDRRERILDHSIPSGMPLRSFFENMLFSERPIGKTPYSLFRHQVQDFVDAGMGRYVIGLKKEGLPKKSFVNITSYLDKPINESLRGERIIEFPTLYIWLEGNVEPEIELLDKEEYTPKIADKPKGNRNGEKPAEEVAIQMPMEASTEEPPKSKTQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NIB3</accession>
    <name>A0A162NIB3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="5">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PHYBLDRAFT_126793</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="5"/>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287984.1">
        <property type="nucleotide sequence ID" value="XM_018429125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NIB3"/>
    <dbReference type="FunCoup" id="A0A162NIB3">
        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NIB3"/>
    <dbReference type="GeneID" id="28990031"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_126793"/>
    <dbReference type="InParanoid" id="A0A162NIB3"/>
    <dbReference type="OrthoDB" id="448573at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000022">
        <property type="entry name" value="CDP-diacylglycerol--serine O-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF61">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OAD69944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="228" mass="24978" checksum="D4787B2750C8EEAD" modified="2016-07-06" version="1">MSLRNRSKDILKDDDPTRIATDNGHFSLARNFYIADVITLLNGVCGVTSIFATMRYLISNDVNDLYISMIAMPCGMLFDFLDGRVARLRNRASLLGQELDSLADLISFGVAPASLAFAIGMRTYLDSVVLTYFVCCGISRLARYNATVAMMPKDATGKVNYFEGTPIPTSLSIVAILAYLVYSGQYLEDLPGQLVNLAGKSWGFHPIVLLYAVSGTLMISKTLHIPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NLA2</accession>
    <name>A0A162NLA2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_71969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293308.1">
        <property type="nucleotide sequence ID" value="XM_018442573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NLA2"/>
    <dbReference type="STRING" id="763407.A0A162NLA2"/>
    <dbReference type="GeneID" id="29003479"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71969"/>
    <dbReference type="InParanoid" id="A0A162NLA2"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="523" mass="58216" checksum="473562012FD96B7C" modified="2016-07-06" version="1">MFCLFLSQFFTPKQPSPQNPKANGNTYPKAPTLLLYDKIDTTVIAWGYDAQRKALLPGCKGILVDRFKLCLDPEIRDSIILLNGLTSVKVISDYLRLFHKYILSELNSTLGAVYDPTRFKYSLTVPAAWDDSAKAIMRRAAIQAGIISQSNHPSRLVLTGEPEAASLFCDKQSKQFKLGSGDRFMICDAGGGTVGLIVFEHSQDRSTMTLKEITKGSGKSCGSTFLDLNMRNILMSRLGHHANENKAAIDNLIKYFVTTAKPEFEDGEDAYFPLPQLMNISASELAAMDVVDGSLHIAMEELREKVFDPVVEQVFELISGQLRKALNISTIFLVGGFGQSKYLLKRIKEKFVSKVVSIAAPNRGEMAVTRGAVLYGLNSADCTTHVRYMHRRDIPERKVTKVDGSVRAINCFQVYIRKGDIVIADECISQDFYIFYPNQSNSVLTLADLYVYDGDGIPPRYTDSPGVHKAAHFPIITKCLPCAKNGDIIPVKTIMYFGQTEIFVQTIVGNQTIIYTWPFDTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PHN7</accession>
    <name>A0A162PHN7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Enkurin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_169187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290967.1">
        <property type="nucleotide sequence ID" value="XM_018436017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PHN7"/>
    <dbReference type="GeneID" id="28996923"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169187"/>
    <dbReference type="InParanoid" id="A0A162PHN7"/>
    <dbReference type="OrthoDB" id="2258642at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="450"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="650"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD72927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="719" mass="81254" checksum="E12C394FEC6DCEF1" modified="2016-07-06" version="1">MSLKSKESRASTGQKFWQLKKFSLGHQAETFSQDPKISAEATNEVDSLESTKPKNKRLSSLLSHHRRQASPKQPTKVDTSLTPLLSPRKTSVISLPAVMLAQDVGHQQNNSSLPGLPKDQKHQRASTVRKTDGQRSIRRIVSLASHRSVITPEVFEPDPRPTQRKSLDSASEEDSDEQQLPKEPPARKMSPDLRRSLRPSEKDKDKDKDKDKDKDRDRDEIPKYTLRDAPVRLNNSEVANTDDAPSSVVRRSSKASDDCGYKERLQQRARTLRPAASLATLRQLAQPMGEELPTRPATSFRRSFSQDEEAAASWRLQHPHSHSPPHSPRTSGARPLVRSDTAQSMRTLTRRVNAREDLQGWSSANNLHSRANTATTTIPDHNDIDAPLDSSMNSEASWWSGQPSDEDEHRPDTDTSSDSSEHSPCPRRRIDTVDQLRAALDQDKAVIKALQACNRDIAFLSQNIDLLSTEAADWKKKWESEKLQKEQCKEELTSAVRRLAEASDKARQLSSANEELKRDLEKCRQLETKEEPMEPCSDDNNTRIDQLKAQLELSQDQVRVLKATMEQFLRMGIFSSDLAQGSSCLYDSTSDASFIKAVVRELRYAQLRQRQTEPNTSVESVQKSMLTTNEPLVLSDTPAPKDEETENSTAAELDVRLRELLLEKELLQAEYSKIPVSGGNALTRRRREELEDRLDSVDSQMSKIKLWMRHRNVLYSTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PKX5</accession>
    <name>A0A162PKX5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_168229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291837.1">
        <property type="nucleotide sequence ID" value="XM_018435822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PKX5"/>
    <dbReference type="STRING" id="763407.A0A162PKX5"/>
    <dbReference type="GeneID" id="28996728"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168229"/>
    <dbReference type="InParanoid" id="A0A162PKX5"/>
    <dbReference type="OrthoDB" id="5573160at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004330">
        <property type="entry name" value="FAR1_DNA_bnd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718">
        <property type="entry name" value="OS01G0519700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03101">
        <property type="entry name" value="FAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAR1" evidence="2">
        <location>
            <begin position="30"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD73797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="534" mass="60252" checksum="78FE2696EA50BF0C" modified="2016-07-06" version="1">MDPLYQRLLKKGFADSVSAIEYCRDVCAEYGFTIKQEASANKNIYVYCSREGLPDSQRNPKPSPQRKRPSKRCDCKWRIVLSENEQEQWEFRKSLTATALEHNHEMMSPDEMVKAWPPEVSDMIIRLAQQRLQTHEIREAVKQNFPDITWNERRFYNRLTEERKRIRQRGVVDRSQRLLLLSARLCSVVAGNEGWAICVENDLVRMFDNFCQLTRLTPEAIESLVDMQQNQIQSDMSGERSLQPHRLVGNSTGDSLSIADPSASIGMSSNSDLEDHCSGTPAAKRRKSNFRSNESPKGTQVVTVPSYTLFVRSQPLRSPSDSSSQGSRRTMADSPTGLESHSPQNGPPTAFNGPSAASFFALTSPTSSSSSTSNMAFSRHRIDMPQQRTSFSPYSMSATSFSSPPDMPFNFDGASIMAPPPSSSNIFGSMHSTPQPHQTAKVHHNLVPDRHEHTHPHEHRTPVFGYYAVKNDVESAVLQEQQRAIMRQQEHEYDQRVQRGYPQGFTTLPMIRANNEDQQASPIVVATPASQQWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PQI6</accession>
    <name>A0A162PQI6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcriptional regulator of RNA polII, SAGA, subunit-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_78912</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293107.1">
        <property type="nucleotide sequence ID" value="XM_018443400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PQI6"/>
    <dbReference type="FunCoup" id="A0A162PQI6">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162PQI6"/>
    <dbReference type="GeneID" id="29004305"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_78912"/>
    <dbReference type="InParanoid" id="A0A162PQI6"/>
    <dbReference type="OrthoDB" id="10264870at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="HFD_HFI1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Hfi1/Tada1"/>
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        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
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        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
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    <dbReference type="Pfam" id="PF12767">
        <property type="entry name" value="SAGA-Tad1"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    <sequence length="474" mass="50827" checksum="62BE9EF9B7A2CD3B" modified="2016-07-06" version="1">MTVTMAAPILITPSGKPNSHDSNNSTHHVPQSHFSQTISNGRQDVIALKQLLADALGENGPLYWDALRDFVIGKLNRQEFDFYASLYLSRHNAHLHNAFILSTIHNAQTAVPPPSRDRAVGWAKRKRGKEGGLDQDVDQDPRKQKLKMDVMALSKTERDRLKSLVKSGKDKLNPFVDTLLGPRVSQGPPPPLPLDRLPPSFNADYARGLLAPLCADLKELPSAQTLHSRMTSTALEHGLLGGVTEDAVHAMLFATESYIKSIIFSTITKRRINRPIGVCMPSSSTSTIASSLPTTATNTANTALSSSHSLPSSASASSLSSSLPTSTSTTLTAPTTIPSSSSSSSSLQSKPQPDTNSIFTSANTTNTTNGAISTSTPTSTSTPTPTPTPTPTSTSTSTSTSQNESDTTPTKHSLGLGDLAFSFELAPYILVETPMNAERLIALRETQDDSSEEEDDYDDDDENEDDSSEGEFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PSH2</accession>
    <name>A0A162PSH2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_65471</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
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        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
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        <property type="entry name" value="ABCC_MRP_domain1"/>
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        <property type="entry name" value="ABCC_MRP_domain2"/>
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        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
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        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
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        <property type="entry name" value="ABC1_TM_dom"/>
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        <property type="entry name" value="ABC1_TM_sf"/>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
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        <property type="entry name" value="ABC_transporter_C-like"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="PANTHER" id="PTHR24223:SF353">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE VMR1-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
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        <property type="entry name" value="ABC_tran"/>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
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    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="68"/>
            <end position="87"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    </feature>
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            <end position="858"/>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD72486.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
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    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1529" mass="171585" checksum="330F8910ABCA9AA6" modified="2016-07-06" version="1">MHMNSGLEKRGEDTKRALASPPEPPRCFQYQEVQLQPEDGIGHEGLLYKDQKRNLSVPFSDNSRIPRITFGTLGLVIVTGQSLYGVLSNFPQSPSDEDVGNVISTIAVFSSWLYAFVLCLFSQNHQFPNNWGWTLNVHLFILYLVTFSLSVYSLVISIWNFPGQSFYQGVPLLLCALISTDLVYVTGMAEYGPPFIDETNREVTSSQVCSIASSLIFNWSYSVIRTAYKKNSLSEKDLPVLEASDRGRNLMTIFGLHPEKKLVHRIAVANSGSLLVQGLAAFVSAFLFYIPAYFVNRILLLVQDISDGEVDDTTMGKTFSSVFYLALSIVILGIITSQLWYWVRIKGMLDIEIYKKTLSRMDSASTVEKDGTEDKAVGTGGNPKEEPGSTALTGSIINLMSSDSARIAKVSNIWFTLFTIPLEFGTGILFAYQLMGASCFLGLMVLVIALPINHYNAKMYNRAQRNLMLVRDKRIAMLNEVFQGIRQIKFQAWETNWEKRIMKTKNFEIGYLKLIYLSNVLFNFVWKGSPLLVTLVSFWSFTSLQGNPLTAATAFTSIAVFNELRYALNALPELFIQLGQISVSIKRIEEYLNEEEITQPPLNSIVPRVYQKDLSRPTHCLKALFSRILISSSRKNALTLISGATGAGKSLMLLGLLGEATLTKGKVNSPISSILRNIQNESSGQSFSPENWILESSVAYAAQTPWLQNASIHDNILFGLPFSEKRYNDTVKACALVKDLLYLEDGDMTEIGEKGITLSGGQKARVALARAVYSRAKSVYMDDVLSAVDAHTAKHLYENCLIGPLMKNRTRILVTHHINLCLNGSAYLVHIDNGRADVFESPEELRRSGDLYNIIKSEEQEKNIQDDEEQTVEEIVSPDSSVASPSNENDTSKTINNPPRVLVEQETRAVGHVKIRHYIKYLKMVGSSWFWIVYASIVLGCRALEVYAVWWVKLWSQAYAKEKHPEPTLMMVSPSNTLIPEFELLPEKPSDDNVDMYLSTYMILTAVTVICITIRYGFLYLGTMQASKSLYAELLHCVFRTPLRFFDTTPVGRILNRSSKDFETLDSELPIDLANFTIQATFVISTLLVVSLALPWFSIPMLITSAVTCFIGSRYMPATRELRRMVSVERSPLFTHFTETIVGVTTIRAFGATRQFMSEMLIRVDNCLRPTFHRVAASRWLSVRFYITGAVINLFTAITILLSMKYIDASTAGFCLAMVLEYADQMYILVLRYTSVELSMNSVERIIEFIEIDQEAPAITDIRPPIEWPSKGEIQVDNLEIRYAPELEAVIKDISFSIKPKEKIGLSTLAQSFFRFVEASKGRIVIDGIDIKSIGTEDLRNPTLFFGTIRSNLDLFKQFDDQAILTALKRVHLLPPEEDLEENAFSETASNNVNVFWNLSTPVSEGGKNFSQGQRQLLCLARALLKRTKIVFMDEATASVDFNTDKAIQKAISTNFADCTIVCIAHRLHTVIEYDRILVLDQGNVIEFASPLDLISNPNSMFYKMCHDSGEFDGLVSLVKTKAQLVGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PSW6</accession>
    <name>A0A162PSW6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_64574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293707.1">
        <property type="nucleotide sequence ID" value="XM_018441315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PSW6"/>
    <dbReference type="GeneID" id="29002221"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64574"/>
    <dbReference type="InParanoid" id="A0A162PSW6"/>
    <dbReference type="OrthoDB" id="168171at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33324">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33324:SF2">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="230" mass="26334" checksum="A76CE8DAD2EF6C14" modified="2016-07-06" version="1">MSSQNNNTNRRDSKLWNKDGVNGGLSSIIILVLWLSEEANYRRWKGSNAGQGIKDSLEENEMPEEEVASTMRETMIRKFQYFYDLEPVMSDRPSVIPPFPISSNEEADVKSAFSLDTFDTFDDEEVLMNGRQEISKSSSFAQRRLFSAISHAASNRPGKKVCKTIDAGIVDIVRMAEEMQREKVQQFWQNLAAEEVFQKTQLVLDERRVAVEEMRALTERIRADSESAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PTI1</accession>
    <name>A0A162PTI1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pre-mRNA-processing protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_98149</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SNW family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293887.1">
        <property type="nucleotide sequence ID" value="XM_018444045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PTI1"/>
    <dbReference type="FunCoup" id="A0A162PTI1">
        <property type="interactions" value="851"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162PTI1"/>
    <dbReference type="GeneID" id="29004950"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_98149"/>
    <dbReference type="InParanoid" id="A0A162PTI1"/>
    <dbReference type="OrthoDB" id="666364at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017862">
        <property type="entry name" value="SKI-int_prot_SKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SKI-interacting protein SKIP SNW" evidence="5">
        <location>
            <begin position="147"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="282"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="487"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="346"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="488"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="506"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD75847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="547" mass="60492" checksum="CBFD5C2EF9F6702C" modified="2016-07-06" version="1" fragment="single">PPYGQRKSFRPRYPEDYGNGGAFPEIHIAQYPLDMGRNKGGRATETSGGALTLQVDADGNVKYDAIARQGHNDNRIVHTSLKDVVPIIERKDVDVEKLTMDRPSEEEVQSVAEKTRAALEKIVNGKIAAAQPKNVVKTSGGTNKDPTYIRYTPAQSQSSDTFNSGAKQRIIRMVDAPTDPMAPPSFLHKKVPRGPPSPPAPVMHSPPKKLTAKEQAEWVIPPCISNWKNTKGYTIPLDKRLAADGRGLQELTINDNFAKFSEALYAADRHAREEVRQRNLMQQKLAQKQKETEEEKLRNLAQKAREERSGLKPASSAGASADLPVPSNRPTAASLMPDYDSSDESGSDRSDDESSHDSDSNRQRDQLRRERQKQRERELRMNKMGTEAKAKHIAREQGRDISEKIALGLAKPTLSKESMYDARLFNQSEGINSGFKDDESYSLYDKPLFAQQASSIYKFKGKGNSDVLGSTDADDIEQSIKQDKFGIGRKGFQGAEGGEGSSGPVEFEKETIGGRQKAKDADKDVFGLDTFLNKAKKGKRAREDDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PYF0</accession>
    <name>A0A162PYF0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycogen synthase kinase GKS2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GSK2</name>
        <name evidence="11" type="ORF">PHYBLDRAFT_64325</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293446.1">
        <property type="nucleotide sequence ID" value="XM_018441282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PYF0"/>
    <dbReference type="FunCoup" id="A0A162PYF0">
        <property type="interactions" value="487"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162PYF0"/>
    <dbReference type="GeneID" id="29002188"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64325"/>
    <dbReference type="InParanoid" id="A0A162PYF0"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000082">
        <property type="entry name" value="Shaggy-related protein kinase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="52"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD75406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="393" mass="44591" checksum="1BCB7373E41D50A4" modified="2016-07-06" version="1">MSQSKTPATSDLSLLTGSVTNSKKSDTLQESPQITRVPAKEGKTGKGIELEYRHQKVVGSGSFGVVCQVRFVKNGQKYAIKKVLQDKRYKNRELEMMKKMDHPNVCGLEAYFYSTGSRGDVYLNLVLDYVPETVHRVARYHAKIQQPIPMLQVKLYTYQLFRSLVYIHSIGICHRDIKPQNLLVDPVSGVLKLCDFGSAKCLVVGEPNVAYICSRYYRAPELVFGATDYTSQVDVWSAACVMGELLLGQPVFVGESAIDQLVEIIKVLGTPSREDIKAMNPRYIDHKFPQIQPYSLQKLFRWRTPPEAVDLMSRTLVYNPTIRHTAIKLLVHPFFDELRHPDTRLGNGKSLPPLFDFSSQELSVDSELFNMLVPEHAKEMLVKRGLDLMSFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q8Y5</accession>
    <name>A0A162Q8Y5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type zinc finger transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_62154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299136.1">
        <property type="nucleotide sequence ID" value="XM_018440912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q8Y5"/>
    <dbReference type="STRING" id="763407.A0A162Q8Y5"/>
    <dbReference type="GeneID" id="29001818"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_62154"/>
    <dbReference type="InParanoid" id="A0A162Q8Y5"/>
    <dbReference type="OrthoDB" id="10034966at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD81096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="816" mass="93095" checksum="97A0801FA8383DDA" modified="2016-07-06" version="1">MVPRIAKKPKHARVTFFASKVHGQTTFKCNLRRHLQKLHVSEDFTNNGPIENLNNVHDCEINQSSVPENGDSLCEDKDTDSIIGNMTDTKLDNDSSKINKSVSETDKSDNGSNIDMEENSMMSSITNLDSPVDEDVDQLNSLLESCSTWNSNTSTTHSFPDLQAMVLLALLSRLNALLNYQSRKKYKLPVLTSTSVMIDLPKNKSVLAYVNMPSDHLKLLATNPMKAKSIFAIPDCMSDQFICLQQDFWSGDVVEFAGGPANAHFLVESFHMIGISAVIRVKKLLWVDASPINIDFCFSMSSGKIDPILPVHRSLLLVPHFLKWCITQGPDNPNNENHFYKVRIAPITLFTDDTSGSRSKQYDPYKSWSMKCAALFFKERSSIENIYFLSAIPKKDDASGMSLLPVFVKALTMLENRLVMFLAEDNKHVLVVAPLFWIEADTPYHSKICGLHVPTCLYSCHKCYIMLQRTTEKLKNKIHYMGSHASRTKEYYQIAASTPDRSSIIPDAPSTGKNFKASELSFRYRATDILLHLDSFDLSTNTPIEILHNILLGVAKYLVTDLVNGVLKGHPGLLNKLMNSLKEYRKSQGLSQKFARLLGHCSLFLGRDFKILIQILPIVLATKFNCGIKSHKSYTLKPKVYLLTHLLDNFWRFETALYYETKKRLNISRDICLKFAKLAVMRHIIDDVSKYFYTSLFSNILFFYCFVPEIPHLSPCNNIFGVFALKESRDQPVHYIIEKVSSLRVEHYRVESSVHSQENNFFLTQRFSNNLTTLLNQLTMICKLDIHIHYDSNLVINLNKLGSYWFFASQVYNRWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T7X4</accession>
    <name>A0A162T7X4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_70195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441000">
        <property type="protein sequence ID" value="OAD66812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284852.1">
        <property type="nucleotide sequence ID" value="XM_018442232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T7X4"/>
    <dbReference type="GeneID" id="29003138"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70195"/>
    <dbReference type="InParanoid" id="A0A162T7X4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="106" mass="12233" checksum="322542AE41B9FE25" modified="2016-07-06" version="1">MRDFIGLGYSELTKDFRTCEGQQPSTLHRIRPIPTKISVKTVIIPTHCKITVILSSSIVFFSEVIVESILYCFQEFLIFSICCCFFTASVPIVVNSRYYYNFWAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T8Y1</accession>
    <name>A0A162T8Y1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_151890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD66952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284992.1">
        <property type="nucleotide sequence ID" value="XM_018432775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T8Y1"/>
    <dbReference type="GeneID" id="28993681"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151890"/>
    <dbReference type="InParanoid" id="A0A162T8Y1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="280" mass="32040" checksum="21510FC7AA4EA13C" modified="2016-07-06" version="1">MDKNKKLLSSLTPQLIIKTYQQQKFICTANISMYLIEWLVFENRFSLNNSQCALCLVLTKVLFKRTLHLYMDHYKFRSYMDNSQKSNSPVSSIAKLHEFDMANVVNLKYSPLSTKPKTHNMTHLTEDIRRFGSALNFETEKDKQFNKIAEFIKPNNNKDKTFCNLFLGGSQVLADNNDTGNITTLKDNSFAAFVIKNSIGTTPSIGLISGSMVTFLQPTACTSEEMKNNYLKLEMTDDCMPLDSLKPLCKIALMKVNDTIYMVNLSKFSSYWFYLQHGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TB79</accession>
    <name>A0A162TB79_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_175850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441008">
        <property type="protein sequence ID" value="OAD65673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283713.1">
        <property type="nucleotide sequence ID" value="XM_018437593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TB79"/>
    <dbReference type="GeneID" id="28998499"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175850"/>
    <dbReference type="InParanoid" id="A0A162TB79"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="113" mass="13299" checksum="4C5D232BB9EF8A47" modified="2016-07-06" version="1">MSHLPGVLFFWKDPERPIDMILLQSDQSKSFGKEEHLCYWEIRLTGIAEDIILSFSLTLRFSSNQYSFTTWPKRQLDHVLITKVDKKQIDYLKLNLLIDKSLQENQVTILGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TCK1</accession>
    <name>A0A162TCK1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_189016</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285572.1">
        <property type="nucleotide sequence ID" value="XM_018439599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TCK1"/>
    <dbReference type="STRING" id="763407.A0A162TCK1"/>
    <dbReference type="GeneID" id="29000505"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_189016"/>
    <dbReference type="InParanoid" id="A0A162TCK1"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF692">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="48"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD67532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="439" mass="47978" checksum="2787917A4BD8A040" modified="2016-07-06" version="1">MQLRHLKHEKDSSSSIDRESVHDLPLAISEHEVSFSHGVEREAQGSSYLAYFNVVCVVAGTGALGLPYALRQGGWIGILIIALSWLFSTYSGVILIRCLYYNGHTRLSSYQEVAEAAFGKIGGWIAFFFTAITLIGVPVLYLLLAGQNLHTVLIGTSAELTFPIWVIICAAAVAVPFVFFKSMKEVGFLSAFGMLATVIVVLIVVVTAARDRPNVVNVHHDPVIWDQFPIALSSIAFSFGGNPVYAHVEAGMRQPKQWGRVVAAGLTTCVGLYFLTAIPGYFVYGDQALSPIYNNLPQGPEKTASAIIITAHVLLACPILITSFALDLEKLCGISSFHHSRVVESLLRFALRSCMIVVITVIAIYVPFFGDFMSLLGAFSNCALILIFPVMFYFKLTGLRNKSWYELILGFFTVLLGIVGLIFGTISAVKALKDDFSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TGE1</accession>
    <name>A0A162TGE1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAM50A/XAP5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_136409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286412.1">
        <property type="nucleotide sequence ID" value="XM_018429784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TGE1"/>
    <dbReference type="FunCoup" id="A0A162TGE1">
        <property type="interactions" value="369"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TGE1"/>
    <dbReference type="GeneID" id="28990690"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_136409"/>
    <dbReference type="InParanoid" id="A0A162TGE1"/>
    <dbReference type="OrthoDB" id="1562195at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048337">
        <property type="entry name" value="FAM50A/XAP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007005">
        <property type="entry name" value="XAP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722:SF0">
        <property type="entry name" value="PROTEIN FAM50A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722">
        <property type="entry name" value="XAP-5 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04921">
        <property type="entry name" value="XAP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM50A/XAP5 C-terminal" evidence="2">
        <location>
            <begin position="177"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD68372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="314" mass="37379" checksum="2E3F0715BA6C6674" modified="2016-07-06" version="1">MLEKARRKIYEESERERQKISKLNEVRVGSDKFITTTGDIETQLKSSTIGLTELRDYRKIKENLEEQQLREAAKTAPLGEEKRKKRKKKQMMRLSFEDEEEEEKEEEAKELEASPEAGEDDDQEETEKIQKKRKMLKDPTVDTSFLPDREREEEERQMREELRKEWLRRQEELKSEVISITYSYWDGSGHRKSVQCKKGDSISQFLDACRQQFPQLRGVNVDNLIYVKEDLIIPHHYTFYDFIINKARGKSGPLFNFDVHDDVRLVNDATLEKDESHAGKVVERSWYERNKHIFPASRWEVFDASKNYGKYKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TJ63</accession>
    <name>A0A162TJ63_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_188549</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD69012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287052.1">
        <property type="nucleotide sequence ID" value="XM_018439527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TJ63"/>
    <dbReference type="FunCoup" id="A0A162TJ63">
        <property type="interactions" value="218"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TJ63"/>
    <dbReference type="GeneID" id="29000433"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_188549"/>
    <dbReference type="InParanoid" id="A0A162TJ63"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11372">
        <property type="entry name" value="RNase_PH_RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="6">
        <location>
            <begin position="12"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="136"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD69012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="230" mass="25219" checksum="3E404A2134E56497" modified="2016-07-06" version="1">MVRPDRRTENTQLRAFAASQNVLNRADGSAKFDFGNTSVLVSVVGPVEVQLRDEKLDEATVEVVVRPAVGYPSTKEKLMESMLQSAFEPVIMGGIMPRTLLQIVVQIVKDDGAVLAAAVNAVTLGLLDAGIPMKYMASALTCMIHKDSHDLVLDPTADELENALSVHTFAFENLHNTPHVLLSDSTGRFSEEEYFTSHDVCFEAVDKVQGFLRTAVISKKEKEQQQTIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TKN1</accession>
    <name>A0A162TKN1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_117989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285923.1">
        <property type="nucleotide sequence ID" value="XM_018428611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TKN1"/>
    <dbReference type="FunCoup" id="A0A162TKN1">
        <property type="interactions" value="198"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TKN1"/>
    <dbReference type="GeneID" id="28989517"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_117989"/>
    <dbReference type="InParanoid" id="A0A162TKN1"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="111"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD67883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="535" mass="61391" checksum="35DA6DF70940D3F7" modified="2016-07-06" version="1">MLGTGVIAGVAGTALYETDDRFRHVIFAIQRSGISTSIGVRVAADYKWTLSKKYSSKEEEIKAKKECDQRCAERVLIGLQKLGGIYVKLGQHISAMAYILPFEWTSTLSALQDRCDPSSPEDIEALFLSDYGHSIDEIFEEFDWKPIGVASLAQVHKARLRPDVNGVRLGNDGWVAVKLQHPRLDEFCKVDLGTVSFIMGYIKKAFPDFGFDWILQEMKESLPQELNFVHEASNAQQVAQNFAQERAQNQTSLVIPDIVWAQRRIMFMEFIEGARIDDLAYMKEHDIDPSTVSTELTEIFSKMMFLHGFLHCDPHPGNVLIRPAKDPKSKYNFDLVLLDHGLYRILTEELRTDYAHLWTSLIRGDEDGIRKYSLRVGCRPEAHRLFASLLTGREWETIESADLSSNRTDIEVQRVSGRAKNFLLKVADILARLPRVVLLLLKTSDLLRCLDETLRDSVTKHMTYIIMGRYCAEAVWLDAKKSLFDSIATYGISWNVLKQLFTAWWEYRSLEFGLWAYQARMSNWERLVRWKLVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TLB1</accession>
    <name>A0A162TLB1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Copper fist DNA-binding transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_182738</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287502.1">
        <property type="nucleotide sequence ID" value="XM_018438666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TLB1"/>
    <dbReference type="STRING" id="763407.A0A162TLB1"/>
    <dbReference type="GeneID" id="28999572"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_182738"/>
    <dbReference type="InParanoid" id="A0A162TLB1"/>
    <dbReference type="OrthoDB" id="5600085at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="72"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="196"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD69462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="302" mass="33740" checksum="5A2A801980516EB0" modified="2016-07-06" version="1">MYITDEEGVVKKFACLTCIKGHRSSGCLHADRELIEIKKKGRPVSQCAECRELRKTKQMHIKCICTTRKSQSIQPPLSSYPSLSGQNQTRDFYMSSSSSDGTVTPPCDRHASPIPLDNPDQFTFRKDAASAGLPQSRRHFAIPIHDPLDDLDSDTPIYKPEDHQLTTVNCTDVLGELSHTSSEDLMNKIYSRFTHHNHDHDHNHNHDHDHDHSHSYNHGNVNGNGNGHNHKIHHLKPCSCGDDCRCATCKPHPGSTALNRPAAVMDQDGVMLCGCGCQKSLSNCSDCFQDMCEEYLLSHPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TQN9</accession>
    <name>A0A162TQN9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_171686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288342.1">
        <property type="nucleotide sequence ID" value="XM_018436645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TQN9"/>
    <dbReference type="GeneID" id="28997551"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171686"/>
    <dbReference type="InParanoid" id="A0A162TQN9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="153" mass="18259" checksum="53AFDF0A391BBEE8" modified="2016-07-06" version="1">MYFLPFGFLIFFRFRILRNRLVLIVPVPVLALLLVHYILQNTSPQTNRIKGVKSKTNGDINDNIHINGLRIYLLAFYYYYYWNMSNEEPWSVLRVEQVDKEPGLNLYTHIVMNSSIFIFSVLRFYTCIDIENGYMELRFLSLTVSIDRSYICY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TRN5</accession>
    <name>A0A162TRN5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_171272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288562.1">
        <property type="nucleotide sequence ID" value="XM_018436551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TRN5"/>
    <dbReference type="STRING" id="763407.A0A162TRN5"/>
    <dbReference type="GeneID" id="28997457"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171272"/>
    <dbReference type="InParanoid" id="A0A162TRN5"/>
    <dbReference type="OrthoDB" id="2284923at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="285" mass="32702" checksum="1DE259096DA50D12" modified="2016-07-06" version="1">MSNLNSVGACRSGFSLLLSSRLYKTFVRPIFEYGLAITILRKKDYTEIERIQDKCLRMIVGGHATSSTAVLKHICNLPSMQFCSDILISNFCICAQSLLSGCLLSLLHLHHPQSSSLPALSKNSLFVSIPITLNFHSNTKLKRFFETFHQFKFDQMRLTNTKVLLQACHLLWWLKLKKFLRGRIEDLRLGMKIRENLCRFCLLRKIWYQSLVSPNEVLTSKKDLHILKCYYIRRLACIRIKKLSAMYPSTNNKRGEQIQMAMGANSVSNGCKFNFYGSQSDVNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TUV6</accession>
    <name>A0A162TUV6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_147680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289212.1">
        <property type="nucleotide sequence ID" value="XM_018431931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TUV6"/>
    <dbReference type="GeneID" id="28992837"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_147680"/>
    <dbReference type="InParanoid" id="A0A162TUV6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="254" mass="28722" checksum="A02C6C932FAD7EC3" modified="2016-07-06" version="1">MFSDDGNGNIIDYRDQQAPTFVDGTPFRSKIWTDLQKCIKNDVQLEWTTMNAAVMGKDASATIQDTVDNLTTNFISLQIKKSRVAEVMSEEWNLIIKDISRHPLGTNKEESLQARVNWIDYWLEESLTAIDTILVIGIDLSTREIVGATKRKALQNRLSAPKVIDPIIMKRDYTPVYLPLITCLTLIQSEKSWAIVKGNIKRNKSSGIESFAMHIIEASKAVPVENLRGSIQHFTQKAHGCLQENLHNYMCPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TV01</accession>
    <name>A0A162TV01_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhomboid-type serine protease</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_134785</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289242.1">
        <property type="nucleotide sequence ID" value="XM_018429673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TV01"/>
    <dbReference type="STRING" id="763407.A0A162TV01"/>
    <dbReference type="GeneID" id="28990579"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_134785"/>
    <dbReference type="InParanoid" id="A0A162TV01"/>
    <dbReference type="OrthoDB" id="2146116at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="402"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="12">
        <location>
            <begin position="304"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD71202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="505" mass="55350" checksum="9F05E3C48A109EF0" modified="2016-07-06" version="1">MFGRDNPNNQDNPNRSQASPALAAQAVNPNNSPHVQFAANSPTVMPSQYPSPSPSVNHHGFQTPFSASESSSPSQNRIGSPVPESRPSEKTPQDSQTALLLDNGNGIDGGNELHKRSVGQPDSIAMNNMPRADGFSRLDSNQSPQPHQYQQHQHQQQYPYQYSQYQYPPPPPQGNGPYIHPQQLARPLPHGYNRSVWLRLLIGPVRKPWFSWLSALAMLGALIYEFVRNYQLTSSVIETSPFNPMIGPSSTVLINVGARFTPCMRALPAYTASTVFGGCYQSTDATCTLEELCGFGGFESGIPDQSFRFVLPIFLHAGIVHFLMNMLTHLRLGIDIEREIGLPRYVLLYMGSGIWGFVLSAMLSQGKSASMGCSGALFGLIGYTLVDIIINWKTNPDICRELSTLFVSIIVSLVLGLLPGLDNFAHIGGFAVGIMMGILLVSIRRKASTTTKGVRWVLRGIAAALLVVMFVVTIRQFYASADPSQICPNCKYLSCLPVRDWCDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TV81</accession>
    <name>A0A162TV81_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_148655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288133.1">
        <property type="nucleotide sequence ID" value="XM_018432129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TV81"/>
    <dbReference type="STRING" id="763407.A0A162TV81"/>
    <dbReference type="GeneID" id="28993035"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148655"/>
    <dbReference type="InParanoid" id="A0A162TV81"/>
    <dbReference type="OrthoDB" id="2389915at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="56301" checksum="F2EA789467CDD556" modified="2016-07-06" version="1">MATGDTPAVSDLMNLMHHNAQYGCCHCFAHGESIAKTMCFLESKGPAPMRDVGSICRAEGSRPGGGRYNAFAELPTLTCSAFFGQDEMHLLDHGTGHQLYQALGGKFCPGTAGLGRKSHGMHLQERLQRLEYPFALDVSLDDIKKAVSTSRADILTAFASTWRSMKESNGKRKAIDWMDFLLFIVPTVVIDHLYFADAKQTVRDLVLACSIVQQWSITASNIVAVEQAIGRWHSFLRCKISDGKLKSNIFVMNQHMLVHLGFMLREMGPLRAYSCHLIERMISAYTSVIKSRKEPGKNMENVLFRMVAISHCHGNRPARTGPADKRTSNFEVASDDVAGPQLWSSPTRYSMAELANTIGMEWEDLVQQLLPFWAGEGVSSFEEQDSVVCTTKMWKDLVVYRVRSSFDSRHVRANNLVVLKHIYGFVRKFFSHTVKGVTRLFAATESLSNVRPLLGMLFLVSSNHSQGEIRIVDVKSFKGMAGLVHNTKDGAIRHIVWPSLTHNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TWH4</accession>
    <name>A0A162TWH4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PHYBLDRAFT_95920</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288413.1">
        <property type="nucleotide sequence ID" value="XM_018443928.1"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TWH4"/>
    <dbReference type="GeneID" id="29004833"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_95920"/>
    <dbReference type="InParanoid" id="A0A162TWH4"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14879">
        <property type="entry name" value="MYSc_Myo17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036037">
        <property type="entry name" value="MYSc_Myo17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF13">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 15" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 15" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10 15" id="KW-0518">Myosin</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="905"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="943"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1209"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1604"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1631"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1659"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="18">
        <location>
            <begin position="1"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="19">
        <location>
            <begin position="1912"/>
            <end position="1966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="574"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="15">
        <location>
            <begin position="642"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="767"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="791"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1735"/>
            <end position="1781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="767"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="792"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1735"/>
            <end position="1754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="1756"/>
            <end position="1777"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="91"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OAD70373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1966" mass="219669" checksum="BD4CE9E5751698B7" modified="2016-07-06" version="1" fragment="single">PSEDSIVNLLQTRSRRNLPYTRAGHTNLIVINPYQPLELLNDATLQSYADAGYRDVSEHKLFMQPHVYDLAARLYFHMRRTGEDQSVILSGITGSGKSTTRSHLLDQLLLLSTHSKKENKLQQQIKNSLVILEQFGHCRTVQNISATKFGMFQEIQFSERGRILGAKTLTYAFDKTRVTTVPKEERSYHVFYSLIAGTTVDEKNALHINFNPDYFNYLGQSKCIAVPDMNDEIAFGNLKSALKICGFKAKTVTQIFQLLAAILHLGNLQFIDTQEAGTAQEACNVRNRDILDTVSVMLGVSPTKLETSLTYKLRMIRNELCTVFLNPQGACEQRDGLARAIYQLLFVWIVETINTKICYNDSEPANFVGILDQFGFQNFKTNAFEEFAINFANERVHQFLIRQRFNDSEGLNGAMVRDGVPLPKVITMDNSACLELLVGREHENQDKNASKSAALGLGGIVGALDRDCAKYQSGATDATDANFLAGIQRTQANHSSFSKTSYAFAFGINHFSGTVQYSVEFFLEKNLDSLSPDFVNLLRDNSSNAFLSSLFQGVGMATESHPKDDRTIVKAQLSSKPTRAPSMKRPNKRRQNTENAFANVPIPESGELDTEDLRKQKIIKEAEEAYENMQVTTVMDQLYMTLRDLFLTMADTRVYNIIHIRPNDTQSPDLFDAKRVKMQVRAFLLSDLTLRCSQEYANYYTFSEFLARYDRLVASLQIDSSKTERGQVEVVSAIMNWTEFQAYVGQEMLWLSFDTWKELEDGLRAAEKEERARAKGGDGLAKSGMMMDMGDDGMGGGIGGGPGGPGGGAYYHDSEDRLLPPGVYGDPSHMGPGGHGGMVRSSAYGDNASYMESEYGMKPEMEGSQWGDESEWGMKGLAEGKMVEDFHVPQNEQVEEMPITAVRIWWVRFVWFCTWWIPSPLLRILGKMKREDVQMAWREKVTLCMCIGFFSCVVIFFIVGLGEVICPGTKKMYSFANVAAHTETNDIFMSVRGSAYDVTNFAITGHGTTAISASQDAMSELAGMDVSYSIPPPLTVACEGLVTSSTIKVTPNATIVLSTFVHNSGDQLTIPTLTSMASSTWYWNTFLPEMSLYKKGPIVVPIKELLADFQSWGRTAAAINGRVYDITDYIATAKTYDSGSTASDYHYLHSTIEEIFTKFSGTDATDKWNQYKGSMTPEQQAMNMNCLNNFFYIGDVDERETPRCQFTNYLLLSFAILMCVVIGVKFLAALQFGGAPTPEDHDKFVICQVPCYTEDEDSLKKTIDSLTVLNYDDKRKLLFIIADGMVMGSGNDRPTPRIVLDVLGYDTKNDPEPLMFKSIGEGSKQLNYGKVYSGLYECEGHVVPYIVIAKVGKASERAKPGNRGKRDSQMICMNFLNKVHFDGEMTPLELEIFHQLKNVIGVNPSFYEYVLMVDSDTEVLPDALNHMISCMLHDGRIIGLCGETKLTNEDDSWTTMIQVYEYYISHHLAKAFESLFGSVTCLPGCFCMYRIRTPVKNEPLIISPKIILEYSDTHVDTLHKKNLLHLGEDRYLTTLMMKHFPQYKMKFTPHAQCKTVAPDRWKILLSQRRRWINSTIHNLFEVVLLPDLCGFCCLSMRFIVLIDLIGTLTLPVSVCYMVYLIYVIASGSGPLPVLALAMLAASYGIQVVLFVLKRQWQHIGWMVFYIIAIPVFSFFLPVYSFWHFDDFSWGNTRVVVGDNNQKKIIVADDEKFDDKMIPVKKWSVYEQELWEMGSQGSRETGVTGNSYRSHQTRGSKIGGGSQYGGGSQYGGGGGGSQAGDYDYYRDSTPGIKGSRAQTPMGYPGSVISPGSEYGGGGQNYGGNPPMNRGSRTMSVNSFGNPEFFAGGNPGMIPGVDQGSAMYDQRSVGGNRIMSQQPPPQGEYEMPAMSAHMSQYSIPMSQGGLQPMTPPGFPSDDEILSEIKNILATANLMSITKKQVREQLSAFFGFDMTPKKEFINTSIEYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TWK8</accession>
    <name>A0A162TWK8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CCHC-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_171769</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288433.1">
        <property type="nucleotide sequence ID" value="XM_018436661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TWK8"/>
    <dbReference type="GeneID" id="28997567"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171769"/>
    <dbReference type="InParanoid" id="A0A162TWK8"/>
    <dbReference type="OrthoDB" id="2279695at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD70393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="449" mass="49902" checksum="096BD27863E8DB70" modified="2016-07-06" version="1">MALPATQQETTPQGSPHYGDNNFPPLSPNIHPSTQPNAPTHALPTTTPITFASLVDPEKQRSLTRIERVLGSDDPYAIPTECRFGTSPHSVFYDLPQSDDSFMAAFWTAIHAAFSEEEAFAEVTSVRNNTHIVELYLESDTLCNRACAEPIVVQDSVILAHRAISSSVMMMKLNITGLPRLSRPCLNELIRSSLYSFGIIKEVVIYLENRFFTGSGYVYLERPPNQDRVYSPLVHKIPCEGYGHVFGTWAKMGPHCRYCKAMGHVLADCPTRPIESRTCHACQAVGHLQATCPRINNPHPNNNTSNKRIRKQPRRESQSTPARTQTLPPVLPALPKRKKKSAPRTPPANQFDILGKSAAEIEAELAQLSTHDPYRRVLRAALKNITDESNRDIPYQEYDPNKDDLAMDTQDSENGAESESSSDSDNADNDQHGSLMTGIVVHQNINPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TYP6</accession>
    <name>A0A162TYP6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_170967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288923.1">
        <property type="nucleotide sequence ID" value="XM_018436456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TYP6"/>
    <dbReference type="STRING" id="763407.A0A162TYP6"/>
    <dbReference type="GeneID" id="28997362"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170967"/>
    <dbReference type="InParanoid" id="A0A162TYP6"/>
    <dbReference type="OrthoDB" id="2206543at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="164" mass="18673" checksum="726D17E711D38BED" modified="2016-07-06" version="1">MKIYEFCTNFVILSLNILNYKIISLAKIHIRFCSNNLTEYPQFSLLVHNDFKDKITQLFADIGVSVKTDFDPLDHRIIADPAHAHKPVQERQQLAYKLHRQRLLALCLRLPAPLGKSVMRHFCTVESSSLRLPPVCLEQYLEDRNLPSGPQVSAIDTATAMVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U1M1</accession>
    <name>A0A162U1M1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cardiolipin synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_177621</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290792.1">
        <property type="nucleotide sequence ID" value="XM_018437909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U1M1"/>
    <dbReference type="STRING" id="763407.A0A162U1M1"/>
    <dbReference type="GeneID" id="28998815"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_177621"/>
    <dbReference type="InParanoid" id="A0A162U1M1"/>
    <dbReference type="OrthoDB" id="10020554at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043337">
        <property type="term" value="F:cardiolipin synthase (CMP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000017">
        <property type="entry name" value="Phosphatidyl synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF60">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE (CMP-FORMING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD72752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="25559" checksum="6971E91439B4C01B" modified="2016-07-06" version="1">MLFVRLQVRPLISCAAKNSSETLCGIKEIIPTHENIYTIPNLLTFGRLLSAPYIGHLIIQHDYNLALGIFALAGFTDMLDGWIARRYNLKTVVGSIIDPAADKALMTVMTITLAMEGVLPVPLATLILGRDAGLILASFYYRYISLPQPKTLVRYFDFSIPSAEVRPTMISKINTALQLLLVGTSLTSITMGLPSSEIMTAMHWVVGGTTIWSGASYIYTKDAVRILNKHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U2V5</accession>
    <name>A0A162U2V5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_169291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD73032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291072.1">
        <property type="nucleotide sequence ID" value="XM_018436036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U2V5"/>
    <dbReference type="GeneID" id="28996942"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169291"/>
    <dbReference type="InParanoid" id="A0A162U2V5"/>
    <dbReference type="OrthoDB" id="2279226at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="273" mass="31782" checksum="B72168644C743012" modified="2016-07-06" version="1">MSQPLMSHAIAYTHQPPTVQEVARRYVQWRDEDVGLLLTDLEQPGHYEKWKENKSSYSKRVADEVFSKLMYHEAIKFKVRWLESRFRRLDDQLRAITNEQTRADTKSKLLKEFRYYDRCKNIFSVDSTDTGDADDSSSKPETDAEKTTQLTTSFTLPFGVPSETVETIPTSDPMMVNTPVPNSQATTRQSTPYGIIHPETSRTQLNTSHAVPSKRKKSQRSVENMEEERRLKYVELELESKRMEHDERMQGMKLEQLRLEIELQKLKSGTSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U3F2</accession>
    <name>A0A162U3F2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_145549</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291182.1">
        <property type="nucleotide sequence ID" value="XM_018431472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U3F2"/>
    <dbReference type="FunCoup" id="A0A162U3F2">
        <property type="interactions" value="477"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162U3F2"/>
    <dbReference type="GeneID" id="28992378"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145549"/>
    <dbReference type="InParanoid" id="A0A162U3F2"/>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="4">
        <location>
            <begin position="49"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD73142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="464" mass="52257" checksum="C35EDCC7F706C53E" modified="2016-07-06" version="1">MSLFAKNNTETINTFDTENLQDKSSDAPKIFNTEVPFDHIISRKVKSSRHIILNQPEILNAIGFLEVQYLKHFIKAAENSPSVNTVIVKGTGRAFSSGGDVLSLYKSIYIPNNIHGYKKAWDIWNIIASMKKPYVAIMDGFSIGTGAGLAAHGSFRVATEKTVFSMPEAAFGFVSDAGSSFFLNQLDNMIGTYIALTAQYLKGADVFFSGIATHYVPSHRLGAMEYRISQLDVVDHDEVDSIIEEFSADPGTQYRHTLKGNVVKTIKNCFKYNTVEEILEALDKDGSDFALKTKTEMLKLSPTSLKANLELIRRASKSSFASCMESESRAAMNKLLCPDFKEGVDARFVKHTQPRWNPSTLNAVDIDYVRSEILDKQNVYTAKIFHENAFHAYPYWKYGLPSDKDVQKIIQNPETAFYNYYQVVSYFLQKSNYKFGVLEKVIDILDRNTRSGDKSLAGKIEWIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U6U5</accession>
    <name>A0A162U6U5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_65243</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290873.1">
        <property type="nucleotide sequence ID" value="XM_018441421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U6U5"/>
    <dbReference type="STRING" id="763407.A0A162U6U5"/>
    <dbReference type="GeneID" id="29002327"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65243"/>
    <dbReference type="InParanoid" id="A0A162U6U5"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20336">
        <property type="entry name" value="Rcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="160"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="164"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="92"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="293"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD72833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="60092" checksum="70A999940EB759CC" modified="2016-07-06" version="1">METLSSQQQQQQRQKYSWPVRWLSRPLKWMFPDLTTDQLRNLLSKFNIANLLFCYCIPFFYVFYPTLLMPAIFLRSLSFVVGWAHGLVSRHHPNPQRHGTSTNNNNNNNNNGAGAGVGNSRRQPRRPDTISRTNTNTSITSNTNTNTNTNNDGMNNMYFWLQRCSICLDHTYALCLENCRDQFCKECFARYVEEIVNTSWGLGVTRIRCPVCKETIAQSEWSRYVSSDIVERYDRYNQPYRAFSRHCLDCETVITPCHGPRSERISHERRLELISHDLSLLHQKSGHHNQNRLQEKDKEDREENDKQKQVIELQSMFEKARLSRRTSRVGQVQELYGQMVPLLKKQAGECDKYKLCSAISKQLVALETLPEAWKLLQFVHVANFPIETCTTCQKQVCLQCGEFSHPDLSCLEHLKHRLTIDNESDESLIVKWKLEHTQPCPNCSVMIHRDEGCNKVDCLLCGFRFCWSCGSKWSQQCGFYQCQQQPIKDDIGITPEKKVELGVPDMDAIDAKRPTNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UAB9</accession>
    <name>A0A162UAB9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_145091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291653.1">
        <property type="nucleotide sequence ID" value="XM_018431364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UAB9"/>
    <dbReference type="GeneID" id="28992270"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145091"/>
    <dbReference type="InParanoid" id="A0A162UAB9"/>
    <dbReference type="OrthoDB" id="2285798at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="430" mass="49946" checksum="6E3339E59EA8B0BD" modified="2016-07-06" version="1">MSTHQYSLDGVQSTDSAFNYNSASLNHPSTDRHLFSYSPHRKYSKNNSPASVSQRSNRSPVPDRISEHLSCNDSLETSRSSSMRRRSTSVLSERKSPLIVDRSFRSEPRDRRIESSRTETEGQPSRHSTLLEDAPLDIRQAIEHSLETIREMRLSRPHPRSLVEDNQKMSLTSRPRRDSALSMTDRELARTTTMENYTGPSAEEDIFHYSPSKRQQTVSSGSWQNLSENALQQSLLQTIEERCTSMETAMNERVRLLEQRYRTIRPISETKHSRPVTKGVQVELQPVLTSREIEERDERDMKADMLDTLMAELDINDLRTFQQSVHAWRARSRLLTEVRCFVDGVEKVIWNTPYVPLSSICHIGHEDNRQVGLVEDEMMCESHRVRYERALLDAERDKANALERPPYTRERLDATFDRLTRWSHSVRHPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UCT1</accession>
    <name>A0A162UCT1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_143538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293322.1">
        <property type="nucleotide sequence ID" value="XM_018431005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UCT1"/>
    <dbReference type="GeneID" id="28991911"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143538"/>
    <dbReference type="InParanoid" id="A0A162UCT1"/>
    <dbReference type="OrthoDB" id="3247418at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="607" mass="68988" checksum="2C4034C82D81B1E1" modified="2016-07-06" version="1">MSNDNDMKIGFGDDVDIEYQVEAKDLPLLAIDSLFNSESKDDDVIGAVILDISDSESEDVREHSSPSDMPADPTHAFNALFAVLFISKYAVDSTGAVPLKFFNEILEYPNKDLHVKLHNQTIVYTFCRPRFEDVINYWRNRSHVPDMKFEIHDSAYLSMGSVVSVVRYIFASTTCPHQNGTIKENAVFVGLIPGPKEWCGDSYYLVSIFCYFLCYSNSCCLEKLYGLVYFNLVECTVIDSTYSLYIGTAKRIMEKWVSSGLITDTHLAATRVDAENVLLSEYYTSLGTRIGRGFPFMKANEWNISMAHLNEVHNSLEVFCRECEVLYQTPFRSPKMHLHLRLQESILSFGLVYRSWLFGLERCNGFSKDYMTNRRDGLETMYMKKCLEDTYQEDFIQQTLLVIQSGHSAIILELTTSTAAAILSHINAVLGSHEIKFVIIKGNEPILPSTLPLVLKGEIFMKVSEYEHLSSIITRYMMIKRLFTVVRLVAPIILSTVGYTNLNQSIFSAKYTGAKQEISQIQYLFVNLFVDHLSLNEFACLRWYKEIVLQPRAGEGVEVNEVGFKDDSMNSILQVHRICYPVAVGEHLGLEGKAQMCVVPLLGKIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UET3</accession>
    <name>A0A162UET3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_111803</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292643.1">
        <property type="nucleotide sequence ID" value="XM_018428239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UET3"/>
    <dbReference type="FunCoup" id="A0A162UET3">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UET3"/>
    <dbReference type="GeneID" id="28989145"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_111803"/>
    <dbReference type="InParanoid" id="A0A162UET3"/>
    <dbReference type="OrthoDB" id="1594986at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010481">
        <property type="entry name" value="Cdc24/Scd1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053026">
        <property type="entry name" value="CDC42_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06395">
        <property type="entry name" value="CDC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="167"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="3">
        <location>
            <begin position="611"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD74603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="694" mass="78784" checksum="210B182762321D0E" modified="2016-07-06" version="1">MPSCLIESPQKPIQGQSLYHTCLSVLDRLALVNGFQQFLDSPVQKTQLLNTDPVTKLWNLCQLGTPLYTLFNALDPKEPLTLEYNHNLNQANNAKAIVYHFLVSCRKELDFAEEDLFGITDIFLDDTNGFVKVVNTITKILQILQDRGVISAKSPNRNSDPNAPKDTRDKIVLELLETERKYVQDMELLQASTKEHKIYIPYNILTKFFYVFIQSYMRELQIQKILSPDTVHYLFANLNALVDFQRRFLIQLEDIAEKPAQDQQLGLLFVQTEDAFIVYEPYCSNYYAAQDLVKEKAAELQKLDHVLSPTHQLLSMLIKPIQRICKYPLLMSSLLKSTNPSWQSYPQLIQGSEAIRRVAEKVNETQRKQENLQLVQDLKKRMDDWKGPPIDSHGALLLQEKLMVTVNDLDREHLILLFEKAILICKELKEGSKNRLTKTNTIMKKKRRASIQAKGTISVNRITHILNKSTASGGKYYSSSNSNSVQQFTLKFRNEEQLKQWEAVIDKTRMNIQSTSSSTPLLPTPSQSTSDKTSFIDSLDDDDDDESTKKFIRPIASSSSRLSELANIPLSLLLSSTSTSTSTSTSSASSGSSYFPPSLLSPVTLTGSQDTLKVKLTYNEGVYCIVTPHQIKFSDLMERVEKKIKIVANLKPNAVLRLKYRDEDGDHITISSDDDVQMAFESRGQNTVNLFVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UG31</accession>
    <name>A0A162UG31_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_142957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294012.1">
        <property type="nucleotide sequence ID" value="XM_018430906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UG31"/>
    <dbReference type="GeneID" id="28991812"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_142957"/>
    <dbReference type="InParanoid" id="A0A162UG31"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="294" mass="33021" checksum="FF7B0E6634C7AD81" modified="2016-07-06" version="1">MLHEKLEEYNSAFEKIMEELEEPEMPEDPKSFVPSTTDKTPKKNQSVAALPTPIASRPSNAQEVQGDQQTLVAASEHLVALQNKMDSSSKIVLEGPTKESIRRIENTVSDILTSMEIIKKTIADRTLPAGSMPANNVHSSSNGQFAHRMRSSDVSFKGTDPKKIAENNSRPGWDLTSNFHSSYNYVLAKSLLTYLQGQGNILTSDVLMSKMADIVMNHFSNQQKESRKSEEEGNKKRQKSRRYQRTAVNATYGRHKAAINRKFGNVNCSFAFQKDVFSERHSDNEDSLTMFQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UGU9</accession>
    <name>A0A162UGU9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protoporphyrinogen oxidase</fullName>
            <ecNumber evidence="4 11">1.3.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_181065</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:25576"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="EC" id="1.3.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.4" evidence="4 11"/>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293153.1">
        <property type="nucleotide sequence ID" value="XM_018438411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UGU9"/>
    <dbReference type="FunCoup" id="A0A162UGU9">
        <property type="interactions" value="249"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UGU9"/>
    <dbReference type="GeneID" id="28999317"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_181065"/>
    <dbReference type="InParanoid" id="A0A162UGU9"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="12">
        <location>
            <begin position="12"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD75113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="538" mass="59819" checksum="23E8030D9BBB66FD" modified="2016-07-06" version="1">MASSIAVLGGGISGLSAAYYLARFAPRTTKIVLIESSRNLGGWLKSNRVPPGLHSSAPVADEKGVLFESGPHIMNPRGTSGAVLLEMVKDVCLTKEMLTINSSDYIEKGRSIYYKDQVNVLPTHLTSLWKDKSPVTKSVFRAILRECFVVKNAGLLDETIYDFVCRRFNQHVALNIVGPYVQGMVLGDIKALSVRSVLPLLYDLEQEYRSVTIGYYRTGGRRREGFRERGLAARARRDDPVWFGQADEWSGISFKQGVQTLPDRLSAYLSQCENVEVRLDESVERIDPVTTSRSTMHFEHVLSALPSATLHELTSSCPLPHLTSTPCVDVAVAGLAYPSTASNYTGNSIVLPHPDSDYKSPVPGTLSVDCNSNNFLHQDHEPHFKITTAFGGHQWKNIFGTTRIQQLDPQLVFKHAQEVARVLFGIKDRPTHGMVSLNPKCLPQYTLGHEERMGELHNALQTAYSHRMSVTGQSYFGTSVPESVENSRMLVESLVVSGALGSREMMVNGLWQIEENQRDEWKDSNRLSKSHIDILLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162URX7</accession>
    <name>A0A162URX7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_164375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295503.1">
        <property type="nucleotide sequence ID" value="XM_018434995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162URX7"/>
    <dbReference type="GeneID" id="28995901"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164375"/>
    <dbReference type="InParanoid" id="A0A162URX7"/>
    <dbReference type="OrthoDB" id="2275630at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007840217" evidence="1">
        <location>
            <begin position="19"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD77463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="112" mass="11658" checksum="097E2D353A1177E8" modified="2016-07-06" version="1">MKTFIAIIGLLGLSLVNSAPLPGTQPSNNTLQALVPVSHTILGMYNNGIDPSMSNYTASASIELVNPPQPTEASEITVQYFSSDATSMPTPTNGALLATAMAVTTITFIIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UXU9</accession>
    <name>A0A162UXU9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_140749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296732.1">
        <property type="nucleotide sequence ID" value="XM_018430454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UXU9"/>
    <dbReference type="STRING" id="763407.A0A162UXU9"/>
    <dbReference type="GeneID" id="28991360"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_140749"/>
    <dbReference type="InParanoid" id="A0A162UXU9"/>
    <dbReference type="OrthoDB" id="2281895at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="364" mass="40466" checksum="09087EC1BE1B59CC" modified="2016-07-06" version="1">MSKFLIALILGPPLAFFTTKYIWDTLAEWMVDLIQMCIDAVYHDADNGIRGVYTGFKHLDMLATLYVSLFKFSFRIPIGRAVDQVMLSFCGVILAIMNVEGSRRNIASTPLSWTVVWAMIGNMCGVSAIFPVYVPLYLYYSPAPTGKNVSGYIVSPNRANAILITVLIGYFAPTAYMIAGVTPETHLEETFIALWQIGPLWTIPMCHAFEYLFDIISPITSNEKDKDLAERMAIVDSKNAVERLYLFLGVLCILVYYGTYIHLSWSGIKVWDALVELVAAPVTLPTGLTYFQVGGFLASYTFFMDLFSTLLGCVLWGVLDDGYTGAAILLLTSPIVGPSAATCIYAAYRENRLLDTRKLVKKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162VAT3</accession>
    <name>A0A162VAT3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_8100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299383.1">
        <property type="nucleotide sequence ID" value="XM_018443603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162VAT3"/>
    <dbReference type="STRING" id="763407.A0A162VAT3"/>
    <dbReference type="GeneID" id="29004508"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_8100"/>
    <dbReference type="InParanoid" id="A0A162VAT3"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF27">
        <property type="entry name" value="PHO85 CYCLIN CLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="102" mass="11783" checksum="3B59389F78413E05" modified="2016-07-06" version="1" fragment="single">FCQQLIKATQISCACIVLALYYVNRLREAYPFVQGSIGSEVRLFTTALVLANKYLDDNTFTNKTWADVSHIPVHELNIMEVEFLSALNYRIHVPHQQFFSWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WUP2</accession>
    <name>A0A162WUP2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_171054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289035.1">
        <property type="nucleotide sequence ID" value="XM_018436490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WUP2"/>
    <dbReference type="GeneID" id="28997396"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171054"/>
    <dbReference type="InParanoid" id="A0A162WUP2"/>
    <dbReference type="OrthoDB" id="2206543at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="677" mass="76578" checksum="C8034A849D092E14" modified="2016-07-06" version="1">MGSFLGDHAITSRGTSFLQWIQATGLTCWNELLAFGIPTFLSGGSGTSRSSVIDLFLSTSPLLNPSMQIRSDLSLGSDHKMVNLTFTPYVSPPPPPTNHPRLLWNLSKLAQPDTLKIYIDTASASLDNLTEQFSAFLSSSSPPPVDSLCSAFAQAIYDALDTAVGRRTPRTMQKYWFWPVDLQEAMDLRERSYQRWRHSSGLQKAICWMRHQDACHAVRLSVQRRRRETWKEFCNKLATQDFAKTTATMKRIKSHRQTSPVFVDPGGPQVDANKMADHLQQIFSGQFLPARRPPDQTVMISSPIAIDESCPFTHLSVESAILKLPTRKAPGVDHLRAEMLHPIVKQVSPVLCLLFQLSKGTIDPSLLISRNCVSAINSMRALQSLGVNHTGLSRLLSIRLYRQFIRPQFEYGLAISCFNIKQVAVLEKAQNTCLRMIFGGHSTSSTSVFRHLGNLPSMRERILTLGFKFVYRAFWLPDEALFTLLRPVLTNPAHQWFKLLANPIWLSLSNRQNADSKACKHAIRSFLNQGLFLQRSQQILLSACRPSLGVDPILWLPMTNYERSRFIRWRMGWLPGRPQPCSCGLHTTSRHHVIECTGAAIRLHLYSTVQPNPIDYVLNMLPLKKPKNNKNNAFWIFTWPILCRIMLDIEQICLPGVDLADHAATDRGQLFLNWLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WWC4</accession>
    <name>A0A162WWC4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peroxidase</fullName>
            <ecNumber evidence="13">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHYBLDRAFT_155800</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 Fe(II)-[cytochrome c] + H2O2 + 2 H(+) = 2 Fe(III)-[cytochrome c] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.11.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="13"/>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289255.1">
        <property type="nucleotide sequence ID" value="XM_018433440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WWC4"/>
    <dbReference type="STRING" id="763407.A0A162WWC4"/>
    <dbReference type="GeneID" id="28994346"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_155800"/>
    <dbReference type="InParanoid" id="A0A162WWC4"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004130">
        <property type="term" value="F:cytochrome-c peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF58">
        <property type="entry name" value="CYTOCHROME C PEROXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 13 15" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="14">
        <location>
            <begin position="96"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAD71215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="304" mass="34787" checksum="CA276E2E9CD4EE96" modified="2016-07-06" version="1">MTALGGAAGYYYHNSEKSIKKDIPQKEKAIDYEKIYKEIADMLEDEDYDDGSYGPVLFRLSWHCSGTYDKKTDTGGSNGATMRFLPESGHGANKGLDVARNLLDKVHAKHPEISYGDLWTLGGVCAVQEMGGPTIPWRPGREDALTAKQCTPDGRLPDGMKKQDHIREIFYRMGFNDQEIVALVGGHTVGRCHLDRSGFEGPWNEAPTIFDNEYFTALVEREWVKKQLPSGIWQWVAKENPDVMMLPAEIYMYNDKEFRKYFELYAKDQDKFFEDFAKAYKKLIELGVHFKDGDKEYKFKTVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XBF6</accession>
    <name>A0A162XBF6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_168141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291745.1">
        <property type="nucleotide sequence ID" value="XM_018435808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XBF6"/>
    <dbReference type="GeneID" id="28996714"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168141"/>
    <dbReference type="InParanoid" id="A0A162XBF6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="124" mass="14866" checksum="A511EEB9EEE85038" modified="2016-07-06" version="1">MGDWPGFHSRYHNPIEDAYFQKFKQVPSHHSYHPSRIPNVTCHGILRYTNPNFLEDMDQLLLKHSLWNRYFLFLKFRYILNRLRHDGTISGTFTRVIQVGSIIRLPEDVPDDCCVRQKLKRPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XCR6</accession>
    <name>A0A162XCR6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_145478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD74015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292055.1">
        <property type="nucleotide sequence ID" value="XM_018431450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XCR6"/>
    <dbReference type="GeneID" id="28992356"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145478"/>
    <dbReference type="InParanoid" id="A0A162XCR6"/>
    <dbReference type="OrthoDB" id="2289409at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="142" mass="16280" checksum="F35080DF09DBBE32" modified="2016-07-06" version="1">MLDNMDIEYLSLNEQGDSDYLTREVTVSLVSMMRAKYEYGLEAMEIDKVLLEEFSQEEKDEVEEKAEERENSNKDFEKISTSSRIEVFSNALTVKNNVKKESTYGSYDSDQISRFLSLVIEQVPVKDVAADAGITKSTAYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y3I6</accession>
    <name>A0A162Y3I6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_141971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD78105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296145.1">
        <property type="nucleotide sequence ID" value="XM_018430712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y3I6"/>
    <dbReference type="GeneID" id="28991618"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141971"/>
    <dbReference type="InParanoid" id="A0A162Y3I6"/>
    <dbReference type="OrthoDB" id="10443269at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="347" mass="38978" checksum="55D4DF58035EE1D0" modified="2016-07-06" version="1">MPSNATRKSGHKGKHNARGTLSRVAAGRIEQHEIAPRVSPLAAGPSGVEAPGMTVESLTQVMAAINMMYDPTVEANTGIRFLVDAHNQAIAQQALVASSVTQGVTAANVSTNRHTKGEMHAIVLNLINGRMWVRNFRSNDPELVAENKSRRQWNTAERIDHPDNVEVINYLRQYIIAQPRTAGFWEDMIVQKIKNNYKTCFRAVNATPEQASSKRRNNRINSHRIEIHLRRVDTYINNWLAIDTKMGYKPGNPDEMAYLHLLEKSVMSDGESEDEDVTPIIRVRVLQVARPSWRSAKLNRLIQFIDFLAAENDKKIATPQSKQRMPRYLKTIAVTPVPGHLTAILPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y7Z0</accession>
    <name>A0A162Y7Z0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_62364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296915.1">
        <property type="nucleotide sequence ID" value="XM_018440959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y7Z0"/>
    <dbReference type="STRING" id="763407.A0A162Y7Z0"/>
    <dbReference type="GeneID" id="29001865"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_62364"/>
    <dbReference type="InParanoid" id="A0A162Y7Z0"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="141" mass="16012" checksum="660D2F98E1014D9E" modified="2016-07-06" version="1">MLCPQDTSSKADKAHQKPNMGACKKATSAHKRGQSSKCAPEKGQTSPQERPKYVPEEKGKPAPQERPKYVPEEKGKPAPQERPKYVPEEKGKPAHKKGQSRRQSKHQSGLQERLMLQMRAREKKAFQRPSRSLSRFKAKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YA14</accession>
    <name>A0A162YA14_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="1">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_75483</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="1"/>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297335.1">
        <property type="nucleotide sequence ID" value="XM_018443060.1"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162YA14"/>
    <dbReference type="GeneID" id="29003966"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_75483"/>
    <dbReference type="InParanoid" id="A0A162YA14"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045520">
        <property type="entry name" value="GPAT/DHAPAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF45">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE CG8306-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19277">
        <property type="entry name" value="GPAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="4">
        <location>
            <begin position="170"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="860"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="domain" description="GPAT/DHAPAT C-terminal" evidence="5">
        <location>
            <begin position="1079"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD79295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1555" mass="174339" checksum="723E8281358AE676" modified="2016-07-06" version="1">MALDNLNGDELASSWSQEKQPEDSPHAVVERPVSVIVVNPEGMDAHAIMDDESTLETNTIDEDSNGVSTQASSIHDSAPTSPKDDKMPSDQAIETQIHAQDTPPTPTPTPTPTIQMQKQTNTPVIASATKPRPVDEVDEPSRFDLSALQNILPEFAGPVTRFYQHKNILLTGATGFVGKAVLWKLLQALGPNIGKIYVLIRNGSNKRSKVGRPTDRIRNEILSNKAFISLKRSIGADLFDAIVKEKIIPIAGDIISPDLSITEEDREMITRDVNVVIHCAATLDYHERLDLSLETNTLGTLRLMDLADECKNMQAFVHMSLAYLNANLPDGNIQERVYPMELGDPEELLKEIVGLELQDIPKATQRILGHYPNTYTFTKALTEHLILKRVDYNRLEEVQGGKTQWPVAIVRATQVGGGAYEPLPGWVDGVTGANGAIVLMGNGIQVLQPDIGDTKADIVPVDYLARIVIGSAAYIQPPGSKFLLPYNEILANNAPVGNSNIPHIQYFPIIYQVSATSIDSVSWRKVYESSRHYWMRTTKITLPTAKEHFVSNKTFFKAKIFMRNHMHQSFTSVSTTINTNIGVNGNTGNRSEPSLASRAIELATRVVEANQPFIRHRWQFENQNVKEMHSFLDDDYVFSLNGYQHINWERYVANYSYGAHIYITQGPPGSRSITVPLQWDCALYSKFSNAKNSIIDRQIESVIFSASDIEKRTERMLTQIIMSLEKPDNESRDKKMIEEWVNDFDASLDDWCHDDSEILKDGATTADLGRWSVSVGEDDQSLKVIVLNDKRVGNSIRQIIDTSGVPQQTVVGEAFKVLQRMKERTQLAYVWFAGAFLDSLFKNLFTSIRIKEGDLLKMKESIKGKNVVYVPVSKTILDQLLVWYICLRYHLPVPAIVCDEALALLGPISDILRIAGAYFVRRDQSTRSPLNTAVAAAYTEALLHDHGALSMLIEKARSRTGRLQTVYRDGVLDMIIEATLERNQTKPTSRQSTQLQAQYQEAYDNGSSSSLVSKGTLFVPINITYEKIPELRTLIDQVLDQKSRAGAASATRLTAPSTFLRPSASFVGRAANKDNGTVEQGKYGRVYIGIGDSVDLKQRVQEAHTEFEKDGTMAINEKQAYSTEYVAKAIQKHQHRAAIVSPVSLVAAAVLFGRATNGLPIGKIYEYVEWLRAEIIEKGISLDWQAEEDVETVVAYALNLLDAKTNIILDGKRITEFTNVRVMDHADNIMDLSYMANQLVEILLPEAFFAVLYLSTGPKRVSKDDLLRQFNFLVHLFKDEFVYPWDKEQEFYRLLEWYTKKDILTLAEGDNTYYKTLTMDSDHTVYTQICLIASFLYPTLDAYWITSCSLSALRDLPYIPRKIVPILSQWIAAHLISGRRTIYREVLSTEASQNAVDNFLVIGFIDAVHPKTKLSPDAQILLLELGVTTNEDLVMVSNRENISTESEVDSNKANAHEHPDSLSHLKDIAALCHEIERYRFGADAQTRNHGQNAQVFDKCQNQIRSILRAEESYATQHGMELIRDEDQMIQLVYSLKAGSGASNPRRVSEVYNLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YL23</accession>
    <name>A0A162YL23_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_138983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299475.1">
        <property type="nucleotide sequence ID" value="XM_018430122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YL23"/>
    <dbReference type="STRING" id="763407.A0A162YL23"/>
    <dbReference type="GeneID" id="28991028"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138983"/>
    <dbReference type="InParanoid" id="A0A162YL23"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="288" mass="32920" checksum="CE7EE2CD00818A83" modified="2016-07-06" version="1">MNVDNLENLQEIMQNTGTATNQINSGFHPSPDLQFMGLFPLINGDNDMISQRMLKKTLAAMSLIVKIHAETQTEKVFKLPRLDSILNYQTRKGNTIHALLSLHKEIQVPNNTEHVYLDLPSPQLKFIMSNLKKYNLISFLPDRTPGQAGSLQQGENWIARPLFQQPIFNVNGVDIWSGDIIYLMVDNPSLRFLVESFHASKNCAYPEGYMIRMLSDEFHGLESPSTAIDMERIGCVYNDCLEEACYLSILLQSTTRLCPTHHTLLFMQHPIKKNMLPMHRPMPFTKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZUW0</accession>
    <name>A0A162ZUW0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CCHC-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_73738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287211.1">
        <property type="nucleotide sequence ID" value="XM_018442906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZUW0"/>
    <dbReference type="GeneID" id="29003812"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73738"/>
    <dbReference type="InParanoid" id="A0A162ZUW0"/>
    <dbReference type="OrthoDB" id="2289614at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD69171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="237" mass="27037" checksum="A6BF1C934CB1C375" modified="2016-07-06" version="1">MNDEEALDKFVRGLHPTIRGNVLAARPVDVDNACNIALAYASGLHLGQQNNYAPVPQPYQQTYQQPYQQQYSGPEPMDLDAIQGRRNNYRSRPPQKRNVATCHWCGEVGHFKRNCRDRLAVIRQLDETRSKKQGFRETQPETSEPEINKDVSEQYTNVTNEEPETMSEENCDPCLTADQHFLEDLHAAVDTDLPLYAAILDGQQILVLIDSGANRPFGHTHFGYTRTISRNCRRTQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZX63</accession>
    <name>A0A162ZX63_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_149387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287641.1">
        <property type="nucleotide sequence ID" value="XM_018432265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZX63"/>
    <dbReference type="GeneID" id="28993171"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149387"/>
    <dbReference type="InParanoid" id="A0A162ZX63"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="119" mass="12891" checksum="1E5C12B5B69D3FDC" modified="2016-07-06" version="1">MQILSIQKRIISKCQRRQSSTNNTTSRASTFTSSMSQCIKGLASVKKAFSCNKVQNTVAPSLISSSSTISNASYISALSDDENFSKSCPVSEKSMALDSLIFDHPSVTIHITPTAYRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AAZ4</accession>
    <name>A0A163AAZ4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vaculolar membrane protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_169381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290281.1">
        <property type="nucleotide sequence ID" value="XM_018436065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AAZ4"/>
    <dbReference type="STRING" id="763407.A0A163AAZ4"/>
    <dbReference type="GeneID" id="28996971"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169381"/>
    <dbReference type="InParanoid" id="A0A163AAZ4"/>
    <dbReference type="OrthoDB" id="431202at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022127">
        <property type="entry name" value="STIMATE/YPL162C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735:SF1">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12400">
        <property type="entry name" value="STIMATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD72241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="31941" checksum="7750E5A31DA6709F" modified="2016-07-06" version="1">MFITPCQGNLNQETPPFEDDEGCKLLDSFAIIVQFTLAATALLTLFVKRYRERPQRPVPVWALDISKQFVGAVVIHFLNLATSYLAGRPKDGQKTNLCVWYFLNVAIDTTLGVAILWSWLHVIHRVLRYFDVKDVRSGYYGPPPLRRRAIPWIKQTTVFVIAESLMKLCVYGMFRAFPSLFDLGEWVLQWTRDNYRYQVVFVMLVFPLIMNAVQFWVVDTIVKVHPIPLDSPDLLKAIDESPSPYTPSGPPHNGKQTSKVLQNERTPLLKKVSSQDSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AHX7</accession>
    <name>A0A163AHX7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="11">ARD'</shortName>
            <shortName evidence="11">Fe-ARD</shortName>
            <ecNumber evidence="11">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="11">ARD</shortName>
            <shortName evidence="11">Ni-ARD</shortName>
            <ecNumber evidence="11">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ADI1</name>
        <name evidence="13" type="ORF">PHYBLDRAFT_145077</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="11">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="11"/>
    <dbReference type="EC" id="1.13.11.53" evidence="11"/>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291641.1">
        <property type="nucleotide sequence ID" value="XM_018431362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AHX7"/>
    <dbReference type="FunCoup" id="A0A163AHX7">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163AHX7"/>
    <dbReference type="GeneID" id="28992268"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145077"/>
    <dbReference type="InParanoid" id="A0A163AHX7"/>
    <dbReference type="OrthoDB" id="1867259at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000079">
        <property type="entry name" value="1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD73601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="176" mass="20855" checksum="C4A3AE2182B4373F" modified="2016-07-06" version="1">MKAYVFEKSEEDQREPHNSGTYVSAEDLAQIGVLYWQFNGEDALDRINDLAAERKYKNRDEIIVSPEAMGPVYEEKVKSFFAEHLHEDEEIRYILDGSGYFDVRDKNDVWIRIHLERGEMIVLPAGMYHRFTTDAKNYIKAMRLFKEDPQWTPINRPLADENQHRFDYLKTFNITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AN24</accession>
    <name>A0A163AN24_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CCHC-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_168012</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292651.1">
        <property type="nucleotide sequence ID" value="XM_018435781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AN24"/>
    <dbReference type="STRING" id="763407.A0A163AN24"/>
    <dbReference type="GeneID" id="28996687"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168012"/>
    <dbReference type="InParanoid" id="A0A163AN24"/>
    <dbReference type="OrthoDB" id="2417874at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="272"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="569"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="569"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD74611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1225" mass="139196" checksum="9BA0C95E1812B807" modified="2016-07-06" version="1">MWISSNEDNAVVFDITDSGLDAAQFFQALKSQYPSIVGALGQDRRDRNIAIISFDTIEDVPRASTPTFGRDSNILRIHLDKLPLRRADKLESQVQEVMGLFGRVIHIGFYMDPQFQLFGGKDFVMLDTAPKEGIEYIPLTHKIDFRGEQEIYAKWQNMPVTCNYCHREGHKKANCEKKTKSPRLCYGCKKPGHIRAQCPDETIEKERKRQCQEDPQVISPENGGNNHQLEEELACLVRENAKMQEALVQSENALEDKIALVEEQQRSLEGITESSEITVGPTTEAQGGIAESHTDTENTQSSISTLLQAQSSTWSHHCGLVSFNSEYYIEPHLNSFNPIHLTDGCLLTATIHYAHKIHDPLNFFVIYAPAHPEQCPLFYSLLDHYLAFSSPPLPKSVLLGDLNYKTRLTSSPPLPTTWTQWLSHHWFDAITPVNCTPLPTFTTGSTLDFLFVTNDLKISVHSPVVEYVAGSWMDHFSISIQLSIGSPQHGPGIWRFNPYLLSDKEFCNTMTTFLDVAETQIPNVAPHIQWDLIKANLKAMAIDHSRKARNKAKTMQKILPEQRSAIVTQLHSQSQRDLQSRHPSNPHSRPRTQHTQHISNREVAQEYLGTSQPQSHRIEDEPHTSPTPLTEEQEYVPNSLDDDPSSVLHQQLLEVERQIDCQQEAQNIQAQQENGGLTKSPDGLVKCAHTFYSDLYTAKTIDDNVVESLLANIPDSSCLPSEEGETITAEWDAKNILRALNHFPTRSSPGIDVIPYELLRWLFQHKFAQGLMVKVFNLALQRQEIPRSWKRHSSQPITYLDYPLTSSKAQLFCAFEDVITKIRNHAQFLAQQNLLVLGRGLVANSLLLSRAWHVIRILPVNTADISRLRSEILPLLDQTAPLSFAGKILAYLIRQYCNTTNSFLPLVFPELRSPRLNTFSIFPTIFHAMKTIPLSFDWTVINPVTVQELSLSTILAPSHPLPLFFTCGKLRACNAFLYDYTLGCICRLNQYERRRARSNIDTLFTLLDHSELRLKEWFSLLTVSPLREPGSVMASFFPTPPRHFQGFLSSGIPKVPQIRNLSAQVIRAHIRPPLTQVSPPFPHAALVHWCSFLELRLPLRIYTIWWRLMHGKTTHNAFYVANWKIMNIYSGHALIKKLIWHQIATRFLEYPTSLTFDHLLLPSSPMSVEVKNTTVSAYSILGCTIGAIWDAHFQHIFHDVPFVTNRIAAIATLNIRKIELEDSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ASY3</accession>
    <name>A0A163ASY3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_143815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293611.1">
        <property type="nucleotide sequence ID" value="XM_018431074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ASY3"/>
    <dbReference type="GeneID" id="28991980"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143815"/>
    <dbReference type="InParanoid" id="A0A163ASY3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="104" mass="11670" checksum="05D92C68E3EC33FB" modified="2016-07-06" version="1">MSSTCWEANCFLYSSKKTSHMVTLASQMAYHLAVMPQKWVATTRIVSSLVIPIPFFSQSICSNQKRDLLFRSLTKISGAKRYLEMLDDLCSLMGAEEEGAYCTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163CTZ2</accession>
    <name>A0A163CTZ2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_189538</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="3"/>
    <dbReference type="EMBL" id="KV441009">
        <property type="protein sequence ID" value="OAD65580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283620.1">
        <property type="nucleotide sequence ID" value="XM_018439675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163CTZ2"/>
    <dbReference type="FunCoup" id="A0A163CTZ2">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163CTZ2"/>
    <dbReference type="GeneID" id="29000581"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_189538"/>
    <dbReference type="InParanoid" id="A0A163CTZ2"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF33">
        <property type="entry name" value="ALPHA-GALACTOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="7">
        <location>
            <begin position="375"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD65580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="461" mass="52027" checksum="D19EC04058875E82" modified="2016-07-06" version="1">MGALAGPDRKDINIEPGCKPDWACKPMLGFSTWSTQILDDVPGYGGRTESPWFNETNIKEISNVMRQKMPDYEYINLDSGWSQECDENGRWMFRSELFPNGLKALSSHLATNGHKLGLYMLPGIRKDAADANLLVKGTSHRLGDLVTMKRQGNGFKDTTYMPDVHNEVVQAYYDSIADLFAEWGVSYVKVDGCGPGGGDQMYPYQSPDNRACLYMLATSFKQRNIWMELSWYLDHSYADEWAYIANGARIFIDIESYSTKTMTSSFRVFQRITQASRWADKVVVGKKYGFFLDLDVVVVGMTVDGNCIDGLDNDDIRLSYISFWALLSSVFCIGADPRKIPEKYLRMLCHPGIIAIHQSGIMARPIQSGNVWTNRKQIWWKKMENGKICVGLFNAHVYMLILGMNQGFVLNLTDVGITAADIEDVWTGQNLGTHKDTYKVYLRPGQCQILMLTPKTSSPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DII5</accession>
    <name>A0A163DII5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_170147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289510.1">
        <property type="nucleotide sequence ID" value="XM_018436261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DII5"/>
    <dbReference type="GeneID" id="28997167"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170147"/>
    <dbReference type="InParanoid" id="A0A163DII5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="151" mass="17783" checksum="904D70BD795DD973" modified="2016-07-06" version="1">MKQIINKKIKLAGTKQQTVDALKKSRKISEFIMKKNTGRVFIASIDELIKDILEVIKKEFNVKLEQMAAVKELEKNLKANKYIHKVDNVLSDLESKERTLGFFESLGVYSFKGEIRMCKRLFYICYKNLWILYEFCTFVFWCPQLQIDIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DYX2</accession>
    <name>A0A163DYX2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">KH type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_144719</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292310.1">
        <property type="nucleotide sequence ID" value="XM_018431273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DYX2"/>
    <dbReference type="STRING" id="763407.A0A163DYX2"/>
    <dbReference type="GeneID" id="28992179"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144719"/>
    <dbReference type="InParanoid" id="A0A163DYX2"/>
    <dbReference type="OrthoDB" id="188276at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22534">
        <property type="entry name" value="KH-II_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTPase_Era-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="GTPASE ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698:SF1">
        <property type="entry name" value="GTPASE ERA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Era-type G" evidence="10">
        <location>
            <begin position="252"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="9">
        <location>
            <begin position="459"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="83"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="6">
        <location>
            <begin position="260"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="6">
        <location>
            <begin position="286"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="6">
        <location>
            <begin position="307"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="6">
        <location>
            <begin position="375"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="6">
        <location>
            <begin position="407"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD74270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="61722" checksum="F8FA2C015132DF92" modified="2016-07-06" version="1">MTRAKHEAGVPLELIKPKKGARTSTARREQLRSQNVPEGILKKSENTWKTNGLAAHSTYDENKRTNWDREDKINSFNDIDFVNNRHRTSNNSRTHSSQGNRYDDDQAGFQRGSYRQNFNDNDHQNNRDYYGSTRERRYNNNNRRTESWDDGYDSRHGSESQGRNEYSRKENPDRNVYRDLDLKARKEYSTVEEGRIKENRTSTDRIKRERNTKEAGGYIPSVLNSMKTREPAGLSQRLIKIVQNVTQPENPHSVKVAVIGEANAGKSTLINKIVGEQVTVVSSKAHTTRERILAVLSQDNYQVVFLDTPGIVPDNSGIKMNRTLLTSAWRSLDEADHVVILVDSRKALMPEARLAEESIIAQLKKYSIPATLVFNKMDLLDSDDTILEEVTARYKEGYCHIKQTLYVSALKESGLTKLKDSLFSVSQPKEWAYPKELKSEMSDLKRVEELIRVEFFKRLHQYIPYMLKQENVGWTETEKGIRIDQTVYVERDSQQKIVVGAKGAVIDQVVQEARTQISLALNRPVQLYIQVRTKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EB13</accession>
    <name>A0A163EB13_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_185600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295760.1">
        <property type="nucleotide sequence ID" value="XM_018439102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EB13"/>
    <dbReference type="GeneID" id="29000008"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_185600"/>
    <dbReference type="InParanoid" id="A0A163EB13"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="53" mass="6183" checksum="476BCF6A228356B4" modified="2016-07-06" version="1">MSKPVHIKNEILRSNTGLIINPSKTYPRSETRDKLSGLTIFQTVYDIHQRHTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EE69</accession>
    <name>A0A163EE69_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_60396</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD78150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296190.1">
        <property type="nucleotide sequence ID" value="XM_018440636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EE69"/>
    <dbReference type="STRING" id="763407.A0A163EE69"/>
    <dbReference type="GeneID" id="29001542"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_60396"/>
    <dbReference type="InParanoid" id="A0A163EE69"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053019">
        <property type="entry name" value="GATA_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23353">
        <property type="entry name" value="RAB-GAP/TBC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="571"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="571"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="640"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD78150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="725" mass="80434" checksum="DF10A2300AB90CE7" modified="2016-07-06" version="1">MHNPRLRDNVSTVKASSPLSGTTRKPAITATTTANTTNSSSSTSPDHVDQILVQVRRQIERWGEHARWHINLVLLDPPNSKPGSPLPHKGLSPVPQKNSSPGGDTGARLQSLFQTQYGTGAGSPQPPALSIFGGGATGTHSPWCILIDISVVCICALCFYLKWEYSIPSTSYSYTRPNLDDAQQKLQDAYDRQHHLESIVQSQADQMKLLGDHPHDTEKAIETMRTVYLMTENEQKLRHALETRMLQTEIDTLARKLRRVGTTLRTVENIELSAEETSMDSKCLLEERKLMMRKLHLAELRLSARDAELDYLHETLRAYNAHAAHHEPPISRQSPTLQKQFRKGPPYLFQQQYSPKIRSDLRPPAQQSHLMSGLDSLGILADQMLSNPDFEKKETQGDTIAGKNTSTDLETDTDTNFAQSSPTTWSIPAEPRHFDLKRSKRSIDSANTLVAMPSLAITSSDGRESNHVNYETSNNNSPIHTHNHHNHNHHSSNINNNNNNNNNNNNNHNNHNHNTTVDVRGSPSDSHFTTTSTTTAITAAIPSSSSLLLLSSSPLSSPSSSLSLSSSTAKKARLDSVTWTLEDDLALRQAVDGLGTNQWEKVAATIPNKTLQQCRQRWSDLCFQLSSPPQPQPQPPPPLSLSLSLSLPQSSLPENFSPSLSSRPFNARRTPSIAALLDSNEDMQMRQNNYSFRLGSPLSRHETNPSYCRSPPHPPQGTGHIQERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JJB2</accession>
    <name>A0A167JJB2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_175622</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Lipid-anchor</topology>
            <topology evidence="10">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KV441006">
        <property type="protein sequence ID" value="OAD66099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284139.1">
        <property type="nucleotide sequence ID" value="XM_018437529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JJB2"/>
    <dbReference type="FunCoup" id="A0A167JJB2">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167JJB2"/>
    <dbReference type="GeneID" id="28998435"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175622"/>
    <dbReference type="InParanoid" id="A0A167JJB2"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF2">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9 10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007749195" description="1,3-beta-glucanosyltransferase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="11">
        <location>
            <begin position="383"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD66099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="503" mass="55737" checksum="4EA386896D0112BC" modified="2016-07-06" version="1">MKLFFLVLVFLAGSVNALHPIIIKGTRFFDKVTQEQFFVKGVSYQPRTNHVLIDPLADPVACRRDSALMAHLGLNVIRVYEVDPANNHDECMKSFADAGIYILLDIATPKFSVNRARPEYDVRLLQAYRATIDAFGDYNNIFAFLAGNEVTNDKTNTLASAYVKAGVRDIKRYLRDTRRYIPVGYANNDDGDIRDAIRDYFSCGDPDDQVDFFGVNLYEWCGKSTFEKSGYADRTREFDKFNKPVFLTEYGCNLVSPREFGEVEAIYSPAMTGVWSGGVVYEWTQENNNYGLVQQNPTNLTLLPDYTNLKDALSRVSPHKTHLQDAPESGQEQVDCPGLSEVWKASSILPPTPLNETCTCAKQNVVCTASDKIPDIEDRTTGIDSNSSLVVGAQIDMLCGLVSCEAIGGDASAGLYGVYSGCSPKQKLSLLYNEYATMTGTCDFDGFALEATPHRTSEDCSNKDKNRVFRPKPSLVTPTEAVAGRLRPSIILVVGLVLVFMLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JLU1</accession>
    <name>A0A167JLU1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PDEase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_90638</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441004">
        <property type="protein sequence ID" value="OAD66269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284309.1">
        <property type="nucleotide sequence ID" value="XM_018443759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JLU1"/>
    <dbReference type="STRING" id="763407.A0A167JLU1"/>
    <dbReference type="GeneID" id="29004664"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_90638"/>
    <dbReference type="InParanoid" id="A0A167JLU1"/>
    <dbReference type="OrthoDB" id="546632at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD66269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="289" mass="32562" checksum="159CAD38C1F896AE" modified="2016-07-06" version="1" fragment="single">ELNVLDLSRTDVLGLLLAIFQRLGILETLATCHSSLLDFFVDVYAAYVDAPYHSFYHAADVVIMLYYLLTDLGALVHLSALDTTSLLLATLCHDVGHPGYNNTYQVGFKTDLAAQYKNISVLESYSIDITRRLLTKHDLLKHSKQVSMVERIERLILSTDMVYHEQLQQQTSNSNSLEITMMDRDDRQGLCRVLLHAADISNTVRPWPIAKQWSDLIVQEFFRQGDAERRAGLPVSPGMDRDLSSQADISLGFGDFVVKPYFEAIAGLLPAATVLVDTLKSNRRQWDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JZT8</accession>
    <name>A0A167JZT8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ndc10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_70352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD66997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285037.1">
        <property type="nucleotide sequence ID" value="XM_018442262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JZT8"/>
    <dbReference type="STRING" id="763407.A0A167JZT8"/>
    <dbReference type="GeneID" id="29003168"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70352"/>
    <dbReference type="InParanoid" id="A0A167JZT8"/>
    <dbReference type="OrthoDB" id="2415218at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.20">
        <property type="entry name" value="Centromere DNA-binding protein complex CBF3 subunit, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038279">
        <property type="entry name" value="Ndc10_dom2_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD66997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="783" mass="88689" checksum="591F07B0EC909CA7" modified="2016-07-06" version="1">MPKKACRGRPTKRIMLVENSKAKSSRSANLSTSVGSNTIVTSLNTSSSNVPEFDFALKTFANEITENAASNKNGSKKVIEVPLGIAAVNQYKKVLMFLHEFRSERREAEWPSPKKTKEVIELIKKYEHDLVYDQNQDLRNLNFANCFCTIIPKKQHKAIQQALALVSSLDKGKTLKEGEIKFACAMRHENIFRSPFGAFVFFMFRLLQVLRGRISPEKRLTGASQWKTAKKALADKEIYTTRVTPGGRHDGSMEAEGLRIPFHSIKPITWVNSHLLLREIKDYFGVGNTEWIALCEKEMDEANENIINLEIDKEADSVEFVEEDGRNRSKEKKRKGKQKTIQSSINTEKKGFLQLLIRCRRIVLQDAAVYLYLNKENKHVSTKKLPFTSNSFKMFQEDIVAAITSPSVGRLEEYESLVPKIADTNKEVASRVTEVNHWIIQLQQQQDSRFEKNENSFNNFIEQSNQQNWLLMNTTQQLAKDIKILMIQQQCLNSQMQLLMATNNIPQSINTNTRKRSEADTVFGGKNHFPQILSNYIGSYFMNKLQYSHLIEKMAPVNHRTSRPNAGSSLTQVAAGRVEQRPVTPAVTQEQHMAEMTNRLDGMGALLGSLGSRFVAAIAMSLASNNRQVLPVVTTSSAPSYIGMSEAETKTAILIHNRRQDIHTKYWKVIDKEMGLTIGENSEMAFFGAIQQTVMSDDEFYMEDLVHGVSAHILKFNKFMGLIDKSMRTDNAGNGAATPKMPKLQRGEKNVAVSGRLILSLPSWEIKQFFYTYTGAFLHLIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JZU3</accession>
    <name>A0A167JZU3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_183712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD66998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285038.1">
        <property type="nucleotide sequence ID" value="XM_018438818.1"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167JZU3"/>
    <dbReference type="GeneID" id="28999724"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_183712"/>
    <dbReference type="InParanoid" id="A0A167JZU3"/>
    <dbReference type="OrthoDB" id="2242379at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF160">
        <property type="entry name" value="ERAD-ASSOCIATED E3 UBIQUITIN-PROTEIN LIGASE COMPONENT HRD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="701"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="714"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD66998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2042" mass="225259" checksum="9615BA218BEA5C50" modified="2016-07-06" version="1">MGSNTSKPLDAQNNDPASSHAQSPQRRRTKLGSIRQPKNKISKGNLGRREPTILSPDTLPLPASCTRPSVQSAKSTPLTGATIQRSAEQNTVASNTTTTSTHPINSKLTSSTTPPSGPDGFANHNNHNDHTVGLDSNNLNSHNLNNPNHPSSLPNARISLVSQSSYVGMTQSREPRQRVPRGRNPQNRYSQRVYSNISCATSDSGQSSWMLSGGLFSQIDSTTSSIITTITDYSNISRRSMFAQDWPKEDTSKMVISASETTPASPIKPLSNLQESALISVQPEQTNNNPKSSPSLSLSSSSLSLSLLISSQAQTLTLSLLDQLNNSPHQEFSILKAAFAKSQQTGYAHHQEEAFRAAFAWSQRTNSLTGRVWVARCQIEGWGTSADPSHGFSTLKAIAETDDYWEAFYPLAMCYLNGVSAVRNHQELSSSSSSPPPPPPPITTAAVVAKSSSSSSSPSSSPSLALSANVITHNEPYSVQPIDNQTAFRWLKATAEIDYASKGTDPEIRSIVAKAQYRVAVMLFKGAEKMAQDPVGALQWFIKSADNGDKYAQYITGLHYERGMFTEKDTLKARSYLLQSANQDFGDAQAALGIACIEEGQDKEGMQALLKLGLMYETGQGVEKNDAIAVSYYKSAANRDDARAQYVLGLAYYMGNLGLQKNFGRAEKYFTLSAKAGYAPSQRILGLMCAQDLLGFSSDLSESNNTNDNNNNSAGGGGGGGGAAAVSRRKDRERDKDKDIKAALTWFRRAAYQGDIRALGLVGFCYENGHGVAANFETALEYYRKAARITGPFQDSAQLALAHLLHRMERHRDALNWFNRAAASWSAEQPPIGSAESAKSDPLQLLMEHRVASRTAALMVARYQLHGWTGASKRPKAAFDILFHLARQSELDSHAHYWLAACYEEGVQGRCEKDLSKAFEHYLVSAKAGDVDGEFQVALMLSNGQGVEQDRAAAFYWYEKAAKKEHKTALYSLGLYYAKGMAGVTKDLFKARSCFKRSARLGVVSAMTTLATLYKMTASRIDPSQDPDETETQSQSQSQFLEEQQRQAVYWFEKAAQYGDAVAQRELAILYDAGIGVNQSYAKALSYLQKSASQRDTQATLLLGNYYQNGHAVEKDLSQAIELYLEAADLGSPVAPFAAAQVYHALKQYEEAYAQYKIAANDPRLANARVSKASKLMVARYALSYVPLLSSADSTEVVSQDVEKMSKKDAFQMLYNLATEDQFESSYFWLADCFYMGNGVAINYPQALMWYNRSVEATRDAEAMAKIGSIYEQGLGGVEKNERLAIDYYKQSADQGSAEGQYKMGLANWRGMCGVPINLGDAVLWFTWSAKQKYPDSHWALGQMALENGDQDVATEWWHKAIALDHIPSMRSLASLLLQTSNQTQPQTQAQAQTQTQSQTGVVTPNSHLEHAMELLANAFRHGDAESLVDLGKLHQRGIVTQADSNSSNNSGHPTVLLLQPGFLTPKQQEEQELATRCFEEAAAMGHVESMFLAAESWHARQQYAAALGFYEKAAHKGHISSRAMVAHYRLKGLGGIEADPSSAYKDLLYCAEKESSSAVFNLIGQCNEHGLGTPKNYQEALEWYLRSSRKTRDPEAMFRVGQLVARRQAAIQRDEEDHLISSSLPSTGLNPDLQALEWYQLSIDTSDHGQSHLRAGLYFSQGIKDKKTGKILLAPDANLAIEHFRKAASQCIPEAMFELGQFFLLTTGARPSPRETTVMANEGVKWLERAAQLGLRGAQRELGKLYHSGHTVMTYPQVQENENEDEELEAIDVVNREPNLPVVVVAQDFAKAFDYFCRAAQQKDKTASLFLGIYHENGIYVQTNTELAKEWYRIAVVLGKQQEQKSRGSREDGGEDGWWLAELALAQLLHQEPVNRHEAYPLFEAAYCHAPLHQKRTALIMVARYRLHGWGNVAVNLEEGASMLVRLANEGEVKVFLEVAQCYEFGIGVEQDFQKAFEWYQRLVVGLDNMKNDDDEGDSDQVSACLDEEDVEDQAEASFRLAEFYKSGLVVSTDLQKANHYYRVAANKGSLKAKESLKQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K815</accession>
    <name>A0A167K815_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_69321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285490.1">
        <property type="nucleotide sequence ID" value="XM_018442078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K815"/>
    <dbReference type="FunCoup" id="A0A167K815">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167K815"/>
    <dbReference type="GeneID" id="29002984"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_69321"/>
    <dbReference type="InParanoid" id="A0A167K815"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="115"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="338" mass="38343" checksum="5B412525D0BE4AC4" modified="2016-07-06" version="1">MGIMNSLRGIMKPSASLSSSSNSSCKSKASCQVHVACQIETMQSTSNLSAISTQRPSYRFEHGRRYHDIEDSVYVLPNDDPEIDRLHQQHWVLHHAFDGNFSSPVHKLLEEGAVVLDSCCGPATWTLDMAKAYDRSEFYGIDISPVFPEDIKPANTHFQLANITNRLPFPDNHFDFIHQRLLIFGLTRSDWTKAIDELLRVLKPGGWIEFKELELNLENTGTMTTKLKESMITMTTTRDMNPTIGRELRLLLIQRGLLNIQAKRISVPVNHDGKIGELFWDNYKQMSLALAPVISGSLPLDFPQFLDSCAKECAKEKTNWGWHVVYAQKPVSPIRFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KPF4</accession>
    <name>A0A167KPF4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_172997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286616.1">
        <property type="nucleotide sequence ID" value="XM_018436923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KPF4"/>
    <dbReference type="GeneID" id="28997829"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172997"/>
    <dbReference type="InParanoid" id="A0A167KPF4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="104" mass="11753" checksum="0531993CB2EAE13B" modified="2016-07-06" version="1">MKETHSLSHSDAPSSQQLSRLARVNEHPSYKRAIPQELPSHATVIAMIISWSAKKSFAFVKEIIIPCFTVNVLFLCPFVLGTSNKNFHPKYNKITKQEVADNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KR92</accession>
    <name>A0A167KR92_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_117188</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="8"/>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286728.1">
        <property type="nucleotide sequence ID" value="XM_018428570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KR92"/>
    <dbReference type="FunCoup" id="A0A167KR92">
        <property type="interactions" value="213"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167KR92"/>
    <dbReference type="GeneID" id="28989476"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_117188"/>
    <dbReference type="InParanoid" id="A0A167KR92"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000048">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD68688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="177" mass="20229" checksum="1229644C0EA93BBF" modified="2016-07-06" version="1">MSDIALFDHNLISPEVQAALPPNHTIRALRSGDYERGFLQVLEVLTEVGNHTKEEWLERFDYIKRHNHECTYNFTIVITDDVKDRVVAAGTVFVERKFVHKNGLVGHIEDIAVDASQQGKKLGLRIIHALMHIGAKRGCYKVILDCSAKNIPFYEKCGFTQKEYEMAWYVPVKKASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KVQ0</accession>
    <name>A0A167KVQ0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_67095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287039.1">
        <property type="nucleotide sequence ID" value="XM_018441737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KVQ0"/>
    <dbReference type="FunCoup" id="A0A167KVQ0">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167KVQ0"/>
    <dbReference type="GeneID" id="29002643"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_67095"/>
    <dbReference type="InParanoid" id="A0A167KVQ0"/>
    <dbReference type="OrthoDB" id="5560525at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21044">
        <property type="entry name" value="Rab11BD_RAB3IP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF0">
        <property type="entry name" value="SEC2P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25555">
        <property type="entry name" value="RAB3A-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="4">
        <location>
            <begin position="27"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="32"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD68999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="470" mass="53727" checksum="374BF2B7A7A5F017" modified="2016-07-06" version="1">MDLCDVDEANSTVTKCNHCNRICLTNDEHKALVSQTDEIRDLKQQLKSQTEAFERLQLDISTLNKKYVAAIERVADVQHEKDLVEHELEELSRKLFEEANGMVATEKREKWELENQLRQTQEYLVSEQSQLTELKERMQAMLVSEDLSPAQNQNDPRTRAQNDLQELYGVKRASTNPTLYRKNISSDPTQRVTSMPPLQSQPRIQRMVTIDEFQLNKFQEYINSSRSVSVKKLSQFAYLKYCQAEDIEPCLRFGPQSRLSVKKMMDYLMRQPCFIEQMPLDDNVAPKSTLVTPISITTQRPLWERFSNSKILDGGCSACGRSAGQDCALKYRFKLDSSDPWLPIDEYCRDRLVAVCEFYVFLRNIQLGLYSDRPVQDLYAENIRLRLQMFYSRMGALPVMLEGMGMSPDTIGKASVPLETLATIPDDAYTSDTSASSGPCTPIRTNLSILSSVAYQNEPWALDSSQSQPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KZI6</accession>
    <name>A0A167KZI6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP synthase subunit beta</fullName>
            <ecNumber evidence="14">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHYBLDRAFT_188399</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="14"/>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287276.1">
        <property type="nucleotide sequence ID" value="XM_018439496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KZI6"/>
    <dbReference type="FunCoup" id="A0A167KZI6">
        <property type="interactions" value="309"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167KZI6"/>
    <dbReference type="GeneID" id="29000402"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_188399"/>
    <dbReference type="InParanoid" id="A0A167KZI6"/>
    <dbReference type="OrthoDB" id="14523at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000004">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="182"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAD69236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="513" mass="55371" checksum="87F4A35C4EDA414D" modified="2016-07-06" version="1">MQIHRFLTASRNAVRATRANAASLAQASARTYATAAVATATPGQIRSVIGAVVDVQFEQDNLPAILNALEVQDHTGGRLVLEVSQHLGENTVRTIAMDGTEGLVRGQKVVDTGAPITIPVGKEVLGRIINVIGEPIDERGPINAKSSRPIHAEAPEFVDQSPTPEILETGIKVVDLLAPYARGGKIGLFGGAGVGKTVLIQELINNIAKAHGGYSIFCGVGERTREGNDLYHEMMETGVIKLEGESKCALVFGQMNEPPGARARVALTGLTIAEYFRDDEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLSTDMGGMQERITTTKNGSITSVQAVYVPADDLTDPAPATTFAHLDATTVLSRSIAELGIYPAVDPLDSKSRILDPRIVGDEHYKVATQVQQILQNYKSLQDIIAILGMDELSEEDKLVVERARKIQRFLSQPFAVAQVFTGYEGRLVPLQDTIRSFKEILDGKHDGLPETAFYMQGDINDVIKRSEELAKEMGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LE87</accession>
    <name>A0A167LE87_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_87681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288298.1">
        <property type="nucleotide sequence ID" value="XM_018443671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LE87"/>
    <dbReference type="FunCoup" id="A0A167LE87">
        <property type="interactions" value="1240"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167LE87"/>
    <dbReference type="GeneID" id="29004576"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_87681"/>
    <dbReference type="InParanoid" id="A0A167LE87"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="508"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="57"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD70258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="539" mass="62210" checksum="35F3D4B77926E27F" modified="2016-07-06" version="1" fragment="single">LILGEYMIVITGRARIGSLCGSDIYRATTFQILHVPHTMPALTKQQMETEQMFINLLEDHLKQNSFYFSYKYHLTLTIQQQAALGQNSRSQWEEADTRFFSNRFLMEKLINATQHKTNPQDSYLCAVVVAIVSSVIQRRQVVFGLISRRSLERDGTRYFSRGLDIKGHASNFVETEQILLCDLPQSLSTTEHPLQFSFVQTRGSMPARWGQIPNTRYTPQLWLNNDLSNLDVLDISRTHFDQQIEHYGSQVLVNLVNKKGYELPVGELYRSIVEKLANPRLFYVHFDFHHECRKMRWNRVQLLLDMLEPELRKQSYCFYDATTPVLKKRQTSVVRTNCMDCLDRTNVVQSALAHWVLDLQLREANVLQSTEVVENDEAFISIFKNVWADNADVLSIAYSGTGALKTDYTRQVDLMLLTGKRSYAGALSDLSNSILRYIKNNYMDGSRQDAIDLYLGNYRVGKGQLDINTSGKSWQIRVIPPAFFLSFATFVFALFFPSHLAIESSLLYLFLLSFCFAIVLVTWRFIQLHGSEFVNWPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LEY6</accession>
    <name>A0A167LEY6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Needs CLA4 to survive protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">UBA4</name>
        <name evidence="14" type="ORF">PHYBLDRAFT_177975</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288347.1">
        <property type="nucleotide sequence ID" value="XM_018437934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LEY6"/>
    <dbReference type="FunCoup" id="A0A167LEY6">
        <property type="interactions" value="487"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167LEY6"/>
    <dbReference type="GeneID" id="28998840"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_177975"/>
    <dbReference type="InParanoid" id="A0A167LEY6"/>
    <dbReference type="OrthoDB" id="10261062at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070566">
        <property type="term" value="F:adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042292">
        <property type="term" value="F:URM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000014">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000033">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03049">
        <property type="entry name" value="MOCS3_Uba4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028885">
        <property type="entry name" value="MOCS3/Uba4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF102">
        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rhodanese" evidence="13">
        <location>
            <begin position="319"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate; for adenylyltransferase activity" evidence="12">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate; for sulfurtransferase activity" evidence="12">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="92"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="153"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD70307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="417" mass="45406" checksum="5CD36D63E909B0FC" modified="2016-07-06" version="1">MTSLAEENARLRKRIAELEAQLGPAPQSAKGSFKKVDALSKEEILRFEQLKLRNTTILVVGAGGLGAPAILYLGANGVGRLGIADPDTVAVNNLHRQVIHTEASTDTSKAESAMRAVHAIDSTCEVVTYPFALTSENALEIIREYDIVIDATDNIGARYLLSDACVLANKPLVSGSALRMDGQLTVYHHNNGPCYRCLHPVPPPIDTVSKCVESGVLGVIPGVIGTLQALEAIKVAVGLHNDDPSFLIFSGLTTPMFRTMKLRGRKKDCIACGDNPSLTDLIDYAEFCGTADSDKSQDLFLLAPHERIKACEYDAHVRQQKPSLLLDVRPPVQYDICRLPESHSVPIDEFENKIMDIKKSMSELDVAGDQVFVVCRLGNDSQLAVRLLEKHGIKGARDLVGGLYSWSMNVDPSFPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LG60</accession>
    <name>A0A167LG60_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_135446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288419.1">
        <property type="nucleotide sequence ID" value="XM_018429719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LG60"/>
    <dbReference type="FunCoup" id="A0A167LG60">
        <property type="interactions" value="104"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167LG60"/>
    <dbReference type="GeneID" id="28990625"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_135446"/>
    <dbReference type="InParanoid" id="A0A167LG60"/>
    <dbReference type="OrthoDB" id="2427554at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07992">
        <property type="entry name" value="LPLAT_AAK14816-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="2">
        <location>
            <begin position="41"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD70379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="561" mass="63052" checksum="A4086ED278F8E12D" modified="2016-07-06" version="1">MDPRKLTYDLTMWLFNLIIKLFFREVRPRGAHRIPKQGPVIFVVAPHANQFVDPILVMRECGRRVSFLIAEKSMHQRGIGFFARMINAIPVVRSQDLAVLGKGRIQLLNCKTEPFRITGIDTQFLSQLKPRDSIVLPKNVGQAEVVEILSDTELVIKKDFKDLKSLELLTSNDGTPYKCMPHIEQDAVYKSVHDELNNNGCITIFPEGGSHDRAEMLPLKAGVTLMALGAMAKYPGLDVKIVPCGLNYFHAHRFRSRAVVEFGNPITIPANLVDKFIAGGVEKREACGKLLDTIYNALKSVTVNAGTYETLMLIQAARRLYKPAHRKLHISHVVDLNRRFLIGYNLFKDDPKVIDLQQRVLAYNQLLKYHGIQDHQVSKTDLGGRHTLAMLIERLFFLSLLGLWGFPGAVLNLPIMVVAKVISEKKASAALRGSTVKIAGRDVLATWKVLVALVLVPTLYAFYSFIVFMTFYNSDLAPKWKFMIPGTVWVLLCFTSYASLRFGEIGLDILKSLKPLVMSLLDPDGAEILRQSRSKLSRDITDLINEYGPKAFPDFDGMCPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LZ20</accession>
    <name>A0A167LZ20_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CCHC-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_170751</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289426.1">
        <property type="nucleotide sequence ID" value="XM_018436420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LZ20"/>
    <dbReference type="GeneID" id="28997326"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170751"/>
    <dbReference type="InParanoid" id="A0A167LZ20"/>
    <dbReference type="OrthoDB" id="2202398at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD71386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="439" mass="47915" checksum="24B268F7FFD35F55" modified="2016-07-06" version="1">MALPATTPPPLPRDPSPPPGSPTPSLNTPSTPTGSPPLSPSYVAAAVKSVDNSCTSRIIDSIAGNGAPRIWKEGSSPFSVFYEVPAEGNPLRPLFFEALNTAFLLGVGRGLTYASRTSRTSFEFHLVGQEACSRACQVGFPFNGRTVFASPAIPSTFKLLRLRVSRLPLHGYADFDELAENLRRCLAIYGQVQEISLNLKYNYPDGTGTIHMLRPPNPDLHMRHLEHEIKYNETTTFLATWARMGTHCTFCKEMGHEKEACTKRPKETRTCFRCGKVGHLAHQCPRNEEAESKRPRKTARSPTHAPAPPAAQMYHGLLPSETIYGSQHAPQNIPLPPLATESLSRPRAAPGAIPGVLPANHPDFLIEAAASTGMDDNVQLVKTSDGELGNEETKKSDDEEYYSDDDIDEVAKYFAQMENDPMDGENDGGQDPPNPALTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M994</accession>
    <name>A0A167M994_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_71228</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Prevacuolar compartment membrane</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VTI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290219.1">
        <property type="nucleotide sequence ID" value="XM_018442432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M994"/>
    <dbReference type="FunCoup" id="A0A167M994">
        <property type="interactions" value="545"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167M994"/>
    <dbReference type="GeneID" id="29003338"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71228"/>
    <dbReference type="InParanoid" id="A0A167M994"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15862">
        <property type="entry name" value="SNARE_Vti1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.400:FF:000001">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREs homolog 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="132"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD72179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="202" mass="22598" checksum="AE8BD0F213C3D5CA" modified="2016-07-06" version="1">MASSAGGSELFTNYEQDLHALTESIKVKIDKQIPSQSGEERKAIIRAAEREIDETDEILGQMEMEILNIPAPGRTRLQAKLRLYKSEGEKLKRDLRRATAAAPRSNDRNELFGDLNDSTSDLDASTMDQRQRLLSGTERLGQSSRRLEDSHRLALETEGIGINILGTLKGQRETIVRARDTLAEADSYIDKASRTLKGMARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M9Z5</accession>
    <name>A0A167M9Z5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_71184</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290269.1">
        <property type="nucleotide sequence ID" value="XM_018442424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M9Z5"/>
    <dbReference type="STRING" id="763407.A0A167M9Z5"/>
    <dbReference type="GeneID" id="29003330"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71184"/>
    <dbReference type="InParanoid" id="A0A167M9Z5"/>
    <dbReference type="OrthoDB" id="5597995at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15047">
        <property type="entry name" value="7tmC_GABA-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF20">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 156-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007890216" description="G-protein coupled receptors family 3 profile domain-containing protein" evidence="11">
        <location>
            <begin position="29"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="481"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="551"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="644"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="682"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="707"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="12">
        <location>
            <begin position="482"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="752"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="987"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="767"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="995"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1020"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1048"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD72229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1071" mass="119976" checksum="3056A20EF0D56690" modified="2016-07-06" version="1">MKWQKIRANQRKTVLAFMLLVYTALSHAAMTSSTVNSSLYLEPDAFPTYRIGILYPDVTKLLPADVSLRNMIVASETAVHMLVDKVKADNRYPDFNITIVRYYSDAYNQGKSSWEATGMIEDGIDAVVGDISSGLTEMSASVTGIWQLPQCSSSAAELYLSDKDAFPYFFRTIVNSNQFGEATVDWVYNMNWTSFAVLYSNDYVGQQALFSVTERASALGIDPLVQVSLHDYEDSHIRESLLILAEQPTRIVVFPDLDPSHQVPVLKLAQSMGLLSEGWAWIITNDISEELKASTSSPEEYALYDGLMMISGLWDLTGQPAYDDLKKRWENEPVPAELISTEPKLWKTQGLSYNAPEAYACAELLVLGMDKALNLYPGGRSKGLSDLKARTFNSSNMTPTFFNMNYTGPKGLIEFSSTGDTTKGHLNFRYFILQYIKSGEVLTYANIIANVYELTLVSINSDLCILFICNCIALNPSADKAIGIVILALTMFGIFCCVVMVILIGLFRNIKPIMAASPFFCYIQLLGLAMSYLSVTLYIDMPTPSKCISRKFIITIAFVLVMTSIIAKNYRIYKIFQNVFTVRTARLKSLYMMRFVGTSTLVIVLPLIVWNSMYKIAVEEIVVGTSDSCFLCNYPTTTADWAEITIAELVVLIMCAFLIIISALLAYKTRRVRGKWSESNQIAYVSYNACLAACLATPSLFLGSDNYLVAIYLKLAAILFASTFTLIVLFAPKLVEIVKHITESSSLNIWGKAPKSHKPNNNNNNNSTSRGDGNITTDEQYSTASSSEFRINNLVAKNLLDFVMEAYEGVLPVKQELRFDLFSMWELKQLMVVPLKRYFVLVNQTDQRARKYTYTLCEQISAGRNIYIFRVTTDKQQIFLFQVNDQIALDRWIQWFKGPGADNGVPSAVRILSETNHNKVGGENNNPHHNQEYNHDHDHHFNYHHSDKALLSQAAAPITTFGLMEPDDIQMVPSNFVAQRSFGVASAPSTDLIGTSTSDYYQSSQTGGGRNRESLFTDTNPNYSNPSYNLPQDDIGSFQFPSKPSPLSPYSRSNYSSPNNTTPKSDWPRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MKE9</accession>
    <name>A0A167MKE9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_146412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD73099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018431641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MKE9"/>
    <dbReference type="STRING" id="763407.A0A167MKE9"/>
    <dbReference type="GeneID" id="28992547"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146412"/>
    <dbReference type="InParanoid" id="A0A167MKE9"/>
    <dbReference type="OrthoDB" id="10686076at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="56"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD73099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="217" mass="25274" checksum="4569096CF5F8BF44" modified="2016-07-06" version="1">MSNNGTMSSFTRQQRIREMEAEEVNDDARETMIVASVSAEDSSWQVQSFVDENTAYVVEVTDRLIMKCTCFDFERRQKPCKHMYLLKMHTAFSLHFSTTPLNSTYEHNVIPIPQPITTNNCSSLFFDQCIQTNQTLHQSHQDLATLAQYTTDNEAKHIYDIQQQLLRSIQFLKDKYETFKSYEYRVINAAIYYSARSKKYEESGIRTHASEEITALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MM48</accession>
    <name>A0A167MM48_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_168602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291289.1">
        <property type="nucleotide sequence ID" value="XM_018435901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MM48"/>
    <dbReference type="GeneID" id="28996807"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168602"/>
    <dbReference type="InParanoid" id="A0A167MM48"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007890406" evidence="1">
        <location>
            <begin position="20"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="151" mass="17218" checksum="1073DF17E7E3E4C1" modified="2016-07-06" version="1">MHKFILLLLLLISFEMTIALPNLPFLEARGVDLATTPACNGCLDRCKKSSDPYCSADCCWVCIPGRGGYQTDYIILVRRAPYSHYFVFFQDFIKTADKSASILTVLFNRQKTNPSSIHVRTFVISQKIIYYKPQNINTKRTVLKSHNTTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MP88</accession>
    <name>A0A167MP88_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_158935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291469.1">
        <property type="nucleotide sequence ID" value="XM_018433880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MP88"/>
    <dbReference type="GeneID" id="28994786"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_158935"/>
    <dbReference type="InParanoid" id="A0A167MP88"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="120" mass="13778" checksum="A40DF0301B61EBAD" modified="2016-07-06" version="1" fragment="single">DQRSLLQLAHLHGHKHIVRYLLRDTNKDLKPQIKHGNKDDINHDYLEDWPLSGYCLTNQESPVLAQSNQGCPDETFEPKPSVHPCQLIHDDACPLQELICWPEHISLDALERSLACQIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MSS9</accession>
    <name>A0A167MSS9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Gpg2</name>
        <name evidence="12" type="ORF">PHYBLDRAFT_20455</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">G proteins are composed of 3 units, alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G protein gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291864.1">
        <property type="nucleotide sequence ID" value="XM_018439735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MSS9"/>
    <dbReference type="STRING" id="763407.A0A167MSS9"/>
    <dbReference type="GeneID" id="29000641"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_20455"/>
    <dbReference type="InParanoid" id="A0A167MSS9"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000003">
        <property type="entry name" value="G-protein complex gamma subunit Ste18/GpgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041848">
        <property type="entry name" value="Ste18_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50058">
        <property type="entry name" value="G_PROTEIN_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="11">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD73824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="80" mass="8752" checksum="FE6DE214AA1F80F1" modified="2016-07-06" version="1">MTTRRAQNISEAKLNRLLELNQCLREQLDVPRITVSSASSSLIEYCKNTKDPMVPSVWGPIDKKEDPFAPAAGGGCCAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MTB9</accession>
    <name>A0A167MTB9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHYBLDRAFT_112298</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291929.1">
        <property type="nucleotide sequence ID" value="XM_018428269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MTB9"/>
    <dbReference type="FunCoup" id="A0A167MTB9">
        <property type="interactions" value="376"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167MTB9"/>
    <dbReference type="GeneID" id="28989175"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_112298"/>
    <dbReference type="InParanoid" id="A0A167MTB9"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13279">
        <property type="entry name" value="PH_Cla4_Ste20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000139">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000705">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="3"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="14">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="327"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="174"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAD73889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="599" mass="68062" checksum="4C2878D3E8B06CF0" modified="2016-07-06" version="1">MTEIIKDGYISVKEDGLRAWIWSKRFSVLRDQALTFHRNEQSGQCVALIFLKDVNSVTRTDLKPYCFEIGTKEKTYYIACKSDEDLYSWMDEIYNRSSVGSSGPTNFVHEVHVGFDPVTGAFSGLPDQWTRLLKGSAITAEDAAKNPQAVLDVLEFYTEQTKREADEYGSSQLMGAPTQQHIPSRPAPSPPTQGRRPDLYDSMNDLSISKNRDQIPTSPIRQQYSKPMYPRPEPSKSQGTMHSHRIPKHSSSATTYEDRVQYEREREQEMREREREREREIREIQKAAAQVSAPKKKVEQRISTMTEAQIMEKMRAVVSPNDPNELYKRMKRVGQGASGSVYLAISLSTNSKVAIKQMDLAHQPRKELIVNEILVMKESQHPNIVNFLDSFLVKNMELWVVMEYMEGGALTDVIDHNTMTEQQIATVCSETTAGLHHLHSQNIIHRDIKSDNILLNAYGQVKISDFGFCAKLTDQKNKRATMVGTPYWMAPEVVKQKEYGAKVDLWSLGIMAIEMIENEPPYLDEEPLKALYLIATNGTPTLKNPEKLSRELKGFLAVCLCVDVRSRATAAELLEHDFLKKAGPLEILAPLLKFKTTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N3X8</accession>
    <name>A0A167N3X8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_158536</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292949.1">
        <property type="nucleotide sequence ID" value="XM_018433809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N3X8"/>
    <dbReference type="STRING" id="763407.A0A167N3X8"/>
    <dbReference type="GeneID" id="28994715"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_158536"/>
    <dbReference type="InParanoid" id="A0A167N3X8"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000382">
        <property type="entry name" value="G-patch domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040052">
        <property type="entry name" value="RBM17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288:SF8">
        <property type="entry name" value="SPLICING FACTOR 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288">
        <property type="entry name" value="SPLICING FACTOR 45 SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031066">
        <property type="entry name" value="Splicing_factor_SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="G-patch" evidence="10">
        <location>
            <begin position="30"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="91"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR031066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD74909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21770" checksum="8BF0EBD06F6E6E94" modified="2016-07-06" version="1">MRRARLSQRPPTQADEEPVSGPSGPGLGSGEDMARKMLAKYGWQEGQGLGRSEDGIREALRVQATGRGGGMIINSQPEPKTQTPLHKRQSQVILLTNMVGPGEVDDMLQEETADECAKYGKVERCLIFEVPNGQIADDQAVRIFIKFVQVEAAQRAINDLDGRYFGGRVVSARFYENDRFDRLDLAPTSEEYARNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NA04</accession>
    <name>A0A167NA04_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_64367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293490.1">
        <property type="nucleotide sequence ID" value="XM_018441286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NA04"/>
    <dbReference type="GeneID" id="29002192"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64367"/>
    <dbReference type="InParanoid" id="A0A167NA04"/>
    <dbReference type="OrthoDB" id="2267106at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="118" mass="13083" checksum="0CDBA33F6A2C2ABD" modified="2016-07-06" version="1">MTQSPCNSAEAKVENKTILNEALPSEVSESMQAMAAVMSMSDADCEDGSPEDDDSETGDYWSEDDYEVIKAYYENEEDDEDETLLVLNDQAQIMPSYARGTKSTAIPQDIIKNPKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NBY6</accession>
    <name>A0A167NBY6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_77756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293668.1">
        <property type="nucleotide sequence ID" value="XM_018443293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NBY6"/>
    <dbReference type="GeneID" id="29004198"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_77756"/>
    <dbReference type="InParanoid" id="A0A167NBY6"/>
    <dbReference type="OrthoDB" id="2221454at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF72">
        <property type="entry name" value="IM:7136021-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD75628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="679" mass="76982" checksum="15DB6328D9C14A00" modified="2016-07-06" version="1">MLASEVPFEILTKIANLLQPSELRTCTVVCKSWHDSFNEVIWREVTIETDIQLEKLCDISTAEENPYQDNGHLVRILALDQKLVMTVEKLNAIRSQFPHLQSLSIELSRNLFPRDIPAVFDVWPSLTQLHISPSRIAASDGVKEFLKFMTFFPNLRVLFCTEFSPFRTRPFNLIDIETLHDILPQLEVLRIGSVFAPLSSEDVLSLEKVVPARKLVKLRVGFLNLDSRWLCYYVHKYPNLRGFTLYNHGGMHRKSSYEEARAMFPKLSNCFPYLETLNLTGFSPTAWSHIALADLIFGFNNSIKHFSTYLRTNVEDPGIQQAVKSCMRVFPATIVSLRITSEFNFTDLEALPTALGACHHLKYLYMGAKDVSVQLDTILDNSPALKMLTLKQVNISLSPGVPEAPALHGLRLLYIDADETDTGQIDTELFSYISVRCRQLRYMSLHGAQITCSNVLSTDNLCFSMPHTNLKYLQLENISYQLPKMHSGQESRNMVIFIQKDAPLESGNSGADYLFIKSSLMPIAKSTWLQMYFDRKTQNSLVKLRVLTEGEAEIAERYSNSTELDNILCSSSSDESAVFLSPLEATTQNLLSRGFVSFIFGSVERYDFCMDSDSNKKKWYDHPDESFNQLPSQSCVLLFLICNVWIPSATAILAVSMSLRKLLFMTAPSVSGHVFFRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NEV9</accession>
    <name>A0A167NEV9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_163539</name>
        <name evidence="2" type="ORF">PHYBLDRAFT_166964</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293778.1">
        <property type="nucleotide sequence ID" value="XM_018435547.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296468.1">
        <property type="nucleotide sequence ID" value="XM_018434818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NEV9"/>
    <dbReference type="GeneID" id="28995724"/>
    <dbReference type="GeneID" id="28996453"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_163539"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166964"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD78428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="742" mass="84641" checksum="99ED869E6C83646A" modified="2016-07-06" version="1">MSTIPELYNEKCHCAGCSQNDLGYSFVARRTAQRHNKRARLNAIRCERDMSTQRNMMEVDDEPILTHQPGTLKESYTQTNSPVWEGASMSDTEDVSVTNDAISNGDNDDSGSNSNEISEDESEDDVIELDDNELNSEDPFATPDMPQNPVHRFIATFVVMFASHYVVDKGAVVLIEFINKLLTIYQQDFQLPLSLPGLQRMTGFSAMTKGIKKFVVCQDCHKVYEESASVPSHCDFVKLGARSSCNCQLMKTSASGALVAKRSYLYQSILHRLGYLDLVRGTIIDPMHNLFLGTPKRLMDRWIKDEDIQDGDFAAMQKTAETMIVPGGYTSLNSKIGKQFSYMKADEWKSWVLIYSPVLLKDVLAKDRFENWINFVDACRLLIKPTITFDEVNTAHQFLQTFCTRCDELYNAEILTCNMHLHLHLRDTIRDFGPVYGYWLFGFERFNGLLKNLKTNRKIGFEETFMKKFIEDVHKDDLVNSFLQSTCQTSAFPLLTKLTSSFTPATIPSIRQRTFRIQSFVEASEDPNVLVKGNEPLPPSAFPLSLKSATTMSDIHYVHLLQYYKVAYNNEQLVHFQQASESSYFVDNTITLLKYINILGQVYKGKGESGSRGSLVQAKFIGSTGEHIIAYTGQIQYIFTHSFTPPPTSSSLTPLLRTHRRPTQLLHNSQHTFAFIKWYTPENDKSREYEHVETCFPTFSPDDFQCVLPVHRIMLEVATAEHTTRRKVKKMLVIPLPKKQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NI36</accession>
    <name>A0A167NI36_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_59485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293998.1">
        <property type="nucleotide sequence ID" value="XM_018440504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NI36"/>
    <dbReference type="GeneID" id="29001410"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_59485"/>
    <dbReference type="InParanoid" id="A0A167NI36"/>
    <dbReference type="OrthoDB" id="2289141at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026960">
        <property type="entry name" value="RVT-Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13966">
        <property type="entry name" value="zf-RVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase zinc-binding" evidence="1">
        <location>
            <begin position="176"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="248" mass="28324" checksum="16B34A7066E5F008" modified="2016-07-06" version="1">MPVPLVGYVPYDKFVYSMFSKTARRSRLCIPALRTRNGALSTLMGAIHSIPRDFSLLTLSCTACLSLKLLDAITYTASSAPVTSSWRRLNASDAFIFDQGLQAIHSKTQTEWSTSPYLIAKLFWDLANATAELTHFFWRATLPLNDHPELLLPVNPLVSCRDHTQSPLVPLPLQGKQWRLFWAFPIYHTSRNIWYWAIRNSLSCQYNLHSRAPTIFVTPNCPICLSEVDTLSHFLYQCPQKWTVWETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NJS9</accession>
    <name>A0A167NJS9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Apses-type HTH transcription regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_166066</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFG1/PHD1/stuA family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294134.1">
        <property type="nucleotide sequence ID" value="XM_018435359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NJS9"/>
    <dbReference type="STRING" id="763407.A0A167NJS9"/>
    <dbReference type="GeneID" id="28996265"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166066"/>
    <dbReference type="InParanoid" id="A0A167NJS9"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029790">
        <property type="entry name" value="EFG1/Phd1/StuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792:SF1">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="6">
        <location>
            <begin position="192"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="67"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD76094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="482" mass="53148" checksum="1D97B000F18A2E07" modified="2016-07-06" version="1">MYQSMGQATPYSSLSDIYPNQYNSPVMSPSSAPITGSPLGCEPYSTHQSSLGSPSPTHTPTQINAQTTRPNSTSTSSPISTSTSSPSPSHNSHQPTNNTTTTTNTHYSTPTSTSTGTSTATATSTPTPTHTSTYTPASYLSSHWSSPGLSWSASPPLPVTSYQPNRPYYSNLNSSCFSSTTSLTGLPIQRPKLTTTVWEDESTVCYQVDTQNVCVARRQDNDMINGTKLLNVVGMSRGKRDGILKNEKGRVVVKVGAMHLKGVCLIIIQNKKEKHPNKSNRITFSRARYLAMKFKIYDLLFPLFTDDPSAYLLVSLDHPANKNLHTAKGTKTTCESICAPSWDTSHTTGLPRLSQSEGKHSLLYIYLCVLSLPHPFTYSPVPGLLSSHFLQDTPMYMQCERTLQRTSFSESEDYKYKYSVGGSQNESSLYHLPKSLHTLQLTDLPSTFGMEQTLGKHKQKDLESAFQIHLPEKKVKKYIKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NLU8</accession>
    <name>A0A167NLU8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_166203</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294269.1">
        <property type="nucleotide sequence ID" value="XM_018435378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NLU8"/>
    <dbReference type="FunCoup" id="A0A167NLU8">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167NLU8"/>
    <dbReference type="GeneID" id="28996284"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166203"/>
    <dbReference type="InParanoid" id="A0A167NLU8"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="253"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="210"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD76229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="532" mass="59503" checksum="B84CB4A8C17F1340" modified="2016-07-06" version="1">MSLYVQDGPSNEALKRNSAALDITSMLNPELAINIDHLNKKPCLDPGLTRPKSDTAGNSKRLPLRKRLSKESQNCPVLKWQPVETPNRTPTTTTAAGAGGGGIGVGLGGTMTMNTPTTVDQRLSRPSSRPSETWETIEESPEPVIDRHTPDTTTTTTTKTVVTSTTSAAATMKKPLKKVQHWITKGKTSSPEIPQDTTALVWKYENGVDRETRTAPAEPLLKEEPKVEQTNKPVSKSLPDQTLSRSGPAADDTLYCFCRTPYDAPRFMIACDLCDQWFHGECIGISEKQSEFIGHYFCHSCAKREGKKTSWKAHCANPVCQRAARMGTKGQMSKYCSDACGMQVARTRIACAESKRRSSVTSSSSSSSSSLADRHSYLTKSRLSSFADRDDGHRLLRVRDEKKRARRMIGIVERKTAFLATLSTQPTADEDVCGYDCRLSWPESKWEAEELPSLDPEMACRQSRRCVKHNGWQKLKTLELEQERTEQFTVLAMLERERQQIKARMKRRREDVDLEEMLANGTICHQRQTTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P9Z4</accession>
    <name>A0A167P9Z4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_157782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295588.1">
        <property type="nucleotide sequence ID" value="XM_018433678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P9Z4"/>
    <dbReference type="STRING" id="763407.A0A167P9Z4"/>
    <dbReference type="GeneID" id="28994584"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157782"/>
    <dbReference type="InParanoid" id="A0A167P9Z4"/>
    <dbReference type="OrthoDB" id="608866at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41733:SF1">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_30, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41733">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED/TRANSLATION ELONGATION FACTOR EF1B, N-TERMINAL, EUKARYOTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="26"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD77548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="262" mass="29619" checksum="5F54B73665496EBF" modified="2016-07-06" version="1">MTAGARNVLRSNDSASLWNCTLSPGWTEEESELLRSALMKFGIGNWAKIIESGCLPGKTNAQMNLQLQRLLGQQSTAEFAGLHINPKVVGEKNSKIQGPHIKRKNNCIVNTGGKLTREELRERLLKNKKLYELPESEWSDIELPKMEDPMLLLESKKAEMQRLNDELEKVQQKIQKMREAHPGRMEKLKSEVSRSPSPATPSADEDDELMPTIISTEDDLAIALALQNEDDSPILEAEDEEAEDEEFVPKRRRLGKSKKNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PBL8</accession>
    <name>A0A167PBL8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_122484</name>
        <name evidence="6" type="ORF">PHYBLDRAFT_128685</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441005">
        <property type="protein sequence ID" value="OAD66135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284175.1">
        <property type="nucleotide sequence ID" value="XM_018429232.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295649.1">
        <property type="nucleotide sequence ID" value="XM_018428873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PBL8"/>
    <dbReference type="FunCoup" id="A0A167PBL8">
        <property type="interactions" value="528"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167PBL8"/>
    <dbReference type="GeneID" id="28989779"/>
    <dbReference type="GeneID" id="28990138"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_122484"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_128685"/>
    <dbReference type="OrthoDB" id="1294322at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002190">
        <property type="entry name" value="Ribosomal_L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="5">
        <location>
            <begin position="5"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD66135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD77609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="175" mass="20799" checksum="748B23790C189CB9" modified="2016-07-06" version="1">MARFHEYQVVGRKLPSAKEVAPKLFRMRIFAPNTVVAKSRFWYFLKKLRKVKKAAGEIVSVNEISEKRPEQIKNFGIWLRYDSRSGTHNMYKEYREMSRCEAVETCYQDMAARHRARFRSVQIIRVAEVKNADVRRQYIKQLLTPKLAFPLPHRVQRAEKGNRSLYLAKRPSTFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PCM2</accession>
    <name>A0A167PCM2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_60797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295709.1">
        <property type="nucleotide sequence ID" value="XM_018440699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PCM2"/>
    <dbReference type="GeneID" id="29001605"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_60797"/>
    <dbReference type="InParanoid" id="A0A167PCM2"/>
    <dbReference type="OrthoDB" id="10624405at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD77669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="251" mass="29066" checksum="A8A2EE34DAC07953" modified="2016-07-06" version="1">MKRATSSESNNPTKKQTVHRGRWNYKRELTLMLAYNKYHSYSQPHYNTTAAWQNIIVAVNAVKSDDLNPLNETLMDLPQDERHLQATPMLKTALGRATYQAMREEDAYKDRKMLDEKRGLAKKKSDKRRGDELMHMALYGTKGSKTDSTTKTSSEQHGDTVENEDVDEDYDEDEEDEDEGSVTASNYGNDGHFDTPMNKKVLNILEMQELLLDKQELFMEKQETFNCKFALLLQQLVEKHCVYVDRTDKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PKP1</accession>
    <name>A0A167PKP1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_73588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD78129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296169.1">
        <property type="nucleotide sequence ID" value="XM_018442884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PKP1"/>
    <dbReference type="STRING" id="763407.A0A167PKP1"/>
    <dbReference type="GeneID" id="29003790"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73588"/>
    <dbReference type="InParanoid" id="A0A167PKP1"/>
    <dbReference type="OrthoDB" id="2416077at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="180" mass="20955" checksum="64980B6BF6B8A480" modified="2016-07-06" version="1">MQDANSSENTHGSYEKANPYKYRCIMYMYLANYGATQISLVVGMSLSTVKYIVKRVDKTGSPESRKGSRQPRKIDERTERHLVQIVCKDPFASFSRLRASLKNMESCFWASGFGPLVFLDGNANQDQYVNTLAQNFLPWFQNLSWEQNRSFVFQEDNASCHTGLYLRWWKDSHEIRGFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PQC9</accession>
    <name>A0A167PQC9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_69697</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296394.1">
        <property type="nucleotide sequence ID" value="XM_018442151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PQC9"/>
    <dbReference type="FunCoup" id="A0A167PQC9">
        <property type="interactions" value="775"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167PQC9"/>
    <dbReference type="GeneID" id="29003057"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_69697"/>
    <dbReference type="InParanoid" id="A0A167PQC9"/>
    <dbReference type="OrthoDB" id="10265467at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18139">
        <property type="entry name" value="HLD_clamp_RarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000001">
        <property type="entry name" value="Putative AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3710.10:FF:000004">
        <property type="entry name" value="Putative ATPase, AAA family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000137">
        <property type="entry name" value="Replication-associated recombination protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3710.10">
        <property type="entry name" value="DNA polymerase III clamp loader subunits, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051314">
        <property type="entry name" value="AAA_ATPase_RarA/MGS1/WRNIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779:SF7">
        <property type="entry name" value="ATPASE WRNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779">
        <property type="entry name" value="WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="33"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD78354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="407" mass="45323" checksum="87C10C20A8A5BE8D" modified="2016-07-06" version="1">MSKVRPTTLSEFVGQEELLGDLGILRTLMQQDQVPSMILWGPPGCGKTTVARIVSKMTKSRFIEMSATSNGTADAKKAFDDAKNYMKLMGGKTIVFVDEIHRFTKAQQDVFLPAVEQGTIRLIGATTENPSFKVNSALLSRCRVFVLKQLTEDQLLEILKRAVKSWRDKGNKENPIQISPKDRQAEEKALRTLASNSDGDARNALNTLEIALSVLPSKGSLLSSDTVKDAFQKSHLLYDRNGEEHYNIISALHKSIRGSDANAALYWLGRMLEGGEDPLYVARRLVRCASEDIGLADNTALPLAVAAYQACERIGMPECDTILAHLVTYLAETKKSVRTYKAYNKVKQTIREEPNHPVPLHIRNAPTKLMEDVGYGKGYKYNPDYEGPVDQTYLPDALIGREFLEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PRH3</accession>
    <name>A0A167PRH3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">U3 small nucleolar RNA-associated protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_179550</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296447.1">
        <property type="nucleotide sequence ID" value="XM_018438165.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A167PRH3">
        <property type="interactions" value="716"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167PRH3"/>
    <dbReference type="GeneID" id="28999071"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179550"/>
    <dbReference type="InParanoid" id="A0A167PRH3"/>
    <dbReference type="OrthoDB" id="31183at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012954">
        <property type="entry name" value="BP28_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056473">
        <property type="entry name" value="HEAT_Utp10/HEAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022125">
        <property type="entry name" value="U3snoRNP10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08146">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23243">
        <property type="entry name" value="HEAT_HEATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12397">
        <property type="entry name" value="U3snoRNP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01036">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BP28 C-terminal" evidence="9">
        <location>
            <begin position="1823"/>
            <end position="1976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD78407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="2112" mass="237291" checksum="3BD44EF69545AA7C" modified="2016-07-06" version="1">MSTLQQQLKKIGTADLRNVSEVSRKFKASFLFTAREAADQDLDTIYSIAYNGIMELTILDSKFAAYESTLFSEEMKSVDRILQSEEENAKLNASIKSFLQNLSPYFLLKPAGKVLEYLIRRFRINEFNVEDILICIFPYHETKAFVKMVTILNIEQNSPWTFLTPIQKTGIPLERSLLVARMARKRNILNFVTDLVIKSPVHFPTLYSFYAATMIELVSERVINEDSVMVITGNLIDGMNTSDVPELQIASYMILSQLATKVSMTKEAVHALTDAAIKHYNKSYFNYCLLTVVHLAQSQTSCVRLGKSATKRLLKASAFDKTLLEIAEKYAIDRFFTVIVGALCDASKVDLLVEIVLQGLISSDNIRLLCENTIEGYLNLVESGCTEETKESYTKQFQPLLATVSQRYVDELDTVLEAKLNSYANKSDEKSKILYEFASIAFKGTRHEVIEEANTTLYLCLNSPAVTTRLLALKKLVDVMDNESSPLTQSPEVFQSAFTGCLNSIDETLVYAVRDVPEQLLKSVSSEVIISSISSLLRDNNVLARKEVVTIFKFLLGPFVAKYPNKTAKVAQLLATFIFAAPTDQVKLLEKESTASTKDAVLKSMLSSMKSASKKPASLSTLFVKLEADVIKSEKDDHSLLFWIQGIQSQNVSTRTLALLVLNRAVFVSADERQYKVASKCLSAITESLTEEQCHDLYTVKLASASAIISSEGLPVESFVEQLKKNSVTSILQINLVQSTLDNITVSLKHATQVSWFSEKKPQATESYCHTVTELFKVFANGATLGSFEEMITKLVSIQLKDNVLSFLMNVWSYNDNAFLVKARALQIAATYISQVAPKNTIDFQHVLPVLLPCLTQEYLAIRINALRCLESIQSTYKSIGLPTGKKVYSSDDSADANTKATGKAVVESAKSLYDITVSFPDLRTNDAAHFVDYLSYRKEEIKQDQKYTILMLKDYVRICDESKEKQQKVRKNHIIDFLLNHVMHAPLADIQINILSVLNEVETPRKLQQLYPLLETVLDSPRTTKSTTLVALLIHCYSPLNAADFGSKNDKTLALFLRLLSNRDALEGEDEDGWQASTRRFALKQISSEFFAKANEKAQKSILSLLMDIATNGQQSDVRAAKTVLAEIPIAAKMLEEMLFVVAKSISSSTSETETSTLTTKRARTAEKPAEKKSVDLYELVTVLELIESKTIENDVALIKPLFEVLTAMVNADLRDSPVSLEYINQIIMSSLTRIIQSAEEKKVHVDESTLRVDVVVQCIRVTGNPQTHNQALLLMATIASMYPECVLHNIMPVFTFMGANVLRQDDNYSFQVIQQTLEKIIPPLVASSRLSSNNEAALALQVKPIIKVFVDAMFHIPKHRRLRLFSVLIQTLGEDEFLYAIISLLLEKFTEKLAKGARTEADSLTEFSLTISQQFSPQTQMKAVLSLLNGLLVLPNDKSEDEVMNQDTLFNTNEHNAKQLRQYKLATLNFVGQLLGSRSFLGKLMAQANLSEEFEKEMQPYYLTAVEYILKIVTYFTGFRDGYAVSQNANPSITKFWRGMLKVVYDDLAKVNALLPLPAFVDVVSHLIKHSEVSIRRKAMDMFNEKLQVFNQITEEDEVLLVGMVKQFTDVIEKESALSGEEDCLVNKQSALLCISSLASLFGAIFPEQFSEAIPVVIGKDCLLLSKPQVKISSLVCLTVICQEIGPRAMPHLPKFMPIVIDILSMTVEAERPNAMLQLSVISALETIVKVLPHFISPYLSKILANLLHPSIYTSDETNATQKLLAKEKVMSVLVEIATNVPARTLFGPVFTSYPLAVKNGKESVLALLKLASEAIRAVSRDAMTAHYKQLFKFFLTAFDIRRIHNDIFDDEAINEIESAVISAFLDLVMKLNETLFKPLFLKVVDWATVELAVDGSTESVDAKKRVLFFYKLLDSLLDKLKSIFTPYFGYVIDDVIDRLDAYRSEEKQEEPDTLWNFIMSALHKSFLYDNDNLWNAEKFEKILDPVVDQMLVTAKGDAPDYLTRMTTYLVPLVGQMAVTVSNDTLWKPLNHKILMKTREDIPEIRLAALRCIEEFYSRLGEEWLLFLAESISFLAELMEDDDVRVEKLVQLVNAQIETHLGESLDKFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PXT5</accession>
    <name>A0A167PXT5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_107970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296777.1">
        <property type="nucleotide sequence ID" value="XM_018428024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PXT5"/>
    <dbReference type="FunCoup" id="A0A167PXT5">
        <property type="interactions" value="488"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167PXT5"/>
    <dbReference type="GeneID" id="28988930"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_107970"/>
    <dbReference type="InParanoid" id="A0A167PXT5"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000002">
        <property type="entry name" value="10 kDa chaperonin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD78737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="95" mass="10352" checksum="4E49ED031F82DBAA" modified="2016-07-06" version="1" fragment="single">KNIVPLLDRVLVQRIKAQEKTAAGIFIPEKAQETLNQGHVVAVGKGALNKEGAHIPLQVSVGDKIILPPYGGSVVKIQDEEFLLFRDSEILAKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q4A2</accession>
    <name>A0A167Q4A2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_141102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD79048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297088.1">
        <property type="nucleotide sequence ID" value="XM_018430527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q4A2"/>
    <dbReference type="GeneID" id="28991433"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141102"/>
    <dbReference type="InParanoid" id="A0A167Q4A2"/>
    <dbReference type="OrthoDB" id="2275798at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007891398" evidence="1">
        <location>
            <begin position="19"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="244" mass="27600" checksum="D4B4A50EED73B8F5" modified="2016-07-06" version="1">MSSLTNCYWLVTVSTILATESQISEISSQTTDFTVLRLMFSETLFMFSAFSAGSSTHISLEDKDLLSLVDDNITEAGDNIFTKNIFTTSQLLSIKLYDVVTSFNISTECYGQLINLMNMVFQDHDKLSKDIVGPVNALLKKKTAIKAHTYDICENVCDASTPFVSVKTMKMMSLSNQLARLLGNNNIREKLHYRANRQLISNKLSNYFDREEYRVLKAQHFFQSSNNIAVALFLDSFGNQKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q6A7</accession>
    <name>A0A167Q6A7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="10">p53-like transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_184664</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Su(H) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297187.1">
        <property type="nucleotide sequence ID" value="XM_018438969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q6A7"/>
    <dbReference type="STRING" id="763407.A0A167Q6A7"/>
    <dbReference type="GeneID" id="28999875"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_184664"/>
    <dbReference type="InParanoid" id="A0A167Q6A7"/>
    <dbReference type="OrthoDB" id="5600360at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1450">
        <property type="entry name" value="LAG1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015350">
        <property type="entry name" value="Beta-trefoil_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036358">
        <property type="entry name" value="BTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040159">
        <property type="entry name" value="CLS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015351">
        <property type="entry name" value="RBP-J/Cbf11/Cbf12_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037095">
        <property type="entry name" value="RBP-J/Cbf11_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10665">
        <property type="entry name" value="RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09270">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09271">
        <property type="entry name" value="LAG1-DNAbind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01268">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01267">
        <property type="entry name" value="LAG1_DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110217">
        <property type="entry name" value="DNA-binding protein LAG-1 (CSL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RBP-J/Cbf11/Cbf12 DNA binding" evidence="8">
        <location>
            <begin position="123"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-trefoil DNA-binding" evidence="9">
        <location>
            <begin position="271"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="432"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD79147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="621" mass="68156" checksum="3375EFEECB49B332" modified="2016-07-06" version="1">MNSSTHVLSEEVFGSSKKIQFVQTTSSMDSLLSAVDRAPRINLPYTQSKQTMSIEALLDTNGHISKSSAKRSWTYDITDRSPKTKIHRSQLETHSPPTEHCPEPIQHLSLSSSLLLPPQRLSTITCLHAAVAQKSYGSEKRFLCPPPVVTLKSTTPGLRTDSPIVSMSVVCESIDRPVEQRASLDDNQSGSFKYLHVTGTAKAKQFCLRVGLSHSHSHSHSQFPPLGSSSPQQQQNQHHQISQPFATFFSSPVSIISKPSKKTAKARNVSTCILANSPVSLFNRINSQTVRTKYMSSDANRLCAKSSAWSAFNIQIIRQPEDAEDNEDGPVPVLYGTEIILKDTQSGVCSPPLIVRKVDKGCIAATATGPISQMQKIALQLKSSVNIEVVDDYLCWTIVSIAKFEYTFADPIMVGMDVSPCSKMAESRLVPSSASSSSYSSPSHSPSPSSLTCRHAQPSPPPSPPRTIVPYPSLSSVSYNHTLHAIDVVGHHLFQKSTMPPRLLEFWLGNHGPLKQVPHETSLVRVELPPTQDLLVANHNILQRQANGERHLELALVLVRQDGMVYPTGKSLSCAVSVNGDTSRCLYLHFAYIILAHKAHMNVRTNRDKGAYLNMIDKPHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q7G9</accession>
    <name>A0A167Q7G9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_58264</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297256.1">
        <property type="nucleotide sequence ID" value="XM_018440288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q7G9"/>
    <dbReference type="STRING" id="763407.A0A167Q7G9"/>
    <dbReference type="GeneID" id="29001194"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_58264"/>
    <dbReference type="InParanoid" id="A0A167Q7G9"/>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="6">
        <location>
            <begin position="211"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="100"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD79216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="385" mass="43123" checksum="11942067A534AD38" modified="2016-07-06" version="1">MKAQKLPLYRSVTEDKSPTENHSHFTRFVSKLLGLVRVPKRPRLEHKSHSTTSITKSSVISFQPRHYNQPSNSDALKAQICSDPTTLVSVVNCDTSLITTRTTDDSSSLSSQTTDSIQSTGDDDDDDNEEEEEEEDLKSITSINTSTSTNISIPRSTSCPQTRRKPFSAAIGALVSASKLPTKPPPQRLVHFDSFDMPPPTLVDRRPDTEPVMTSEIAEQLRPYLPRRYRLAPQWSLLYSLDQHGISLTTLYRLVKSNKGPCIITIKDADDQIFGAFLNETLTCGTSYYGTGECFLWKTTRQDSTQTAHISPKIKVFPWTGKNEYMILSENDFIAIGGGDGKFGLWLNADLEKGHSEQCPTFDNECLSPSPEFECIELEIWGFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q8G7</accession>
    <name>A0A167Q8G7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_58317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297307.1">
        <property type="nucleotide sequence ID" value="XM_018440295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q8G7"/>
    <dbReference type="GeneID" id="29001201"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_58317"/>
    <dbReference type="InParanoid" id="A0A167Q8G7"/>
    <dbReference type="OrthoDB" id="2285227at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF5">
        <property type="entry name" value="F-BOX AND LEUCINE-RICH REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="663"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1268" mass="146826" checksum="99C778B4E914E479" modified="2016-07-06" version="1">MLASELPFEILSHIASFIAPDKNFDYTVVCRAWKIPFQESMWSRMNIYTRKKLEDACNTPASNQSYYKIHGHLVRELTLSKRLQTSDRQLRILQDLFPSLRSLYIYEESVDNIEFGVMADWSIWRSLTHLKICVEGFEIEVNVKKFLELLSFLPCLKRLEYVKALCGLSSLFKIDDFETLHRHLPQLTYLSTAMDLDNISPNDIQTITNSNPASPLTTAEIRVDHMDIRWLWYFAQKYPNIRTLEWKIINTGFDTSVSPDEVISLFPSLTFAFPHLNKVVMKGESEKVSMHLAFWDLVYQFRAPIKHLVYYLAGRRNIPELLEQIIKKCMSSCSETLETLLLLCWAEMCDPLIIPNALGICTHLQSLNLEVRRSSIALDVILDNCSLLKKLKLTSQRVSIQPDASNSPKLHGLRFLELRMATIKSTLFQYISSRCRSLNYMRLASINIFGPLLPKTGSLNLDMPHTCFERLELNCVVFCASHDDWSIEMPINFMALSQTNSTPCDKNTPSQLVWFHLHRPSRCGHQRDQIRILKKAEAKYSRKYFRAFERKTVKNPDSQNGVRRSYHGQVLKHLWKKDLPLGYARLNCKYSRNFVVDTKESQKRNKFLNHHFCFNVCFSRCVPIYLDLITITHSFCGLSSHEADILKTLSTNCEKIFVISIFIMSASTLPFEILVHIASFLSTNDKLTCILTCKAWEPAFQETLWNTVDIRHKGKLNVIHGVLVSKGDSVHSQGTYVRVLVFALGLKVSSEQLRTFQRHCQKIQHLIIREGGLSKDYFLKKPDWELWGALTRLEICLSGLNLVNEPRELIYIISHLPRLRRLDYVDAMMGPRPLYKLQDFEALHNHLPQLEYLSMAVWLDVVPTEDLTIIKGATPANALTTLKLYVDNMDLWWMYYMAQKYSNIITLEMKIDTELRRPNSFREDETSKLLDLSDVFPRLENTLIACRPNTEWSQLTLWDLFRRFDTPLKNLKYDLHSCYDMSGSLERTVSGSIQSCSRTLESFHISSYVDFSDRCKVPRALSFCPNLVDLQITSYITIVALDIFLDHCAVLKNLTLSVSMLSVIASPFHDSTPHGLESLKISRATTNGCILRYTSLRCKNLKYMYLIDVNFFGIINQETGSLCIDMCDTRFKYLELVRVSFYSSSGDRENSLKFLCISWPNYSLISDTMLQGNNDSSLWFHMYSSLADTGPHNNGLMVLSEEEIRLSEKYFSNFRLNSANVFGNQEEDRFYRVKSTWNNWIDWRKSLSLGYATIRCASVEKYHITYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QDP6</accession>
    <name>A0A167QDP6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_100837</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297587.1">
        <property type="nucleotide sequence ID" value="XM_018427606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QDP6"/>
    <dbReference type="FunCoup" id="A0A167QDP6">
        <property type="interactions" value="349"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QDP6"/>
    <dbReference type="GeneID" id="28988512"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_100837"/>
    <dbReference type="InParanoid" id="A0A167QDP6"/>
    <dbReference type="OrthoDB" id="3265906at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="5">
        <location>
            <begin position="73"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD79547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="244" mass="27266" checksum="D660219F5DD1C847" modified="2016-07-06" version="1" fragment="single">AVQRATFATHPTFSTVDAAEVQKFSDKSAEWWDPEGEFSMLQLLNPPRVAYVRDQLNTNPARPSKPFEGLRMLDIGCGGGLLSESLCRLGGTVVGADASGDNIKMAKLHSRKDPMLWKGPGKLDYRHTTAEDLLAAEESFDVVLAMEIIEHVNQPLDFLRTCAQLTRPDGRLFLSTMGRTPIAYGLTVLLAEDILGLVHKGTHDWSKYIKSKELIDAVHSFGQEWVVESVRGIRWDPILRKWHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QF96</accession>
    <name>A0A167QF96_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_139641</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297650.1">
        <property type="nucleotide sequence ID" value="XM_018430261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QF96"/>
    <dbReference type="STRING" id="763407.A0A167QF96"/>
    <dbReference type="GeneID" id="28991167"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139641"/>
    <dbReference type="InParanoid" id="A0A167QF96"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF132">
        <property type="entry name" value="POLYAMINE TRANSPORTER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="87"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD79610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="593" mass="64422" checksum="32AD6602FC7272C0" modified="2016-07-06" version="1">MHENSTDNLHNPVSAAINDHTSSPSSMHSLELSQQTQNSLPVETTKKSIPKSSSLARLSAVAQKRVSLRPPVNNDPRLYSKGKKRWILACLALGSSLNGLCSTIYFPALPHITKDLHTNSVGMSLTTSLFILFGGIGPILWASMSDFYHIRRTLYLSSLIVFIVASVGCGLSGNVWVLVVLRCIQSVGTSVTNSVGAGTVSDCWEVTERGSAFSILFLGQFFGPLIGPIIGGGITTVLGWRATFWFCAAYGAFLFCFLFVFLPETYRVEQIWDAHLFHTPEPKNPQTEAKTSLTAVSGLSGISGQPDQSRLSRLSRLSISDESNEHTQVDSTRDLEAADNVDQTQNEINLPSSLRDHQSTAEKQSVQRLNPFQSITMLKHVFVLLVAIQTGVCFGTMFTVETIIPDLYESTYGLKSWQTGLSFVGAGVGNLIGSFVSGRLSDYLLKRARRQRGGKSKAEDRLTLNAWPGGFVLVPLGVLIFGWCIHAHLTIWASMIGFAIVCFGMSQVYASGSAYLVDALPGKGASVTAAANLLRMVMACILSLIAHPVVESIGPGYLATILASLNIIGMFCFVFVKLNGQKMRQKLTFGEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R1Y2</accession>
    <name>A0A167R1Y2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_74010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298698.1">
        <property type="nucleotide sequence ID" value="XM_018442962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R1Y2"/>
    <dbReference type="STRING" id="763407.A0A167R1Y2"/>
    <dbReference type="GeneID" id="29003868"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_74010"/>
    <dbReference type="InParanoid" id="A0A167R1Y2"/>
    <dbReference type="OrthoDB" id="2379842at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22744">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="58931" checksum="1D75012C5491FB7A" modified="2016-07-06" version="1">MKVSKRALLVIDQEVRLKCESSIVCECMNKLQYGLPCRHSLPAGRDIYISDIPERWVIDPRNVKPRDNTYRENFQLEERPEVWMEEVIKLESLFRSCEGSQQVANLLNKIKKVTSEFEGKTGHPSINFQAPEKIKYPGRRKGGARPKYLPKDFGRANWRKISVSSGHAGLKAMVRLRAKMREGKPAATQKTKNKKQNKNKQEPLDPVDATKNKIKQIKQEPLDPGCRLTRICFLVDATKNKTTKIKQEPLDPVDAPQKNGFKRPATALEDYQYDNRTSVGKRVKFQPGFPVSHEIIDDVKGGFSPTADGWCGFRVLAHLIYKDQNKFSLVKRDMLAALPKYKTLYTNTFGTDTSQLEKIIQHGSQLDYSNTSNTNTNFIPVCSDASMWFNTPDCAQLAADTYTRPVCVYSDNPNTPSTTFLPFALPNNKTKQRQPLIFNHVNSNHWTTVDLSRNISRKWPTVPELFFLGCARNKIDDNFDTYWNKFKEFNKHDRRNAMLSLHSDLDQPIDLTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N294</accession>
    <name>A0A162N294_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_151287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285798.1">
        <property type="nucleotide sequence ID" value="XM_018432652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N294"/>
    <dbReference type="STRING" id="763407.A0A162N294"/>
    <dbReference type="GeneID" id="28993558"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151287"/>
    <dbReference type="InParanoid" id="A0A162N294"/>
    <dbReference type="OrthoDB" id="3039677at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="382" mass="43646" checksum="573CD97E07B1629A" modified="2016-07-06" version="1">MASIRKPTVRKECQCSISHEDTCNTISSAVSEPVNQEEDSFEFEQEDVEINSELRNNVQYTSDTYEEEEEYEDKSNVEMDNDEGSVAGLKRLARFEALTSGVKKYIAYSKCHAIYDNEAAPLHCTLPNFGKTSLCGNYLFKSGPRSKAPKKTYVFHSVKKALKTFFQCPDFENKINSWNRSPKMYSTLFDIYNGAMWNEIVDVDVISFVDTKQSLMHMLNIDWFQPFDDVTYSCGAIYLAINNIPHSEQFKKENMILVRLMSGLKEASTSDINNYLKSFVDELMELYKGIKIKTHQCPNGTSIKAALLIVACDIPAARKVCGFTSHTSTNACHKSERQRLEVAHDVCWSKLHCLQYFDIVCCTIIDPMHNLFLGTTKRMLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N384</accession>
    <name>A0A162N384_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein 14 C-terminal Fig4-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_156822</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAC14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441028">
        <property type="protein sequence ID" value="OAD65414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283454.1">
        <property type="nucleotide sequence ID" value="XM_018433520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N384"/>
    <dbReference type="FunCoup" id="A0A162N384">
        <property type="interactions" value="676"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162N384"/>
    <dbReference type="GeneID" id="28994426"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_156822"/>
    <dbReference type="InParanoid" id="A0A162N384"/>
    <dbReference type="OrthoDB" id="5574975at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026825">
        <property type="entry name" value="Vac14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021841">
        <property type="entry name" value="VAC14_Fig4p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023:SF0">
        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023">
        <property type="entry name" value="TAX1 BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11916">
        <property type="entry name" value="Vac14_Fig4_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="5">
        <location>
            <begin position="88"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein 14 C-terminal Fig4-binding" evidence="7">
        <location>
            <begin position="622"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="810"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="854"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="881"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="922"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD65414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="958" mass="107216" checksum="004218DF0F96A950" modified="2016-07-06" version="1">MEPSIFSAALVKGLTDKIYDKRKSAALEIERLVKDNAKAPERIKQIVNELVQDFVYSNNPNARYGGLIGLAATAIALGPAIAQYLDIIVPPILSCFNNQDQKVRYYACESMYNIAKVAKGEVLRFFNSIFDALCKLSADSELTVKNGAELLDRLIKDIVAELSTTYVSPHQVPLNPAEEGQEALVIPSSLPRNTAFSLPRFIPLLSQRIYVLNSSSRNYLVSWISALDSIPDLELVSFLPEFLDGLIKCLSDPSNDIRVGVSALLTDFLDEIKQASTVREQQQQSEYRRTLEANRKKRQEEQRLKQKQKQEQSSRLEKQQHNDSVSEAKEGDEGDKEVKKEEKVEDHPVPSENDAVENDDDDNEATDVESDGHGKGSYVPGQGVIVQYGKIIEILLPHLSSEEEDIQRTALQWINEFIVIAKDIVIQYTPKIIKAVLPSLAHPVSVIRMYALETNQNLQKLVLETTMSYPEPSASMSDPSGSPHSMAATDLDDFSHNSGNNLSILRRTNRLDFGYGIHSISGDPFDYQATVSNLCLQFLNEHEETRVASLEWLLMLHKKAPSKILPSDDGIFPALLKTLSDSSEEVVRRDLQLLAQISFHSDHEYFRSFMVNLLLLFSTDRRLLESRGSLIIRQLCMSLDPERIYCTIADILENDEDLEFASIMIQQLNIILITSSELSDLRKRLRNLDNKDNQRLFIALYKSWCHNAVATFSLCLLAQAYEHAAIMLQVFAEMDITVSMLVQVDKLVQLLESPVFTYLRLQLLEPEKHPYLYKCLYGILMLLPQSSAFSTLRNRLSSVSSLGFLHGMPKNPPTVSTEVPKRQNIKASSSASSKQSEEPVIKYQELLQHFKNVQARHERQRRQALHSISNTNAFRSRKLRSGIASGSSSIAPTGPSRQGSIREDITMGFRRISIGGSGGSNGTISGPNAARPSTSTGRPTPTTSAASRMMPSRKGRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NBQ8</accession>
    <name>A0A162NBQ8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_72155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285784.1">
        <property type="nucleotide sequence ID" value="XM_018442606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NBQ8"/>
    <dbReference type="STRING" id="763407.A0A162NBQ8"/>
    <dbReference type="GeneID" id="29003512"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_72155"/>
    <dbReference type="InParanoid" id="A0A162NBQ8"/>
    <dbReference type="OrthoDB" id="411871at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="311"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD67744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="879" mass="97462" checksum="ED658DAB22CD3B6C" modified="2016-07-06" version="1">MANLQIGNMQGLPTELTSFLTTLQAQIMNVQNRTDQLERLAAENARLTTELDQARTTIANLQKQLGFQSAPDKNKEPGLEASTWASKASVSLSVTASKMSAVPSARHIAASVRMFALPSGPSGYEYVYIPRSRRLKHKEVRSSLRTLGVDSSRLLDINFPARGVIGILVHVQYADTFKAKLTTASVEILDAFDPLDPDNVADSKYASLYTHELANTAAMLHHDRCLQALQFLRPHVAIPVGHFFFEEGWISEDEIPTRTTLTNATGGSLFKSGTYRGSMGVSVLISSHCPYAVTQIPMPSKYALAVKIGSLRIVCLYLPPNMPTHDVLHVLSSIPLTHDTILCGDFNARLGSVTGDYASNSHGLALCSWIEERSLSVVNADLAPCIPTYISFRNNYEISSIIDLFITNMPLINPSLHIATDLSLGSDHCLLSLSFTYDLQHSTNMPPPLRKTWNLSRLNEPDVHALYAHTFNQNSTSLLSTLQDIVQNPPLTRPNIDAITDEFNSLIYDSLNSSIGHRPSRPNHWKSFWNAALQTAADRRNQCYKKWRLAIVLPATDLFIYLGVPFANKGISSKSIATHRRSGTLATMATLNSVGACCSGFSLLLSSRLYKTFVRPKFEYGLAISTLLKQDIKVLESIQDKCLCMIVGGHATSSTIVLKHICNLPSMKFRADALMAKFCIRSRFLPAQCLLSLLHHHHTVYSSLVSLGKTHLLSNLPPTLKLRSPSAVKNHFESIREAGFATFLQSNTQVLIQACRPVLGVDPILFLPASRVERSHLIRWRMGQLPGKPKECPCGSDHTSRRHLLDCPLVPMALFEQLPQPDQDQINRIDFAITSLPLSSQEPRPAYWIPLLTILWHIDVICNPDGDYSHETEHGALWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NBT3</accession>
    <name>A0A162NBT3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_187233</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290948.1">
        <property type="nucleotide sequence ID" value="XM_018439352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NBT3"/>
    <dbReference type="FunCoup" id="A0A162NBT3">
        <property type="interactions" value="556"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NBT3"/>
    <dbReference type="GeneID" id="29000258"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_187233"/>
    <dbReference type="InParanoid" id="A0A162NBT3"/>
    <dbReference type="OrthoDB" id="497380at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012959">
        <property type="entry name" value="CPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040059">
        <property type="entry name" value="PUM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389:SF0">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08144">
        <property type="entry name" value="CPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="49"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD72908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="554" mass="62925" checksum="7E0EF109C95752A7" modified="2016-07-06" version="1">MSEFTAKRKEAPTDAVVNNKKPKPEARREQRQTKMERKAHDRNFDMISEAKRIWEKLRRSDIKRDEQKQLMDEIMAVITGRVQEVIFKHDASRMIQTCLKKGNSDQRRQIAEELKGKYLELSKSMYGKFIVIKALEYCHWMRDSILAEFRGHIRKLIRHKEASNVIESFYSQYSTSAQRQELLSEFYGPEMTLFNHGGGAKSLDELLEKLPEKKDSILKYMGEMLDGCMDKGTVVNSIVHKALLQYLVLTDDKGRENVLGHIKENLQDIVHTREGARVAMLCLTYATPKDRKTIIKAFKPFLSKIACDEQGYIVLLRLLDVTDDTVLITKAVLGELSKNAKELFANKFGRRFFLYILAGRNTRYLSPETVQELKAGDAIRTSKKDPQQRSLELLKASSPLLIKMVADNAGTLMREKLSSQVVHEIMLHADGDKTAAINSILELAAEPIENENHIIVDRFANRIIKAMIKADTAEESNDKALAPLEFAPKLLEVIQPHLGYFATNFGSFVVVALAEEPSTKKDVRKALKPHKKEIEAAAEKNSGAKLLVELLAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NCW7</accession>
    <name>A0A162NCW7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_183191</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286264.1">
        <property type="nucleotide sequence ID" value="XM_018438732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NCW7"/>
    <dbReference type="FunCoup" id="A0A162NCW7">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NCW7"/>
    <dbReference type="GeneID" id="28999638"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_183191"/>
    <dbReference type="InParanoid" id="A0A162NCW7"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000100">
        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="5">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="353"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="237"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD68224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="46659" checksum="58854E5FA7063278" modified="2016-07-06" version="1">MLNNQQGCSALLENLFAPSMGCHTNEDGSTRPAPTDIPFGSLQAAQDYATAMNYCRDEIMQELDALDKSVIQPTDQLAALTKVIQKTIVKRQHKLLDYDRFRTSHQKYAAIADKGPSEEKHMIKLQSQLETATQDYFYLNNLLKRDLAEFLRLAALFIQPVLEDFYEIQCRVLGGMYGRIYEVAETHRAVFLTLDKSLQVGYEWRLGQRPVDQEMKQLSILQKSTGAQLGYRADSLEDRMKNRDPVYNNNPDRLSTASLKPAMSAKPLMAPKPTMAPKPTMTPKPAMGSKSYNHYQQQQQYEEKDEEGEYMGSRFGSLALSSPSPPQTTTNKPKTRMPPPPPPPKPKAKAKVAVVHYVIALYDLDAQQAGDLTFRQNDRIELIERTADEQDWWKGRLGDQVGMFPGNYVTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NH51</accession>
    <name>A0A162NH51_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_181154</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292248.1">
        <property type="nucleotide sequence ID" value="XM_018438425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NH51"/>
    <dbReference type="STRING" id="763407.A0A162NH51"/>
    <dbReference type="GeneID" id="28999331"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_181154"/>
    <dbReference type="InParanoid" id="A0A162NH51"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041545">
        <property type="entry name" value="DUF5601"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18151">
        <property type="entry name" value="DUF5601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="244"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="599"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="648"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD74208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="693" mass="79071" checksum="1BEACF03E16746C1" modified="2016-07-06" version="1">MNPQQNKTPDKSNVSQDPDELVDEFDEKMGLYEEQDHLDEKDGLRQETHEELEELLSDIPPTTASHGTPVNDEHHTTPTDSTQEQSASGNATGHDAEIRQIFTQFEASEETSTPETPTSTDSNGRRPSMAEIQRAADNTKGRERQEIAFDFNKFLEQMKRRSAHPITRYFKSFLQRFGQKSWTVAEQATIIQDFLSFIYGKMRECDVWKDLSDREFENAEEGMEKLVMNRLHNATFSPSTTDDKERDEILHQKMSIFRWIREEHLDIPVTENNASFMTFAETELLKINNYKAPRDKLICILNCCKVIFGLIKHVEGDAGADKFLPILIFVVIHANPPRLVSNVHPEHLQSEAGYYLTNLMGAITFIETMEAKSLSITKEEFETNIERTMNELQQERPSIAHDKQKISYDNAVHPSRSPQVQPQPLIDPIKAAQFLERSTNFAQKTMQKPLNFVGKIFQGLGDSSAGSSRPESPEDDEEARQRERSQVYYQQQRQLPPLPHQQQQQEQEQQYIQQQQYIQQQQQQRYGGGQWDTNQDPNVIYYQHQQQQQQQQYQPQHYGTYPPQGHYAQPIVPGLNTEPETVAPRTVPLPDLHQEARQLFDDNLKQILSIFPNVEPDVCFMILQANDGRVSQTVDTLLEIADPEVTKPSIAPTASPSPTSLPPAEAPAPAPALVPSPAPTAGDDITENDLIRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NIQ7</accession>
    <name>A0A162NIQ7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_149208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD70044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288084.1">
        <property type="nucleotide sequence ID" value="XM_018432233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NIQ7"/>
    <dbReference type="GeneID" id="28993139"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149208"/>
    <dbReference type="InParanoid" id="A0A162NIQ7"/>
    <dbReference type="OrthoDB" id="2266852at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="171" mass="19120" checksum="173C4C3A46315232" modified="2016-07-06" version="1">MYLSRTLQIRTPLVSDAGTDTHSLSINASASASSSSSSSQIYQVLANNAIILLKKGHVCLELIKHVGTEYLLLNIRAKAIDKGVIVDSKSNYLDINKHLAWLNRKDESTTIFHLDAAIVTIPHKAQTITLGYIEVKLSDFQVNPELEFLDLIRLETFARHFMQYQKAIPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NIV5</accession>
    <name>A0A162NIV5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_71515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288114.1">
        <property type="nucleotide sequence ID" value="XM_018442487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NIV5"/>
    <dbReference type="GeneID" id="29003393"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71515"/>
    <dbReference type="InParanoid" id="A0A162NIV5"/>
    <dbReference type="OrthoDB" id="2430203at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="32950" checksum="62E9D5466E6E3F7F" modified="2016-07-06" version="1">MNITINCSIPKVNAIKEALPQAAIHYCDFHVLCAWQHNLNSKIKLNTSFTSEQLGNYKTKWTENKELLRRWGRPYVSQQHQRYVTNNYVESWYNQLKIIYFGRTCIRRLNRLIFILTNDVEFFYEQEVECIHFNNGEMGLTENKLSRKSFAASKIQDDMLSSMILNPLGETGNSMDDYNEIARAELSRQGYTNENEGEVGEIVEERRIVEHRDTHGFDRIATYSTTMYHCFEDLQTLKTIPDLDQTDVEEMKRALAHAVQLMDKYRSKNPSYFRSLNTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PHS4</accession>
    <name>A0A162PHS4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_65104</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291007.1">
        <property type="nucleotide sequence ID" value="XM_018441397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PHS4"/>
    <dbReference type="FunCoup" id="A0A162PHS4">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162PHS4"/>
    <dbReference type="GeneID" id="29002303"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65104"/>
    <dbReference type="InParanoid" id="A0A162PHS4"/>
    <dbReference type="OrthoDB" id="272778at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF21">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="260"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="212"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD72967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="300" mass="33251" checksum="50CF9F2CCAB4A8DE" modified="2016-07-06" version="1">MSTGFRHAPTSRFLVSVVGGYSVLTKVLEARLDTRLELPLTHHELWRLFSTHWAFGSIGTTVIGTWLIYHMRVIERRYGTAKYTATISIITCTLLQTGALLLIGNSIGLKSIASGPYGVLFAILYQFHNQIPVCTRSERFGSLLNDKTYVYTAAISLFFSNGLASAIPCLCGLLVGAVYDANLGAIKEYRFPRWMSSFASRFVLPILNTSPVAGSSGSRTRPASSPAVSQRRGRETNRDLRQRRPHQQQEQQEQAAVVVPEEDINAMMSMFPEIGRQNVISALVQSHNDLNRAAEIILST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PIQ3</accession>
    <name>A0A162PIQ3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_65838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291277.1">
        <property type="nucleotide sequence ID" value="XM_018441540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PIQ3"/>
    <dbReference type="GeneID" id="29002446"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65838"/>
    <dbReference type="InParanoid" id="A0A162PIQ3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="352" mass="39895" checksum="5FC4F1A930E3FF63" modified="2016-07-06" version="1">MYSIKTENEDARNNIISLPQLAKCLETKYFWGLYLMFDFDCYQHIYVLSVYRSICIPFLNMFFRVITFGIGIALGSIYKSYYGDEILNIDQYKPFLERYDRERKEEEEIDKAKTKSNEIVQDTTNAVSPGSTETDFSEYSSTALPDSIKTASPGPISTTLPDIIKINLPDYIEIDSPDSIKTASMSSLSLRLADLIALENNFKDTEVDNGFSKVAHLRDRLEQDAGVEYGKKLSNNSLEEKSNAAYLAAFLHTMGPRRAKKIKHCILNGSITLGSNREPRCKNNAVYTSTAYLTVSGPGAACKFQYKFDLNDAEFMTDDMINSLETAHNIDDTPYIEIFITIVQLFLRRLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PRN7</accession>
    <name>A0A162PRN7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_64281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293397.1">
        <property type="nucleotide sequence ID" value="XM_018441268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PRN7"/>
    <dbReference type="GeneID" id="29002174"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64281"/>
    <dbReference type="InParanoid" id="A0A162PRN7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="351" mass="40451" checksum="3DD36E079CAED54E" modified="2016-07-06" version="1">MNINSFLNDAANLPTNAVEKLQLELQCRKEFEISFAIEFNLQQKVVENMAEAAYNFSNTVLGPKKIKKNPFNLYIKEMKNKRKLDRENYRLEEIIDSYNSMGPLEKGRYYKMAKEDSATLHQESSVSDVKRGAKSILTIMDTMKLSMNYNSLFLFWESGASSSRKIGRLLSGDTSSIFFKCIEEDGALKSFLEAMGNVERRPMREIQPATIAANDFRNKMNKRLISLFNEETGETRKSFPWKAIKNKKGTIRAVGWPEKVPFVPLSLMKDIEKEMLVDALDKGLISFSRSLDVTLCHHHHLVTCIKHLIEWPHKSCHKLLVIMHKQLKTDESASQDKSAMENNYLTILFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PV51</accession>
    <name>A0A162PV51_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_167732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292356.1">
        <property type="nucleotide sequence ID" value="XM_018435703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PV51"/>
    <dbReference type="GeneID" id="28996609"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167732"/>
    <dbReference type="InParanoid" id="A0A162PV51"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="303" mass="34320" checksum="F751D2746638BF84" modified="2016-07-06" version="1">MSSNTQQSKKTKKTTTKKSVQQTAGTAASTRQWEILPSLTVSAELDGTVLSTLSTMSTRLNESYSLLEKVYHNMGATNGQNNNSNHSPIGQALTTGEYIKYCLPTVSRLIRSQTRAVLATMPLTVNEGAFLTSNRPIADVVQSYTHQQAEVKSVLSAVVEEKTRRHILYMLQRAKALPEKIARQNRISRRRSRKRNILADYKVIHLADKTNLESKFGETVVDLLNYDMLSDIESDEEKNKTRYTPRNRHLLVDEYFTVLKKQRLANKGPDVIGNSVYPIILRNTELSNEKKARVAAWIHTRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PVG9</accession>
    <name>A0A162PVG9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHYBLDRAFT_177460</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292456.1">
        <property type="nucleotide sequence ID" value="XM_018437889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PVG9"/>
    <dbReference type="STRING" id="763407.A0A162PVG9"/>
    <dbReference type="GeneID" id="28998795"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_177460"/>
    <dbReference type="InParanoid" id="A0A162PVG9"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000702">
        <property type="entry name" value="ABC transporter (Adp1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF2">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007838742" description="ABC transporter domain-containing protein" evidence="15">
        <location>
            <begin position="22"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="784"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="819"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="861"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="900"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="929"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1013"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="80"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="360"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="616"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="670"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAD74416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1039" mass="115339" checksum="61973950465A5C4B" modified="2016-07-06" version="1">MRKRILCLLGGTVLLASTVKAEPSTNLSLSYTPVSYNPSFGIKTDDCPPCFNCLLPGFECLHFANCSDYNGKCDCPSGFGGDDCHQPLCGALSDGRNRSPRFGDECECPEGWEGINCNVCKTDNVCNAMVPTGQGTCYRGGLTVVENHQMCNVTNRKILDQLKTQIPQVTFSCNKPDETCDFQFWVDQVESFYCHLNTCAFEQEHGYDKNTTKYTCETIDCRCIKDEMLCGKDGSIDLTELLRDEIVGPASFTCTGSDCAFSEPAMDDLISAVFGDDSIFLSCSSGECLHYTQVPGFERPQRPINWLMIVSGIAGVTVFLLIVGAVVSYFAKRSSNSGGFILLPDDEAGKLMSDHTPTSLIFENLSYTVNKKEILKDASGIARPGEVMAIMGPSGAGKTTLLDILANRTKTGTVSGDIYLNGHRMSRSEYKKHIGYVDQEDTMIPTLTVYETILYSALLRLPRSMSEAAKKFRVGEVMQELGIDGIKDSKIGQTGDRSISGGERRRVAIACELVTSPSILFLDEPTSGLDAYNAYNVVESLVTLARDYNRTIIFTIHQPRSNIVTLFDQLVLLAKGRILYSGPQMHAQMYFKSIGYACPPGFNIADYLIDLTMQSIDPAQSPGQPQTDSNRPIQSDSLLNPIPTPYAPGSPSLADELENTSEQWASEMSARQERQRQERIRKQRQQIPAGLDVVVDDGSQVDQDGLTPHLRRLVDTYKSSQIAASTNDEIERSLAAASSSTPESIEQGVVYVPKPIITHERPGWLTQFRILADRTFKNLYRNPMLMFAHYAISVALALICGGLFYRVSNTIAGFQNRMGLFFFYEALLGFMCLTSLQVFSSERILFVRERANGYYSPGTYFLSKVLFDIIPLRVVPPLMMGLISYYMVGLVEGTANFFKFLLVLVLFNLTAAAACLVIGIVFKNGSMANLLSCMVMLFSMLFAGLLLNKDSMSPYFGWLKHLSFFNYGLEALLVNEMLYLQLIEERYGLNIDVPGATILSTFGFNAKNYWPDVIKLGVMFMSLIVFAFVWLVFFVKERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PVM7</accession>
    <name>A0A162PVM7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_158710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292526.1">
        <property type="nucleotide sequence ID" value="XM_018433841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PVM7"/>
    <dbReference type="STRING" id="763407.A0A162PVM7"/>
    <dbReference type="GeneID" id="28994747"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_158710"/>
    <dbReference type="InParanoid" id="A0A162PVM7"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="117" mass="13187" checksum="6F334CF6B717C9A9" modified="2016-07-06" version="1" fragment="single">MAEMMSGFDASGEINEKKRQIRDAIIKLDGEGSGSLSIEDLVSLRRDLEDSKVLLEQHSKTINILTSDKEVLDKKKAELDHKFGTLEKEYEELLDKTIAEEEAQVQNNSEFANTITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PYR9</accession>
    <name>A0A162PYR9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_143803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293596.1">
        <property type="nucleotide sequence ID" value="XM_018431072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PYR9"/>
    <dbReference type="GeneID" id="28991978"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143803"/>
    <dbReference type="InParanoid" id="A0A162PYR9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="83" mass="9210" checksum="F1800B03784923BC" modified="2016-07-06" version="1">MPVDLNKAQNISKGEDDEDSKNDGSDKASESSESCKDQEEHESSTFKHSDISVYSSKRRSTLFGNIVKNTAKRSVKSIDDIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162QA77</accession>
    <name>A0A162QA77_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_138912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299406.1">
        <property type="nucleotide sequence ID" value="XM_018430105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162QA77"/>
    <dbReference type="GeneID" id="28991011"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138912"/>
    <dbReference type="InParanoid" id="A0A162QA77"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="221" mass="24347" checksum="EF3BD60A737A194C" modified="2016-07-06" version="1">MAFTSSWLLPNKGTPSKIEVFVACISSEITTQYKDYRPADRPENLPKQKTSSCLASRTVPHISEEQCIHSTPAHVAFWDTRASNIVFKLPGVHVSTLPAPDYPVHVPTPNSLPMSDTPVPVDHADPGALGAVNITALIVTFTTALHSSQLPSPAGAPAPAHANISLSLSVHIERPIFIVWLRMEDTANRTSNWRTFTHLLNDNFYPIHVTQDVRNRNRSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T573</accession>
    <name>A0A162T573_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_128652</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441004">
        <property type="protein sequence ID" value="OAD66342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284382.1">
        <property type="nucleotide sequence ID" value="XM_018429230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T573"/>
    <dbReference type="STRING" id="763407.A0A162T573"/>
    <dbReference type="GeneID" id="28990136"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_128652"/>
    <dbReference type="InParanoid" id="A0A162T573"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05943">
        <property type="entry name" value="AACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002937">
        <property type="entry name" value="PRK03584.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF1">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="6">
        <location>
            <begin position="48"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="110"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD66342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="672" mass="75084" checksum="CD3A7E20196872AC" modified="2016-07-06" version="1">MTFSTTNKTDALSTTPKCLWTPSNVSQTEMDKFRKHVNSKYNLKLADYTELWKWSVTKIDAFWSTVWEYTGIISSQPATQVIDLSVRMDAIPEWFKGARLNFAENLLWCRDPKKIAIIAAGEGHPPEPMSYEKLYENVLQCAEAMKSFGVKTGDRVAAYIPNCPEAIIAMLAATSLGAIWSSTSPDFGTTGVLDRFSQIKPKILFSVNAVYYNGKTLDHTVKLNTVVKDLPSVETVVVIPFIKDFVGQPVQKSQSWDQFLSKVPKSALPKKISFAQLPFNHPAFILFSSGTTGLPKCIVHSGPGLLLQLKKEHVLHGNMHADDVFFYYTTTGWMMWNWLVGALGIGATIVLWDGSPFKPAPISLWKLVDQLKITHFGTSAKYIQSLQEAKISPKTECKLDSLKVVYSTGSPLKPESFDYVYEHIKKDIMLGSITGGTDISSLFAGHNSALPVYRGEIQCICLGMKIEAWADTNKPVYAQSADLVCTEPFPCMPVYMYQDPERTKYRNAYFDVYDNVWYHGDFVWINPKTGGVVMLGRSDGTLNPAGVRFGSAEIYNVADHFANHGIEDTLCVGQKIKDQDDERVVLFLKMKTGVVLTETLVKDIKTKIRFELSPRHVPAFILPIEDIPYTINGKKVEVAVKKILSGQTITPTGTLVNPKSLELYYNIPALKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T983</accession>
    <name>A0A162T983_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_174698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD66992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285032.1">
        <property type="nucleotide sequence ID" value="XM_018437320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T983"/>
    <dbReference type="STRING" id="763407.A0A162T983"/>
    <dbReference type="GeneID" id="28998226"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174698"/>
    <dbReference type="InParanoid" id="A0A162T983"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="197" mass="21915" checksum="322702BEC64D0200" modified="2016-07-06" version="1">MEQGVLIKDGDGGFFKTVSIHNTFLADNNKSKHCYAPQQLSNYGEKYGSSTINTLKVYTAKQEEWKNWFIEKKIQDGYTVSDEKLSFFLMEYVSNRGNKCRKNDDDTSVPLGLESVKGFEAMTAAMMSSRAANAPDIRKLQDKMSEFLAMGSNLFSSNSTTATTAATSSALLSTITTAAHIQLEKIHISTSILYRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TAI1</accession>
    <name>A0A162TAI1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mso1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_189142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441025">
        <property type="protein sequence ID" value="OAD67202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285242.1">
        <property type="nucleotide sequence ID" value="XM_018439611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TAI1"/>
    <dbReference type="GeneID" id="29000517"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_189142"/>
    <dbReference type="InParanoid" id="A0A162TAI1"/>
    <dbReference type="OrthoDB" id="2683368at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028095">
        <property type="entry name" value="Mso1_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14475">
        <property type="entry name" value="Mso1_Sec1_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mso1 N-terminal" evidence="2">
        <location>
            <begin position="183"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD67202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="273" mass="31316" checksum="03439800BB9D62FB" modified="2016-07-06" version="1">MGAHRVDYRMSKLIVLCKDCGKDVGMYPARHNCEYLLHAQLPPLTQLPESSLNERSPGSDSSSIKSYFGFSRQSSALSRQTSELSVGSVESDNTTSTTGTNAHSNKWARFQKPEETDGSYYDKFAANLPEQPETGKSLWGRVRQNEKWKQMTAEKSESRRTSGKLWGKLLNATQAMSVREDEPESDGSDYEGESHVSRILREYYGKQQKPLPDWMRESPVQRRVTVHTSENINRQQSGRRRLWETSEDRPTPRELERHSLRSSPRDHTRSYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TDN1</accession>
    <name>A0A162TDN1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_152619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441004">
        <property type="protein sequence ID" value="OAD66293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284333.1">
        <property type="nucleotide sequence ID" value="XM_018432962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TDN1"/>
    <dbReference type="GeneID" id="28993868"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152619"/>
    <dbReference type="InParanoid" id="A0A162TDN1"/>
    <dbReference type="OrthoDB" id="2596771at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="42932" checksum="B4230C82A81694E5" modified="2016-07-06" version="1">MQVDVMKISQSFCLDATHWISSRKTEVLYSLVTCHLQTGKGVFAVYMIANNNSVGPINRWLVHLRDMSSFSPLNISIDCSIPKVNTVKARYSDNFLENLALPHVAIHYCDFHVLRAWQGNMGSKVSLSGEYTSGQLNAYKKQLKDCLKDMLVESIYVTNNYAETWQNQLKKVYFKRTRVRRLDRLVSILTNNVEFYYEQEVERIHLNNGRMGPVENELSRHSLAASHITDDILPSMLLNPFGEIDSVSRTTSYNTVPAKTSRGIKYRASTFIWSIAKRRQEQKDDVVDVVGEEVEERGEVEKSRKTADVFDRICAHATAIYREFETFQISKTIPGLDQTKAEKIKIAFLDALRLSREYKEENPSYFKDLITQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TFX1</accession>
    <name>A0A162TFX1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyltransferase family 34 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_70194</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441000">
        <property type="protein sequence ID" value="OAD66813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284853.1">
        <property type="nucleotide sequence ID" value="XM_018442231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TFX1"/>
    <dbReference type="STRING" id="763407.A0A162TFX1"/>
    <dbReference type="GeneID" id="29003137"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70194"/>
    <dbReference type="InParanoid" id="A0A162TFX1"/>
    <dbReference type="OrthoDB" id="205108at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF4">
        <property type="entry name" value="ALPHA-1,2-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="61"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="418"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="432"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD66813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="697" mass="79585" checksum="96FF874F7878F063" modified="2016-07-06" version="1">MATELPLYKNNGPKKLQRPSRHIIIVLMLSAILIIFLLNRHVDQLPKPTQQDQVLWDVQAELPPPPKIQPTQPTQQQQQQPHKNSSQLSNDIKPASPHSDQHSRLSRPFADLTEDPDINQSGHYTHLVVIGSEASQGSRRQLIRSKYFGLRDNLLPCMQYDTDIYYTFWIHGGLPLPDTPLRRTYESEKMEWNDMQEIPARLEFEQANVIAWVENTLLVEKKITYDYLIIQDGYSFIQLSKTKFELDSGVIGQYTHSPYSLTSDTPLNFVWGTFDSTKSKSKSKNQNENQNKNQNVIVGSTAAKLALSKQSEIHHLYPDLPLLTGMYELYNSIQDTLKAVTDASLEPEAAAEEQERLIPAFIREDGPEGTQRFIDWENNIESVHAEDIVVKNVYQDSEFAALSDWSYLKPTRVCHQHGSFSANHPPVHPMDDDQDMSEDSEETDDETSSKDYSNSGGMGPSVAVLTSSYIYDACMEPSATRAAMNKRAYALEHNYAFVARSAEFAQQSATGHVRRKAVWGKIDVLEKALPKYDWVFWLDMDAVIMDQKRSLDDLLEELKADYQKQDNGFQFDKQIDMIVSRPSKDRMINAGVLLIRNTPWAMQFLRDLQDMSGWYQKGPSYEQGAMWELLQKPGNRERVLLLDRDDHTFNTFPSYYIPGDFVVHFAPDKCPNDAVVKGLNAADLILQGQRITAKDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TX39</accession>
    <name>A0A162TX39_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_69979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289722.1">
        <property type="nucleotide sequence ID" value="XM_018442192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TX39"/>
    <dbReference type="GeneID" id="29003098"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_69979"/>
    <dbReference type="InParanoid" id="A0A162TX39"/>
    <dbReference type="OrthoDB" id="10386716at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="244" mass="26813" checksum="369619DCDEEFE1CB" modified="2016-07-06" version="1">MVIVMVIVYLHKVVKFIFMISSYSDGVMTHHYLSTAAWRTSINHRTSILFHFQTLASPDEGLELLHKQFGSNIIAAKVDTTTTTSSCSSCSSCSSCSSCSSSSSSSSSSSSNIIGSGTDTIIEVVFGSLEYKTEALLKGVCVEYRESKMCKVTATRTLDPFYDYTILSIWGLPLESLKDAERKVQTSIAPLLGKVVGLVCSVHPVCGFYDGSMEVVLRGHEHSLLNTIYLRSYRAEFPLRKTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TYN3</accession>
    <name>A0A162TYN3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_100445</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290082.1">
        <property type="nucleotide sequence ID" value="XM_018427589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TYN3"/>
    <dbReference type="FunCoup" id="A0A162TYN3">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TYN3"/>
    <dbReference type="GeneID" id="28988495"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_100445"/>
    <dbReference type="InParanoid" id="A0A162TYN3"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000119">
        <property type="entry name" value="Ubiquitin specific peptidase 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF758">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="9"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD72042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="301" mass="34211" checksum="AD05185AAA8CF414" modified="2016-07-06" version="1" fragment="single">WKISRRIGPGLLNGMNTCFLNSVLQCLTYTPPLAQYLLTKSHRSTCKITSFCALCAMEVHINRCLCDPKSLVKGAAIHPKYFTSSLKALSKTMRLGEQEDANEFLMFLFAAFQKSSTYGLGKLDPKVEESTMIHQIFGGRMQSQLRCYNCKATSSNFEAFLDLSIDLHKADTIEQALQNFIKVDIIGGGKDSENKYMCSSCKQRVTAGKQMTLCELPMMLNIHLKRFTFDMQRGYMRKVTTDVKYPEVLDMAPYVSKEKHCQKAIYRLYAVLVHFGGGCSSGHYYAYVKSPEGKWYRMDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U6Z2</accession>
    <name>A0A162U6Z2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_64913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292002.1">
        <property type="nucleotide sequence ID" value="XM_018441368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U6Z2"/>
    <dbReference type="STRING" id="763407.A0A162U6Z2"/>
    <dbReference type="GeneID" id="29002274"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64913"/>
    <dbReference type="InParanoid" id="A0A162U6Z2"/>
    <dbReference type="OrthoDB" id="2289193at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="179" mass="20593" checksum="B5D1BA3D8775087E" modified="2016-07-06" version="1">MIELKKDATVEPKKQNSLHVESLKITDEHLKFIQDLLDKCCTLMLGQMREELFRKYPELQDQNLSISGLHKHIINNIGFTLKRTKPVEEKRNDSKTIELRKVCVDSMHTNGLLYKTNCIFVNKAGFNANLIREQGWSKKDKASIVKTKLKKVLNISIFAGISYQGFESVWAKLTPDDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UA04</accession>
    <name>A0A162UA04_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_112892</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291583.1">
        <property type="nucleotide sequence ID" value="XM_018428315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UA04"/>
    <dbReference type="FunCoup" id="A0A162UA04">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UA04"/>
    <dbReference type="GeneID" id="28989221"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_112892"/>
    <dbReference type="InParanoid" id="A0A162UA04"/>
    <dbReference type="OrthoDB" id="432299at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000001">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="57"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD73543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="141" mass="15826" checksum="568B582AE1A1D9B2" modified="2016-07-06" version="1">MSDVPEFPSRDGPQRLVAAATKQPKNRQKVRLEPGHSPLDWARLKSSGKDLRGVSQLSRYTLDDIKRHNTLADAWTAIQGKVYNITPYLKFHPGGVKDLMRIAGKDGTRLFMLTHSWVNTDFMLDACMVGFLVPGRSSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UE24</accession>
    <name>A0A162UE24_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_166804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293612.1">
        <property type="nucleotide sequence ID" value="XM_018435495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UE24"/>
    <dbReference type="STRING" id="763407.A0A162UE24"/>
    <dbReference type="GeneID" id="28996401"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166804"/>
    <dbReference type="InParanoid" id="A0A162UE24"/>
    <dbReference type="OrthoDB" id="2285313at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="329" mass="36315" checksum="A6E9123188AC58BB" modified="2016-07-06" version="1">MALCLQELFGLVALANEAKKIWILLKALHPEIAYEVEKSGLPHSWDKLVCWAAKVEAVKEKYHYSDLRLVPKFEDALSELIQEFRSMKIYLFDTCHFLPQASGSFRFGLSGFGGSGPCGSGFDTAVNMVETTLVYAAKHARVVNLSSSKNPYTHNKGKAVDKTHLYAQGQLNTFPTNDIYMTLAPDLSPPIGSSPLAPKSRYLHPPPRELPVHISCKDVWERLKSVDADDWETQSLETNAANLNSDSKLDGYNSNSTVYNYHYNYKDFASSQPLRALITINGQVIPAIFDLSASVSIISKALALCLGLVPNVNRLPFSSLDGQAHPPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UF00</accession>
    <name>A0A162UF00_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Plasma membrane proteolipid 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_124049</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292693.1">
        <property type="nucleotide sequence ID" value="XM_018428967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UF00"/>
    <dbReference type="STRING" id="763407.A0A162UF00"/>
    <dbReference type="GeneID" id="28989873"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_124049"/>
    <dbReference type="InParanoid" id="A0A162UF00"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF42">
        <property type="entry name" value="UPF0057 MEMBRANE PROTEIN ZK632.10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD74653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="57" mass="6385" checksum="BECF6CEA66D68B23" modified="2016-07-06" version="1">MALTCSDIFKFFFAVILPPLGVMFEKGCGCDFVINICLTCLGYIPGIIHAFYIILKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UIK2</accession>
    <name>A0A162UIK2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">homocitrate synthase</fullName>
            <ecNumber evidence="5">2.3.3.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHYBLDRAFT_132711</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>acetyl-CoA + 2-oxoglutarate + H2O = (2R)-homocitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58884"/>
            <dbReference type="EC" id="2.3.3.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:12930"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.14" evidence="5"/>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293533.1">
        <property type="nucleotide sequence ID" value="XM_018429516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UIK2"/>
    <dbReference type="FunCoup" id="A0A162UIK2">
        <property type="interactions" value="408"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UIK2"/>
    <dbReference type="GeneID" id="28990422"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_132711"/>
    <dbReference type="InParanoid" id="A0A162UIK2"/>
    <dbReference type="OrthoDB" id="2015253at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004410">
        <property type="term" value="F:homocitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07948">
        <property type="entry name" value="DRE_TIM_HCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.260:FF:000002">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000032">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02222">
        <property type="entry name" value="Homocitr_synth_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050073">
        <property type="entry name" value="2-IPM_HCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048253">
        <property type="entry name" value="DRE_TIM_HCS_fun_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011872">
        <property type="entry name" value="Homocitrate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054691">
        <property type="entry name" value="LeuA/HCS_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02146">
        <property type="entry name" value="LysS_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277:SF48">
        <property type="entry name" value="HOMOCITRATE SYNTHASE, CYTOSOLIC ISOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277">
        <property type="entry name" value="HOMOCITRATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22617">
        <property type="entry name" value="HCS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="15">
        <location>
            <begin position="43"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAD75493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="452" mass="49830" checksum="AF05B0B68781D27F" modified="2016-07-06" version="1">MSPPRDLSQTPAVTAAPAQRTREPFVSPYMPKYPDPMSNISSFKIIESTLREGEQFANAFFDTAKKVEIAKALDAIGVDYLELTSPAASEQSYNDCKTIAGLGLKAKILTHTRCHMDDARLAVETGVDGVDVVIGTSSYLREFSHGKDMEYITDKAIEVITYIKSQGREVRFSTEDSFRSDLVDLLSIYKAVDKIGVNRVGIADTVGCANPRQVYELVKTLRSVVNCDIECHFHNDTGCAIANAYAALEAGATHIDTSVLGIGERNGITPLGGLFARMYAADKDYVMGKYDLKLIRNVENLVADSVEVAVPFNNYITGYCAFTHKAGIHAKAILNNPSTYEILKPEDFGMSRYVSIGHRLTGWNAVKNRIEQLRLTDMTDDDAKAVTQKIKELADIRPLSLDNVDSLLHQYHDAKKTSSHITILEKIATPDQLAEPAVKASTTQKQQQPIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UJ41</accession>
    <name>A0A162UJ41_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_63207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294622.1">
        <property type="nucleotide sequence ID" value="XM_018441085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UJ41"/>
    <dbReference type="GeneID" id="29001991"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63207"/>
    <dbReference type="InParanoid" id="A0A162UJ41"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="263" mass="30938" checksum="CAA8DE7B0718B26A" modified="2016-07-06" version="1">MRRIFELPSHAQNVRLTITCAECLTYHHLRRMFDLPSHVQNVRLTITCAKCLTYHYMRRMFDLPSHAQNVRVTITCAKCSTYQHMRRMFELPSHARNVRLTITCAKYSSYHHMREMFDLPTHAQNVRVTITCAKCSTYHHMREIFELPSHARNVRLTNTCAECSSYHHMREMFDLPSHARNIRVTITCAKCSTCQHMRRMFELPTHARNFRVTITCAECSTYHVVLQLYFSLYTRALGLPTKLVICKSDTGYLAVCYNYLNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UML4</accession>
    <name>A0A162UML4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_186260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294423.1">
        <property type="nucleotide sequence ID" value="XM_018439211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UML4"/>
    <dbReference type="GeneID" id="29000117"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_186260"/>
    <dbReference type="InParanoid" id="A0A162UML4"/>
    <dbReference type="OrthoDB" id="2281291at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="392" mass="44749" checksum="EEB18E8CCD8FC1C4" modified="2016-07-06" version="1">MSTESRLSSWILKNNKDLLSSKSTRQSLLITQCHYAANSTKSSNILVLLLTDGQYWIPALMDTKKIKEVLEISQALENHLAKLVGMVINISKTMFAVYRRGDALSPHLIVQEYELAELKQSGQQTTPKEIHEHPDIKLWLDELQTAMPDLEQESINELYPSKDRKEIDGFLNQYESVVSGFEYLMLHYYNEIIKTNLKRSNNIDHVKEWRQRMKTNAKKRKVSTWNIIDSGRDLWKDKIVDMMSLIYLDYKSDVSSEKDLIFDSYPTEHQEAKDDNGNDNEEEVSGQIKIENESQTAIDHKSHDSNTKKSTEDQDTQFSFDSIKNNTNNTNNNNATTSSWSKVGQNSSSSSIDSTEFLSPVELPGLNTDHDISTNSILGQTEGVGSYDFENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162URI4</accession>
    <name>A0A162URI4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_108812</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295692.1">
        <property type="nucleotide sequence ID" value="XM_018428068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162URI4"/>
    <dbReference type="FunCoup" id="A0A162URI4">
        <property type="interactions" value="983"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162URI4"/>
    <dbReference type="GeneID" id="28988974"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_108812"/>
    <dbReference type="InParanoid" id="A0A162URI4"/>
    <dbReference type="OrthoDB" id="1093at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040798">
        <property type="entry name" value="Rpn9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18261">
        <property type="entry name" value="Rpn9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="176"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD77652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="382" mass="43504" checksum="C5CF13DBDC36D498" modified="2016-07-06" version="1">MEIDFDIPKFLSQERHKAPANLQHYFSTFEDLYERKLWHQLTLKVLEFFKEPASGPFQIPIYQQFVSQWEKQINALSLVSIALKAATHFKDPNDAVEFLEILVTKVDKPDTKDVHVHAVMEAANFKLKLNQLDQVKKAIDSSEKTLESLDSVDTAIYASFYRVSAAYYKAKGEYAAYYKSALLYLACVNVDELSNEEKVERAYDLAIAALLGEMIYNFGELLMHPVLDALTNTQNDWLRSLLFAFNSGDIGKFEALAPHFAKLPLLQENAASLSRKICLMSLIEAVFRRAGDSRDIPFSDIAAETRLPVEEVEHLVMKALSLNLIRGSIDQVDQIVTVTWVQPRVLDKDQIDGMRRRLEDWDNQVKKISGFLSEQGGEVFAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UUH0</accession>
    <name>A0A162UUH0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_141978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD78113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296153.1">
        <property type="nucleotide sequence ID" value="XM_018430715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UUH0"/>
    <dbReference type="GeneID" id="28991621"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141978"/>
    <dbReference type="InParanoid" id="A0A162UUH0"/>
    <dbReference type="OrthoDB" id="2260752at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="59649" checksum="EF4FD4F8445291EA" modified="2016-07-06" version="1">MSSQHSAANSLPHEEQSPLTEVGIPSPILSEQTHLTKIGDISPLLGSTALSINGNIEMIYTSLDSLPPLSVVGSVPPTLVPTVPSAINSNTSSSITLEMLLASAKKDLSIKKNNFYVAYANYVSLSKVNPMSDAVRHASSIKREAQELFEDAQKTLKVLEKANAPPAILEDKKSMVVPSNLPFLQLCTETRVKHNRDVFDSVYDFCQEFTMVLESYSLSLDLCWKRLLPICLNKEERSWFEDKLKGKAYKWKKTEGILLDHYDTPFRRFLNMGRVWKMMQKKGESVRAFGAKFQTARRQASLENGIQIVLCFWWNLHPEVREASLIPLSANYGTKLPSKVENIISLVSVATSNSTALLNQPAECGTPAKWKSFADAYSISSSISHKGKKRAIARDNDPKHAKKSWNFKKAIKDNVSRMAVRSPADRSVASPPACGGFPPSRDSHFSVRGNSSPASSSSTSWSMDQDNTSALAKMILNSIHILKELALVCIGTDYMSTLGIDIYGLPLSYDDADSSEERREADRCFNNKSDLLESLERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UZ45</accession>
    <name>A0A162UZ45_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable enoyl-CoA hydratase, mitochondrial</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_107085</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296963.1">
        <property type="nucleotide sequence ID" value="XM_018427975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UZ45"/>
    <dbReference type="STRING" id="763407.A0A162UZ45"/>
    <dbReference type="GeneID" id="28988881"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_107085"/>
    <dbReference type="InParanoid" id="A0A162UZ45"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000019">
        <property type="entry name" value="Enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004517">
        <property type="entry name" value="PRK05862.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD78923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="263" mass="28349" checksum="E6C9B28170707C72" modified="2016-07-06" version="1" fragment="single">STESPKQYDNILVETKGKVGLITLNRPKALNALSSQLFVEINEALRSFDADKDIGAMVITGSEKAFAAGADIKEMKDNTFIDNYKKNFLGHWAEMTEIKKPIIAAVNGYALGGGCELAMMCDIIYAGEKAIFGQPEIKLGVIPGAGGTQRLVKAVGKSKAMEIILTGSVNLNATEALQYGLVSKVVPADQLVDEAVKTASKIASMGQPSVQMAKEAINKSFDVSLDAGLRWERIFFQALFGTADQKEGMAAFTEKRKPTFTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V663</accession>
    <name>A0A162V663_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_75571</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CYC8/SSN6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298302.1">
        <property type="nucleotide sequence ID" value="XM_018443074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V663"/>
    <dbReference type="STRING" id="763407.A0A162V663"/>
    <dbReference type="GeneID" id="29003980"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_75571"/>
    <dbReference type="InParanoid" id="A0A162V663"/>
    <dbReference type="OrthoDB" id="418911at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000403">
        <property type="entry name" value="General transcriptional repressor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000078">
        <property type="entry name" value="Transcriptional corepressor Cyc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051630">
        <property type="entry name" value="Corepressor-Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017:SF1">
        <property type="entry name" value="LD02225P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4 9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="128"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="202"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="274"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="308"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="388"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="620"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="662"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="831"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="865"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="914"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="963"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD80262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1003" mass="112498" checksum="D1F50CF3254B795D" modified="2016-07-06" version="1">MAATVPPQQPQPTSTAQKLALVNEQTWLTMGNLAEMMTDYDKAINCYESALRHNPYSVAALSQIASLCRGREQFGRAVDFFKRILDIQESNGETWAALGHCYLMMDNLQEAYQAYQQALYHLSNPKDPKLWYGIGILYDRYGSLEHAEEAFSAVMKMDGKFEKANEIYFRLGIIYKQQQKFDLSLQCFRYILHSPPRPLTESDIWFQTGHVYEQQKEYESAKNAYEHVLSENPDHAKVLQQLGWLYHQQNTSFCNQSLAIQYLTRSLKADSNDAQSWYLLGRCYMAEQNYNKAYEAYQQAVYRDARNPTFWCSIGVLYYQINQYRDALDAYSRAIRLNPYISEVWYDLGTLYESCNNQIQDALDAYQRAAELDPSNPHIKQRLELLRKSQSVQSTQGAGSAPVPQDVSNPSQYQNGPGAQPLNGPSSYGQSAPSGPPSSMSAYHTAASNSQSRVDDRAPIPQLPIHAHSSHEPISGPPRDLPMPGGGGGGGGGSSGRHSPRSYPYTPTRDELRIPDIGGGGRAPTPTERSQMNPIMHEDNRHGSVGPSPSQPNLPPMSMRQSPFVKSATLDPSTRSPNPEGGRAAQLVSQSPNPRPPSRGPLHLQGSHYDAPQHASPRSGHHETYGSAHYDHTLRPANYDHENAPYRPQRPSESGPMYGSKQQQAQQHAHQQAQQQQAQQQAQAQAQQQAQQQAQQQAQQQAQQQAQQQAQQQAQQQAQQQAQQQAQQQAQQQAQQQAHQQAQQQAQQQAQQQAQQQAQQQAQQQAQQQAHQQAQQQAQQQAQQQAQQQAQQQAQQQAQQQQGSYHSESQRHPPVVKNEESSIYRSVPRKMPIDEERRMEDHSRMESRARTTEYRPYGAPIMADPKVEKMEFKKEDKSQESDGGLARQGMDEDFDESAADALLSIGGSRPIVAGEKRSHEKEGPEEESKKTKQAHEEEEPENMDKDQQGSSSALVPAADKTETPSVQPQDQQQMERDDKPSQIEPQLSEERPSSPADHTAGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WBN2</accession>
    <name>A0A162WBN2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_152903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441006">
        <property type="protein sequence ID" value="OAD66105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018433023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WBN2"/>
    <dbReference type="GeneID" id="28993929"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152903"/>
    <dbReference type="InParanoid" id="A0A162WBN2"/>
    <dbReference type="OrthoDB" id="5596236at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="178" mass="20810" checksum="6B0D6B9E9C12E479" modified="2016-07-06" version="1">MRNESKETQHNTTQHKHSSGLASRDQVFVSREDNTKHKIKAITFLLLKNQKTDSLQFSKAIEISNEHASNLDSQIVLDADIFLSILLKLLSFVNFADSCTNLNCLENMDGSEVMHRLWNRDIASVLNFRYILNNLRCDGTISVRFTRLIRIGRIRRKAEEDLQEGRRLRQRLTRLQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WSY3</accession>
    <name>A0A162WSY3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3 11">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_134980</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3 11"/>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288795.1">
        <property type="nucleotide sequence ID" value="XM_018429689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WSY3"/>
    <dbReference type="FunCoup" id="A0A162WSY3">
        <property type="interactions" value="583"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162WSY3"/>
    <dbReference type="GeneID" id="28990595"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_134980"/>
    <dbReference type="InParanoid" id="A0A162WSY3"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="12">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="9">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD70755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="151" mass="16703" checksum="08F007BAF18E61FF" modified="2016-07-06" version="1">MEQTYIMIKPDGVARGLVGEIIKRFEQRGYQLAALELMNPTKQLLEEHYQDLKGKGFFAGLIEYMASGPVVGMVWVGKDVVKVGRKMLGETNPLASAAGTIRGDFCIEVGRNICHGSDSVESAQREIAMWFPRGVKVASRNTSLHALIYEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WV84</accession>
    <name>A0A162WV84_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_148252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OAD71035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289075.1">
        <property type="nucleotide sequence ID" value="XM_018432048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WV84"/>
    <dbReference type="GeneID" id="28992954"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148252"/>
    <dbReference type="InParanoid" id="A0A162WV84"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="62" mass="7280" checksum="C6149A32A40138FB" modified="2016-07-06" version="1">MDKNKKLIIKTYQQQKFIHTANISMYLIEWLVFENWFSLNNSQCALCLVLTKVLPSLTSEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WXT6</accession>
    <name>A0A162WXT6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_187794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289465.1">
        <property type="nucleotide sequence ID" value="XM_018439425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WXT6"/>
    <dbReference type="GeneID" id="29000331"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_187794"/>
    <dbReference type="InParanoid" id="A0A162WXT6"/>
    <dbReference type="OrthoDB" id="2290849at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="Multiheme cytochromes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="276" mass="30434" checksum="3CBD3F63C0F8572A" modified="2016-07-06" version="1">MTRPHPHSVQGQRLNKKQVCLSNDISVEPFEKSNHTSRPGNMRQAVRMRSSSTFSTSASIPRSTDNVAIDAHPLAFPYHNDTIFLPTVESGRTRFDSISTSSSMQISRTPSPALSTSSSSSAASFTSTPESSPCSKHVLTENNNITLKCEACHRDNADERVKRRDTRISSFFGRVDLFSNTRTPDTTVTDSPVTCHQCHPCNQSTIPVGSSPGYLAETAKKESRSTFNTYAPSSFSYSRTPPPSKSYMSFASFSIPESSRQLCIRFLKKLMPSKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y2D2</accession>
    <name>A0A162Y2D2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_68503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296035.1">
        <property type="nucleotide sequence ID" value="XM_018441965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y2D2"/>
    <dbReference type="STRING" id="763407.A0A162Y2D2"/>
    <dbReference type="GeneID" id="29002871"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_68503"/>
    <dbReference type="InParanoid" id="A0A162Y2D2"/>
    <dbReference type="OrthoDB" id="2281978at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD77995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="404" mass="44937" checksum="2DF6817078F4F0BB" modified="2016-07-06" version="1">MPPHKSPLEYPTRSFVTSRINGYCPPVATHPAGRKKLTDVLPSIQGQKAGVANGRSRNTFCLPSDDEEDVDENESSDDEREVRPKHPLGPSNRSAPVKTGRAAQPLPSDDEDEDDSEDSDQDNQGLLKGHPSLWSNSQRQMRANPTTMRASHPVFDHQKAFRARHGQEQYNSSNSSSSLPRHNTSAPVSASTSAEDLALHNYLHNQESDDEVLGQSRRSGQETHLQQLQHTQRYQQSQLSQFQQQHQSHAPTNKAAQRGQSSVQPQRVTMSGMDLLKQLEQERAEAKRQKPKMSSSTAKIEGLLAKLPEPGLHNISFQQMHVQTPLPKPKKSRSPQAWTGTYEPQRSTMPAVHRTVPTYMAQSVYGYPPPVSTPQRSGNSGKMAHQDTLRPSSSAGDLQPLQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YD33</accession>
    <name>A0A162YD33_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate esterase family 4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_106940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297965.1">
        <property type="nucleotide sequence ID" value="XM_018427967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YD33"/>
    <dbReference type="GeneID" id="28988873"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_106940"/>
    <dbReference type="InParanoid" id="A0A162YD33"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF98">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="123"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="340" mass="38699" checksum="E25ECCE04725F1CA" modified="2016-07-06" version="1" fragment="single">PIMRNILPVEAPNFLPDFDTLNLFPRIPPKGPILKKSKLQLKDYPPTWATPPVDGPDIEKVLESIDWEYVPNIPVRNSTSSGDLDMSKYDVLVDDSCWWSATGCVEPKLDYLPVDIYECPAPGHFGLTYDDGPMVPNKSEDSSSDSWEEPDLYKFLNENDQKATLFYVGSNVALYPDIAKRAIDSGHDICLHTWSHPPMTTRTNEQIVAELYWNLRAIKEATGITSKCWRPPYGDVDDRVRGIAHQMGLRTVLWTRDSQDWQLDSPGSTLTPKDVDGYFEQWIADQVAGKNNDNGHIGLQHELSDTTVRVAMKWLPRMQEAFNVTTVHQCLKMEKPYWES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZCB5</accession>
    <name>A0A162ZCB5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_137570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="4"/>
    <dbReference type="EMBL" id="KV441027">
        <property type="protein sequence ID" value="OAD65811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283851.1">
        <property type="nucleotide sequence ID" value="XM_018429864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZCB5"/>
    <dbReference type="FunCoup" id="A0A162ZCB5">
        <property type="interactions" value="261"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162ZCB5"/>
    <dbReference type="GeneID" id="28990770"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_137570"/>
    <dbReference type="InParanoid" id="A0A162ZCB5"/>
    <dbReference type="OrthoDB" id="202234at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="6">
        <location>
            <begin position="102"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD65811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="280" mass="31377" checksum="0A270540C5CADEC6" modified="2016-07-06" version="1">MIEDISLALGRVHWSVWAVAPIVFAALYRKHGSFYYRSLVSIICLAISAIFGMCASLLLPLVRRSDLTNWAVARLYYNLTRIFLGVSVKIEGAENLKVDGPAVYVCNHQSSMDVFVMGSVFPKATSVVAKKAIKYYPILGWYMTLSNAIFLDRKNRDSAIKEAQKASDDIHRKNTNVWLFPEGTRGHESEITMLPFKKGAFYMAVQAQVPIVPIVVANYNHIYSSKRKEFKSGEITVRVLPAIPTKNILAESEAVDQLATGTREKMLVALREISVNKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZLA5</accession>
    <name>A0A162ZLA5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_160428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285621.1">
        <property type="nucleotide sequence ID" value="XM_018434180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZLA5"/>
    <dbReference type="GeneID" id="28995086"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160428"/>
    <dbReference type="InParanoid" id="A0A162ZLA5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="84" mass="8132" checksum="F85C28277898A33D" modified="2016-07-06" version="1">MLAEVPKIPDLLVPGLPDVAENPVAGPDAGAGADADTDADADADADAEAGANANANADADSDADADANTDDAAVVVDDDVEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163A6I9</accession>
    <name>A0A163A6I9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MABP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_187790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289451.1">
        <property type="nucleotide sequence ID" value="XM_018439423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163A6I9"/>
    <dbReference type="STRING" id="763407.A0A163A6I9"/>
    <dbReference type="GeneID" id="29000329"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_187790"/>
    <dbReference type="InParanoid" id="A0A163A6I9"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023341">
        <property type="entry name" value="MABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF0">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51498">
        <property type="entry name" value="MABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007841452" description="MABP domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="MABP" evidence="3">
        <location>
            <begin position="123"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD71411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="693" mass="78072" checksum="69D3DA7D4AD388E1" modified="2016-07-06" version="1">MYICFWNLILVCTVIGYFCTAVQAYITDIKLVTCDGHRACPNFPGYKKLETNLNAGTKRSQIYMHIKDDPSSDPITDLLILKTPDPPKATGWTRLETDLNHNTVFDNQTAIWLYFTKDKRLSVNPVTSIIIKEGDSPVVGAEYRRLPVDLNEGVGGMPLYMFYSQLGPKEYLFDKNPITALTAKACFTDVCYMDGWERVEKDANEGVIVGMRIYLFYQRKRNSPPVTDIVLVLDDQTAPEGYNKVEVDLNFVTFRGASIYLWYKTLSNPSEEEKSTAIQQVAIEYGQNAVAPLGWERLSVDLNSNHDGKGGFGEPTFLFIQRGYHELPPRQPLVFRKDGTFKIVQLADLHFTNEVGKCKDTPVEFDCKGDDSTIATIERLLDHEKPDLVVFGGDNIDGNGCYFVFVLFCFVLSFVCVCIYIQNLVLIPKTYISGAVTDARAATFKFAEPVIKRKIPWVAVFGNHDDENDLTREELFEVIRRMPFSLNERGPLELPGTGNFALQVFSNATLEAHALTIYFLDSHGLATKDTYDSIDQEQLNWLQETSANYAQSGKGTQKPNALAFFHTPIWEYHGAEDKSVPKLGDQRETISSPRKKKNLSVLDAFVKAGDIKATGWQALHAYGHDHVNDYCIEQKGIQLCYSGGLGIGGYGAAHLGWPRRARVWEINRFGEGIVTWKRLDDGALTLHHYQTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AR88</accession>
    <name>A0A163AR88_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_110658</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293271.1">
        <property type="nucleotide sequence ID" value="XM_018428177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AR88"/>
    <dbReference type="STRING" id="763407.A0A163AR88"/>
    <dbReference type="GeneID" id="28989083"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_110658"/>
    <dbReference type="InParanoid" id="A0A163AR88"/>
    <dbReference type="OrthoDB" id="446113at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12344">
        <property type="entry name" value="RRM1_SECp43_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF10">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="91"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="197"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD75231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="298" mass="33724" checksum="C9F6FC4C28D01DDE" modified="2016-07-06" version="1">MGNLEAWMDERYLQELWTSIGENVVVKLMRDKRTSISEGYAFVGFVSNMAAQRALATIHGTQIPDTNLSFKLNWASGGGIQDKKEDRLEEFSLFVGDLDTEVDETYLLSFFQHRYPSCHSAKIMTYPTTGQSRGFGFVRFHDPIEQQEALIEMSGMYCKSRPLRVSLATPKNNQLRYQQLSLKAPALIQQPTSPNNTTVFVGGLLSAVTEDELRCYFSPFGEINYVKIPPNKSCGFIQFVSRRSAEVAMEQMNGFQIGSSRIRLSWGRTHQEKPHGPLTFAYPPHTTTHPDTGLNYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B4E2</accession>
    <name>A0A163B4E2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_71714</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SHO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296281.1">
        <property type="nucleotide sequence ID" value="XM_018442529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B4E2"/>
    <dbReference type="STRING" id="763407.A0A163B4E2"/>
    <dbReference type="GeneID" id="29003435"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71714"/>
    <dbReference type="InParanoid" id="A0A163B4E2"/>
    <dbReference type="OrthoDB" id="5983572at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd11855">
        <property type="entry name" value="SH3_Sho1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035522">
        <property type="entry name" value="Sho1_SH3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="247"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD78241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="320" mass="35544" checksum="D323796107E457AA" modified="2016-07-06" version="1">MPILKNTLAKENMFFLCTSGIAYCGWIIAFGSACDLKVQSGLTWWVIIYELLLTSVITHLTFSGLFMQYRLAVLTFLAASISLLSQQIEISLLEAKLLDDSAQKAKAAGLIILIIIRFVWVIVFGSESDSAVSHSLARLVSRNNSVTQSPSRRIDPADMSSEKIFYRDNSITRRSMNLLPNSNSSPIQSPPHTFSYNSTGPHNDINPTTTNATNTANTTSNPTSPYLENVASDAVPSMVHGPLEPMEYTERVEALHAYQANRDDPTELSFEKFETLEIASRAGNWWQARKMDGTVGIIPSNYHRNNNKCINAILANEFQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BCB9</accession>
    <name>A0A163BCB9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_104182</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298621.1">
        <property type="nucleotide sequence ID" value="XM_018427822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BCB9"/>
    <dbReference type="STRING" id="763407.A0A163BCB9"/>
    <dbReference type="GeneID" id="28988728"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_104182"/>
    <dbReference type="InParanoid" id="A0A163BCB9"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001666">
        <property type="entry name" value="MDS1 and EVI1 complex locus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD80581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="68" mass="7794" checksum="44B1DACEE14929D9" modified="2016-07-06" version="1" fragment="single">CLFPACGKTFARLYNLKSHSRTHTDDRPFGCQVCQASFSRNHDLKRHVKIHGGDKPYHCIGCNKTFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163CRK2</accession>
    <name>A0A163CRK2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_153804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441033">
        <property type="protein sequence ID" value="OAD65090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283130.1">
        <property type="nucleotide sequence ID" value="XM_018433261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163CRK2"/>
    <dbReference type="GeneID" id="28994167"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153804"/>
    <dbReference type="InParanoid" id="A0A163CRK2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="226" mass="26563" checksum="0836E989B2557216" modified="2016-07-06" version="1">MRALGFTPASRLYTVREKAIPTFHRSDTRYTIDYSFGHVSFRPRLANTGIMHLSPCCTCRSFLTVDLAIQDHAPSYGTWRFNSFLSLKFRISTSSTVIKLTAQEYDKQASRTHQRTTNSHQTQRVTVPRLSHSEDRRIESENIDYETVPAIEERHRYLFLWSNTPRLENDEQRKKYFFKVFCQRLISDNGWTIRILMTYLKALAFSSSTLGAQFEQERAYNRMHPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163CSK4</accession>
    <name>A0A163CSK4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_176230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441029">
        <property type="protein sequence ID" value="OAD65310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283350.1">
        <property type="nucleotide sequence ID" value="XM_018437695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163CSK4"/>
    <dbReference type="GeneID" id="28998601"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176230"/>
    <dbReference type="InParanoid" id="A0A163CSK4"/>
    <dbReference type="OrthoDB" id="2431110at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="51401" checksum="2161DAE3767C3EB6" modified="2016-07-06" version="1">MSVAGLKSLAGFEALTSGVKKCVACSKCHAIYDNEAAPLCCISPNFGKTSLCGNSLFKSDPGSKAPKKTYAVEKVVLPPDYMSLGTKIAKGFPYMKADEWKSWCLVYSLVVLRDVLPLPEFKNWIEFINACRYFTKPSVSEEDIEKGHKCLEEFCKGCETLYDLDLLSPSMHLHLHLRQTMIDFGPVYGYWLFSFERYNSVLKNIKTNRRNGFKSTFMRQFIEESWRGDYVRRLLKPMHALASSQNLSMTIRGNEPLPPYALPLKTRPLSFMPKHEYDCLVGYYQAAYKNPQISGCKNVIDDSPFVNDWIEMVKSVDLLGQSYKGCIGTNGHGSYIQAYLTEQTGSEHAYVGEIQYLFVHNFRPTVSSLTYGNSHSSQHVFAFVKWFKSTSDKTRELEEVELLQDEFYKQDFQSILPVHRILLTVAIVDYKTTKNVNKKLAIPLPKKNYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163CSR3</accession>
    <name>A0A163CSR3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ndc10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_153601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441029">
        <property type="protein sequence ID" value="OAD65350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283390.1">
        <property type="nucleotide sequence ID" value="XM_018433203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163CSR3"/>
    <dbReference type="STRING" id="763407.A0A163CSR3"/>
    <dbReference type="GeneID" id="28994109"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153601"/>
    <dbReference type="InParanoid" id="A0A163CSR3"/>
    <dbReference type="OrthoDB" id="2409254at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.20">
        <property type="entry name" value="Centromere DNA-binding protein complex CBF3 subunit, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038279">
        <property type="entry name" value="Ndc10_dom2_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="55379" checksum="916A357711B7D40F" modified="2016-07-06" version="1">MLVENSTAESSSSANLSTSVGSNVFVALQSSSSINVSEFELALKALPMKVHASTAAIYRMPLEHWKYPYTVGPTEFVIASFKEFVFKQTYIKSVSVETDVRTQIGLRTEDNKERQLTLLQSREVGWPSSKKTKEAIELLKYKHDLVYDKVQTNIDRAAHYVIRDSYKSGKLIRVLKSLWTSDSKSGLCEMFSISSCHHILLRDQDLRNLNFAYCFCTIIPKKQHKEMQQALALVFSLDKGKTLKEGKVKFACAICHENVFRCPFGAFAFFMFSLLQKTAKKALADEEIYTTQVIHGGRHAGSMEAEGLRISFDLIKQEGGWKDRLGRLETHYLGKLPSPFARGMAGFWEKPFSLARNGVSLPMELQKMKEMNEVDKNEDEDENIINLEIDEKADSVEFVEEDGRLQRIILQDAAIYLYLNKENKHIHTRNLPFSSNSFRMFQEDIIAAITSPSIGRLEEYKSLVPNIVNMNKEVANRVTEVNHRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163CUP1</accession>
    <name>A0A163CUP1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PDH complex E3BP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_119848</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441008">
        <property type="protein sequence ID" value="OAD65710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283750.1">
        <property type="nucleotide sequence ID" value="XM_018428713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163CUP1"/>
    <dbReference type="STRING" id="763407.A0A163CUP1"/>
    <dbReference type="GeneID" id="28989619"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_119848"/>
    <dbReference type="InParanoid" id="A0A163CUP1"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF82">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE COMPLEX PROTEIN X COMPONENT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="10"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="6">
        <location>
            <begin position="141"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD65710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="207" mass="22093" checksum="B3929EE5912E5489" modified="2016-07-06" version="1">MHTSAVRGAITRFNLPAMSPTMTEGVIHKWMKKEGESFTAGEVLIELETDKAQIDVEAQDDGVLAKIILKEGQKAPVNTLIGLLAEESDDISNVQIPESEDAPAKAEEAAPVPPPTQTKQPEAPTKSIDHGAIDTKQLKKPLSPAVLSLVLKHHITDVSAIKATGPGGRILKGDVLAHIGQIAFRPAPKFNNSAAPPRDQIVFAKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163CXW4</accession>
    <name>A0A163CXW4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peptide hydrolase</fullName>
            <ecNumber evidence="13">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHYBLDRAFT_79948</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in vacuolar sorting and osmoregulation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the peptidase M28 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="13"/>
    <dbReference type="EMBL" id="KV441003">
        <property type="protein sequence ID" value="OAD66400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284440.1">
        <property type="nucleotide sequence ID" value="XM_018443530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163CXW4"/>
    <dbReference type="FunCoup" id="A0A163CXW4">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163CXW4"/>
    <dbReference type="GeneID" id="29004435"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_79948"/>
    <dbReference type="InParanoid" id="A0A163CXW4"/>
    <dbReference type="OrthoDB" id="76293at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF58">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 13" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <keyword evidence="9 13" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="545"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="15">
        <location>
            <begin position="141"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAD66400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="851" mass="94381" checksum="DFE13FA53CCE1101" modified="2016-07-06" version="1">MSDTENSSLLPRPVKLTSGHYRTAKLYGIVSLGFFLFAYIIQSIRTTLPTVLVDKDAIATDGFAGMHAYDTYLSQFTEPHSMNSHEFNRLNHWLGSLALEFQTEGRARGLSVDVVVNDTMFLVANSYFVAKDEHWFVASRNILVRIQGKSNTDDAILINAHYDSVPTSAGVTDNGISVAVTLELLRYFMDHPPQHSLIFLFNAFEEGGLLGAKSFVKHPWYPSVKAFVNLEGAGAGGRAIIFRSSSLYALRSLASSGVHFVHASPLGNDMFKTKLLKSDTDYTIFTQNGKPGVDIAFYYPRSHYHTTRDDLAHITPEAVQYMGEVALHTVRGMDAADGLTQKIKRTKEEDEEDRQMVYFDILGRFLFVYTFSTYQILNFIGLLGFPAAVLGWAVYTKRSSAAHLSLYTKTLSQSILATLVGLLGVMVCFGLAVCILMAVNPLVTYGNIYFVALYILVACVLGLVLSQALLTRISPPLRVALNNPNIGLLGLTSLWWLFTALSIYLGTLRLSFMFFFIFILASSAVSFGLYHFLPRRNSWRLPSVLLSQILVPSIILVESWYLTMDSMRHATVDGTPEVAVYVLVGLPIILLVMHFLPWIHVAENKNSSAIVLGVFFVFLFTICSALQPFNAGWSPNKLVFNQFYNTTQATSSVQIVSAAGLQNTLTRTLDPNELISLECKPHLTYQTKCTYTTTNDSAATAAAVGTSSKHLPEFGSDPAEFDWTAETVCTDESCTIEGVFTAKNSMHCRIMFEDHKNQPTNITQAWVNNHYVKDTEIRTLVSYTGVFGAPVAWGATYPANQTSLPVTLGCFYDEWTEGQIPAFSSLRDRLPQSAVLLIRGQGLVLVEFARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163D1N8</accession>
    <name>A0A163D1N8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_150733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018432540.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28993446"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150733"/>
    <dbReference type="InParanoid" id="A0A163D1N8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="114" mass="12761" checksum="91514EBD777B28F8" modified="2016-07-06" version="1">MFFYMTKEVLEWWQTNGKHPFIQPHISSPSNVGANSPENLPLGDKVQLIRLPVASPSAVKEFSQVSSEEPAHLTTETMPHDFSELTELASNNFHFPMLVAWKNLPATVARDASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DFB2</accession>
    <name>A0A163DFB2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ssk1 response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SSK1</name>
        <name evidence="5" type="ORF">PHYBLDRAFT_159487</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288900.1">
        <property type="nucleotide sequence ID" value="XM_018433993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DFB2"/>
    <dbReference type="STRING" id="763407.A0A163DFB2"/>
    <dbReference type="GeneID" id="28994899"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159487"/>
    <dbReference type="InParanoid" id="A0A163DFB2"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF28">
        <property type="entry name" value="PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="75"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD70860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="210" mass="22981" checksum="FDFDE0DE68406C88" modified="2016-07-06" version="1">MILPPSPLPDDIGPEAIKISHRRTPSSLGFSLSLPSPPVTPFAPPFNLYSSSTPPAQTPRPSAESSKTATVIPARVLMIDDNPINLQILARLLKIYMSHAIGHMETADNGIKALKILAHHPFDLVLMDIDMPIMNGIDTTHHIRHPTHHPILPSNRGTPIVAVTTNDSAEWQRTYTRIGMNGCIGKPISPSALRETLNCVLELDRPHFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DFI9</accession>
    <name>A0A163DFI9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHYBLDRAFT_114945</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288930.1">
        <property type="nucleotide sequence ID" value="XM_018428428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DFI9"/>
    <dbReference type="FunCoup" id="A0A163DFI9">
        <property type="interactions" value="376"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163DFI9"/>
    <dbReference type="GeneID" id="28989334"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_114945"/>
    <dbReference type="InParanoid" id="A0A163DFI9"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13279">
        <property type="entry name" value="PH_Cla4_Ste20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000139">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000705">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="3"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="14">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="311"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="190"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAD70890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="583" mass="65398" checksum="9C6907EB38C7037E" modified="2016-07-06" version="1">MTEILQAGYLSVKEDGLRAWIWSKRYCVLRDQALTFHRNEQSGQCVALIFLKEITSVTRTDLKPYCFEVTNKDKTYYIACKNDEELYSWMDEIYNRSPVGASGPTNFVHEVHVGFDPITGAFTGLPDQWTKLLKGSAITAEDAAKNPQAVLDVLEFYTEQTKREAEEYGSSHLQGAVERRSDDRWAALIQEKQPTSPTSAANYRPIPRPAPAPPSQTYPERDVNDMMDELSVSQSDRTQSSRLTPPCTPNPLEISPRLNPNDRAPSSPVKKTAAQVSSKKKVEQRISTMTEAQIMDKLRSVVTRGDPTDMYKKLKRVGQGASGSVYVAISLSTNTKVAIKQMDLAHQPRKELIVNEILVMKESQHPNIVNFLDSFLVKNAELWVIMEYMEGGALTDVIDNNTMTEQQIATVCLESTAGLHHLHSQNIIHRDIKSDNILLNAHGQVKISDFGFCAKLTDQRNKRATMVGTPYWMAPEVVKQKEYGAKVDIWSLGIMAIEMIENEPPYLDEEPLKALYLIATNGTPTLKAPERLSRELKSFLAVCLCVDVRSRATSAELIEHDFLKKAGPLEILAPLLKFKAGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DH25</accession>
    <name>A0A163DH25_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_187705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289230.1">
        <property type="nucleotide sequence ID" value="XM_018439414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DH25"/>
    <dbReference type="STRING" id="763407.A0A163DH25"/>
    <dbReference type="GeneID" id="29000320"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_187705"/>
    <dbReference type="InParanoid" id="A0A163DH25"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD71190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="65845" checksum="5D3B1D62BB04ECBB" modified="2016-07-06" version="1">MLSYLTSGKNNSNNTSEYDFLIAIDFGTTCSGFDVVNLNEPIPKIANPNDVFNKVKCCKRAWRSKCMESEMLYSPHRRALVKYGKEADEYRRKYPSYGYDYVSKVKLLLDKTIQNECRPSIPSDMTPLTIIADFLEKIYKYIKKDIYKVYPKYYTSKYRYCLTVPTMWTDESRDLMRKAAVKAGLISEHDEPDRLFIVDEAVAAALYAERNTSGPKLTDGQSYMICDAGGGTVDIAVFEKNVLSEKTCYKEITIGTGRSCGSTFLDGRFKALMEDNLYRYPEYSEEDIEPALYKFTNNIKKRLSDPVSKFEPETREMRNDKHNGPTFAGEFSYDEIREEVFDPVVREVLEIIEKQFSQLGERRLDVMFITGGFGSSPYLQHRIKETFKDRVKHFEVVRFGTLAVMEGALLYGIDRNIVTQHASRRTYGIMLCTPSQAFSNPGPSKCKFDVCITKGDPILKDKWISKELNLENNQYSTMSVFAYDGDDPIPEYPTEEEVNPVAIYNIGFKFGDGESGLNKNLEIKMRFGLDRVEVKAAVAAKAFRYKTLLDVSGEITELPFLNPEPVIVDTSSDFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DNF0</accession>
    <name>A0A163DNF0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_78074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290570.1">
        <property type="nucleotide sequence ID" value="XM_018443329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DNF0"/>
    <dbReference type="GeneID" id="29004234"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_78074"/>
    <dbReference type="InParanoid" id="A0A163DNF0"/>
    <dbReference type="OrthoDB" id="8757000at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF95">
        <property type="entry name" value="F-BOX PROTEIN YLR352W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="612" mass="71026" checksum="658830E3B5062F50" modified="2016-07-06" version="1">MLLSELPFEILSKIADILINEDKASCTLVCKRWKFPFQDSLWKNIEVKSMEQLTSICDIVKHSTNGLSFSLAIQNLYFTSWCTITDLLQSNILQVLPNLKHLNLGDISFKTFDTEISIYGGPWKSLVSLEFQVCSTREETSQSILVEFLTQFPNLHDLNIFPCFPHTSIYFDVGNINTIHKYLSRLRSIKGAFTFPTICQSDIQTIPKAIPAYSLTSLDIHILNLNSLWLYYQWLWYFSYKYPNLRTLTLKALCETDESIIKEYNIKKGSLLRPATTLFPHLETVEFNTEDFTKWSHTVLWDLLCQSNAPIKNLRCWARYRTYEEGALEKVIRQLVQSFSKTLETMSVEGYLFFGTENIVKLEISYCPRLVELEITDNGSYIELDNLLDNCIALSRLKFSNGKLNIGSDPHEKPAYHGLNILELSYVTVNTAVFSYLSFRCRSLEYMYLNRPKICDSISDETKRLYIDMSYTNFKVLRLDHIYCYSSDRLMDKNTAINLILLSQVNSDRLSNGTRQSEDIVSVVKHLSWFHVFYGLNHTFDSAPKVRKLSEQEVCITTEYYQNFRFRESTGIQESMRSMNGQTLKSNWKADLCRGYAEMRCGNIKNYCVPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DP42</accession>
    <name>A0A163DP42_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_73370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290680.1">
        <property type="nucleotide sequence ID" value="XM_018442842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DP42"/>
    <dbReference type="GeneID" id="29003748"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73370"/>
    <dbReference type="InParanoid" id="A0A163DP42"/>
    <dbReference type="OrthoDB" id="3234349at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="147" mass="16482" checksum="06711D3C7E46D2E8" modified="2016-07-06" version="1">MVFIYSLLRKYRGTKFPQPQTELLDEANEAFVNHTHYLMLTLNVNWVNLFEGRTYAGGALYLLISNFFRENQMKAENIILFGVMPGPKEAENNQMGNFLENLVDELVELYGGITAKATEFPSGTAVHTAIMRVTSNIPAARNAAGFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DPU1</accession>
    <name>A0A163DPU1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_113185</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290800.1">
        <property type="nucleotide sequence ID" value="XM_018428332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DPU1"/>
    <dbReference type="STRING" id="763407.A0A163DPU1"/>
    <dbReference type="GeneID" id="28989238"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_113185"/>
    <dbReference type="InParanoid" id="A0A163DPU1"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000006">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00766">
        <property type="entry name" value="THF_DHG_CYH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="8">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="9">
        <location>
            <begin position="142"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD72760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="329" mass="35934" checksum="B528A57480F3925B" modified="2016-07-06" version="1">MPKILDGKALANEVRKRVKENIKSTQAKVPDYKPRLAVVQVGTREDSSVYLRMKQRAAKETGIGFTLEQLPESISEQELLNRVRELNEDSKVHGMIVQMPLPPHINETTVIEAIDYHKDVDGFHALNVGKMAKRSTTPLFLPCTPKGIIELLKANKISLSGKNAVVVGRSDIVGFPVAALLSAEDATVTICHSKTENIKSVINKADVLVVAIGQPEFIKGEWIKPGAVVIDVGINSVTDTSKASGKRLVGDVEYETASKVAGAITPVPGGVGPMTVAMLMENTMISANRALEHRNECQTVCEERLQPLFSFNLFSKKFLISTSKEVHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163E0E6</accession>
    <name>A0A163E0E6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_144985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292590.1">
        <property type="nucleotide sequence ID" value="XM_018431335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163E0E6"/>
    <dbReference type="GeneID" id="28992241"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144985"/>
    <dbReference type="InParanoid" id="A0A163E0E6"/>
    <dbReference type="OrthoDB" id="2443300at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="58897" checksum="06325388AE6B5C16" modified="2016-07-06" version="1">MSTPDPLSKDDNHSGTWHGVHPSSIRAPQQIAKPNKTLYLFTSLGCEALLSQDAVAAARACTIHPTNFSSDVNVVKINLYNIPACEATNLRKPLKAAMTLYGKVIYIHAYTDHHGQFCDEAAADRSILPWTFVPRSCPPSAATVAWKATESRPAPFALPIVVAVAKLAAAKAHAAAKKDDANEGQEANLSAEDNTTLPQPPATPVTGANIKDDAMIPDVETPDASAANSTTALTATTIKDSWIKTKIVSGDIDVIMGDPTGTSTNSTQQHIISMNEGSIHIGTLNIRGLVSTLSTPSSPKSLLCCYLRSLCPPLSLLALQETHTFPEHKQSLNILFQTQSSLWTKHCGLVSFNLLLLLTLLSVLNDERVLSVLVSHSYNCIDPFILVIMYDAITAPNALLLPTFYNGHQYTYIDFIFRSPALTTTSPEIIFLNLTWTDHSLLTISLTLQRPSGRGAVDYLDATESAASQWDMLKQVIKNFMMAYAKQFVCWCKTVEHSLCSEWQRLLCNPLLPGLTKTEARITQLQESKTANLAQRASVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167J7F8</accession>
    <name>A0A167J7F8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 ubiquitin ligase complex SCF subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_72482</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441028">
        <property type="protein sequence ID" value="OAD65377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283417.1">
        <property type="nucleotide sequence ID" value="XM_018442660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167J7F8"/>
    <dbReference type="STRING" id="763407.A0A167J7F8"/>
    <dbReference type="GeneID" id="29003566"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_72482"/>
    <dbReference type="InParanoid" id="A0A167J7F8"/>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="5"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="4">
        <location>
            <begin position="93"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD65377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="141" mass="16506" checksum="C7AF571A4E2F5988" modified="2016-07-06" version="1">MGACLLSSDNELFNVDKEIAERSILIKNKLEEMEESDATIPLPSVTAKTLQKVIEWCEHHREDPVTQDSQERRNTDIEEWDEKLPDYLKIELLLSICCKTVANMIRGRNAEDMMRIFDIPNNFTPQELVLINRENEWAEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167J9Z3</accession>
    <name>A0A167J9Z3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_70692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441009">
        <property type="protein sequence ID" value="OAD65576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283616.1">
        <property type="nucleotide sequence ID" value="XM_018442319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167J9Z3"/>
    <dbReference type="GeneID" id="29003225"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70692"/>
    <dbReference type="InParanoid" id="A0A167J9Z3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="299" mass="33258" checksum="EEF191196FE4285B" modified="2016-07-06" version="1">MLLVPSVQVKHQGSDQSPWLSVSIPSRSSFKVQVKVHGFQIKVHGFQVYQTSMSSYSFVFVYLNYPFHPGQASRFKSRSTVSVSIPSRSSFKVQVKVHGFQCSAIDIRRQGCDLPAKCSIIQVNQQYSDLPSMCSANHVKRPGSHLPAMVIDCSVIQVKHLGSDRQSMVKAIQVKHQGSTRPSMVCSVIHVKHQGSDHPSMHPEIQVKRQGPDHPSMVISIKQHYGHILTSCNILLVFSRPDLIYLQSPAIQVKHQDSDLPAMVIGITKIDEQSHSALFISSVESTKIMLHGSGFSPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JRN9</accession>
    <name>A0A167JRN9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Helix-loop-helix DNA-binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_152369</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441002">
        <property type="protein sequence ID" value="OAD66569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284609.1">
        <property type="nucleotide sequence ID" value="XM_018432893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JRN9"/>
    <dbReference type="STRING" id="763407.A0A167JRN9"/>
    <dbReference type="GeneID" id="28993799"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152369"/>
    <dbReference type="InParanoid" id="A0A167JRN9"/>
    <dbReference type="OrthoDB" id="5344169at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="457"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="175"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="550"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD66569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="596" mass="66327" checksum="942320EF0A4CCA06" modified="2016-07-06" version="1">MDFGNFDLDNSGGTFKPNFGLENNICNNNQTIDNSGDFFSFIDASTDNVNHCQATQSGNSTHQQNEIGYNIPQLTPDGREDAYTSSSVLTGYNPEYAMSPLQIATQSSSAPLLPVYHTPLGRTTLNGLEDYGDEEEFFTPLVSPAMLPTYNSHTQMRVQENTVFSPLTSPALHPSSQHAFAMNSDGHFHRPSSESLLQQKLAQIEQQQQQLRSAHQQQTQGQGSNLAAYPSPRASFTHESPSIRPIPAKTQSLRRKIALSSPQINATNTIQSPHLHPVSHNQQEHIPYSASAYSPRLNPQPSKEASFIAPATPSLLMRLGGGSNLSSGITSNTPTSAVDNMPSLPAPLLEDSVKKATKRRRISEATSFSCSPRQTATDSSTLSPMGLRPQLVTASPRALKPLISPSLQPNGKRMSLIDEEAAVALLATKSNYMHLKEGKAKSLGIEFSTNIQSGIENRRTAHKAAEQKRRDTLKQSFDSLREEIAEAMVEEEKVAEEEARYQKEKEVKQMSKVVLLQHSYEYILRLKSDSRRKDNKMTRLQKEVQALRAKLGLPEKTVEEEEEEEREKIEEEERREARRKRLESLTSEDQGQTDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KA28</accession>
    <name>A0A167KA28_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Plasma membrane ATPase</fullName>
            <ecNumber evidence="11">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_183571</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="11"/>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285615.1">
        <property type="nucleotide sequence ID" value="XM_018438794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KA28"/>
    <dbReference type="FunCoup" id="A0A167KA28">
        <property type="interactions" value="212"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167KA28"/>
    <dbReference type="GeneID" id="28999700"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_183571"/>
    <dbReference type="InParanoid" id="A0A167KA28"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02076">
        <property type="entry name" value="P-type_ATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000042">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000006">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="653"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="679"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="719"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="751"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="782"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="815"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="12">
        <location>
            <begin position="20"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD67575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="903" mass="98267" checksum="B9F0317523D4B883" modified="2016-07-06" version="1">MSVIEKSGSVQYEHQVHVQHEDDISPELAALILTDPSTGLSSSEVAERQEQFGRNELPEPKSNRLLKFFGYFTGPISYLIEISCIIAAVVGDWIDFGIILGLLLVNAVIGYIEESKAESALDALRHTLALKTRCWRDSELREVDVSELVPGDVIVLRIGDIVPADACLLGMGVNGEKNEGELMIDQSGLTGESLPVAKVKGNTVYSSSIIKQGQQLAVVTKTGNNTFIGRAANLIAITVEEGHFQKVIGKIGSVLIWSTVVLVSIVFVFQMVKYNGTPQGNWKMVLENCLVLTVAAIPVGLPTVMSVTMAIGAKQLAAKQVIVKRLTAVEELASVSVLCSDKTGTLTLNELTFDDPWLTNGYTSDDILLYSFLAAETGANDPIESAVRRAAEANLPILQNRSDKRGIPGYKVTAFLPFNPDTKMTQATILDLTTQQTFCVAKGAPQVITKLVGGDNAAVHAVNSLARRGLRALGVARTVPGSATMSDFELVGMISLLDPPRPDSAETIAACNRLGVDVKMITGDQQIIAREVAARLGMGRVILDAGHLVDPSKTEEEVTEHCQRADGFAQVIPEHKYRVVELLQNKGLLVGMTGDGVNDAPALKKANVGIAVEGCTDAARSAADIVLLAPGLSTITDGIITSRAIFQRLRSYALYRITSTIHFLLFMFIITLVEGWRMPAVLLIMICVLNDAATLVIAVDNTEISERPDKWRIGQLMTLSIVLAVLLAGLSFATFYVARDVFHVTPNELHSIMYLHISSAPHFVIFSTRVPGFWWENMPHWLFFVCIIGTQIIALFFSVYGVFGEAEGVAPCGYGWGLSVLGISLVYFMILDVVKVYIFRFWTFELTAKLVPTQARLAKLTKRKADAEKEKHVAALWGKMGRAIEAHTIVTAFQNLDQEKILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KGX5</accession>
    <name>A0A167KGX5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_188799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286109.1">
        <property type="nucleotide sequence ID" value="XM_018439563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KGX5"/>
    <dbReference type="STRING" id="763407.A0A167KGX5"/>
    <dbReference type="GeneID" id="29000469"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_188799"/>
    <dbReference type="InParanoid" id="A0A167KGX5"/>
    <dbReference type="OrthoDB" id="10267139at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="entry name" value="CofD-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240:SF0">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="CofD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="535" mass="58797" checksum="ED64723800A27FFB" modified="2016-07-06" version="1">MILEIDDETISFKVLRLAVISPTLHRQWHMKYTIKSPSFVIFSGGSACNHIIRAFHESPGQDVSYVLGVSDNGGSTSELLRVLGGPSIGDLRSRLLKMMDLVSDQPCVERTAIKELLSYRLPSNIPDHLVKDEWTSIVEGRHTQKETIRGFLTLFNFEILKRAHKQFNFCNGSIGNFFLTGARLFLGSLEAAIFLLSAITGIQSDRASIVPVINTNHTVTIAALLADGGTLVGQCEISHPPNNPAPDTPGGRRKKYRTNPIDAFSCLSEEEEMYRMNVANTNLVFSKFADEKLESPIKRIFYMNDYGQEIYPIPNPKVISQLSTKETLVYSIGSLYTSVLPCLVLRHVGNAIAQSSSLKHKILLLNGSNDRETSDYSALDFISAITNGLNESKKIDCRRAFYQSCDEEPDLLLESPLVLPSSSYCSVSSSSSSNSTTSSCGTISPGCSPRQGSGSGSFEQAEYPPFPNHLFYPSPPSAFITHLVYLDNSTIPVDKIAIQKLGIQPICIRGTLSGTGEPVYDETAVSNIIRRIVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KS37</accession>
    <name>A0A167KS37_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_173163</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286788.1">
        <property type="nucleotide sequence ID" value="XM_018436957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KS37"/>
    <dbReference type="GeneID" id="28997863"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_173163"/>
    <dbReference type="InParanoid" id="A0A167KS37"/>
    <dbReference type="OrthoDB" id="2262863at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF34">
        <property type="entry name" value="NOTOCHORD-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="825"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="828"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD68748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="953" mass="108690" checksum="E720B45EB2386BBC" modified="2016-07-06" version="1">MQKNTRQETYKIVKTCPPKRQGELNFSINSGVFTCSECKKEFEKPWLLKRHSKVHHISNQMATNTVLDKPEQAELIVENTIPDANAFDYLSDEDDSSSIRDEEDNIVDEENDIVDNFFDIEMNSNPVFNAFSDMFSSAAAADEVSMTDNDSEIPEEVFGTIGAINDPTSCYPFCNLQTMILFAFIDGDNDMISQLMLKKILLAMNLIIKIQQETPIERTFKLSRFDALLNYQARKKFKMPVFSSQRISVPGSNGNAFAHINLPSDHLRFLMANPKKSKLISSMPNHTPNQSICLEQGKKWRTHHLFQQSMHTVNGIDIWFGNIVYLKTNNCSICFLVELFHMANKNIFARGYLVRAILIVCYDVEVAVADLRVEQISHVDTTPVERDHYYSISSSLTRLSPAHDFLLFGVHPMKKSMPLSVLPSNVDRDAVFYKVRIVSIILFTDDTSGNHSKQYNPFESWLMRCTALPFKDRNSIANIQFLSTIPKKDGANDKKYVLVVAPILWIETDMSCHLELCGLLGLATTFPCRRCYIELRCAKDFVKDLSYFCECHERQTREHYVLANSSPGRDTEISNALKIGMNMPANKISFRDHSTGHLLELQSFDPEKNTLVEILHTILLGVAKYMVIDLVKVVLKNDIATIARLLEFLTDYTRSTGLSRKFTRNLRHSGSFLGRDFKVLLQILSVILITEFSGNHELDLVISCFVELGQLCSLVVVRQVTSDFDNYIIRVDNAVKHLIRALFDYNKGTKNELHKAYCTKLKVHYLTHLKEDIIRFGPALNYETEKGEQFNKHICEHLFYTNCQNTSRNVCLKLAKQVALQHFNSSGNREKSGTGIESSRELKDNNDTGDIEDDAVQNNSFGAFVFKDDPISHPRIGLVSGSVVKFPSIVPHTDNDRNNNYAKAVMTGEHSDVANMNLVCKLDLHIFRNLFYIVNLSKFGSYWFIFNNILFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KTV1</accession>
    <name>A0A167KTV1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHYBLDRAFT_116715</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286909.1">
        <property type="nucleotide sequence ID" value="XM_018428536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KTV1"/>
    <dbReference type="FunCoup" id="A0A167KTV1">
        <property type="interactions" value="985"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167KTV1"/>
    <dbReference type="GeneID" id="28989442"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_116715"/>
    <dbReference type="InParanoid" id="A0A167KTV1"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17953">
        <property type="entry name" value="DEADc_DDX46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22475">
        <property type="entry name" value="KH-I_AtRH42_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="166"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="355"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="25"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAD68869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="801" mass="88058" checksum="FBD004032D6824A5" modified="2016-07-06" version="1">MGGAEEVDPLEAYMMDVTAEARKINEEDKKRLQEIGKSENKRTNEEDEADFEPSAAAEEDMGSDPEDILALAAKKVKRKDLAPVDHSQMEYEPFRKNFYIEPPELKEMTSDQVDMLRIELDGIKIRGVNCPKPVLKWTHCGLPAGCLEVIRKLKFDKPTSIQAQAVPAIMNGRDVIGVAKTGSGKTIAFLLPMFRHIKDQRPLEIGEGPIAIIMTPTRELATQIHRECKPFLKVLGLRAVCAYGGSPIKDQIADLKRGCEIIVCTPGRMIDLLCANSGRVTNLRRVTYMVLDEADRMFDMGFEPQVMKIVNNVRPGRQTVLFSATFPRQMEALARKVLKKPLEITVGGRSVVCDDVEQIVEVREDSTKFIRLLEIFGQFFNTEETEDSRALIFVDRQEAADNLLRDLIRRGYLCQSLHGGKDQADRDSTIADFKSGVCNILIATSVAARGLDVKQLKLVVNYECPNHMEDYVHRVGRTGRAGNKGTAYTFITPDQERYAVDILKALRLSGQSIPPDVQMLADRFQEKVHTGKERMASSGFGGKGLERFDKDRDMVKKIQKKAYGGDDLEESDEEDIELETRVVSNGGSGSNNIGLGKKDDSGHMSNVPNIPGQAAAAAAAAAANAAEQGKGSNEQLSAAALAAKRAATEVAARINAMVGSKSRTAHDVVADINARFNVSTTGGGPPQVEEKKDEGNPVYAEEIVINDYPQKARWRVTNKEQISQITEISGAAITTRGTFFPPGKQPGPGDRKLYLFIEGDSETVVDRAKNEIKRILIEATVAQMEAEARTGGGTAGRYSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KVS4</accession>
    <name>A0A167KVS4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_172841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD69007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287047.1">
        <property type="nucleotide sequence ID" value="XM_018436882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KVS4"/>
    <dbReference type="GeneID" id="28997788"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172841"/>
    <dbReference type="InParanoid" id="A0A167KVS4"/>
    <dbReference type="OrthoDB" id="2393464at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="149" mass="16918" checksum="CACAAA3FEE858BBD" modified="2016-07-06" version="1">MSQEQEVTEKPKRKELSDYEKGIIVGMYMRIPKMSSIAKDLDIPYTTISSTIHRWKTTGTAQTKKRPGRPETLTERNKCAIQIALLRNPNISLQELTESIQKKVSARIGVNVVRKAIKEVKRRTLGALNEQPLDTELTTQSLLVGKNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L4L7</accession>
    <name>A0A167L4L7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA repair protein REV1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_116209</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287627.1">
        <property type="nucleotide sequence ID" value="XM_018428509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L4L7"/>
    <dbReference type="STRING" id="763407.A0A167L4L7"/>
    <dbReference type="GeneID" id="28989415"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_116209"/>
    <dbReference type="InParanoid" id="A0A167L4L7"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000001">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="13">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD69587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="258" mass="28539" checksum="80756977F6161BB8" modified="2016-07-06" version="1" fragment="single">ADEIQAVSVDEALLEVASHVTQPGTGQEMDLATQIRDKIRSKTGCNTSVGVGPNILIARLANRRAKPNGQYICGLDQIQDLLSSIEVTDLPGVRKTTYPLPRYLKGVRIVKDLALVPLSNLQANFGTKIGQTLHNFSKGIDDRLLSTHPTRQSVSAEVNWGIRFENEEKAKTFIDDLAKEVSERLDSQQMKGRSITLKIMRRKLGSGAPLKYLGYGDCDTFSRSTVLPRATDDNQVIAKNAWNLYKQLNFTPSDVRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L6I3</accession>
    <name>A0A167L6I3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_172337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287745.1">
        <property type="nucleotide sequence ID" value="XM_018436773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L6I3"/>
    <dbReference type="FunCoup" id="A0A167L6I3">
        <property type="interactions" value="674"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167L6I3"/>
    <dbReference type="GeneID" id="28997679"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172337"/>
    <dbReference type="InParanoid" id="A0A167L6I3"/>
    <dbReference type="OrthoDB" id="1432093at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051181">
        <property type="entry name" value="CAF1_poly(A)_ribonucleases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092">
        <property type="entry name" value="POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092:SF22">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE PNLDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="554"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="601"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD69705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="619" mass="71222" checksum="7F8211EF6BA55FCF" modified="2016-07-06" version="1">MEVLKQNFEELYPIVKEAILEADFISIDTEFTGLTPPGVSFQQFDNMQQRYEKLAQCIREYTIVQYGVCAFKKTENGYTAKPFNFYVFGCDTNDLQARRTFSCSASSLSFLRSNKFDFNKLIDGGIPFYNFSEEDSAIQSASGTTFAHRNIHQGRESTHPGSIAFLDTLRRNLGKWLQNSSNKPLVVNVNKPVHRKLVYQEMAKAEYNSFLQASHRDSKNMEISRITVEERQRRQRALSPLLNFRNIIELIKDAKCPVIAHNAVFDLFHTVDQFWRYLPQEVSDFKKTLNDMWETVVDTKYMAEFHPDLKKCFNSSVLASLYNTVEEEIKDGGPTVTLAKGYGGYHEEGAATLAHEAGYDAYMTGVIYLGFVYYIHERERERLESEDDKTKNSKKSNKKIKTDSNVDKNQKKSGKDETFMDKSLLPYYNKLFLMRSDLLYMDLKGVEEYEPIDHPNRFYLNNVPSELTFSGIEQIYPEIQPAHVTWTPDNNAWINIKHDNKVELVKLGPLGEDRIRDFLPGGSREAEGVASGITKEASKIEILTFKQWMELQNPKKEDEDKNQAFDESNNATRDFVPTGGSSYDDLDIPIPPSFASAKKRPHEDGNEPNENHNKRHHPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LKH0</accession>
    <name>A0A167LKH0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lactate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_148565</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288688.1">
        <property type="nucleotide sequence ID" value="XM_018432109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LKH0"/>
    <dbReference type="STRING" id="763407.A0A167LKH0"/>
    <dbReference type="GeneID" id="28993015"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148565"/>
    <dbReference type="InParanoid" id="A0A167LKH0"/>
    <dbReference type="OrthoDB" id="2266445at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015129">
        <property type="term" value="F:lactate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015295">
        <property type="term" value="F:solute:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003804">
        <property type="entry name" value="Lactate_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30003:SF0">
        <property type="entry name" value="GLYCOLATE PERMEASE GLCA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30003">
        <property type="entry name" value="L-LACTATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02652">
        <property type="entry name" value="Lactate_perm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD70648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="66547" checksum="38D61DA3D1A7E81B" modified="2016-07-06" version="1">MVAFDIPEIPAYVYEQNMFIQELSPIGGSLVGSFFVGLIPLLLVLVLLGVFRVPAYIASFCGLIICIFISIFAWHMPAQQAFQAIGNGIVFANWPIMWIVVNAMFIYNVSVESGIFDIFRRWMITNTPPDTRILLLIVGFSFGALLEGVAGFGTPGAICSSLMVSLGFEPADALVFTLIFDTTPVAFGALGIPVTTLASLTGLDVMDLSAMMGRQLPLLSLFLPLYALGFYAGFRAGIMECWPAAAVAGISFSVIQAVFANLVGPELPDLIAGLISLLSLIIFVQFWKPPYRAEYEATVGKMRTQGDIEASAGVAPAPAENHDRPLSISSGISAAPNTTEKAVGEVNKQEIETTENVMSYVKPTFRETLLAWSPWIIIVVIVIIWSFAKVSEKGQVLVHWPQLDQRVWLTLYGKPYAAIWTFQPLATGTAILISFFPFAAIVLWYGAHPRVFYHALKATYRQLHMPVLTVSFIMAFAYLFNYSGIVYSIGLTLASVGKAFPFLSAWLGWLGCFLSGSDTSANSLFGNLQVVAAREIGLSAVLMAATNSSGAITSKMISPQNLTTGVSTIGLQGQEGRILRRTIIHSLIMVCLIGAMACVQQYGIPGIIPHYEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LN99</accession>
    <name>A0A167LN99_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="19">GATA-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">WcoA</name>
        <name evidence="19" type="ORF">PHYBLDRAFT_77612</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288826.1">
        <property type="nucleotide sequence ID" value="XM_018443280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LN99"/>
    <dbReference type="SMR" id="A0A167LN99"/>
    <dbReference type="STRING" id="763407.A0A167LN99"/>
    <dbReference type="GeneID" id="29004185"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_77612"/>
    <dbReference type="InParanoid" id="A0A167LN99"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000064">
        <property type="entry name" value="Vivid PAS protein VVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF7">
        <property type="entry name" value="GATA-FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0157">Chromophore</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="16">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="17">
        <location>
            <begin position="153"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="16">
        <location>
            <begin position="284"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="18">
        <location>
            <begin position="576"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAD70786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="624" mass="70639" checksum="816ABE1AA258DABA" modified="2016-07-06" version="1">MPQYCDISTLTLEEEPVCMPAFELFDETIAPLEVQAAPVRTPSAPIAGVYSNSGFDMIQVLSSLANRPNPEIHLGPIDLSCSFLVSDARQYDCPIIYCSPAFETLTGYSSNEILGKNCRFLQAPDGLVTGGSRRRHTDNQAVYHLKAQLIQNREHQASIINYRKGGQAFVNLITVIPLLDNQGEVAYYVGLQVDLVEQPNSIMEKMKDGTYMINYQQNPLPLQLPDKAILDQMDDYFRELPSLGSTYSFLTNPEVMALVKSKSARSRCDSENEQSYLLEWNKLILDQSDDFIHVVSLKGFFLYCSGAAKNLLEYEPEDLLGKSLSSICHPSDIVPVMREIKEAAASGNSGKVVDLLFRVRRKYSGYMWMECRGRLHMDQSKSRKCLVLSGRQRPVYKLHWRDICSTSLEGTEFWAKTSLAGLYLHVAAKCQETIGFSAESLEGASIYQYIPNHEIPDMSRAFDLVRQGQRVNLQHSILNEKGNYSTVTSTFYPGDVSSFQSEPAFALVQTRLGREEMFRTDNNLQENVFSEIEPTRGTSWQYELHQLQLANKRLHEQIESLSGPKRKKQRKRKHIQEISKMCAQCQSQDSPEWRRGPNGPKELCNACGLRYAKTIQTRPKITAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LNB5</accession>
    <name>A0A167LNB5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_64133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288828.1">
        <property type="nucleotide sequence ID" value="XM_018441241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LNB5"/>
    <dbReference type="GeneID" id="29002147"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64133"/>
    <dbReference type="InParanoid" id="A0A167LNB5"/>
    <dbReference type="OrthoDB" id="10613893at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="116" mass="13294" checksum="7099219FFF22259C" modified="2016-07-06" version="1">MIKSLKKLGVLPQSEKDVKVDMILCFFSDKKNVFTCEDKLPNPSNTYIEHLEAISTQFICRELIVLGARDENSVESLRSPWSEEAVLRNYSPGESNTDDEDDKDIQPSQKEEKKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LQF7</accession>
    <name>A0A167LQF7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_148128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288944.1">
        <property type="nucleotide sequence ID" value="XM_018432015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LQF7"/>
    <dbReference type="GeneID" id="28992921"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148128"/>
    <dbReference type="InParanoid" id="A0A167LQF7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="84" mass="9293" checksum="1E005C556C727A70" modified="2016-07-06" version="1">MVGLLPKHGGHPACYSSPCHRRILTRNLIAFTLIKRRFGDSGLTPSRAPCTMVLKLHLDTTSVCCHADIRTVLSKLTLRATPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LT81</accession>
    <name>A0A167LT81_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_72520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD71047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289087.1">
        <property type="nucleotide sequence ID" value="XM_018442670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LT81"/>
    <dbReference type="GeneID" id="29003576"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_72520"/>
    <dbReference type="InParanoid" id="A0A167LT81"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="177" mass="19148" checksum="E047F0C9143C4DA5" modified="2016-07-06" version="1">MTKRIPTAPRRPNLCMNAVLNSTIAGVVAPIDTPTPEVAVDTAPEVQVAVTPMDHFLTFLAANNVSMQSLQENAKGVTDAITHLKNGLDLSNKTNEFLKNSVLQLMTENAEIKKAMTSQNSVMPSAVPADSSSSMDDDLDLGAKHHPLISVIISRNRTLLAQTRSKLLRIIIDQHGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LV55</accession>
    <name>A0A167LV55_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protection of telomeres protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_182151</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the telombin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289198.1">
        <property type="nucleotide sequence ID" value="XM_018438576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LV55"/>
    <dbReference type="FunCoup" id="A0A167LV55">
        <property type="interactions" value="147"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167LV55"/>
    <dbReference type="GeneID" id="28999482"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_182151"/>
    <dbReference type="InParanoid" id="A0A167LV55"/>
    <dbReference type="OrthoDB" id="2186770at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000783">
        <property type="term" value="C:nuclear telomere cap complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098505">
        <property type="term" value="F:G-rich strand telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032210">
        <property type="term" value="P:regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028389">
        <property type="entry name" value="POT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032042">
        <property type="entry name" value="POT1PC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011564">
        <property type="entry name" value="Telomer_end-bd_POT1/Cdc13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513">
        <property type="entry name" value="PROTECTION OF TELOMERES 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513:SF0">
        <property type="entry name" value="PROTECTION OF TELOMERES PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02765">
        <property type="entry name" value="POT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16686">
        <property type="entry name" value="POT1PC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Telomeric single stranded DNA binding POT1/Cdc13" evidence="10">
        <location>
            <begin position="25"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Protection of telomeres protein 1 ssDNA-binding" evidence="11">
        <location>
            <begin position="245"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD71158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="517" mass="57946" checksum="D0A691CF03E4DAE4" modified="2016-07-06" version="1">MSEGINTEFTSEIKELGVIPIAEQVLARNQEVCGVISNIRDIIVPHTQRRDSSRFFTIVDPSTGTLGGRKIQSFHSQKECLPMGQVGDILICRGLTLSDFQGEVRGVLSARYFSASWTTLSIHDLKPIPEVVTDFIASPKNMAIAKVLQKWYKQTGCPLPPTPGDGSREKSVEKSKNELTYFRGKPFLTTAQIGEGLFAYCNFIGVYLGCRYANVSMTLSLTDFTVNPHTGGATKPSYGVSPDVILLCTLWDEHAENCPKLERGDYIMILNGRRKINSHGVLEISIHGDVLSPVYIQKVIKLSPDDERLDDIKARSNSANEHSKNVADPKNTGEKPSNLLYTESIELKEARSVITSPIILPLTTFLQMQTDGVAGKLYNIRGCVTDFRALDPAEWFLRWCLKCEKYSARFLKTCKSCKNPLSDLKYRFCLFLEDARGDQLYIFCIGSNIYNLFPGLPPSLALESVEMAEQLYARMLKLCPKKDDAKTYLDFRVKCIQGSGPRNLAKYALKDTKFYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167ME74</accession>
    <name>A0A167ME74_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_113606</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Cd(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48775"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290636.1">
        <property type="nucleotide sequence ID" value="XM_018428348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167ME74"/>
    <dbReference type="STRING" id="763407.A0A167ME74"/>
    <dbReference type="GeneID" id="28989254"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_113606"/>
    <dbReference type="InParanoid" id="A0A167ME74"/>
    <dbReference type="OrthoDB" id="2338at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337:SF0">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0104">Cadmium</keyword>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD72596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="477" mass="53645" checksum="0ADF546E48224D4E" modified="2016-07-06" version="1">MSSSSQTSRNEWTPESWKTKPIVQDVTYEDQEHAKRVLSKLDRLPPLVSAKEVLIDNLRQQLKEVALGNSFLLQGGDCAELFDYCSQDPIEAKLKVLLQMSLVLTWGARTSVVRIARMAGQYAKPRSKPTEMYEGKEILSFRGDNVNGFDPKDRDADPERLLGAYFHSAATLNYVRSLLDSGFADLHDPSNWNLNHVRSESVRSEYQQIVTQLTDALDFMGTIGADSRQQNNNALNSVDFFVSHEALLLDFEASLTRLLPCTIPSADNKAKKEKKWYNAGAHFLWIGDRTRQPDGAHVEYMRGIENPIGIKVGPTTKPDELVELLNTVNPDKHIGKVTLITRFGAGQVEKHLPQHIKAVKKSGHIPVWVCDPMHGNTKNATGGIKTRHFIDIIQELSEAFRVHKDNNSKLNGVHFELTGDSVTECIGGSMDLKDADLSTNYQTYCDPRLNYEQALDVAFLIGKYYQKERRGQVFPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MLQ2</accession>
    <name>A0A167MLQ2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_145619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291256.1">
        <property type="nucleotide sequence ID" value="XM_018431494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MLQ2"/>
    <dbReference type="GeneID" id="28992400"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145619"/>
    <dbReference type="InParanoid" id="A0A167MLQ2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="240" mass="26746" checksum="E1D25CF85AAD5A77" modified="2016-07-06" version="1">MAEKIKMKTTRLIAQLLGRRTSNRQIGGSNPSVGHFFQFFTKTQKFRPNSVSHSPQYHSILKHCLEAFSVIWEAHFQPIFKEVLIVNNQSFKLKGEKLLIAVAAAATAAATEKKLNTTRLIAQLLGRRTSNRQIGGSNPSVGHFCQFSPKPRNSGLTVVQIAGFRPPVSSKDKPGLQGLFRSPSLFSVVSHSPQYHNILKHCSEALSVIWEAHFQNIFKEVPIVNNRVAAIVILNIIRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MQ38</accession>
    <name>A0A167MQ38_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TRP C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_168855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291546.1">
        <property type="nucleotide sequence ID" value="XM_018435949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MQ38"/>
    <dbReference type="STRING" id="763407.A0A167MQ38"/>
    <dbReference type="GeneID" id="28996855"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168855"/>
    <dbReference type="InParanoid" id="A0A167MQ38"/>
    <dbReference type="OrthoDB" id="2115177at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF6">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007890453" description="TRP C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="30"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="530"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="TRP C-terminal" evidence="4">
        <location>
            <begin position="183"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD73506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="786" mass="87247" checksum="E4F8426F6EB563A9" modified="2016-07-06" version="1">MTVHGLSLSQQATRLVLLIFLIFTALSRGETLAHTYVDSSNFTTCPTENSFTISAVKRIYNPRLNTYTLNITGAPLIAVETINQAGEFIPAARLEIMMGFATTVNTVYSFCPDVVSGCPLSAGTSINISKSVNIPASSLPLADISARYSAWTADKVPLVCATIGSVGYQNPTWRAIFIYLPAGFTAFSALVSFVASFVTLGEADRDILLFTSNYAMLPAAVRFKTPGFFDLVFYAQFIVTTGMLNLSYPMFYPLFTANFSWSFLLFSSDWINNLMTQVFPSTSNDTERAINSSGFAFNKRQLSQPLSPEPSVIIRPQINNTGTGMVNFATAVDLDINKLFLTSLLYFLIILGGCLCICFLIWAVSTCFISQNRPNLYKNHSEKIRNFTIGISLRILTLFYLPLITTAFYQLMLDAPWYLLLTASIVLVFPLCLLYGYIGFALLHIKPTSVVFSDITLLLRYGSLYNTFTDDHVHFFVLLIVYKLFVGAMVGIFQTSGIAQLVVIILAETVLLCTLVVNYPYADRRINIQYAILSIFRITITFLNIAYIESLHVLNVTKQYIAYIQLVLHCIVYLMMFVLPVKNMVILAIGLADEELYDNTVPPARMAIWRRRWKPSSMEEAGPSTERLCREVSLPLAEPSSRPWGTVEANDHQRGTSINPDRLPTSSSSSASPPPLPTHTIFSSEYRSIPTEDTVTHTNDKPHATRSSPIGGSKRHSSNVLLSYDDPAIDQPLVQADAFLTVDNSPPSEKGSAFRNSPSHRQYKPQLSPTGSNEAPNMPPYNENNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MQ95</accession>
    <name>A0A167MQ95_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_168873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291564.1">
        <property type="nucleotide sequence ID" value="XM_018435955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MQ95"/>
    <dbReference type="GeneID" id="28996861"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168873"/>
    <dbReference type="InParanoid" id="A0A167MQ95"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="194" mass="22474" checksum="120204BBF5FF5E9B" modified="2016-07-06" version="1">MNVVMKTDDHRTVTTAGTLPQSGAIRHGSWTGRHCCEARPTLHFQSVDWRILLRVDDLNYSSTEISRLKMSVDLGFLYCEIYHIQDLNGVATKRKELDQVWKRAIEFERKIQNACAKTSAKEEVREGYIKRYGFGKKSVSICKERPSRRSGKMKRRIGWVSDQKEKKSETEVKDNEAEEHLAEIFDSKSSIRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NS07</accession>
    <name>A0A167NS07_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Decapping nuclease</fullName>
            <ecNumber evidence="6">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_142068</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="6"/>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294590.1">
        <property type="nucleotide sequence ID" value="XM_018430733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NS07"/>
    <dbReference type="FunCoup" id="A0A167NS07">
        <property type="interactions" value="276"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167NS07"/>
    <dbReference type="GeneID" id="28991639"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_142068"/>
    <dbReference type="InParanoid" id="A0A167NS07"/>
    <dbReference type="OrthoDB" id="5853397at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="8">
        <location>
            <begin position="20"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD76550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="382" mass="44324" checksum="54679B22AFCEB9BC" modified="2016-07-06" version="1">MSFPVRPPVSYKGEFPTYAQPAEITSYSIDHNRQVWFDDRELKYYYPPNGKDLYVGFDKFIKRDESIPEHIDTLLDALTNARQKASNPQLAQADIVTWRGIMTKIMCTPTTRNEPWMLRATRHKNTIYIEEQAMDEKKRNEADLPIKEQMQCYGGYRFETLCTLSKPPSKVQKGDPELLQRLNDSADTNIQYCVVVKTKLGKNSLIMGAEVDCSRDVKRVGEKSNPLQNYVELKTSRLIENSRHQSSFERFKLKKFWAQSFLVGVPRVICGFRDDQGLVQSVEEFKTMEIPRMVRNKPGLWEPVVCLRFANEFLDWLQTVVVEDDPTVTYIIEWKAPWHEITIRKESIPQPFITQRYIDGETSHEIGGPRVSSSTSSYKSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NS16</accession>
    <name>A0A167NS16_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_142072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294594.1">
        <property type="nucleotide sequence ID" value="XM_018430735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NS16"/>
    <dbReference type="GeneID" id="28991641"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_142072"/>
    <dbReference type="InParanoid" id="A0A167NS16"/>
    <dbReference type="OrthoDB" id="2275011at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="54788" checksum="604C71E39E0C556A" modified="2016-07-06" version="1">MLASDLPLEILSHLKISRHRGSWQPVFQASLWDDLHISPTNEKLFFDLLDDPQTIQQCFPNLRGFASMLRYKEDILSFMPGSWNVWTSSLRELTIASLSLGILSDKKATMKFLSQLPGLSLLNLIHYNPHQPFQFGMDEFEKLHKLLPRLSDLSLIVKPGPLSKKDLSIIDKVQPIHHFTRLNLTVFGTPYQRPFYFAYKYPNLRSLEWENSVESDMISGTWDSNIDKLFEVLPRTFGKLESVIVGTRETLALRVTHLLSYLDRAAVSAKHLNYRYLSIPAGPDPALRTTEPCITMFSTTLKRFSLTYPTCFVRVYVKKPIFEYCHCLTELNLINLDIIVELDVLFNCLPSLTRFTFYGGIFSVSQGVSNTVSNHGFLKLNLKSIRVKFDAFEYMSFHCRELRAMDLIRVKVSGHISQSTGNILLNMPYIILKSLNICNMQYFDENDAEYQFPINIMRVSQQGNSGEERRGKENPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NUW2</accession>
    <name>A0A167NUW2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_185802</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294704.1">
        <property type="nucleotide sequence ID" value="XM_018439147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NUW2"/>
    <dbReference type="GeneID" id="29000053"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_185802"/>
    <dbReference type="InParanoid" id="A0A167NUW2"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12524">
        <property type="entry name" value="RRM1_MEI2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034453">
        <property type="entry name" value="MEI2-like_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="119"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="31"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="301"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="451"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="505"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="505"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="579"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="594"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD76664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="614" mass="69091" checksum="B27921222D245F2F" modified="2016-07-06" version="1">MISQMIISMDANNVKEVLVVWGMAGEEHRGIQKPFRGGRGKNMRPEHRGMRDSEDDNYRAYNDPPQPPFVQPYGARPINEGREYRNEPWQDDAYGSSDQAPKARASQLESRAAMERPCRTLFVRNVQYTIQVSEIRETFEKFGEIKDIFDLIERRGMAFITYYDIRAAEAGKEAMQGAMLKCRMLDVHYSLPKQEEEEARCDRTKNQGTLLLTLKDTDNTINDSELSLYFRQYGEIKVIRTPHFKTHRENTELRQRIIEFYDSRACVNAFDGCHDKPYKGGRWDISFFWDHSFKERTEALAARKEQPNDKKMDGHLNGSRHGRNGGGGNGGGGGGGGGGQRRMGGGIGGQRRDDHHHHHGHHGHSHGHPHHNQRRDSSYDSIPDHNRPLHRYGSYSEESSGPIMSPKTVYDPAIPSMGGPFKPDANQERLEQAQKAQQVLSMLAQTQTVQGVPTQPAFGHPTGTYGGQANGTSTVPPLPQAPAAAQLQQILGLLGQVAMQQQQTQHQQQPLLSSQPQQVPQQQQHQHQHQHQQQQQQEHQIPPHQSHSSYQPSIQQGQQNHMTSSQASSTATPVNTSIALGQLAQLLKHAQQQPEKPSNTGTSSFYYDPYGTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NYZ7</accession>
    <name>A0A167NYZ7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_165407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294949.1">
        <property type="nucleotide sequence ID" value="XM_018435232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NYZ7"/>
    <dbReference type="STRING" id="763407.A0A167NYZ7"/>
    <dbReference type="GeneID" id="28996138"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165407"/>
    <dbReference type="InParanoid" id="A0A167NYZ7"/>
    <dbReference type="OrthoDB" id="3248986at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD76909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="75607" checksum="328F975A04365F63" modified="2016-07-06" version="1">MSNNQKKDSYVICKCPDYVPEEHFDDMEVDSIDSDNDNDYDYKNEGKGEYEDENEEQNIEFDQEVDLPLSQEESIFTAKDTITGAFVVDGNEIKEGDTSFDFEQEENFDETSGTLIVESVRPSSFDNMPLYIRFVAVFIVIFHLIFLVESGGSILIEFCNTLLSLCDMSGALPLTINSLKHKTGFNMETDGMTVYIACSQCHSIYPLETSQRVCTFKKFSQSAICNNNLFKVSTGNRSLPAMVYPFNSLNWANALNNTERTYLEKENGTRWSDLHRLSYFDPVRFTVIDPMHNLYLGTAKRMIQIWCECNYINEKNQLTIQELANGIVVPCGYARITKKIANGFSFMKADEWKSWCIIYSPFVLKHVLPAKNLENWILFVDACRLLTKPSINDKEIDEAHSKLQLFCTRFQTLYGKSAVTPNMHLHLHLGECVHDFGPIYAFWLYSFERYNGLLKNIETNQKGGFESTMMKRFLERTYIGSFIQSFVNHLPQFAIDFLHRISNSQDQLAALHPSSTASTFSLSDFVEYSLNPHHSALGCEPLPPSVFPIKLDQRITMCKGHYECLLEFYRHAYGSHDIFGHYSNCESNQIFVNNRIEKIKRISLLGQEYSSGSYFRAYYLENNSEDKAAFSGHILYLFQHLITINETVITHTFVFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P4P2</accession>
    <name>A0A167P4P2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_142741</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295279.1">
        <property type="nucleotide sequence ID" value="XM_018430859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P4P2"/>
    <dbReference type="STRING" id="763407.A0A167P4P2"/>
    <dbReference type="GeneID" id="28991765"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_142741"/>
    <dbReference type="InParanoid" id="A0A167P4P2"/>
    <dbReference type="OrthoDB" id="5877963at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PROTON/GLUTAMATE-ASPARTATE SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865:SF7">
        <property type="entry name" value="PROTON_GLUTAMATE-ASPARTATE SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="532"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD77239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="558" mass="60098" checksum="B7D65A38805BCB19" modified="2016-07-06" version="1">MPSHPILKKLGGVKTIFGGLEIPLDTVEVKKPYPKLAVKVGGAIGYAFFTFIWNPIVYTFRFLSRHTNLTEWIIFSMVVGILIGNFAPDFGVQLKPLGTAFINMITTIETPLIFSTLVVGIAGHGDDVGKVGRLAVKSIIYFEVITTFALAVGLIMANLLKPGSGVTLVGDAGVGAEYAEKQSGISWETELNLIIPKNFFVAAYENKILSIVFCAAMFSCAMMLADKKSKAVMLQVNHSLSMVMFKFVGLVMNYAPIGKTSFPFLWPENRLDQDSLSIGAGLAATVGTSGIEVLRNLGKLIGSLYAALVIFVIVILLPVMFMARVPILGFFRAIGQPWLIAFSSASSESALPKAMERMRQFGCPNSLTAFVIPCGYSFNLDGSTLYLALASIFAAQAGGMNLPIGTQLSIMGTLMLSSKGVAAIPRASLIVLAGTLSQYNLPEQAIPMIMGVDALMDMGRTSINVLGNCLGCCVMSRVEGSFRGDVWKEEEADRRQEAMDAVAAAEAKENGSINSGRSQVDEELKDIVVHTEKATSSTNHQSNHGIDVFEYESPKPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P5W0</accession>
    <name>A0A167P5W0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_179807</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295346.1">
        <property type="nucleotide sequence ID" value="XM_018438213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P5W0"/>
    <dbReference type="STRING" id="763407.A0A167P5W0"/>
    <dbReference type="GeneID" id="28999119"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179807"/>
    <dbReference type="InParanoid" id="A0A167P5W0"/>
    <dbReference type="OrthoDB" id="2914378at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="215"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD77306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="489" mass="55681" checksum="AB5FCDDB9BDF2C46" modified="2016-07-06" version="1">MLQRRVSQHNPPTTKTSMTNLVTNGREILATTKDNRLRATTAGGLLGTKRTSLGNLRKSKSSTTADHHNQSTRQSELMTAVDMTMKRRSTGCIRQNSFNTSKNNSTITTTTATTATTANQNTKIWRPPGCYEIPNILGSDCFLKPDPPTAQEKTYSLRAYNPTKHISKRPWLPAGPRSEIPQLPPFVRPENAFERNIRKAVPKIQVSSLDPRNKYGSFKEIGTGVNGAVVRATHRYKKNLRLAIKRCRLDPDRDYKAAMIRELRIMATGHPNLIRLREVTIWRDDVWMCMDLQRCAVFAVLCQREIPEEFAVNIACETLKGLVFLHQKGFIHRDVKCENILLGWNGEVMLADFGLATRTTRRNRDRLGTSKWMAPEVIREQYYDDKIDMWSLGITVIEMMDRVPPHYMLRDESELFAAILNDTSPTFTYSYPTMYMRGLVAWLLDENPQTRPAARDVLQEIDAHVQSNLLRCASAIDLARFVNNVLSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P6K8</accession>
    <name>A0A167P6K8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_164266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295388.1">
        <property type="nucleotide sequence ID" value="XM_018434979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P6K8"/>
    <dbReference type="GeneID" id="28995885"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164266"/>
    <dbReference type="InParanoid" id="A0A167P6K8"/>
    <dbReference type="OrthoDB" id="2281380at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007891010" description="Major facilitator superfamily associated domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD77348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="60642" checksum="38B67623C0B319CA" modified="2016-07-06" version="1">MLTWLHLFTFAHAFLESSAFFVPLALVQQFDVSPKISYLVAAAFALRMTSAIWIWIIDSRPTMHGPLMACLSLTSTAALITIFFIPQSNILVWISLLFIIYHATYQPLSVILDSLIIKVLGDYRMLLFAAQRQWGLMIAPLMLLIGLVHWIYPQPLLFILVGYVTLGSLGFACIGFACTNPEAVDPSELANVNELAPFFLKNALQPTDTRTSAGPNSSIYNPLYQPYSLFGEQLSHISEEDASLLQRMASPQSLMRNPSISSHYSYGSTLSQPNLQQQQQQQQNGLFPENAYLNTNPSNNGQSIEMSFTVLPVSSLDLALIPNPCPEDPMGVLVMLRHPEDYFPYNYLTNLPLQWRIQSVLLSMLLLGIASGMLGSLLPIYLYRGLGMPLWLVCVGASVQVMCVFVVYTTIGWWIRNCSPMLLSSCVHGFFISSALCYTMLIPHSPVSWGASVFLQGIQALCLHLAWCVATSRLNAFAWIDQQRMMERGKASALYSSIGPAVGALIAGCIVGDDTTWRIGFVNLFHTTVPFVALSFVVSWGWTMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PEF8</accession>
    <name>A0A167PEF8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_164647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295797.1">
        <property type="nucleotide sequence ID" value="XM_018435054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PEF8"/>
    <dbReference type="GeneID" id="28995960"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164647"/>
    <dbReference type="InParanoid" id="A0A167PEF8"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD77757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="313" mass="34347" checksum="E9409A8A72C77931" modified="2016-07-06" version="1">MNGTLSRFSRWSSRLPPASLSSLAPIENRRPSGALAGIRLMTNLQQRPALLTTQPFCRPTLLTSRPGYSGSSTSIRAFSLWRIPIMLMTAGKTKRRIALATTLGGMTLVSAVAGPVVWLVVGGIASILAWRVWRQTSVWWKVLAPPAMTVAGVASKAGNGIFDLLKAHVGTHRAADQVQKEAISQIMKWADTPMGRRVLTEEFNADHIKDLSFLPVHSSSFSSQTIKENNKTKFDVQRVEIQFFAEDDATPGDRGGGCIVRAVATIDGNGKIRMEDIRLSAPDWTSEERIPIESLPYGDAPHRRIIEGEFKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PFT3</accession>
    <name>A0A167PFT3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier protein RIM2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_16653</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295867.1">
        <property type="nucleotide sequence ID" value="XM_018435429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PFT3"/>
    <dbReference type="FunCoup" id="A0A167PFT3">
        <property type="interactions" value="557"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167PFT3"/>
    <dbReference type="GeneID" id="28996335"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_16653"/>
    <dbReference type="InParanoid" id="A0A167PFT3"/>
    <dbReference type="OrthoDB" id="269120at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="28"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="140"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="248"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD77827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="38122" checksum="DB0243B3A4370011" modified="2016-07-06" version="1">MSELSQNRLTPLATAQTTEITRTTVKDTRSYVHFIAGGVGGMVGAICTSPLDVVKTRLQTTFYQQAKANVPTAFNKSNFVLHHFIETSRLLVRIKQVEGVRGYFKGLGPNLVGVIPARSINFYTYGNGKKFYTELNNGKETPIVHLVSAATAGLVTATATNPIWVIKTRLQLQGNGTRKYTSSFNCAANILRGEGIRGFYKGMSASYLGVAEGTIQWVIYEHLKQKWATPKKIKTTQLDLLKPANRLIDWAGHLGAAAVSKLIAACVAYPHEVIRTRLRQPAENGIHKYTGLWQCLRLIVKEEGMVALYGGMTAHLMRVVPNAAIMFFCYEAIIHNFGDSSSKPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PGH9</accession>
    <name>A0A167PGH9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_141732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295907.1">
        <property type="nucleotide sequence ID" value="XM_018430654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PGH9"/>
    <dbReference type="GeneID" id="28991560"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141732"/>
    <dbReference type="InParanoid" id="A0A167PGH9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD77867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="97" mass="11560" checksum="689AD8F6A2D8D2A3" modified="2016-07-06" version="1">MATTVQIHRPYITDHSLGIQWNRENYLRHPWLHMDLDRMNTTIHTSTYFYYESVFSNLACLEWASFLIGFLFTLSFIHTTTPLTSSEADELKDQWEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PLG3</accession>
    <name>A0A167PLG3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carbohydrate esterase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_140271</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296207.1">
        <property type="nucleotide sequence ID" value="XM_018430373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PLG3"/>
    <dbReference type="GeneID" id="28991279"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_140271"/>
    <dbReference type="InParanoid" id="A0A167PLG3"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050592">
        <property type="entry name" value="GDSL_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45642">
        <property type="entry name" value="GDSL ESTERASE/LIPASE EXL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45642:SF139">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007891223" evidence="4">
        <location>
            <begin position="20"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD78167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="408" mass="45873" checksum="4F1176CCD32AE532" modified="2016-07-06" version="1">MKPFVCLALLCLPACIASGVKHLVVFGDSYSDTGNRQRLTNGPLWNEDLAVGWDASLNNFAFSGALCDNKLYSNVSSDTPPSIRDQIEMYYREQMNHDPLETVYAFWVGVSDIQKTIQDHDPKDQNPPDFTKVVDCISQQMRNIRKVFGANRMIVLSVPPLDLLPYFQDPDLKKQWGDASKSFNKLLEKDSILLNQHHSALELDIIHVHTLLRDIVQNPASFGFVNAKDSYWDACQGQCKDKMDSYVWWDKTQLTGGAHRAIANSILLSGSLEPSSFLDENVDVEALLAKKDSIYRSPIYKPKANTGLIEKVMKDIMKEQGDSTANKPVTDNKNEGEDGDEDEDQYDDGYSINHIYLFVIIIAFVCIGFVYFAKTKRTGNLSALSGIIGNRNQGRGRFIPLRNIETEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PYF4</accession>
    <name>A0A167PYF4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_77026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296809.1">
        <property type="nucleotide sequence ID" value="XM_018443215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PYF4"/>
    <dbReference type="GeneID" id="29004121"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_77026"/>
    <dbReference type="InParanoid" id="A0A167PYF4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="68" mass="7484" checksum="5A87520B8030AB04" modified="2016-07-06" version="1">MVDDSVPESSVSAETIEKNTPSSPSLNSSRRRVHSRSPTPAFHPYTNASGKVTKAKVTRDQQTRQSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q7P6</accession>
    <name>A0A167Q7P6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_179030</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297268.1">
        <property type="nucleotide sequence ID" value="XM_018438086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q7P6"/>
    <dbReference type="STRING" id="763407.A0A167Q7P6"/>
    <dbReference type="GeneID" id="28998992"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179030"/>
    <dbReference type="InParanoid" id="A0A167Q7P6"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007891440" description="Peptidase A1 domain-containing protein" evidence="12">
        <location>
            <begin position="19"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="13">
        <location>
            <begin position="68"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="463"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="99"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="361"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD79228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="513" mass="52882" checksum="52EB85E915568358" modified="2016-07-06" version="1">MHLSTSILLCLGAVAVNAATVKHSPQVIRLPLIRNPNSKDIITQKRNIHLFKRDPAEAPLYNDDGSQYLVQLSVGTPAQNFTVTLDTGSADLWVPSTQCPQNTCPYTRFDQSASSSFKSLSQNFEITYGIGNVNGTFVTDTVTIAGVQVQNQQFGLASSTNNILTNPTTIGVSSQTSSSSSDLASNSDTVGNGILGMGFPLLTTSAGADGVAYYPLIFNMVDQKLITDPVFSIYMNTASSTGWAGELIIGGVDTSKYTGDIVYLPVAALSSTSTTSLSSLGSSANAYKGYYYWMVYGQGISLISGTTTTDVGMGSISAFIFDTGTTLTYLPQAMAKAIVSSVAGSNGYRLDSSSGTYMVDCNAVSSTVTVQLQMSTTGKTMSSPVTLNVPGANLIIPVDADTPEKASVCIFGIAPSSSSSSGGSFSMYLFGDSILRSAYLVFDIGNQRIGIAAANGVGGSVNGKSGGTSSSNTPSSSSSSSSGSSAKSGANPTLTLGLLISVLGITGSLLTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QA63</accession>
    <name>A0A167QA63_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_162431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297397.1">
        <property type="nucleotide sequence ID" value="XM_018434622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QA63"/>
    <dbReference type="GeneID" id="28995528"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162431"/>
    <dbReference type="InParanoid" id="A0A167QA63"/>
    <dbReference type="OrthoDB" id="2289822at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD79357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="253" mass="28787" checksum="617FF7BBE3ACF461" modified="2016-07-06" version="1">MERVIGVFLKLIKSKSKGGQNASFLVEQFAIHNYTSMAISICDEVNLIRPKPYGRESYMDHPNDPSGVQLWKPFHQFVNLNNDSVEGVGGPSVKEALLKYYQRTTGLNGHEFGDSVVIKNETSRGNHYVMFTCPYRNNRNVNVHSWLISTVQFYFQHVDFHGFPHFLAFVEVMKEHDAAGHDSSVPIVKQQSQSTHTLGHQMQPTYAVISVNDICYQVGLVQYPLNGNKFYVITPYYIFNNNMCITKGNLSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QE59</accession>
    <name>A0A167QE59_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_162624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297608.1">
        <property type="nucleotide sequence ID" value="XM_018434666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QE59"/>
    <dbReference type="GeneID" id="28995572"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162624"/>
    <dbReference type="InParanoid" id="A0A167QE59"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="132" mass="15354" checksum="32AF5734089554CB" modified="2016-07-06" version="1">MFVSLSNFAASKQSSIQWSCTILQDKLYIPLFFAYITVIISILCLFLRKYQNSNQPKILFRKFCLSFYINQPKAKECLGSNISSEFGLPNQNCFEDMAPLQFEHNLWNRDLAAVLKFWHILNRLKHGGVIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QFR0</accession>
    <name>A0A167QFR0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_58676</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297670.1">
        <property type="nucleotide sequence ID" value="XM_018440370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QFR0"/>
    <dbReference type="STRING" id="763407.A0A167QFR0"/>
    <dbReference type="GeneID" id="29001276"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_58676"/>
    <dbReference type="InParanoid" id="A0A167QFR0"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361:SF433">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="794"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="827"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD79630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1089" mass="123248" checksum="22C90AE1768FECDB" modified="2016-07-06" version="1">MSINTHKGSTFYQSQDVHDIASLFVDSRINSEDIHATGTDDNRISFNSQSKPNLQHLIRPSSDDVNSRTPREEYLSIHRAQMRAPESYSHDSKSSQFYGDINDHSVQRNPNLTTVSRAPVDIPPLAQSHRTSSKLLVTTTLPPPVRIFRGTQQLSAPGPMRVFGGPINKIPQTPYLHSTFAYQNPSASGSVTSRHISEGIQSFYLHPEDPGNEQVYPKPQISNFADNIIHHSTGLKSSATPLILRTDHSHPPRYAPPVLPLPPENLYRKAPRRATRTPKKQTCFKDNSRNIHLARQPAYTNPFKNPSYLDDQDRVPPIENVNSFNDNNIYLRAPMLDGESLYDGLYDNFDPVPNQASKDMLLRITENCRIEQSNTLHKIDTPAVFNPELPPLHPHDHLTQANLDYPPHGLNLPLVRNNLTIQELHKRLFETSVNNTQARYDLQRAIENHQDYRQTLERVSSQFHAYNPRGSVLSNRGIYSLDPNQLIAPTVPSAHTEEVYDANHQYWECRFANICPIENPGRKPRVVDLGDGNFQLPRSSAGSLGGGDNNAGDSFPTNSFLQEIQRAQALLPFKPRNQTISNANMTQESQNTNNRECLNVSGFGANTLPPPIPDKTQIGTLPPVHCTRTMLENFNRSIPNAHTVIDPNEHRISNAHNEVDDYLNFLIPLERPKKEISCVPEKKTRHKPSLRIDPLHKAKIAFGGKEVSPGAKRIENFIDPPKPQKYVLSKNPVIYLKYKNRYNHCYHENPWVNAGLSPSITESGTENQPRTALEELKKVMPLGKVQGKQRFDTYMMQRDLGFGANGVVKESLIPLKKPGTYLAVAIKTCSFDTAYTDENEYILREIAIMNRMRHKRIIQIYEVCLLGKVAKLAIELMACSIGRLASAMEEPMQENMAMRITRDALEGLAYLHSRKYIHRDIKCDNMMIDWGGVVKIGDFGLAIPFNKIKRGVAGTFRWMAPEVISKERYDSRADIWSLGISLIEMMDRLPPYGNSFENAKELENHIICGPTPFYMTFDPTIHMRNITKSMLTRDPHKRPRAKDLLSIINGMFDRGDYAYVTSQVLADTVKTYILPSQTYLAKKAPVQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QIQ5</accession>
    <name>A0A167QIQ5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arginyl-tRNA--protein transferase 1</fullName>
            <shortName evidence="5">Arginyltransferase 1</shortName>
            <shortName evidence="5">R-transferase 1</shortName>
            <ecNumber evidence="5">2.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginine-tRNA--protein transferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_139785</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = an N-terminal L-arginyl-L-aminoacyl-[protein] + tRNA(Arg) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="Rhea" id="RHEA-COMP:10636"/>
            <dbReference type="Rhea" id="RHEA-COMP:10638"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:83562"/>
            <dbReference type="EC" id="2.3.2.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the R-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="5"/>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297798.1">
        <property type="nucleotide sequence ID" value="XM_018430284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QIQ5"/>
    <dbReference type="FunCoup" id="A0A167QIQ5">
        <property type="interactions" value="774"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QIQ5"/>
    <dbReference type="GeneID" id="28991190"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139785"/>
    <dbReference type="InParanoid" id="A0A167QIQ5"/>
    <dbReference type="OrthoDB" id="74183at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017137">
        <property type="entry name" value="Arg-tRNA-P_Trfase_1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037207">
        <property type="entry name" value="ATE1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="7">
        <location>
            <begin position="19"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="8">
        <location>
            <begin position="147"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="102"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD79758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="387" mass="44746" checksum="3AEB058EE3CF9D0E" modified="2016-07-06" version="1">MSKKNGFSLVSLVGSNQGDCGYCHQKDTSHTFGIWAHVLTCEDYQTLIDHGWRRSGHYLYKPNLERSCCPQYTIRLNAVEYKQTKSQRKVVNKLNRFLEGDWAPKDTNSMDTTSESDQKKASKNHAKEPSQKHTLEVLLEPSSFTKEKYDLYCKYQTEIHKDEPSELKPESFKRFLVESPLREEPFEDSKPGQGFGSFHQKYILDGKLIAVAVLDILPKCVSSVYFFYDPQYAFLALGKYSALKEISLVQDFQKTVSSELKWYYMGFYIHTCPKMNYKGQFQPSDLLDPKLYTWFPIQECQKRLDKHRFVVFSDPDEHTPGDTPPGWLDVKSLKDSDLKNVHVLSDKGQLAPVTASILWKRSLKFRQNIKEYVAAVGHTMAKRLLIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QU35</accession>
    <name>A0A167QU35_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_73964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298317.1">
        <property type="nucleotide sequence ID" value="XM_018442958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QU35"/>
    <dbReference type="STRING" id="763407.A0A167QU35"/>
    <dbReference type="GeneID" id="29003864"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73964"/>
    <dbReference type="InParanoid" id="A0A167QU35"/>
    <dbReference type="OrthoDB" id="411871at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="20848" checksum="81C85C60207B5712" modified="2016-07-06" version="1">MIRISTIDDIVPLLKMIYHKNCDDIGSIIYIFGTFDPDEITLFFQYLTPCIPTYISFRNNYEISSIIDLFITNMPLINPSLHIATDLSLGSDHRLLLLSFTYDLQHSTNMPPLLRKTWNLSRLNEPDVHALYAHIFTQNSTSLLSTLQEIVQNLPLTRPNIDAITDEFNSLIYDSLNSSIGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QV27</accession>
    <name>A0A167QV27_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ISXO2-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_137880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298364.1">
        <property type="nucleotide sequence ID" value="XM_018429894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QV27"/>
    <dbReference type="STRING" id="763407.A0A167QV27"/>
    <dbReference type="GeneID" id="28990800"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_137880"/>
    <dbReference type="InParanoid" id="A0A167QV27"/>
    <dbReference type="OrthoDB" id="5598606at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053164">
        <property type="entry name" value="IS1016-like_transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163">
        <property type="entry name" value="DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163:SF3">
        <property type="entry name" value="PROTEIN CBG18017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ISXO2-like transposase" evidence="1">
        <location>
            <begin position="77"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="189" mass="21437" checksum="59AECAB4C985DF6D" modified="2016-07-06" version="1">MIATTLSQYEYVLICDKSNIRVSGSPQIAWEQHVTPRMTMGVMLSVSPETIRHLIASIHQLIQMDLTNNDRRIGGIDANGQSIIVEIDESKFGKRKYHRGHRVEGVWVLGGIEKTAERKTFLVTVFQRDAATLLQVIKKYVKPNSIIHTNCWAAYGGLASVVDMNYTHRTVTHNHWKNRNDCQSANYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QYE5</accession>
    <name>A0A167QYE5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_138029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MT-A70-like family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298509.1">
        <property type="nucleotide sequence ID" value="XM_018429918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QYE5"/>
    <dbReference type="STRING" id="763407.A0A167QYE5"/>
    <dbReference type="GeneID" id="28990824"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138029"/>
    <dbReference type="InParanoid" id="A0A167QYE5"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF8">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_82, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="433" mass="50125" checksum="6FE430773121187A" modified="2016-07-06" version="1">MSDRPRRARKQKPTVASNVHYVGYVEDAESVEAIMKKFEELERIQKEFSTMDVKEPEVDIVEEMEVESQPLTEEQLQEVFKRTSAFTVKTATMDSRAADDMDALELWQVENKDGNTDEIYEEEDYIHVDDDFWDLEFGELPRPKRARKGGPVVERVARRGVDRESILAKYKVMQVQVQDRNGNYLLVKKRVSTIDPSLPTYVKIPGKPIPRSWAHSILCKSKSQLPKPPPIASRLHTVNNILSTDLSRYGKSFSAVYMDPPLLLPGESPVPGKIHIDDLAKLNVSSVVSAGFLFIWLEKEWLQRIVSMASQWGFKYVENFCWIKKNINNQIHKSPYKYFNKSKLSLLIFRKEGDIELRHQRNPDCVFDFVKPMLPDEISEKKPEFMYNVIETLLPNAVYHPEKNPEGNGLLELWAKRGQRRTGWTTLVEQPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167RET9</accession>
    <name>A0A167RET9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_178948</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299527.1">
        <property type="nucleotide sequence ID" value="XM_018438066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167RET9"/>
    <dbReference type="FunCoup" id="A0A167RET9">
        <property type="interactions" value="465"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167RET9"/>
    <dbReference type="GeneID" id="28998972"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_178948"/>
    <dbReference type="InParanoid" id="A0A167RET9"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="8">
        <location>
            <begin position="6"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD81487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="225" mass="24576" checksum="73CE73684F99374C" modified="2016-07-06" version="1">MTASSTVIVNPITTHTATVVWIHGLGTSSASWSSFVEQLSEQFPHVKWILPNAPSIPVTFQGGQRTTAWFDIRELGLKLTINEDRDGILDSLAKINQIIKDEVDRGIPSNRIAVGGFSQGGVLSLLTALTSEYKLAAIFGCSGWIPIADTLKNLLSGANKETPIQMYHGDADYDILLEVEQNSFDFIKQLGYNVQLKVFPGMNHSFSPEEALDISSILEKNLGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PLB4</accession>
    <name>A0A162PLB4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_172001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288026.1">
        <property type="nucleotide sequence ID" value="XM_018436713.1"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162PLB4"/>
    <dbReference type="GeneID" id="28997619"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172001"/>
    <dbReference type="InParanoid" id="A0A162PLB4"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052432">
        <property type="entry name" value="PITP/CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590:SF4">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1978"/>
            <end position="2000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2012"/>
            <end position="2033"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="3">
        <location>
            <begin position="101"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1724"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD69986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="2035" mass="229432" checksum="B9A42C06F6D83B8C" modified="2016-07-06" version="1">MSAHIALFNDEFLRHANTIEKLSSRLQADLDLFDLSPYEMQDCDSYVKDRVTLFQFLRASRFNPQIAHEQLLDTVRWRIKMSIGKLSYHHFPAYFDTPCIVFDKVDRMGRPVIVLYPRNFPLSGTTTAAQSSIGSLTCLLMEVTRQYMHDLSQLHQESKHITNLISQCIILVDMSEAPFIPVNAELINYIRDILDKRFPGSIKAVHVLNFALAYQGLWQMVKFLLSDDLKHIIRFNSENELQKIMAEEDLERILGSIGSNPWVEKSEEVWKKYGYHPDIVPPKKKSRISIRDLFPEPPSSLNHIPDSLPDITNRSPRTEDITEKSGEPKENAIVNEPRKDTDLDNDQTLDGLDAENNSSIISLTSNRLLISQNINTNSDSETYTAAPGQEDQSKSLIRLTGAQNNDLGALQKLELERQPLNTYNEILEKHPYQKLASTCTYAQNTTLSKVNQYKEDSVGDSDRLDLVKVKGQSLDQVLEFTDTSINIETCITDEAIVIQLIEEDISDTETYIESDLHNTRTSEILLNDSDMLVKNNSSLLYEDSTPSNEIDDVELSMLSEVTYNDETSFVELLLDSDSVKSVNESITLPSKPYVTDNNIKTKSSSLESPDQNYNSVVCPSPTITYEAIEGFNSTPALAYQQSNTLRTNEFDEPLKHTVTEHIDSCDSDSDTHKINISPLNITTTEFPAIAKHDSTQTNSLEVDLGQTENVWNIIPDFSKAREAQKSLQENLVEILARIEDLDSPNQIECMGTYVTNEDRLTEHIINICSDEYEEYTTPILPTKKYDTNVEEYDDIFNKSLVLFDEKNHKIHENSIDSSPCVDQRDESNVAEYLDYIPSKDIMATIASVNSETLSIFADENELSRLVNGAYENVIEEKTLVCNIFPEKPSIIEIMDSFNDTPAVKALTDMIASIDDMLTGNDDTKDTPCNISSDTSAIFKDRKLSTLEPIEEEEAEVNKENDETLETEDLSNVGTDIKYHPTMSKSIIKKRPVDKTALPNEIKPFVPEVNNGGMLRIEDSTNCVSDTISSKTSDDSLSLVYKTHKEESLAAGSEICALIESDCKGLEKCSKYVSSYGELAVALSNVSNFLDLFTEDGFDKNDYTTPKKFYNRVDLIQNNEGDLINSSKTKPYDYSKSLDLETYDNEIETLLNITYDSPYIINKRKDIYGDYMCSSTYADKTAELNNSTYTSPRSEKEEYYTYSNYTDEITLMMKISYEVTRSTKEEKITRSECFDYNTYTKEILAMANISYEAPKVKNEGITCFKDLDSISYAEEAATMMNIKFNVSSSVKNETYGYSISPYSNILADEIKTMMNITYDLPLLVKEQTILPGSPGLDTFIAEVGVMMKIEYDIPYSAKKKCFPYPTFADTNMYEDEVVLLMNISYDNPESSEANRAIPSSRHVSRNCADEIDIKMKIMSYIQSQAAEGINSMDNDSITTYEDEKDFLLAITSNTILLDKATQTLADSAELNINKEEIYFETTPTHGTEITNKESTPDKTMNFNLNSYTDEVPILQSIQYDSSTFDEHIITVNSKDMEPDFDSESKDICENTNNYTNTSKALVTDILSVSYIKSCSEATPNTVTLKSTVELDNKIVGTSQNHNEKSRIEELFKTNTICEEKYKENDTTKMVTMNDPGVGDVNIGENNACEANVSEENYSERYGLSTRSVLEEKLEASIICVNARLDSGSKETTREPSAPATGIYDQRMSFMKSFLVPENGVLLSPSDTQERLESHSSASSVSKKKSTSQRPDLFNTTHVVTEVDCPSGVRLSGDMLRIKDSRKEPVSVRQDILPINLLTGPLPLPSPQPSPRMTFTRALLNTSGTTSVAIAMPLTHISNRTSDYAAITEVDMSTSSHSDSSNPNICGPLWPIVRTPMPFTTWLGIYTGITVYKSFIHTHYKTKETLKDCKCLQRVSSRNKNIHQVANSDPRFQSRSLPTRLRRASFFQTRLPTMFIWPYGSTVLDVTKRIVRATYPRYSLVYWIMLYICIRGPVEFGLSRLISQSVESPKRVATITLSIAATITAITSSSLAYFANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PLT9</accession>
    <name>A0A162PLT9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_167506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292117.1">
        <property type="nucleotide sequence ID" value="XM_018435656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PLT9"/>
    <dbReference type="GeneID" id="28996562"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167506"/>
    <dbReference type="InParanoid" id="A0A162PLT9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="126" mass="14546" checksum="F84222D790279D4F" modified="2016-07-06" version="1">MFLSIQMHNTDCHCIRCNNNNQGVSQVSRRTAQHHNKRARFEAEKRSMKVDIEIILTYQSNSVEAMDGQANSPILDVVSMFDNDVFVGNYYNGDESDTTDDNYSDDNGEEDTNEIYVEEFNNEDQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PMZ0</accession>
    <name>A0A162PMZ0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_115227</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288506.1">
        <property type="nucleotide sequence ID" value="XM_018428446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PMZ0"/>
    <dbReference type="STRING" id="763407.A0A162PMZ0"/>
    <dbReference type="GeneID" id="28989352"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_115227"/>
    <dbReference type="InParanoid" id="A0A162PMZ0"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD70466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="524" mass="57466" checksum="5E9B85359D28A45C" modified="2016-07-06" version="1">MKSFSPEEVAQHNSASDCWVIVNGMVFDVTKFLNEHPGGKKVLLKMAGKDASKQFKSFHNDAIMQRVGLPMQIGVVGTVATATTVSNLVSAPQAKFGEGLPYSDPTWYQDWNSPFYNESHIRLRKDVRAFVDKEVTPFCHEWSEAKSIPRSIIKRAAELGLLNAGSGAATNPAAKGLMPYPLPSGVSAEEFDIFHEFICVDEVARCGSGGFLWALMGGLSIGLPPVINFGSKEMKERVVPGCLSGDKIISLAITEPSGGSDVANLQTTAKDMGDHFLVNGEKKWITQGAYADYYTVACRTGGPGMAGVSLLLIERTMPGVEARAMDAQGMWGSGTSYITFEDVKVPKTNIIGKLNYGFKYIMHNFNHERIGIVMQANRFSRVCIEEAFKYSLKRKTFGQTLVEHAVIRNKFGHMIRQVEATHAWLESVLYQIKTLPVKEQPELLAGPIALLKAQSTQTFEFCAREAAQIFGGLAYTRGGQGEKVERLYREVRAYAIPGGSEEIMLDLGVRQAMKQAAAIAKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PRI3</accession>
    <name>A0A162PRI3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_187559</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290266.1">
        <property type="nucleotide sequence ID" value="XM_018439392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PRI3"/>
    <dbReference type="FunCoup" id="A0A162PRI3">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162PRI3"/>
    <dbReference type="GeneID" id="29000298"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_187559"/>
    <dbReference type="InParanoid" id="A0A162PRI3"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE DMA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17123">
        <property type="entry name" value="zf-RING_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="80"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="226"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="15"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD72226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="39226" checksum="ACB29E24BFE6D6D7" modified="2016-07-06" version="1">MLTAALSTVTASRLIPSTDSNANSHHTESSTRSTNGSNSNSDNGSKDVSPPSIRLVPHLNSPRSLVFGVIERDVANGTVLKIGRFTDKYISQTRITFKSKVVSRGHAEIWSDNNKFYIRDTKSSSGTFLNQARLSPPNQESRAFQLSDGDVVQLGVDYQGGAEEIYRCVKMRVELNRNKQQKRNAYSLNTFQTLRNLTTPPNNVSVLDAAMGFGDGDASNTHIDECCICLYAIAPLQALFVAPCSHTFHYKCVRPLLSNHPGFQCPLCRSYADLDDSVAIEASEVLEMLKKDRPVKPDVIEQEVPLTEIGDIGNFGSSLRLTTTLTDNTHPVTSLNSNSHELTSVHEESNGLEDHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PT42</accession>
    <name>A0A162PT42_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_71808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291686.1">
        <property type="nucleotide sequence ID" value="XM_018442542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PT42"/>
    <dbReference type="GeneID" id="29003448"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71808"/>
    <dbReference type="InParanoid" id="A0A162PT42"/>
    <dbReference type="OrthoDB" id="2278235at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007838838" evidence="2">
        <location>
            <begin position="25"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD73646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="168" mass="18582" checksum="F3A08F2967806866" modified="2016-07-06" version="1">MKTSCFVFLVICSISLLMCSRVSAQLGPTIIFPEHNATINATQTLKIRYEYQNMGTGNYSVDIALWLDSSATQLIQNITTNEKIVSGNSTGVRLNFTLDGTYDWVVPRGLNETIYLTVTEHADTKLLLPFTIQSSPVLLHFSAGISAFTAHSFTLTLVCLSIFLFFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PWE7</accession>
    <name>A0A162PWE7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted thaumatin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_63166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294667.1">
        <property type="nucleotide sequence ID" value="XM_018441078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PWE7"/>
    <dbReference type="STRING" id="763407.A0A162PWE7"/>
    <dbReference type="GeneID" id="29001984"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63166"/>
    <dbReference type="InParanoid" id="A0A162PWE7"/>
    <dbReference type="OrthoDB" id="430315at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31013">
        <property type="entry name" value="THAUMATIN FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31013:SF2">
        <property type="entry name" value="THAUMATIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002703">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00347">
        <property type="entry name" value="THAUMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00205">
        <property type="entry name" value="THN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51367">
        <property type="entry name" value="THAUMATIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007838351" evidence="2">
        <location>
            <begin position="20"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="30"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="140"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="145"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR002703-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD76627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="231" mass="24825" checksum="C573D27C449F0AE5" modified="2016-07-06" version="1">MRFLSIELIFLGILTVVNAGDKHITIINSCDSVVTVGVLTNGRTASSPDMTFDLTPKAERVITEQDTWGGRIWGRQQCSGSKQNSADCGTPGASNPATLAEFFFKGAFGKDFYDISFVDGYNLPMSIQPQDTEGAEGYTCGSPTCSDVPACPDENAIKGPSGQLISCQSSCSKSNTAETCCTGDHDDPNVCKPDSWSEEVKSACPDAYSFAYDDQTSTFQCTVENYHVTFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PXT1</accession>
    <name>A0A162PXT1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylcrotonoyl-CoA carboxylase</fullName>
            <ecNumber evidence="2">6.4.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">3-methylcrotonyl-CoA carboxylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_177279</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13589"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.4" evidence="2"/>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293256.1">
        <property type="nucleotide sequence ID" value="XM_018437869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PXT1"/>
    <dbReference type="STRING" id="763407.A0A162PXT1"/>
    <dbReference type="GeneID" id="28998775"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_177279"/>
    <dbReference type="InParanoid" id="A0A162PXT1"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000021">
        <property type="entry name" value="Acetyl-CoA carboxylase carboxyltransferase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000030">
        <property type="entry name" value="Acetyl-CoA carboxylase carboxyltransferase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855:SF46">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="7">
        <location>
            <begin position="32"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="8">
        <location>
            <begin position="302"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD75216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="546" mass="59936" checksum="3E983E9B6097842D" modified="2016-07-06" version="1">MSISSIKDHLVPRHPTVINKASPEYKSNIEEWTKLLDQLKERLKEATSEGKEKSIALHKKRGQLSARERIELLLDEDSPFLEICPLAGYEQEHCTLGGSVVSGIGLVSGVLCAINANVPTMAGGAMNETTVLKVGRFQQIARENRLPVIVLTQSAGANLQQQFKVFHRGGGGFRNQALASKLGIPSCCVVFGSSTAGGAYTPGLSDYVIMIKKQAQVFLGGPPLVQMATGEIADAESLGGADMHSRISGVSDQLAIDEHDGIRKAREWISNINWERQGKLPERHLLGQYEEPFYDPNEILGIVSSNIRIPYDATEVIIRIVDGSRFTVFKPNYGVNLVCGWGFIQGIPVGILANNNVIFTQEANKATQFIQLCNIKNTPVLYFQNITGFMVGKRYEEEGIVKAGSRFINAVSNSKVPAITIMMGASYGAGNYAMSGRAYEPRFLFSWPNSRCSVMGPEQLTGVMDLVMRQGAKRAGIEIDEELASQRKAMFQMSVEAESDVYYTSSRLLDDGIIDPRDTRMVIGFCLEVVYNIKVEGGNIYGISRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q0R6</accession>
    <name>A0A162Q0R6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine amidotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_15959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294176.1">
        <property type="nucleotide sequence ID" value="XM_018434015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q0R6"/>
    <dbReference type="FunCoup" id="A0A162Q0R6">
        <property type="interactions" value="287"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162Q0R6"/>
    <dbReference type="GeneID" id="28994921"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_15959"/>
    <dbReference type="InParanoid" id="A0A162Q0R6"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="65"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="261" mass="29416" checksum="487619C4996A31DD" modified="2016-07-06" version="1">MTETPSLHLALLVCDTPHPRVHEKYGDYKIMFPHVFSLAGGDEQKLTWEPFDVREMSYPSLDDLSNGKYDGIVMTGSAASAYEDEPWILKLVEFVGLMRTEPYLSKVRMVGICFGHQIMARACGGVCERNEKGWEFGLYAVKLTSEGKEVFHTDKEVINISQVHRDHVSKLPSGFKTLATTAPHTPIHSMLSDDKQCISIQGHPEFNRDTVRILIEARIESGVLTKEVGEKFLENLSNAGSEVEDIWLTKQFIQFLQGKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q8Q3</accession>
    <name>A0A162Q8Q3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_104018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299076.1">
        <property type="nucleotide sequence ID" value="XM_018427810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q8Q3"/>
    <dbReference type="STRING" id="763407.A0A162Q8Q3"/>
    <dbReference type="GeneID" id="28988716"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_104018"/>
    <dbReference type="InParanoid" id="A0A162Q8Q3"/>
    <dbReference type="OrthoDB" id="1562405at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="94" mass="10043" checksum="0EEABACBA1EEF607" modified="2016-07-06" version="1" fragment="single">VLEKFSSSSTDPSPKLGIWDKIRFCIHTQADISFVGGGDLCVVLKGLRNPYNLDGLGAGLANIWSNGVIVRIGSNNLEKEAIQITSGAFKLIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T6M0</accession>
    <name>A0A162T6M0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_175140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441002">
        <property type="protein sequence ID" value="OAD66592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284632.1">
        <property type="nucleotide sequence ID" value="XM_018437421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T6M0"/>
    <dbReference type="STRING" id="763407.A0A162T6M0"/>
    <dbReference type="GeneID" id="28998327"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175140"/>
    <dbReference type="InParanoid" id="A0A162T6M0"/>
    <dbReference type="OrthoDB" id="2289470at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="348"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="629" mass="69715" checksum="9BA88B85C27F2516" modified="2016-07-06" version="1">MATLTAVGACRSGFSLLLSSRLFKTFIRPKFEYGLAITCLLQKDVLLLEKIQDKCLRMIVGGHATSSTAVLKHICNLPSMAFRVDILKTKFCLRAHTLPSGCLLSLLHSHHLQASTLSTLHTNPLFASIPPDLNCSSRIKLSKHFESFRQEKFAHFHLTNTKILIQACRPLLEVDPVLFLSATHIERGRLVRWRMGWLPDAISNSASQSHLSCSLNFQHHPQMKTTSLTLLYQHYQSRLHIQALYIGKLFLQYYGILTCYAILMATTHMKPIMCIHPSTSLRKTIHPSRKTYLPLPKVVQSLSLVSQLSAKKISAQSDNITPSAFSIPMANLQIGNIQGLPTELTSFLTTLQAQIMNVQNRTDQLERLAAENARLTTELEHARTTIANLQKQLGSQSAPEKNFSEISLSNPAGAVGAPDKNKEPGLEASTWASKASVSLPVTAPKMSTVPSARRIAASVRMFALPSGPSGYEYVYIPRSRRLKHKEVRSSLRTLGVDSSRLLDINFPARGVIGILVHVQYADTFKAKLTTASVEILDAFDPLDPDNVADPKYASLSTHELANTAAMLHHDRCLQALQFLRPHVAIPVGHFFCEEGWISEDEIPTRTTLTNATGGSLFKRQRSSSVTMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T8G3</accession>
    <name>A0A162T8G3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TRASH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_152147</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441000">
        <property type="protein sequence ID" value="OAD66882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284922.1">
        <property type="nucleotide sequence ID" value="XM_018432849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T8G3"/>
    <dbReference type="FunCoup" id="A0A162T8G3">
        <property type="interactions" value="683"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162T8G3"/>
    <dbReference type="GeneID" id="28993755"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152147"/>
    <dbReference type="InParanoid" id="A0A162T8G3"/>
    <dbReference type="OrthoDB" id="10262490at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="3">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD66882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="159" mass="19139" checksum="80ABA48D0A90D049" modified="2016-07-06" version="1">MHIERCYFCSGPCYPGHGTMFVRNDSKTFRFCRSKCHKNFKMKRNPRKVRWTKAFRKASGKEMVIDSTFEFEKRRNVPVRYDRNLMATTIKAMKRVQEIRVKRERAFYKTRMADNKEKDRAEDVRVVQQNIELAPLDAKKRIQAMKLSEKNTEKMEMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T975</accession>
    <name>A0A162T975_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_176376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441030">
        <property type="protein sequence ID" value="OAD65183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283223.1">
        <property type="nucleotide sequence ID" value="XM_018437752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T975"/>
    <dbReference type="GeneID" id="28998658"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176376"/>
    <dbReference type="InParanoid" id="A0A162T975"/>
    <dbReference type="OrthoDB" id="2286816at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="165" mass="19460" checksum="7802563DCFE59006" modified="2016-07-06" version="1">MSHLPGVLFFWKDPERPIDMILLQSDQSKSFDVVEQSEIERRMAYLVSHPDDRDVRHIPATMNEARMGFIPQGTNKTPSATARINALINYLWKKQKGTDVNISALEQKLIRLQFHMYTRQCWCIMKDDGVVKVNWGKLNSQKKLYYSLRLEELIFNNYNFPLYEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TEJ0</accession>
    <name>A0A162TEJ0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Basic-leucine zipper transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_152318</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441002">
        <property type="protein sequence ID" value="OAD66513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284553.1">
        <property type="nucleotide sequence ID" value="XM_018432888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TEJ0"/>
    <dbReference type="STRING" id="763407.A0A162TEJ0"/>
    <dbReference type="GeneID" id="28993794"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152318"/>
    <dbReference type="InParanoid" id="A0A162TEJ0"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="141"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD66513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="245" mass="27689" checksum="DBDAF41BC610EA99" modified="2016-07-06" version="1">MINYNHPTTFQAPTIGEQSDILDTSFWNINGHHPLGPNGNTFDYLKQDFHQGHHHIQTQMHPTSPTDQMFNLVGSIPSIPSSLSASPTTSVHANVSGFASLDQSQNDILEGYSDVSGSEGSSEPDNRASKKRKNSDDSMPTEVRKKFLERNRQAASKCRQKKKAWMVELENAYVEREKENRELLAQISKLRNHTLYLRDQLLAHSNCECSVVKNYLQRTAQQILDRATEESVMGQAHTQGMSWHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TI12</accession>
    <name>A0A162TI12_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_177394</name>
        <name evidence="6" type="ORF">PHYBLDRAFT_30308</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285363.1">
        <property type="nucleotide sequence ID" value="XM_018439962.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293061.1">
        <property type="nucleotide sequence ID" value="XM_018437880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TI12"/>
    <dbReference type="FunCoup" id="A0A162TI12">
        <property type="interactions" value="487"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TI12"/>
    <dbReference type="GeneID" id="28998786"/>
    <dbReference type="GeneID" id="29000868"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_177394"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_30308"/>
    <dbReference type="OrthoDB" id="2365484at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.770:FF:000001">
        <property type="entry name" value="60S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018262">
        <property type="entry name" value="Ribosomal_eL27_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="Ribosomal_eL27_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01107">
        <property type="entry name" value="RIBOSOMAL_L27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD67323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD75021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="136" mass="15606" checksum="C3797350824B3123" modified="2016-07-06" version="1">MVKFIKAGKVVVILQGRFAGKKAVVVRNHDEGTKDRPYGYAVVAGVERSPLKVTKGMGKKKVAKRSKVKPFVKIVNYNHMLPTRYALELEQIKGTVSADSFKEPSQREESKKVIKKLFEERYQTGKNKWFFSKLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TLJ8</accession>
    <name>A0A162TLJ8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_156415</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate</text>
            <dbReference type="Rhea" id="RHEA:22936"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="3.5.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="2"/>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286123.1">
        <property type="nucleotide sequence ID" value="XM_018433487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TLJ8"/>
    <dbReference type="STRING" id="763407.A0A162TLJ8"/>
    <dbReference type="GeneID" id="28994393"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_156415"/>
    <dbReference type="InParanoid" id="A0A162TLJ8"/>
    <dbReference type="OrthoDB" id="10264777at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000065">
        <property type="entry name" value="N-acetylglucosamine-6-phosphate deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="11">
        <location>
            <begin position="61"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="11">
        <location>
            <begin position="358"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="242"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="356"/>
            <end position="358"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD68083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="434" mass="46434" checksum="7F41B43BC5501601" modified="2016-07-06" version="1">MSIAYSTSKIYKIINGRLLINHEIVENSYLWYQDGKIIHPQSLFFDHHRDADEIIDAKGLLVVPGFIDTQINGAYGIDFADYEHSVETIQENIDIVAKGLLRYGCTAFCPTVVSSSPEVYEKVLPLLNHRKGSATGGAEILGAHVEGPFISVEKKGAHKQSVFRDAKEGIAAFDSAYGSELLKGSKAVAIMTVAPEIEGVSDAIPDLVQRGITVAIGHSACRIAEAEQAVTNGATSITHLFNAMQAFHHRDPGLIGVLGAADLPLPTTSKGHPKPSLTSPCRHSPDPRPFFGLICDGVHVHPNSIRIAYYSHPSGAVLVTDALSAMGLPEGEYTLGGSELQVDKNGAAYIKGTSTLAGSTVTIDECVRNFQKFTNCTAVEAIEAATLHPAQLLGIEHQKGTLNVGGDADFVFLDDSTGELRVEKVFVAGDEVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TMN2</accession>
    <name>A0A162TMN2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongin-C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_160154</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286413.1">
        <property type="nucleotide sequence ID" value="XM_018434125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TMN2"/>
    <dbReference type="FunCoup" id="A0A162TMN2">
        <property type="interactions" value="367"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TMN2"/>
    <dbReference type="GeneID" id="28995031"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160154"/>
    <dbReference type="InParanoid" id="A0A162TMN2"/>
    <dbReference type="OrthoDB" id="249087at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18321">
        <property type="entry name" value="BTB_POZ_EloC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000035">
        <property type="entry name" value="Elongin C transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="ELONGIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="10"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD68373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="104" mass="11980" checksum="EA2EEBAFF097CC4E" modified="2016-07-06" version="1">MSEVESVSEYVKLISSDGFVFVIHREAAMRSGTIKNMLVGPVQFKESVESEIPFRDIKAVILEIVCRYLYYKWQYEGSTTEIPEFKVDPEVVLETLMTADFLEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TP82</accession>
    <name>A0A162TP82_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_171997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288022.1">
        <property type="nucleotide sequence ID" value="XM_018436711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TP82"/>
    <dbReference type="GeneID" id="28997617"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171997"/>
    <dbReference type="InParanoid" id="A0A162TP82"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="164" mass="18668" checksum="2B01FD5FAC787828" modified="2016-07-06" version="1">MANLKRCGLYSMSMLWYTVGCVSTRCRSVKCVLCLAFFKEEFRSPGEKDLPKDIMTKFFEISSKCRSFNSVLIKAIVSIFCTGSSRFTILTTLCDLKNTEKLIPLSNMAFIIYTYEEVEEEGEGEGEGEGEGEGEGEGEGMYYIRVRTRTRIHFPIYKTSEDCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TPJ0</accession>
    <name>A0A162TPJ0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_150365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286813.1">
        <property type="nucleotide sequence ID" value="XM_018432461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TPJ0"/>
    <dbReference type="GeneID" id="28993367"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150365"/>
    <dbReference type="InParanoid" id="A0A162TPJ0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="102" mass="11618" checksum="15573EA51EC1A695" modified="2016-07-06" version="1">MIEQDLGISPTAEVKGTINTCIKHICDQLAALSSVQILRPNPSWTSIPQEDWTRMCVSHSHVLKNYGIDFTRCHKNWASITKVSQLWRSCRKQHLSANTINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TQ29</accession>
    <name>A0A162TQ29_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_171558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288212.1">
        <property type="nucleotide sequence ID" value="XM_018436626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TQ29"/>
    <dbReference type="GeneID" id="28997532"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171558"/>
    <dbReference type="InParanoid" id="A0A162TQ29"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="127" mass="14882" checksum="551AF55365921A33" modified="2016-07-06" version="1">MFVDVHKSYLMNFPEPLVTEKPAIGTICGKLSSINIRKNVQQKLLNITFIILIEISEFLLVVLIREKTKCLLYIMEILKTVVSSGFFSSRNKYGFIKEINHRNCKYLYICSVFWLYLETSSKYIEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TWR5</accession>
    <name>A0A162TWR5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_135131</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat rae1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288473.1">
        <property type="nucleotide sequence ID" value="XM_018429699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TWR5"/>
    <dbReference type="FunCoup" id="A0A162TWR5">
        <property type="interactions" value="1152"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TWR5"/>
    <dbReference type="GeneID" id="28990605"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_135131"/>
    <dbReference type="InParanoid" id="A0A162TWR5"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000190">
        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="53"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="94"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="235"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD70433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="330" mass="36427" checksum="4AEB096DB7C15C06" modified="2016-07-06" version="1">METPDFEIASPPTDGISALAFSSQADYLAASSWDNQVRIYEIQPSGNTAPVASYAHEAPSLCVTWSKDGTKILSGGADKAARMYDVTTGQSTQVAEHADAVKCVKFLDQGQQILATGSWDRTIKYWDLRSPQPIGSVQLPERCYSMDSVGNLLVAATAERHILLFDLSNPTTIFKQTISPLKWQTRTVACFIDGKGYAVGSIEGRVGIQYIDEKEQSKSFSFKCHRDDQKNVYSVNAISFHPTYGTFSTAGADGTINFWDKDSKQKLKLLPNVNGTVACTAFNRTGNIFAYAVSYDWTKGYKFAGQNPTNKIMLHAVRDEEVKPRPSTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U4M3</accession>
    <name>A0A162U4M3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_66001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291432.1">
        <property type="nucleotide sequence ID" value="XM_018441569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U4M3"/>
    <dbReference type="STRING" id="763407.A0A162U4M3"/>
    <dbReference type="GeneID" id="29002475"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_66001"/>
    <dbReference type="InParanoid" id="A0A162U4M3"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36050">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36050:SF1">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="499" mass="58134" checksum="C7CF88845AAF3D7C" modified="2016-07-06" version="1">MGLRTKLLWPLIACLTYLFFFTVRLKPVTDNSSELDPATIAAIEEEELRLLQQNEQDSSWQWQYIPHHQPDLEQLTANEPLETLVVPEVTYRPDEKFITFLTHSGFQNQLIQGKYRFENGILLAWYLNRTLLLPNAFLGEAFGWSNFDKLHLEHMLRDSSTTETCSEFAEGLVEWGIECPPRGRYAVLPFDEIFDLSWAKKHVRILPRQRSDFGWLEKEFDIQRDNVPNHVNGSYRDGDILFFKGETRYDWRIFDTPRKNHRLGKYADSLDIYQLRQRPERLLHFSSLFGTGKLPIRRPEHYEFLRNLQRSIIYRHPAVLTMAEKIVDRLGGHGDGWFIKALPENVNNIISQIQRAVESHQPGSLRAILRPTEQRLTLDQCRHLAATQNVTLVYMATDARSPQLNPAFDPVWNLFPCTFTLDDIFSPLSSDWDTLERVVDRNSGASLRKFLVPLVDATVASRGWFFIGSKGSTFSGYIYRLHDVFWSNEKRQQLGLEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U7H4</accession>
    <name>A0A162U7H4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_113141</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291033.1">
        <property type="nucleotide sequence ID" value="XM_018428330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U7H4"/>
    <dbReference type="STRING" id="763407.A0A162U7H4"/>
    <dbReference type="GeneID" id="28989236"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_113141"/>
    <dbReference type="InParanoid" id="A0A162U7H4"/>
    <dbReference type="OrthoDB" id="2382881at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF9">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="93"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="201"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD72993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="31429" checksum="2EED54A625E8373F" modified="2016-07-06" version="1" fragment="single">NRTIVAASSAAITSVTAGFPFDSLKTRMQTHHYNSVLSCLKITFAEEGARGFFRGMIPPLVTVSIIKSVSFSIYENTKARLKEQGIKGDTLQSTFGLSMLSGGASGAFIALLSCPLELVKIQRQLEYVAMKEQAALGVVTGGPVRSSSLYAAQQIVSRKGILGLWTGVRLHSGRDTLGTSIYFGSYESAKFIISGGNSAASNPLTHFMAGGCCGVLSWLVVFPVDLVKSVIQKDVLKSKVQGFRECASDIVRREGIRGLYKGLSITLIRAFPIHSLNFLVYEQVLRKIPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U945</accession>
    <name>A0A162U945_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_167871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292502.1">
        <property type="nucleotide sequence ID" value="XM_018435736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U945"/>
    <dbReference type="GeneID" id="28996642"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167871"/>
    <dbReference type="InParanoid" id="A0A162U945"/>
    <dbReference type="OrthoDB" id="2284196at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF1">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD74462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="428" mass="48142" checksum="A555BCBE370DF343" modified="2016-07-06" version="1">MVHFLDKGKPENNESSNSLHRSPASMSSSSYSSSSRTPESISIAEQHNLSNTLPRMHYILLWNIILEALVVSALEAALIYYHVSFSSHCVLSITNMGLSLANVTHHGLAIITQVYQVLLYIDLLKQHNMPQLCMTMIFQTLILVFAIIKVYHSSLKDFMICDDSLEGNNTFSTTNYPLVFTRNDTEFYKTKFQSLEYAVFGVTLACSIVFLLCLIRLYRASTWTSHYLHSFDDNTKKAILAATALVSLLKFDAFFCFFYIVQLVPATITGYPVPYWEVPAVVLASALILLLGWYAVLKESSQLTLAFATATILSFGYFVYRIISLSLVSVLNQEILKIIRSYLQLSISITLVFTLLTIVVSLTCFLNQIRGINLPQPMCHSCTHPQKKPPPMVPEHTEPPYSMGTALRSEPKQSTDTCFFSDCHSVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UC08</accession>
    <name>A0A162UC08_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_168386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292013.1">
        <property type="nucleotide sequence ID" value="XM_018435860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UC08"/>
    <dbReference type="GeneID" id="28996766"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168386"/>
    <dbReference type="InParanoid" id="A0A162UC08"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="122"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD73973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="458" mass="50165" checksum="56A8AF9B884F4BD6" modified="2016-07-06" version="1">MPNAELTENNTLIPNHLPTHQNNLSNDIPTASIRLETISRAQEQSVPYTIFKFAATDLKTPTTPPEANSQPKPRILAKRNKAQTLALQKQKRAVSTRSIINKNHANLIEGVFIYNKDKATTLAASQQERATLEAIIANLTDKFEELAANYQSKLEKLDGLMALQAAGAARAAFESTGKGSLMASKHAPKALTVDSNSNICIRCANCSTTTTTNSNKNNNSNNNSNNNNTNKKSNTQNKTGSNAVAGQMSYATQAKKGIDAKQAKQKVQVRRVQGQRLLQKPTGPSEYKFVYLPAKRYVKYQEMRKILSSFKISTSHILDIQFPGRGTVTLLINGEFREELIALLGKAKVVPLGNFDPTAADVIADTKLKEKTIKVRAKKAQDLFDARLVKASLRMATYLGHSVICHFSSKKAVVKISQTAVSDYLEGRKTTSTTAFVAPTNDMDGIESTKTPITTTHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UDW8</accession>
    <name>A0A162UDW8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_167816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292443.1">
        <property type="nucleotide sequence ID" value="XM_018435730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UDW8"/>
    <dbReference type="STRING" id="763407.A0A162UDW8"/>
    <dbReference type="GeneID" id="28996636"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167816"/>
    <dbReference type="InParanoid" id="A0A162UDW8"/>
    <dbReference type="OrthoDB" id="5865767at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="414"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD74403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="588" mass="66047" checksum="B923F5652E90947C" modified="2016-07-06" version="1">MILKLCVINNLHDEITKVKQNYEDFQYSFLSVAKTDLFYIEFKNIPSVLLSNLSLHHCIPAFETNKINIFRFLNMTDPVEFSSIGINPHDSHKLSLFVKAFQDSRRDAGYTPKSTRRSFSSSTSSQYSASESGSRSSTQSTFLPLENEWLKDNLHETSPFLDAYESQEGKQDLLRAVTELEYMIKDPQTKSPTDTTTNTGPTLTLTPTMLSLKDICSSNKSSSTQLSAISAFSATTMVALPEEETDEANETRECIDDHKQNTRVVQNMQSPSLNTNHSFHLLPLRLPLPLTPPPLYDTNSAEPTFNPALLSPSSCLRLEGPAGIAVPRPRKQLSPSVSPRPVSMPAYLHPNSRIPSTANNASGGGGNRTQYNTLSLPPPPDYLESTLGGWGRNKGLILPREEEGREELPPYICTVYKIGYVSIKFEKDNPDTKSRWRLWRNLYVELWGTALRIYRSEPSDSASGLRLSRLPSLVPWSRYTSVPLLTLSLAGAEATRALDYTKKPNVLRLTVPNGPQLLFKQDTTIEMISWIEHLQASINISLDLEHRPMPKFVTLYVRGSNEPTLAARTIELERAREIRRNAQEEVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UH11</accession>
    <name>A0A162UH11_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_59708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294212.1">
        <property type="nucleotide sequence ID" value="XM_018440545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UH11"/>
    <dbReference type="GeneID" id="29001451"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_59708"/>
    <dbReference type="InParanoid" id="A0A162UH11"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="196" mass="22679" checksum="B4ABDFA96F0EDDD1" modified="2016-07-06" version="1">MSCINKIGITQILVLSDYDKELFLFTLSASHLIKPHIEYRNFQNLTCTQESGDTLLSIKVKGRNRGGFLSRKASPRITSKITLKIALYPYRVYSYYVLVAIKFYNVNHLKEVSNRPFSSLIKKYTGRLKSGICLCDTVLVIIMVEYHSDAIEATQLNSTDYFTIQFKSTFLRAIHIQGFQDPWLIAQKKLIRRIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UZ69</accession>
    <name>A0A162UZ69_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted cell wall surface anchor family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_62303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296972.1">
        <property type="nucleotide sequence ID" value="XM_018440952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UZ69"/>
    <dbReference type="GeneID" id="29001858"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_62303"/>
    <dbReference type="InParanoid" id="A0A162UZ69"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007840287" evidence="1">
        <location>
            <begin position="20"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="525" mass="58283" checksum="33057352844C2DC4" modified="2016-07-06" version="1">MKLFGVFLSAVLVVSLANAFPSEPSTCDLLAISTYQENTKANPNIQALIDDAVDKGRSVVKMGSGQWILPSDYPIVLPPGVSLSGDPKNPTVLTVIDKNTTGTILVPALNRGWTIKGLILDNVNILIDPHENDDETSILGNIFINGGRGSIVSNYGEQLYVDGNVFLRDRSHAGTHLIPNYNTTNTGVLFQTQKNSVISNNIFGMDLRQVDNLSPWVSSQLQATLNKLKFYTQCLGRNLDDQQGYLASAVQLYSTNDITIKENVMNATFPDIEMTEQDHGVSIVGSNQTYIYQNFIAGWQLGDFGGAMRFTSAVDGYVVSNYLANTAVMLYAAVHADFMQVSNMVVADNFLYRFMDPQRDLNSPVYGWLYEGITFFDFYTARNNYTIRPPIWNSSVPISPWGWNIEITHNKFAATADLDPNVISLGNLDLKEASVDTTNCYVTRPLDPKASVPGQVPVLWRQTYLLDRHGLNGARIPMDLYVRPEEDLDNAVPAHLRNLSIPPFWRAFTLKNNTQPMMDPSTPCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V3D4</accession>
    <name>A0A162V3D4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_106408</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297713.1">
        <property type="nucleotide sequence ID" value="XM_018427947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V3D4"/>
    <dbReference type="FunCoup" id="A0A162V3D4">
        <property type="interactions" value="259"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162V3D4"/>
    <dbReference type="GeneID" id="28988853"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_106408"/>
    <dbReference type="InParanoid" id="A0A162V3D4"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02660">
        <property type="entry name" value="Peptidase_C19D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF937">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="6">
        <location>
            <begin position="113"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD79673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="441" mass="50789" checksum="D6E2DFB2C89E70BC" modified="2016-07-06" version="1" fragment="single">PQCTTCQDPMSRLHVCLHCVYMGCWRKGHMLDHLKEKKHMLAMDFTHRTLYCYGCADYVYDLELEDVIVRQEMIRYESSKKRSRVMYTSWEPTEQEASELVQKSLLISCQGIRGLCNMGNTCFMNVILQSLVHNPLLKAYFLSDRHNPKYCDNKYCMCCEMNNLFKQASNYLFCFIYSSEKGPYGPCSFLMSMWMSLKELAGYAQQDAHEFFISALNNIHAGCEGNTMVSCNCIIHKTFAGVLQSNVTCLGCGNVTTTYDPMLDISLGLRPVERKKKQGNTLMDCLDRYTQPEKLGNNEYSCSKCGNTFQEATKQLSVKRMPPVLSFQLKRFEHGGAATKIETKVRFPVELDMTPYTTDGKKDQSSINTANMYTLFAVVNHQGKLDTGHYTMFAKHRGEWFKFDDHSVTLAYQKDVLDSKAYMCFYIKESLEYEDSHRNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V888</accession>
    <name>A0A162V888_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_88191</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298772.1">
        <property type="nucleotide sequence ID" value="XM_018443689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V888"/>
    <dbReference type="STRING" id="763407.A0A162V888"/>
    <dbReference type="GeneID" id="29004594"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_88191"/>
    <dbReference type="InParanoid" id="A0A162V888"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06606">
        <property type="entry name" value="STKc_MAPKKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000182">
        <property type="entry name" value="MAP kinase kinase kinase mkh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF48">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BCK1_SLK1_SSP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="52"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD80732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="330" mass="37987" checksum="0B5F7E26E0F084B0" modified="2016-07-06" version="1" fragment="single">NNTLLRRKSTKLWDTPLLEVKPQRKRRLNQYNHSQYHPHHNQPVQVPQAVQWIRGQLIGKGSFGRVYLAFNVNTGDVIAVKQVQPHQQNHHQNHQNHQHDMVKALYQEIAMLKDLDHDNIVQYLGYGQDEAEGVVHIFLEYVSGGSIASRLQLRGGFDERLVRYFTYQILLGLSYLHSKSILHRDIKAANILVEADGVCKISDFGLSKKNDYSQVYDANSRMSLRGSIYWMAPEVVKNEPYSAKVDIWSLGCTVIEMLTGQRPWIAFNQIATLYNLGCLKSPKIPKQISKEAKDFLELCLQIDPDKRPTAQELLSHSFCYQDPDFNFQVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WVA6</accession>
    <name>A0A162WVA6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_171107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD71045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289085.1">
        <property type="nucleotide sequence ID" value="XM_018436512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WVA6"/>
    <dbReference type="GeneID" id="28997418"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171107"/>
    <dbReference type="InParanoid" id="A0A162WVA6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="200" mass="22594" checksum="D439656F2AA4F3B3" modified="2016-07-06" version="1">MKAIPLDALLLREMTNSLAILRRDMTTVMKDVADIKAKTSNTSVSAVLQSQPMALVHAVAPVSMEMNVAGSPTMASDAKSVNKTKAYNTAVNFNQSPNTELTENLVAYLERNFVGAGLRKSDVRDFVYTNFTSRKRAANKSQAKKKSDNAHNRHCKRRVDSVEFYFLNFGKIWKNISNTIVFQYIFFLRCEFAIFSDYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162X2C4</accession>
    <name>A0A162X2C4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHYBLDRAFT_75255</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11"/>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290185.1">
        <property type="nucleotide sequence ID" value="XM_018443050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162X2C4"/>
    <dbReference type="FunCoup" id="A0A162X2C4">
        <property type="interactions" value="757"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162X2C4"/>
    <dbReference type="GeneID" id="29003956"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_75255"/>
    <dbReference type="InParanoid" id="A0A162X2C4"/>
    <dbReference type="OrthoDB" id="361536at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02658">
        <property type="entry name" value="Peptidase_C19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14385">
        <property type="entry name" value="UBA1_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14297">
        <property type="entry name" value="UBA2_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000086">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000103">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000396">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF664">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016308">
        <property type="entry name" value="UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10 11 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="18">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="18">
        <location>
            <begin position="159"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="17">
        <location>
            <begin position="310"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="16">
        <location>
            <begin position="587"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="16">
        <location>
            <begin position="647"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="686"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="694"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="731"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAD72145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="777" mass="86936" checksum="A74F287C044DE902" modified="2016-07-06" version="1">MACPHIKNTSFKVPSAYTQVHKEECTQCFESQDGLGGIDVCLTCFNGGCAETEQCHAKTHYNTSHHPLAVNIRRRIVSEKPKRTEDESPPPQKISKLAIVPDSETIKYEFFTKVRCRACPGVEVSKDTTPELNAIVEAILATLSSAKQSEVKAWEEEIYPCEHTLCLTQDSPKKLETQDLAHCTECDLKENLWLCLTCGTLHCGRKHYDGSGGNNHGIEHFEKTWHVVSCKLGTITPEGTADIYCYKCNDAKLDNELAVHLANWGINISQQLKTEKNMTELQLEQNMKFDFSMTTEDGKQLEPKFGPGYTGLKNLGNSCYMASIIQAVFDINTFQDRYFIQLQDHASVCQNDPANCWDCQLHKLADGLLSGNYSLPIPSTTDNDTLSQEGIAPGMFKTLFGKGHEEFASMRQQDAYEFFQLFCKTVSQKEHTNKDQDPTQTFEFSLEQRLQCGKCRKIRYQVDPSSSLSINVPAKRIGEEDSKTLYEPVGFYECLDNFVQEDTVEGYNCPHCKEKTTAFKSVKFNTFPDVLVIHARRFAFVDWVPRKLDVKITFPKEPINLDKYLGTGQQPGEDVLPEDEVLAEAPSFDQSAVEQLMGMGFPEIRCQKALINTGNNGAEVAMNWLFEHMDDPDIDAPLATAPPSSGPTDDQITTLCDMGFTPAQAKKALRETNNSTERALDWLFNHPGDLGEAGSSDPSSGPSIPGDATPPFDYRVKSFVSHKGTSVHCGHYVAHVRKEGEWVLFNDNKVAIAPNPPIGEAYVYFLQRFHSGKSYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162X7D5</accession>
    <name>A0A162X7D5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_146262</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290985.1">
        <property type="nucleotide sequence ID" value="XM_018431612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162X7D5"/>
    <dbReference type="FunCoup" id="A0A162X7D5">
        <property type="interactions" value="670"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162X7D5"/>
    <dbReference type="GeneID" id="28992518"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146262"/>
    <dbReference type="InParanoid" id="A0A162X7D5"/>
    <dbReference type="OrthoDB" id="27537at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="101"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD72945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="315" mass="34621" checksum="C0675AD114A44AE9" modified="2016-07-06" version="1">MTPEIVSCYKTAKTFRLGDRPVSALSFSDNGELCVTSSEDDSIHVIDCLEGKQKSTLFSKKYGVNLARFTHHTNAIVHASTKEDDTLRYLSLYDNQYLRYFQGHTKRVVSLGMSPLNDNFLSASLDGSIRLWDLRAAGCEGAMDVNGYPTVAFDPSGRVFAAGHSSDKISMYDLRAWRAGPFLTNQIDQGVAGWKGISFSNDGKNLLLSTTGNSHYILDAYDCTIKHQLVGHTGSTLGMCTEAAFWSPDGRFVYAGTSQGMLNVWDTQQEAFELSPFKTFNTPHQQEGTRVAGHNPTTAMMVTGGDVVALWLPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162X950</accession>
    <name>A0A162X950_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_65922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291355.1">
        <property type="nucleotide sequence ID" value="XM_018441556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162X950"/>
    <dbReference type="GeneID" id="29002462"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65922"/>
    <dbReference type="InParanoid" id="A0A162X950"/>
    <dbReference type="OrthoDB" id="2288766at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="34360" checksum="759208E9FBD9A546" modified="2016-07-06" version="1">MSIPTNSTNVPPIIPIVSQQEGQIAVNASTFEKNIEELTGVDTSIPSKNSFVSRMTGSQYAPKVTGNEAFVLNKESKRISRQKAEKLLSKYKRESYCLLSALYDANILKDRHCTEQMERIHSILKVTENISPINTTGNNISVCDIPLFQIIGYSVPDQNSKVYSNVEHYLSAFEKLMTIGCEHIDSAWSRWLPIAMTHEYDTWYLENLSNKNLTWAKARAIIKKYYNTEEYQCIMATEALAMYMGPNETIQDYGQRFQRACREGNIGQDGLISIRFLSSLTPALSHATFSAWFTHNNKEPDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XFH6</accession>
    <name>A0A162XFH6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_167962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292595.1">
        <property type="nucleotide sequence ID" value="XM_018435764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XFH6"/>
    <dbReference type="GeneID" id="28996670"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167962"/>
    <dbReference type="InParanoid" id="A0A162XFH6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="227" mass="26103" checksum="E2C8F77204686602" modified="2016-07-06" version="1">MFGLAQTRQIGSLAKQNTEQPKSQLLSYDDSSAGWPLTEGGECVSAKSDIEFWEPLRCRLIDENFKGISYLLILIQAFYKSKGVECSRIELIIITSCKIFVNSCVIDSSFAQTLLKEAHHICLQVQVDLFHNVHQTYIPIIKDFFELQKILQRHHTAGQLKFCLTLTIIITFCIKNIKARMVKWYNLRLPREGPGFDSRSAHLLQLSFLIWVVLSDIILMNPRNRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XIA8</accession>
    <name>A0A162XIA8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Glutamate synthase [NADH]</fullName>
            <ecNumber evidence="8">1.4.1.13</ecNumber>
            <ecNumber evidence="20">1.4.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">PHYBLDRAFT_78911</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Forms L-glutamate from L-glutamine and 2-oxoglutarate. Represents an alternative pathway to L-glutamate dehydrogenase for the biosynthesis of L-glutamate. Participates with glutamine synthetase in ammonia assimilation processes. The enzyme is specific for NADH, L-glutamine and 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>2 L-glutamate + NAD(+) = L-glutamine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="1.4.1.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>2 L-glutamate + NADP(+) = L-glutamine + 2-oxoglutarate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="1.4.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="26">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="26">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Energy metabolism; nitrogen metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glutamate synthase family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_018443399.1"/>
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        <property type="reaction ID" value="UER00690"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0051538">
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        <property type="term" value="F:flavin adenine dinucleotide binding"/>
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        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd00713">
        <property type="entry name" value="GltS"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.20.20.70:FF:000031">
        <property type="entry name" value="Glutamate synthase 1 [NADH]"/>
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        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
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    <dbReference type="FunFam" id="3.40.50.720:FF:000113">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
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        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.60:FF:000001">
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    <dbReference type="FunFam" id="3.60.20.10:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="entry name" value="Glutamate synthase, alpha subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
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    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012220">
        <property type="entry name" value="Glu_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051394">
        <property type="entry name" value="Glutamate_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008730">
        <property type="entry name" value="PRK11750.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR43100:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000187">
        <property type="entry name" value="GOGAT"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
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    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="Alpha subunit of glutamate synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="19 26" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0274">FAD</keyword>
    <keyword evidence="10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0288">FMN</keyword>
    <keyword evidence="18" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="14" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="16" id="KW-0408">Iron</keyword>
    <keyword evidence="17 26" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="27">
        <location>
            <begin position="30"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="28">
        <location>
            <begin position="1600"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="25">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="1148"/>
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        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="1154"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="1159"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00057049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00068518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="OAD75065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="2075" mass="227761" checksum="FAB93371E9DA8FC8" modified="2016-07-06" version="1">MSTITNNNSWAGAIPAAQGLYNPELEKDACGVGFMVHVKGVRSHKILSDASSILCNMTHRGASGADIRDGDGAGVMTGIPHQFFVNETQRELGISLPQEGQYAVGNLFMKGDEDSVQESKMVFETLASSLNLNVLGWRSVPRDSTIIGPAAKSKEPAIVQPFVVLADQSDFDEQRFERQLYVLRKHATHTLTMKKWFYVCSLSNKNIVYKGQLTPKQVYQYFHDLNNVQYTTHFALVHSRFSTNTFPSWDRAQPMRWCAHNGEINTLRGNKNWMRSREGVMASDKFGSELELLYPIIEEGGSDSAAFDNVLELLVINGVVSLPEAVMMMIPEAWQNNDAMSPDMKGFYRWAASLMEPWDGPALFTFSDGRYCGASLDRNGLRPCRYYLTTDDIMICASEVGTVYVDPETIVQKGRLQPGRMLLVDTVEGVIVDDKELKQKTAAKFSFNEWVKSQQITLTSIVDKAREESAFEVQLDDYSVQTDPRLKAFGYTLEQLNLLMIPMASTGKEALGSMGNDTALACLSEQPRQIYEYFRELFAQVTNPPIDPIREEIVMSLECYVGPEGNILEIDEAQCNRLALPSPVLSMEELSAIKSMENFYPSWKVATIDITFAKETGIQGYVDAIERVCTEVTQAIEDNYKVVILSDRAVSSDRVAISSLIAAGGVHHHLVRHKQRSKIALMVETAEAREVHHFCVLLGYGVDAICPYLSMEAMMKLCREGAVHEGLTAQKLIYNFKKGIDNGIMKVMSKMGISTLASYKGAQIFEALGVDDTVISRCFTGTASRIKGVTFDIFALDALTLHESGYPSRNIVQPVALPESGEYHWRDGGEAHIADPSGIANLQDAVREKNQSSYDAYTRNAYEAIKKCTLRGMLEFDYEKAKPIPIEQVESWDSIVKRFVTGAMSYGSISMEAHSSLAIAMNKLGGKSNTGEGGEKPARSIPLENGDSMRSAIKQVASGRFGVTSFYLSDAEELQIKMAQGAKPGEGGELAGGKVSEEIASTRKTTPGIGLISPPPHHDIYSIEDLKQLIYDLKCANPRSRVSVKLVSEVGVGIVASGVAKAKADHILISGHDGGTGASRWTGIKYAGLPWELGLAETHQTLVLNDLRGRVIVQTDGQIKTGRDIAVACLLGAEEWGFATTPLIALGCTMMRKCHLNTCPVGIATQDPELRKKFEGSPEHVVNFFFYLAEELRSYMAKLGFRSINEMVGRAEFLKVNDSLRTYKTANLDLSPILTPASSLRPGVASHCVSKQKHNLHVRLDNYFIEESEPALSNKENVVIDAQVVNTDRALGTTLSYHVSKRHGENGLPADTIQIKLTGSAGQSLGAFLAPGVSIELEGDANDYVGKGLSGGKLAIFPPKCSTFKSEENIIVGNVCLYGATSGKAFFRGIAAERFCVRNSGAIAVCEGVGDHGCEYMTGGRAVILGKTGRNFAAGMSGGIAYVLDTDETFKPKVNMEMVNLETVNDDERVAELRDLIEDHFHYTGSPLAGRILQNFTEYLPKFVMVMPVEYGELLMKARAAAAQANVPVEEEKVCEHEHKKVEPVLDDLEDSVLDEEAILARRAKLDKIKGFMKYKRRTDSYRNASKRTSDWDEINNRLTRPQLHEQAARCMDCGVPFCQSDTGCPIGNIIPKWNELVYKDNWKDALDRLLMTNNFPEFTGRVCPAPCEGACVLGINEPPVAIKSIECAIIDRGFDEGWMVPTPPLQRTGKTVAIIGSGPAGLAAADQLNKAGHSVTVYDRNDRMGGLLMYGIPNMKLDKKIVQRRVDLLAAEGITFVPNANIGVDVDANAIRAENDALIVATGATWPRDLKIPGRELDGVHFAMEFLQANTKSLLDSQLKDGQYLSAKDKHVVVIGGGDTGNDCIGTSVRHGCKSVVNFELLPQPPNTRGSDNPWPQYPRVFKVDYGHSEVKAHFGNDPREYCVLSKEFVSDGEGAIKGINTVRVEWTKDSAGRWAMKEIEGSEQFFEADLVLLSMGFLGPEEAVCKQLSLKQDGRSNIETPKGKFSVPNVDGVFAAGDCRRGQSLIVHGINEGRLCAREVDQHLMGSTYLPVAGGINQRALKNTVAATITVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y213</accession>
    <name>A0A162Y213_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_68548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295995.1">
        <property type="nucleotide sequence ID" value="XM_018441972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y213"/>
    <dbReference type="STRING" id="763407.A0A162Y213"/>
    <dbReference type="GeneID" id="29002878"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_68548"/>
    <dbReference type="InParanoid" id="A0A162Y213"/>
    <dbReference type="OrthoDB" id="5563539at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052292">
        <property type="entry name" value="Glucose_repression_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051:SF1">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD77955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="612" mass="66936" checksum="41D730C32AE3F95A" modified="2016-07-06" version="1">MPKKIAAEDDYERNIRSPEMCVDYLSYHFDEMDLAASWRVMTKQKKDIVNGLRLENASWRTWAKQKNKLKTVSPETLNWLKDSDVTWLYGPLHTVIHDQEDRYSKPKISSTQDTLGLITAPPPLTEQQTNPPVLRPEQSQAESTNTVNQQSQTNPESQPLTPTVAIEGGVAKQPEQQKENGQEKNTRRPLKSALKRVTMSDILKRSASEIHVDTLNSLGPDPSSLSITEANKQLGVFSPSVIATHRQPKLRFNQQVEQCIALSIDEKTARSRSNSQATDSSRLDNTDGQSGGEDPTNSTISGSNGAGAGPGTGGTTTTTTTSSSNGRQRPLFPRSSIKKIAPARLKNSSQSEHETDVSSLSSSASSSSTGHCGGFANIQTANSSRRNSYSSWDDNGDDDGDNLDDDDNNSSSNELMPAILNSTRPIRIQPPEGQAIRWEGQPCVYDVVPPSDMYQNNDDIEEDDDDDDDEEDDDWDTNDEEDNRILHEVVAGPSNLNSHHNQTIIHSSTTSTSTTTTATTTTTTTTAAAAATVQRATTSLPGPQISPKSPPLSEPSHYQTIADPQQANSSPSSYQAVADIHRMDQEQQRTSPSFISQVANWASSLIWSNSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y8V3</accession>
    <name>A0A162Y8V3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_141099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD79045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297085.1">
        <property type="nucleotide sequence ID" value="XM_018430526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y8V3"/>
    <dbReference type="STRING" id="763407.A0A162Y8V3"/>
    <dbReference type="GeneID" id="28991432"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141099"/>
    <dbReference type="InParanoid" id="A0A162Y8V3"/>
    <dbReference type="OrthoDB" id="2289697at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD79045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="145" mass="16426" checksum="F89437922C60DF60" modified="2016-07-06" version="1">MLSSASNTSSSLDADLNLLREATGSHTTWNQYTSDTHPFPDLQSMVLLAFVDGDNDMKSPFKLPRLDALLNYQTRKKSKIPVFPSTKVDIQLLENNTTSAYINLPSDHVRFLAANPKKARNMFSLPDRTPNQFICLQQGEKWRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y9W9</accession>
    <name>A0A162Y9W9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_162332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297295.1">
        <property type="nucleotide sequence ID" value="XM_018434602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y9W9"/>
    <dbReference type="STRING" id="763407.A0A162Y9W9"/>
    <dbReference type="GeneID" id="28995508"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162332"/>
    <dbReference type="InParanoid" id="A0A162Y9W9"/>
    <dbReference type="OrthoDB" id="9999611at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="139" mass="15473" checksum="7D0A11CA871F40E9" modified="2016-07-06" version="1">MIVQEEADVVGYEAQSNSQHQQHEAGGVGGMGGGDPYVDKITSSLWRRAAQIQSTLGSLTGKEDWEEAGRRKELEAQDMYREAQARAEAHEPSWAHGEYERWMGKLEQAVGHVSGDTDMEARARQRVQNGTDEVERATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YD99</accession>
    <name>A0A162YD99_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_106646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298045.1">
        <property type="nucleotide sequence ID" value="XM_018427955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YD99"/>
    <dbReference type="STRING" id="763407.A0A162YD99"/>
    <dbReference type="GeneID" id="28988861"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_106646"/>
    <dbReference type="InParanoid" id="A0A162YD99"/>
    <dbReference type="OrthoDB" id="412383at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF20">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD80005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="326" mass="34742" checksum="6D30CC49E7B3BE3D" modified="2016-07-06" version="1">MVLATQLTRILGIRHPIIQGGMKDVGTAELASAVSNAGALGVLTGLTQPTPEALRNEIRRCRTMTSKPFGVNLTFLPTIIPPPYREYAKVIIEERVPIVETAGNNPGEYIDMFKQAGVTTIHKCVAIRHALSAERMGVDVVSIDGFECAGHPGEDDIAGLVLLARAAETLKIPFVASGGIGNGAGLAAALALGAEGINMGTRFLCTAEAPVHQAVKEAIVRGDECSTALVYRPFRNTARIYKNSVAVQVNALERKPNASFQDIQPLVAGSRGRKVFETGDIDAGVWTAGQVLGLIHDIPTCQVLVDRTVKEAQDIIQKRLAKMCTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZI40</accession>
    <name>A0A162ZI40_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_183702</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:33731"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64743"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33732"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:33733"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the taffazin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD66921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284961.1">
        <property type="nucleotide sequence ID" value="XM_018438817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZI40"/>
    <dbReference type="STRING" id="763407.A0A162ZI40"/>
    <dbReference type="GeneID" id="28999723"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_183702"/>
    <dbReference type="InParanoid" id="A0A162ZI40"/>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00979">
        <property type="entry name" value="TAFAZZIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="13">
        <location>
            <begin position="135"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD66921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="316" mass="35343" checksum="AFEA5F1DA474423F" modified="2016-07-06" version="1">MRPLFFLRPGRLVKLGSVTASASVAYYVLKKHAEDTKNPAVGGGSDGGTTTGAAALTADYIPPPFYWETIPGFIKKKFEPPYPANSSAWNFMSSLVMGGVGSFGKFFIYCLNDTHTHNMQPTLDIIDQENRARGLITVSNHASVWDDPFLWGVLPTKTLFSVDKMRWVLGAADICYTSLFKSLFFSLGQGIPTIRGAGVYQPAIDFAIHKMDQHQWIHIFPEARVNQGDDLIRFKWGIGRIVMEAKECPIIIPGPFVQLFNPITVVFGEPIDVQDVLNEWQQGKLSEEEARIRITSIVYEALKKLKEDAENNRLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZNP2</accession>
    <name>A0A162ZNP2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_188800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286111.1">
        <property type="nucleotide sequence ID" value="XM_018439564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZNP2"/>
    <dbReference type="GeneID" id="29000470"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_188800"/>
    <dbReference type="InParanoid" id="A0A162ZNP2"/>
    <dbReference type="OrthoDB" id="2327125at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007841486" evidence="2">
        <location>
            <begin position="28"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD68071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="345" mass="38690" checksum="9A9181CD3650386B" modified="2016-07-06" version="1">MSGLSLQHLIGATYLLAACFGISGANADWWMTDPQDTPARWYNKVYEIPTWVMPIKDYNENTFLAVTVFSVALVTLSAIYANFYILRVYLPSAPEGKRNIGDLNTDILCYLVATFFTTFSFLLLSVGKIWVSFGVFHNLFEFLLLAHILLRQAGISKRFFTLAGFAYLMTTFGIVLVLPWPFDAVYFKFQGLVIDVVLSVTMIRLYKHNRAIAEKTNIRTPANIQETGAENGILPEPKDSKDKKVVNFLPPVHENIYLLVVAAVVHLLGNTLVTFSNTFSLWVIFQFSYAITFPLYAYFVVSEPDSSRINWYKVEFAQEALVIVLGFIVSGLCIAIGAVTSGVSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AA21</accession>
    <name>A0A163AA21_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_79244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290101.1">
        <property type="nucleotide sequence ID" value="XM_018443446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AA21"/>
    <dbReference type="STRING" id="763407.A0A163AA21"/>
    <dbReference type="GeneID" id="29004351"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_79244"/>
    <dbReference type="InParanoid" id="A0A163AA21"/>
    <dbReference type="OrthoDB" id="2442703at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="403" mass="46136" checksum="5DC30B126ADA566D" modified="2016-07-06" version="1">MSSLVKHSSESSEEVTTSRVLTRRASRSAHSGSPIMNPKDSLETEDPSSLSPDHIATTSSANARSQSADSINEPQPRKRRRKTKAPIYKKKETHSKAPGRDDTDRETRHTSQRMSKEAREAKRAERDAVIKERLAELDKIEKAVKDHSHPDYHRLMEDMKVKHEQKRLAIESRHDLIEMNIKNALTCQHKMAYDQFYWDKLALRRSMIQQVQQKINILEQEYYSHGQGALDNQHLTEWVPPERPLMINILFPSYSITANEKYFANYHFVSLNSPPIRSEIVGLSEDEANNDLQLARASSPKSSASVSPDMVYASYHYSSHTASPPQPAHPETHHNSNNHKESPHTTSTQQQTPPGLVSPPLDIVDPYHQTYHDPLRYERNDPTREPQVKLPPLRPWQFDSSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AE00</accession>
    <name>A0A163AE00_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Copper fist DNA-binding transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_113290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290861.1">
        <property type="nucleotide sequence ID" value="XM_018428338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AE00"/>
    <dbReference type="STRING" id="763407.A0A163AE00"/>
    <dbReference type="GeneID" id="28989244"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_113290"/>
    <dbReference type="InParanoid" id="A0A163AE00"/>
    <dbReference type="OrthoDB" id="5600085at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD72821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="59" mass="6867" checksum="6AB0EF5D8BC7B6C9" modified="2016-07-06" version="1">MSCIRGHRVKRCQHHDRKLVPITKPGRQISQCSHCRDLRLTHKTHVKCNCAIAQGKEYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AM33</accession>
    <name>A0A163AM33_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_133330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292471.1">
        <property type="nucleotide sequence ID" value="XM_018429564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AM33"/>
    <dbReference type="FunCoup" id="A0A163AM33">
        <property type="interactions" value="357"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163AM33"/>
    <dbReference type="GeneID" id="28990470"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_133330"/>
    <dbReference type="InParanoid" id="A0A163AM33"/>
    <dbReference type="OrthoDB" id="295656at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="197"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD74431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="438" mass="49072" checksum="64DF62E2926BA33A" modified="2016-07-06" version="1">MDISARLKECIEIPQQKEKLDAFRSVLNDVLSSSQGPQQVNSLEEYVKAVLDVQVGLVIARQLLSELIELLDARITDRDNRKKLLLYAIGQAQLRAVSFEEQLSQMRSKLADIYTEEEDFLEAARTLQGISLDSGHRAISDDFKLDIYIRIVRLLLEVDETISAETYLNRAALLLPATPDPARGLIFKLSQARILDAKRRFLEACQKYHELSYDSQMDEEERIFSLSAAVQCAVLAGAGPMRSRTLATLYKDERTHHLPSFPILEKTYLDRVIRPEEVSDFAATLKPHHLARLTSNTTVFDRAIIEHNLLSASKIYNNISFDELGVLLNVSSEQAEQAASHMIGENRMVGSIDQLDQLIYFESGGAAFDQSGDDNVISAAAAAANGTTSTNQRLEQSMLEIAKWDSGIQNLCQDIDTIVTLIQERYPDYASEHFNAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AVB5</accession>
    <name>A0A163AVB5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_143054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294111.1">
        <property type="nucleotide sequence ID" value="XM_018430927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AVB5"/>
    <dbReference type="GeneID" id="28991833"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143054"/>
    <dbReference type="InParanoid" id="A0A163AVB5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="89" mass="10055" checksum="5D88CFF8E1F33F2D" modified="2016-07-06" version="1">MASSTNFVPPILHLLQSPLSTSHLLRGVAATNHHSHRLSMLGNSINIRNDRCVVPEFLLANQDDDYTEFSFENDDRSDFLLLTKELEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B9Z8</accession>
    <name>A0A163B9Z8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_162203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297161.1">
        <property type="nucleotide sequence ID" value="XM_018434583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B9Z8"/>
    <dbReference type="GeneID" id="28995489"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162203"/>
    <dbReference type="InParanoid" id="A0A163B9Z8"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="537" mass="61135" checksum="AE2DAC997EC46F63" modified="2016-07-06" version="1">MNPLNFQIPRRRGNDTISPFPKRRRTEANDQLLNTASLFDKLKKEPLLEDVWAKEERALEELNENSEESQPIVDVASQFLDKEVSERLAEALSRNDVSDDSEPPSTRYFFTLPTKTSIGEWPMDSRDGAGVAKAEFIHKLTQTTQGRSFMLESGCLKHWHKRGWECPRSLYKYLFEMGKYINIYIFMGVLMCSNMRFVIVAFEPNKVKMESDVQYSDYPVGCIEPEWLTSIFEAYGRAPQLITKFASKTTPTPISTPISTPASTVRPTPEFEPELISKSKVPQSSLGWIIELFGISIKQWPSAYRDNIDQLLGLLLDTSLDPTSRPALGALQTTIQGCLDLLEQTTWKKTLAEFDIDYKKYSEYQLLYCIQAIPPTNKRGVFFQQCLAAKGLGLSRDHDKLEDVLKLINDPDGMFSSSQPDYSLLAIKIRLLDIFIGSDEDELDLEKDTVQSLIQSLQLLSRKIGGRLGTLKRTVANECAQRLWNKLAYTIGRDERVIEDHQLCLWFGGTLGCQTIQDNIYIDIICHIKINLSVLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BCM1</accession>
    <name>A0A163BCM1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_161288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298691.1">
        <property type="nucleotide sequence ID" value="XM_018434373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BCM1"/>
    <dbReference type="GeneID" id="28995279"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161288"/>
    <dbReference type="InParanoid" id="A0A163BCM1"/>
    <dbReference type="OrthoDB" id="2290433at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="158" mass="18146" checksum="8FD02F46178F12C1" modified="2016-07-06" version="1">MAIVRPELMEQGKLIMSRFEYTIYELPVLSSTILLTIGALTTVLLAGLWLYLSCRSKYRNHEDGDDEERQTLLPSNLCLRRTATYYQWNRSPPTPSKCFASPMLQHSKTRSLQKSQNQLIKSRLTETWEHRRSALLKKYAAVTGSDDAEGDKKAMFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163D0A2</accession>
    <name>A0A163D0A2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_151311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285820.1">
        <property type="nucleotide sequence ID" value="XM_018432662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163D0A2"/>
    <dbReference type="GeneID" id="28993568"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151311"/>
    <dbReference type="InParanoid" id="A0A163D0A2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="311" mass="35679" checksum="96A4CC0D55DD2B2C" modified="2016-07-06" version="1">MSRNLNNNSVNNAFGEELSVGRMIMLQHSQGTVSNQRRLAPKRARLNLEGDLSGRTGNIHDVYEKLDTMNSVLNTVLMNTLSEKAEATASNAVEQDMLPGRQPTLNQLLCDYLSEEKLYDQYNTNENKNGEGNRLVLKSVTNYLCCQDEGKKVDLPTLRTKIVRHIGNRKLQEKKTGEKKQEENRWACLCQRRVKSCERRQSTLKANWGHFVNSFGENVNSILHADYMPDLESDDEREEEKQDSSSEKSFFLEIPPKLEKQRGIGDRFVDELDADYEAAHDKKNNTRPFEHKFKGIRDKQLSKTKANKLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DEN2</accession>
    <name>A0A163DEN2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent Clp protease proteolytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_19530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).</text>
            <dbReference type="EC" id="3.4.21.92"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288790.1">
        <property type="nucleotide sequence ID" value="XM_018439705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DEN2"/>
    <dbReference type="STRING" id="763407.A0A163DEN2"/>
    <dbReference type="GeneID" id="29000611"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_19530"/>
    <dbReference type="InParanoid" id="A0A163DEN2"/>
    <dbReference type="OrthoDB" id="2017408at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000001">
        <property type="entry name" value="ATP-dependent Clp protease proteolytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001368">
        <property type="entry name" value="PRK00277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009205">
        <property type="entry name" value="PRK12553.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF11">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD70750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="216" mass="23911" checksum="C2EC3473E19F89E1" modified="2016-07-06" version="1" fragment="single">ESPVAQSVIPFVIEQTGRGERSYDIFSRLLKERIICLNGPVNDNVAAVVVAQFLFLEAENPEKPVSLYINSPGGSVTAGMAIYDTVSYYKDLYFYIQSPVSTLCNGQACSMGSLLLAAGKPGKRFALPNSSIMIHQPSGGAAGQASDIAIHAREILRVRERLNRILQKHTGIREIETIEKMVERDYFMSAEEALSFGLIDKVLEKRTEQKDLLKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DWS6</accession>
    <name>A0A163DWS6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_168305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291920.1">
        <property type="nucleotide sequence ID" value="XM_018435835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DWS6"/>
    <dbReference type="FunCoup" id="A0A163DWS6">
        <property type="interactions" value="380"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163DWS6"/>
    <dbReference type="GeneID" id="28996741"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168305"/>
    <dbReference type="InParanoid" id="A0A163DWS6"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19076">
        <property type="entry name" value="AKR_AKR13A_13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD73880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="317" mass="35143" checksum="2423054F105AD0F1" modified="2016-07-06" version="1">MIQLREIGKTDVLVSSIGLGCMGMSEFYGPTNDEQSAKTLERAAELGSTLWDTSDAYGINSHNERLLAGILKTQRDKIFVATKFGFVRNKDNEFTGVSGSPEYVREAFAKSQKRLGVDLVDLYYQHRVNANVPIEETVKAMAELVNEGRVRFLGLSECSAETLKRAHKVHPIAAVQIEYSPWSLDIETNGLLDTARELGVSIIAYSPLGRGFLTDVLFLAFFPENFDKNIKLVDGITALATKKGVTPSQYVLAWILAQGPEFIVIPGTRRVKYLEENAKAGEIVLSKEEVAEMRDLINNADTIGNRYFPAFLSLVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163E1U5</accession>
    <name>A0A163E1U5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_158501</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292770.1">
        <property type="nucleotide sequence ID" value="XM_018433800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163E1U5"/>
    <dbReference type="FunCoup" id="A0A163E1U5">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163E1U5"/>
    <dbReference type="GeneID" id="28994706"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_158501"/>
    <dbReference type="InParanoid" id="A0A163E1U5"/>
    <dbReference type="OrthoDB" id="205166at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="195"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="78"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD74730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="259" mass="29797" checksum="3734DA55DBC98855" modified="2016-07-06" version="1">MSESMLKTRLAMDDRPVKNLEKKVSSWLAHLPNESIESAKSNCDALLIQISNYQTSIERHPLIQEANTKDITKYADIVEDTVKKEAEARDQISDLKEDLKKAQKVRDNKLEYDQVAREILKLETREAYHESIAQLQSDIDMLRREKLNKEEALSSRKRKFGEMIDIVKRLQKDIEEERARGHKTQKILMDMGRDYESSDDESIHGDDHESSPEADALGTTGNFHRFQERDNDDDDEEGEDEEGMVPDGEDGAVVFNEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EAP0</accession>
    <name>A0A163EAP0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CCHC-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_164576</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295720.1">
        <property type="nucleotide sequence ID" value="XM_018435037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EAP0"/>
    <dbReference type="GeneID" id="28995943"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164576"/>
    <dbReference type="InParanoid" id="A0A163EAP0"/>
    <dbReference type="OrthoDB" id="2214613at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD77680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1151" mass="128666" checksum="E8161F0495EA687A" modified="2016-07-06" version="1">MALSTNTPEPPAVKNPSTTGSSPPLPTSFTPISPSSTPLYSQVATQNALSLLEKQPHVIFSSTNNTTPRTWRVGSSKFSVFFTVPPKSSPKFDPFWRALLSAYPREVNMGITLGSRSSPDTCELHLPTSADCERACSRPLVVGDSSFPTQPAVPIGTIVRRVFLTKLPRVPYHDLATQLAKCMFPFGKVREIAIHESYGFFDGSGYVVLANTPTDDVPSDSLTYQIAYDDTQKILGKWPSMGSHCTYCKEMGHDVAKCTKCPAETRTCFGCNKTGHLQANCPYITDPSKTSKTSNKRSRHPNRNSKLDRPIIAPKPLIPTELSLIYGGSEASKHNPRQPALRELSKLSPTKTTFTLPTPTEPPTSSGPRPRSRSVDTPTRGWDKEIDDRMITNLMDRDEARALRLQGLPKVGHPESRSFFIRHLRSQGIDILALQETHASSSMLQSTFDQQFRSSSSLWSPYCGVVCLSPHIIFTDPLFSPCGRCIMTTITHVDNNFSPFRIGAIYAPASQTPRYRFLASLLSTPDLIPPNPSNFILLSDFNHAIHSHYALGRRAPADWLQFIDTNMTDCITPRGQHPQPTFHRALSSTTIDYILASSDLHPRTTDPQVSYIHQKWSDHCLVAVSLSLPSTKSSGKGLWRANPHLAQSLSFRTDLNTLLSTLVPALRADLSPQARWDAIKLEVIRFTFCSIHGSRSLSFRGRATIMNSLVLSQLWHVLRVVSFPSAFLDRVRSIVRGFFRVNSFPPIAFDTLCLPRLQGGLGILDPGIQQCALQLRWLKPLIRNPLLPHGLVPQWFSTLLRSDVPTVDPLLPLLFPDCRPRNHRTLDSPLNLVLKAMDTLPRNFDRVVLNLSSCLILPLSSMISSMPSHPPYRPAWRDLRVHHLYQIESNLDILTPITPSRPLPRSVTLNRILNRIRDHTMVLHPILFRACILSFVLAFQQPDLPIRDGSSIDLQPLLSAQLPGQTWSRLTTRSYRSACSHQLSDARPIHPPLIPRQPRSFWSFALPHRARNVWFRGLHNKLSCRALLYRIMPSTVSSPLCTICQVSIETQEHFLLACPLKSAVWTGIWLEFFGTVPLPSVLSNAFQSFVFPPTLNPAIPASSVFGLTILAIWDHHWSFHFNSIPFLLSAVLHTARKSISHLCSELELDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EQL2</accession>
    <name>A0A163EQL2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_161506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298910.1">
        <property type="nucleotide sequence ID" value="XM_018434421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EQL2"/>
    <dbReference type="GeneID" id="28995327"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161506"/>
    <dbReference type="InParanoid" id="A0A163EQL2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="349" mass="38801" checksum="9087EBB84D9A611D" modified="2016-07-06" version="1">MYNILLDSFQTMVNNCQSIAPAPSPEYTELLRRLTAMEESLKTMDSNIGIVIKGNKDSLEILDSIANASGELLAVIVPTTIPASASVPFAASSIGSTLDWYTTPSEAFFGISSAAPSVAPSVAPSVGPVVLTGANAGELSKQDCTRVLALIRGESKKHNFKSNKLELVAANDSKRSWDVNVDYRLPPNRQLMHDLHAYLAPKANISNCIYTNFCGTRRRVKESYEARKKTNSRSRKAGRETDHFDRRELTYHTFKAEIDMKVGKSCDGLLQKEAMSEGESEDDMPGVSSNHAIRTYNHFLAVVNDFMRNRMDFNSRQMLKRSFGRDAVLAVPPRLTSLLPHWAFRDEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ERB0</accession>
    <name>A0A163ERB0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_161652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299060.1">
        <property type="nucleotide sequence ID" value="XM_018434440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ERB0"/>
    <dbReference type="GeneID" id="28995346"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161652"/>
    <dbReference type="InParanoid" id="A0A163ERB0"/>
    <dbReference type="OrthoDB" id="2276048at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD81020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="471" mass="54568" checksum="35E8ED10E1779F41" modified="2016-07-06" version="1">MNKKMMMYSKKIELPKTVCCKYFKENLTHKQKDRQSRAIYKDTITKIKNLPGTSIEMKEYLDTLVHEVNIQADNQYINYGYIESQGPTNITIIRGKKRRVSKENDSSRNPSDNKDSSDSDSSYQRTPVSPPSVSLHSSQLEELDSFVSDKSDSTYLTEESKPYGDILKTRKYILTLNEVDAGDNDGKEVYNYDTNSSLCERLNISSICYNADSSDIYELKPEVLDDDEYKKMKDWRMKVKKCQLYFPPAAATPKQLHLNTFLCTLTDTIVHEKSQQERKSEIGFTIDHVSPLLKYIFPAKGVLSCKWERSSTLQASTACKKVRTDLILIANGQEVGCGEIKTPCPTSQLLEEDRSRIAETLKRQLHARIMKSKDVKEFFTFGIIFDGFNIELYMMIFDFQRTLPYQFYYVERVKLPTSFESYNNMEETIEYLLSFKNLILSSLAGEEDMHKPYAYHNFTRLFKPTIAFIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167J6J9</accession>
    <name>A0A167J6J9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_153530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441029">
        <property type="protein sequence ID" value="OAD65288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283328.1">
        <property type="nucleotide sequence ID" value="XM_018433177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167J6J9"/>
    <dbReference type="GeneID" id="28994083"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153530"/>
    <dbReference type="InParanoid" id="A0A167J6J9"/>
    <dbReference type="OrthoDB" id="2273311at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="46521" checksum="BA25A557B11858EC" modified="2016-07-06" version="1">MEQFLQHHMFPPIKLATLCLPSISGGLGVFDPIIQQSALQLRWLLPLVCSPFGQSGLVLPWLSFLLWSFSGILDPRLPLLFPDLRPLPFRHIDSVFRNIFAAIDLLPHFFDSISINHPTYLSLPLPSICLPSSLIPRTWRHLLVTDAFVVDDSLQVLCHQTRPKCPQSPRIITKFFHQVDNHSVLLQPFFFRSLLLHSLLDGLLPPPSSPIVLHVDPSPFLTSMFPIIPCKPFLPKTFHTLCTLSPDNPIPPLHTHQRCTFWSTSIHHSVCSLWFRTLHNKLLCCSVLHQTVPTIFPGGSCPICGDIKESTSHFLFTCSPKFSIWTMFWSTHFGNVPSMQDIHSALFFLCLPPSLTPDILAVSFVSCILLTIWCHYWSFMFDNAPFLSTSVLVTAASFVTSFHAKLSLPLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167J7V0</accession>
    <name>A0A167J7V0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_72427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441028">
        <property type="protein sequence ID" value="OAD65437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283477.1">
        <property type="nucleotide sequence ID" value="XM_018442654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167J7V0"/>
    <dbReference type="GeneID" id="29003560"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_72427"/>
    <dbReference type="InParanoid" id="A0A167J7V0"/>
    <dbReference type="OrthoDB" id="2273311at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="27046" checksum="98E50526C7195147" modified="2016-07-06" version="1">MLIFFTLLDVLHMTPLPLDILHQVRSCGYQFLMHQMFPSIKNDYFSVPKKKQESLVSVGQGLGTSKGHSKVMLSDAFIYDNILCCLHHLLPSEVVRFCNHISYFRKSHQRGLLLLIGSQLRDCIPDPSPTNTIQDIGRIDLSHVLDITPKIFRIIVFSVPSPTTFSPVISLAKCKFFWCMVIHHSSWNVWYRFLLDKLSCRFCLNEILPANFPYPKCRLCQNTSNIAAHFIFLCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JSN1</accession>
    <name>A0A167JSN1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_152171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441001">
        <property type="protein sequence ID" value="OAD66626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284666.1">
        <property type="nucleotide sequence ID" value="XM_018432862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JSN1"/>
    <dbReference type="GeneID" id="28993768"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152171"/>
    <dbReference type="InParanoid" id="A0A167JSN1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="101" mass="11206" checksum="EFCDB697B4DAA3E4" modified="2016-07-06" version="1">MTHNVFYVMTLKMTNTHSEYVFVKKNWHQITTRFLDTSASLKFDCLLPLPYSPQSVKARNTTVPSYIVLGCTLGAKWEAAILGDGGNNTAQFKVTSSPMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K4X1</accession>
    <name>A0A167K4X1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_77484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285330.1">
        <property type="nucleotide sequence ID" value="XM_018443261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K4X1"/>
    <dbReference type="STRING" id="763407.A0A167K4X1"/>
    <dbReference type="GeneID" id="29004166"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_77484"/>
    <dbReference type="InParanoid" id="A0A167K4X1"/>
    <dbReference type="OrthoDB" id="2244878at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="446" mass="49704" checksum="583807C3CC5B83D4" modified="2016-07-06" version="1">MNEKLDPSVPYPGQSQPFLQPQPQPQPQLQPQPQSNKARRIVQGLLLGAVVGLFAVSQWTSIDLNPFKPIHQDSPSDLSEITDLQGPADLSHFMESLQDSFGGCHGELYAPDYEDEYGRLHSIDSLDDCSGKNSILEHCKQNIAFPPRELQNLGRPPRRHEHFCKPEDLHSQFNVFSFSPDTFKHASVILEGHFSRGGHVVIEKSTSSHVEDVQINVTLYAGRKHLFDQVSLTGFDNEGNYTVEIKRAKDSKRRESSHKPPVKADCLIFKISVVLPTHLDKYDSLSLHLRSASRVSGKGLDGIEFDTFRAGVGQGAIIFDGLKAKHAQLGVLYGVVMGTYQPSERFEAGTIRGATQLTVEPQADNTNITVASVFGRAVADIPSDYYQGNFLTYSWSTPPTIEAAHPEDLHVTEYKYTLKKGYFKKQDTESNVVVHNKHGLTKLHFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K669</accession>
    <name>A0A167K669_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome maturation protein SDO1/SBDS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_160457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285397.1">
        <property type="nucleotide sequence ID" value="XM_018434182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K669"/>
    <dbReference type="FunCoup" id="A0A167K669">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167K669"/>
    <dbReference type="GeneID" id="28995088"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160457"/>
    <dbReference type="InParanoid" id="A0A167K669"/>
    <dbReference type="OrthoDB" id="2567806at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="95" mass="10335" checksum="A45930A549600CB7" modified="2016-07-06" version="1">MSGSTNENSAKIILKANDQEFFVIASPHMAAKWRNDKTIPLIDVVQNFDVFTTPSGSITGEFIRPSKGTLESAFGTDSVDTIVKKIVSEGTEQPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K6S3</accession>
    <name>A0A167K6S3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_137011</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285420.1">
        <property type="nucleotide sequence ID" value="XM_018429827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K6S3"/>
    <dbReference type="FunCoup" id="A0A167K6S3">
        <property type="interactions" value="583"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167K6S3"/>
    <dbReference type="GeneID" id="28990733"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_137011"/>
    <dbReference type="InParanoid" id="A0A167K6S3"/>
    <dbReference type="OrthoDB" id="41266at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04105">
        <property type="entry name" value="SR_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="146"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD67380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="230" mass="25442" checksum="2E976A469D560DFE" modified="2016-07-06" version="1">MSIEVPIVYILAGIVTLLAAVVASFFLLKKKQTGDTILLLGVSDAGKTALYTLIRFGKKALTVTSMKENEGSVTLGNKTFGLVDMPGHERIRYRYSEFLPVARGIVFVVDSTTISRQIRSVAEYLYNVLASLEAQNRKLPVLIACNKADMITALPKDKIQTLLEAEINRLRGTRTAAVEQQNSEGDDQEGFLGYEGEAFKFEHLESIVDFEVCSVQKEEIDSVTGWIESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KG19</accession>
    <name>A0A167KG19_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Replication factor C subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Activator 1 41 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_150693</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286059.1">
        <property type="nucleotide sequence ID" value="XM_018432535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KG19"/>
    <dbReference type="FunCoup" id="A0A167KG19">
        <property type="interactions" value="387"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167KG19"/>
    <dbReference type="GeneID" id="28993441"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150693"/>
    <dbReference type="InParanoid" id="A0A167KG19"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000011">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000032">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000237">
        <property type="entry name" value="replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="66"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD68019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="357" mass="39806" checksum="8642730C3F9A5AA5" modified="2016-07-06" version="1">MASRNFFQPTSAFNGGVTSNLGIKNKKDSNAEIKPWVEKYRPKNMSEIASQDQAVKVLTKALTSDNLPHLLFYGPPGTGKTSTILALAQQLYGPKLIKSRVLELNASDERGIQIVREKVKNFSRTTVTQTVSDFPCPPYKIIILDEADLMTKDAQSALRRIMETYSKTTRFCIICNYVSRIIEPITSRCAKFRFKPLPTDDLVNRINMICDKENVQLGQGTMKALIKASSGDLRKAITFLQSGSNLHSNEPITPGTIYEMAGVVPEETMKTLSDAWESNDQQKVLDAVQYIINNGFSAEQLVIQISEEVTKNERLSTLQKAQISQVLGEVDLRLIHGADEHLQLLHLMSQVTSIVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KNM6</accession>
    <name>A0A167KNM6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_79336</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286549.1">
        <property type="nucleotide sequence ID" value="XM_018443454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KNM6"/>
    <dbReference type="STRING" id="763407.A0A167KNM6"/>
    <dbReference type="GeneID" id="29004359"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_79336"/>
    <dbReference type="InParanoid" id="A0A167KNM6"/>
    <dbReference type="OrthoDB" id="2020758at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02662">
        <property type="entry name" value="Peptidase_C19F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="55"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD68509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="581" mass="64423" checksum="39ADD416DDA7C125" modified="2016-07-06" version="1">MASSSNYHLSAIAAVTSIALAASGYALSTSISDSKRRRRRIATKIMKERDGKYIQGLINTGNSCFVNAVLQALATLTCLRSYLAERVDDPAEEPGDAPVTRNEAILRSVAYALYTTVEMLNRPLARPRSALPTDIIEALERKTKGTINRDQQDAHELFQIITSALTAEEEDQYNPRATSLFDPTALRQMTLETEALTNNAMENFETSSMSSIGTMGSMWSSFSVSTVGGHLHPRSRRPRNPFTGLAASKISCMKCSYTAPIRHHTFDNISLTVPQTSSCTLENCLDTYTKVDTLTDFQCRKCVLISTAEALSRELDLQRSQVENGTGSPERIKRLELDIHRLKDAIHFNVEASLKGISLQPPAEMANTTKQTMFANPPKALCLHLSRSVYHPSGNIQKNHCNVKFSEFLNLSPYTTNGFLNTGDPSAALSSHNVSGGSSARLMPSPSRTSRTSLVYLRNMAGGQRFVHGRDGLNVALKSKDEDDQRIIRNALPSMTLPSLRGIQYRLSAVVVHYGGHDSGHFITYRRKKLPTGLDIRSPLETNDSRPPTKFWRCSDQTIEEVDINVVLESEAYMLFYERDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KV62</accession>
    <name>A0A167KV62_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_172795</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286999.1">
        <property type="nucleotide sequence ID" value="XM_018436872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KV62"/>
    <dbReference type="STRING" id="763407.A0A167KV62"/>
    <dbReference type="GeneID" id="28997778"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172795"/>
    <dbReference type="InParanoid" id="A0A167KV62"/>
    <dbReference type="OrthoDB" id="7464992at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF18">
        <property type="entry name" value="PEPTIDASE M48 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="9">
        <location>
            <begin position="213"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD68959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="486" mass="54240" checksum="78B10188CAFC3346" modified="2016-07-06" version="1">MWRRTLSKSLFPVQSTTRLLLPRYTAPRCISLPSHFSTSSRPRCLSIQARPQKSRIYSTPTFIRSFHASPSNKVPIIPLPAVIGALLKSGKLVSLVSLSSKTSMTLLPHSIGKGRAKWVVSLLAGIPIIGVALLLVVGLDQAPNTDRVRFVYLSEEEEAAQVKKEIGGLLDSISGLTVSKDSEYIEWLDTIMENLAKVAVDDIRDPVRDYSETLEGKTPKKFTVDVIVDGSTLNAMCAGTNVIVYDLMLQLYGFNTDQIAVILSHEMAHSLQRHFVEQNGLVSFLTMLVDITRGALWMVTESFGPYVNQKINDTLNGYIQLHTNLSYNRLLEKEADLVGLKLLAKAGYDPRAAIEVWTTMADIEKTIKKTVEDGDNKEGTSTESLHADPPETFEDLSESLLSAWFGETHPASEDRVTYMKEHMDEAIAIYEESIKINGQPKAYILSQFRKEEELITIQTESLMQKLKSKVNGLFWWWSTPVTASTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KZD7</accession>
    <name>A0A167KZD7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_149629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287266.1">
        <property type="nucleotide sequence ID" value="XM_018432309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KZD7"/>
    <dbReference type="GeneID" id="28993215"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149629"/>
    <dbReference type="InParanoid" id="A0A167KZD7"/>
    <dbReference type="OrthoDB" id="10420056at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="173" mass="18968" checksum="5C7D513B0443F74E" modified="2016-07-06" version="1">MGSDRPLDEAENGKRISKKKKTSANTITTTTLPPFQANTSFTMQLFTIQQHLNSKHQIHQTQAPVSKRSTKTPTKRSTNRVITLTSSMSHCIRNLSSVKKVFGCKGSKKTVASSIAPSPYSFSGNSCIPGVPCESEYSPSSRRLSDRSMALDSLIFDHPSVTICLRPAAYRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L2H7</accession>
    <name>A0A167L2H7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_66341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287478.1">
        <property type="nucleotide sequence ID" value="XM_018441629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L2H7"/>
    <dbReference type="GeneID" id="29002535"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_66341"/>
    <dbReference type="InParanoid" id="A0A167L2H7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007889657" evidence="1">
        <location>
            <begin position="22"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="175" mass="19700" checksum="696F3A5A0678039F" modified="2016-07-06" version="1">MSSLNIVLLNLRLVMLETAYARLEARFEARFEGGEAATEQPVRGNPPDVNHLQPVVGGNTIPRPSPQEQPNSWVLSAGSVTAALVLHFTRGNTKEARLLYSAIGRLARQLVQLYHRGVVLHLTRETSWLETLRREQPEEILLLIGLRIPECLSLCFLRDRELLSPVEDSNKTDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L4W1</accession>
    <name>A0A167L4W1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_135708</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287637.1">
        <property type="nucleotide sequence ID" value="XM_018429742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L4W1"/>
    <dbReference type="STRING" id="763407.A0A167L4W1"/>
    <dbReference type="GeneID" id="28990648"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_135708"/>
    <dbReference type="InParanoid" id="A0A167L4W1"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14500">
        <property type="entry name" value="PTP-IVa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000086">
        <property type="entry name" value="Protein tyrosine phosphatase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="5"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="77"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD69597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="185" mass="20716" checksum="BA806E1425F1DC63" modified="2016-07-06" version="1">MLSLIDSPNSPIRFLILDCPTESTLGYYIDEFVQLSVATVVRCCQPTYSISRLQEHDIQVIDLPFKDGGVPPPQVVREWLALVEQARDQEDQQTIAVHCVAGLGRAPVLVAIALIEMGVKPLDAIEFIRTKRRGAFNKPQIAYLDTYKRTMKPRSSGSHYSLRSSLERMFKFGGTKAVTPVSQHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L5N9</accession>
    <name>A0A167L5N9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_172282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287689.1">
        <property type="nucleotide sequence ID" value="XM_018436764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L5N9"/>
    <dbReference type="GeneID" id="28997670"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172282"/>
    <dbReference type="InParanoid" id="A0A167L5N9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="238" mass="28803" checksum="1479008B8B7DC469" modified="2016-07-06" version="1">MRLVFRHKDNNAPESIDRCFIAIQSLKCLNIFTSKHKQTMVIDLYRTCNSGTFYCTFVRRSGYNKHTRVSGYDGVVWLTVSSKKNERHSQPIAALYQEILRKKKTNGEIDESKFETRWTSGVEKSRVHQRTRVFSTCMMMMVTGYTSIWLWLPYIDSIKVFFIRIRWWWWWWWWWYLSICDNAQRHQNSFSPMPQNGNLETKDLKLVYSDRNFQYTECASRQLLAIQFIDFFKVYLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L8D0</accession>
    <name>A0A167L8D0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">sphingomyelin phosphodiesterase</fullName>
            <ecNumber evidence="2">3.1.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_182632</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.12" evidence="2"/>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287858.1">
        <property type="nucleotide sequence ID" value="XM_018438650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L8D0"/>
    <dbReference type="STRING" id="763407.A0A167L8D0"/>
    <dbReference type="GeneID" id="28999556"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_182632"/>
    <dbReference type="InParanoid" id="A0A167L8D0"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09078">
        <property type="entry name" value="nSMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017766">
        <property type="entry name" value="Sphingomyelinase/PLipase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF1">
        <property type="entry name" value="SPHINGOMYELINASE DDB_G0288017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="6">
        <location>
            <begin position="160"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD69818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="488" mass="55157" checksum="6CB19C220414D3B9" modified="2016-07-06" version="1">MASVQHYQAHEMSELATSDEFNDDYPSNYPSSYPSSSREGAPLLGDNASQESLLSPTSTLAPTLQHKPSFFNRLRSLFHRDNQARFGPIDSESGPENNSTLKARKSRGCGVRISGCFVCLLVSGLALFLFLLTSTLYLSPASLPPTRLPDKSTNTTAQFLTLNIFMRPPGVKNNADDYKDERLDYIIRYILPEYDVVAIQEAFAFANRRIDRLIREARYLGFNYHVASPRHYPWELAADGGLLLLSRFPIKQSDVLEFPRGLHSDWLSCKGALHALIELNATRRIHLYTSHTQASYDVQGAFNEEDTRMRYSQFGLLHRFIHSTTAQDTDPILLTGDLNVDASAHNQSTPTASSKAYTQMMDILSGKGVWDTSLHETMWNDTWRVDWKDMGYTTFGHHPVTFGDKLIVNHTEVPAETALTHTDQWMTLQSLDRILWASRNTTELAIHNVTIEPFAVRDNTALTKQQKAKMHFSQISDHYGMSCNVQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LH83</accession>
    <name>A0A167LH83_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GPI transamidase GPI16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_182393</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288489.1">
        <property type="nucleotide sequence ID" value="XM_018438611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LH83"/>
    <dbReference type="FunCoup" id="A0A167LH83">
        <property type="interactions" value="299"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167LH83"/>
    <dbReference type="GeneID" id="28999517"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_182393"/>
    <dbReference type="InParanoid" id="A0A167LH83"/>
    <dbReference type="OrthoDB" id="331263at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007245">
        <property type="entry name" value="PIG-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959:SF11">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04113">
        <property type="entry name" value="Gpi16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007889889" evidence="3">
        <location>
            <begin position="20"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="564"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD70449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="602" mass="68420" checksum="8773A57F37B96D40" modified="2016-07-06" version="1">MRAIIKIVGLLGFLNAVSARVHPTEEFLDEELTLTPLSDGKLLAHFEFTTNVQAHTDPNAPFLDYGLFPKAIGQVLQEYDVQEMHLTFTQGRWNYEEWGYPPEQSAGTGVELWAWMKNSNKIDANWRSLTNVLSGLFCASLNFIDDTLTTQPRMSFLPEPLSQSDRESHHHQYINNDNDNDNDNRSSSSIHAEDQIKSIQRDSQLRYGALPHENVCTENLTPWIKMLPCKAKSGIAVLLNAHKIYNSNFHAMGIVARSMCRDEACSERVLELRQTVTSVLDPVRDTGRRDWSLETIFERTLKGSCPLARQSRVLVNMDGVNKERELKPSPTLIRDEHTSENTQIAVYDLHQSTQPLDVRMSWSEPVFKYPLEPIHPVVSAQRYFTGYGQERGGLRITIHNRSPDKSIPVVYYESAPWFLKFFLHTLKVDVLGSTENDDDIIEKMYYQPAIDRARPTMLECRLNLPPQSVVTLSVDFEKVFLKYTEHRPDANRGFDVGSAVLTAWLPNKLTNQTSSSYYSNDNDSDYSSTSANTSASNSMSSSSMRIYTDTLLVSLPTPDFSMPYNVITLTCTVIALFFGSLFNLLIRSFYMVDSEDNKPKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LHF6</accession>
    <name>A0A167LHF6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Senescence domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_187923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288507.1">
        <property type="nucleotide sequence ID" value="XM_018439438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LHF6"/>
    <dbReference type="STRING" id="763407.A0A167LHF6"/>
    <dbReference type="GeneID" id="29000344"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_187923"/>
    <dbReference type="InParanoid" id="A0A167LHF6"/>
    <dbReference type="OrthoDB" id="20821at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009686">
        <property type="entry name" value="Senescence/spartin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045036">
        <property type="entry name" value="Spartin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068:SF43">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06911">
        <property type="entry name" value="Senescence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Senescence" evidence="2">
        <location>
            <begin position="206"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD70467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="465" mass="50636" checksum="D43A26C38CE7F0BE" modified="2016-07-06" version="1">MNPETQVNLSQDNLSYLCSVNGVSIQVFEQGKLSLFTEGQIVAYITSQPLPQQAIILQVWDNYSHQTATIVLLSNTRAWLQEDRILVFPREQGGGLWRLDCRQSDPTAFAALQDVLTYFIKYENRHNMRNTLAMMSPVSCQVTQVVANDIHLDANDQNAGTLEDPVAAEEAKIGQKLPVTVDRFDIQGDHDPAKIQKVKLLHQSSSAIVTGSGWLASALVFAGNTLAKGIQSGSEMIEKRVEPSQNPVRLSEGERQVLDSIADTTNLVCKTGVSLMDKAVSATVNGISNLCESTEQQQRSRDPVAQAGRSFGISALRAAATVLGGVATAASAVIGSSRDGIVHIVHRKYGEDAGYVAQRTMGSAADIADTLVYFDAGGIARRVLTSSAHAISAYHANRNGPTTQREIVFEVDHDEDQHQDEKGKGSYHQYQHQEEHQDYNNHQNSFSEACVSSSSSAKPIRSVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LU43</accession>
    <name>A0A167LU43_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptide chain release factor N(5)-glutamine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.297</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_66597</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="1"/>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289146.1">
        <property type="nucleotide sequence ID" value="XM_018441663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LU43"/>
    <dbReference type="FunCoup" id="A0A167LU43">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167LU43"/>
    <dbReference type="GeneID" id="29002569"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_66597"/>
    <dbReference type="InParanoid" id="A0A167LU43"/>
    <dbReference type="OrthoDB" id="269872at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:peptide chain release factor N(5)-glutamine methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050320">
        <property type="entry name" value="N5-glutamine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895">
        <property type="entry name" value="HEMK METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895:SF74">
        <property type="entry name" value="MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase small" evidence="6">
        <location>
            <begin position="124"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD71106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="309" mass="35056" checksum="C2510A39343CEE62" modified="2016-07-06" version="1">MPRWTVQQTQWIRQLLPVCDHDAHLAQRQLAWLKEKVLADHRGSSALESRLISHLSVAECNQLDEHVKERANNKPLQYILGTQPFCDLEIVTRPPVLIPRQCKITSKNILKPHAAARYSKENPLRVLDVCTGSGCIALAMSAHLPAARASILGLDIGSEAIDLARHNLKVLDDELQNPVEFRQQDIFDPVKEPFFDVVVSNPPYITTEEYAVLDADVKDWEDERALVALEDGTRVHKRIIEVVSAHTKPNDSNNDKNKNIEEREFPRLIMEMGGSHQVDALSYSLEKHGFRNISVWKDLADKDRVIVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LUZ1</accession>
    <name>A0A167LUZ1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_125983</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Endoplasmic reticulum membrane</location>
            <topology evidence="2 10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the OST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289187.1">
        <property type="nucleotide sequence ID" value="XM_018429068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LUZ1"/>
    <dbReference type="FunCoup" id="A0A167LUZ1">
        <property type="interactions" value="807"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167LUZ1"/>
    <dbReference type="GeneID" id="28989974"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_125983"/>
    <dbReference type="InParanoid" id="A0A167LUZ1"/>
    <dbReference type="OrthoDB" id="310030at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007676">
        <property type="entry name" value="Ribophorin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049">
        <property type="entry name" value="RIBOPHORIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04597">
        <property type="entry name" value="Ribophorin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007749222" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1" evidence="10">
        <location>
            <begin position="25"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD71147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="486" mass="55406" checksum="21CA79EBF9E76D86" modified="2016-07-06" version="1">MQSASLRIWLGALLVLCCAFITSATSPTNSISKTTIPIPTHFQNIKVLRIIDLRTPIVHEDIGFRAKNIGNQPVNEYYLTFKAQDEENIASINAFLRQGPKTALSIEQAGFDSEKELQLYKVTFDSPLQPDEEIRFGVKVAYTNVIEPLPKKLPQISRQHLIFNGNVYLFSPYNTEEIKTTLQLPNEKILSYTGNDEIVVKTGNKIIYGPFQNIPAESYNILSCHYEYLKPVLTLTSLRRDFQLSHWGGNLAVEEHFALRHDGAKMEEPFNRAKYQLSRSVHAQTNVLQHLPLELPAHARDIYYRDDIGNVSTSALTYGPSATILDIKPRYPLYGGWNYTWFHGYNIDLGYFARYSKKSGVYILNFKFVENVIDMAVEKVEVNVILPEGAKNVKVNAPFKLDSIEHTKHFTNFDTTGHYKVVLKKFNVINEHSQPIQITYEYSSIRYLQKPLAASVGFFALFIFSIIISKLPVVIGQQKKSLLKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LV40</accession>
    <name>A0A167LV40_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B22 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">Ndufb9</name>
        <name evidence="18" type="ORF">PHYBLDRAFT_31750</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289197.1">
        <property type="nucleotide sequence ID" value="XM_018439981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LV40"/>
    <dbReference type="STRING" id="763407.A0A167LV40"/>
    <dbReference type="GeneID" id="29000887"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_31750"/>
    <dbReference type="InParanoid" id="A0A167LV40"/>
    <dbReference type="OrthoDB" id="13598at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20263">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045292">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="17">
        <location>
            <begin position="18"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAD71157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="111" mass="12960" checksum="324C994BD03738EA" modified="2016-07-06" version="1">MSTSAASTAFKNAHRLHVQSLYKRSLKLSLDWYIQRDLWRQKALDIRAQFERNKHITSPKELQAIIAKTEQELKDWAHPDPYKLPMGPEGTKWERNLPPLMDFPTPSGSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LX64</accession>
    <name>A0A167LX64_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_114570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289314.1">
        <property type="nucleotide sequence ID" value="XM_018428400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LX64"/>
    <dbReference type="STRING" id="763407.A0A167LX64"/>
    <dbReference type="GeneID" id="28989306"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_114570"/>
    <dbReference type="InParanoid" id="A0A167LX64"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="53"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD71274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="285" mass="32867" checksum="55719A2BF4A5600B" modified="2016-07-06" version="1" fragment="single">MPHELQRTVQRQQQQQAEQQQRQLQEQPWWQYYYQLYHYHPPLGRKPTVFGPYLLLQTLGEGEFGKVKLAIHIETGHEVAIKLIKKDNIDSSTRMTKVEREISVLKTVRHPYIVKLYDVIETEKYIGIILQCASGGELFEYILAHRYLKEKDASRLFAQLISGVHYMHQKHIVHRDLKLENLLLDRHRSIIITDFGFANQFSSSRDALMSTSCGSPCYAAPELVISEGLYVGSAVDIWSCGVILYAMLCGYLPFDDDPANPDGDNINLLYKYILNTPLAFPDYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MRV7</accession>
    <name>A0A167MRV7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_186898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291764.1">
        <property type="nucleotide sequence ID" value="XM_018439297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MRV7"/>
    <dbReference type="STRING" id="763407.A0A167MRV7"/>
    <dbReference type="GeneID" id="29000203"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_186898"/>
    <dbReference type="InParanoid" id="A0A167MRV7"/>
    <dbReference type="OrthoDB" id="5689at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050769">
        <property type="entry name" value="NAT_camello-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947">
        <property type="entry name" value="GNAT FAMILY N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947:SF37">
        <property type="entry name" value="LD18367P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="43"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD73724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="185" mass="20444" checksum="A14E0322050D576A" modified="2016-07-06" version="1">MSPIPVRSIYVRLTTIADLKHNEKAHSVINAAYRSTGGWTTEVDLVGGERETIEGLAQSVRDQGKPNTLMYAFETNENGTEQVVGTVQIQPIVKAPGEAEIGLFSVDPKYQSKGIGGKLVRAALDTMKTMGFNVAVMKVIENRADLLQWYYKLGFVNTGERVPFVFPDLLKVKDLSFITLKKPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MSK9</accession>
    <name>A0A167MSK9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_186934</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291844.1">
        <property type="nucleotide sequence ID" value="XM_018439301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MSK9"/>
    <dbReference type="STRING" id="763407.A0A167MSK9"/>
    <dbReference type="GeneID" id="29000207"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_186934"/>
    <dbReference type="InParanoid" id="A0A167MSK9"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46225">
        <property type="entry name" value="C3H4 TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46225:SF19">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="480"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD73804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="534" mass="60118" checksum="2287B3EC5DA0A2CD" modified="2016-07-06" version="1">MSDVNNNSMGPVLPADDEARAVFHEIKEVVVDKLHELNHEDNVHGLHEMDQLKRISSFKLVEYAVEEVAYGFNYFGKIDLGDEKFIHVRAHKYHDGRVEFYSILTTPETAIWTREEPLVLSHRYQPSTSTHSSGSSASSTRPALPQILTHSPSNAVHLSRSTARTSRRVRSHWVTHFTHSWRRSSRTSKLYLASSLTLVALQVIACAGVLAFSWNMYCDRPVRIFLTVHLLRLSLSSPITIYLHFDPRQTPQCPSQMERGEAYPMAEQGSSTGQVPNVQIPPEILPENGLGSWVDRIKGSLDFFAVLWFVVGNYMIFSSTTCVETATPLYYLALAVIIYGYIILAVPIILCTSVIFCLPCVLGFCINTIPVGMRLLHVSDGVKMGGSSVEEISTIPIYRFKSSKKPTVVRPPKLPGLLPVQTMTIDPVLGERNSIQVKSPPGWLDKLWLYIGLVEEPLSKDSPEQVYDVLEIPDEKDQVCAICLSMYEDGDILCKLWCTHHFHKACVYEWLALNYRCPMCKQDSRGKKSSTVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MUF6</accession>
    <name>A0A167MUF6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_64966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD74019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292059.1">
        <property type="nucleotide sequence ID" value="XM_018441379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MUF6"/>
    <dbReference type="FunCoup" id="A0A167MUF6">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167MUF6"/>
    <dbReference type="GeneID" id="29002285"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64966"/>
    <dbReference type="InParanoid" id="A0A167MUF6"/>
    <dbReference type="OrthoDB" id="5549748at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018859">
        <property type="entry name" value="BAR_dom-cont"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10455">
        <property type="entry name" value="BAR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="48945" checksum="8AF9FA91EBF11DE3" modified="2016-07-06" version="1">MSEHTQPIQPTQFDQFDQPTQSTQSTQPTQFDQFTQPTHTVQPVHTVQPVQPVQPVQPAHTVQLVQPVEPTHTVQHDQKNTVKMVEDDHQVQAGSHSQSLNPNVIINSALDGFAELSSKINPFAQKIGKSLGQAKQYAQEKLGTADDVTELPQEYKDLENRVDILRNVQANLVKITRTYGNPSHDYPVQLQESLLGLTSSVTREIQNMTLSTTERSNATTTPPATAAAAAADTATATATATATATATATDNSSSNSSSHSTHSAGSIADQKLHPKTLSHALARVAGQGAEQVGLEDHYGTALFKVATITEKVGNAQLAMDDAITTKFTQPMQANLATVIEQALKARRNVQSSRLALDTVKARYKATTRLDKEEAIRLEVEEAENQFVAMVEEATSLMKAALDNPEPYRNLTDLVAAQDAYHKEAHELLSELTPELDALRVAQESHFHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MV49</accession>
    <name>A0A167MV49_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_63935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292154.1">
        <property type="nucleotide sequence ID" value="XM_018441205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MV49"/>
    <dbReference type="STRING" id="763407.A0A167MV49"/>
    <dbReference type="GeneID" id="29002111"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63935"/>
    <dbReference type="InParanoid" id="A0A167MV49"/>
    <dbReference type="OrthoDB" id="2250876at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="219" mass="24982" checksum="167B605CE169947F" modified="2016-07-06" version="1">MAVSNYKGHFVYNEEGIFSDEEFEVNHNVILPKLHIPVPNISAKDLTIINKRDYNNAFLNACQAADWDNRGNKRLLTIMDTYNLRPIALINDDVEYNPLTHEKNLHAFKKDRMKVYPLVPKQSPFEEAKTVQTAPISLYSAISTGSPYLRQHIMNYTYIELTNDMPMFLNQDYSIHKSVRYACSRALAGSILLNESTGKALLVNCVEVFGRGRTLGAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N2S2</accession>
    <name>A0A167N2S2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_144190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292870.1">
        <property type="nucleotide sequence ID" value="XM_018431164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N2S2"/>
    <dbReference type="GeneID" id="28992070"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144190"/>
    <dbReference type="InParanoid" id="A0A167N2S2"/>
    <dbReference type="OrthoDB" id="2442555at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="326" mass="37256" checksum="686E26385B762B7B" modified="2016-07-06" version="1">MNMIFDATTMDIVDDYEERTTYTMANAVLHEWEVTYPNSGNGIQTLVTKMDFEQTTTNEETCIQGSDVETLEEENEKTEKKPYKPRGTYCKYMPEQVQGLFELVIENRWTAKMATEKMGINVRTGQNYIAQYRKDEEQCLPGSTGKRIVGAPHKLLQQHSFFLIAYFENNVAATLQEVRTALLEEFQDLMITLSGLQKHLVNKCCLTLKKLEKLPAARNSEWVIQLRKNKVTEWLSIPDFDYVRDCVFIDEAGFNMHIKRNFRRSTRGKPAKTTAPTQQSVSITILGAISQIGVISVTLRKPQAVVSSKKRKLDKKVEKINGHVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N801</accession>
    <name>A0A167N801_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_143536</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293319.1">
        <property type="nucleotide sequence ID" value="XM_018431004.1"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167N801"/>
    <dbReference type="GeneID" id="28991910"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143536"/>
    <dbReference type="InParanoid" id="A0A167N801"/>
    <dbReference type="OrthoDB" id="10070851at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF160">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN EFFECTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="298"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="10">
        <location>
            <begin position="937"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="431"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="852"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="890"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1135"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="445"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="859"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="908"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1135"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1158"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1183"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1200"/>
            <end position="1213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD75279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1434" mass="162172" checksum="29B14A21A6EE2957" modified="2016-07-06" version="1">MISQHTNQPTLLTLHDAITDSPVYRTNVHHYDEQLDHLEKWLDSLSRHLKLYTEKINKLNLETDIVCQRVVPVGIESALIDPDVTMPILKTFANALKAGLSFKSKLVSDLEENLVQPLQQFMKTHLKDFKAFRKQHEKALEQYEIQLSRHATQGKNKEPSALREEAFRLYEARKAYIHMSGEHVVRIIKFRSLLEHCLVERFSAATTAHKEFDVDRQMWDNLDTILVSWRQWLVDDKRTCIYQLKKHELAREKLEMEYLSEIEPFRQLEYYGDSEVTLATQEKHATQAPPSLSDDHQSSSKWGYLFVRSSTHSTWTRKWFFLHNGYIGFCSTSIKNKEGNTVTLDERIPVLMCTIQPLKDADRRFCFEISCQKYGSIKTSTHTGLHIIMANTVFFSLKKRITYIAQAERKQDVQSWIDAFETSRSVLIRRNSIPPRRASSDGSHRSITSQSDSDSMPSRSPGVVSAKSRSTTEVTTPIDIPAILSTTPTSPLSSIPGFTHIQGIQSISPFNSILKSPKKMSLDKIGTSNVSLVMLSTSFEFEYISLSESISLTPLLVWGAASSQIRMTNSLTNQLFPLWGIPWTIAFMTVQFLSNTDTSSAPSSKLLTEKEVIWPIRPKDVVETRKVNIVDYAPQLEVHNQGLRSLFSGVAESEVVLDVFVCSLRKKPTESDFKSPTSPTSPVVNSLLSQITTAYQSSSSELGFAYTGRAFVTQETFWFYSTILMTCIHTVAVRLQDIKEVRVVKDLVLSSEEDNQNGFSCCALVIELVDETKGPVTFSSIVSDIDSIANKLRFMVSNAKAKSTDLNKLYQEIQRISETNSGKVFQENMVSSDRSTYNIFGAETTSLPAPIAASESKSRTGNIRNGINSLRSKQSEALGTTLSLTKKVLKRDRSTKAPNTLTVETKKPIPPPVDPDALPPSIKTPTSPCSCECSDHLDRLESECEFPISAKRLFELMFSDKYNGAPTDGGVWKAKNESVDGHDLRVTNWGQEDDKTTRTLKYIMPVTNPIVRLKEAEVVENQVIIKQDPYLCYVVQISTKTAALPYADAFIPSVRYCITWVGPSKCKLACYMGVAWVKSVMLRSVITRAALKAMGESVCLFVDILREEADKVAERVDEERRVIFSGNVDCAPVEDVDEADDSQGLEESVENEDRKDFSNFSYTSGISKTDFHTNYTDDEENEDPPRQSTENRRIDDHQTHSNMVTSSGCTSSPALPPPRNSILVSRSTVEKPKTKSSVKLRRKAKKDEFTAGWGSKVPLLSMVALVSGALLLWIWLSRIRANVQPEVIEVGTNNSMKTNNRSIRVISKAVYLKDLETGVLENHMLPPYSKAESFQKFLKQKRTDDISTVQHQWFSGKNYKMAIELDSSRERIAVMRHDVLTIFRMLNKVDTQLLENEYMNWLMDNRQKCKKQSSNAYDLVQCDHIDAQLLEFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NJH7</accession>
    <name>A0A167NJH7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_110069</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294110.1">
        <property type="nucleotide sequence ID" value="XM_018428150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NJH7"/>
    <dbReference type="FunCoup" id="A0A167NJH7">
        <property type="interactions" value="341"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167NJH7"/>
    <dbReference type="GeneID" id="28989056"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_110069"/>
    <dbReference type="InParanoid" id="A0A167NJH7"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="13"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD76070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="347" mass="37994" checksum="011FF9575458C906" modified="2016-07-06" version="1">MSTDNFHGWACHGKDKPLELSELPLKAFDDYAVDMDITHCGICGSDIHTIDSGWGPTDYPCVVGHEITGICTRVGKKVQKVKVGDRIGVGAQSGSCLKCEDCKSGNENVCMKGIVYTYSSYWENGDKSYGGYADKWRGHEHFIFKIPDNMSNEIAATFFCAGVTTYSPLKHYNVKPGDKVGVIGIGGLGHFGVQWAKAMGATVVALSHSDRKRDDAKELGCDDYIVTSNKEIMSAHNGTFTHILCTNFSPDFDWESYLSLLKANTHFIVVGVPDAPLSGIPALLLASRQIAIVGSAIGSPSMIEDMLNFAATHNVKPWVNKYPMKEVNEAIKAMREGKPRYRIVLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NML8</accession>
    <name>A0A167NML8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chromosome segregation in meiosis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_166260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an important role in the control of DNA replication and the maintenance of replication fork stability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CSM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294329.1">
        <property type="nucleotide sequence ID" value="XM_018435387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NML8"/>
    <dbReference type="STRING" id="763407.A0A167NML8"/>
    <dbReference type="GeneID" id="28996293"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166260"/>
    <dbReference type="InParanoid" id="A0A167NML8"/>
    <dbReference type="OrthoDB" id="437078at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012923">
        <property type="entry name" value="Csm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040038">
        <property type="entry name" value="TIPIN/Csm3/Swi3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220">
        <property type="entry name" value="TIMELESS INTERACTING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220:SF11">
        <property type="entry name" value="TIMELESS-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07962">
        <property type="entry name" value="Swi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation in meiosis protein 3" evidence="8">
        <location>
            <begin position="66"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="20"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="152"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="266"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="185"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD76289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="328" mass="36338" checksum="6BE68ED71ECBE258" modified="2016-07-06" version="1">MNDDLNDSFYDLLGDLDPFGNSTSNDTSQNTPSNFDPLAGRGNKRSSGDGDEDEEAPIRAKRQYKKLDADLMLSDKGLPRIRHEAPWLHFKGRGYEDLDLARLMEFYHIWADNLFPRLPFSDFSHAVLKATANGRCQTALATWQDEFEAKRNAVQHKDDGPTDIGELSGMTVEDEENERQTLSSTTTTTTATAAATAPRNLSSPQRETSTASSSSSSLQPVNTSTSSRSHIINAFVTTSIDQDDSSDDEEPLFQFPKASPNIIAAAVSKKKQETPRVPNPAKANRAAALAKLAARKREQEKQRMESMRNNDSEDEDEEDPGAEYINDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NVH1</accession>
    <name>A0A167NVH1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Lysosomal dipeptide transporter MFSD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Major facilitator superfamily domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PHYBLDRAFT_165215</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79415"/>
            <dbReference type="ChEBI" id="CHEBI:192470"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:79367"/>
            <dbReference type="ChEBI" id="CHEBI:229968"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)</text>
            <dbReference type="Rhea" id="RHEA:79375"/>
            <dbReference type="ChEBI" id="CHEBI:229967"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79383"/>
            <dbReference type="ChEBI" id="CHEBI:229966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79371"/>
            <dbReference type="ChEBI" id="CHEBI:84315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arginyl-glycine(out) = L-arginyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79391"/>
            <dbReference type="ChEBI" id="CHEBI:229955"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79411"/>
            <dbReference type="ChEBI" id="CHEBI:229953"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79379"/>
            <dbReference type="ChEBI" id="CHEBI:229964"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-histidyl-glycine(out) = L-histidyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79395"/>
            <dbReference type="ChEBI" id="CHEBI:229957"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)</text>
            <dbReference type="Rhea" id="RHEA:79399"/>
            <dbReference type="ChEBI" id="CHEBI:229954"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79387"/>
            <dbReference type="ChEBI" id="CHEBI:229965"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79403"/>
            <dbReference type="ChEBI" id="CHEBI:229956"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-glycine(out) = L-lysyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79407"/>
            <dbReference type="ChEBI" id="CHEBI:191202"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294736.1">
        <property type="nucleotide sequence ID" value="XM_018435181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NVH1"/>
    <dbReference type="STRING" id="763407.A0A167NVH1"/>
    <dbReference type="GeneID" id="28996087"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165215"/>
    <dbReference type="InParanoid" id="A0A167NVH1"/>
    <dbReference type="OrthoDB" id="424834at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052187">
        <property type="entry name" value="MFSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="471"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="508"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="587"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="20">
        <location>
            <begin position="105"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OAD76696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="619" mass="69403" checksum="23574366210F8D03" modified="2016-07-06" version="1">MARIDTFLVLELLPKDLQNIRIVQHFLFSLGSNVNDADLPLRRISSFFGICSRNYYQDLPFTTESVHEDLFPSDQSNSSGLPNQDSIYVDKSQDLLKEATWQTKLLILVCMLSLPVGCHYLEATMGTLKTTLKNSMHINNTQFSILLSSVSLVNTILPLLAGTFVDDLSSVGSIRGSTLVSTVIFSGSLMVSLAAERNSYPVMITGQIIYGLGGGMIVTMQEAILSRWFRDRQLAIVIGILLSFARLTKWAAKMVCYPIVNSTQSHAWPIHVATILCGVGIVMNFLYWAVMYRHGCSTVYGKEISQPITGYQSQFAASQSPNNGRSSFRWSSRMFLLLPSTFWMVPWVQLVMSSVLSSFDDVATEFIQFRYNTTSVMAGYQSSLTQVMPIVVAPIMGIIVHRYGKRLTSLFFATLILILSMVLLAYTWVTPAVGMILFSLALALGPVSVLSSTSLLLPHELAGTGMGLHKCANNIGSTIVSVLIGYVQDLTFHDGDPHDDQQDLESEYDGVMIFFLIMGCFSTLIAILFWVMDSRLLSGWLQADIKERERRIEQVKLEQTESKYENKNLFDTKSLQKIGSQMRTKPTYVYVSFYGFWLVVSWVIFFAFALMPVYQKYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NXX4</accession>
    <name>A0A167NXX4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_165351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294891.1">
        <property type="nucleotide sequence ID" value="XM_018435211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NXX4"/>
    <dbReference type="GeneID" id="28996117"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165351"/>
    <dbReference type="InParanoid" id="A0A167NXX4"/>
    <dbReference type="OrthoDB" id="3247418at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="679" mass="77251" checksum="724440AA1A618359" modified="2016-07-06" version="1">MSTIPELYNEKCHCAGCSQNDPGYSFVARRTAQHHNKRARLNAIRCERDMSTQRNMMDVDDEPILTHQPGALEELYTQTNSPVWEGASMSDTEDVSVTNDAISNGNNNDSGSNSNEISEDESEDNVIELDNNELNSEDPFATPNMPQNPVHRFIATFVVMFASHYVVDKGAVVLIEFINKLLTIYEQDFQLPLSLPGLQHMTGFSAMTKGIKIFVVHQDCHKVYEQSASVPSHCDFVKLGACSSCNCQLMKTSALGALVAKHSYLYQSVLHRLGYLDLVRGTIIDPMHNLFLGTPKRLMDRWIKDEDIQDGDFAAMQKTAETIIVPGGYTSLNSKIGKQLSYMKADVWKSWVLVYSPVLLKDVLAKDRFKNRINFVDACCLLIKPTITFDEVNTAHQFLQTFCTRCDELYNAKILTCNMHLHLHLRDTIRDFGPVYGYWLFGFERFNRLLKNLKTNRKIGFEETFMKKFIKDVHKDDLVNSFLQSTRQTSAFPLLTKLTSSFTPTTIPSIRQRTFHIQSFVEASEDPNVLVKGNEPLPPSAFPLSLKSATTMSDIHYVHLLQYYKAVYNNEQLVHFQQASESPYFVDNTITLLKYINILGQVYKGKGESGSRGSLVQAKFIRSTEYEHIETCFPTFSSDDFQCVLPVHRIMLEVATAEHTTHRKVKKMLVIPLPKKQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P564</accession>
    <name>A0A167P564_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_76317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295308.1">
        <property type="nucleotide sequence ID" value="XM_018443141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P564"/>
    <dbReference type="FunCoup" id="A0A167P564">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167P564"/>
    <dbReference type="GeneID" id="29004047"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_76317"/>
    <dbReference type="InParanoid" id="A0A167P564"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="98"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD77268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="349" mass="39562" checksum="C7ADD48C9F1C8CBE" modified="2016-07-06" version="1">MGSGLSRSSQTSSVRRSHRNKPARDIYPEKRTSTAQGQRIVEGRIYHSEQDSNYPLPMDDREIDRLHEEHFLTKELLGCNIMREATKRLDFQGGELHILDVCCGPATWLCQTSLEYPNCHFSGVDMSTMWPQIIRPVNLSFTRANVLHGLPYPDQYFDFVQLRFVALAFKSDEWTRVILEIKRVLKDGGMFQCIDLDMTISKGGSDIYSATSEETKVHPEDEFSRKKDTVASLLHDIKTEVSKFDKFCVLKGLDKASGAKIDMMLSDARMTILQSEYREIPLGWGGLIGDAYYNVYEATLEGIAPLMRQSFDNPSSPEPSAVCAPKKDMMNTKSFIGLYAFLAQKPLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P627</accession>
    <name>A0A167P627_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_141204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295358.1">
        <property type="nucleotide sequence ID" value="XM_018430548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P627"/>
    <dbReference type="GeneID" id="28991454"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141204"/>
    <dbReference type="InParanoid" id="A0A167P627"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="157" mass="17838" checksum="9DE43E0BAA717320" modified="2016-07-06" version="1">MKLFTGIREFVKTTRLVGSCLTQRQELKTSSSLVHNPEHSKDYTGSKLWSFFISNNKVQNRIHFDFFSSTVNAAKVDPSPSGRRPDLTAKGKKEFVALSPGKSGMENRGKFKQRCTLAYTFRANGCFLDQRFPHRIAHNHNQLVWTLAQEAASEICQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PBU7</accession>
    <name>A0A167PBU7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein/NADH dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_141492</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295657.1">
        <property type="nucleotide sequence ID" value="XM_018430600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PBU7"/>
    <dbReference type="GeneID" id="28991506"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141492"/>
    <dbReference type="InParanoid" id="A0A167PBU7"/>
    <dbReference type="OrthoDB" id="1696305at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040049">
        <property type="entry name" value="Ribosomal_mS25/mL61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="6">
        <location>
            <begin position="84"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD77617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="149" mass="16380" checksum="6F73A20DAF48D301" modified="2016-07-06" version="1">MRQEISLPSPDRKSNSDVAGSQTDSSFTKLQSNHSTLLQQSLQSQPTTTTLVVVPELGAQKLAFNVSKVSLTIPIKGKHEGMGAKHFLHESLPRLQYNNPSVVFEVAKNVDPKTKPELTIHFNEQSPKILAIPSLHSDVICDMLLRATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PL35</accession>
    <name>A0A167PL35_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_71798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296194.1">
        <property type="nucleotide sequence ID" value="XM_018442540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PL35"/>
    <dbReference type="STRING" id="763407.A0A167PL35"/>
    <dbReference type="GeneID" id="29003446"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71798"/>
    <dbReference type="InParanoid" id="A0A167PL35"/>
    <dbReference type="OrthoDB" id="2379842at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22744">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="673" mass="76839" checksum="B0C0BF51CE78DD9A" modified="2016-07-06" version="1">MIHSKSKKEFDWALNKFNAVSAGSEVENGNVKAPVSAYFHDRWITCQEKWADYLTQKIMHFGCTTSQRVKSAHQALKRGISAIASLDLAFENISRYIERLERDFRNVEIRESTTVDPLVGRNKLLSRLLMKVSKRALLVIDQEVRLKCESSIVCEFMNKLQYGLPCRHSLPAGRDIYISDIPERWVIDPRNVKPRDNTCQGNFQLEERPEVWMEEVIKLEALFWSCESSQQVANLLNKINKVTSEFEGKTGHPLINFQAPKKIKYPGRRKGGAHPKYLPKDFGQANWRKISVSSGHAGLKAMVRLRAKMREGKPAATQKTKNKKQNKNKQEPLDPVDATKNKIKQIKQEPLDPGCRLTRICFLVDATKNKTTKIKQEPLDPVDALQKNGFKRPATTLEDYQYDNCISVGKRVKFQPSFPVSHEIVNDVKGGFSPTADGWCGFRVLSHLIYKDQNKFSLVKRDMLAALPKYKTLYTNTFGTDTSQLGKIIQYVSQLDYSNTNTNTNFIPVCSDASMWFNTPDCAQLAADTYIRPVCVYSDNPNTPSTTFLPFALPNNKTKQQQPLIFNYVNSNHWTTVDLSPRQSFLNLYKSYQFVSLCQHKLSITCGLNDSLLCFFLEIIRGKYFTLRVTLITSELKIINIGWCYTDRAKLSSNMLYYAFASSYFINSSLGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PPI9</accession>
    <name>A0A167PPI9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_163423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296347.1">
        <property type="nucleotide sequence ID" value="XM_018434797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PPI9"/>
    <dbReference type="GeneID" id="28995703"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_163423"/>
    <dbReference type="InParanoid" id="A0A167PPI9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="134" mass="15511" checksum="B5D89F006C3A81C2" modified="2016-07-06" version="1">MRQSKHQCGPQERLMLQMRTREKKGFSETLKVTVKIQSQIKIDKAHFYQSPKSGLYLQVSRPSRFPRRGPMQSSKSKFQKKNQKPKTKSEAYTKSCKKNRHILSPPLQKDQKKSELEAYTKSSTPKGSNPKTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PQ51</accession>
    <name>A0A167PQ51_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="14">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHYBLDRAFT_107982</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="14"/>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296378.1">
        <property type="nucleotide sequence ID" value="XM_018428025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PQ51"/>
    <dbReference type="FunCoup" id="A0A167PQ51">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167PQ51"/>
    <dbReference type="GeneID" id="28988931"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_107982"/>
    <dbReference type="InParanoid" id="A0A167PQ51"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF148">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="4 16" id="KW-0349">Heme</keyword>
    <keyword evidence="9 16" id="KW-0408">Iron</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="17">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="18">
        <location>
            <begin position="94"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAD78338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="486" mass="54340" checksum="793BA70679F18CDD" modified="2016-07-06" version="1">MYIYVDDLWVILHGKVYDLTYFLPEHPGGQKIILKYAGKDATSAFEPIHPIDIITRLLPAEVCMGSIDPAALKGATKEESEEDKLIRIAREKMPRLEEMYNSFDFESVAKRVMKPDAWAYYSSGADDEISMRENHNAFHRIWLRPRVMVDVKHVDMSTTMLGCPASFPLYITATALGKLGHPEGEKVLTRAAGKTGIIQMIPTLASCSFDEMVDARLDKQNQWLQLYVNEDRNITKHLVQHAEARGIKGLFITADAPQLGRREKDMRQKYANEAPDEITRSEMSMTRNEGAARAISTFIDPALNWSDIPWFQSITKMPILIKGVQCAEDAVLAAKYGCQGVVLSNHGGRQLDFAPSSIEILAEVMETLKREGLDKNFEVYIDGGIRRGSDIFKAIALGAKGVGIGRPALFAMSSYGDAGVERLISLFQNELEMCMRLMGTPTIKDIKPEMVDIRNIKDHFVANPTDYLAAGAYERMQPRGGIISKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PTR8</accession>
    <name>A0A167PTR8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_62710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296564.1">
        <property type="nucleotide sequence ID" value="XM_018441004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PTR8"/>
    <dbReference type="STRING" id="763407.A0A167PTR8"/>
    <dbReference type="GeneID" id="29001910"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_62710"/>
    <dbReference type="InParanoid" id="A0A167PTR8"/>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="440" mass="48810" checksum="5CDF193F90AE1414" modified="2016-07-06" version="1">MDCLEIKDPIKPRVISWVPCPVQKLESPLDTYRRLSYLQLTSDPLPQSTKSAPFEIDLQCLHVSSETCAKAKKAFDQAGSLISSAIFFREPVRVNATFLSFCESGGECGSSPARLIPLLNEDGMVRLHPQSLVKQLDMPISPEYSHSDILSVFNADAPFWFEHEFMHGLGFYSNWSKHIPSIDALVPDPSLLLADETLVIIDPQNNAVIETKFLENVLDKYMVILNPESEYNLFPTSDLTRQFNKIEVNSTEGLIGSPEFGPAFDMSRLSVLPGTLGIGLVGPQGVYDDFVILETSLVPFQRGSSISHVDYNSYTDTPDFLMRYMQDRGVTMTDMVLKGGGDSPLGPKLLRIMEQIGYTIIKTNETESSAAGDFRRMVNSLQHNAHATQSSTTAKPYLHSTPHSHSSTGSRFAEPTFLMVIIGSLCLGILLYLEKPFSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PZM1</accession>
    <name>A0A167PZM1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_163919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296866.1">
        <property type="nucleotide sequence ID" value="XM_018434892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PZM1"/>
    <dbReference type="GeneID" id="28995798"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_163919"/>
    <dbReference type="InParanoid" id="A0A167PZM1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="144" mass="17390" checksum="5399BAE0B55DF31E" modified="2016-07-06" version="1">MSYELFQIYQMIYLSDISGIQFAVFYYRLTIEASQKKCSRLYHIRTMYTYLIQTNSYNVEIFENTIASYFIYIKRANFRCNIFLNSVYNDGYKCRVLFARRTTTDPFDFFKRMENDFNVEKVTEWILGKEMPSTPIIVMVAQYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q216</accession>
    <name>A0A167Q216_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CCHC-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_164023</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296967.1">
        <property type="nucleotide sequence ID" value="XM_018434921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q216"/>
    <dbReference type="GeneID" id="28995827"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164023"/>
    <dbReference type="InParanoid" id="A0A167Q216"/>
    <dbReference type="OrthoDB" id="2202398at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD78927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="439" mass="47929" checksum="53A8DB5E310E2AFC" modified="2016-07-06" version="1">MALPAKTPPPLPRDPSPPPGSPTPSLNTPSTPTGSPPLSPSYVAAAVKSVDNSCTSRIIGSIAGNGAPRIWKEGSSPFSVFYEVPAEGNPLRPLFFEALNTAFPLGVGRGLTYASRTSRTSFEFHLVDQEACSRACQVGFPFNGRTVFASPAIPSTFKLLRLRVSRLPLHGYADFDELAENLRRCLAIYGQVQEISLNLKYNYPDGTGTIHMLRPPNPDLHLRHLEHEIKYNETTTFLATWARMGTHCTFCKEMGHEKEACTKRPKETRTCFRCGKVGHLAHQCPRNEEAESKRPRKTARSPTHAPAPPAAQMYHGLLPSETIYGSQHAPQNIPLPPLATESLSKPRAAPGAIPGFLPANHPDFLIEAAASTGMDDNVQLVKTSDGELGNEETKKSDDEEYYSDDDIDEVAKYFAQMEDDPMDGENDGGQDPPNPALTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QC60</accession>
    <name>A0A167QC60_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_58504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297499.1">
        <property type="nucleotide sequence ID" value="XM_018440336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QC60"/>
    <dbReference type="STRING" id="763407.A0A167QC60"/>
    <dbReference type="GeneID" id="29001242"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_58504"/>
    <dbReference type="InParanoid" id="A0A167QC60"/>
    <dbReference type="OrthoDB" id="5865767at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001605">
        <property type="entry name" value="PH_dom-spectrin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00683">
        <property type="entry name" value="SPECTRINPH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="100"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD79459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="246" mass="28531" checksum="30FD2D01509A93FE" modified="2016-07-06" version="1">MPWQRKKSAQWPFVLNKLRFYSQSSHSSVSIPISVASEQVEPGAEAPSEQPKDDNIDLEPPHYDDPIHPWTSIFPAYLSQRTVEPREEEGREVLPEYECTIFKMGFVRVKREMERPKVESKDRAWKKLYLVLWGTTIHAYKIEPYEGMKPVWSYSMQLAEAGSAPDYLKYRNVFRLRVSNGPQMLIRSSLEEEQVLWIEHLQASANVSPDLDVRPMPRFITLTTRRRRGRAARTAGQSEPVEASLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QGN0</accession>
    <name>A0A167QGN0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_58716</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297708.1">
        <property type="nucleotide sequence ID" value="XM_018440375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QGN0"/>
    <dbReference type="STRING" id="763407.A0A167QGN0"/>
    <dbReference type="GeneID" id="29001281"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_58716"/>
    <dbReference type="InParanoid" id="A0A167QGN0"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="100"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD79668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="513" mass="56661" checksum="B7248C719805C14A" modified="2016-07-06" version="1">MTFLNHTLDNLSSPTLDSDNNVQTIDFRNDHLVSTSSASPLNSEQVRTYEPANTADYAQLEIDDSETTLLGSQQRLLDHDDTDEEGDPEELKSYRLPSEGGSIFSSFLNMANSIIGAGIIGLPFAFKEAGFWTGIGLLILLTVVVDWTVRLLMYNGKLAGRTTYQDLMEFSFGRPGLVAISIFQFAFAFGGMCAYCVILGDTIPHVIRSIFPNIHNVPLLWIFGNRKLCITFFTLFVSYPLSLYRDISKLAKTSALALVAIIVIIVSVAIEGPKMPATIRGSSDNMFIVINNEVFQAIAVISFAFVCHHNSFLIFGSLKQPSLNRFAAVTHWSMFIAFATCFILAVSGYLVFTDKTTGNILNNFPQDNLLINIARLAFGLNMFTTIPLEAFVCREVMETFFWASEPYNRVRHCAITTILVLISLIISLVTCNLGTVLELTGAFSATALAFILPPLCYLKLANGPVWQINKIPHWLCMIFGIIVMAVSTFYSLQKAFIGSSAGVHKSQSELVCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QJ59</accession>
    <name>A0A167QJ59_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_157335</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297818.1">
        <property type="nucleotide sequence ID" value="XM_018433601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QJ59"/>
    <dbReference type="STRING" id="763407.A0A167QJ59"/>
    <dbReference type="GeneID" id="28994507"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157335"/>
    <dbReference type="InParanoid" id="A0A167QJ59"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000340">
        <property type="entry name" value="zinc finger protein 473 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD79778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="109" mass="12422" checksum="599E772F24833010" modified="2016-07-06" version="1">MQNRPLQHIVSPYINDDYIIPKTEYCQDINSNGFTPLRGVSSKASSTPPRRYKCSLCIKRFTRPSSLATHMHSHTGEKPYKCSVDGCGRRFSVVSNLRRHAKIHFGNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QKC6</accession>
    <name>A0A167QKC6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_139848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297874.1">
        <property type="nucleotide sequence ID" value="XM_018430291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QKC6"/>
    <dbReference type="GeneID" id="28991197"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139848"/>
    <dbReference type="InParanoid" id="A0A167QKC6"/>
    <dbReference type="OrthoDB" id="10311737at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="148" mass="16519" checksum="C504A025476F4CAB" modified="2016-07-06" version="1">MSLSDLLNLAYGWLKPASNRSRLTGVVQLASYITACVLAVLSTVSLFCAFIALSMCDDLGRISAATRNRLWVTFKERMQQVDWTAVMTLITTHLSKITSEKNPWSALYALYPVFGSINIHTVQGFVLRIPSYFSHYFNISPGTKPSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QW35</accession>
    <name>A0A167QW35_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_61417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298407.1">
        <property type="nucleotide sequence ID" value="XM_018440802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QW35"/>
    <dbReference type="GeneID" id="29001708"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61417"/>
    <dbReference type="InParanoid" id="A0A167QW35"/>
    <dbReference type="OrthoDB" id="5597211at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058940">
        <property type="entry name" value="mS26_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26163">
        <property type="entry name" value="mS26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="249" mass="28258" checksum="B662A8D561D050CC" modified="2016-07-06" version="1">MQRFNRLIQSTTTATTKAHWTPFRLFTTEAESTRPGYAPGFAPPPNSRDTPKLSSKRRNLGTSLPSHLGNASQRTAAETTSPKKHHREELRTRRHQYAQELLEKHGRREAAAAAKRMLNQEKIEAVRAELIKEQEEQKALEDEVVSMLSLNATESLADTRTKRDATRVANRLQFEANQKESRLKLISKLYASTENFVTLDNLDERVDAVVKTKQQLPYAGSLHELLSAQSVDRAEIEKRKEMLKEAVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R6I0</accession>
    <name>A0A167R6I0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein phosphatase 1 regulatory subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_129474</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SDS22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299004.1">
        <property type="nucleotide sequence ID" value="XM_018429288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R6I0"/>
    <dbReference type="FunCoup" id="A0A167R6I0">
        <property type="interactions" value="287"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167R6I0"/>
    <dbReference type="GeneID" id="28990194"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_129474"/>
    <dbReference type="InParanoid" id="A0A167R6I0"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000055">
        <property type="entry name" value="Protein phosphatase 1 regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000446">
        <property type="entry name" value="Protein phosphatase 1 regulatory subunit SDS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD80964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="40124" checksum="4427A5BF998C2FCC" modified="2016-07-06" version="1">MSDSTENITETLTSNVNTSQNDTPIKPHKVAMIQEPSTDAEDSEDEPVTETTEEGLLDDYPDDTTEVDAIHMRVADIPSLGLERFQNLQRLCLRQNFIIDVKGLEGLKELKELDLYDNKISRISGVNSLQTLESLDLSFNKIKHIKHIENLVNLKDLYFVSNKISKIENLDTLVNVTNLELGANRIREIQNLDHLVNLEQLWLGKNKITKLENLGALRNLRVLSIQSNRLTKLTGLEGLVNLEELYTSHNAIEKIEGLENNHKLTILDVASNKLTHIENLSHLKNLEDFWANGNQFGNECFAELERELGNIKTLQTVYLEGNPMQLENMATYRNKVRLSLPNIQRIDATYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167REM4</accession>
    <name>A0A167REM4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_139020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299509.1">
        <property type="nucleotide sequence ID" value="XM_018430134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167REM4"/>
    <dbReference type="GeneID" id="28991040"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139020"/>
    <dbReference type="InParanoid" id="A0A167REM4"/>
    <dbReference type="OrthoDB" id="2251404at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="114" mass="13046" checksum="360CD42979854221" modified="2016-07-06" version="1">MTRPLNADWRFQMCLRFADSRLVADAHFEHFSVAHLPPSNFDLWVKKVTNDNALKVMIFSQVADFLIVSSVRLERYFGSELGPTTNNFQPTTSTKTYVAKESITHGQRILHCNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N3C5</accession>
    <name>A0A162N3C5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_173591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286138.1">
        <property type="nucleotide sequence ID" value="XM_018437062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N3C5"/>
    <dbReference type="STRING" id="763407.A0A162N3C5"/>
    <dbReference type="GeneID" id="28997968"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_173591"/>
    <dbReference type="InParanoid" id="A0A162N3C5"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF3">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="27"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD68098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="351" mass="37950" checksum="95CC31FC31818F89" modified="2016-07-06" version="1">MDLPLSTNFQASQPTTFRKLEAFAIGNDFSKVTRMVSVEYESLLKNLRPHQVVVKNLYLGINASDINYTNGKYVANMKPPFDVGFEALGQIVAVGSNIPKEKIGTYLTYSQYGAFGEYVITPYKRAIPVKSPRPELLGLLTSGLTASIALTVNGQMTKGETVLVTAAAGGAGQIAVQLAKLAGNHVIGTCSSDDKVAMLKSMGCDRVINYKKEDFEAVLKKEYPKGLDIVFESVGGKFFDVSLKRQVTQHDRSMSSYATADGMKGDKIDTLQLLGKSRTVTGFFMPAYENLFAEHMAGLVQLLDAGKLTVQLDTAGLSGIDSVVEAVEYLHSGKNKGKVVLPLTAKPQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N780</accession>
    <name>A0A162N780_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_114208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289818.1">
        <property type="nucleotide sequence ID" value="XM_018428376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N780"/>
    <dbReference type="GeneID" id="28989282"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_114208"/>
    <dbReference type="InParanoid" id="A0A162N780"/>
    <dbReference type="OrthoDB" id="2289199at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="264" mass="30656" checksum="F55E7C1B156DBA2F" modified="2016-07-06" version="1" fragment="single">ALMMVACDIPAARKTSGFTSHNSTCTCYKCNKHFPHLENDVNVDFRGFDFSRWVLRDGVENRLHAEKWESASTPSERHRLEVKNGVRWSQLHCLEYLDLVRGMIINPMHNLFLGTPKRLMDCWIKDKDIQDGDFAAIQKTAETMIVPGGYTSLNSKIGKQFLYMKADESKSWMLVYLSVLLKDALAKNRFENWINFVDACCLLIKPTITFDEVNTAYQFLQTFCTRCDELYNAEILTCNMHLHLHLRDTIHDFGPVYAYWLFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N7C8</accession>
    <name>A0A162N7C8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_152539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441003">
        <property type="protein sequence ID" value="OAD66464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284504.1">
        <property type="nucleotide sequence ID" value="XM_018432940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N7C8"/>
    <dbReference type="STRING" id="763407.A0A162N7C8"/>
    <dbReference type="GeneID" id="28993846"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152539"/>
    <dbReference type="InParanoid" id="A0A162N7C8"/>
    <dbReference type="OrthoDB" id="2261148at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="2">
        <location>
            <begin position="5"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD66464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="316" mass="36663" checksum="AA73CC618A91B1F3" modified="2016-07-06" version="1">MPRKEKSSLNLMVVGAPGSGKTSFLNTLSSHLNTYGHGITKPSQTQSDHLFRTTQLQWQDNKNLISLTLVDTPGFTETVLGYQAHYTKKYLEHQFDRVWMEEVKLKRNTKVQDTRIHVCLYFIDASITDFSPMEILLLREIAAHVSVVPVLAKSDLLSPEELAEKKQFIRNLLFDTYQIPVYGSSHIDTVEEDIMDWCVPDLTTRKSTWRPLKSYVEWLDQQHNENDEMEEAGQLKDYLEQMPFSVTFPKSLECSISSEEPSPGIDYSETMDLIQLLLANRDSFRHKTNAYFYEKYRTQKIFDERTDQLMAVHSCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N9A0</accession>
    <name>A0A162N9A0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_70394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD67034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285074.1">
        <property type="nucleotide sequence ID" value="XM_018442273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N9A0"/>
    <dbReference type="GeneID" id="29003179"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70394"/>
    <dbReference type="InParanoid" id="A0A162N9A0"/>
    <dbReference type="OrthoDB" id="2289675at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="268" mass="29101" checksum="3FBE0700EFE8E61A" modified="2016-07-06" version="1">MKEEEKKSTAFIIINSSSIRMASKDPLVRPVHCSLSSCVTNDSTDSFSVSTPLDASPTAPHSSPFSIITVVSTDEFSSSPYIPSIVAGVSRHRRNTNDNRSTQTVDPINPSTTLTTQSHSNQDALMIPNPEFEYANNASTSLSPFPSSSRPIPTTQDNPMWTRIKNRIIKKTRKSEPHYVTGSVTDTYSKSECEDQMMEPVSNQPTQSLNSESNSCGNRSGSGKCSDSRSVSGRCGGSGCGSNNSNSSSNPKRQRLSISWLNNIKTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NAX1</accession>
    <name>A0A162NAX1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cation-transporting P-type ATPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_86228</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285494.1">
        <property type="nucleotide sequence ID" value="XM_018443641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NAX1"/>
    <dbReference type="STRING" id="763407.A0A162NAX1"/>
    <dbReference type="GeneID" id="29004546"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_86228"/>
    <dbReference type="InParanoid" id="A0A162NAX1"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF20">
        <property type="entry name" value="P-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="715"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="783"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="10">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD67454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="808" mass="86836" checksum="ED5FDF97C63CA76A" modified="2016-07-06" version="1" fragment="single">LAMFSHSDPQNGLASASVASLRDHHGPNRLPDPPRPNALYMLWLQLTDLMVIILIIAAIIQCAEKEFNSAAVLLVVIVLNTIIGFSQEWKASKTLNALMNLSVPMAQVIRDGEQQMIGSEDLVPGDVVVLEEGEAVPADLRLIEVSQLELIESILTGESVPSSKSTDAVKAKSRRIPLGDCIGNAFMATTVARGRGKGIVVRTGVQTEIGKISTAIQKGSKRKTKTPIQRKLARLGLYLVALAVVLCALVVVIGIAWKKDVKTMVNIGLSLAVSVIPEGLVAVTTVTMALGVRRMATKHCIVRTLPAVESLGSVTVICSDKTGTLTQGKMGTSELWTADNALYRFTKSTSMDPSQGQILIEPAELHYSALRTHPLDPTNPSAYTSHLFYALMVAGLCNNSSIVLDEETGEYTPIGDPTEIALTVAAQKAGLGPAYWSQQVTKVFERAFDSERKLMSSIYASTDSNKSKNINDTSNEVYVLCKGAPEELTAYQAVPITEEFAALVADESSRMASQGLRVLGLGVKTAKLTQGWKDTASIESEPSLSEDELVFVGLIGLLDPPKQGVKEAVQVCQEAGIRVMMITGDHVQTATSIAAKLGIYQQGCRAILGRELDLLSEDALLELDPFPNVFARVSPDNKLTIVNALQQRGELVAMTGDGVNDAPAIKAADVGVAMGIAGTEITKQAADLVLLNDNFATIVAAVEEGRHVFDNILKFILYLLSCNGAEIFLMLICAIANLETPLTVMMILWANIIADVPPAMALGVEPKERDLMKRSPRNPKMGVLTKVSWTIIFFQSLMMAALTIGTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NB21</accession>
    <name>A0A162NB21_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="13">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_183524</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLI C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285534.1">
        <property type="nucleotide sequence ID" value="XM_018438787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NB21"/>
    <dbReference type="STRING" id="763407.A0A162NB21"/>
    <dbReference type="GeneID" id="28999693"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_183524"/>
    <dbReference type="InParanoid" id="A0A162NB21"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000032">
        <property type="entry name" value="Krueppel-like factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF8">
        <property type="entry name" value="GLIS FAMILY ZINC FINGER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="271"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="304"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="337"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD67494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="459" mass="51938" checksum="56A7CDE122EE3201" modified="2016-07-06" version="1">MDPTKETPTSPIFTVSPLYPLYPSSNMTINSPSPLLTDSPYAWMSHCDTATTNNTTTTTGSIPFTWMSQHQLDSPSMSSSTGVRTPDLPTCDTNYDNPDSFLAHTTVSPLWQPSTVSDDAIHATFYSDQKHYHHHHHEQHQHQQQLNWSSYAQDPLYDSYCLSNSSLLHLPFQESFDPAAYEALVVPSEVFPYPASVSPEMPTEWQSPESLVASPSPEMEFESSCYPVESKLASASALFGHLSRAELIERVVQLEKERQSRQPLVQEEKSYVCRWANCGIHLSKLNQLITHIKENHVGSGKPAYHCEWSDCPRNQKPFMKRHKMHNHMRTHTGERPFVCTVQGCDKRFSRPDSLNTHIKTHSNVRPYACPVRGCGKAYFHSRSLRKHGKSHETPMVARKPLGSLPKRANNQVQKTARRRYAMPRHVPDLRAIVAPRAWPNTAQVSSTSSSSAYVFSDYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NBF4</accession>
    <name>A0A162NBF4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_102253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285634.1">
        <property type="nucleotide sequence ID" value="XM_018427697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NBF4"/>
    <dbReference type="STRING" id="763407.A0A162NBF4"/>
    <dbReference type="GeneID" id="28988603"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_102253"/>
    <dbReference type="InParanoid" id="A0A162NBF4"/>
    <dbReference type="OrthoDB" id="3039677at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="177" mass="20292" checksum="63D8A42A9E277571" modified="2016-07-06" version="1" fragment="single">NLPRNERYKPENTLLVGSMPGPKEPKSEEINHYLWPMVDDLIRLYEGLAIPTFECPSGVRVRAALMMVTCDIPAARKTSGFTSHNSTCACYKCNRHFPRLENGVNVDFCGFDFSWWVLCDGVENRLHAEEWESASTPSERHRLEVENGVRWSQLHRLGYLDLVRGTIIDPMHNLFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NF05</accession>
    <name>A0A162NF05_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_172809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287014.1">
        <property type="nucleotide sequence ID" value="XM_018436875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NF05"/>
    <dbReference type="STRING" id="763407.A0A162NF05"/>
    <dbReference type="GeneID" id="28997781"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172809"/>
    <dbReference type="InParanoid" id="A0A162NF05"/>
    <dbReference type="OrthoDB" id="2357632at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="534"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="645" mass="72549" checksum="F246E44D652674FE" modified="2016-07-06" version="1">MSHRAATKSHYSHNSSTRNRNKSRNSRNDTNNESLYQELDHLLGVFCSEAQFNLCVSHRIASRQKLGKIRKVFKDIQQWLKCRAAHEVIKPSLYLSAEQYCNDLLAHYSIVSKQRHILPLQQQRMYHPLTQECTARLNHQWQALSEEFETATENNLLWQKYIFNIKQLVKAWKSPDLANQTLLSILTLREQPLPSPQQGKTPKNTLLSYTPKAASISSVSSISSSSSSLISPLSLPLSLSLSLSLSLSLSLSLSSSSFGRKRAAMSSYHITFTSQTNKEEQQRIIGRVCENFGSIFAHNATSNLSQVHSWIRHSQPSRVLKKVRQFKTNLYTEIGAESSHTKLATTKTETERKIKIKSAPPSAPPSAGPGKVLGSDAMMVNVNDNVDFNDSVNFDFNFNSNSNSNNNNVNSTPPQPTSVCTIGNTISQIENQDDNTDEENTEAEIVATSSKKGRKKDLLLPIPDFLLSLAEWESLRQIPGEKPRLKKYLKQPSLARLTGSFRALFSGASEHRAPSAQHHRQRQRQRQHQHQHQCQHQNQNQQEQQEQVTLPRNNDDTNTNNTNNTNNKDDNCSISVSKLGCILGRTGCKFYSSVLAHAQWCSAQDAHRLHTAGRDLVDLYGVLLLVTSQTQVQRILVLLSQIVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NGM1</accession>
    <name>A0A162NGM1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_64976</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD74028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292068.1">
        <property type="nucleotide sequence ID" value="XM_018441382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NGM1"/>
    <dbReference type="STRING" id="763407.A0A162NGM1"/>
    <dbReference type="GeneID" id="29002288"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64976"/>
    <dbReference type="InParanoid" id="A0A162NGM1"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="175"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="244"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD74028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="294" mass="32532" checksum="27474C70CA1331EE" modified="2016-07-06" version="1">MASPSLKIKLRLSRVNPESPGSNSIQSPDVPSPSLSAIAGQKHPKEDEEVPASKRPRPRAKKPVRKNDSNDIVSLRFLIADLMMIQLWGMTGDKQLISRSGASRKDILKFKDFKPRRWVNSNLVFRTLDGSSITLSGWQTEEQMTMNDKLTEPTTVAEIDQLFSSNGGEKDFRPFLCTQPGCSKSFTTYDQLQTHETNMHGTKKLICGIDNCHKSFVTTGQLTKHRKMVHFRAARKAKLAAAAAAEADNAREEGSDGGSHAPNTPNDTILHVNEEDEKTQDEDSVDIGISEDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NIE4</accession>
    <name>A0A162NIE4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_28503</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288014.1">
        <property type="nucleotide sequence ID" value="XM_018439929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NIE4"/>
    <dbReference type="FunCoup" id="A0A162NIE4">
        <property type="interactions" value="490"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NIE4"/>
    <dbReference type="GeneID" id="29000835"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_28503"/>
    <dbReference type="InParanoid" id="A0A162NIE4"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000067">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000007">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000039">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="216"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD69974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="438" mass="49130" checksum="AD9FF8359B72EB77" modified="2016-07-06" version="1">MGNAQSNLPRGNDKKQDKKQEKKKWEPPVPTRVGKKKKRGPDTIAKLPPVFPTTRCRLKMLKMERIKDYLLLEEEFVQNQEQLKPQEGRDEEERTRVDDLRGSPMGVGSLEEIIDDDHVIVSSSTGPEYYVSVMSFVDKDLLEPGCSVLLHHKTMSVVGVLADDADPMVSVMKLEKAPTESYADIGGLEQQIQEIKEAVELPLTHPELYEEMGIKPPKGVILYGVPGTGKTLLAKAVANQTSATFLRIVGSELIQKYLGDGPKLVRELFRVAEENAPSIVFIDEIDAIGTKRYDSTSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNKIDSLDPALIRPGRIDRKIEFPLPDVKTKRRIFGIHTSRMTLSEDVDLEEFVMSKDDLSGADIKAICTEAGLLALRERRMKVVAEDLRKAREKVLYRKSEGTPEGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NKP1</accession>
    <name>A0A162NKP1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_144459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293148.1">
        <property type="nucleotide sequence ID" value="XM_018431223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NKP1"/>
    <dbReference type="GeneID" id="28992129"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144459"/>
    <dbReference type="InParanoid" id="A0A162NKP1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="63" mass="6670" checksum="75DF168C91A83B6C" modified="2016-07-06" version="1">MPNHPHQVHLWITQCDCKITRIGEEDGTPTSDDSGSSGAGAGANTDVDADTDTDSFNVKTSHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PLI2</accession>
    <name>A0A162PLI2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_172063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD70046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288086.1">
        <property type="nucleotide sequence ID" value="XM_018436726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PLI2"/>
    <dbReference type="STRING" id="763407.A0A162PLI2"/>
    <dbReference type="GeneID" id="28997632"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172063"/>
    <dbReference type="InParanoid" id="A0A162PLI2"/>
    <dbReference type="OrthoDB" id="2285535at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="667" mass="77105" checksum="F7D361F9A2D46903" modified="2016-07-06" version="1">MFKSFILKKKLSIINKNKSEENVDDPFKVVKSSRAKRSQSSDLKEDKQAVNKRVTVHRDLMNALIIYHQSPRCLQNNLGFPYKDLKRELPFDIAVNNEYKELPINKIIITSNDLRNIIFRAMMFINSYCLAFSRDSIPNSIYKQAFWYSKIKLRAKGNTKAFYSFIFISIIIGSRIELPQKKVTKSANVPPDLVQSWDTHRASITNSVYNQSLQSESRQFLSEACTELATCYTNYIVENFEKRLLSYLRYTLQNLLVFVCGGDPSWPSRAPSLEELQKSSIINTCRLLKSHLPDKVTLAALSAHPEKHISVFLQILSEYELEHTSHNPFDARWLPLPRLFGLFSKPSFHFRSDLEPNGKNQIMFGNLIRSNGFSIDCLFYKRSPTPIEVRNRTLQLELSDFEFNEVQNYYKPVFVDLGRKVVFAAAEGLSIKAHSLLRCTIREYYHMTGSTRYQADQLQQKRQNGVEAIESHIPSHKRASQAAYIERVQYILTHLDVLYNFYGSSTAKSQFFLYQRCQKVPEQTVNILIHEDSKYSQKRRKKKAKKKKQEEPTNPKTLKPTSRQNEYNTSKTCNNCQAKNLESADHTRGPSVLVCKACNTLWLRAVNAAKYMMTVALSTWRGTHRPTASQISDKSKQTSSNYHNNPIIVPKLACLFEPFRQIDRLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PNM3</accession>
    <name>A0A162PNM3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_167954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292587.1">
        <property type="nucleotide sequence ID" value="XM_018435761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PNM3"/>
    <dbReference type="GeneID" id="28996667"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167954"/>
    <dbReference type="InParanoid" id="A0A162PNM3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="122" mass="13771" checksum="3CE2FD52C52FB2B5" modified="2016-07-06" version="1">MLICSATITLIQKLWSLMDPAPSPEGHLIDYALNCLPRSFKSPGTWCDWWLCLLSLLRVVDQTTSSYKLPEEKVHGQIFIDLAAKFRATKPTLLHRILPPTQEPVPGDLFPHLLSEISTIPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PPR7</accession>
    <name>A0A162PPR7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_158527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292877.1">
        <property type="nucleotide sequence ID" value="XM_018433804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PPR7"/>
    <dbReference type="GeneID" id="28994710"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_158527"/>
    <dbReference type="InParanoid" id="A0A162PPR7"/>
    <dbReference type="OrthoDB" id="2404451at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="124" mass="14326" checksum="8FA5F63D4A4D22D6" modified="2016-07-06" version="1">MFTCPYRNNRNVIVHSWLVGTVQFYFQHVDFYGFPHFLAFVEVMKEHDAAGHDSSVPIVKQWSQSTRTLGHQTQPTYAVISVNDICHQVGLVQYPPNGNQFYVIAPYYIFNNNMRITKGNLSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PRZ4</accession>
    <name>A0A162PRZ4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_169494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290396.1">
        <property type="nucleotide sequence ID" value="XM_018436082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PRZ4"/>
    <dbReference type="GeneID" id="28996988"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169494"/>
    <dbReference type="InParanoid" id="A0A162PRZ4"/>
    <dbReference type="OrthoDB" id="10435009at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="257" mass="28997" checksum="9BB82082B78B5DCA" modified="2016-07-06" version="1">MATTQSIALPLDFQISFDAPTDSFSADLMHQFDTRTSIIRNQVFTLADIPVLQPEEDRQIELPRVEEKEKEEEEEIKEPTVLKLKESIVVFEDPLADFLSGPDEPIRLFEPIQLITTPCPLENKHTRLTVHPTPVEEKHIIPQEIFSANDSNTSSDTNDHEEIFHMAVQEAPLTMLRKSSNFFRQKIQQIKSKDDSSLRSRRASLVPPLSSSSGVSQAESGSDLSSSPTVKSSPQISTQRSTLSSKRRSMFCLFLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PXJ3</accession>
    <name>A0A162PXJ3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dilute domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_78947</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293176.1">
        <property type="nucleotide sequence ID" value="XM_018443402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PXJ3"/>
    <dbReference type="STRING" id="763407.A0A162PXJ3"/>
    <dbReference type="GeneID" id="29004307"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_78947"/>
    <dbReference type="InParanoid" id="A0A162PXJ3"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15473">
        <property type="entry name" value="Myo5p-like_CBD_DIL_ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037986">
        <property type="entry name" value="Myo5p-like_CBD_DIL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="183"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="3">
        <location>
            <begin position="406"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="709"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="780"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="719"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD75136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="856" mass="95740" checksum="1F04E80DFF7E1D67" modified="2016-07-06" version="1">MIPEITAIEPETHAFSVLKSDSSQLDIQSIQPDNSKHIQSPVDTDTVRKQYENMSYDEMSQRMAESYKELSEMLGNRWSNPLSDITDTPSVTDDGEDELEEKEFTEADKKTKATKDFSRTVSSGDLTKVLALLQDENTRSLIDIDARDKDGTTPLIYAACFGKTEIAQALLTAGAKVDIQDSIGWSALMWATTNSHEALVKVLLAHGASSQQKTAKGRTAFDFVNTENHKIADILNTNPRDSMSSTSSAMGRTVYSSSSASSNAGDNDFYYYSTAEGVDNFLAEESDRRQHLMETAMALAGGTGDDDDEGDDGDEDYNYGDNDDDDNGDDIYNTFDWDSCMPHQMFVFNADHLNYILDTVITCIEVPLQSDQTSGEPASREKRQEMCVPANVVFLSARFAHYYSSSELLHNVLSGALARMSKYTKASSAHSCDLSVLAFWITNFSQLLYYLKKDAGLVAETADYQLALSELISETYTFIVNASCRRMTKLLESAMLDYEEIPGMEDIDFTDDWHRFFRRNPRRSAIMPDNGAMAMRRHSSLPAISSALEQTSPQSVTNILSTTFQVLQFYEVHPTIIIQVLCQFLHSMSCELFNRILTSKKRLSRSKALQVRMNLSHVEDWINHQRLPASLMSYLNPITQLLQLLQCVSQLDEPTLFIETVTKFDALNALQIKRCVMNYRYEVNEPRLPENIEHYVCQLAEDTVRFRQARQKGPDGRQRGSSMSRAQSVSIQRKRSRRESVSQFVGSLISSVNITASASLPPSIPTETAAAATAAATATATASPLPAAKEEASDDEDKQIKETKDSRFMLPFSVPTTAHMVHISGWAPEDSRREKIVVPVIPEEWMNTLDKGDQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q5D3</accession>
    <name>A0A162Q5D3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="2">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHYBLDRAFT_179449</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="2"/>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298276.1">
        <property type="nucleotide sequence ID" value="XM_018438146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q5D3"/>
    <dbReference type="FunCoup" id="A0A162Q5D3">
        <property type="interactions" value="1180"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162Q5D3"/>
    <dbReference type="GeneID" id="28999052"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179449"/>
    <dbReference type="InParanoid" id="A0A162Q5D3"/>
    <dbReference type="OrthoDB" id="1724632at2759"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000002">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000848">
        <property type="entry name" value="PRK00074.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6 14" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="15">
        <location>
            <begin position="211"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="239"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAD80236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="535" mass="59276" checksum="D8A92B43B5166D70" modified="2016-07-06" version="1">MAEAQLPQVNEMFDTVLILDFGSQYSHLITRRVREMGVYCELLPCTQKMSELHFKPKGIILSGSPYSVYDTDAPRVDPAVFESGVPILGICYGLQEMTNHMGGKVEACDHREYGHAMLNVIKHPNFPLADKLFEGLGDELKVWMSHGDQVTQAAPGFLVISKTNTAPFAAVAHESKPFFGIQFHPEVTHTDDGQAVLKNFVVNICHADASWTMDAFVDKEIARIRKIVGPHGRVVGAVSGGVDSTVAAKLMHEAIGDRFHAILVDNGVMRLNECANVKKMLGDKMGINIKVSDAADLFLGRLKGVTDPETKRKIIGNTFIEVFEAEAAIIDKECGGEIEYLLQGTLYPDVIESISFKGPSATIKTHHNVGGLLEDMKLKLIEPLRELFKDEVRALGKILGLDDELVWRHPFPGPGIAIRVLGEVTKEQVEIARLADNIYIEEIKKNGYYRQIAQAYAALLPIKAVGVMGDKRTYEQVIALRAVETKDFMTADIFASAEWFVCLKRISSRIINEVKGVNRVVYDISSKPPATIEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q7W6</accession>
    <name>A0A162Q7W6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_61890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298876.1">
        <property type="nucleotide sequence ID" value="XM_018440869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q7W6"/>
    <dbReference type="GeneID" id="29001775"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61890"/>
    <dbReference type="InParanoid" id="A0A162Q7W6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="141" mass="15810" checksum="F9EDE8F3F25BF57C" modified="2016-07-06" version="1">MFEIGIQAALISLKSGQEALLGHQEALEKKQDTMQLQMTSFYNEFKDREFPDRTIVTSTSLFHLFRILEQTLAGHCFLKRIKTGCVSIIPSYSETMESIIPDATETRHQLQGLASSGEGVRSENTLVSSYLVEILASTIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T3D9</accession>
    <name>A0A162T3D9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_160723</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441007">
        <property type="protein sequence ID" value="OAD65962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284002.1">
        <property type="nucleotide sequence ID" value="XM_018434239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T3D9"/>
    <dbReference type="FunCoup" id="A0A162T3D9">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162T3D9"/>
    <dbReference type="GeneID" id="28995145"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160723"/>
    <dbReference type="InParanoid" id="A0A162T3D9"/>
    <dbReference type="OrthoDB" id="275582at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059">
        <property type="entry name" value="RIBOSOMAL PROTEIN L23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD65962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="155" mass="17872" checksum="2CCC3C7A561A0101" modified="2016-07-06" version="1">MSTPFRQGLNKVYLPNIIFKMVKTPNLQSNQVAFRVPPSCNKFDIHSYLTNIYNVTVQEVRTMNYGTVHKKGRNGKIGVSETAYKKAIVTISEPFSFPKDPEWCALEREQNKVGSKMAGRKTKGWRFRGTEEERAKLKEVNEKVQARMEADQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T3I8</accession>
    <name>A0A162T3I8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">eRF1/Pelota-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_178482</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441007">
        <property type="protein sequence ID" value="OAD65992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284032.1">
        <property type="nucleotide sequence ID" value="XM_018437992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T3I8"/>
    <dbReference type="FunCoup" id="A0A162T3I8">
        <property type="interactions" value="996"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162T3I8"/>
    <dbReference type="GeneID" id="28998898"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_178482"/>
    <dbReference type="InParanoid" id="A0A162T3I8"/>
    <dbReference type="OrthoDB" id="10254527at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.960.10:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000006">
        <property type="entry name" value="Peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="5">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD65992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="436" mass="49108" checksum="CEE3A185B00E4EFB" modified="2016-07-06" version="1">MSQDNSDQNIEIWKMKRLIKSLEAARGNGTSMISLIIPPRDQVSRAVKMLADEYGTASNIKSRVNRLSVLSAITSTQQRLKLYNRVPENGLVVYCGTIVTDEGKEKKVNIDFEPHKPINTSLYLCDNKFHTEALSELLEADATFGFIVMDGNGSLFGTLSGNTRTVIHKLQVDLPKKHGRGGQSALRFSRLRDEKRHNYVRKIAELAVNFFVSADKVNVAGLVLAGSADFKTELSQSDLFDIRLQAKVVKVVDVSYGGENGFNQAIELSSDALSNVKFVQEKRLIQNYFNEISQDTGKYCFGVDDTLKALELGAVESLIVWEDLETNRYVLRDIEGVEHIIHPTKQEEKGREFLQDKCAEAAPNSEMELIEVKPLLEWFSEKYKDFGATLEYITNRSQEGSQFVKGFGGIGGILRYRVNFEALTYESDEFYSDEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TC25</accession>
    <name>A0A162TC25_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Acetyl-CoA C-acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_33195</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285502.1">
        <property type="nucleotide sequence ID" value="XM_018440008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TC25"/>
    <dbReference type="STRING" id="763407.A0A162TC25"/>
    <dbReference type="GeneID" id="29000914"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_33195"/>
    <dbReference type="InParanoid" id="A0A162TC25"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000010">
        <property type="entry name" value="Acetyl-CoA acetyltransferase (Thiolase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF107">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="6">
        <location>
            <begin position="6"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="7">
        <location>
            <begin position="273"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="4">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD67462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="41291" checksum="F1049D170A28A0D3" modified="2016-07-06" version="1">MALKQVFIVAAKRTPIGAFGGKLKDLTASELGGYASKAALATLPSNLPVDSVIFGNVLQTDVAGAYLARHVGHRAGLPVGVHALTVNRLCGSGFQSLINGAQEIQLGESDVVLTGGAESMSLAPYTLSGQSRWGTRLGVDLTLKDSLWTALTDQYPNPTPMGITAENLAEKYGITKDECDAYALLSQHRYEKAAAAGVYDAEIEGIEIKGRKGPELVSKDEHPRSGMTIENLTKLKPVFKKGGVTSAANSSGINDGAAAVVIASEDAILKHGLTPLARVVSWQSSGVEPTLMGIGPVPAIRGALARAKLTLDQMDIVEVNEAFAAQYLAVEKELGLVREKTNVNGGAIAIGHPLGASGARILTHLTHALQRTQSKYAIGSACIGGGQGIAVVLERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TEB8</accession>
    <name>A0A162TEB8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_152537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gonadal family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441003">
        <property type="protein sequence ID" value="OAD66463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284503.1">
        <property type="nucleotide sequence ID" value="XM_018432939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TEB8"/>
    <dbReference type="STRING" id="763407.A0A162TEB8"/>
    <dbReference type="GeneID" id="28993845"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152537"/>
    <dbReference type="InParanoid" id="A0A162TEB8"/>
    <dbReference type="OrthoDB" id="21617at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010849">
        <property type="entry name" value="Gonadal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13054">
        <property type="entry name" value="DIGEORGE SYNDROME CRITICAL REGION 6 DGCR6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13054:SF2">
        <property type="entry name" value="PROTEIN DGCR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07324">
        <property type="entry name" value="DGCR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="211" mass="24534" checksum="D1BEFA601E736A89" modified="2016-07-06" version="1">MDINQILSLLKTIPPAQPPVVEQPQIPTAIDLALIDQDVIDQVRNEYWAKQKASVKQEEEQDNSLDSLLVSLASATSITPDVLGAVARMVKETDILDIVKEMKDRQDQKEQEMFEHRQSIEERQKKERNGLFARELIGACKPEELETLEEKIKCELEQVDRHVLRSMDRERARQQIILEKRKVPFFRVTDKPSEMKMQQKMLSILLDMINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TH37</accession>
    <name>A0A162TH37_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_174477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441025">
        <property type="protein sequence ID" value="OAD67093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285133.1">
        <property type="nucleotide sequence ID" value="XM_018437256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TH37"/>
    <dbReference type="STRING" id="763407.A0A162TH37"/>
    <dbReference type="GeneID" id="28998162"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174477"/>
    <dbReference type="InParanoid" id="A0A162TH37"/>
    <dbReference type="OrthoDB" id="5545891at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617:SF3">
        <property type="entry name" value="CORE-BINDING (CB) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="887" mass="98780" checksum="F6EE83E62AA4F7B0" modified="2016-07-06" version="1">MTNDIHDTLQALPARMEALEARSAAPPVALDGSPADEDDTMLPTDHIVERPIASDLTPFPELSKAIPGMERDFFRQPLDEASRRRFLLNCPRNVLRQYQAPVLNYSGVGTHTKRTDAQLADIQFRLSGLTPPIDLFAHDVLVEGSIQVTQALGFANTMHELLSDLASVVTQMRSDNICRDANLPITPIVTNSALEPKPLLDSQRIVEQAKLQRALHGAARPSRTRKGKRTGQSNRTNKPTQSDPTSAIPSPTAVQVSDNQYTTVGGRLQLFRNAWTKLTNEHWVRRTVEQGYDIPFTRLPPISSSGPLTNHNRMDSNVIEQEIMSLLCKKAIKEQGYDTNHPSLQVERYPERSISPSPQPDNHLETAFLVHRQGPGNHFGSPSRAPANPATDIHAQPSLVPRIAMDQSDTPLFHGSAGTSVVDRPAEGMEWTLVPPRTSDVHDMEMGSASICDGRTFCTLDNLASPISLSAMEPTSPHTAETTTREGSSYVDNAQLVERPLVSSPPPAVVPPANPHPSSPGPSRTRLRRPRSPEEPTLEHDRVGHKLRRLEDQGFDDNANIIILNRDRNHSRQSYNRIQRAYIDWAHHHDVDPFIPNPVHIVNYLAYGATHLKWKASTCQAYRSAILDLYSDKDSIVKDSTYIEFFSALNEQNLLSFHRPTYDIAPVIRFIHNLGPNDTMNAIDLTRKLCWLLAICGFLRPADLERVDDHRTSRDNGILRLVIVAPKEKRSGRRIERVVAIQPHEDPLLCPVATYLAYKSNIAFSVCVRPHPVLSQVTLQRLVRDVRNYDRPIGSERISKHIQFLMEKIPRPSGALLPKARALGPTLALASGASVEDILVHGSWASSAVFDTFYRLSRQTVSNFSTMTLTSSSGYLDTQPESLANEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TK42</accession>
    <name>A0A162TK42_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_151292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285803.1">
        <property type="nucleotide sequence ID" value="XM_018432657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TK42"/>
    <dbReference type="STRING" id="763407.A0A162TK42"/>
    <dbReference type="GeneID" id="28993563"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151292"/>
    <dbReference type="InParanoid" id="A0A162TK42"/>
    <dbReference type="OrthoDB" id="2439011at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="275" mass="31302" checksum="04F293B48108D478" modified="2016-07-06" version="1">MNNLLREERMKPENIILVDVMSGSKEAKIDQMDNFLEPLVDELVELYGGITVKSAAFPNGTIVHAALMYVACDIPAARKTAGFTGHASTNACHKCERHFSVIARSSKIDYSGFDDESWVPRTKEMNAIYTDMWACAESNAERTDLEKQNGTQFSELHHLHYFDPIWCTIVDPMHNLFLGTAKHMISVWKDLGYLPAAVLVRMQRLADGIIVPPGYTVLSAKIELGFPYMKADEWQSWHLIYSLVILKDALPEKDFKYWTLFVKACQKLTSPHWKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TKB4</accession>
    <name>A0A162TKB4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_68177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285843.1">
        <property type="nucleotide sequence ID" value="XM_018441903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TKB4"/>
    <dbReference type="GeneID" id="29002809"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_68177"/>
    <dbReference type="InParanoid" id="A0A162TKB4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="182" mass="21155" checksum="BD26468F98E98487" modified="2016-07-06" version="1">MTQYNSLDAIPSYTGTHETERPIETVGADWRLPRRSAKVEKGGEQSTDVRSERHRQRLNNSNVLPRHIFVSSYITSYKYHASHCRQKITHFTIIVVQKDINKISILTNDAQNVTIPCPPRNFYWKKWRLVVIFTLGDYVSLQLLFECGDMSESVRLARTSEVRTGSTISKKYVPDKMEYLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TSE7</accession>
    <name>A0A162TSE7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Helix-loop-helix DNA-binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_66625</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287453.1">
        <property type="nucleotide sequence ID" value="XM_018441667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TSE7"/>
    <dbReference type="STRING" id="763407.A0A162TSE7"/>
    <dbReference type="GeneID" id="29002573"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_66625"/>
    <dbReference type="InParanoid" id="A0A162TSE7"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776">
        <property type="entry name" value="MIP04163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776:SF2">
        <property type="entry name" value="MIP04163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="267"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD69413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="375" mass="42901" checksum="6C06AF90936777FC" modified="2016-07-06" version="1">MTDSHLKLRNPTQYHLLATQDTMTGSFYDALHASDSFSMSEDQIDYGDSFSQQFLSPMTEPFHEFDDLDLDQDREKEKKRGHQLKNYSISQTLLGSSSAMDYTEQSPSDYSLASADFLSQPSCVGPMDIIHSNKTLAQDSYGQQQNQQQKHPMMMMSRSLFQRDPSSNFHGQQQDQQFQMDQLDQMDQLDQSTMFPMSAPANLGCQFGSHKLTLNPVPLNLSVTKSNPRDTPQSYEDDYNTQLVLQTMMEKRRRRRESHNAGNLSLINNLLIHLVERRRRENINDRIQELGTLLPDSMLEEINNSINSTNAGINSVNNKPNKGAILRKSVDHIRLLQEEVSAHVRRIKELEAILAQQANKLFFFRATDTTKSVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TX90</accession>
    <name>A0A162TX90_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_147489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289772.1">
        <property type="nucleotide sequence ID" value="XM_018431877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TX90"/>
    <dbReference type="GeneID" id="28992783"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_147489"/>
    <dbReference type="InParanoid" id="A0A162TX90"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="462" mass="50953" checksum="B4EF16EE0A68733B" modified="2016-07-06" version="1">MSSKHLNCESLVLSAQTDLSRMDASANTQADTSLETIGRICNVLATCSTALADAIEQNLSEERKNQIRQTITTIEGDLTILISAHGHLLHSSLSPAEQETHQSCVVPREMPIFQWQGNEWDTTQKVYSSIEECFEKLEDVLHSSPELHWSFARDAFICVYGINDLERQVQLTHELMLMRMRATESAKVADNMQAAIAYTATLLPELACQVSLLQVNMPREKWDTIEKAASLARSIYNTVPHTPTRPSSACSSSFFREITQSCERSSSKKCSLHGKGNHDTEDCCILKTALATKGGNWVEKTPHINKYVGSTPCCWCGEVWSCKHCCTSVSGSSSFLGSVSGSSQRSAPHFAVHSVYAVTNNSTFLEASSSEDDQSMVMNFEQCSPYTGATISSVNIKLCSKFEWLIIPCKRKIVLATFLDLAGNIDVSIATYLMLSLSIHLLGLAESWYSSTMANRGGFLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UBL3</accession>
    <name>A0A162UBL3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TECPR1-like DysF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_181393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291903.1">
        <property type="nucleotide sequence ID" value="XM_018438462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UBL3"/>
    <dbReference type="STRING" id="763407.A0A162UBL3"/>
    <dbReference type="GeneID" id="28999368"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_181393"/>
    <dbReference type="InParanoid" id="A0A162UBL3"/>
    <dbReference type="OrthoDB" id="72441at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TECPR1-like DysF" evidence="2">
        <location>
            <begin position="44"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD73863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="324" mass="38288" checksum="472C436620AEF96A" modified="2016-07-06" version="1">MTASISIRGENHQRAFHVKKPLKDFIHKPKQHPNSGPSLPLPSLPSHDRTKEEYVYDVLYECQRGSWIVGFSSKTLLQFDPDPWCDKDMRFTPMNIKTYQLPDPTWEWVHKQWMVDMTEDVDEAGWQYALKFHGASWHGKKPKERNDSDNFKGNYKHFRSFVRKRRWIRLRHHSLLDESITTTVSTNNTPEYQEQQLQLQSQPQPQQHIQQGHQGHQESQTTHKEQKLVESLQNSCLDRERLCYIKFALNGDRGYLSHMLMSKAKEYMEFFDFDVSRRNFVEILIQHQRSCGIPIDPKDIQPALKSITYYSDLQAILSQLKSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UGK7</accession>
    <name>A0A162UGK7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GBD/FH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_110012</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin homology family. BNI1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294122.1">
        <property type="nucleotide sequence ID" value="XM_018428147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UGK7"/>
    <dbReference type="STRING" id="763407.A0A162UGK7"/>
    <dbReference type="GeneID" id="28989053"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_110012"/>
    <dbReference type="InParanoid" id="A0A162UGK7"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="450"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD76082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="481" mass="55013" checksum="909EE96E00700760" modified="2016-07-06" version="1" fragment="single">MVAQDIQAEAGPTPNASLSTRRGVSADRHKEQENSPEYYVKKLSEIGSKGYSSKVISHLAVGLRTMPLSWVRQFIEMSGLLIITDTLSALNRLKHKREIEVQTEGEILKCFKALLNNRIGAKEAIKNPQCIQEIVYCIVSPAVNTRRLVCEVLVFLCYFSVPVGQELVLRAMDNLRDARKGYGRFDAWLKDLLYTLGGRGRMGSMVGASEDFKRLATHGAPDNQLSEFALYNMILVNAIVNVVEDPEIRIHLRNQMNVSGLERIMDRMLDLCCDQVDRQVQEFRTLAENDHDEIMELYHERVLRDLNDPRDVFECVLASVEGTRGYDFFLSSLQHLLLIHEEGNLKARYFQIIDNLITQVVLDHKGLVDDFSSSYGTSVRHLVDKFADQDQLQATIEEIRQLQTMYDELQVEHNAAQQQLIERGDGLAITQLKEKTTSLEDLLRMSRHTISTLQGKLRDLQRDYEKNLEAMEKQLDTFYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UN72</accession>
    <name>A0A162UN72_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_142026</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294543.1">
        <property type="nucleotide sequence ID" value="XM_018430730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UN72"/>
    <dbReference type="FunCoup" id="A0A162UN72">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UN72"/>
    <dbReference type="GeneID" id="28991636"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_142026"/>
    <dbReference type="InParanoid" id="A0A162UN72"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15534">
        <property type="entry name" value="PHD2_PHF12_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052819">
        <property type="entry name" value="Chromatin_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="76"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="363"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="427"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="365"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD76503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="534" mass="60460" checksum="4DC9DB96A7B9DEE5" modified="2016-07-06" version="1">MSSVRSGSLRIRSANRGKIAGAALQRQKVTTQEPPKSPAVKKRKKPEAEAPPKRAVRRKTEKKSQSEKDIEDAKNNDYCDACGGLGRFLCCDACPKAFHFTCMEPPMEEEEVERIEGQWFCNECQNKQDNNTISDSDSGSGSGSGSGSGSGSGSITISDKRSSERYRKNGLFEALLQDLKGRNPKAFSLPKEIRTFFTGGEYVDSTTVKAVRYRNGQREEPDYRQLKDKNGKFIVCYKCRKTAVSAPIVGCDYCPLYWHMDCLDPPMCIPPNISRKWMCPNHAEHPKRRIQRRPLIIEPKFPQSTNNGDIEIVSDDSTDSIDTLDDMDSFDQLASCGGVVYRLPAKAIQTDFMEYAKSLRHAHQRSTTAETLSKATSPLSHPSPEPFLPSPQTLDGSQDPTDKATEGEAKEWLESLLFFQTSGEEYQKHNNDHDHDHDHDQKNDLSHDHDFNYQQPEQGMDESSEQNTNVDQVGLHALLHAIFHDKYDKQDDTPKSKRRKVEIDQDRYEKCLRIEELLRRKGEEALMKILTTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UW55</accession>
    <name>A0A162UW55_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_107289</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296432.1">
        <property type="nucleotide sequence ID" value="XM_018427991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UW55"/>
    <dbReference type="FunCoup" id="A0A162UW55">
        <property type="interactions" value="606"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UW55"/>
    <dbReference type="GeneID" id="28988897"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_107289"/>
    <dbReference type="InParanoid" id="A0A162UW55"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12306">
        <property type="entry name" value="RRM_II_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF12">
        <property type="entry name" value="EUKARYOTIC INITIATION FACTOR 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="43"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD78392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="161" mass="17811" checksum="200367EFE9DFC3EB" modified="2016-07-06" version="1" fragment="single">ELEAMKVRVQEMEDEAAKLRSMQAEVEKTMSTEEVDREAVDSRSVYVGNVDYGATPEELQAHFQSCGTINRVTILCDKFTGHPKGFAYIEFAEPSFIDAAVALSESLFRGRLLKVSAKRTNVPGFSHRGGRGRGGFRGGFRGGMAPYYGHSPMHGYRGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V4W7</accession>
    <name>A0A162V4W7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CCT-theta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_121605</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298023.1">
        <property type="nucleotide sequence ID" value="XM_018428816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V4W7"/>
    <dbReference type="FunCoup" id="A0A162V4W7">
        <property type="interactions" value="863"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162V4W7"/>
    <dbReference type="GeneID" id="28989722"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_121605"/>
    <dbReference type="InParanoid" id="A0A162V4W7"/>
    <dbReference type="OrthoDB" id="1748577at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD79983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="549" mass="60168" checksum="152C04ED5B2B58F3" modified="2016-07-06" version="1">MALRVPKSTLPQLFKEGYKFQQGVDEAVMRNIEATHELSEVVRTSMGPNGRNKMIINHLEKLFVTNDAATIIRELDVVHPAAKLLVMASQQQESEIGDNTNFVIVLAGALLQKAEHLLRLGLHPSEIVQGFELARDRALAIIEELSVDKIETLSNKENLLKITKAAIASKQYGHEELLSGLVTEAALSIMPKNQRDFNVDNIRVVKVMGSSIYESRVVRGMVFGREPEGTIQNVKKAKVAVFTCPLDITQTETKGTVLIHNAKEMLDFSKDEEKHIEKIFKELSDAGVNVVVTGNGIGELALHYLNRFNIMAIKVLSKFDIRRLCRVVGATALARLGAPMPEEMGYCDIVETVEIGSDRVTVFRQEQSEVSRTATIVIRGATQNHMDDIERAIDDGVNIIKACARDGRLLAGAGAVEMELNKRLQNVAAKTPGLNQHAIKKFAEALEVVPRTLCENAGMDAVAVLSRLYAAHYQEGDKGNSIGVDVENENDGTLDATKAGIYDTVAGKQLALKLASDTAITVLRVDQIIMSKPAGGPKPPKNQGHWDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V9Q9</accession>
    <name>A0A162V9Q9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_8303</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299102.1">
        <property type="nucleotide sequence ID" value="XM_018443609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V9Q9"/>
    <dbReference type="STRING" id="763407.A0A162V9Q9"/>
    <dbReference type="GeneID" id="29004514"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_8303"/>
    <dbReference type="InParanoid" id="A0A162V9Q9"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD81062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="89" mass="10011" checksum="A0A0BC2124CEFC08" modified="2016-07-06" version="1" fragment="single">TNLYIKNLDSSITSDDLKPLFNKFGKIVSARVMSNPFTGVSKGYGFVSYGKSEEARAARDEMDNVMVRGKPLIVAYHEPKKGRQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WIV1</accession>
    <name>A0A162WIV1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 18 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_101903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285465.1">
        <property type="nucleotide sequence ID" value="XM_018427649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WIV1"/>
    <dbReference type="STRING" id="763407.A0A162WIV1"/>
    <dbReference type="GeneID" id="28988555"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_101903"/>
    <dbReference type="InParanoid" id="A0A162WIV1"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF392">
        <property type="entry name" value="HAP41P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="1">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="183" mass="20260" checksum="3CE817533E3351E9" modified="2016-07-06" version="1" fragment="single">NTKVLLSVGGWTGSQMFSPMVTTHEGRKKFIDWNLDFIKKYNTDGVDIDWEYPAKGAAACNKFTPGDSQHLLSLLKELRAALDQKFPKERKLISMAVHVEPFVGKNGPMKNVSAFVPYFDHINIMTYDINGAWASVTGPNAPFKAEPGRPEVYSYTSAIQAWKNAGVPAEKITAGLAFYGRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162X6J3</accession>
    <name>A0A162X6J3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Benzoquinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_125211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290855.1">
        <property type="nucleotide sequence ID" value="XM_018429037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162X6J3"/>
    <dbReference type="FunCoup" id="A0A162X6J3">
        <property type="interactions" value="148"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162X6J3"/>
    <dbReference type="GeneID" id="28989943"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_125211"/>
    <dbReference type="InParanoid" id="A0A162X6J3"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD72815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="204" mass="21748" checksum="235CE6515295F1B8" modified="2016-07-06" version="1">MVAKIHIVIYTLYHHIYTLALEVQKGLLASGIQAEIFQVPETLSDEILTKMHAPPKPNVPIITTEKLTEADGIIFGFGTRFGTMPAQVKAFLDSTGKLWSTGALAGKFAGTFFSTAAQSGGQETTAFTTITYFAHHGMIYVPLGFASPHLFDTSEVIGGSPYGSGTVANGDGSRQVSQKEKEIAQTQGENFGKVVKTFVAGKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y5L5</accession>
    <name>A0A162Y5L5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_163537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296465.1">
        <property type="nucleotide sequence ID" value="XM_018434817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y5L5"/>
    <dbReference type="GeneID" id="28995723"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_163537"/>
    <dbReference type="InParanoid" id="A0A162Y5L5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007840931" evidence="1">
        <location>
            <begin position="24"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="219" mass="24994" checksum="8FF52566CAAF11D0" modified="2016-07-06" version="1">MLLLVYNALLMIFLFLLNIPSYSKKVASEFLYMKAGVAQVLSESHIPCLQCIDNGYHPAFPFGLPMFQQVVNSLWYNVIGTKASPPTTMPLKLQHLNTMNISLGENVLVNICIQKMKNISLLGQEFFSEQKKCRSSIVRLTTSPNSLVRLNTYLLVIKIGRIKSVNVWFFKKICDAILSELSVIWIRSEFVVNSIINEYFYQNKLTESDITISNEKNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YKD0</accession>
    <name>A0A162YKD0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_161899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299325.1">
        <property type="nucleotide sequence ID" value="XM_018434522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YKD0"/>
    <dbReference type="STRING" id="763407.A0A162YKD0"/>
    <dbReference type="GeneID" id="28995428"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161899"/>
    <dbReference type="InParanoid" id="A0A162YKD0"/>
    <dbReference type="OrthoDB" id="3247418at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="674" mass="77922" checksum="215D3141DCBC053D" modified="2016-07-06" version="1">MAPIRKPTVRKECRCSIYKSKTLEFDCVSVKTFKRHQEKDNHDITHVQMPHEDTCDTISSAVSEPVNQEEDSFEFEQEDVEMNSELRNLSDTNDILDIRTRNQPFSETDCMFGFEDNVQYTSDTYEEEEEYEDESDVEMDNDEGAVILIAIINEILQFLFDPFRLPVSVAGLKRLARFEALTSGVKKYVACSKCHAIYDNEAAPLCCTSPNFGTAKRMLERWVADGLINNKKLVAMQKAVEKVVLQPDYTSLGTKIAKGFPYMKADEWKFWCLVYSPVVLRDVLLLPEFKNWIEFVNTCRYFTKPSVSEEDIEKGHKCLEEFCKGCETLYDLDLLSPNMHLHLHLCQTMIDFGPVYGYWLFSFERYNSVLKNIKTNRRNGFESTFMRQFIEESWKGDFVCQLLKPMHALACFEIFDKFTTNNNNTNTNTNTNTNTNTYLSYSFSISKYLEASQNLSMTIRGNEPLLLSALPLKTRPLSFMPKHEYDCLVGYYQAAYKNPQISGCKDVIDDSPFVNDWIEKVKFVDLLGQSYKGCIGKNGHGSYIQAYFTERTGSEYAYVEEIQYLFVHNFRPTVSSLTYRNPHSSQHVFAFVKWFKSTSDKTRELEGVKLLQEEFYKQDFQSILTEHSKKENVYSSLIAQRGNDWDRVAGTEQGNNVAGYLFILGFVPMPAFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZB14</accession>
    <name>A0A162ZB14_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor CBF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_120088</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441010">
        <property type="protein sequence ID" value="OAD65541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283581.1">
        <property type="nucleotide sequence ID" value="XM_018428726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZB14"/>
    <dbReference type="FunCoup" id="A0A162ZB14">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162ZB14"/>
    <dbReference type="GeneID" id="28989632"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_120088"/>
    <dbReference type="InParanoid" id="A0A162ZB14"/>
    <dbReference type="OrthoDB" id="1272441at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000006">
        <property type="entry name" value="Nuclear transcription factor Y subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF8">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="8">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD65541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="111" mass="12740" checksum="CED75654859170F7" modified="2016-07-06" version="1">MAENFDSDFKNHPLPLARIKKVMKTDQDVKMISAEAPILFAKGCEIFIAELTRRAWVHAEENKRRTLQRSDIATAISKTDMCDFLIDIVPREEAAKTTDAVRDFIIINIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZHK4</accession>
    <name>A0A162ZHK4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_70206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441000">
        <property type="protein sequence ID" value="OAD66801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284841.1">
        <property type="nucleotide sequence ID" value="XM_018442235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZHK4"/>
    <dbReference type="STRING" id="763407.A0A162ZHK4"/>
    <dbReference type="GeneID" id="29003141"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70206"/>
    <dbReference type="InParanoid" id="A0A162ZHK4"/>
    <dbReference type="OrthoDB" id="2447509at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="447"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="562" mass="64260" checksum="1A39FA9D4F9DD4C6" modified="2016-07-06" version="1">MLGHSRSTHKQCLMNPKNISLHIPQKRTNVDEYSAESSRTAVLRIRSEPVQDQNLDIETLTSLSVSELTEFLLANETITEVLEAVMEEEIEETSSNKEVTGREEEVEEISTVNRGSILPHCPHCNGTDHCQITSRFCPNNNSSRARGSRNRGRGLNNIARLPAISEPAVDNRRDMDIECRFCGAMMWAHEKNSHSSLRSPTFSMCCNKGKHVLPQIVLTPTGIAELLNYRTRNGKKFLENIRSYNSTMSFTSLGAKIDTSVGNNINGAYNFRIHRTICHRIGSILPVTESDITHLKFAQIYIYDSAAQIDQRQYHSPQLERSVLEKIQPILMETNPFVHLFRTMDQISQEKGQSIDLTLRLVAEGPRDQRRYNAPTASEIAVLIMNNEEGTSRDIVLHTRANFQQNINEYHRSYDALHYVLLFPHGEDGWTIDASSLSGEHVTVMQWYSNCLMYQRNTQHLLHLFGRLFRQYIVDMYAKVEHDRLHFITSNQNRLCVDLYSGILDAVIHNNCNLANLGKRVILPSSFISSPRYMAQLYQDSMSIMRRFGKPDLFITFTCNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZJC2</accession>
    <name>A0A162ZJC2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_118650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441025">
        <property type="protein sequence ID" value="OAD67211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285251.1">
        <property type="nucleotide sequence ID" value="XM_018428645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZJC2"/>
    <dbReference type="STRING" id="763407.A0A162ZJC2"/>
    <dbReference type="GeneID" id="28989551"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_118650"/>
    <dbReference type="InParanoid" id="A0A162ZJC2"/>
    <dbReference type="OrthoDB" id="5560525at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF0">
        <property type="entry name" value="SEC2P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="3">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD67211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="121" mass="14116" checksum="42317082EB969A39" modified="2016-07-06" version="1" fragment="single">MYEEELADLQNKLGIEQAKISEQLAEIDALGRTLEDVEQRLDAKSEEFAALQSDMELLNDKYVDEIERVAEIQHSKDMVESELEDLSRRLFEEANGMVANEKREKYNLEMAQKHLENQLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZUJ4</accession>
    <name>A0A162ZUJ4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_150103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD69111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287151.1">
        <property type="nucleotide sequence ID" value="XM_018432403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZUJ4"/>
    <dbReference type="GeneID" id="28993309"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150103"/>
    <dbReference type="InParanoid" id="A0A162ZUJ4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="193" mass="21475" checksum="EF4B152A6FC725F4" modified="2016-07-06" version="1">MPTPNCRLAPSLASTDVQLLQALNAMKEEMKAMKDKITLMDTRIGVVITSNATAINGIDALSALPASAHVPTSVASTSAALPITESSDTNAVFGYIHGYMWNPKLKSRDQAEIQANAIKPKWAVDVRFDRSPNRELVKQLLYYLEKKFADTDMRTRNLSLNTNSRRSGRETDNYTHHRLAYDAYKADIDLKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ALF1</accession>
    <name>A0A163ALF1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_167726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292351.1">
        <property type="nucleotide sequence ID" value="XM_018435701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ALF1"/>
    <dbReference type="GeneID" id="28996607"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167726"/>
    <dbReference type="InParanoid" id="A0A163ALF1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="237" mass="27589" checksum="DD973F64E4DB6291" modified="2016-07-06" version="1">MSDINTTLLNSIQKIEVDLAEIKQALREFQRQFSNQFAPAVSAEYLTTMQQSIIEQSSLERIAKSVKRAQLTEYPDQLAQKYNLLLQILQEQDWKARYKEVPQGQPLPPLVPLSDHDLTVKRLHLKTLGRMVKHDIIDKDYPAASKEWKNIPEKNREYYMMHLERLAKNGGLHIHQCKRMWCARSLLRKSFKSDNQTHKRRMAEKNKMCCLLHPQQVSSLLAREAEDRSLAAVIGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ALH2</accession>
    <name>A0A163ALH2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_167738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292361.1">
        <property type="nucleotide sequence ID" value="XM_018435706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ALH2"/>
    <dbReference type="GeneID" id="28996612"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167738"/>
    <dbReference type="InParanoid" id="A0A163ALH2"/>
    <dbReference type="OrthoDB" id="2286816at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="143" mass="17090" checksum="0000A238D0A8CE44" modified="2016-07-06" version="1">MTETHVDFIPIRTNKIPSATARINALINYLWKKKQETDISIFLEEQKLIQLQFHMSTRQCHHIMHKDGINMLAKLSREVQEEELSSIDEAETNLLNNLRMQTNYKYFDFNHNYLKLLMNILELYTTLEQNCLNIILIEKHQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AMD5</accession>
    <name>A0A163AMD5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_177474</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292531.1">
        <property type="nucleotide sequence ID" value="XM_018437891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AMD5"/>
    <dbReference type="FunCoup" id="A0A163AMD5">
        <property type="interactions" value="342"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163AMD5"/>
    <dbReference type="GeneID" id="28998797"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_177474"/>
    <dbReference type="InParanoid" id="A0A163AMD5"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="52"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD74491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="556" mass="61700" checksum="6C177BF70260C58C" modified="2016-07-06" version="1">MSLNTKYEAKRPPPDIETFSTRAASHFDEKIDDEKIHSGIKGLIANPYVFATAIFASLGGVLFGYDQGVISGVQEMETFKDRFPMSPTENGFVVSILELGCWVGAWLVGYFADRISRKYSIVLFSAVFLVGSSLQGAAQNLSYLLSGRFVTGLAVGGLSMLVPLYQSEIAPPEIRGSLVSLQQLAVTFGILISFWIDYGTANLSTEAQWRIPLCLQLAIGLVLGVGILFFPHSPRWLMSVGKEEQALQVLSKLRRLPDHHPKVIKEWREIKINVTFDKLVEIETYPDYVDAGTSGRFKIFMMGYVELFRKGMRNRLFIACAIQFFQQFVGINALIYYAPKIFQSVGLTGSSVSLLATGVVGVINFLMTIPTVLFLDMVGRKKMLMIASVGLSVSMIIVAIITGLYEDDWPNHTAEGWVAVVFVYIFIANFAYSWGPIGWVIPSEIFPLRARAKAMSISTSANWMCNFIMGMITPPMLAGIHYGTYVFLAVFCVLSFLFTWFFIPETKGLSLEEMDNIFGGDMANSDSNLMSRVREEVHQQGVPARPVDTTSDSRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AQA0</accession>
    <name>A0A163AQA0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_144405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293091.1">
        <property type="nucleotide sequence ID" value="XM_018431215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AQA0"/>
    <dbReference type="STRING" id="763407.A0A163AQA0"/>
    <dbReference type="GeneID" id="28992121"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144405"/>
    <dbReference type="InParanoid" id="A0A163AQA0"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF10">
        <property type="entry name" value="LD21067P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="2">
        <location>
            <begin position="193"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD75051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="481" mass="53859" checksum="44AA7EBE178BEF0C" modified="2016-07-06" version="1">MSTSPIVTELPLGAISDHLVIFIHGMGKQYEDSGNIEHHVATMQKHTKEVLQTQFPSHQLRVKYVPVEWHSVVHLLVDTKMDQSSLGTIPKVRLATNHWLLDCMYYFTKPHNQCIIDTICEQSNKIYQKHLIDYPDFEENQGQVHMVGCSLGGVAGYDIASSQWLPEDGLPPWDGVQDKQYVCARPDVNVPKLDFNVKSLFTCGSPIAAGLIFRGLDYMHFRPPPRTRVFNIFHPFDPLGYRLEPMINDSYTTIDPVKIQRAQRKALLSVNIPKIPNLGIRSSFAGAGPMITRAGKTFWRYLNAETQPVESQALDVSKSTWEPTLDDENNIKHPIPHSSTSLDSSTSSNSSTNSRSGTSNNNSDSNSSRNIVLPIDIWLVEQPSPDMSYSTSTVGEESGSDSEGSAIDCDPAIGLKEKDLPELSTHITGRDGNHYARTDYVLSENVIDAYASEWLIAMKSHFRYWANRDLALHIVQTMIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ARK7</accession>
    <name>A0A163ARK7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type zinc finger transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_64218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293331.1">
        <property type="nucleotide sequence ID" value="XM_018441257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ARK7"/>
    <dbReference type="GeneID" id="29002163"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64218"/>
    <dbReference type="InParanoid" id="A0A163ARK7"/>
    <dbReference type="OrthoDB" id="2263388at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="773" mass="88783" checksum="CDC9CFFAC92564C1" modified="2016-07-06" version="1">MNPSNKRARSPNDISSYICDICNLDCFTSKQLWNHKRIYKQNTGSTFSASSSTHVHLENEDLSPPVDDYMTEDIPFDPFKPRTYKAFCNFEAGDEGHVYNDNIFTENTFTTSQLLSIELYDIVTSFNVSTECHRQLANLMNTVFWDHDKLSKEYSPEILQAGPVNTLLKNKAAIKAHAYVICMNACRLYNNTQNKEECPHCGSKRFMEATDNTLTHLVPVKTMKMILLGNSDTRKKLHYRANRQLISSELSDYFDGEEYKALKTQHFFQSPDDVAVALFLDGFQLTIVHVMILNYDPLIRYTNEYLILLAIIPGKPVDLDSFLLPIIDEVISLGKYGLIIKKFDGERIAAKVHMEYVLRCNKSNNQVSGSPQHLETFLKLQSIVIIKVIIPDMDVAGRGMYFKNCRAPLRPMIDFVNGNPNTSIQESNIFARLPTFTGSSFYGLDEMHLIGNVPTLLVPLFSKAATRKALLALVKGCSISLQWNLNEELIVEMEKKMGNLRVYSTRSMERTIGRYSKLIKSRVFSGKNARNLVERLAIRGYLNCAFNIEQQLDLIKPYRTSLDNYLELPLPSPHNQNHQLWSPFESIPYIKEFTDLPTFTKELQIYYTKSNSHSTDPQYTMNTIKIAACALISSHVYGSEMYRRKRSEFQRGNHYIQFHAIYQNKIHWFVSSVIFYFTHNILPHDKSCRQFLVLVSVMNDHSATDYNYSIPVVTLERASIYQRLVVISLNDIQNQVGLVQTAVNSTKYKVVAPYYIFSEDMKSTAGKLRYIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ATJ7</accession>
    <name>A0A163ATJ7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_166929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293741.1">
        <property type="nucleotide sequence ID" value="XM_018435529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ATJ7"/>
    <dbReference type="GeneID" id="28996435"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166929"/>
    <dbReference type="InParanoid" id="A0A163ATJ7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="231" mass="25614" checksum="D5422AF6357969DF" modified="2016-07-06" version="1">MNSTTKTCTVICTCLSCTKNAIGGILQNAQTFKRHNNDDKLLDIGPKNRVNTEVVEEETDVEMVDVSETSIDSKTTVQSVPFLREDEIFQFEESDVETTSLASDNDDPDSSDESEDESEVEVAGVEDFEDMVASEILAFVVASLKIHEISQTSQFMALFGIIFQAFYLVQAGGTAMLKFFCHLLVAFDKNANLPLTIDALKTMTGFNFMTKSIVKYTVCNKCFAIYLPGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B3K2</accession>
    <name>A0A163B3K2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_141977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD78111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296151.1">
        <property type="nucleotide sequence ID" value="XM_018430714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B3K2"/>
    <dbReference type="GeneID" id="28991620"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141977"/>
    <dbReference type="InParanoid" id="A0A163B3K2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="85" mass="9122" checksum="F8F5CDB5471CE8FD" modified="2016-07-06" version="1" fragment="single">MTNTRRERAIALRPVEITNQQLMEILSTVRADMSTVKGQIGNVEQTLTNMNGRIGVLATTSTNTISAIDSLARTPLAAPGEPNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BBP9</accession>
    <name>A0A163BBP9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_162555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297531.1">
        <property type="nucleotide sequence ID" value="XM_018434650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BBP9"/>
    <dbReference type="GeneID" id="28995556"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162555"/>
    <dbReference type="InParanoid" id="A0A163BBP9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD79491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="179" mass="20329" checksum="210D834AFEED2EA0" modified="2016-07-06" version="1">MWYVVIAAIIIKTTNPILQGIQETLFALQKGQEELQIGQDTLKKGQEAFQKEQALLRQEITNICKDMNGQESPEPTIVHNNLGLAIPRPVPNIKDITLVHIYRIMSHDIGVELDKRNKAILHTCTDLVCDELATLPSVQALEQYPNWSAISQEDENWVCTRHACLLRNSSTDFTRCHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BBS8</accession>
    <name>A0A163BBS8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_58561</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SYF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297551.1">
        <property type="nucleotide sequence ID" value="XM_018440350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BBS8"/>
    <dbReference type="FunCoup" id="A0A163BBS8">
        <property type="interactions" value="393"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163BBS8"/>
    <dbReference type="GeneID" id="29001256"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_58561"/>
    <dbReference type="InParanoid" id="A0A163BBS8"/>
    <dbReference type="OrthoDB" id="199717at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="169"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD79511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="407" mass="46606" checksum="2D7833F8A6C1F451" modified="2016-07-06" version="1">MPPKRKTRAAAAAAAAAAEDTTTTTTLDKKETETPVVSQKSIPTKTETITETIVEETTETSKGKRKRTTTQSKVTVTVDNSAQDASEESEQNVGSDDTKMIESNDKTNENEKSQNLESGSTTSVNNNNDENSTDNSNDDNNDDEAQPATPKGALAERMEKLKALKRRRVTEVEQGNRRDRNLEFQRSKENPRLDARNERKKQESLKLKEKQDAKDNGEDYERKQFWKYSAESVDSWEKKMAKKAKMANNGFTERKKKKNKKKPLDPPYTQTFTLLLFVDHTQAAHKKYIKLMSDFKPDMNSYAEKKLESIERAIRNGEDPSDFASAANNLEYASVTDKTSKEAIERLAQDTKKQIIQRETRSRDRKESSDDISWINEKNRVFNQKISRFYDKYTREIRENLERGTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163CSQ2</accession>
    <name>A0A163CSQ2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_71048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441029">
        <property type="protein sequence ID" value="OAD65340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283380.1">
        <property type="nucleotide sequence ID" value="XM_018442397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163CSQ2"/>
    <dbReference type="STRING" id="763407.A0A163CSQ2"/>
    <dbReference type="GeneID" id="29003303"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71048"/>
    <dbReference type="InParanoid" id="A0A163CSQ2"/>
    <dbReference type="OrthoDB" id="2285345at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="20046" checksum="6F405D1100F23B18" modified="2016-07-06" version="1">MTRDYNNHVPEDRSEIRTLALPFEAIKLIEDQLRSGSSCRSTRISVLQQIDSWGVGSLYLTVLMTNLLYMFNSDEKAFIAIWMNKKLPERNYCIFTRDLRVNNIESNLFAFGFQLPAQVRVMRIATSFCLDATHNISARSGEVIYSLVTQHNITGKGFPVVYMVTNDQTVRPISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DB16</accession>
    <name>A0A163DB16_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_115470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288120.1">
        <property type="nucleotide sequence ID" value="XM_018428466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DB16"/>
    <dbReference type="GeneID" id="28989372"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_115470"/>
    <dbReference type="InParanoid" id="A0A163DB16"/>
    <dbReference type="OrthoDB" id="2439011at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="166" mass="19471" checksum="9FC9EA2031DA6C0D" modified="2016-07-06" version="1" fragment="single">AEVWKNAIMHAERHRLKVANNVCWSELHCLQYFDIVCCTIIDPMHNLFLGTAKRMMERWLADKLIDDKKLIAMQKAVKKVVLLPDYMSLGTKIAKGFPYMKADEWISWCHVYSPIVLRDMLLLPEFKNWIESVNVCRYFTKPSVSEEDIKNGHICLEKFCNECETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DUH8</accession>
    <name>A0A163DUH8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Serine/threonine protein kinase AGC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PKB2</name>
        <name evidence="11" type="ORF">PHYBLDRAFT_26159</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291530.1">
        <property type="nucleotide sequence ID" value="XM_018439884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DUH8"/>
    <dbReference type="STRING" id="763407.A0A163DUH8"/>
    <dbReference type="GeneID" id="29000790"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_26159"/>
    <dbReference type="InParanoid" id="A0A163DUH8"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="7"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="10">
        <location>
            <begin position="271"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD73490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="304" mass="34739" checksum="78EF8C27AFF84B37" modified="2016-07-06" version="1" fragment="single">PFLLDNLEILKVLGKGCMGKVFLVRSRTTQELRALKSIVKDLVIEQREITHTLAEREILATVAAIDHPFLAKLHASFQDEHRLYLITDYYCGGDLATQMSTCYTFTPERVLFYAAEIIDGIGELHRLGVLYRDLKPENILLTQEGHIVLTDFGLSKWLTNETDQSTQTFCGTAEYLAPELLLGDAYSFGIDYWSYGTIIYEMLTGITPFWADNHSEMYRRILEEPLEFPTDIEYDTAEFLAALLDRNPATRLGCSLEHGGVDEIKTHPYFASLSWDDVYHRRLTPPYSPNLTSKLDFANFDPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163E574</accession>
    <name>A0A163E574_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_63074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294760.1">
        <property type="nucleotide sequence ID" value="XM_018441067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163E574"/>
    <dbReference type="GeneID" id="29001973"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63074"/>
    <dbReference type="InParanoid" id="A0A163E574"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15323" checksum="0C2990A02AE96A56" modified="2016-07-06" version="1">MSRTKRPSLILQGKMPVNAEYYKKFSSNCEAILLNISLFIGLTHIVFLSLFHLMFPESDSTKWDQIKLSHAGKKITICGPVESKSRPPKISIQTVQTVRYTTMCIYMLRKVKKDRLLSKKIDCNQQDRNNDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EJR6</accession>
    <name>A0A163EJR6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RuvB-like helicase</fullName>
            <ecNumber evidence="15">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHYBLDRAFT_131008</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="15"/>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297020.1">
        <property type="nucleotide sequence ID" value="XM_018429397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EJR6"/>
    <dbReference type="FunCoup" id="A0A163EJR6">
        <property type="interactions" value="787"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163EJR6"/>
    <dbReference type="GeneID" id="28990303"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_131008"/>
    <dbReference type="InParanoid" id="A0A163EJR6"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002221">
        <property type="entry name" value="RuvB-like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000002">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 15" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="68"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAD78980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="465" mass="51706" checksum="DEAA141AB2368CD2" modified="2016-07-06" version="1">MAMPITVSSSETKDLLRMERVGTHSHIRGLGLDDKYEPRASSQGMVGQLKARKAAGITLAMIKAGKTPGRAILIAGPPSTGKTAIAMAMAQELGTDVPFTSLAASEIFSLEMSKTEALTQAFRRSIGVRIKEESELIEGEVVEIQIDRSLTGGSKTGKLTLKTTDMETIYDLGTKMIESLDKEKVMAGDVITIDKASGRITKLGRSFTRARDYDAMGSDTKFVQCPEGELQKRKEVVHTVSLHEIDVINSRTQGFLALFSGDTGEIKQEVRDQINSKVAEWREEGKADIVPGVLFIDEVHMLDIECFSFLNRALEDDMAPIVIMASNRGVTNIRGTKYKAPHGIPADLRDRLTTISTSAYEEKDIRQILNIRCVEEDVEMSDDAKDVLTRIGVETSLRYSIHLITAANLVSRKRKATIVDVQDIKRVYSLFLDEKRSVQYMKDYEDQYMYNDQSEKVVEGTPMEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EKN1</accession>
    <name>A0A163EKN1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_162211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297170.1">
        <property type="nucleotide sequence ID" value="XM_018434585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EKN1"/>
    <dbReference type="GeneID" id="28995491"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162211"/>
    <dbReference type="InParanoid" id="A0A163EKN1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="115" mass="13313" checksum="25F305364F8AD583" modified="2016-07-06" version="1">MTDQSRQRWSMQREASPEVEDDDPMMEDDDEDENNEFESTAPFNYVPNSSANETDHKGYYADFGNQGPNIYQDSSLAWNDLSTKLDPLNFTMSKGLNKDFFHDFGDDFDDEEDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EP88</accession>
    <name>A0A163EP88_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Helix-loop-helix DNA-binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_161219</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298620.1">
        <property type="nucleotide sequence ID" value="XM_018434364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EP88"/>
    <dbReference type="STRING" id="763407.A0A163EP88"/>
    <dbReference type="GeneID" id="28995270"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161219"/>
    <dbReference type="InParanoid" id="A0A163EP88"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="199"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="154"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="247"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD80580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="427" mass="48296" checksum="0C15A736F570F57B" modified="2016-07-06" version="1">MPPNKTMIDSWDNVPLYYPHQQATITQQKETTQNVWPNCEIDKTLQDRPFVAYLDQFSLPSFEPLSMRETRVTSISSLRHGLCRTPSPQTTRSHDLNPTNTTNMNSPNTIPDHNDITIPVYLYKSNSIVVPHQISTNAVRKSSLFMPQLSSTLTNTTHTTNPPLSVPIPNSPVSSVSSQSSQSSLSSNQTSKNHTLARSKRDNHILSEQRRRNMIRTGFKEMTDLIPTLKNISQSKSIILFKAADYMKDLERRNKHLRDKLSALQWRAKLKAGQIKHHPVKSSPLVPLPHRDHLKQVRILEDQIRQQQRLLTQHNLPTPTPTPTIMQSNHDHNLVNTFSSTATHSQQQQQQQPSSHVHTTAHNTQAILVPMSKEDNSFIQWHSSSSASSSASSLAVPSLSIPADEDFGLESAQRDRWLSCGKMNQFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ERH8</accession>
    <name>A0A163ERH8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHYBLDRAFT_37284</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299100.1">
        <property type="nucleotide sequence ID" value="XM_018440089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ERH8"/>
    <dbReference type="STRING" id="763407.A0A163ERH8"/>
    <dbReference type="GeneID" id="29000995"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_37284"/>
    <dbReference type="InParanoid" id="A0A163ERH8"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000800">
        <property type="entry name" value="ATP-binding cassette sub-family D member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF69">
        <property type="entry name" value="PEROXISOMAL LONG-CHAIN FATTY ACID IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="116"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="453"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="676"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAD81060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="708" mass="81242" checksum="BA2595728895BAD4" modified="2016-07-06" version="1">MPNVFSKLATSPWRQALKQFLKQFLASYTNHRTTIRRSIILFFFLRSALNVHRTIQKFKKEQKKPRKIQSLDEEAMKKRRVDVDVHFLRQLHRVLKIVMPGVRSKEFWMLVVHSGFLVFRTILSVYIASLDGRIVSALVRGQMREFMLGIVWWMTVAIPATYTNSMLTYMQSKLSIQFRTRLTRHIHDDYLSDMTFYAVGNLDDRIKNADQCITVDTNKFSQSLSELYSNLAKPILDVFIYNYQLTRNVGFEGVFVASFIVQLSSIVMRKYTPSFGKMVAEEQRLEGEFRFRHSRVIENAEEIALFEGQKIEKNVLDTGYYALIKHVNRVFRLRIPHGMLEDFIVKYFWGACGLALCSVPVFFKVPGVDLGNVGSRTEGFVTNRRLLMSSSDAVGRIMYAYKEITELAGYTSRVVDLLDVFEDVKAGQFQKRLVSSASTDSNAKSLSGRGSVVESQNIEFVEVPIVSPNGDVLIPKLSFHVKPGMHLLIVGPNGCGKSSMFRILGGLWPVYGGTVHKPSHKDIFYIPQRPYLSLGTLRDQILYPHTVEEMHARNITDDMLLAILDVVQIKHIVEREGGWDSEKEWALALSGGDKQRIAMARLFYHAPRYAILDECTSAVSMDIEKIMYTHATDLGISLLTVSHRPSLWKYHNYILQYDGQGGYVFTKLDAEKRLALQEEKNAIEQKLLEVPKLEARLEELREIQQEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167J6G2</accession>
    <name>A0A167J6G2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_189596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441011">
        <property type="protein sequence ID" value="OAD65277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283317.1">
        <property type="nucleotide sequence ID" value="XM_018439682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167J6G2"/>
    <dbReference type="GeneID" id="29000588"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_189596"/>
    <dbReference type="InParanoid" id="A0A167J6G2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="308" mass="35504" checksum="1FEA47FB8A45952B" modified="2016-07-06" version="1">MFYQSQPEQRSNKQPDYKQEYDTRAANVLSGDQTSPNFQGKLILLEKGRVRWVITAALPRFDSNKIAHVLTLKVVLLYVVLKRFLTDNGTDFVSEAMRIGTTVIQEQLYPIEKKGLSPTYNLNAAIPPLVPRPRPSMIAIDVRPTLNTKPSNRKRQLGLDMFTIQKVTHLSEASPKFSPNYITLLQHLFRHTSSILTRHCTVIYPTPDIQLSDEFVMVDRRYTVREQAIPTFHRSDTRYTIDYSFGHVSFRPRLANTGIMHLSPCCTCRSFLTVDLAIQDHAPSYGTWRFNYFLSLKFRISTSSTYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JAM4</accession>
    <name>A0A167JAM4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_189553</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="KV441009">
        <property type="protein sequence ID" value="OAD65609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283649.1">
        <property type="nucleotide sequence ID" value="XM_018439677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JAM4"/>
    <dbReference type="STRING" id="763407.A0A167JAM4"/>
    <dbReference type="GeneID" id="29000583"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_189553"/>
    <dbReference type="InParanoid" id="A0A167JAM4"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="5">
        <location>
            <begin position="35"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="185"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD65609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="282" mass="31773" checksum="2836A5CD9A8E738A" modified="2016-07-06" version="1">MATTSTQTSPVSLTPDNNVTKRIIRSGQGQCPKADSIVSVHYESFLEDGSLFDSSRQRNAAYEFVPNGGKVIKAWEIAIPIMHVGELAEIVCTYDYGYGKKGWPPIVPQKANLRFEVELLGTWESAESVKQKISVALAKKEEGNAFYKQGAIEQALFAYRKGREYVVDVWDCEPEDLIKAREVTIALHANVAACYMKMRDWDKAIEVCQKVLDREPRNIKACYRIGQAYYEKDDYENGIGFVTIGLRGNPDSQELKALLAALEAKRDQWIKTSKELCKKMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JC21</accession>
    <name>A0A167JC21_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor SYF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pre-mRNA-splicing factor syf1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHYBLDRAFT_178496</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441008">
        <property type="protein sequence ID" value="OAD65679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283719.1">
        <property type="nucleotide sequence ID" value="XM_018437996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JC21"/>
    <dbReference type="FunCoup" id="A0A167JC21">
        <property type="interactions" value="802"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167JC21"/>
    <dbReference type="GeneID" id="28998902"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_178496"/>
    <dbReference type="InParanoid" id="A0A167JC21"/>
    <dbReference type="OrthoDB" id="10067343at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000023">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000137">
        <property type="entry name" value="Pre-mRNA-splicing factor syf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000182">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000038">
        <property type="entry name" value="Putative pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="12" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="15">
        <location>
            <begin position="14"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor SYF1 central HAT repeats" evidence="13">
        <location>
            <begin position="174"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="14">
        <location>
            <begin position="385"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="393"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAD65679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="742" mass="87407" checksum="E94458FC2F42A0F6" modified="2016-07-06" version="1">MATLSDDYMINEHDIPYEEELLRNPYSLRSWLRYVDHKRNGTLAELCFIYERAIKELPGSYKLWKQYLDLRRLKLSGMSPARFKAQYASVNSCYERALVLLNKMPRIWLDYLSFLTTQPFLTSTRRTFDRALRALPVTQHSRIWDLYLTFAEAAGGETAIRVLRRYLKLEPSHIETYVDMLIKLERFDEAAVKLVSVVNDNRFVSIRGKSQYQIWQDLCELVVEHCSDIKNLQVEPIIRSGIKRFTDQVGMLYCRLAMYWIKMGQLEKARDIFEEGVTGVATVRDFTAIFDAYAEFEEEMITTKMEMAAEREESGGKDEDEDLDLDLRLLRFERLMDRRPFLVNDVLLRQNPNNVMEWEKRVALWGDNRSKVVETYTQAVQTIHPKKSHGKLHELWVHFARFYEDGGDLDSARSIFDRAVKVNFKTVNDLAEVWCEYAEMETRHDDFDRALDVMGRATSVPKIPGVHPKQINFHDESLPVQQRVFKSLKLWSFYIDLEESVGTLESTKDVYDKVMDLRIANPQVIVNFATFLEEHEYFEESFKVYERGIELFGWPIAFELWNIYLQRFLKRYGGEKIERARDLFEQALDKCPPKYAKPIFLMFGKFEEENGLARHAMRIYERATKSVADEDRLEMFEFYAAKAVESFGVVSAREIYESAIESLPDKDVRIVCLKYADLERKLGEIDRARAIYGYASQFFDPRVQPEFWQTWHDFEVKHGNEDTFKEMLRIKRSVQAQFPSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JDC6</accession>
    <name>A0A167JDC6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_175941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441008">
        <property type="protein sequence ID" value="OAD65768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283808.1">
        <property type="nucleotide sequence ID" value="XM_018437605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JDC6"/>
    <dbReference type="GeneID" id="28998511"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175941"/>
    <dbReference type="InParanoid" id="A0A167JDC6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007888862" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="13248" checksum="A5C19A98B8DEE23D" modified="2016-07-06" version="1">MSRLFFQVILVCLLLQTRVYNISKQTYSPRKYQGFHFQLKKCKTKKCTEYMKPISCVAAGQIEQHEIATKVSPLAAGPSGAEAPGMTVESLTQVHWKNRPCRRVNSCRKLKPNDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JQ48</accession>
    <name>A0A167JQ48_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_70936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441003">
        <property type="protein sequence ID" value="OAD66477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284517.1">
        <property type="nucleotide sequence ID" value="XM_018442364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JQ48"/>
    <dbReference type="GeneID" id="29003270"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70936"/>
    <dbReference type="InParanoid" id="A0A167JQ48"/>
    <dbReference type="OrthoDB" id="2270683at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="509" mass="59106" checksum="2B5C2527BD79B1E8" modified="2016-07-06" version="1">MTISNDLQLKEETRTGPLQCILSRMLVGLVDECGNRLMVEEELAFFRLAFGDLNVLTNQHNQIYFKHPAFIGKSVLNLAVSNFLSAEYQWIDQEKMEQMYTLIFSNDKLYEMIEIFFEFDKYRSMLLLAYFMNIMSTHSVVEQWITSLLKLFCPVIFKLLPRALYNRLFGLENEENDVSIFKKPETTEKFLNYVVRGKGDIRAINIETVLPAPLSGWSVEIKYKLSPKAEWYIHSRHSPSKRKARELAIIDIVSYYYKNPEMIHSHHLPSLNSRESPENVLLIPYEDYYDIELSLKSLMILKPVVKKEDILEGAGYKRRIMFLDADDDDNDLMVALLGDLLAKDIAEKLSVEESLSKNDSHNPNKEPSISQNLYPRSTDYIDPCYLTKPPDSSIRDIKHDISTFSVYKQEDLDSVKAAIAQRPRLKRALNDNTRQRQPKDYIERIKYILGADITITLESFGPQHSLLFKATCLFRLSKFEIVTKAVLSKKSEAEMQAYRNLIDLLKEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JSM7</accession>
    <name>A0A167JSM7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_71951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441001">
        <property type="protein sequence ID" value="OAD66620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284660.1">
        <property type="nucleotide sequence ID" value="XM_018442569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JSM7"/>
    <dbReference type="GeneID" id="29003475"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71951"/>
    <dbReference type="InParanoid" id="A0A167JSM7"/>
    <dbReference type="OrthoDB" id="2243238at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="622" mass="73205" checksum="6FAA9289D4CD43BF" modified="2016-07-06" version="1">MTSFYIKGLECLDIKMAEKLSPNLISYIATFIPKADQISCSIVCKKWTQPLLNVIWSKIILSQRDIDNICNKYGQANNYWKNSHRVWALTLTNLPSNRAIFLPILQQMFRRLSYLEYTEVYQDKRWIVDSLNWNLWNSLTYLNVTLEYVDKSLVLMEMFEKLSVLRRLSNITIEDARNTAKNTTVSWLDIESLHQYLPRLKYLKVGLILTPITDADVELLHCIPPAYTLTRAEYSTRYMDDIWVLYLSLKYPSLQTLRLAPYYTDCTTPTTTESIRLYEKEKPISSIHTFLTLNKFFPNLTRADLCWKSPNGWKSSVFYDVFSKFGTSLVHLNVYLHESLDIQLLNSTIDKSRISKGLKIMTLFVYKSSFSKCGNLAFTISLYPYLAELNINAIHTPIEINNILVHCPVLQKLGIENSSVYLDNLSTHTYPHCLKKLNLAHLEVSTQVLNYISICCRGLKTLKMSFLKFSDSSFEENGQLLVDMPFTQLDTLTVREILFDKHPIHHFAIEQLKGLTSSLTTNHKELTQHISMGEELKFSWYHLCQDKTNRKLRSIAWGLSRRDIEFAKRYYRDFGRRRRREKKRKDMRRSNGLVLRRFWKRDLQYGMILFRFRFIKDYYITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K4F4</accession>
    <name>A0A167K4F4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_63746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285298.1">
        <property type="nucleotide sequence ID" value="XM_018441169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K4F4"/>
    <dbReference type="GeneID" id="29002075"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63746"/>
    <dbReference type="InParanoid" id="A0A167K4F4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007889164" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13501" checksum="177C7EF0DB056FC9" modified="2016-07-06" version="1">MCLNVLLKVIRCAALLRAQMAGERMACELNFAQIFAVFQLFFAHYKNSQIMLIISLDSLPASLSLHTIICFSIYYVSEPQWNLGSFSSQAIILLPENANKTMLKTCPNLDPDFFWCDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KCD8</accession>
    <name>A0A167KCD8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_151274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285787.1">
        <property type="nucleotide sequence ID" value="XM_018432646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KCD8"/>
    <dbReference type="GeneID" id="28993552"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151274"/>
    <dbReference type="InParanoid" id="A0A167KCD8"/>
    <dbReference type="OrthoDB" id="3247418at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="312" mass="35387" checksum="754E3A47066DBB35" modified="2016-07-06" version="1">MPSIFMAHLDEAHQSLEAFCRKCKKLYKAPFLLPNMHLHLHLFERCNGILKNYATNRKHGFEEIYMKKYLEEAYQGDFIHQTLPIIRPEHSAIILELTASTANSIATSTSTAISIQFDINAFLDSPEINFDIFKRNEPLPPSALPLALKGEISMDESEYEHLLEYYCKTYNDQTLVHYCQAGHSNNFVTNLIQKFESIDLFGQIYKSKMKNQHGSFMQALFETSDGRSIKSYAGQIQYFFVNTAANSFAGYASQHEVLLQPRAGEGVEVNEVGFEDDSMNSILPVHRICYPVAAGDHLGLESKVQMCVVPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KR42</accession>
    <name>A0A167KR42_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor 3B subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pre-mRNA-splicing factor SF3b 155 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Spliceosome-associated protein 155</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_127497</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286719.1">
        <property type="nucleotide sequence ID" value="XM_018429168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KR42"/>
    <dbReference type="FunCoup" id="A0A167KR42">
        <property type="interactions" value="878"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167KR42"/>
    <dbReference type="GeneID" id="28990074"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_127497"/>
    <dbReference type="InParanoid" id="A0A167KR42"/>
    <dbReference type="OrthoDB" id="438939at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000303">
        <property type="entry name" value="splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000810">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000088">
        <property type="entry name" value="Splicing factor 3b, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015016">
        <property type="entry name" value="SF3b_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08920">
        <property type="entry name" value="SF3b1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Splicing factor 3B subunit 1" evidence="12">
        <location>
            <begin position="216"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="13">
        <location>
            <begin position="991"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="113"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="172"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD68679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1209" mass="136501" checksum="2C56A790FF08B281" modified="2016-07-06" version="1">MADDIENEIKATQAKRAQITDKDISAAVLNNEKHASLSGVSYDKDLYITDKYEGYSTSIAIDDEDADADEMYQETKRKLNSYTVSKDLINDTIGDTEGRDPFADTMNNRTIAGRQDEYQQRRFNRMLSPSRKDAFAADQGTDDQESRSYSEVIREAELEKEQQRVYAAIAQKEKEREQQIKQGVADDSQQAKKKRRWDVATPLHDNNADATPVGGANKRSRWDATPVSGERSEWDATPKASSGKRSRWDATPVGGDVMGATPVGGMGMMTPTPSKLQVPMTPEAANSMRWERELDVRNRPLSDEELDSMFPTTGYKILDPPHGYVPIRTPARKLMATPTPMGDSGFMMQDDVRQPVMELPQEIPGVGSLPFFKDEDMQHFGKLLEQRDETAMSVEDLKERKIMRLLLRIKNGTPPMRKTALRQITDKARDFGPGPLFNQILPLLMSPTLEDQERHLLVKVIDRILYKLDDLVRPFVHKILVVIEPLLIDEDYYARVEGREIISNLSKAAGLPTMITTMRPDIDHPDEYVRNTTARAFSVVASALGIPALLPFLKAVCRSKKSWQARHTGIKIVQQIAILLGCAVLPHLKNLVEAIGHGLEDEQQKVRTITALAIAALAEAAAPYGIESFDSVLKPLWTGIRKHRGKGLAAFLKAIGYIIPLMDDEYANYYTKEVMLILIREFQSPDEEMKKIVLKVVKQCAATDGVQPQYIKEEILPEFFKHFWVRRMALDRRNYKQVVETTVELANKVGVSEIVGRIVEDLKDESEPYRKMVMETIEKVVSNLGAADINPRLEELLIDGILYAFQEQTVEDVIMLNGFGTVVNALGMRIKPYLQQICYTILWRLNNKSAKVRQQAADLISRIAVVMKTCGEEKLMSQLGQILYEYLGEEYPEVLGSILGALKSIVNVIGMASMTPPIKDLLPRLTPILRNRHEKVQENCIDLVGRIADRGAEYVSAREWMRVCFELLDLLKAHKKGIRRASVNTFGYIAKAIGPQDVLATLLNNLKVQERQNRVCTTVAIAIVAETCAPFTVLPAVMNEYRVPELNVQNGVLKSLSFIFEYVGEMGKDYINAVTPLLEDALMDRDLVHRQTACATIKHMSLGVVGLGCEEPLRHLLNFIWPNIFETSPHVINAVMESIEGMRVALGPATILQYTLQGLFHPARKVREVYWKIYNTLYIGSQDALVPYYPRIDDDENNNYQRCELDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KX43</accession>
    <name>A0A167KX43_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EBNA1-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_22175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD69087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287127.1">
        <property type="nucleotide sequence ID" value="XM_018439778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KX43"/>
    <dbReference type="FunCoup" id="A0A167KX43">
        <property type="interactions" value="534"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167KX43"/>
    <dbReference type="GeneID" id="29000684"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_22175"/>
    <dbReference type="InParanoid" id="A0A167KX43"/>
    <dbReference type="OrthoDB" id="443772at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD69087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="25387" checksum="CF853584344E2C65" modified="2016-07-06" version="1" fragment="single">DLPWIETMVVTSSEPTVVADVEDEMARELSFYQQALEAANIARDLVNQAGDAFTRPDDYFAEMLKSDEHMAKVRQRLLDETARLKASADAKRQRNLKKFGKKVQVEKQLERQKQKTDMLDKIKLLKRKRKDGAGGDLTLDNDFDIALENTTDKKRAKTDSSQKGSKKDAPQKGAKRAHKDTKYGMGGKKRHAKSNTAESSGALGGFNKMKGKPIYKAKGKTVGKAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L2W0</accession>
    <name>A0A167L2W0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_188256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287506.1">
        <property type="nucleotide sequence ID" value="XM_018439472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L2W0"/>
    <dbReference type="GeneID" id="29000378"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_188256"/>
    <dbReference type="InParanoid" id="A0A167L2W0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="116" mass="13676" checksum="36178B8A238E2A1A" modified="2016-07-06" version="1">MYMQLANYGEIQFSLVVGMSLSTFKGTNGFAYDCTRVYKIYWTPSVVLNELQGLVLKREILNTVHILINVNNADDNRVGVVWQNTHFYICRIRVAQFRVLYFSRFAFYFEIATEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L641</accession>
    <name>A0A167L641_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_149462</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287719.1">
        <property type="nucleotide sequence ID" value="XM_018432279.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A167L641">
        <property type="interactions" value="118"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167L641"/>
    <dbReference type="GeneID" id="28993185"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149462"/>
    <dbReference type="InParanoid" id="A0A167L641"/>
    <dbReference type="OrthoDB" id="1893551at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="183"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="249"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="300"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="965"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="478"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="687"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1218"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1317"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="712"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="735"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1249"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1317"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1335"/>
            <end position="1347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD69679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1532" mass="169361" checksum="7A9C4DC6488E6589" modified="2016-07-06" version="1">MPSVSIFKAIKDNNIDLVKFLIGLGTKSNQSANVTKEDQQWLRNHLKTTGQKQYNLNKRSSKGKTALHYAVQWNRISIAQCLIECPMVNINLQDLESGWTALHRQDWEGLSPFELYNLTVKDSSYPNISTLKVETPASKLTQLDDLLNLNSHYQLQHQYQYQYQQQNQNQNQNQNQHVVAGGTDLYTWGINTNYVLGLPDSDNKSRPERVRLDLESQRIPEITSRPPYLVRTVVMSKYHTAILTSEPRNNLLLCGFGRGGRLGTGKVVDTQLTPIAVQWPEYIVAVALGRDHTIALSKSGNVITFGNNRFGQLGYETDAGKDETPMQLVPRKIQAANLKRLPIIGVAASSVHSVVYTSSDIYTFGYNQGQLGYTYLGDDICQTTPKKVTFSEKIIQVVVTDNATAVLFSTNQAVLLFNYGQQKLILPWKRFPSKMQVHKPARNLISKLITSGGGDYMGAISNMGEVFIWTCKSNAATTRRQNEGSGTGTGTGTGTGTGTSAGIGTGTGTSTTGSGTNAGTGTGIDTSASTGTGTGTGIDFGARSRSTIITTMSSPRIVWAPRLAHLEARQASIGQNGQVIVCTAMGEVYIGAPSGPNENGEYRFNKIPFLQRCIYVSANPSGAFAAIRAEYKASKQQAIIPHVSDHLVSALPHKAVAKMLDEQIKKFDAQKQSALEELRNNQLAGEYGHDKNIKNNHSHNHNHSNTNTNTKTKTKIKINNNHNKHNKNNKNNNINEDEDEDEDEVKEMKQKIHTRYNFQIETAVSDAWKSVENLSRDDATLDLVFVVQNRRIYLHKFFLSSRLRFLIGGGSSNNRSGGGDDTYSGDLVEPKIPHSSSIFHQLLAVINNPERSEIHLATTHLESFLLLVDYLYSDNYAHPMSTLYKSPLLCRASDIPTATAAAAGTATAAPFLVVRPLDVQKGLINLAEELDLAILLDSAQSTFNHTPQSSLLTDLELLLTNKVTQDVQLNLKDGEVLFCHELIVRQRCPFFEALFCPGSVWMEERREANRTNAAVDGNNGTPAGNKQSYLPVDLGHVPVEVMASVLEYLYTGHNEVELFGKVAKNTVEEMVEFLMEVLCVADELLLPDLKALCERSLIDFISLRTAVVLLERADACLANLLKQECLGFIGANLSTFITCGMLEYTDNRLVGYLEEHVQSWQAQERKFSGIQRDLAQVDSKDREMDDPEFSTSLYALSLEDMPIISSQRDILVTVYPKKPAVPDHNEPSRASLAIKDKKPKAAHVSSQKKGGESRKRGVRLDLGATENEIEAIARSLTKTSHSLTSRQGWATPVVGIQAESLKPSLREILEQEPQAIDLSSSGHSPPTQAKLVQPHLKKVSQKERRRLQQQQQEMAGSGSGSGLKTGVWGKITTEKPELIKATVPNNVPGLSLNPAINLAQKYVPEELVNAETSAIRRPVENDIKIGSNSDKVVSDTFEAGGLVDGFVLTPIRRRNAYGDLMALCSDDVAETGSFEKILRQQALDKMRKDRRPKKSLVRIQTEERAVEGLREFYVQTIEVESGEWFEVNRVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LB06</accession>
    <name>A0A167LB06_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_172040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD70025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288065.1">
        <property type="nucleotide sequence ID" value="XM_018436719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LB06"/>
    <dbReference type="GeneID" id="28997625"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172040"/>
    <dbReference type="InParanoid" id="A0A167LB06"/>
    <dbReference type="OrthoDB" id="2275136at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="156" mass="18180" checksum="D1323F82F3205ADC" modified="2016-07-06" version="1">MASVSATRPNRTHHRLLPLRSWLKANVATPPQPMRHSIVTLASYMTVGTIAIVAISSLFCLFMAVSMVDDVLRITAPDRLWLLLRDHWLRLDWTHLADKLSEQLTSLAEWERQKRAAWYPYDHPSYHDGDRFHDLLFAATHYLNEYVQINTKKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LN70</accession>
    <name>A0A167LN70_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_64143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288818.1">
        <property type="nucleotide sequence ID" value="XM_018441243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LN70"/>
    <dbReference type="GeneID" id="29002149"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64143"/>
    <dbReference type="InParanoid" id="A0A167LN70"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="123" mass="13926" checksum="125617ED3834677A" modified="2016-07-06" version="1">MNKPILLCVFDYEETTLIKNKLQVSTPYDLVSGNRNKNPKGLMRGRLWESISVKIQQNVAHTSLRKPKKSVKTLTMPVYNWIGGRAGRSVCLMQCKGRSELGQVIALQRNKSVILANGTRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LN80</accession>
    <name>A0A167LN80_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_64142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288819.1">
        <property type="nucleotide sequence ID" value="XM_018441242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LN80"/>
    <dbReference type="GeneID" id="29002148"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64142"/>
    <dbReference type="InParanoid" id="A0A167LN80"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="151" mass="17077" checksum="CAC6EDEDF377D81A" modified="2016-07-06" version="1">MKPRFYFMGIKRPCLHKSLSAHSCSKVIPVGIDINYGQSSINCFETFGRYKILLERKRDVSANDLYLKQVHELLLSRYEESGSLNKMFPSFEKNLKTLKTWKILDALRVMRGIRGIRVIRAIRVIGALMTLRALGALGALGASKSSKISQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LSX8</accession>
    <name>A0A167LSX8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_80381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD71028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289068.1">
        <property type="nucleotide sequence ID" value="XM_018443579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LSX8"/>
    <dbReference type="STRING" id="763407.A0A167LSX8"/>
    <dbReference type="GeneID" id="29004484"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_80381"/>
    <dbReference type="InParanoid" id="A0A167LSX8"/>
    <dbReference type="OrthoDB" id="2289277at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="389"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD71028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="462" mass="53362" checksum="627AF40275B768EE" modified="2016-07-06" version="1">MTKHNKLASDNDEIRVVKLRSTVDNRINLEYLTVLVATFFNGGRVTVVYDWKCPNHNHLKLSGISRFRLSEEARIWTNKYTENFFDWKAIKGALRPEEMGNSTSVTSIPTTMVIQYKDVHNATVTRINNSARKHYKDETKNAEEWYLDSTHKTCMSFLDNKECYLMSVVVYNPVTNKGVPVAFSVTSIEFSSIIPNRAEIYPGFIWTFSSNSSVTLAYQACLGKSCQEVHSNNEANYNAHWQKFRLDYGMQFPVLMSYMEVIWEPKKKSWVKAWRQDAVCHTNNLIESYHNQLKSFYFGRSRNCRIDKIIYVLSQLAERDYRQNTLEIYFDIKSIRLSVANTERKKKADVIAIERANGLVGEFEPQELQAYKMYSCKSFGEDSELVHFIKFTTHLHNCSCPDSARLCKHIFLVSRVLDLPVTVRRNVILDSAALLDLIKKTHVGSLITSNAYFMVSSLSPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LYP3</accession>
    <name>A0A167LYP3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">holo-[acyl-carrier-protein] synthase</fullName>
            <ecNumber evidence="1">2.7.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_147854</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.8.7" evidence="1"/>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289404.1">
        <property type="nucleotide sequence ID" value="XM_018431965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LYP3"/>
    <dbReference type="FunCoup" id="A0A167LYP3">
        <property type="interactions" value="414"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167LYP3"/>
    <dbReference type="GeneID" id="28992871"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_147854"/>
    <dbReference type="InParanoid" id="A0A167LYP3"/>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055066">
        <property type="entry name" value="AASDHPPT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050559">
        <property type="entry name" value="P-Pant_transferase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215:SF10">
        <property type="entry name" value="L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215">
        <property type="entry name" value="PHOSPHOPANTETHEINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22624">
        <property type="entry name" value="AASDHPPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase N-terminal" evidence="4">
        <location>
            <begin position="22"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="3">
        <location>
            <begin position="115"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD71364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="268" mass="31190" checksum="46769F851FC23B2E" modified="2016-07-06" version="1">MSTLPPLSLLALNVKNLFDDGRFKEALEWLPISEHAHVNRFRFDADKHRALGSLLLRRYFFSKFLGVPWKELCFDRRPGSKPTLKIGNDTWVDYNTSHEGEWVVFVATSRPGLVVGIDCVRIDIPLHTDIPQFLRSFQSQLSTEEIEWIFYTNEENNMLKRFYELWGCKESYVKAIGVGLQRDLDTLSFKNKTEKEAWIVMQEDNWGYHLSDLDNDTIVVVCSGYPDKRPLDHDILAFCATTRPLGATYHQQAPFELVRWEALSNYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M658</accession>
    <name>A0A167M658_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle subunit SRP14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Signal recognition particle 14 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_169830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of a fungal signal recognition particle (SRP) complex that consists of a 7SL RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SRP14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD71917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289957.1">
        <property type="nucleotide sequence ID" value="XM_018436169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M658"/>
    <dbReference type="STRING" id="763407.A0A167M658"/>
    <dbReference type="GeneID" id="28997075"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169830"/>
    <dbReference type="InParanoid" id="A0A167M658"/>
    <dbReference type="OrthoDB" id="19209at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003210">
        <property type="entry name" value="Signal_recog_particle_SRP14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12013">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02290">
        <property type="entry name" value="SRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD71917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="123" mass="13948" checksum="EFDC198512076D62" modified="2016-07-06" version="1">MRDLDPIAFTVELGKFYELSKESGTVAVTMKRMTPERLAITLKVKKQLPKGGQDAMKKTDDASTLRYPCLVRATYKTKKISTTVSVDEFDRFQSAYSTVIRAYMDTLKKKERVKKAKKAKTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M9I4</accession>
    <name>A0A167M9I4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NCS2</name>
        <name evidence="3" type="synonym">CTU2</name>
        <name evidence="4" type="ORF">PHYBLDRAFT_71211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290237.1">
        <property type="nucleotide sequence ID" value="XM_018442428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M9I4"/>
    <dbReference type="FunCoup" id="A0A167M9I4">
        <property type="interactions" value="275"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167M9I4"/>
    <dbReference type="GeneID" id="29003334"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71211"/>
    <dbReference type="InParanoid" id="A0A167M9I4"/>
    <dbReference type="OrthoDB" id="25129at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD72197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="457" mass="51603" checksum="B273BB31D72B96E2" modified="2016-07-06" version="1">MKPTKIPCCKCKTELATVLIRHAYYCKVCFTFVFVGKYRSIITKSRSISRNKGKVLLACSGGPSSLAMLNLTHEFRRVEPHEKKKVQILGPTVICHLDESTIFEEQKDTLGKLQKLMKEKYPDVPFVSNRLEDVFSDEFSDNHHIDKSLKSVTEFGNIGYEHYVQLIQETPDKTSPADRLKHLFANINKNTSKEDLHWHIKFAMLVSIARREGCSYIFMADSSTRQAIKMISMTSKGRGYSIPMDVGAENNASFKDLVIMRPMKDMLAKEIALYNRYYGLDAHVIAPTQWGTRMAAKTSIDRLTEEFITTLDRDFPSTVSTVSRTASKLTPSSDVDLSRRCAICLMPHQSKINEWRKRITVTTPQGGSLEPDVTKSCGTTEEGGCCGGGSGGGCDSSKSGIDMNEYLCYSCQVDLKDYKEAAIESLPPYVTHIIDEKERQERLREQIEEFLLSDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MBJ5</accession>
    <name>A0A167MBJ5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor SLU7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_134264</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLU7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290414.1">
        <property type="nucleotide sequence ID" value="XM_018429637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MBJ5"/>
    <dbReference type="FunCoup" id="A0A167MBJ5">
        <property type="interactions" value="677"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167MBJ5"/>
    <dbReference type="GeneID" id="28990543"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_134264"/>
    <dbReference type="InParanoid" id="A0A167MBJ5"/>
    <dbReference type="OrthoDB" id="249612at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030628">
        <property type="term" value="F:pre-mRNA 3'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021715">
        <property type="entry name" value="Slu7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039974">
        <property type="entry name" value="Splicing_factor_SLU7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942">
        <property type="entry name" value="STEP II SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11708">
        <property type="entry name" value="Slu7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor SLU7" evidence="9">
        <location>
            <begin position="143"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="174"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD72374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="442" mass="50199" checksum="D29D2F3B18DB99C3" modified="2016-07-06" version="1">MSGLQQPNRLTKEEYRKQKDLDAARKAGTAPAEVDDEGNEINPHTPQFMLKAPWYVDNGQVSLKHQRAPEKRPGTKFGAEDNFWYARGQRAGPAATKYRKGACENCGAASHKTRDCVERPRKKGAKWTGKNIKADEIVQEVDLDWDEKRDRWNGYDPKEHDKVIEEYNKIEEARRAAKATELDKEGPTTTSEAKKIAGMSDDEEEDDDDKYADQADMPGQYVNQKTRMTNRNLRIREDTAKYLLNLDTDSAYYDPKTRSMRDNPLREEQGADDVPFAGDNFVRYTGDAPAMAKIQLFAWQAADRGSDVHLQANPTQVAILHQEYESKKDEVRGSTQKSILEKYGGAEHLESVPKELLLAQNENYVEYSRTGRVIRGLEKAKTKSKYEEDVFINNHNSVWGSYWADGKWGYKCCRSYVRNSYCTGQAGIDAQKASQMASHGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MCF6</accession>
    <name>A0A167MCF6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_181835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290497.1">
        <property type="nucleotide sequence ID" value="XM_018438527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MCF6"/>
    <dbReference type="STRING" id="763407.A0A167MCF6"/>
    <dbReference type="GeneID" id="28999433"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_181835"/>
    <dbReference type="InParanoid" id="A0A167MCF6"/>
    <dbReference type="OrthoDB" id="431409at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010723">
        <property type="entry name" value="HemN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="COPROPORPHYRINIGEN III OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932:SF5">
        <property type="entry name" value="RADICAL S-ADENOSYL METHIONINE DOMAIN-CONTAINING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06969">
        <property type="entry name" value="HemN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="501" mass="56976" checksum="836C57479C406392" modified="2016-07-06" version="1">MRTLIKHNLHSFGIKTQSFSTLNTKLPAKTPFSIYIHWPYCESKCTYCNFNKYINPRDPPHERLVKAMTRELDFYLTDPRFGLKNKRLNSVYFGGGTPSLALSIESAKLQDFAKAGVNRLSLGIQSFNDKDLKVMGRDHSGTDAIRAITKAKQVFHKERLTFDLIFARPGQTLEAWDDELKQGLELAGDHMSIYQLTMERSTPLHKASVRGELPPLPSPDEAADMYEQTLKRTSEYGFSHYEVSNYCQNESAISRHNFSYWQGMDYLGVGPGAHGRLTRTEDGVRVRTFGEFHPNKYMALCESEGEGIRKMVPISARETIEELIVFGMRTRMGVPRARFQAMTGLYLDNVLDKEMLQTYIEAGFLIDEAGVMDQAMNKYVPNELLSEWDLHGGIRPTESGLERMDSIICSRFQKFKKSMFPGSSNITVCSYANLNWILTDSPSEFFFIGTLEISALNTWSTVTKRTLINRPAITLEFKQHVIAYIIPACIIPACVSQQMFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MDK7</accession>
    <name>A0A167MDK7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_65416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290584.1">
        <property type="nucleotide sequence ID" value="XM_018441455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MDK7"/>
    <dbReference type="STRING" id="763407.A0A167MDK7"/>
    <dbReference type="GeneID" id="29002361"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65416"/>
    <dbReference type="InParanoid" id="A0A167MDK7"/>
    <dbReference type="OrthoDB" id="2256373at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="121"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="346" mass="39585" checksum="D47BFFACE4F7A297" modified="2016-07-06" version="1">MDQIIHGIYVCTLFIEKRLSSECDDQPVAIALRKMDVKDTRRLPSSIRGHIKLYDIVSKPTEIKSVKKAGNYIWQFTHNFSLAGTSEPTLIIVKFEGETDQPFCLSPFLNFSNHTRFSEFSDMIVKIVKSENEDDTESGHETRIFRCHKIILATASSWFKNLLTNGSYDSKDWTVTIQGINPDIFKKVLDFIYSSNCDVNDVDEAFEIIKAARLIELDSLCEIMFGYLRPKIDFDTFWPIFSLAVDYDCIPTIMAGKEFVKTNAKEFYSCAFSFERDAADILKSQSQDTSSSDISNLASSVIQLGLDETKQKKDKDTLEKLTKNAHDLFEFTIACHTEMTYWKTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MHC4</accession>
    <name>A0A167MHC4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_78003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290886.1">
        <property type="nucleotide sequence ID" value="XM_018443323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MHC4"/>
    <dbReference type="GeneID" id="29004228"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_78003"/>
    <dbReference type="InParanoid" id="A0A167MHC4"/>
    <dbReference type="OrthoDB" id="10322828at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="207" mass="23164" checksum="88360D5EE6F810DA" modified="2016-07-06" version="1">MASNQNYYPTSGHGKDKNSDKSERHLFHIGDSDNDLHGNGKTAEEIQESETKEKPQHSNYGQGNDESRIPKFDDYRKYGEYGNTSHDAARATYIDPKVIPSAVGAGADSTGRAQKIADARGQQHNNGNHVISEGAEKSNKEAKATLHDKIKGRFESFLGRLTCNDERVAKENMLLNIELLILRSNVDFLRLSCKERVMFHTESKLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MVT5</accession>
    <name>A0A167MVT5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">General transcription factor TFIIB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHYBLDRAFT_181146</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Associates with TFIID-IIA (DA complex) to form TFIID-IIA-IIB (DAB-complex) which is then recognized by polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292234.1">
        <property type="nucleotide sequence ID" value="XM_018438424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MVT5"/>
    <dbReference type="FunCoup" id="A0A167MVT5">
        <property type="interactions" value="607"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167MVT5"/>
    <dbReference type="GeneID" id="28999330"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_181146"/>
    <dbReference type="InParanoid" id="A0A167MVT5"/>
    <dbReference type="OrthoDB" id="25790at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20551">
        <property type="entry name" value="CYCLIN_TFIIB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000008">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000141">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.170:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000036">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="15">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAD74194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="338" mass="37218" checksum="DDB511AEE2B8FE37" modified="2016-07-06" version="1">MTTAIPFPLREPHQVDAGSQPFHPNLSVKLICPDCRVDPPQIVEEFASGDLVCGECGLVLGDRIIDTRSEWRTFANDEGDDPSRVGAAANPLLDGNQLDTIISRIDGGTGAARDLNRVHGRATAVRGERNLVQIYKEISAMCDSISLSKLVSDTAKQLYKRVEDEKLLRGKSSDAIVAACIFIACRQENVGRTYREICALTRVTKKEIGRCYKALQSKLQTNTTIMNSEDLMSRFCSNLQLPNYVQKSGVDLVKRAKELGTLAGKSPISVAAACIYLVSYLFRQPKTARDIAHVAGVSEVTIKTAYKSLYAEKERLINLETLYSSQITDITFESLVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MZT8</accession>
    <name>A0A167MZT8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_61319</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292664.1">
        <property type="nucleotide sequence ID" value="XM_018440788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MZT8"/>
    <dbReference type="FunCoup" id="A0A167MZT8">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167MZT8"/>
    <dbReference type="GeneID" id="29001694"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61319"/>
    <dbReference type="InParanoid" id="A0A167MZT8"/>
    <dbReference type="OrthoDB" id="153074at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000281">
        <property type="entry name" value="Uncharacterized oxidoreductase YIR035C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF8">
        <property type="entry name" value="BENZIL REDUCTASE ((S)-BENZOIN FORMING) IRC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD74624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="256" mass="27461" checksum="5A6A0FB3F6D84F45" modified="2016-07-06" version="1">MSSPVIIITGASRGIGRSATFLALSKFNARVVAVARDESRLIALKLEAQAMGKADNLITVTGDVTNETTNSNAVDQALSTWGQLDAIIANAGVLEPVDTIANGSLEVFKHLFDVNFFSIIDLCQKALPHLRKTKGSIIMVSSGAALKGYRAWGAYGSSKAALNHLTNTLSVEEPDVTTIAIRPGVVDTEMQGLLRSIGKDTMEGDYQKFVDLYEAGKLIKPEQPAHVLAALAAKAPKELSGRFISWDEDILAEYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N491</accession>
    <name>A0A167N491_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_144291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292979.1">
        <property type="nucleotide sequence ID" value="XM_018431186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N491"/>
    <dbReference type="FunCoup" id="A0A167N491">
        <property type="interactions" value="590"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167N491"/>
    <dbReference type="GeneID" id="28992092"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144291"/>
    <dbReference type="InParanoid" id="A0A167N491"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000001">
        <property type="entry name" value="Oxysterol-binding OBPalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF102">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD74939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="47097" checksum="699819BA1A8B0470" modified="2016-07-06" version="1">MFRKTIVEDDSHDTEVLEENSRNIIVGIISQLRKDMDLSRVALPTFILEPRSMLEKITDFMAHPDILLEASKTIDPVDRFVEIVRYFMSGWHGVKKPYNPVLGEFFRCQWQFRDQTKAYYVAEQISHHPPISAYYFGSPDNGIHIEGEIHPKARFLGNSAASIMQGYSRIHFTRFSEEYHITSPNVYARGILCKYHVLMFGKMTMELGDRAIIRCEANDLVCEIDFKAKGVFSGQANLISGKIKRESTSQVLYELSGAWNSHIFIHKAKKPSSPISFFHVQTASKPVPKRVDPEEQQDLNESRRLWAKVTAAIKANDMDLARDEKQWIEDSQRVETTKRQKQSLVWQPRFFVATGTDYRFKGSMAIQPRQTQQDLESWIFGPLSSTSRSTQEILQERRPVQAELTVVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N6P8</accession>
    <name>A0A167N6P8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP synthase subunit K ATP19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ATP19</name>
        <name evidence="5" type="ORF">PHYBLDRAFT_181090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293194.1">
        <property type="nucleotide sequence ID" value="XM_018438415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N6P8"/>
    <dbReference type="STRING" id="763407.A0A167N6P8"/>
    <dbReference type="GeneID" id="28999321"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_181090"/>
    <dbReference type="InParanoid" id="A0A167N6P8"/>
    <dbReference type="OrthoDB" id="2094445at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021278">
        <property type="entry name" value="ATP19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11022">
        <property type="entry name" value="ATP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD75154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="70" mass="7378" checksum="D2DCF90C423EDBD9" modified="2016-07-06" version="1">MAGHYVIAGKKVPFHILSIGFISAYAIAGTAYAMKPKPAQPATPPIKASSSDEEAFIKQFLAEAEAGEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NA64</accession>
    <name>A0A167NA64_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_64378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293504.1">
        <property type="nucleotide sequence ID" value="XM_018441287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NA64"/>
    <dbReference type="GeneID" id="29002193"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64378"/>
    <dbReference type="InParanoid" id="A0A167NA64"/>
    <dbReference type="OrthoDB" id="2254641at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="315" mass="35225" checksum="1068845F87FE3758" modified="2016-07-06" version="1">MTDQPIDNQENNDEPNDESNAKRRRTTDVFDTLGSSIQGMQSSFSSITSLFTNSISNTLAINQAMNEMYEQMFMSNIKKGSKLKPFEDKNGSGIQLTITITNYNRYPISGLSAHLTFEPFHKADTAATVAWTSESASETTVGSRNKKDVERILGSNQGQDKDQNQDQNQNQNSIPSTTIYTEILQIQPSEPCQYNSKLSVSVSSPGTGKPIEKEHKFGLYLIDQLIKTVHESGSSSEETKGSEKEYSTVFFREIMGLRPVVGIRPGMEIRLKAKQKEVMCKVVESSENLETVKAIFYGDHQLLDILLQELDILDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NIH3</accession>
    <name>A0A167NIH3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_59530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294038.1">
        <property type="nucleotide sequence ID" value="XM_018440515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NIH3"/>
    <dbReference type="STRING" id="763407.A0A167NIH3"/>
    <dbReference type="GeneID" id="29001421"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_59530"/>
    <dbReference type="InParanoid" id="A0A167NIH3"/>
    <dbReference type="OrthoDB" id="2404451at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD75998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="858" mass="96765" checksum="B4D668FCA4339453" modified="2016-07-06" version="1">MSSSNASQQRDRISTQQYQCDQCVLFFDNYQKLQNHKRIHRGDSATMTEIDQSILDDVDMYHNENDTSNEDESVSNSEYTMESMELDNTISYKCACNFEDSEGEAHIYDSSQISTNTFTKAELMSIHLSQLMLQHRIARAAYRDIVQFINTVIRDHDDIMMEPGAKISHGETVDALLKSKSSVKGHEYDVCSSGCRLYGINDDQESCVNCSKPRYKTDPNQSQTPATSMKLMSVGDMLSQMLADPATRELLCYRANQESVAGQLTDIFDGDNYKQLVQQGLFSNPDDIAIELYTNGFVNQKKGKNSYTIIHCIIFNLDPSIRYTNKYLLQLAILPDPKKPTHLDSFLIPIINELRDLEAHGLVVKHNGVELCRFKVYLLLASGDIPAVADMAHIGSHTSLFGLPFLRHGMYFDDISARLRPLEDFKVGNPSKNIYQPSIYTQLSTFSGSSFFALDELHLIARGIGKLVYDLITITLTKETKFYYTHPDNTLNTTEYPFHIPRADLVTIGNCITSSRKYIPTSFQGSFDNVFAKIDGTHAVDWLDFLLYLVPTLVVPYLPNRAVKTALLSLMKGCALALQWTLTSELLDEMESTGTRFYTNKSRIIPCLVVFSDQCNITWSIYPISSSSKAPCDATPLAQWRDPNQRVAKTPVFSLSNLRFTIIPARQSASPYGRESYMDLPNDPSGAQLWEPFHQFVNLNDDSVEGVGGPSVKEALLKYYRRTTGLTGHEFGDSVVVVAARLNRNVIVHSWLVGTVQFYFQHVDFYGFPHFLAFVEVMKEHDTAGHDSSVPIVKQRSQSTCTLGHQTQPTYAVISVNDICHQVGLVQYPPNGNQFYVIAPYYIFNNNMRITKGNLSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NIV1</accession>
    <name>A0A167NIV1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_110302</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294069.1">
        <property type="nucleotide sequence ID" value="XM_018428160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NIV1"/>
    <dbReference type="STRING" id="763407.A0A167NIV1"/>
    <dbReference type="GeneID" id="28989066"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_110302"/>
    <dbReference type="InParanoid" id="A0A167NIV1"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF45">
        <property type="entry name" value="MITOCHONDRIAL CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="84"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="186"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD76029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="31189" checksum="302ADBD0C3B3AB9C" modified="2016-07-06" version="1" fragment="single">SFGGMANVLVGQPLDTIKVRLQLDNGRFKGAWDCTVQTIKNEGFLALYKGMASPLFGIGAVNALLFAANSSIKKNMQEYPGQVLSIGQIAIAGAGAGVVNSVLASPVELLKIKMQAQFGSKAIGKERYFSGPIDCAKYLVQQHGVANGLFRGMWATVLREIPAYAGFYAGFEATKRQLVKDQDEHANIMQLMAAGAVGGIGYWVCCYPLDVIKSVVQNQALPPTGFYVTRVMKQIVARDGISGLFRGIAPTILRSIPAAGATFTAYELTIRAFQSDGLKWRKEVGVQLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NLR1</accession>
    <name>A0A167NLR1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_102790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the PTH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294260.1">
        <property type="nucleotide sequence ID" value="XM_018427739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NLR1"/>
    <dbReference type="FunCoup" id="A0A167NLR1">
        <property type="interactions" value="159"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167NLR1"/>
    <dbReference type="GeneID" id="28988645"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_102790"/>
    <dbReference type="InParanoid" id="A0A167NLR1"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="entry name" value="Peptidyl-tRNA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224:SF1">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="Peptidyl-tRNA hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD76220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="144" mass="16009" checksum="75F79F870DCFA920" modified="2016-07-06" version="1" fragment="single">LVGLGNYTHPNTRHNVGMMVLDQIANKLDLTWTQNRTLKATISQTSLDIENKDKSRTRIDVTLLKPRLLMNVSGPSVSKAVREFSIDHSNIYVLHDDLQRPLGKVSMKSGGSANGHNGIKSVIQHLCSENFKRVRIGIGRPPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NZ10</accession>
    <name>A0A167NZ10_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_18833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294954.1">
        <property type="nucleotide sequence ID" value="XM_018439484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NZ10"/>
    <dbReference type="STRING" id="763407.A0A167NZ10"/>
    <dbReference type="GeneID" id="29000390"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_18833"/>
    <dbReference type="InParanoid" id="A0A167NZ10"/>
    <dbReference type="OrthoDB" id="2276331at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="239" mass="27599" checksum="A5C10A2750928D72" modified="2016-07-06" version="1" fragment="single">ISTVNWYANCLMYRSNSMHLLHRFGHLFQQYIVDMYAKIEHSRLGYYVLNQKKMRAELYSGIQDAVYLNDNDMTNLGWQVIIPSSFLGSPRCMRELYQDAMGIVHYFGKPDLFVTFTCNPTWPEITNSLLGGQSASNRPDLCFHVFHMKLEQLMHDLTKKHILAKVVAHVHVIEFQKRGHPHAHILLILAMADKPPEAFAIISRHMVHELCGEKVCLANVPLACYMKNGRCQKHYPKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P748</accession>
    <name>A0A167P748_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_141266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295418.1">
        <property type="nucleotide sequence ID" value="XM_018430553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P748"/>
    <dbReference type="GeneID" id="28991459"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141266"/>
    <dbReference type="InParanoid" id="A0A167P748"/>
    <dbReference type="OrthoDB" id="8951911at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047655">
        <property type="entry name" value="Transpos_IS630-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033545">
        <property type="entry name" value="transpos_IS630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13384">
        <property type="entry name" value="HTH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="205"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD77378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="394" mass="44982" checksum="3AD2CF4470E1172E" modified="2016-07-06" version="1">MLCEVPDIFAGHKDRKFNGRRASIEMIMSGSRIKAANNANKKIIKRSGRPQLTRSPHIRDLIIEKSANHLKSPTQISQELGIPRQTVCGIIKRFEKTGTIEYQSLGGDLRSIIQDHHRQFIINAVDENNTITLEELKTKLLEEFDDIHSISTSTLCNFLNNVERITLKGSTAMEEKRNYEETRRKRKKFISSLLREGILYNQNCIFIGEADFNISMIKGRSRSKAGLPAFVKTKTKRATSVTMLFALSAEGVESCHARVVKDDTTGLIFKEFVQQLVKKLDNANSGPCHLVMDNVRIHCNLSLRNWLQKRNKHKLKPLPPYSSFLNPVEECFSKLKNFVKKHPLDSEETLCERIKSSSYEITRQDCEGASQCISEAFKELSTCYQNHIVEMFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PXZ4</accession>
    <name>A0A167PXZ4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytosine-specific methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_77038</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="11"/>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296787.1">
        <property type="nucleotide sequence ID" value="XM_018443216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PXZ4"/>
    <dbReference type="STRING" id="763407.A0A167PXZ4"/>
    <dbReference type="GeneID" id="29004122"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_77038"/>
    <dbReference type="InParanoid" id="A0A167PXZ4"/>
    <dbReference type="OrthoDB" id="5577209at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006346">
        <property type="term" value="P:DNA methylation-dependent constitutive heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022702">
        <property type="entry name" value="Cytosine_MeTrfase1_RFD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF54">
        <property type="entry name" value="DNA METHYLTRANSFERASE DIM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12047">
        <property type="entry name" value="DNMT1-RFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037404">
        <property type="entry name" value="DNMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 9 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BAH" evidence="12">
        <location>
            <begin position="353"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037404-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD78747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1044" mass="119300" checksum="A3CBE84F0B605A0E" modified="2016-07-06" version="1">MIEIDGQEWPTINLAEIRNSDPKILIKEYNSHSKIRINKNKLTANRIHEKVGLSLMHLDNSKEWQEYTLDDFTFYSSNVDRPHSLNSMLARMRFKGTITDSIGRSVKVHSGEVTTRSLTGMTDDSKDLKVWLRSSTLKDEIYYLLKKPSQAYKPLFEDFLWSVRLSKIILSFLKSHPNATLEDTKYEGILNEHVYKEYPEEPWAKWNLFPHIIENALNIIDHIFYLCEDIPDEIISHQFWNNSLFEKIQNKLSGNPIKPPLYKDELTAVTPEAHTFYSPIFNNFLKLVKHKDSPKVNIKELPAASAVVIKDIFREQKMQNKYRVLDSNLWCLEDPLGFRNGCAKFNKVLVDTEFIHVGDCVQLRNDNNEIWIARVTSIFYTNPKNPLITIHWLYKSCDTLLESVSNRDEHFSKKELWYTHHCECESSEELSVTAIYRKVNVKFNSNWCPDKLHHYFCQSFYSHLNAWFEGLKPTHLKVSDQCQCQPLSFEDSLAEFKKRAVGDLVYLNHLHPTLLTLHEIVSLTDAAVELRPLLLIDQLPKEHISSCLPHNGRQLYNEVVYSKKTVNYSIAELVQGAHLEYIDTAHLEFYDPYTPLPNNLAHNGAGHHYYFNKVFDPKVNILSPLTASDEFGAKYPPWKPSAKKLATLDLFCGGGSFGHGLEDAGVAECKWAVDVCDPALDTYSINTKGSHTVYYESVNKLLKETINNNPRPNWPITGEVDFIIAGNPCQGFSRMNHHNQDPSSIKKSALLASVASYIEHYRPRFFLIENVANLTRFQYQHEKGSKGLFPFNQTIGLFVKLGYQVRWGVIDAASHGLPQARNRVFIWGAASGENLPQFPMASHVKLKKGLWGKGVSLPSGLRSDSVIQDNKTAFQKMTIKRAIEDLPSIPRKRKFPSEWADHETLSVGKDIQDIINIIPVDPVGLGLLEILKLYPKHPSLNSTYVDRLKKIKKKNPGNKFRDLKRVNPDNVIATVTTSPSFRGVQSVPAIHYSEARLLSLREYARAQGFLDTDVIIGPLRNKHRIVGNAVARPVAFALGLNVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q4Q4</accession>
    <name>A0A167Q4Q4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_62169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD79067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297107.1">
        <property type="nucleotide sequence ID" value="XM_018440917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q4Q4"/>
    <dbReference type="GeneID" id="29001823"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_62169"/>
    <dbReference type="InParanoid" id="A0A167Q4Q4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD79067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="329" mass="37769" checksum="76BFBA6F2762E784" modified="2016-07-06" version="1">MKADLHLSDYKNINNNTMAIQRRQLALRPVEITNEQLMEILSTLKTNMTAMGTNMAADMSIQNWCSSTETITAIDSLSRAPLVSPTNTMANVSQPAFNAPSEFSKKASNDVYAHIRNLMWDPKLKTRNQADILANESKPRWNTNVFFYKSPNKELVVRLLENLKRKFTHEGFREADLRARLHKNFTSRVSKARKTEEEIKATNTRLRRAGRARDNHTRRLLAYTDNKEAIDLQMKRDCDFTMQMAAMSDGESADEDFENRMKSIIKIVRPGWRSDEFNTLIKLVDEYVIEAMGSSASQMKERVFTSVSNTAVPDDITPKFPQWALRDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QAD6</accession>
    <name>A0A167QAD6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_162440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297406.1">
        <property type="nucleotide sequence ID" value="XM_018434624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QAD6"/>
    <dbReference type="GeneID" id="28995530"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162440"/>
    <dbReference type="InParanoid" id="A0A167QAD6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="191" mass="21504" checksum="35581805A8430980" modified="2016-07-06" version="1">MISVFWPFGPLVFCSFCFFFFIYKFSLFSLFPTFIIFTDFLDTCVLLPSDASPSQCSSRLAKVISLKLLSTIKHSYEHASPMYSLGLQINPFALGSILSTMVRIHDAFSFCLCACGKNPYTENANTSYYPAVLTFSYVRKLVLPPMNNSVIQLLQGIQDALISLKNGQEALEKKQDIIQLEITSLCNELKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QAI3</accession>
    <name>A0A167QAI3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_139398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297408.1">
        <property type="nucleotide sequence ID" value="XM_018430212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QAI3"/>
    <dbReference type="GeneID" id="28991118"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139398"/>
    <dbReference type="InParanoid" id="A0A167QAI3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="37931" checksum="01C67C0957A0C2F2" modified="2016-07-06" version="1">MPSNATRKSGRKGKQNAQGTLSCVAAGRIEQREIAPRVSPLAAGPSGAEAPGMTVESLTQVMAAINMMYDRTVEANTGIRFLVDAHNQAIAQQALVASSVTQGVTAANVSTNRHTKGEMHAIVLNLINRRMWARNFRSNDSELVAENKSRRRWNTDERIDHPDNVEVINYLRQYIVAQPRTAGFWEDMIVQKIKNNYKTCFRAVNATPEQASSKRRNNHINSRRIEQDTKMGYKPGNPDEMAYLHLLEKSVMSDGESEDEDVTPIICVQVLQVARPSWRSAELNRLIQFIDFLAAENDKKIATPQSKQRMLRYLKTIAVTPVPGHLTAILPVWTIQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QM64</accession>
    <name>A0A167QM64_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Agmatinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_176740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297954.1">
        <property type="nucleotide sequence ID" value="XM_018437816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QM64"/>
    <dbReference type="FunCoup" id="A0A167QM64">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QM64"/>
    <dbReference type="GeneID" id="28998722"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176740"/>
    <dbReference type="InParanoid" id="A0A167QM64"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000014">
        <property type="entry name" value="Arginase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF26">
        <property type="entry name" value="GUANIDINO ACID HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD79914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="40351" checksum="174ABEB72412B713" modified="2016-07-06" version="1">MKSTYIASIALYCTWALGSDAHPDHSSYETYDGYVPPFAGISTFAHLPYKQCWDEGVDEDYDIAVIGVPYDIGVTFRTGARFGPSAIREGSKRLKGYNDELKINPFRSWARSVDCGDIPFEPFDASHAIGQIESYTNYILQRPPTADGTPSRPPKLITLGGDHTILLPVLRSMRTAYKKPMTVIHFDSHLDTWAPEVYNVKAKQSRFNHGNPLYHAAIEGLTTNGSSLHVGIRSSLYDKQDVERDEALGFNIIKANAIFTLGVEGIVKRIHEILGPKEDTLVYLSIDIDVIDPSMAPATGTPETGGFLTREMRYILRGLDGYNIVGMDLVEVAPAYDTQAQLTSFLAADLIYEVLCMMVKRGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QRQ5</accession>
    <name>A0A167QRQ5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRELI/MSF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_27815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298189.1">
        <property type="nucleotide sequence ID" value="XM_018439919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QRQ5"/>
    <dbReference type="FunCoup" id="A0A167QRQ5">
        <property type="interactions" value="292"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QRQ5"/>
    <dbReference type="GeneID" id="29000825"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_27815"/>
    <dbReference type="InParanoid" id="A0A167QRQ5"/>
    <dbReference type="OrthoDB" id="407630at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="188" mass="21298" checksum="A16466BE8F071506" modified="2016-07-06" version="1">MKLFKSIHNFNYEWSLVSAANWQKYPNENCPHVQHVDVLNRFVDPETGTLTTERIITVDQKVPSLLRRILGADTTQYVHETSTIDPKTKTLSMKSKNLTLSNLLTIEETIEYTEHPEDPQQTQFTQQAAISAGSLVSRWSGIVEELSLKRFKDNAAVGREGFCKVLERFVVMAEAQHKPVSSTTDTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QY24</accession>
    <name>A0A167QY24_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_138011</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298490.1">
        <property type="nucleotide sequence ID" value="XM_018429916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QY24"/>
    <dbReference type="STRING" id="763407.A0A167QY24"/>
    <dbReference type="GeneID" id="28990822"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138011"/>
    <dbReference type="InParanoid" id="A0A167QY24"/>
    <dbReference type="OrthoDB" id="8093034at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF5">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="11"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="103"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="224"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD80450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="376" mass="41500" checksum="E4CDACB9AB460166" modified="2016-07-06" version="1">MIEYTVNEGCKTIRVSNLDTRITSKMLTDIFSMISSVKRVKITDIECGDDLSHGFIEFHEHQAAEQALQAMNGRAIFGQKIQLSWATNGYSTPLPETDNHVHQTIRVDHLSPDTKEEEVAKSFSVFPGMLNARIVWNPSTGKPKGFGLITFNTKENAENAMTTMTGKSIGSNKIECSWLDTAVKITNSPTITSTTISTDLKNKKATVANMTYEQIFAQAPLYNTTVYVGNLPRGITRQQIGPFFQQYGFVSDILERSNDGYALVKLDTHANASSAILALQGFNIGGQPIELSWGKDTMLQSNNEFYAGENLRKYTPGQAENNNWVLPGTGLCDYNTMRPPAPVAGSQGNTDNGTGVGQHGWNQYYQHYYSAGHQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R4H8</accession>
    <name>A0A167R4H8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Poly(A) polymerase</fullName>
            <ecNumber evidence="11">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHYBLDRAFT_138374</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Polymerase that creates the 3'-poly(A) tail of mRNA's.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="11"/>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298864.1">
        <property type="nucleotide sequence ID" value="XM_018429984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R4H8"/>
    <dbReference type="STRING" id="763407.A0A167R4H8"/>
    <dbReference type="GeneID" id="28990890"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138374"/>
    <dbReference type="InParanoid" id="A0A167R4H8"/>
    <dbReference type="OrthoDB" id="412748at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
        <property type="entry name" value="PolyA_polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="17">
        <location>
            <begin position="10"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="16">
        <location>
            <begin position="199"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="15">
        <location>
            <begin position="347"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="507"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="89"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="102"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="225"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAD80824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="578" mass="64248" checksum="2CB1F7A7F9AB7919" modified="2016-07-06" version="1">MSSVKPTYLGVSEPISIAPPSANDEKLNEKLEATLKDHNMYETKEKTCLRKKVLEILEALTKRMVENVYRKKGRSESEIMIAGGTIRTFGSYKLGVHAADADIDTVCIIPCYVTTTDFFDEWCSILQAQAGVKDVSAVKDSYVPVDLVCARISDPFVPVDIDVNSTDLLKKLSEKSLRSINGTRVADEILALVPDVTAFRTALRCIKLWATRRAIYSNSLGFFGGVAWALLVARICQLYPNACASTIVSKFFMVVAQWAWPSPVVLKAIQGGHGFSTLKPWNPKLSHHDRSHLMPIITPAYPNMCATHNVSQSTKTIILGELKRAATIVDRIMIGSSSWNVLFTEHNFFGTYDHYIQVVASSDTYECQLKWGGLVEARLRHLLLNLDSTDGVALAHPYVHGFDKAHLCQSTEELSAVINGIDTNGYPITSENSDDWKNKTGVYFTRTFYVGLYIKLNPAWTSKKVDITHAIEDFKAKLTESNSYEPARMSISFQQLKRSMLPREFIKKDSTKRSPQSNDLATQATPGKKMKIFGDSTTDQSEENNTSNDLSNTCHSLGATDYSPSPPSVSTTMDTNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R6Z9</accession>
    <name>A0A167R6Z9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate esterase family 4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_89037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299038.1">
        <property type="nucleotide sequence ID" value="XM_018443706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R6Z9"/>
    <dbReference type="GeneID" id="29004611"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_89037"/>
    <dbReference type="InParanoid" id="A0A167R6Z9"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF98">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="146"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD80998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="404" mass="45844" checksum="546649DC45E9C3C2" modified="2016-07-06" version="1" fragment="single">IIALCVLFTSTVVSQDSTSPNAPSPAQASPAYLSDIPIPQGVVLEYPRDEDVQWGDLPPIPDIDLSGYPARGELPSTDNPEVQNAMNYIDWTYVPLVDPREVVNWVVDTSQYDIASDPYCWWSASICKRPKLEYLPEDIYYCPNAGDWGLNYDDGPFKLLDRDHPDREWEQPRFYNSLVKYNKQKATLFFVGANVVSFPEAAQRALNDGHTICSHTWSHPYMTSLTNEQVVAQFYWTQKAIKQVLGITPKCWRPPFGDVDDRVRAIAWQMGMRTILWDQDSNDWNMPGTAGLGHISPDTVNGFFQAWVDKRVSGNDNEHGHITLQHENSNSTVAMSEKWLPELQSVFNVIPIHQCINDPSPYWEESFIYPTLDNPFPDQLELSANNNNQTKTQVTRDLSDGPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N669</accession>
    <name>A0A162N669_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_119444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441005">
        <property type="protein sequence ID" value="OAD66164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284204.1">
        <property type="nucleotide sequence ID" value="XM_018428683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N669"/>
    <dbReference type="STRING" id="763407.A0A162N669"/>
    <dbReference type="GeneID" id="28989589"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_119444"/>
    <dbReference type="InParanoid" id="A0A162N669"/>
    <dbReference type="OrthoDB" id="2439011at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="182" mass="20361" checksum="4016DA8438D7E994" modified="2016-07-06" version="1" fragment="single">MNNLPREERMKPENIILVGVMPGPKEAKINQMNNFLEPLVDELVELYGGITMKTPEFPNGTSIRAALMCVACDIPAARKTAGFTGFASTNACHICKHHFTVVAGTSKINYSGFDHENWVSQTKEENATEAEMWFCAESDAERAVLEKQHGTRFSELHCLHYFDPVRCTIVDPMHNLFLGTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N9C2</accession>
    <name>A0A162N9C2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_151996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD67054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285094.1">
        <property type="nucleotide sequence ID" value="XM_018432803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N9C2"/>
    <dbReference type="GeneID" id="28993709"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151996"/>
    <dbReference type="InParanoid" id="A0A162N9C2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="152" mass="17206" checksum="1000A922A4B102E6" modified="2016-07-06" version="1">MIGLQYSLIKELPIIQNQDVQEEREEVSATVQDKLHCLEFVEIQINLLKKIEQTVTKRNAMVMDNLSGMDVSVQILRDCLSFSEEAGAAPQQKRAANCATEAFMNVMCIVHNSINWPCCGARYWKVSLLGGFVQWFVVTCRPGYERLTSTVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NAZ2</accession>
    <name>A0A162NAZ2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_177616</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290768.1">
        <property type="nucleotide sequence ID" value="XM_018437906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NAZ2"/>
    <dbReference type="FunCoup" id="A0A162NAZ2">
        <property type="interactions" value="188"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NAZ2"/>
    <dbReference type="GeneID" id="28998812"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_177616"/>
    <dbReference type="InParanoid" id="A0A162NAZ2"/>
    <dbReference type="OrthoDB" id="106623at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000023">
        <property type="entry name" value="Probable uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="16"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD72728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="219" mass="24253" checksum="3C6FACB200595AB3" modified="2016-07-06" version="1">MSSGYKLPSQVQLLHQTSQLKGLMTIVRSKETQRGDFIFYADRIIRLLVEEGLNHLPVINKAIETPTGSKYSGLSFEGRICGVSIMRAGEAMEQGLRECCRSVRIGKILIQRDEETHQPKLYYAKLPKDIASRYVLLLDPMLATGGSAIQAVKVLLDNNVKEERIIFLNLIASPEGIASFIEQFPKIKIVVGEVDAGLDAAKYIVPGCGDFGCRYFGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NHT0</accession>
    <name>A0A162NHT0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_9242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287834.1">
        <property type="nucleotide sequence ID" value="XM_018443786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NHT0"/>
    <dbReference type="STRING" id="763407.A0A162NHT0"/>
    <dbReference type="GeneID" id="29004691"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_9242"/>
    <dbReference type="InParanoid" id="A0A162NHT0"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF133">
        <property type="entry name" value="COA BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD69794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="81" mass="9092" checksum="B44C1B166BE00D99" modified="2016-07-06" version="1" fragment="single">FCRALAVVRTLPDNDTVQLTASERLNLYGLYKQATQGDCTQPKPSSRDVAECAKWKAWDRLQGLCPTDAQTFYVEALVELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PIX3</accession>
    <name>A0A162PIX3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_155430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291337.1">
        <property type="nucleotide sequence ID" value="XM_018433403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PIX3"/>
    <dbReference type="STRING" id="763407.A0A162PIX3"/>
    <dbReference type="GeneID" id="28994309"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_155430"/>
    <dbReference type="InParanoid" id="A0A162PIX3"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06606">
        <property type="entry name" value="STKc_MAPKKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD73297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="298" mass="33253" checksum="B8CA9A4694EFC9FD" modified="2016-07-06" version="1">MIGKGSFGAVYHAYNYDAEEWIAVKVVNLPESGNPGSSSLFVDTKRQEVIDEIFRETEVLINVQHPNIVEYLGSDIDMKSGKVYMFLEYVPGGSISACLRNNGKFDEPLVRNFTRQILEALEYLHSKDILHRDIKGANILIDNNGVCKIADFGLSKTVAKYEAYNENAQNSYMRGTLNWMAPEMIKSGVYNGKVDIWSLGCTVVEMLTGKLPWSGVNNNNTVIFKLGSGESPPMPTGISDLAKSFIEKCLTIEPKDRPSAEELLSHPFISKDPSFDMMTEVVKLGLERKVSRRVVAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PL89</accession>
    <name>A0A162PL89_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_168321</name>
        <name evidence="2" type="ORF">PHYBLDRAFT_64851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291914.1">
        <property type="nucleotide sequence ID" value="XM_018441358.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291937.1">
        <property type="nucleotide sequence ID" value="XM_018435837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PL89"/>
    <dbReference type="GeneID" id="28996743"/>
    <dbReference type="GeneID" id="29002264"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168321"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64851"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD73897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="168" mass="18603" checksum="D5F7553AD438CD27" modified="2016-07-06" version="1">MDYGSWIIDYYFWLWFCGSGFLAVFSDRCQTSDTMTPCLCPKNGKKVKKKHILSIQKRIISKCQRRQSSTTNTASRVSTFTSSMGQCIKGLASVKKAFSCKKAQTTATPSLISSSSTISNDSYLSDLSDDEHFSKSCPVSEKSMALDSLIFDHPSVTVRISPAAYRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PNB0</accession>
    <name>A0A162PNB0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDB1- and CUL4-associated factor 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">WD repeat and SOF domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_155273</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292507.1">
        <property type="nucleotide sequence ID" value="XM_018433393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PNB0"/>
    <dbReference type="FunCoup" id="A0A162PNB0">
        <property type="interactions" value="1055"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162PNB0"/>
    <dbReference type="GeneID" id="28994299"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_155273"/>
    <dbReference type="InParanoid" id="A0A162PNB0"/>
    <dbReference type="OrthoDB" id="10249065at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000132">
        <property type="entry name" value="DDB1- and CUL4-associated factor 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="62"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="12">
        <location>
            <begin position="181"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="273"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="316"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="11">
        <location>
            <begin position="349"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="399"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="399"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD74467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="441" mass="50229" checksum="3D45144567F07CC4" modified="2016-07-06" version="1">MKVKALSRSTSDYVRERAQDTHKVQRNLDPALHPFEKGREYVRALNTVKLERLFAKPFVGALSGHIDGVYSMAKHPQKLSSIISGSGDGELRVWDLSEQATTWRTKGHTSIVNGVCAGHHTGQFLSCSSDKTVKIWNQSVGTDPIETYMGKNAFTGLTHHRSDPIFATSGHTVDVWDETRSDPIHSFEWGADSYQTVKFNQVETNILASCGQDRTIVLYDLRTSKPLSKLVMAMKTNAIAWNPMEAFIFTAGSEDHNAYTFDMRNMKAAQNILKDHVSAILDVDYSPTGQEIVTGSYDRTLRIYNSRSGHSRDAYHTKRMQRIFCVQFSMDSKYVLSGSDDGNIRLWKAKASEKLGVKDWREKNHLEYAAKLKERYSHMDEIKRIDRHRHTPYGVKRADSIKKEMLSAQKRKEDNRRKHSKKGTEEKRVSEREKAIIGIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PUB0</accession>
    <name>A0A162PUB0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_168465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD74056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292096.1">
        <property type="nucleotide sequence ID" value="XM_018435873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PUB0"/>
    <dbReference type="GeneID" id="28996779"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168465"/>
    <dbReference type="InParanoid" id="A0A162PUB0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD74056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="271" mass="30843" checksum="60756893119E7473" modified="2016-07-06" version="1">MNNIIKKNTPRTKSRYLKLIVTHIIFTVARSLLMKMAPRTPRNTRRRSTSSGESTSLSQVIAGYVGRHAIVSQQVPVSSSDEHLNQMSLDLQGFIMQLAWMNCKVGQLMDGQRRNIGAAARQESMPASLPALAPSSPLSVPAMPEQEMGSLILVLINRKIWKRNLKFRDSSVIAENEARRRWNVTECINHPENAALVDYLCQYILAQPCARDFWSSMVLKKFLRGRIQDLKLGTKIRENLCSPDEVLTSKVNVFMSYNYAYNNPLMYPILW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PVG3</accession>
    <name>A0A162PVG3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_166339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294407.1">
        <property type="nucleotide sequence ID" value="XM_018435404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PVG3"/>
    <dbReference type="GeneID" id="28996310"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166339"/>
    <dbReference type="InParanoid" id="A0A162PVG3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="125" mass="14403" checksum="DB08D55F2E35DD82" modified="2016-07-06" version="1">MRDFIGLGYSELTKDFRTCEGQQPSTLHRIRPIPTKIFVKTVIIPTHFQITVILSSSIVFFSEEFLIFSICCCFFTTSVPIVLNAVKRKYNININTSTNPNTSSNKRIVIFDYYADFNNCDKNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PVJ2</accession>
    <name>A0A162PVJ2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_98615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294437.1">
        <property type="nucleotide sequence ID" value="XM_018444060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PVJ2"/>
    <dbReference type="STRING" id="763407.A0A162PVJ2"/>
    <dbReference type="GeneID" id="29004965"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_98615"/>
    <dbReference type="InParanoid" id="A0A162PVJ2"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035621">
        <property type="term" value="P:ER to Golgi ceramide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000001">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF203">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD76397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="45709" checksum="D9E4C2CD817CEE8E" modified="2016-07-06" version="1" fragment="single">RRKTLPSPSVGDPASAISIFRKNVGKDLSQVAMPVSMNEPISILQKACEDLEYSELLDKASSMDDPMDRLMYVAVFAISSYASSQYRTGRKPFNPMLTETYENIRPDKGFRFIAEKVSHHPLVIAAHADSKNYKYWQASKVKSKFWGKSMEFMTEGTFHVTFTGHDDHYTYFKPSSWMRNMIAGEKYLEHVGEMKVQDHTSGAYASVTFKEGTGGGLFGAPTKRDEVVATLYDSQGKKCRRVVGKWSELMAEEVDMNGSTLSILWHANPPHVKDYQKYYGFTRFCVELNEITAIEDHKLPKTDSRLRPDQSLYEQGHVEEADKEKQRIEQLQRERRKEYEQKGIECKPRWFKLENDPFEEFQLAPVEGQESKGLSWHYNGNYWQTRESGQWPDDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PY73</accession>
    <name>A0A162PY73_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_104195</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293366.1">
        <property type="nucleotide sequence ID" value="XM_018427824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PY73"/>
    <dbReference type="STRING" id="763407.A0A162PY73"/>
    <dbReference type="GeneID" id="28988730"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_104195"/>
    <dbReference type="InParanoid" id="A0A162PY73"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071248">
        <property type="term" value="P:cellular response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000181">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD75326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="75" mass="8883" checksum="F8C77CBC654CCF34" modified="2016-07-06" version="1" fragment="single">CQHPTCSKYFTRPYNLVSHMRTHTAERPFACSQCDKRFARQHDRNRHEKLHSGVKPYVCPECDKPFARQDALGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q6K0</accession>
    <name>A0A162Q6K0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_161189</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298586.1">
        <property type="nucleotide sequence ID" value="XM_018434354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q6K0"/>
    <dbReference type="FunCoup" id="A0A162Q6K0">
        <property type="interactions" value="78"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162Q6K0"/>
    <dbReference type="GeneID" id="28995260"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161189"/>
    <dbReference type="InParanoid" id="A0A162Q6K0"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045260">
        <property type="entry name" value="Sec12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF0">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD80546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="442" mass="48156" checksum="FA55B51C06D27FA5" modified="2016-07-06" version="1">MLNCPTFSVSVGIPIFGLGFTSTNHLIIGGGGGGGRSGVKNKLSAYRIDGKRRDLEEEAVYEVPEGEDAPMCLAVHPTDHSVVAGINASKKEIEAGVNKHCRVFRVTEEKWVYVNFTLHNAVQISTSKKEEEYQKVVRFSEDGSLVAVGTSDGHAEVFKYPSFESNGPTIKFDDEVLDVDIGLENDKLTCVTRDAIKLVTIRGKNSGKILQTLPVSAINKKRRLQFRSFRYGRGAVKDVGFAVVNGVDKPAGYVVRLNPYTFETIKVHQVSKKPITAMCTSFDGAILAIASSDLSITLFDASSMQILTHIKNAHNFSITSMAISTDRRTLASGSADNTCRIIFLPLQFPPISVNPFHTLFLALAIAGTLLWLTTMFNAGDLDESFAQERTVSSRPVKVVATTKIPLSNVIVPVSSPTTEFVPIETIESSTFVSQSTEARDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162QAW4</accession>
    <name>A0A162QAW4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mob1/phocein family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_120964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299536.1">
        <property type="nucleotide sequence ID" value="XM_018428770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162QAW4"/>
    <dbReference type="FunCoup" id="A0A162QAW4">
        <property type="interactions" value="111"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162QAW4"/>
    <dbReference type="GeneID" id="28989676"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_120964"/>
    <dbReference type="InParanoid" id="A0A162QAW4"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD81496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="25184" checksum="574CFB90498BEF87" modified="2016-07-06" version="1">MSFLNFSLGGKRNKAAKSKSSSTSQSKPLFLCNPYVTHMLVKGNFKTIIELPKYVDVNEWLAFNTFEFFNCLNLVYGSINDFCTAQSCPTMSGGPGVEYTWSDSVSKKVKLPAPQYIDFMTASIQNLLDDESLFPTKAGRDFPAREMPAAVRKVFSQLFRLFAHIYHHHYDKILSLHEEPHFNSLFAHFISFAREFDLLDKKETQPLQELIDTMSKNGVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T9W7</accession>
    <name>A0A162T9W7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_151716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Fungi incertae sedis</taxon>
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            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
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                <person name="Braun E.L."/>
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                <person name="Horwitz B."/>
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                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T9W7"/>
    <dbReference type="GeneID" id="28993635"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151716"/>
    <dbReference type="InParanoid" id="A0A162T9W7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="91" mass="10375" checksum="D703F100649DCFEE" modified="2016-07-06" version="1">MYVNKHIHFNNRTSNRADSACASLKHSLGTSSGKLKTVTLKVKKWYDELVANHKHRLMMESLGEGTKVVFNKVNAARLNDIRLKVCRFAMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TAS3</accession>
    <name>A0A162TAS3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_160804</name>
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    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Fungi incertae sedis</taxon>
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            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Bud4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="168" mass="19561" checksum="9AC8A6893D6052CE" modified="2016-07-06" version="1">MSRYETLGQDVNFDYECIIDTYPDMIITVSLHVRPDQHVRSKAPITRLFTSTRKRKETLSGYVSQYDGAIGQTRFALVHMLHACYQKPYEANFDCFNAWYDRSSREKQREKKNGPDQDILKVVGSLSIETLYLPVMDPLQPVPLTLKECNMALQAYQWEEKQQSGRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TM81</accession>
    <name>A0A162TM81_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_188319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287672.1">
        <property type="nucleotide sequence ID" value="XM_018439483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TM81"/>
    <dbReference type="GeneID" id="29000389"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_188319"/>
    <dbReference type="InParanoid" id="A0A162TM81"/>
    <dbReference type="OrthoDB" id="2274850at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD69632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="499" mass="56953" checksum="7850F1F35DEE20B6" modified="2016-07-06" version="1">MNNAIQDSNQDTIPNESQSQSSKKTPQEINLSLIHYILVSPFAALYIVGRALLDVLRLGVYWILWLCEQAGPRIDNWLFETVTESIPSRLGQLERWWNDRGLVWCRECIDYINKAVLPAVVTGVERGFGWFCSICAAINVGWTAACHTYTAIVNMHDWQALFLKIWRPLESFCYRTHRILVLVYRVCYSGAISLWEDIRSIYGGLSLVFDTVRSSWLAGKIIDAIRSGVAWSSANFQPVLDKLHKQVILPVLTISGVLAVYTVERIARVLESDGFRTRILRFRQALFSNLVWAVLDLLDMVKDINIWVGCLINTVVVPTVILFVQHLLPRLSKAHQRLRYVAIGVFENQVYPVWVRIYPHTRPLLELCHKICALAVSQDWIVERLGWLNKWAVSGCRRMIENVGPVVYSATEILSRCFWSVCEWMGSQAPLVAKAMEQMRRLVEELDWAGLQRDGLAVYWVVYDAVSVQSDLLFGSLERALTTCELEQSTAKSKGSKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TXM4</accession>
    <name>A0A162TXM4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PI-PLC Y-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_72696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289862.1">
        <property type="nucleotide sequence ID" value="XM_018442695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TXM4"/>
    <dbReference type="GeneID" id="29003601"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_72696"/>
    <dbReference type="InParanoid" id="A0A162TXM4"/>
    <dbReference type="OrthoDB" id="2262863at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF34">
        <property type="entry name" value="NOTOCHORD-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007840116" description="PI-PLC Y-box domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="2">
        <location>
            <begin position="391"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD71822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="865" mass="98148" checksum="57292D65F9785251" modified="2016-07-06" version="1">MLALAESVLMLLMLSFFIRTCKLLASKCKPNGPSHHICLLSCFRTLVLMSLHLLITTELDDDASKLTKVPAKPTKLAMAAISTWRNMMSSVTNLNSPVDEDVDWLNSLLGSCLTWNSNTSTTHPFPDLQSMVLLALVDGDNNMFSCRILKKILFTIRLVLKLQEEAITNGSPFKLSRLDALLNYQSRKKSKLPVLTSIPVTIDLLKNKSVLAYVNMPSDHLKLLATNPVKAKSMFAMPDHMPDQFVCLQQGKKWRTHKNFQQPMFTHNKIDFWSGMLLSLPVALPMPVSFYNVLLPENNHFVHIETKRTSMRVKKLLQVDASPIDIDFCFSVSPRKIDPVLPVHWSLLLVPHFLKRHIPQDLDNLNNKNHFYKVRIAMITLFTNDMLGSWSKQYNPYKSWSMKCAALSFEEKSLIENIYFLSAILKKDGASGMSLLPVFVKDLKMLEAGLVMFSAEDNEHVLVVGPLLWIEADTPCHSELCGLRASTCLTAEKLKDEIHYTGSHASRTKERYQIATSTPDRSSTILDAPLTGKNFKASELSFQYMAMNVLLDLDSFDPSTNTPVEILHNILLGVAKYLVTDLVKVVLKGHPGLLNKLIDSLNEYEKSQGLSRKFTRLLRHCGSFLGRDFKILVQILPIVLATEFVNDNDLSLITPCFVHLGRLCSLVFVRAVNLIQKLYFYDKNCGIEGHKPYTSKPKVQLLTHLPDDLQRFGTALHYETEKGEQFNKHIREHLMHTNRLNTSRDVCLKFAKQAVMRHVIDGGSWMNKDGQREHYGGDTAVFLHENVDKNFQDILFGRLRDFANNNDIDNIADLPPRNNTFGVFVLNESRDQPVHYIIGKVSSLRVEHYRVESSAHGQENNFLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TZF9</accession>
    <name>A0A162TZF9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_72489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD71083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289123.1">
        <property type="nucleotide sequence ID" value="XM_018442662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TZF9"/>
    <dbReference type="GeneID" id="29003568"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_72489"/>
    <dbReference type="InParanoid" id="A0A162TZF9"/>
    <dbReference type="OrthoDB" id="4843387at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="240" mass="27010" checksum="3DE804A5BD6473FC" modified="2016-07-06" version="1">MSHQNKKESLPKRKQLSDYQRGLIVGGAIVNGTAAEISEKNDISLATVYSTINRWRDTGTAFSDKRKETLKIIDERDECHLINEIKTNRETTLGGLTTFMSDTLGIPSPSLLFIELFVDLDYLLVKLYTSHCYQKHTRRSSWNLLIMPERPIRDGIASSGVMSQGLCFSAEMTILEYGGILKKNTEKSSLDQDCSVVEAPLWFGAVKLLPFMESLSENNDGEFIYQEDNASCHKSKVAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U5C5</accession>
    <name>A0A162U5C5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_74696</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Lipid-anchor</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291602.1">
        <property type="nucleotide sequence ID" value="XM_018443031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U5C5"/>
    <dbReference type="STRING" id="763407.A0A162U5C5"/>
    <dbReference type="GeneID" id="29003937"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_74696"/>
    <dbReference type="InParanoid" id="A0A162U5C5"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04139">
        <property type="entry name" value="RalA_RalB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000203">
        <property type="entry name" value="Putative ras-related protein ral-a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD73562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="194" mass="22479" checksum="E4A89EABF53196AD" modified="2016-07-06" version="1">MAKKTKNAMTLHKVIMVGSGGVGKSALTLQYMYGDFVEEYDPTKADSYRKKIMLDGHECDIDILDTAGQEEYAAIRDNYYRSGEGFLCVFSVCEYESFEHAQEFRDQILRVLDDDTIPFILVGNKVDLEHLRKVTTEEAQQLAQEWNCNYMETSAKTRYNVENVYTMLMRQIRDRKEQMSMTDSRSKKGKCIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U707</accession>
    <name>A0A162U707_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_103098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292012.1">
        <property type="nucleotide sequence ID" value="XM_018427754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U707"/>
    <dbReference type="STRING" id="763407.A0A162U707"/>
    <dbReference type="GeneID" id="28988660"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_103098"/>
    <dbReference type="InParanoid" id="A0A162U707"/>
    <dbReference type="OrthoDB" id="2435678at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="60" mass="6710" checksum="62532BDFCB81157B" modified="2016-07-06" version="1" fragment="single">PPHRASVVENNKIGALIDEMLRNGIIAPSHSPWSPPVVIVMKKNGSPWFCVDYRRLNSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UGQ9</accession>
    <name>A0A162UGQ9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_144435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293123.1">
        <property type="nucleotide sequence ID" value="XM_018431221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UGQ9"/>
    <dbReference type="GeneID" id="28992127"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144435"/>
    <dbReference type="InParanoid" id="A0A162UGQ9"/>
    <dbReference type="OrthoDB" id="2282690at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="233" mass="26375" checksum="CE6B59C91D0CF5D5" modified="2016-07-06" version="1">MSNQQSACTQRESFGQKMANLYTWNKICVLSMNAIYLLSIFQDFYDAGNHIIEGKYSTEGYRAIPAGAVVTIITSSIMMFCLLFDMVVMSTNKLSLAYHYWRPGLFFFAVNCSGKGINMMRMLLNSSEYIRDCEYKIISVELSPHSLVSTMCHIDVRLTNLTAAMALVRDVSICGLYVVLSHMHLAKLVTRLKKQQSTVMDMPLTLIRYQTPRINGTSSPTFSEAPTLIDNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UI03</accession>
    <name>A0A162UI03_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_59890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294392.1">
        <property type="nucleotide sequence ID" value="XM_018440575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UI03"/>
    <dbReference type="GeneID" id="29001481"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_59890"/>
    <dbReference type="InParanoid" id="A0A162UI03"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="105" mass="12127" checksum="DBFDF38FE56450C5" modified="2016-07-06" version="1">MSLRMCCVYSPLVCLGNINFAQSMDRWLLSTLLPTPLIFSSYYFFHFPFGASQFIEYIRLNIRVKKKGFGYKGIEVLQTTATCTSKCIPKWRAIGLDKMIEPNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UI70</accession>
    <name>A0A162UI70_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_180661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294442.1">
        <property type="nucleotide sequence ID" value="XM_018438347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UI70"/>
    <dbReference type="GeneID" id="28999253"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_180661"/>
    <dbReference type="InParanoid" id="A0A162UI70"/>
    <dbReference type="OrthoDB" id="2291008at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="351" mass="39958" checksum="557C5E907E944C50" modified="2016-07-06" version="1">MSYYHQQQLQQQQQQLLLLQQQQQQQFEYQRYSYGQNSSHSRHTSNTSSHHRNLPSLSSSVSSCSSSSTCGSPVNRQQTSPYYYYSSPPPSPSVRTPSPSRTSEAQWQAYSATIRAKRATAPMPLRSVSADSLTYENIVDEKPSRHSYEKTGRNSYQSYQSRYSIEYAYPVYSQRANPLDRDFVSCEPHSPTESRKSRRSSNASARRVSFNDRVVVISPLPVHPPEERLVTLTAIDDDSVSWNISRPSLKKQSSASTVVEPSCSENEKYDAIVKQCTNRSASQIWWDESQLAVELAEDDLLQEPKRNNSMNQLKKLSVSAFKTSSKKEPSCSQPKGSRLGRTLKKWKKLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ULD6</accession>
    <name>A0A162ULD6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_16235</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294173.1">
        <property type="nucleotide sequence ID" value="XM_018434606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ULD6"/>
    <dbReference type="STRING" id="763407.A0A162ULD6"/>
    <dbReference type="GeneID" id="28995512"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_16235"/>
    <dbReference type="InParanoid" id="A0A162ULD6"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF41">
        <property type="entry name" value="CHITIN SYNTHASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD76133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="483" mass="54424" checksum="1BE1BFF2B0915C96" modified="2016-07-06" version="1">MANPEPKSYLAVADGEKQLNMAKVYAGHYKGVPCVTVIKCGTEEEAAGPKPGNRGKRDSQLILMSYFQRVLFNDRLSELDYEMFWKMTWLMKGVTPDKFEVVLMVDADTKVLPDALTYMVAAMANDITIMGLCGETRIANKRTSWVTAIQVFEYYISHHYAKAFESLFGIVTCLPGCFSMYRIKSPKNGSWVPILANPDIVMEYNQNIVTTLHEKNLLLLGEDRFLSTLMLRTFPKRQMMFVPQARCKTVVPDEFSVLLSQRRRWINSTVHNLMELVLVSDLCGIACLSMQFSVFIDLIGTLVLPAAICMSIYLIIDSAISVNPQWQSLGLLLAVLFLPAVLIAVSTLKFIYVCWMIVYICALPIWNFVLPVYSFWHFDDFSWGATRVVVGEKKGASHGDAEGTFDSSRLTMRKWEDWEAERTGQNFSKGIKVLQTPGGTYSYEGARQSPSPSPFTTIFNDRKMFTSPAQTNNSAISQTSTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UQS2</accession>
    <name>A0A162UQS2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_116135</name>
        <name evidence="13" type="ORF">PHYBLDRAFT_142761</name>
        <name evidence="14" type="ORF">PHYBLDRAFT_164420</name>
        <name evidence="11" type="ORF">PHYBLDRAFT_183390</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285893.1">
        <property type="nucleotide sequence ID" value="XM_018438763.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287507.1">
        <property type="nucleotide sequence ID" value="XM_018428502.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293801.1">
        <property type="nucleotide sequence ID" value="XM_018430866.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295552.1">
        <property type="nucleotide sequence ID" value="XM_018435000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UQS2"/>
    <dbReference type="FunCoup" id="A0A162UQS2">
        <property type="interactions" value="499"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UQS2"/>
    <dbReference type="GeneID" id="28989408"/>
    <dbReference type="GeneID" id="28991772"/>
    <dbReference type="GeneID" id="28995906"/>
    <dbReference type="GeneID" id="28999669"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_116135"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_142761"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164420"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_183390"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000211">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD67853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD69467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD75761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD77512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="458" mass="49814" checksum="EBDC53633172C2CA" modified="2016-07-06" version="1">MGKEKTHVNVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDKLKAERERGITIDIALWKFETPKFMVTVIDAPGHRDFIKNMITGTSQADCGVLIIAAGTGEFEAGISKDGQTREHALLAFTLGVRQLIVAINKMDTTKWSEARYNEIVKEVSSFIKKIGFNPKSVPFVPISGWHGDNMLEESVNMGWFKGWTKETKAGVKSGKTLLEAIDNIDPPVRPSDKPLRLPLQDVYKIGGIGTVPVGRVETGVIKAGMIVNFAPAGVVTEVKSVEMHHEQLVEGLPGDNVGFNVKNVSVKDIRRGNVCSDSKNDPAKESGSFTAQVIVLNHPGQIGAGYSPVLDCHTAHIACKFAELLEKIDRRSGKKMEDAPKFIKSGDSAIVKMVPSKPMCVEAYTDYPPLGRFAVRDMRQTVAVGVIKAVEKVDKASKVTKAAAKAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162URN5</accession>
    <name>A0A162URN5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Required for respiratory growth protein 7, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_60484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295393.1">
        <property type="nucleotide sequence ID" value="XM_018440649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162URN5"/>
    <dbReference type="GeneID" id="29001555"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_60484"/>
    <dbReference type="InParanoid" id="A0A162URN5"/>
    <dbReference type="OrthoDB" id="20734at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018828">
        <property type="entry name" value="RRG7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133:SF1">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10356">
        <property type="entry name" value="RRG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD77353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="22351" checksum="06746AB95E019EE1" modified="2016-07-06" version="1">MALFSKRVLTGTRSKALQQSGLDSFLKQSIHKDPTSSVYLGTMFEMQTMEALQTIGMDLSHVGGKGDRGVDLSGEWPLALSSTFAVPRLIVQCKRLQKGCSPDHLRSLVGTVVNMAHPTQPTIGILATLGHRPFTKELSGHFLSSQVPLGLAMVDENCLKSLVFNLPAQEILQGVVVTTRYTAAGDRVPVVTFKGQVIDIENKMCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162URQ5</accession>
    <name>A0A162URQ5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_185590</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295712.1">
        <property type="nucleotide sequence ID" value="XM_018439100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162URQ5"/>
    <dbReference type="STRING" id="763407.A0A162URQ5"/>
    <dbReference type="GeneID" id="29000006"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_185590"/>
    <dbReference type="InParanoid" id="A0A162URQ5"/>
    <dbReference type="OrthoDB" id="2914378at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="195"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD77672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="469" mass="53314" checksum="0AB712D6761A46DA" modified="2016-07-06" version="1">MLQGRTSQQTPTPLTQHGRDMLASIKDGRHRATGAFTKRSSLGNLRKSKSSTTADNQLAARTSDLLTVDMRMKRRSTGCLRRPSFLNAAKAATNTTIPPQNTRVWRPPGCYEIPNILGSDCFLKPDPPMDDAKAYGFRTSNPTKHISKRPWLPAGPRSEIPQLPPFVRPENAFERSIRKAVPKIQVSSLDPRNKYGGFKEVGTGVNGSVVRATHRYKKNIHLAIKRCRLDPDREYKAALVRELRIMATGHPNLIRLCEVTLWREDVWMCMDLQRCAVFAILCQRGIPEEYTVMIACEALKGLVYLHTQGYIHRDIKCENILVGWNGEVKLADFGLATRSNRRNRDRLGTSKWMAPEVIREQYYNEKIDMWSLGITLIEMMDRVPPHYLIKDEVELFATILSNPSPTFTYSYPTMYMRGLVAWLLDEEPRTRPGAKDVLAEIEAHIQSNLLRCASTTEFARFANQVLPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V251</accession>
    <name>A0A162V251_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_184781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297502.1">
        <property type="nucleotide sequence ID" value="XM_018438987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V251"/>
    <dbReference type="STRING" id="763407.A0A162V251"/>
    <dbReference type="GeneID" id="28999893"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_184781"/>
    <dbReference type="InParanoid" id="A0A162V251"/>
    <dbReference type="OrthoDB" id="2108at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43799">
        <property type="entry name" value="AMINOTRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43799:SF1">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="1">
        <location>
            <begin position="41"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="383" mass="43098" checksum="64136EED870EFFEB" modified="2016-07-06" version="1">MTSKASNNNSGNNTWDSKTQTFHGGQEHFFIDNFVEDFSVTTNYLGTPKKALEAARIAMGQIHHYPAANQEPAKSRLAEFLWPKNFAEHHGRLLMGNGASELIDLVVRKALDQARERGIKNPTWKGGPWNVQYQEYQRSAATNGFKILDPSSKERADMICIVNPCNPTGDYLPIEEIKGWLEQNVAPKGTVMVDESMQLWHSADFRADSLINQHEFMLSMLERDQVSVHVMHSWTKIWSCTGLRVGSVICPTAQHCEALKKIQVPWSVNGPALKFVEAVVKDDEYLNKTWENTSRLRAHLISELEKIKGFKQQGWVCHGEPFLSWVWLDVRSDEVATKAVDLARAAGVPVRSGKPGYGCNTFVRIAVREEHQAAILISAWASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WGA7</accession>
    <name>A0A162WGA7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_151894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD66955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284995.1">
        <property type="nucleotide sequence ID" value="XM_018432777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WGA7"/>
    <dbReference type="GeneID" id="28993683"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151894"/>
    <dbReference type="InParanoid" id="A0A162WGA7"/>
    <dbReference type="OrthoDB" id="2425068at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="403" mass="46362" checksum="898029FD0F0C4F8C" modified="2016-07-06" version="1">MLRSKISKGFPFMKADEWKSWCLVYSPVVLQGVLPKQKFENWMFFVNACRFLTKPNVSEDDVQSAHIALEKFGKGCERLYSKDLLSPNMHLHLHLRDTIKDFGPVYGYWLFSFERYNSVLKNINTNRRSGFEMTYMKTFIEDTHKGDFVRNFLKTSGPFNFSGIFDKLVTGYSPADSTTSTALYNWFSLPDFLDAAENPNLSIRGNEPLPPSALPLQKKAYEMMLRQEYDCLVGYYQAVYNDPTISSCKDVIQDTAFVNDWIEMLKSVNLLGQTFKGSRGTNGRGLYIQAMFIEGRNGAKYAYVGEIQYLFVHSFSPLVSTPHHRTPQSSQHTFAYVKWYKASKETSRKIAGVEIWDVAFSLPDFQSILPVHRILLPVAIVDHTTLRNISKKLIVPLPRKLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WUA8</accession>
    <name>A0A162WUA8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_64030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288935.1">
        <property type="nucleotide sequence ID" value="XM_018441223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WUA8"/>
    <dbReference type="GeneID" id="29002129"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64030"/>
    <dbReference type="InParanoid" id="A0A162WUA8"/>
    <dbReference type="OrthoDB" id="2257766at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11743" checksum="90CFFBC1B903370E" modified="2016-07-06" version="1">METVETRDHPREKLMFCDHFTIFNFHSTRAAASTVAAQGGMDIVAVKQHANWSLTSNTFERYYYKPNSRYEQVAEMVDQIIFMDTIYDTISEGAGEDAAIPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WYH8</accession>
    <name>A0A162WYH8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_170194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289565.1">
        <property type="nucleotide sequence ID" value="XM_018436285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WYH8"/>
    <dbReference type="GeneID" id="28997191"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170194"/>
    <dbReference type="InParanoid" id="A0A162WYH8"/>
    <dbReference type="OrthoDB" id="5514950at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="638" mass="71846" checksum="5269ED12F1B411A5" modified="2016-07-06" version="1">MGSFLGDHTITLRGTSFLQWIQATGLTCWNELLAFGIPTFLSGGSGISRSSVIDLFLSTSPLLNPSMQIRSDLSLGSDHKMVNLTFTPYVLPPPPPTSHPRLLWNLSKLAQPDTLKIYIDTASGSLDDLTEQFSAFLSSSSPPPVDSLCSAFAQAIYDTLDTAVGHRTPRTMQKYWFWSVDLQEAMDLRERSYQCWHHSSGLQKAICWMRHQDACHAVRLSVQRRRHETWKEFCNKLATQDFAKTTATMKHIKSHRQTSPVFVDPGGPQVAANKMADHLQQIFSGQFLPARRPPDQTVMISSPIAIDESCPFTHLSVESAILKLPTRKAPGVDHLRAEMLHPIVKQVSPVLCLLFQLCWQWAKGTIDPSLLISRNCVSAINSMRALQSLGVNHTGLSRLLSIRLYRQFIRPQFEYGLAISCFNIKQVAVFEKAQNTCLHVIFGGHSTSSTSVFHHLGNLPSMRERILTLGFKFVYCAFWLPDEALFTLLRPVLTNPAHQWFKVLANPIWLSLSNRQNADSKACKHAIHSFLNQGLSLQRSQQILLSACHPSLGVDPILWLPMTNYERSRFIRWRMGWLPGRSQPCSCGLHTTSHHHVIECTGAAIRLHLYSTVQPNPIDYVLNMLPLKKLKNNKNNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162X1M4</accession>
    <name>A0A162X1M4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">No apical meristem-associated C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_169913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290045.1">
        <property type="nucleotide sequence ID" value="XM_018436207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162X1M4"/>
    <dbReference type="GeneID" id="28997113"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169913"/>
    <dbReference type="InParanoid" id="A0A162X1M4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029466">
        <property type="entry name" value="NAM-associated_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14303">
        <property type="entry name" value="NAM-associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="No apical meristem-associated C-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD72005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="175" mass="20073" checksum="E843249EEEF28C44" modified="2016-07-06" version="1">MYFAETGTNFNLVHCYNILSKHLKWEARKPKLKVSHKKQFGKGKVVSSALATVGGAKDEEEDGEEEEEEKEEEEAGSRPIGRKQVKTQVAEQKMQEKQLKKALSVQAEMMKKGKRSLQRVEDLRVLFMNPLSIENPRDRQMIMDQQLKIRERGIWDEPAINNNDSSSDVVVLDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162X231</accession>
    <name>A0A162X231_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_79223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290135.1">
        <property type="nucleotide sequence ID" value="XM_018443443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162X231"/>
    <dbReference type="GeneID" id="29004348"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_79223"/>
    <dbReference type="InParanoid" id="A0A162X231"/>
    <dbReference type="OrthoDB" id="2351770at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD72095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="430" mass="49159" checksum="EEBE258D47F8ED40" modified="2016-07-06" version="1">MNTLTIDSEKADAIIGLVSTGRVAGEAKSHSPSDARKIALQALQNIQHTVKARQKKMLAYDITADCLDRHYKAKIYAARQKLTNLEVNLAGLTHALAILQQTRRVSEREVTEHEEVLEQARNYAQQRQNKKSKREQQYNHFYFVPLVSRQFENKYKRASDKNAFAEDQVCKIRSAIEECQATIRDTAKEQKLRQTEFEEETSKRDIIERDIRESENMLDHLAKGRQFWGEFDTCQAHILIECTKQMAALFGHSEKKSKSPKLQQERDEWISVFRLACLNYGECERQGEERWGSGLKAEFVCARCNVLKVEWPTPDKVRPNDLLCAECYEETRTSMIMEKKVNSLGGKLGLERPPNVRMASKASFMSSVSTNTNNSGRSQSSFLAESKPAVKKMLKTLFHKKSQALCNDSLQNGQSMNGYSNNSQHQSMMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XI68</accession>
    <name>A0A162XI68_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_181034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293085.1">
        <property type="nucleotide sequence ID" value="XM_018438404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XI68"/>
    <dbReference type="STRING" id="763407.A0A162XI68"/>
    <dbReference type="GeneID" id="28999310"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_181034"/>
    <dbReference type="InParanoid" id="A0A162XI68"/>
    <dbReference type="OrthoDB" id="2507140at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007841011" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD75045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="20109" checksum="AA543539E92A8493" modified="2016-07-06" version="1">MKLTAVSLLVPILAYLETASAQTDAGCAASVIFNQCLRNQDIYIKTCSGQDYTCLCKWHTTKLSCWDNCQNDVSRGSQEGLKTTFCSIAAPINATVSSIGSALPTASQAPSSSSNGSGSKSGNVASLSPSAAGPIKIPSAATAAGSLPSLGSTKNSNGTTGTNGGGGNVNKTSHSGAMSLESGPVFGVIVAVTCYWFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XKZ0</accession>
    <name>A0A162XKZ0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_166752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293555.1">
        <property type="nucleotide sequence ID" value="XM_018435473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XKZ0"/>
    <dbReference type="STRING" id="763407.A0A162XKZ0"/>
    <dbReference type="GeneID" id="28996379"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166752"/>
    <dbReference type="InParanoid" id="A0A162XKZ0"/>
    <dbReference type="OrthoDB" id="2283106at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="378"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD75515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="573" mass="62506" checksum="8C2FBFC533A1C4A0" modified="2016-07-06" version="1">MSTLLPSSVMQGMSPNLASFLGNMQAQFMSLQQCTNELESLAATNARLTAQLVNAEKLIADLRSQLASQSNCQIITNASTSSAPTTPKEPGIETSTWTTTAAAAHNSVVVPTALSVHKTPRPPSVRRVAASARMFAIPTGPKGYQYVYIPRSCRLTHREVRNSLKTLGVDTGHILDINFLAKDVVGILVHNQYAEKFQTTLTTVAIEILDAFDPLDPKNIADPKYKSLSDSELEEVAAELHSDRCLKALKYLCPHVAVPVGHFFCDQGWISKEDIPVHSVSGPGAGLWNANGLQPRAIYDVLQHCHSLHMLFITETWLLPPSHLPTSWSQIHLYGSPVAGNYRGSMGVSVLISPSCPYSVPQIPMSSNYALAIKIGSLRIVCLYVPPSMSTHDALAVLSSIPLTNDTIICGDFNSRLGSLTSDYATNTRGLALCQWLEERALTVISSIIDLFITNMSLTNATLNIHTGLSLNSDHRLLSLSFTYAINPTSHAPPPSRKTWNLSRLQEPDVLKLYAHTFVTNSTNLKSTLQSTFEHPPSSRLPIDALTDEFNSLIYNSLSSSIGNRPPRPSLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XLI7</accession>
    <name>A0A162XLI7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_166799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293605.1">
        <property type="nucleotide sequence ID" value="XM_018435492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XLI7"/>
    <dbReference type="GeneID" id="28996398"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166799"/>
    <dbReference type="InParanoid" id="A0A162XLI7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="216" mass="24427" checksum="573889520F2A9FC2" modified="2016-07-06" version="1">MLETAYARLEARFEARFEGSEATTEQPVRGNPPDVNHLQPVIGGNTIPHPSPQGQPNSWVLSAGSVTAALVLHFIRGNTKEAQLLYSAIGRLARQLVQLYYRGVVLHLTRETSWLETLRREQPVEILLLIGLRIPGCLSLCFLRDGKLLSPVEDSNKTNVFLDVINPTTKCLDHHKHNKLLFLISLVKFLSEFHFRSGLFFKCYNTVKIGQTHWES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XSU8</accession>
    <name>A0A162XSU8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PDZ GRASP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_180630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294375.1">
        <property type="nucleotide sequence ID" value="XM_018438342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XSU8"/>
    <dbReference type="FunCoup" id="A0A162XSU8">
        <property type="interactions" value="266"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162XSU8"/>
    <dbReference type="GeneID" id="28999248"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_180630"/>
    <dbReference type="InParanoid" id="A0A162XSU8"/>
    <dbReference type="OrthoDB" id="3318at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000026">
        <property type="entry name" value="Golgi reassembly stacking protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007583">
        <property type="entry name" value="GRASP55_65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024958">
        <property type="entry name" value="GRASP_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893">
        <property type="entry name" value="GOLGI REASSEMBLY STACKING PROTEIN GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893:SF0">
        <property type="entry name" value="GRASP65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04495">
        <property type="entry name" value="GRASP55_65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51865">
        <property type="entry name" value="PDZ_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ GRASP-type" evidence="7">
        <location>
            <begin position="108"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ GRASP-type" evidence="7">
        <location>
            <begin position="210"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="353"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR607583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD76335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="438" mass="49512" checksum="147EDDB100472B00" modified="2016-07-06" version="1">MDGSEVMHRLWNRDLAAVLNFRHILNNLRYDGTIPVSFTRVIRIGRIRRQAEEDLQEGRRPTQATAEWLRNSPVLRSRDLCRNQRFKFDPNVCLSTMGGAQSSENGHHGFHVLKVKKDSPAFQAGIEQFFDYIISIQGTSLEDGNSKELVRILQENENKPVVMGIYSSKNQAVRDITLTPTKDWPSEDPNEKSLIGCSIRYCSYERAGENVWHVLDIAPNSPAEMAGIIAHSDYIIGSPHMALKNEEDFYQLVEEFVNKPLRLYLYNTEWDSCREVIIVPSHEWGGAGSLGCDVGYGLLHRIPRRHSELTANGTEDGQQTAERYSREGVTNYSNAIFSSPDDELESPVLVHHHNHNHDHDHDHDHSHDHNHKHNHHNQESTSVILKAPPITTTDPIVITSDPDSTQLSKHLNDAVSSMTSSSIEPPSANTESKNDSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y0X8</accession>
    <name>A0A162Y0X8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cytochrome-b5 reductase</fullName>
            <ecNumber evidence="4">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_108290</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295745.1">
        <property type="nucleotide sequence ID" value="XM_018428038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y0X8"/>
    <dbReference type="STRING" id="763407.A0A162Y0X8"/>
    <dbReference type="GeneID" id="28988944"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_108290"/>
    <dbReference type="InParanoid" id="A0A162Y0X8"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF171">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0274">FAD</keyword>
    <keyword evidence="5 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="13">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD77705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="251" mass="27721" checksum="1E0881493A4C7DD0" modified="2016-07-06" version="1" fragment="single">LENIEKINHNTSLFRFALPEAEQHAGLPVASCVITRYPITKKDGSTGYVIRPYTPTSPEEARGYVDFIVKSYPDGKMSKHIHNLKVGETLDVKGPIPKYNWEGSTIQNVGMIAGGTGITPMLQIIRKVFSDKSTDDKTKVTLVFANQTEDDILLKDELDKYAAQYPNRFKVVYVLDKPQQANWEGVKGFVTPELIKEHLPTPETESSIVFVCGPDPMVAALAGPKAKDKSQGEVSGVLKALGYGSENVYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y801</accession>
    <name>A0A162Y801_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_62356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296925.1">
        <property type="nucleotide sequence ID" value="XM_018440956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y801"/>
    <dbReference type="GeneID" id="29001862"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_62356"/>
    <dbReference type="InParanoid" id="A0A162Y801"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="124" mass="14446" checksum="3FC13AEFF8D6A7B9" modified="2016-07-06" version="1">MRVFYICVSITFKRGYLNRVFFIGSIFDHMKVYEVDTIRIATLGVIDVVGVLGYCYQFLWGTNPERRFLRYSKLVCAFLVQRNKPAQQMLRRMITSDSLLEKYAPVADGKMNPRVSKRCSPSNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y8D8</accession>
    <name>A0A162Y8D8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_101010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296995.1">
        <property type="nucleotide sequence ID" value="XM_018427617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y8D8"/>
    <dbReference type="FunCoup" id="A0A162Y8D8">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162Y8D8"/>
    <dbReference type="GeneID" id="28988523"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_101010"/>
    <dbReference type="InParanoid" id="A0A162Y8D8"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD78955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="188" mass="21679" checksum="CED199A361D21410" modified="2016-07-06" version="1" fragment="single">REQRTVREMAIMHLLRHPNICQLKEWVSEGDQYYMFLEYVDGGQLLDYIINHGKLREKQARKFSRQIISALDYCHRNSIVHRDLKIENILITRDEDIKIIDFGLSNLYSPSSQLSTFCGSLYFAAPELLQARQYTGPEVDVWSFGVVLYVLVCGRVPFDDTSLPALHAKIKSGIVDDYPDHLSKGTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y9D7</accession>
    <name>A0A162Y9D7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="8">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHYBLDRAFT_106839</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="8"/>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297195.1">
        <property type="nucleotide sequence ID" value="XM_018427963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y9D7"/>
    <dbReference type="STRING" id="763407.A0A162Y9D7"/>
    <dbReference type="GeneID" id="28988869"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_106839"/>
    <dbReference type="InParanoid" id="A0A162Y9D7"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000341">
        <property type="entry name" value="MAP kinase kinase PBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000432">
        <property type="entry name" value="mitogen-activated protein kinase kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF25">
        <property type="entry name" value="MAP KINASE KINASE PBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="4"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAD79155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="292" mass="32872" checksum="4670B20AAFA155D3" modified="2016-07-06" version="1">MDDLKLQEELGKGQYGTVQKVSHQVTNVVMAMKEIRLELDETKLHQILMELDILHKSTSDYIVEFYGAFFIESCVYYCMEYMDAGSLDKLYGDGVPEDVLSKITHSMVKGLRFLKDDLSIIHRDVKPTNVLVNLAGQVKLCDFGVSGQLDKSLAKTNIGCQSYMAPERIKAANTYTVSSDVWSLGLSLVEMAGGKYPYTYDNMFAQLKAIVDEEPPTLPEEFTPDAKDFISACLRKDPQKRPTYGELLEHPFITKYQDVDVDMAAWAQQALATRKARDLEARQKSVAKPNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZGQ0</accession>
    <name>A0A162ZGQ0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_175139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441002">
        <property type="protein sequence ID" value="OAD66591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284631.1">
        <property type="nucleotide sequence ID" value="XM_018437420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZGQ0"/>
    <dbReference type="STRING" id="763407.A0A162ZGQ0"/>
    <dbReference type="GeneID" id="28998326"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175139"/>
    <dbReference type="InParanoid" id="A0A162ZGQ0"/>
    <dbReference type="OrthoDB" id="411871at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="562" mass="63633" checksum="6840D4FEE4B5073B" modified="2016-07-06" version="1">MPPPLCKSWNLSRLNEPDVHALYAHIFTQNSTSLLSTLQDIVQNPPLTRPNIDAITDEFNLLIYDSLNSSIGHRPSRPNHWKSFWNVALQTAADHRNQCYKKWRLAIGIDKVVWWTKHKHAQAEFRSQVQQAKRQSWHVFCQSMERDFSKATSKIKQLKRRRQPQHTFQHDDGPAVAAATMCDYLATVYSGHILPATRPPAPMTTCNSVPFASDDSPFTSPIVEEFMQFMPNCKAPGPDHIRAEMLKPFAGNGHMFQSIATHRRSGTLATMATLNSVGACRSGFSLLLSSRLYKTFVRPKFEYGLAISTLLKQDIKVLESIQDKCLRMIVGGHATSSTIVLKHICNLPSMKFRADALMAKFCIRSRFSPAQCLLSLLHRHHTVYSSLVSLGKTHLLSNLPPTLKLRSPSAVKNHFESIREAGFATFLQSNTQVLIQACRPVLGVDPILFLPASRVERSRLIRWRMGWLPGKPKECPCGSDHTSRRHLLDCPLVPMALFEQLPQPDQDQIHRIDFAITSLPLSSQEPRPAYWIPLLTILWHIDVICNPDGDYSHETEHGALWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZM02</accession>
    <name>A0A162ZM02_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CCHC-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_151248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285761.1">
        <property type="nucleotide sequence ID" value="XM_018432634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZM02"/>
    <dbReference type="GeneID" id="28993540"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151248"/>
    <dbReference type="InParanoid" id="A0A162ZM02"/>
    <dbReference type="OrthoDB" id="2213868at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD67721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="279" mass="31134" checksum="AF7794A3C9017A86" modified="2016-07-06" version="1">MASSAIQPDTPPTGKHLINSHTNNSPTITTLTPGLPLTYLTALTNTALTFCHAIVLGSNDPLTKSHTWRESTSQFSVYYTTPLETSPKFIVFFDALLQSFLPGEIFGLNPSNKAGTLFELHLSSKDLTLSKLPRLPSQEYTTLDTKLRNALTKYGYVHDISINTLFGFMDGSGHAYMERPPYEEGALLPLRFKMDFDDNTMFLATWLNMGAHCALCQTMGHDRDNCPNQLKETHSCYGCHQVGHFRSKCPHAAKVNNSYKWDCKVPEPHGPHRTTATHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZNL7</accession>
    <name>A0A162ZNL7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_150734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286101.1">
        <property type="nucleotide sequence ID" value="XM_018432541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZNL7"/>
    <dbReference type="GeneID" id="28993447"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150734"/>
    <dbReference type="InParanoid" id="A0A162ZNL7"/>
    <dbReference type="OrthoDB" id="2255066at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="320" mass="36581" checksum="04AD7158D1247CFA" modified="2016-07-06" version="1">MPAKMSQFVAQDQIRVFDTEQQFTICGPVVLPKEGEVDAWGEIDEHTKCGDVLYCRFTITVASTTQKPTHFLDTFYAEAYEKLFFPEFFITEQPRNWNAIAYLLQFVQKNPTIPTRSGNKALAQDTKIMQAYVISGTIADTMLRQMDNALKSAKGKSAIKEFWKNSASIASTSISYETSKYRLHGQMAEEIVNNDDTENTPNSGEEKEDEKEDNKEIDDIWESWKMLLKTIRRSTVLSALSKQVLRRPVLPVIFFRELNNQVLNITMQLVDCALKPVLYDALNTSRAWAIAILAGQPGQPGNILRHFSHEFRQMTQIYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZQF0</accession>
    <name>A0A162ZQF0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_5487</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286411.1">
        <property type="nucleotide sequence ID" value="XM_018440194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZQF0"/>
    <dbReference type="STRING" id="763407.A0A162ZQF0"/>
    <dbReference type="GeneID" id="29001100"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_5487"/>
    <dbReference type="InParanoid" id="A0A162ZQF0"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF488">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="80"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD68371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="142" mass="16617" checksum="8E16CC9941EC3A5F" modified="2016-07-06" version="1" fragment="single">LLQIFFMFLTVSSFALFYYFAVPHVPGPYLGRIHQFLIPAHIGVLYYSYYMACTADPGIITANNHQSYMDHYKYDNLLYEPKECTTCKRLKPARSKHCSMCHACVGRSDHHCAWINRCVGVNNHRYFFFFLYSLIQLCVYGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZSJ6</accession>
    <name>A0A162ZSJ6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_63313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286821.1">
        <property type="nucleotide sequence ID" value="XM_018441107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZSJ6"/>
    <dbReference type="GeneID" id="29002013"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63313"/>
    <dbReference type="InParanoid" id="A0A162ZSJ6"/>
    <dbReference type="OrthoDB" id="2389915at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="556" mass="62479" checksum="E5CA42BEC4728684" modified="2016-07-06" version="1">MTNRAELLANGKVSQTVSLPDQSQFISAMIPNLAFGENINTSSNEDIDIIDSTEDDKPMYDVGEECENDIDEIEDTTPLLGFDFSQPLPVLSNNEKKNLAFMQLIQEFGISCQAHKKIVEHFNQIFNCSINITYQACSPHLENKLLEHFLGIKADGYNICIRDCMQFNNKNDIACVKCGEARYRNGQTSKSDTRVPVRSIVQLPLARQLALCLADDKTRAEMLYHHNHQSSQDGQKADIFNGHVYQSMKHLFSGENNIAISLSIDGFNSHNVSGSVTIIHATVLNLSPTIHYEKNRMIQIAMLPGRTGPRDIWFFLEPMLRDPCLLQTEGIEVKTLTMTIRAKMHVLMATGDILALAKLACHVDHTMGQTPKHDQYFRMLLGTQTCSLESFRNYNLASSEDRKGLNGQLLLVVMETFSDPFFFVLDEIHGLCHGIDKQYGIKHPLYLSLATQREIGAAMVAAKSTIPTSLHGVWRDVTKNASFFRTVDWADFLLFVVPTLVAEHVLDSVTQKALLGLVQTCNLLMSWELSAENQTLMRSHHWKNRVISSGSNVPKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZW44</accession>
    <name>A0A162ZW44_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_149815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287461.1">
        <property type="nucleotide sequence ID" value="XM_018432341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZW44"/>
    <dbReference type="STRING" id="763407.A0A162ZW44"/>
    <dbReference type="GeneID" id="28993247"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149815"/>
    <dbReference type="InParanoid" id="A0A162ZW44"/>
    <dbReference type="OrthoDB" id="2283661at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="166" mass="19411" checksum="D5A77EB5F97E0925" modified="2016-07-06" version="1">MFLSDEDRSLVIWINEKLPSQNYCIFTAELSSFNLVLSSFAFGFQSLSQIALMTISKSVCLDATHGISVRSAEVLYSLVIWHPETGKGISIAYMITNDHTFLRSMLSQQHHLKQQSIFVSFMFFVLEFKQQIQQEQQFLNYFEQRWVGSDEVIRRWGRPYVTQQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZZQ0</accession>
    <name>A0A162ZZQ0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_71520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288121.1">
        <property type="nucleotide sequence ID" value="XM_018442489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZZQ0"/>
    <dbReference type="GeneID" id="29003395"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71520"/>
    <dbReference type="InParanoid" id="A0A162ZZQ0"/>
    <dbReference type="OrthoDB" id="2267841at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="267" mass="30737" checksum="2EE0DE4D3974525A" modified="2016-07-06" version="1">MAPIYQKTVRKQYGGYDFVSAKTFKHYQEKDILALKEMQETVIWETAEAVNYNEDMFEIEQQDIEVYFVFKNLNNIDCRLDTSTRNLSLSESDNVFGDEVNTFYVSDSLEDEEPEDEMTDNEMTNDENNSLKSISELNLIYQFIIISVAFFVTLYVVDEEAVILIAIVNKILQFLFDLFCLPVNIPGLKRLAGFNVLTNGIKKYIAYSKCHTIYENNNTSPICCTLPMFGKCSLCNNSLFKTGSGSRVPKKTFVFHLVKKALKTFFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AIV3</accession>
    <name>A0A163AIV3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_64730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291811.1">
        <property type="nucleotide sequence ID" value="XM_018441343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AIV3"/>
    <dbReference type="GeneID" id="29002249"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64730"/>
    <dbReference type="InParanoid" id="A0A163AIV3"/>
    <dbReference type="OrthoDB" id="10417613at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="322" mass="37378" checksum="4359C0FB2E9FCE3A" modified="2016-07-06" version="1">MVNIQSSLRRVFVYIWTMRLTRNNRVYSLRVKHVTNFLRELKDESSVVRKHKKSRLELLSSLAKETNYVTLLCDTSTIISFLTFKKKVEAIVFAWSVFVHLPPFIMSTLSAFGFIHRKPHRNTQAVKPDMMKGTTLSAIYCSSPEKPSKSIAQSNPTKSRTDLVHTTKSQSKNTINSITHYFTSSHHESMEIEEEEEEEPILKVRQSISCSTMWEAMINELDTIYSDHLLTVDPHPFLGCGQRRRHEEDNTMAIVHLHSDKRQRTQQALVEAFKHSMKLSNYRPIQMSTLECPEDRSRAMRRTLDINETDAFLSQIISELMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163D105</accession>
    <name>A0A163D105_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione gamma-glutamylcysteinyltransferase</fullName>
            <ecNumber evidence="1">2.3.2.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_188910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.2.15" evidence="1"/>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285980.1">
        <property type="nucleotide sequence ID" value="XM_018439582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163D105"/>
    <dbReference type="GeneID" id="29000488"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_188910"/>
    <dbReference type="InParanoid" id="A0A163D105"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016756">
        <property type="term" value="F:glutathione gamma-glutamylcysteinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046938">
        <property type="term" value="P:phytochelatin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.30:FF:000001">
        <property type="entry name" value="Glutathione gamma-glutamylcysteinyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.30">
        <property type="entry name" value="Phytochelatin synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040409">
        <property type="entry name" value="PCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007719">
        <property type="entry name" value="PCS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038156">
        <property type="entry name" value="PCS_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33447">
        <property type="entry name" value="GLUTATHIONE GAMMA-GLUTAMYLCYSTEINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05023">
        <property type="entry name" value="Phytochelatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51443">
        <property type="entry name" value="PCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0104">Cadmium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase C83" evidence="5">
        <location>
            <begin position="51"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD67940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="306" mass="33760" checksum="742511A7AC40EE62" modified="2016-07-06" version="1">MASRTFSFARHATKSISTHNINKFTRSWFPTTSQIHRQVTTVVNATNATYPPYLPLFAFVAPKPLVNLVDFTSTEGKRLFRGAMDQGQAESFFKLMGNFSTQSSPALAGVSSLAMALNALEIDPKRIWKGNWRWFSGDQLKTCSPKESVYKRGIPFDEFTCLAQTHCSVEPKRASVGGYNQFLVDLERVTSNPDSQMVVNYARSHLGQQGEGHFSPIGGHNTKDGMTLIMDVARVKYPSVWVDSRTLYESMLLQEESGGSRGYFVLTPGQQINSAASSSTGGGSAANRPLKCNQCSRLCSKKKRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163D7W7</accession>
    <name>A0A163D7W7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_188476</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287450.1">
        <property type="nucleotide sequence ID" value="XM_018439516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163D7W7"/>
    <dbReference type="STRING" id="763407.A0A163D7W7"/>
    <dbReference type="GeneID" id="29000422"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_188476"/>
    <dbReference type="InParanoid" id="A0A163D7W7"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015227">
        <property type="term" value="F:O-acyl-L-carnitine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902603">
        <property type="term" value="P:carnitine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF4">
        <property type="entry name" value="CONGESTED-LIKE TRACHEA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="21"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="118"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="217"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD69410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="32558" checksum="4D59A08BECC546F1" modified="2016-07-06" version="1">MAEVQQIPAPIALKETKASTVSSVKSFMSGGFGGMASVMVGQPFDLVKVRLQTSEGVYKNTADCFKKIIAKDGILGLYRGMATPLASVTPIFAVSFFSYDLGKKIMFSLKSDKESKELTLAEITAAGAFSAVPTTLFMAPSERVKVLLQIQGQGGEQKYKGPLDVVRQLYKEGGVRSIFRGTGATLLRDSPGSAAYFVAYELVKKALTPAGTRPEDLNPGAVLFAGGMAGVAMWTIAIPPDVLKSRLQSAPAGTYSGVVDCLQKTLKADGPRALFKGLGPAMLRAFPANAATFLGVEYSMKAMNLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163D8L5</accession>
    <name>A0A163D8L5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF962 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_21373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287590.1">
        <property type="nucleotide sequence ID" value="XM_018439758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163D8L5"/>
    <dbReference type="GeneID" id="29000664"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_21373"/>
    <dbReference type="InParanoid" id="A0A163D8L5"/>
    <dbReference type="OrthoDB" id="5511466at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34205:SF2">
        <property type="entry name" value="DUF962 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="13596" checksum="ACB9E2DF200339DA" modified="2016-07-06" version="1">MIRAVANPNYSSRSEPAGGFKSFEAFYPFYLGEHCNRINRRLHLIGTTISIIMFMIALLKRNKNYFLAGILQAYAWAWTGHFVFEKNKPATFRYPMWSLWGDFKMWSEIGMGKRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DF70</accession>
    <name>A0A163DF70_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_126259</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288870.1">
        <property type="nucleotide sequence ID" value="XM_018429092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DF70"/>
    <dbReference type="FunCoup" id="A0A163DF70">
        <property type="interactions" value="673"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163DF70"/>
    <dbReference type="GeneID" id="28989998"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_126259"/>
    <dbReference type="InParanoid" id="A0A163DF70"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000014">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005568">
        <property type="entry name" value="Ribosomal_uL6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03868">
        <property type="entry name" value="Ribosomal_L6e_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD70830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="235" mass="25210" checksum="E60B0FC2653B1442" modified="2016-07-06" version="1">MPHAPRNSFLVPGVAQFSRSTTFAKKALHKRQKKAVAAPAKKVVADKTVEVKGAKNGSKRTVPAKKADRFYPAEDVPQPKKSRKVSKIGALRATITPGTVVILLAGRHRGKRVVALKQLDSGLLLVTGPFKINGVPLRRVNQAYVLATSTKIDVSSVKLDAKINDAYFKKAAGAKAQGFLEGAEKKAAFPASKAADQKVVDKAIIDAAAKTPLLRQYLSSTFGLSKGQFPHAMQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DN25</accession>
    <name>A0A163DN25_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetratricopeptide repeat protein 39B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_169599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290510.1">
        <property type="nucleotide sequence ID" value="XM_018436113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DN25"/>
    <dbReference type="GeneID" id="28997019"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169599"/>
    <dbReference type="InParanoid" id="A0A163DN25"/>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="742"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="762" mass="84959" checksum="E60E00549FA14510" modified="2016-07-06" version="1">MTEADTTQPPPAVIDQTQKHQDAEEPTNDNTDPSHPSLLLATDARQRGLTTGEPASLVPPISSSPIPTSGHGSFSANDLERMNANAIFIKNELKAAGPTNLTLEEQEEQDKPVIEGLQLLLDNRFMSAKAAFSKKANVDPLHALALSSMAFLKAVMTSAEHDQTTALNALNITYDIAKTQRSFYKTPPAMTGYISRYYNFIGGSEEDTSADNKSQAAQKPKPKPKTSSIPPTSTSETAAEEEEKEEEENEKDKEAPAKDTTTSPTQTVATSEAFPPNGLLRAHVIEAECCLQIAILQLIQGSIIDYVKCGLNLRRAYSSYVFVWEEYTKMGPEHSKYMDANTVSCVQFGVGAVHLVLATLPVKVLKAVSVLGWKPDKQLGFGLLNACAEGNGVRAYMATMMLLSYYTTVTSFTPQILSSVYTKSAMETLLEAQRGHPNSALYLFFSGSVARLAIDLPLSTKSYLYASDMGKGDWAELAFTNTSRYEVALNHLITGNWDHAATAFGYLSKHHYWSAAFCKYAEGACLEMNGKRTEAILTFADVEALVDKKKGSSRMEYMDAYTLRKIATLQESGYQDMGMYCPILEFMFIWNLFHFMDHNLLKECISRVDDALEFIQLKEEQAYQERMIELAPDTDLPDYFDERAILLLIKASIKNVLGQTSDIAGHLNWIIDHRESFGSESWVVPYAFWESGVSCWNLDDKPRARRVWEMALTCSKYDFEYRLSVRLGLALTRAEELGFTTPIPEPEKNKRSKIQTKTFKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DNB4</accession>
    <name>A0A163DNB4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_169637</name>
        <name evidence="1" type="ORF">PHYBLDRAFT_172922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD69091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287131.1">
        <property type="nucleotide sequence ID" value="XM_018436893.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290550.1">
        <property type="nucleotide sequence ID" value="XM_018436121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DNB4"/>
    <dbReference type="GeneID" id="28997027"/>
    <dbReference type="GeneID" id="28997799"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169637"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172922"/>
    <dbReference type="OrthoDB" id="2262863at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF34">
        <property type="entry name" value="NOTOCHORD-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="764" mass="87181" checksum="A1C0F4F56D1E94CB" modified="2016-07-06" version="1">MPVFPSQRISVPGSNGNAFAHINLPSDHLRFLMANPKKSKLISSMPDRTPNQSICLEQGEKWRTHHLFQQPMHTVNGIDVWFGNIVYLKTNDCSIRFLVESFHTANKNIFARGYLVRAISIVCYGVEVAVTDFRVEQISHVDTTPVERDHYYSISSSLTRLSPAHDFLLFGVHPMKKPMPLSVLPGNVDRDAVFYKVRIVSIILFTNDTSGNRSKQYNPFESWLMRCAALPFKDRNSIANIQFLSTIPKKDGANGMSLLPAIVDDFKKLEKGVKMFSAEDNEYVLVVAPILWIEADTPCHSELCGLLGPATTFPCRRCYIELRRAKVFVKDLFYFCECHERRTREHYVLANSSPGRDTEIPNAPKIGMNTPANKISFRDRSTGRLLELQSFDPEKDTPVEILHTILLGVAKYMVIDLVKVVLKNDTATIARLSEFLTDYTRSTGLSRKFTRNLRHSGSFLGRDFKVLLQILPVILITEFSGNHELDLIIPCFVELGRLCSLVFVRQVTSDFDNYIIRVDNAVKCLIRALFDYDKGTKNELHKAYCTKPKVYYLTHLKEDIIRFGPALNYETEKGEQFNKHIREHLFHTNRQNTSRDVCLKFAKQVALQHVIDGGSWINSSGNREKSGTGIERFIKDNNESLFYYTFFGGSRELKDNNDTGDIEDDAVQNNSFGAFVFKNDPISRPRIGLVSGSVVKFLSIVPRTDNDRNNNYAKAVMTGEHSDVANMNLVCKLDLHIFRNPFYIVNLSKFGSYWFIFNNILFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DVK7</accession>
    <name>A0A163DVK7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_145166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291730.1">
        <property type="nucleotide sequence ID" value="XM_018431380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DVK7"/>
    <dbReference type="GeneID" id="28992286"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145166"/>
    <dbReference type="InParanoid" id="A0A163DVK7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="382" mass="43403" checksum="8168795745D069EE" modified="2016-07-06" version="1">MIATSPCVRTQTMRTHACPDIRSYFEMAKPKFICTKGYASMTDQLVSPSRWVGQKAHEESRLGYGYNKNKFLIIIRDYWLRTAKKVFEMTGFILWAENTSKEQVEAASSKQQSSRRKKYFFVRDNINHWSVHPEDKYYLYTTCLEDTRESLGALDFTKRQSCSGSWRGKPRSGSSSAIWWPNPFVVDPIAASWHIVSAGSLVVYCWWSRIPPAGGQGPFRPVIEEHFAVPGPSLQMMLPIPSQVPFLTKQILSIKPYSALSTPIMRQIQKPESCARMTAARTKIPEMVKPRFAFMSKSNSESCPSQSPNVQNYPSVVWVVPPSLKTKSISKKGSNAKFQKQVPKEKSKTKTEAYTKSCKKKQAYTKSSSPKGSKEIRTRGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DY65</accession>
    <name>A0A163DY65_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_144595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292180.1">
        <property type="nucleotide sequence ID" value="XM_018431248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DY65"/>
    <dbReference type="STRING" id="763407.A0A163DY65"/>
    <dbReference type="GeneID" id="28992154"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144595"/>
    <dbReference type="InParanoid" id="A0A163DY65"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="286" mass="32985" checksum="B45C020F545590FD" modified="2016-07-06" version="1">MAPPSLSIVERIKRDHFTNSFASQSLINEIKQLQSDHDWEADLILQEIRDIYDDPSHPLYDFGFELFTTNNQFIKKLLSTLSNTTEGQTIKGSTGLSTILPSEREELIQKVEDGILRKYSNVESFVMGDKLGPVSETRHRLGVAAVDAESLRSTVEKIKNGLQQRRFDMPLGRIKLTRLVVECIELMLEVLDTTWSIMEEFRLKHEKEMNTVYDEHLGVMVDTLESLRNALEKQHQDVQAELSFANKQIEEYHSMGPEFRTLCSAYFDLLTMIQETEDDIRRINNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163E295</accession>
    <name>A0A163E295_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_61198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292790.1">
        <property type="nucleotide sequence ID" value="XM_018440769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163E295"/>
    <dbReference type="GeneID" id="29001675"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61198"/>
    <dbReference type="InParanoid" id="A0A163E295"/>
    <dbReference type="OrthoDB" id="10473265at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD74750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="233" mass="26446" checksum="8C41F16F880FA02A" modified="2016-07-06" version="1">MPSDNTRLPRHLFRKNAKLNKRKQRRIAEATERNQNTACVEETPEEHSLYLQQQRQWEERERRENRIQMARQKAQELEQKAKANAEQKWKDALLRIPLLPPAFPSTTVPSTAESKLNMGHVPQFISSKDENPPKRRRYKDIQRERNAAAAAANKNNNTTATNTTSTSTITATASATATATTTTTLTIPTETTNSTMITIEESKEAAPVALPRTLIIDDDDDSLEFQGNTRHWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EC60</accession>
    <name>A0A163EC60_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHYBLDRAFT_180036</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295930.1">
        <property type="nucleotide sequence ID" value="XM_018438255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EC60"/>
    <dbReference type="FunCoup" id="A0A163EC60">
        <property type="interactions" value="230"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163EC60"/>
    <dbReference type="GeneID" id="28999161"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_180036"/>
    <dbReference type="InParanoid" id="A0A163EC60"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041672">
        <property type="entry name" value="Bap31/Bap29_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18035">
        <property type="entry name" value="Bap31_Bap29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="13">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Bap31/Bap29 cytoplasmic coiled-coil" evidence="14">
        <location>
            <begin position="170"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="165"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAD77890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="228" mass="26829" checksum="4436EADF682053C1" modified="2016-07-06" version="1">MPIYYSLTFGILLTEMIAFGILVTPLPTRWRRAMMKFASTSPVIANGLYGLKIVFAFIFVLFLDTLNRLHRIESEVSDEHKHDYNYEANLKAKRFYAQRNIYLTGFTLFLSLILERTSKLVLDMLKREEELDNAKKEAISLLPFSYIFTQSAVTMKDQQRLIDLESTYTKQVNELTKEIKELKTKELDIETLKKQVEQQSVEYNRLSDERNEFEKKANLMTLETRKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ESQ6</accession>
    <name>A0A163ESQ6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_120868</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299370.1">
        <property type="nucleotide sequence ID" value="XM_018428764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ESQ6"/>
    <dbReference type="STRING" id="763407.A0A163ESQ6"/>
    <dbReference type="GeneID" id="28989670"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_120868"/>
    <dbReference type="InParanoid" id="A0A163ESQ6"/>
    <dbReference type="OrthoDB" id="10254973at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="5">
        <location>
            <begin position="2"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD81330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="280" mass="30968" checksum="31EAEE33AED14612" modified="2016-07-06" version="1" fragment="single">MIIGPNGTGKSTIVCAIALGLGGAPSLLGRAKNAIEFIKTGATESMILIELKNGNGPNVTVQRNIHKAGNQNTWKLNSKPSTQKEVISTIAKFDIQVDNLCQFLPQDKVAEFAQLSPPLLLKRTQLAAGEKKLSEWQDQLMTWRLTQKDLTLSYESGQTHLKVLTDRNVGLEKDVLKLKQREAALKRVAILKATLPLAKYSSAKIRHDEAKIEEEEKKRVVQQIEQSHLPIQEAVSTLETESRNAVTTLNQLKQTATGMSSQLTDTTHQIERSKLVTKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EST5</accession>
    <name>A0A163EST5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_138896</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299390.1">
        <property type="nucleotide sequence ID" value="XM_018430101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EST5"/>
    <dbReference type="FunCoup" id="A0A163EST5">
        <property type="interactions" value="606"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163EST5"/>
    <dbReference type="GeneID" id="28991007"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138896"/>
    <dbReference type="InParanoid" id="A0A163EST5"/>
    <dbReference type="OrthoDB" id="1688503at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000009">
        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD81350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="134" mass="15165" checksum="3D1789193CD2FA09" modified="2016-07-06" version="1">MKFSADVSSDRSKSRKAHFTAPSSIRRKIMSAPLSKELREKHSARSIPVRKDDEVMVVRGTYKGREGKIVQVYRKKWVIHIDRVTREKVNGATVPIGIHPSKVVVTNLKIDKSRQAILDRKNSAAKKTAMQEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167J3T3</accession>
    <name>A0A167J3T3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_155746</name>
        <name evidence="2" type="ORF">PHYBLDRAFT_156837</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441036">
        <property type="protein sequence ID" value="OAD65069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283109.1">
        <property type="nucleotide sequence ID" value="XM_018433521.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289578.1">
        <property type="nucleotide sequence ID" value="XM_018433434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167J3T3"/>
    <dbReference type="GeneID" id="28994340"/>
    <dbReference type="GeneID" id="28994427"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_155746"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_156837"/>
    <dbReference type="OrthoDB" id="3909530at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD71538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="109" mass="12406" checksum="57499A4205B1B615" modified="2016-07-06" version="1">MLKQACSLEYQLVDYVSVARVRPRTSKGITDLLLPNFILLSAGSFSKKTEKPKLNPTKKLVCLFSKIRSRSLSELTRQITPRTKNGHAPPPIKSRKSFQSVNPSYVWTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JCP5</accession>
    <name>A0A167JCP5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_184091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441008">
        <property type="protein sequence ID" value="OAD65728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283768.1">
        <property type="nucleotide sequence ID" value="XM_018438879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JCP5"/>
    <dbReference type="STRING" id="763407.A0A167JCP5"/>
    <dbReference type="GeneID" id="28999785"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_184091"/>
    <dbReference type="InParanoid" id="A0A167JCP5"/>
    <dbReference type="OrthoDB" id="2279208at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="449" mass="49836" checksum="7AE6E8E113205849" modified="2016-07-06" version="1">MTSERGRPDRQLRQPDSSRDKLMRLKRLSPQEELRAMAEATAAVIRVRRREPESMLIWGDRRKAVIKRFPDGGVEIIVPQNLTPEQEQYEFPPRSQFLKQLSTAEKRKMSAQTEPTPPSSSTSSSSGSSVMTVPFQQSQSVDLDQATISEWLNAQQKEKAERQQIVPILLTPSTSKRSKRNPLPPKPSPKCVQPVRTQTDQQSPEWLPDGTLHLQSQAGKRWTTPAEPPPQPAPSKHYVSKKLLISARTIIPPPSRQSITSPRTQPVNVRTSRAPSITSPRVQPFNSCARPITSPRVQPATSRTPSITSPRVQPFNSRPPPLTSPRISAITVRTSPPVPTPRLRPRQPSDAKPTPKPSTPTPLSSMVERTQSAKKTIVHQHMRISERGNHLARLQQQQQAVTATATATATATATTTTKINESQDLCTKKDASFSSGYLAKDMYIMKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JQD7</accession>
    <name>A0A167JQD7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="2">6.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHYBLDRAFT_189260</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="2"/>
    <dbReference type="EMBL" id="KV441002">
        <property type="protein sequence ID" value="OAD66498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284538.1">
        <property type="nucleotide sequence ID" value="XM_018439629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JQD7"/>
    <dbReference type="FunCoup" id="A0A167JQD7">
        <property type="interactions" value="562"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167JQD7"/>
    <dbReference type="GeneID" id="29000535"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_189260"/>
    <dbReference type="InParanoid" id="A0A167JQD7"/>
    <dbReference type="OrthoDB" id="409189at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000031">
        <property type="entry name" value="Asparagine synthase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000050">
        <property type="entry name" value="Asparagine synthetase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006949">
        <property type="entry name" value="PRK09431.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF2">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="6 10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="15">
        <location>
            <begin position="2"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="11">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="360"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="13">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAD66498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="569" mass="64105" checksum="11E770FFEEC6997F" modified="2016-07-06" version="1">MCGIFAVHNYQGDLEAYRQRALYLSKKVRHRGPDWSGCFCANNSIFCHERLAIVGVDSGAQPLISEDQNIVLTVNGEIYNHKQLRHELKDKHTFMTHSDCEVIMHMYKEKDTELVHHLDGMYAFVLLDVKRNRVIAARDPIGITTLYYGWNSKMPGTTYFASELKSLNEDCDKILAFPPGHIYDSETGKTTRYFNPTWWPEGRMTTNPVDYSVLRESLEKAVRKRLMAEVPYGVLLSGGLDSSLIAAIAARETEKIAAGGVSAENGDDSYDESGPALWPRLHSFSVGLPGSPDLVAAREVAKYLNTIHHEFTFTIQEALDAVSDVIYHLETYDVTTIRASTPMYLLSRKVKAMGVKMVLSGEGADEIFGGYLYFHQAPDAASFQAETVTRVKNLHTSDCLRANKSTLAWGLEARVPFLDKAFLETAMNIRPEDKMPNRAEGRAEKYILRKAFDTSDDPSAKPYLPHNILWRQKEQFSDGVGYGWIDALKETSLTKVSDEEFAGASARWSKDTPTTKEAYMYRVLFEQWFPQEACTASVVRWIPRADWGCPEDPSGRAQKAHEAAYADKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K1L3</accession>
    <name>A0A167K1L3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_67216</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441025">
        <property type="protein sequence ID" value="OAD67076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285116.1">
        <property type="nucleotide sequence ID" value="XM_018441756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K1L3"/>
    <dbReference type="GeneID" id="29002662"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_67216"/>
    <dbReference type="InParanoid" id="A0A167K1L3"/>
    <dbReference type="OrthoDB" id="3561125at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD67076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="351" mass="39483" checksum="3E51A53505A09973" modified="2016-07-06" version="1">MSITQSVNTISGVPLVLSPHCGDLLKCSCNYCLQFESLDVNIDSSFSQGQPMEELLAAGSELLHSCLTPTYAFNVKAPNMGGYHCDTFLSENANVPIQDQHLALAQNNITPPCCSLSILQDDFMPTQTDVNKASSVPDENNLLFQTFLKQFLEEDPCLFNLVDNPASQGSWPIENISQEVYPGTYQPQPFFVTQQQQYTDSPEPFTPGLSTCLSQYDSPMLTDRSTIMSMNGSPNTMFMPFYELKSNFDYASNTGEENTDWLHRLLRDPVTNTSSGTKNQRNKRGRKGVKSSDKIKKHICCFCSYSTDRVSNFIRHVESHTRCVNEWECKPCAISFSSKSNLARHNRRTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K5L7</accession>
    <name>A0A167K5L7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mitochondrial inner membrane protease ATP23</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_174369</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Has a dual role in the assembly of mitochondrial ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
            <topology evidence="1 8">Peripheral membrane protein</topology>
            <orientation evidence="1 8">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M76 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285368.1">
        <property type="nucleotide sequence ID" value="XM_018437237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K5L7"/>
    <dbReference type="STRING" id="763407.A0A167K5L7"/>
    <dbReference type="GeneID" id="28998143"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174369"/>
    <dbReference type="InParanoid" id="A0A167K5L7"/>
    <dbReference type="OrthoDB" id="285308at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019165">
        <property type="entry name" value="Peptidase_M76_ATP23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711:SF0">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE ATP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09768">
        <property type="entry name" value="Peptidase_M76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 8" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD67328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="175" mass="19719" checksum="7F0C97761A9BD723" modified="2016-07-06" version="1">MIAMNSMSEKQCTRELGRILESSSKVAVLLRAIQLLDKTALKRGVTCRPCKATLQENRVGYYDFQYKRVVLCCENIHTRADVEETLIHELVHAFDRARKGKFSSMCHLMACGEVRASALGQCADVTPESRKKECILRDAIRSTREHCGDEAERIVRQVYNKCVKDVAPFVVGVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KC68</accession>
    <name>A0A167KC68_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_151261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285776.1">
        <property type="nucleotide sequence ID" value="XM_018432642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KC68"/>
    <dbReference type="GeneID" id="28993548"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151261"/>
    <dbReference type="InParanoid" id="A0A167KC68"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="179" mass="20514" checksum="95A7EAEA08A0C91E" modified="2016-07-06" version="1">MRCGPMTATQRQQRKIEMSAEAVPAYMHANMIIRPSKAMSLNATLDCGDPDTQMYMKPYKHMHLLHIHMSGFAFLSVAPANNVLPITISGEQFVYDNTMSIDSTRESTEHEYAIEAFEYAKNCSLTTRHNEQDLYQLMQYATEEEAEIIRAAYAAPIKAFQEIKAKYEAHFRILNIQCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KDR8</accession>
    <name>A0A167KDR8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_68223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285896.1">
        <property type="nucleotide sequence ID" value="XM_018441913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KDR8"/>
    <dbReference type="GeneID" id="29002819"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_68223"/>
    <dbReference type="InParanoid" id="A0A167KDR8"/>
    <dbReference type="OrthoDB" id="5559077at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006750">
        <property type="entry name" value="YdcZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34821">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YDCZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34821:SF2">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YDCZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04657">
        <property type="entry name" value="DMT_YdcZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="16476" checksum="D42F3A010DEFD1D5" modified="2016-07-06" version="1">MVDLLSNSVFTSVLLVTGGCTIALQAGCNGTLNRYIGRSASSVWSFTTGVLGCLVFFAIDVTRLGTPLPSESLRGAPGYAWIGGILGAYYVITNILTVRRLGAATTLSIFVCSLVIMACIIDNWGLLGVEVRKYSIARIFASLGLVLFVAIITRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KGR2</accession>
    <name>A0A167KGR2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cysteine-rich transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_160215</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CYSTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286096.1">
        <property type="nucleotide sequence ID" value="XM_018434139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KGR2"/>
    <dbReference type="STRING" id="763407.A0A167KGR2"/>
    <dbReference type="GeneID" id="28995045"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160215"/>
    <dbReference type="InParanoid" id="A0A167KGR2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028144">
        <property type="entry name" value="CYSTM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12734">
        <property type="entry name" value="CYSTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cysteine-rich transmembrane" evidence="5">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD68056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="88" mass="9241" checksum="76BDF3A864E382A4" modified="2016-07-06" version="1" fragment="single">MSSNYQYPPPPQGQYYAPPQGGEYGAPPPGAYGAPPPGAYGAPQGGYQPAPPPQTVYIQQQPQKQDDSSCCWGCLAGLCICCALEEMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KQ37</accession>
    <name>A0A167KQ37_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_97808</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286659.1">
        <property type="nucleotide sequence ID" value="XM_018444033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KQ37"/>
    <dbReference type="FunCoup" id="A0A167KQ37">
        <property type="interactions" value="774"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167KQ37"/>
    <dbReference type="GeneID" id="29004938"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_97808"/>
    <dbReference type="InParanoid" id="A0A167KQ37"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="8">
        <location>
            <begin position="59"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="110"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="317"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD68619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="352" mass="39406" checksum="3529FDFF13D2B00F" modified="2016-07-06" version="1" fragment="single">LSHNESIAAACGIVSTSSILQYQNVPPKNKNNNPVFETARGYLKVKPRRNIPEAPVKILDSPYMVDDYYLNLLGWSCHNVVAVALERSVYLWNAETGTANVLDEDPKHMVTSVSWSADGTLLAVGDETGETQIWDVYRSELLRSMGGPTCRVGVLAWNKCTVSSGAYNGVIYNHDVRIEKHNISEFKGHDEEVCGLEWRSDGEYIASGGNDNILNVWDPRQHRNSIMSRQEHKSAVKAIAWCPWNLPLLATGGGRDDKKIHFWDATKNTKLNTINAGSQITSLRWSHHYKEIVSTHGLPNNNLTIWEYPTCNKIADIHAHESRILHSALSPDGELLATSSADENLKFWNVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KQB3</accession>
    <name>A0A167KQB3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_173056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286676.1">
        <property type="nucleotide sequence ID" value="XM_018436932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KQB3"/>
    <dbReference type="GeneID" id="28997838"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_173056"/>
    <dbReference type="InParanoid" id="A0A167KQB3"/>
    <dbReference type="OrthoDB" id="2280705at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="437" mass="49161" checksum="EDD7ACA6FD962851" modified="2016-07-06" version="1">MPNNTSRLLGLDLPAFYQFGISDKSDPPMEREYKVTEASIGGDHFAAIFFGSTIWNNTVGYQSLEDNGIFRSSIKYRVQDRQVVGGFAESIWVVYTVIFFVLAVILLGRIRSSWLLVPFILFAILADTELILKLVQGHPDEDNALDTATRSSTIHRLPILSVLLFDGIIISQLVFINHLAIAFSQRTRWASLRYFEPSEKSLIEPNMSVITKDDLTPSPVRPWVYWLNLVIVFLYVVITVVYLGFEILERTADISYALVVPICITGMAVLAVTNALVVWGSNQFRSARHIRVLRQNHRNLSYLLLSPILFSVTLTTTATLSWVIYFAAFVNVTSDTPALLPITSTVWFILEGLLIYLPLFGILLMCFFVQKLDLLCIYQPKLSPSSSLTARKPVMTTPRKDSIQKDGEDGFVRLSLENNFPLSVPPAAAPHHHGMRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KUF5</accession>
    <name>A0A167KUF5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_149919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286956.1">
        <property type="nucleotide sequence ID" value="XM_018432365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KUF5"/>
    <dbReference type="GeneID" id="28993271"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149919"/>
    <dbReference type="InParanoid" id="A0A167KUF5"/>
    <dbReference type="OrthoDB" id="2262048at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="59" mass="6947" checksum="ABD86B2FBE7C81C3" modified="2016-07-06" version="1">MPSKKESCDSTPLQQCLLANNNDQTKCRKEWDDFQRKCREKQKKESNKPCETCKLPEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KVF3</accession>
    <name>A0A167KVF3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vaculolar membrane protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_13553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287019.1">
        <property type="nucleotide sequence ID" value="XM_018429728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KVF3"/>
    <dbReference type="STRING" id="763407.A0A167KVF3"/>
    <dbReference type="GeneID" id="28990634"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_13553"/>
    <dbReference type="InParanoid" id="A0A167KVF3"/>
    <dbReference type="OrthoDB" id="431202at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022127">
        <property type="entry name" value="STIMATE/YPL162C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735:SF1">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12400">
        <property type="entry name" value="STIMATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22863" checksum="432F76A2702855E7" modified="2016-07-06" version="1" fragment="single">GCKLLDSFAIFIQICLGAVAFSTLIIKRQREQPQRPLLIWGLDISKQLMGGAVVHALNVIASYFTGGNHEGQHSNPCVWYFLNILVDTTIGIGVVWAFIKIVHIIATRYRLSGLQSGVYGGPPFRKQVKRWGKQMVVYVCALLTMKIFVVLLFQLFPSIAVFGKWMLGWTMGNHKLQVVFVMLIFPLTMNTMQFWILDTIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KVH5</accession>
    <name>A0A167KVH5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_172821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287027.1">
        <property type="nucleotide sequence ID" value="XM_018436880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KVH5"/>
    <dbReference type="GeneID" id="28997786"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172821"/>
    <dbReference type="InParanoid" id="A0A167KVH5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="141" mass="17024" checksum="6F8090C7CAA17730" modified="2016-07-06" version="1">MNKERIEYGYAFWCEQHQHERQSAKEKSCKNTTRFDEYNSFGTFYLSFYILTFYFQPLDMFIFFIKPVLVVNNSVYINVMKLDKLECSRLAVGNPCVIFNIDWLSMHFNMHIFEDGWDQLVTVFRMIPDTPQSEHHVDFRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KW21</accession>
    <name>A0A167KW21_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_172854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD69019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287059.1">
        <property type="nucleotide sequence ID" value="XM_018436884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KW21"/>
    <dbReference type="GeneID" id="28997790"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172854"/>
    <dbReference type="InParanoid" id="A0A167KW21"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="119" mass="13670" checksum="87CF2A7471518534" modified="2016-07-06" version="1">MCSGKTKIVKRVSVTHVCHAIYIHKGNEVQTVYFIIDTLETLTRDVIYALGVCMIVYIYPLSISGIYFIMKPNFIGRRWNLLIQSILFASDNHDNDNDNYNYNAKLSKVGYSDILKTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L1V6</accession>
    <name>A0A167L1V6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_156229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287439.1">
        <property type="nucleotide sequence ID" value="XM_018433473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L1V6"/>
    <dbReference type="STRING" id="763407.A0A167L1V6"/>
    <dbReference type="GeneID" id="28994379"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_156229"/>
    <dbReference type="InParanoid" id="A0A167L1V6"/>
    <dbReference type="OrthoDB" id="373498at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18090">
        <property type="entry name" value="Arginine_MT_Sfm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="SFM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517:SF1">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="SFM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="213" mass="24419" checksum="05CAFE97C0D36C65" modified="2016-07-06" version="1">MSKRSFIIEHMEDDVHEWCVLEYKHMLMNIGPDHLYFSGLTQKCLESGMPEELKKANCHQEDVLHLPNVDPSEICLLDPAGTSELAPEDGDKFKYFLFGGILGDDPPKDRTKELRKLGFAGRRLGPVQMTTDTAVNVTKRVVEDRIPLDKIPYIDYPELKFSRHESVTMPFRYIANLKTIVTKDGKEKVIKKPLMPPGMLELIKKDNDESLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L7C6</accession>
    <name>A0A167L7C6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase-like protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_116012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MT-A70-like family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287797.1">
        <property type="nucleotide sequence ID" value="XM_018428491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L7C6"/>
    <dbReference type="FunCoup" id="A0A167L7C6">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167L7C6"/>
    <dbReference type="GeneID" id="28989397"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_116012"/>
    <dbReference type="InParanoid" id="A0A167L7C6"/>
    <dbReference type="OrthoDB" id="61116at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF4">
        <property type="entry name" value="N(6)-ADENINE-SPECIFIC METHYLTRANSFERASE METTL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD69757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="27566" checksum="2A196CA5ACE0E384" modified="2016-07-06" version="1">MDTLTDHGKYKTDRVFFISFIDVQYITAINIEGFDCIVMDPPWPNKSVHRSSHYETQDIYDFFKIPLPSLLSEEHPSLVAVWVTNRPKYRRFVIDKLFKAWGVTWVTDWYWLKLTTKGEPVMPLDSPHRKPYEQLIIGRRIPESTGEIPSNINIPPRILASVPSNRHSRKPPLDSILAPYLPNKPKCLELFARCLTPGWTSWGNECLKFQHQHYFTSTPNHNESSETEPSRLASDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LDK2</accession>
    <name>A0A167LDK2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ER transporter 6TM N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_60115</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288255.1">
        <property type="nucleotide sequence ID" value="XM_018440601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LDK2"/>
    <dbReference type="FunCoup" id="A0A167LDK2">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167LDK2"/>
    <dbReference type="GeneID" id="29001507"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_60115"/>
    <dbReference type="InParanoid" id="A0A167LDK2"/>
    <dbReference type="OrthoDB" id="68611at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023244">
        <property type="entry name" value="Brefeldin_A-sensitivity_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052430">
        <property type="entry name" value="IVT-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804:SF3">
        <property type="entry name" value="PROTEIN BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02047">
        <property type="entry name" value="BREFELDNASP4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="634"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="657"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="683"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="709"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="745"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="8">
        <location>
            <begin position="113"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="9">
        <location>
            <begin position="628"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="7">
        <location>
            <begin position="760"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="506"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD70215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="994" mass="112938" checksum="B4234BCFDB9598A8" modified="2016-07-06" version="1">MSWIKLVQWTKSLFLGKKELWKKIIKCTVAYEIGIILVLIPEVSPHLGAVPYLLPLGTLFFNPSGTTGNQCIEMILNIGMMIIPVIWSAIVAYLCTLYNRALLNGHKGLYSNGAGVIAGIGFGISMMGIAYYRLKYPRLYIPALQGFTIPMFALTKGIYNTSFNIISIVDIFYPIIMGGALALLTNIFLWPATASKSFETSLEDVLCSISQILDFVHTDMLKNDDAGIMAGDLELARKLSTMSAKLQADMTKMNKAWSEAKYEVVVSHFYPRWYKATVHSVEALCQSMLGFSLAIEKEARIMLDIRISRQLEESYRGISNEKVTEHDTLRQRQPGVNNLDVYSTHTVNLISASNPIKYLHIIHLQNLIQPELKQFLRTCRKIMEDIRVKMADRKAIPRKRTQSKNSLSTHTSPEFLQGAESSCSLDKALGDIKATYTLLHHEFKDRSMTPMEEHYLVYTIVFTLIEFGKEMENLEMFVDELLRRREPRSWARLFFPRVPLKKWLSKGGNDNKGEHDPSEQTLFSKEVERVETRPGLRSQASGVSKPRETSSSINRSRSYSSMETDYGNFTDEEYPLQNAPGRHAWNRWLRSVFDFLQSGPTRYAIKFGLVTEILAFMAWLPIPGVNGLYNENHGQWALLSAMVVFNYTVGSTMQQCFYRIVATILGAVCGYIALLAGNRNENPYVVAVLVLVFQIPLWYFLLGSTYPRIGFISLLTMSVIVSTGYSNNTNESLFDPVWKRTATSIVAVLVAMIIDNLFWPVWAREVMRKQLASLLNDTGIQYSKVASLVCQENTSSYRYQSTLADTTIQSKLLWTQLQSAREMLQLSCTEPRISKAPFPIESYQKIIEHEQKILYWISHMIRAQKLIGPEVRKGIMNPMNPHRKILASIVHLYLFTLSGSLGTKSALPASLPSAEEARRKLQQRQAELWKEQYDTLYSMHTPEAHNECDMMVYWHTYAAGSVEVVMEQEAIGSVVAKLMGQHIFRAATKDWIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LJF0</accession>
    <name>A0A167LJF0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_24267</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288634.1">
        <property type="nucleotide sequence ID" value="XM_018439834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LJF0"/>
    <dbReference type="FunCoup" id="A0A167LJF0">
        <property type="interactions" value="789"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167LJF0"/>
    <dbReference type="GeneID" id="29000740"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_24267"/>
    <dbReference type="InParanoid" id="A0A167LJF0"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="7">
        <location>
            <begin position="30"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD70594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="285" mass="31254" checksum="87A359AF4D6B4F9D" modified="2016-07-06" version="1">MFPNGAGKGLGSATGALIVLGALGYGVNASLFNVDGGHRAIKYTRLFGVQNTVYNEGTHFVVPWFETPIIYDVRAKPRNVASLTGTKDLQMVNITCRVLSKPRVDDLATVYRTLGQDYDERILPSIVNEVLKSVVAQFTASQLITQRERVSRLVRENLVRRALRFNIILDDVSITHVGFSPVFESAVEAKQIAQQDAQRAAFIVDKARQEKQSVIVRAQGEAKSAELISDAIKNKPGFLELKRIEAAREIATVISRSGNRVMLDSDTLLLNVNAHSDSNSTASQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LK75</accession>
    <name>A0A167LK75_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_69527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288676.1">
        <property type="nucleotide sequence ID" value="XM_018442108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LK75"/>
    <dbReference type="STRING" id="763407.A0A167LK75"/>
    <dbReference type="GeneID" id="29003014"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_69527"/>
    <dbReference type="InParanoid" id="A0A167LK75"/>
    <dbReference type="OrthoDB" id="10044727at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="643" mass="74683" checksum="9000DD570D63542B" modified="2016-07-06" version="1">MLLMLFRNSLREAAKGSARVDSFFLPIANSSSAETEIGLDEESDSADEVESKEEFKSRVKDAIIDLSKFAVPVISSTSEQQKLGVAEMGKYEGAYHYLYALINTDMKKMAASKFASDIVYKQKSTWYRARKIRQHAKEYLETRRISLGAQGKHAKRVSVLDDEDIKQQILEWFRSQPRAKRSIAGLSVHLKEVILPKAIGSSLLSDELEIEGSAIKPLSTDCLRRKLISWGFHFKHLGKVVYFDGHEREDVLTYRNAWSKCMMEYYQYSEKYDNVTPSLVSYPQLPEGVKQHVFVTHDESTFYANDYQKYAWVEDGESYCLPKSEGRSIMISEFQCPCHGTMRGYVGDQYKTSRVVFYPGAQYEGYWKKYEVIESRLHKNKKYKKYFIGLRGILQQRSMYRNEAERYSLKRSCNNVAAADSRCCTIHIMERQPDFANQKSALEEIVEGSGHKFELYPKYHCECNWIERYWEAAKKEARRECDYSFQSLNRKINSFLDSVCPPEDDVPEKIRRYFHKSFAYINAYSLGHDAEHAFEIVKQFSKLHKSHQFSSIKNLRNSIDFRDLEDFRCFKSYKGYKGYDGYEGVMMGIRVIEALIALRALGALKTSKTSEILNNSMMSETFLLSPYPFYYAYTVYDDNCLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LVT7</accession>
    <name>A0A167LVT7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADPH--hemoprotein reductase</fullName>
            <ecNumber evidence="4">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_92828</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="4"/>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289228.1">
        <property type="nucleotide sequence ID" value="XM_018443803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LVT7"/>
    <dbReference type="STRING" id="763407.A0A167LVT7"/>
    <dbReference type="GeneID" id="29004708"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_92828"/>
    <dbReference type="InParanoid" id="A0A167LVT7"/>
    <dbReference type="OrthoDB" id="2282236at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="78"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD71188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="233" mass="26036" checksum="80CAA420A61E6DAD" modified="2016-07-06" version="1" fragment="single">MQPRRYSIASSPHLFPKEAHLAVGVVDDVVNGKHYPGLASSFLAHQVPGESKAVLRANFKSSKGVFEMPPDAETPIIMISAGTGIAPFRGFLQERAYQHKHASGPVGECLVFFGCRREDQDRIYGDEFDEYVKEGVISGLHVAYSRQIPPSARKYVQHQVLANANEIWRMMVPLDKSKKPAVVYICGSGAMSRDVRTTFRSMAISFGAAKDEEEADKFIQKLIQSRQYNEDVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M2P4</accession>
    <name>A0A167M2P4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_159295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289627.1">
        <property type="nucleotide sequence ID" value="XM_018433962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M2P4"/>
    <dbReference type="GeneID" id="28994868"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159295"/>
    <dbReference type="InParanoid" id="A0A167M2P4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="54" mass="5946" checksum="303895967AFC815E" modified="2016-07-06" version="1">MFGATPSHFYNISQITARNYTKTTSGFCSRRGDLGAALELLTVNVPWGNNDTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M669</accession>
    <name>A0A167M669_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="14">ATP-PFK</shortName>
            <shortName evidence="14">Phosphofructokinase</shortName>
            <ecNumber evidence="14">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHYBLDRAFT_23567</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14 15">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14 15">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="14"/>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD71919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289959.1">
        <property type="nucleotide sequence ID" value="XM_018439810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M669"/>
    <dbReference type="FunCoup" id="A0A167M669">
        <property type="interactions" value="381"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167M669"/>
    <dbReference type="GeneID" id="29000716"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_23567"/>
    <dbReference type="InParanoid" id="A0A167M669"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000007">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000008">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03184">
        <property type="entry name" value="Phosphofructokinase_I_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 14 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="16">
        <location>
            <begin position="18"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="16">
        <location>
            <begin position="407"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal catalytic PFK domain 1" evidence="14">
        <location>
            <begin position="1"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interdomain linker" evidence="14">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal regulatory PFK domain 2" evidence="14">
        <location>
            <begin position="407"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="89"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="119"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="209"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="300"/>
            <end position="303"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="535"/>
            <end position="539"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="573"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="580"/>
            <end position="582"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="640"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="666"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="672"/>
            <end position="675"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="754"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAD71919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="788" mass="85097" checksum="261FCA80B771BF10" modified="2016-07-06" version="1">MPLPNDTPSHKKSTVPRKIGVLTSGGDAAGMNASVRAVVRYGISKGCHVYGVYEGYQGLVDGGDRIRRMDWKSVRGWLSVGGTSIGTARCMPFKTREGRLKAAENLVHNGIDSLIVCGGDGSLTGADVFRSEWSGLLEELRAADRITEEEATTYCHLTIVGLVGSIDNDMAGTDITIGAVTSLHRICESVDSIGTTALSHSRAFVIEVMGRHCGWLALMAGIATGADFVFIPERPPMEDDWESTMCAVAHRHRELGKRKTVIIVAEGAIDKSLKPIRPEYIKDILTDRLGLDTRVTTLGHTQRGGSPAAYDRILATVQGVCAVDAVLRSTPDIPSPLIGMTSNKVTCGPLMKAVELTHEVAKAIGEKNFARAMELRDPQFAEEFNAYTASTIVDDESDLLPPHLRLRIAIVHMGAPAGGMNAATRTAVRYALNRGHTPFAVYNGFPGLVRGSIEELTWIGVDGWTSRGGSELGTNRAVPGEEVDMGMVAYQLQKFNIQAIMIVGGFEAFSALIELDKARAKYPSLCIPIGLIPATVSNNVPGTDFSLGSDTSLNSIIDACDSIIQSARSSRRRVFVVEVQGGKSGYLAVEGGLATGANTVYIPEEGIKLERLQSDVRHLMALYLDDAADKAEGRIILRNEKVSKTYTTDVISSILKDEGRGLFDSRTAVLGHIQQGNTPSPMDRIHATRLAMRCIDFVEQHTHEALEKAHVLGESVPIELTSAPESIAVVGLTGAEVHFPSVRELLPTTDVINRKPVKAWWFEHRGLVDLLSGRGLFTPEAQASLEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167ME52</accession>
    <name>A0A167ME52_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_169714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290626.1">
        <property type="nucleotide sequence ID" value="XM_018436142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167ME52"/>
    <dbReference type="GeneID" id="28997048"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169714"/>
    <dbReference type="InParanoid" id="A0A167ME52"/>
    <dbReference type="OrthoDB" id="6435233at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="122" mass="13504" checksum="2D478A67FCAAC322" modified="2016-07-06" version="1">MTPPTSSITKPKRQELDVFIRGRIIGQWEKDATYGEISKALDILKSTVGNVVKAFRDKGVSKPLTHLGREPKVTKRTQSAMVCSFRSEPFVSIAAQHQRLVDVGISICMTTFLLTQQLASQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MHI7</accession>
    <name>A0A167MHI7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_77996</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0014 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290904.1">
        <property type="nucleotide sequence ID" value="XM_018443322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MHI7"/>
    <dbReference type="GeneID" id="29004227"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_77996"/>
    <dbReference type="InParanoid" id="A0A167MHI7"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005226">
        <property type="entry name" value="UPF0014_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30028:SF0">
        <property type="entry name" value="PROTEIN ALUMINUM SENSITIVE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30028">
        <property type="entry name" value="UPF0014 INNER MEMBRANE PROTEIN YBBM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03649">
        <property type="entry name" value="UPF0014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD72864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="322" mass="35964" checksum="D013105A04DC8F92" modified="2016-07-06" version="1">MVLDNQSQHEQIELGWINVVEASSFVIFAAFISLIMGVKLEVSLIVSGIRCVAQLTMMGYVLDDVFKTDNIYVVLFLSLVLVILGTYELVFNRAKKTFDGLFLVMFFILLSSNCLVAYLGSAFAIQQDPFWKPTVFIPIVGMLLGNSMSSVAMATERCLDQVSVHAPLLETRLAYGASRFEASLPLAVETIRMAMLPTITQLSVMGMINIPGMMTGQIMAGTPMKEAVIYQQCIMFMVAASSTFGVVMAVGACMMILIDKQQALRIDKIIDTSSFIQRIKSSKVTKFRVVRFRTVTLRTCLPAALFNRRRRHEAKYEEVELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MPS9</accession>
    <name>A0A167MPS9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Late embryogenesis abundant protein LEA-2 subgroup domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_145866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291516.1">
        <property type="nucleotide sequence ID" value="XM_018431548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MPS9"/>
    <dbReference type="GeneID" id="28992454"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145866"/>
    <dbReference type="InParanoid" id="A0A167MPS9"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117070">
        <property type="entry name" value="LEA14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30369" checksum="E4185430839FFEA1" modified="2016-07-06" version="1">MNSEHDLLSSTYTYKPSLRPEAADTLPEKQYFDVYSNHSKRWTDYACCICFPCLPLWARSISCFALLLIIGFVITAGALMSTFKIPRIDYNGSTTHPDNLPAFQRNGSSNTFTFNMGLKIGVMNPNVENLALDSVKAVAYYINQPDQTVGGGEMYNLHLKAHSITNVTFPFQVVYDPSKDKDHEMLRDIVDLCISPKQNNSVPTLTFHYDLMPVVKIISLTYQPIYHQVVEVTCPVQGEQLLLLIKDMIVSYLPGVLLKSHLAALLHALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MXG5</accession>
    <name>A0A167MXG5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_144852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292439.1">
        <property type="nucleotide sequence ID" value="XM_018431312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MXG5"/>
    <dbReference type="GeneID" id="28992218"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144852"/>
    <dbReference type="InParanoid" id="A0A167MXG5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="99" mass="10772" checksum="CC47086A4AAAA1F2" modified="2016-07-06" version="1">MPINNASQSTNTNISLSKLPIFPVLSTGSSMSTFSFSISTPLTTIFGQQPIAIKGLPGVHWGATQEVAQVGVFRLQLFHLLPVMDVVVVEVEEVFKRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NB81</accession>
    <name>A0A167NB81_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_166803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293609.1">
        <property type="nucleotide sequence ID" value="XM_018435494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NB81"/>
    <dbReference type="GeneID" id="28996400"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166803"/>
    <dbReference type="InParanoid" id="A0A167NB81"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="148" mass="17160" checksum="E6E37991C1B6C469" modified="2016-07-06" version="1">MEKVMGNRKTGSPAVCDTTKPMEWIHDKDGKQSNGDDDNTDEESAENSHSSNNEEYDSQNDNMSVLCSPPSKSSSSRKRRRVDIKYKELAEELEVLKDDLYIKQERKFIHRKFENMMKAVAELIKVQNWSDEKVQEQTDDVYNKTYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P2B8</accession>
    <name>A0A167P2B8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_40386</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295151.1">
        <property type="nucleotide sequence ID" value="XM_018440141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P2B8"/>
    <dbReference type="FunCoup" id="A0A167P2B8">
        <property type="interactions" value="596"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167P2B8"/>
    <dbReference type="GeneID" id="29001047"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_40386"/>
    <dbReference type="InParanoid" id="A0A167P2B8"/>
    <dbReference type="OrthoDB" id="1727351at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.60.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_eS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018273">
        <property type="entry name" value="Ribosomal_eS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00712">
        <property type="entry name" value="RIBOSOMAL_S17E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD77111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16806" checksum="0E271FB6A5024785" modified="2016-07-06" version="1">MGRVRTKTVKKASRVLIEKYYPRLTLDFQTNKKIADEVAIISSKRLRNKIAGFTTHLMKRISRGPVRGISFKMQEEERERRDQYVPEFSALDTSAIEIDPETQELLKSLNFENLAGVQVTNPIANDFKPRRRGDRAPREKTVEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P5U8</accession>
    <name>A0A167P5U8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_93050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295344.1">
        <property type="nucleotide sequence ID" value="XM_018443814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P5U8"/>
    <dbReference type="STRING" id="763407.A0A167P5U8"/>
    <dbReference type="GeneID" id="29004719"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_93050"/>
    <dbReference type="InParanoid" id="A0A167P5U8"/>
    <dbReference type="OrthoDB" id="20582at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019163">
        <property type="entry name" value="THO_Thoc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375">
        <property type="entry name" value="FMS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375:SF3">
        <property type="entry name" value="THO COMPLEX SUBUNIT 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09766">
        <property type="entry name" value="FmiP_Thoc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD77304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="149" mass="17382" checksum="DF4814B01B6BB7A0" modified="2016-07-06" version="1" fragment="single">GTLPEDVLEGEKGMTLLKTIDKIMDLHALAFGSTRVSKNLTAEAKTAMDARQIGLQNVMYEKRHLLEEIVKCRDFRSVYQDVDLIPLDEFNAVAPPAYRQDNSNQHIEMINRLKFEHEARMRQEKLQVERVKLIKDNRKAQEKLDRFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P6F3</accession>
    <name>A0A167P6F3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_60469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295378.1">
        <property type="nucleotide sequence ID" value="XM_018440647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P6F3"/>
    <dbReference type="GeneID" id="29001553"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_60469"/>
    <dbReference type="InParanoid" id="A0A167P6F3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="205" mass="23636" checksum="B1EA6FE92ACB181F" modified="2016-07-06" version="1">MILLIEQQQQQAFVSIKYTWITSPFFTSTSTSTDTNTNTNTNTDTDTSTSTDTAMVIYHETYILGIRNTLQNHLRMTSAELTRPKLFGKKNREYKCHISGFSLYMYKWSVEVKRKYTHILSKGIHWSLYHPTFIGGGNIATNCSLCKWRVFIPLGIFMQILEGECDIKKKRNICVPERIFLVQARLGTILARENSLALFVGFKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P7F3</accession>
    <name>A0A167P7F3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_60532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295439.1">
        <property type="nucleotide sequence ID" value="XM_018440656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P7F3"/>
    <dbReference type="GeneID" id="29001562"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_60532"/>
    <dbReference type="InParanoid" id="A0A167P7F3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="161" mass="18318" checksum="883750596BBBDBC8" modified="2016-07-06" version="1">MRGRNQFIRSVVEKIFFCFGRVTVKTGFVYSSAWTLLGADQTVLRLLGADQTVLKTIGCGPDGFGDYWKRDRVYLTKVKDTRIRRVWCDKQDISKYMKIRSVLMKMVIYDTTSIKNAISICADFESVVTLGLAQIKKENNIVVATADFESVVMLVLAQVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PA87</accession>
    <name>A0A167PA87_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHYBLDRAFT_179903</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295596.1">
        <property type="nucleotide sequence ID" value="XM_018438229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PA87"/>
    <dbReference type="GeneID" id="28999135"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179903"/>
    <dbReference type="InParanoid" id="A0A167PA87"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF8">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="16">
        <location>
            <begin position="694"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="470"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="906"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="470"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="906"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAD77556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="985" mass="112186" checksum="2F12FE522D928DF1" modified="2016-07-06" version="1">MQNTIDITPLEEEPPTKPTENVYRKRHASLMPSSSPRHSSRHYFQRRLSVPDLHRLKKEWGKYQSSGIEDLELSKLQVDLLNIQSDIPLKRPLIRVKMGSSKYYTMRSRSPTGDWNEGFVFVVTYHTQLFDTIEFDLYDQPRKRWPSNVKHLGKAKLKLSKLAGKDDIFVTFLPVYEYHIRRSLPAEILDTLQESSLRLKKMVDAAVPPAKLIGSLQIRIRYHFQQPSDVPTLAIAPYPELLQQRGCNGANSIVSESDDDQPGYYSDTASINTASPVQKLSIGTNNIINNNNDNDNDNQPRLSAVDGCIDETGVWPITTFPTGNTLSPPDNTPRNNSTSSQHNRGELAQDEHVVNSLFMNRLSTIMTSQVPCSKQNTINTFQRPNISATSSREGLNSDIDWRQNESRLELHPNSLRSSTTKTRDCQWLRAILWPVNRSKLASNRGRRYGFSQNDADETQSTLPTIRIQDANNNDNANANDNANVDNDRHKGKEKVKEKVKEQKGRIKKGAEKARYIIHSVNFGDKNFGFQWMQDSFEDVAISHPLIDSLVGLVVSGQTRAMVRALIKLANAFGQGFKVTGFQLLKAMLVLQKYYQSLPEPPPEPLIYDRTLVNDSRHYFDYALIAYGWRGLVYLGAYGQYIRGARHRRSNRMAILRYLQIPPEDLLGYEYGLRKGAAFQPSYFLAIDRSRKAIVLSIRGTWSLYDAITDLVCLYKPWKGGLVHSGMLASAQWFYTEIVPQIFRYIHHHRNELSSFIITGHSLGGGAASLLTMMVVDHLEELRDISRNPTFTLRCYSYAPVALSSQQLGSQYDRFIYSFICQDDIVGRLSYGTAMELKELVMDTIGAYETLGGWRKVMYDSETREVCFEIISKRRKQIYNNAEELYPLLYIPGKIIHIVRKREMRFGGNERHKKDGPEAGENRRGKESKRESVSKHIPGASRHTYTMHVGNRAISNEMLVTTKSVEDHMISSYRNAFSQLGASSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PC30</accession>
    <name>A0A167PC30_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_185581</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295678.1">
        <property type="nucleotide sequence ID" value="XM_018439097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PC30"/>
    <dbReference type="STRING" id="763407.A0A167PC30"/>
    <dbReference type="GeneID" id="29000003"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_185581"/>
    <dbReference type="InParanoid" id="A0A167PC30"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12400">
        <property type="entry name" value="RRM_Nop6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000376">
        <property type="entry name" value="Putative RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034228">
        <property type="entry name" value="Nop6_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF51">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="129"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="203"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD77638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="254" mass="28251" checksum="980D44F77BC62E8A" modified="2016-07-06" version="1">MAQEKKLTKREQKAAAFKQKSKKKQCFTEETAVPEADDPTHIEPSSGAIPKKEDQKTSKTIADQKPKPTENKKKATKIVVGENDEKDESEKSGSVGAGTKRKQTETTGATNKANKRQQKDENQEKGARFIVFVGNLPYNTTKEELEKHFESVGGVTSVRLLTDKQTGKPKGFAFMEFESSKHLSKALAFHHTLFKKRQMNVELTAGGGGNKSTARKDKLKVKNERLQEERQKKHETIKGTDAPGSSYGNKETEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PC68</accession>
    <name>A0A167PC68_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_164544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295687.1">
        <property type="nucleotide sequence ID" value="XM_018435030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PC68"/>
    <dbReference type="GeneID" id="28995936"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164544"/>
    <dbReference type="InParanoid" id="A0A167PC68"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="167" mass="19159" checksum="37FF20AADC17F7BF" modified="2016-07-06" version="1">MQDVNSSENTHGSYEKANPYKYGCIMYMHLANYGATQISLVVGMSLSTVKYIIKRVDETGSPEPRKGSGRPRKIDERTERHLVQIVLFIDGDFIKVKYFNSDSKVFSCLEIYKHEGMISSCIEMIVLNTVLFLYKLVEIFQDEDVLINTQINDCQDSSCTNFRSKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QBA3</accession>
    <name>A0A167QBA3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_139438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297449.1">
        <property type="nucleotide sequence ID" value="XM_018430225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QBA3"/>
    <dbReference type="FunCoup" id="A0A167QBA3">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QBA3"/>
    <dbReference type="GeneID" id="28991131"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139438"/>
    <dbReference type="InParanoid" id="A0A167QBA3"/>
    <dbReference type="OrthoDB" id="368909at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06168">
        <property type="entry name" value="LSMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034110">
        <property type="entry name" value="LSMD1_Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF5">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 38, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="9"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="83" mass="9543" checksum="5D15BE854702C25B" modified="2016-07-06" version="1">MVADTENIQRLRTYLNFKTRIQISDGRTFIGVFMCVDKDKNIILAHAEEFRGDEKRLVGLVMIPGKHLVKVEAENMNADDLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QRY9</accession>
    <name>A0A167QRY9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase class V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_130479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298207.1">
        <property type="nucleotide sequence ID" value="XM_018429366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QRY9"/>
    <dbReference type="FunCoup" id="A0A167QRY9">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QRY9"/>
    <dbReference type="GeneID" id="28990272"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_130479"/>
    <dbReference type="InParanoid" id="A0A167QRY9"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092:SF2">
        <property type="entry name" value="HERCYNYLCYSTEINE SULFOXIDE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092">
        <property type="entry name" value="L-CYSTEINE DESULFHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="63"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD80167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="411" mass="46719" checksum="B9D5B1B8D370CB77" modified="2016-07-06" version="1">MAKTTSFGKHLRSDFFFEEDYTPLNHGSFGCYPRSLLPVLHEYQMKAEQHPDRWLRRDMFPVLDKNREILAKLINCDAKDIVFVTNASNAVNSILRSLPFEEGDKILCFNTAYNAVAKTTDYIKDSRKVELVKVELNYPLSDSQVVQVIKETITKQANPERFRLCVMDGISSVPGVVFPFEKVVKLLKEYKILSLVDGAHCIGQIPLNIRHADPDFFLSNCHKWLFAPRGCAVLYVAERLQRIIHPVIINADYQDHSDPADTTSTFQREFGWPGTCDFSPYMCIEKALEYRASIGGEEAIMSYCNNLANRGGELVAKILGTSVMENSEGSLTAAMVNVKLPLYNPRLEAKDIPDYFINTLIYEYKCMAAAYFHNGSWWIRLSAQVYNDLDDFEVVGKALLKVCTSLEKNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QZF4</accession>
    <name>A0A167QZF4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Non-structural maintenance of chromosomes element 1 homolog</fullName>
            <ecNumber evidence="4 16">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHYBLDRAFT_138069</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the Smc5-Smc6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the NSE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4 16"/>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298550.1">
        <property type="nucleotide sequence ID" value="XM_018429927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QZF4"/>
    <dbReference type="FunCoup" id="A0A167QZF4">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QZF4"/>
    <dbReference type="GeneID" id="28990833"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138069"/>
    <dbReference type="InParanoid" id="A0A167QZF4"/>
    <dbReference type="OrthoDB" id="185455at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16493">
        <property type="entry name" value="RING-CH-C4HC3_NSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000270">
        <property type="entry name" value="Non-structural maintenance of chromosomes element 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014857">
        <property type="entry name" value="Nse1_RING_C4HC3-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973">
        <property type="entry name" value="NON-SMC ELEMENT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07574">
        <property type="entry name" value="SMC_Nse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08746">
        <property type="entry name" value="zf-RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="202"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAD80510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="259" mass="29597" checksum="9F1CD8D2994E7B66" modified="2016-07-06" version="1">MNVNCPRPLTMNANQPVDPSSYNDCHRLFLQSMLTQKIVREDQALNLYDEASKLTGVPRTDFSDFVACINQGINEIDLALKRSHNERNGVPVIALVNTLDDEISQMATEYSPSTIMYFRQLAENIITAEDEDYAISSMEAIRLGQKMTPALTQKETQDLLDRLVADGWLFCTRQGAYVMETRTVLELNVYFKEQYGEYMKECQFCLDVVTMGERCESVDCPVRIHRHCAERYFREQPNSTCPLCGTMWSHLNTFGLGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R3P4</accession>
    <name>A0A167R3P4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSm2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_153957</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298814.1">
        <property type="nucleotide sequence ID" value="XM_018433288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R3P4"/>
    <dbReference type="FunCoup" id="A0A167R3P4">
        <property type="interactions" value="876"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167R3P4"/>
    <dbReference type="GeneID" id="28994194"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153957"/>
    <dbReference type="InParanoid" id="A0A167R3P4"/>
    <dbReference type="OrthoDB" id="10256176at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01725">
        <property type="entry name" value="LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000009">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016394">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD80774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="104" mass="11843" checksum="CC45B8FEFBF373BC" modified="2016-07-06" version="1">MLFYSFFKTLVNEQVTVELKNDLVITGTLKSVDQFLNIKLDDIQVIDEDRYPHMISVKNCFIRGSVVRYVQLPQQAVDTALLQDAARREAAQPSSAQQANVRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167RAE5</accession>
    <name>A0A167RAE5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_138768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299259.1">
        <property type="nucleotide sequence ID" value="XM_018430072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167RAE5"/>
    <dbReference type="STRING" id="763407.A0A167RAE5"/>
    <dbReference type="GeneID" id="28990978"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138768"/>
    <dbReference type="InParanoid" id="A0A167RAE5"/>
    <dbReference type="OrthoDB" id="2506357at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="148" mass="17117" checksum="238773E3830E4205" modified="2016-07-06" version="1">MDWKTIKTLLHVDPWRLEEALEAGLVISSFPMSLCINYNDMQNVINDQLNELSRQNAVDRTSFHKGNDLSLLSWISPWQKKQIIEAADEWCIDSTHKTCKSLVGSGKHSYLYTIIIRSNIMNKSVPVCFFITNAELTSTLRQWLTLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NAP5</accession>
    <name>A0A162NAP5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_168918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290688.1">
        <property type="nucleotide sequence ID" value="XM_018435969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NAP5"/>
    <dbReference type="STRING" id="763407.A0A162NAP5"/>
    <dbReference type="GeneID" id="28996875"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168918"/>
    <dbReference type="InParanoid" id="A0A162NAP5"/>
    <dbReference type="OrthoDB" id="2278933at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="22793" checksum="A035E5CD6C2C048C" modified="2016-07-06" version="1">MSFTSLGAKIDTSVGNNINGAYNFWIHGTICHRIGSILPVTESDIAHPKFAQIYIYDSAAQIDQRQYHSPQLERSVLEKIQFILMETNPFVHLFRTMDQISQEKRQSIDLTLRLVAEGPWDQRRYNAPTASEIAVLIMNNEEGTSRDIVLHTRANFQQNINEYHQSYDALHYVLLFPHSEDGWTIDASSLSGEHVTIMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NBX5</accession>
    <name>A0A162NBX5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CCCH-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_150910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285864.1">
        <property type="nucleotide sequence ID" value="XM_018432572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NBX5"/>
    <dbReference type="STRING" id="763407.A0A162NBX5"/>
    <dbReference type="GeneID" id="28993478"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150910"/>
    <dbReference type="InParanoid" id="A0A162NBX5"/>
    <dbReference type="OrthoDB" id="2417221at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16465">
        <property type="entry name" value="NUCLEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16465:SF0">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="98"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD67824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="156" mass="18478" checksum="DAAE7DBC324F9858" modified="2016-07-06" version="1">MPRKYECDFCQCSFPDNSTNRKKHLQGAVHQANRKRHYDWFKDPNEFVAEQMNKPPCRHFFTHGQCEFGLSCKFSHIAYATSGEPILSPELIQWLQSRNQEQNQQSIAHQKKTEQQSARKRSRYRLPTGWKVRSLPPSLCPPKKQEYDWTDTGYWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NC03</accession>
    <name>A0A162NC03_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_146272</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290998.1">
        <property type="nucleotide sequence ID" value="XM_018431614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NC03"/>
    <dbReference type="STRING" id="763407.A0A162NC03"/>
    <dbReference type="GeneID" id="28992520"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146272"/>
    <dbReference type="InParanoid" id="A0A162NC03"/>
    <dbReference type="OrthoDB" id="289247at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052110">
        <property type="entry name" value="MCFD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23104:SF1">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23104">
        <property type="entry name" value="MULTIPLE COAGULATION FACTOR DEFICIENCY PROTEIN 2 NEURAL STEM CELL DERIVED NEURONAL SURVIVAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007837699" description="EF-hand domain-containing protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="63"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="110"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD72958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="145" mass="16376" checksum="3A1579140ACB0AF4" modified="2016-07-06" version="1">MRTSSPVLCFLISCLLLPLAFAGPGTHRFEAGHSNYGEDLKNKQHIQEHINALAKDGQAPKVEDKDMVYYLFVVHDKNADGHLDGHELRAAFTDFEEGDEDPTKFISLEEVTEMVDHVLEEDDIDGDGLISWDEYLQSQLYHGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NF78</accession>
    <name>A0A162NF78_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_158785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291798.1">
        <property type="nucleotide sequence ID" value="XM_018433856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NF78"/>
    <dbReference type="STRING" id="763407.A0A162NF78"/>
    <dbReference type="GeneID" id="28994762"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_158785"/>
    <dbReference type="InParanoid" id="A0A162NF78"/>
    <dbReference type="OrthoDB" id="161570at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="228" mass="26524" checksum="3451E611CA3E2B18" modified="2016-07-06" version="1" fragment="single">MMIQNNVQQQYQSSTSSQNVHKDKPEEQEHDRDLDLDQDQEQENNKEDSQNQLSDYEKLRLKRIEENNQTLLKLGLISEMSEDSDDVIHYESMMSKKPLENAPLVLVMVGHQPIEPRQIGLYRETIVQIALEAVKKLAPLGMLIIGTKDIRQKDNGKLWPMSMLVLEDIERAIDRSVLKLKEMVVTVPEGHSKDRQQKNLNTEVEEELEIVDEHLTIVHAIYLVFQRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NH46</accession>
    <name>A0A162NH46_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_149357</name>
        <name evidence="3" type="ORF">PHYBLDRAFT_149363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287609.1">
        <property type="nucleotide sequence ID" value="XM_018432258.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287614.1">
        <property type="nucleotide sequence ID" value="XM_018432262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NH46"/>
    <dbReference type="GeneID" id="28993164"/>
    <dbReference type="GeneID" id="28993168"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149357"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149363"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD69574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="349" mass="39407" checksum="56D7473EDCB34A73" modified="2016-07-06" version="1">MNLSNSGRDKCLQAVFMETRREFSPVSKQNSRNKIRKAKLNMEIKTNSTKQHGKNGIKPSISPSRWVGPKAHEESRLGYGYNKNKFLVIIQDYWLRTAKRAQGRNNVNHKASDKAIFQGFFLSLDFFVRDNTNHWSVYPEDKGYQREFVSGSWCGKPRSGSSSAIWWSNPFVVDPIAASWHIVSAGSLVVYCWWSRIPPAGGQGPIRPVIEEHFAVPSLNPTSRIPEMVKPRFAFMSKSNSKFCPSQSQSPNVQTLSKYCRGAFIYKSKVWVVPPSLKAKSISKKGSNAKFQKQVPKEKPKTKSEAYTKSCKKNGHILSPPLQKDQKKSELEAYTKSSNPKGSNPKTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PMR6</accession>
    <name>A0A162PMR6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_167751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292377.1">
        <property type="nucleotide sequence ID" value="XM_018435712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PMR6"/>
    <dbReference type="GeneID" id="28996618"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167751"/>
    <dbReference type="InParanoid" id="A0A162PMR6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="209" mass="23989" checksum="59DC28A9917DDD20" modified="2016-07-06" version="1">MFSIANPDEVHCKCTRCNCNPLGYTITDKRTAKRHAQNDNDRNIDKTINEQIVLTAEVNTGEADMDVDQIEEHIEYDNYSDGAPSPEQYVNTHLPLLVEESLFETEEYTSEYESEYESSDEFEQEEQNREQEQESTENLPENIWHQVIAVFTVIFISSFIVDEGAVILITFINTILGHYGEDFRLPTSIPGLRKMTGTGKIRTINILSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PQB7</accession>
    <name>A0A162PQB7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AWS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_102930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293047.1">
        <property type="nucleotide sequence ID" value="XM_018427746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PQB7"/>
    <dbReference type="STRING" id="763407.A0A162PQB7"/>
    <dbReference type="GeneID" id="28988652"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_102930"/>
    <dbReference type="InParanoid" id="A0A162PQB7"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046975">
        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042294">
        <property type="entry name" value="SETD2_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46711">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46711:SF1">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00570">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="AWS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD75007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="101" mass="11953" checksum="CFF40D44EA9816E5" modified="2016-07-06" version="1" fragment="single">DIDDPSEACGDDHTCINRLMFMECMVDDCPCGRFCRNRRFQLRQYARVDVIQTEKKGFGLRALTDLPTNAFIMEYIGEVIPNIEFIRRTKDYEEEGLEHYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PQX1</accession>
    <name>A0A162PQX1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial group I intron splicing factor CCM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_78964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293207.1">
        <property type="nucleotide sequence ID" value="XM_018443404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PQX1"/>
    <dbReference type="STRING" id="763407.A0A162PQX1"/>
    <dbReference type="GeneID" id="29004309"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_78964"/>
    <dbReference type="InParanoid" id="A0A162PQX1"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140053">
        <property type="term" value="P:mitochondrial gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040152">
        <property type="entry name" value="Atp25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28087">
        <property type="entry name" value="ATPASE SYNTHESIS PROTEIN 25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28087:SF1">
        <property type="entry name" value="ATPASE SYNTHESIS PROTEIN 25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="790" mass="90725" checksum="E3436EED14E4485C" modified="2016-07-06" version="1">MLQSLYAGNNLLKTRGIQLKSNIHRLASRSAPIISRNLPVTFYPTRQFSSTLSPNNQTNEPVAVTRNTVGTIKKNKPLFSVHDDIPQKLASYEALGDVEGAFNYVKELHAKNLATKEIYERLVTLLSENPTEIAKINYVLNWFTQSSRSKNKKILEDIDLWCKVMGLGFKLKGTSREQALRMYLQAFEATFPYSKLTTQTAWVTKIRAHGILCQPLKVTECLKEIKDSPKALEAVDEKQIFEYAILAYANCQMTELVDKHMQLFKDTPPSKDMLKSLTLTNAFRGNIEATKKYSDLTERIYPSVDLTSVRLLSYQRDLVAQYKNEARIRGTHNAPLNLDQDKAAAWNELAESLMNDDKRPLNINECNNIVGYLATANSLDNKQFPMERAQGFVDNYMTKHSIQPNETTYSYLLTGYARTHEYNDGAKNSRLDKALETLHLMLSKNLSVVNHRNFSALLKACIPHKNENYIFDYFRYNSAVKTSFQNQKLKKIFLDKRFFEIEKLMLEYDVNYDRYTFMNMMTCLGGSGLYIALWNRWGLTKKYGIKRDAALYQHMLALAARDSEQARFALATVKSELARDIGQDKMTKPLYFSLLECSVSAQNTTMTGQIIETLRKDFELTTEDYNTLIRSSAFLGDASSKVDDILEEMKKKNIQNNTRTWLNLLSNQILAKAEHNQIQKTFNDYSMYRFEEYGKVPIPIRKQAKTVPFPTGPYTGVDQQIINVYLASLVDHQDLSLLFGILRTSEEQELPIRLTVNTINWIKNLAQKEKSKDDLAWFINESKLGKIIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PR35</accession>
    <name>A0A162PR35_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_166484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293257.1">
        <property type="nucleotide sequence ID" value="XM_018435426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PR35"/>
    <dbReference type="GeneID" id="28996332"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166484"/>
    <dbReference type="InParanoid" id="A0A162PR35"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="113" mass="12263" checksum="F9043C6F6AD4B608" modified="2016-07-06" version="1">MTPSSLSPHYAAQSPSGRKPDLVAKEVLEWWQTNGKHPFIQPHISSPSNVGANSPENLPLGDKVQLIRLPVASPSAVKEFSQVSSEEPAHLTTGLCNCSTAKLTANIFYSKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PYH2</accession>
    <name>A0A162PYH2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_123890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293466.1">
        <property type="nucleotide sequence ID" value="XM_018428961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PYH2"/>
    <dbReference type="FunCoup" id="A0A162PYH2">
        <property type="interactions" value="510"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162PYH2"/>
    <dbReference type="GeneID" id="28989867"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_123890"/>
    <dbReference type="InParanoid" id="A0A162PYH2"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14019">
        <property type="entry name" value="STKc_Cdc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF23">
        <property type="entry name" value="CDC7 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="11"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD75426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="380" mass="43269" checksum="6F7FAAF4FFC5EFBD" modified="2016-07-06" version="1">MASVRSLSFYYKLVDKIGEGTFSTVYKAIDIRHERYKNEDWEAQLISGASVGRKIRGREGATDAQIKNRSKFVALKRVYATSSPKRIASEIEVLQQLRGCPCITPLITAFRQQEEVFVVLPYIQHDEFKKIFLQMPMEDIKCYMRCMFTALKSLHKLKILHRDIKPNNFLYSSRDKMGILIDFGLAQVSIIFSIYFFLATTPSGPSKLPIRRIPSSIDQTDNPKVRGYMINDQRRAIRANRAGTKGFRAPEVLMRVVNQTTAIDIWSVGVIFLSILSGSYPFFLANDEADSLIELACLFGSNAMKECARFHNRTFETNIPSINQGPYNLGSICKTLNSRMFEAWNQTDLKNAIDLMTKCLALKSDERITAAEALEHPFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PZK1</accession>
    <name>A0A162PZK1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_96349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295507.1">
        <property type="nucleotide sequence ID" value="XM_018443964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PZK1"/>
    <dbReference type="FunCoup" id="A0A162PZK1">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162PZK1"/>
    <dbReference type="GeneID" id="29004869"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_96349"/>
    <dbReference type="InParanoid" id="A0A162PZK1"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000002">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041093">
        <property type="entry name" value="Dis3l2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17877">
        <property type="entry name" value="Dis3l2_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="2">
        <location>
            <begin position="288"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD77467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="858" mass="96966" checksum="A5A5586E7E69A142" modified="2016-07-06" version="1" fragment="single">RDDANPHQRRPLFIAHLPFSALTPLFRSRNLVRGLLRVNKRNRSDAYVACEDLDADIYVCGSRDRNRALEGDVVAIRLVDVEKILREKREKEEAKLTRNGGHIRVRQPDEEDENEIIFGGDEDVDTVKPKYCGVVVAILERAQNQVFSGTLTLMRPNNKRAQEEKAAEEAGQDTGRRETPRIVWFKATDKRVPLIAIPIEQAPVNFVENNEAYADRLFVGSIKRWPITSLHPFGTLERELGHITDLPVQTMAILADNNVTDLPFAEQVMLCLPPMPYSFPTDLPDHQRRDLRDTRTFTLDPENSLVLDDAFSIEKLGDGLYEVGVHISDVAYFIKPHSPLDKEARARAVRVELMHKNVPMLPTELTEQVTNLVPNESRYAFSVIWKITSRGVICDTWFGKTIVRSNAQLSYKQGQEAIEGFPISGLEDIAVEQDIRTLYDIATNLRETRFSDGALSQKADELEFEIGPDSSVPISISTKSEFPVSRIIKEFHLLANYYVSQRITSCMPEQALLRRHAPPLDRKIRELQAYAESFLGVSLDITDAHTIENSIESIQDSTLRKLMSVLVLKTLSPPKYFCTGTLDITKFAHYASNVPLFSHFTSPSTRFVDIIVHRQLEAALTDARFYLDRDNVQKLAQHSNVKREAALYARAQSNLLFLALHLNSLAQQNADHVVYRQGVVVAVFENSFDVMVPELNMEKRIHIVSLPMRQRPVYDPVNQSLTMYWKKGLDDEALLAEMAEEEEAELVGMRTERSFKALSIHDNGSLQYRNNISSSSIINNNNNLNNSNSVSSLNTINSTGNGSVNKRMSISRARISDGSNYGPDQGIQTIKALDKIHVMLTIEMVRTPPLIRILAANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q3J3</accession>
    <name>A0A162Q3J3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Adenylyl cyclase-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_157303</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297736.1">
        <property type="nucleotide sequence ID" value="XM_018433595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q3J3"/>
    <dbReference type="FunCoup" id="A0A162Q3J3">
        <property type="interactions" value="367"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162Q3J3"/>
    <dbReference type="GeneID" id="28994501"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157303"/>
    <dbReference type="InParanoid" id="A0A162Q3J3"/>
    <dbReference type="OrthoDB" id="77251at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.330:FF:000001">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.330">
        <property type="entry name" value="Adenylate cyclase-associated CAP, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013992">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018106">
        <property type="entry name" value="CAP_CS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053950">
        <property type="entry name" value="CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036222">
        <property type="entry name" value="CAP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF0">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21938">
        <property type="entry name" value="CAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01213">
        <property type="entry name" value="CAP_N-CM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101278">
        <property type="entry name" value="N-terminal domain of adenylylcyclase associated protein, CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01088">
        <property type="entry name" value="CAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="6">
        <location>
            <begin position="322"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="282"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD79696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="482" mass="52246" checksum="282F659A150838FA" modified="2016-07-06" version="1">MSEFHSLAHLIKRLEVATTRLEDLALSASSASAVSSTSPTNTPPPPSAPAVVQPTGVSEVPVVIEKQDEAINAALQKYLALSAEIGEPISKQATLVASAIQAERDILRISTLAQKPVMSTTIFGKLIDPLQTLLTEVVNIKEKNRGSAMFNHLSTVAEGIPALGWFTCEPAPSPFIRDMKDAAQFYANRVAKEWKEKDPKHVEWSQAFLTVLDNLGRFVKENYPTGLPWNPKGENLETYMSQNNTSTAVLEEYEAGKPTGAAAVFAEINKGTSVTAGLRKVDKSQMTHKNPSLRAGSSIDAGSNKKQAPPTPSKPNKYILKKPARTTLEANKWVVENHENNNTIVIEDTAINQAVYIFGCKNSTIRIKGKVNAVTMDSCVKCGIAIDSTVSTVDLVNCKSFALQVFHVTPTIAVDKCDSGEIYLSKECLGVEILSAKSSSLNVLVPEDIEAEDSEMKELFVPEQLKTTIVDGKLVTTLIEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q576</accession>
    <name>A0A162Q576_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_59230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298236.1">
        <property type="nucleotide sequence ID" value="XM_018440455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q576"/>
    <dbReference type="GeneID" id="29001361"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_59230"/>
    <dbReference type="InParanoid" id="A0A162Q576"/>
    <dbReference type="OrthoDB" id="2290018at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007838999" description="MULE transposase domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13695" checksum="2CC0303D354AD430" modified="2016-07-06" version="1">MSKMVLIFVFLELIQTLAFENKQFITLFVTYKCSALMNALDTIFSENKKLLCYSHMLNSVKKAFSEKTNFIAKKKELMNYVSRTIHSRTKMKFNLALLKINNACTRLEIDDNKARALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q6Y0</accession>
    <name>A0A162Q6Y0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_161274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298676.1">
        <property type="nucleotide sequence ID" value="XM_018434369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q6Y0"/>
    <dbReference type="GeneID" id="28995275"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161274"/>
    <dbReference type="InParanoid" id="A0A162Q6Y0"/>
    <dbReference type="OrthoDB" id="2282487at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="218" mass="25657" checksum="356F523F869877C3" modified="2016-07-06" version="1">MELLQMPLQSYRDYCRGKQLDESRYQNFDMVDENEILLDIVTDRNQSMDLQLHQQASNVQKRKEKSPLKTGTSERKRSARKPYKKFNDEEKDHFFFLVNKKIMTAGKAARRMGIPRRTAYSWLKKRQEKPCDEIQPSKKTAGRPPIFNEIHKDYLLKFINNNPLAVLKQIEESVANEFSDITVCKSTLYDFMTKKCGLTLERAHLNSKKQSKKCRSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T103</accession>
    <name>A0A162T103_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_153458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441028">
        <property type="protein sequence ID" value="OAD65372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283412.1">
        <property type="nucleotide sequence ID" value="XM_018433156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T103"/>
    <dbReference type="GeneID" id="28994062"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153458"/>
    <dbReference type="InParanoid" id="A0A162T103"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="63" mass="7042" checksum="0F0120621EAA7260" modified="2016-07-06" version="1">MYKGAFRAMSPLTKVVWRKITSAQAALHVSLHLYNQLAFSRVSADTATASRTQEPTRLDTYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T8P2</accession>
    <name>A0A162T8P2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_176461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441042">
        <property type="protein sequence ID" value="OAD65053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283093.1">
        <property type="nucleotide sequence ID" value="XM_018437783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T8P2"/>
    <dbReference type="STRING" id="763407.A0A162T8P2"/>
    <dbReference type="GeneID" id="28998689"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176461"/>
    <dbReference type="InParanoid" id="A0A162T8P2"/>
    <dbReference type="OrthoDB" id="2289232at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="19602" checksum="18B2D8C4CF51FE07" modified="2016-07-06" version="1">MKVSNFHKNGAFLVLWVSEWQKEFLENSEEWCIDSTHKTSKSFNTVAGKKPEDCFLFTIGVRNAITNKGLPAKRIMIDCRPIEIGAMEEVFGNSINILSCYWHINRAWEVNVKKHIKVQNSTHASNIACNIIHAVLSNMIHATTSVAYDTLYNKFLMKFGEYEDFILYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TGR1</accession>
    <name>A0A162TGR1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_70372</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD67013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285053.1">
        <property type="nucleotide sequence ID" value="XM_018442267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TGR1"/>
    <dbReference type="STRING" id="763407.A0A162TGR1"/>
    <dbReference type="GeneID" id="29003173"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70372"/>
    <dbReference type="InParanoid" id="A0A162TGR1"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007840018" description="chitinase" evidence="10">
        <location>
            <begin position="28"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="11">
        <location>
            <begin position="68"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD67013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="490" mass="54708" checksum="850130B95E8F6B2C" modified="2016-07-06" version="1">MLITQAIYWFIAIQCTLLVTISSIADAQQIGSTTKATARVLINEPQSALEHNAEENPNYGKLDTLRNINRAIDFHASSFDANTSKNQPGVSAVVMGFIADYTGGKRSSPILNLSSNCNNVENCEQVAHDIKSCQRKGIKVFLSMGGSAGPYHKQKWDPEVLAWWIWNKFLGGDDRTLKRPFGDVLLDGIDFDPEGTNGEGYDKLVDTLRKLFKTAYPPRNYLITAAPQCPDLDMYSMNAMYPLLHPDPKYNAYPDLVFVQFYNNYCSANTFDTKGPAKFNFDEWENWSLKNTNGRTKIYLGLMGKENHMDTGYVNYEKLTEILDTIEPKETFGGVMMWDARYAFSNPVSYLNGIHYGQAVAEYLQFLSRTDDIWMPLLALDTASIYKDTMMPLMVPISHKIASLHEPLECRGQTFLLLRTVTSRILAESFGLSGGDIDDHLLSLGIEPTAPIVPGSRICLGVGIKADTLAVTYVYNATISSIKSRPPLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TJ02</accession>
    <name>A0A162TJ02_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_149970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287012.1">
        <property type="nucleotide sequence ID" value="XM_018432374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TJ02"/>
    <dbReference type="GeneID" id="28993280"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149970"/>
    <dbReference type="InParanoid" id="A0A162TJ02"/>
    <dbReference type="OrthoDB" id="2279623at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="88" mass="10084" checksum="36AD72A38B34CFB7" modified="2016-07-06" version="1">MTTPYYGTKNPNESVKETEEIIFRVVDDLQIPSDDIEKSLEKDTVVNVPRLQESRIQWKIRTGITIFLILTLVIGAIIVSELIHTNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TRP7</accession>
    <name>A0A162TRP7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_172486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287273.1">
        <property type="nucleotide sequence ID" value="XM_018436812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TRP7"/>
    <dbReference type="GeneID" id="28997718"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172486"/>
    <dbReference type="InParanoid" id="A0A162TRP7"/>
    <dbReference type="OrthoDB" id="5596236at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="131" mass="15506" checksum="F15518F4C21F50DB" modified="2016-07-06" version="1">MSVYLRLRLKDKCSTSIDCLSLSRLSFGKFKQVLNPRPYRRTRISTVTYHGLLRCNNLNCLENTDQSEGMHRSWNRDLASFLSFQHILNDPRYNGTIPERLTRVIQIGRIRRQAEGDLQEGRRLRQRLTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TSG7</accession>
    <name>A0A162TSG7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_115349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288712.1">
        <property type="nucleotide sequence ID" value="XM_018428454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TSG7"/>
    <dbReference type="GeneID" id="28989360"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_115349"/>
    <dbReference type="InParanoid" id="A0A162TSG7"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908:SF5">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908">
        <property type="entry name" value="PROTEIN CBG11750-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="1">
        <location>
            <begin position="151"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="344" mass="37661" checksum="F5A3E99013A0479F" modified="2016-07-06" version="1">MAAPVNEGRAALVSRDYSLPPIIKSRANILGKFPKVDLTAEATAKANNGPLPENVQTTDGIAVNATSGPSQAQTLAAIGNSVSIATEVQVQDLKVFTQLSANVYCRVVVPLNQWACAHCSKDETLVSTFFTVLIDTNGFITRNDKSKTISLVFRGTYIYANLYIIGTNDFDFITVDYSPVKNAKIHGGFYKAYLDVQEPVISKMIEQITEYPNYKVAVSGHSLGGSLAEIAAMDLYQRDTRFNSTNIVLHTYGQPRTGNSILGSYFTGTGIEYKRTVHDHNMIPHLPPLSVDYMHVGTEYWETETGPVKICTDFESIKCSNSIVPFTSATDHLSYFGINTGLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TSZ5</accession>
    <name>A0A162TSZ5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_66222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287593.1">
        <property type="nucleotide sequence ID" value="XM_018441607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TSZ5"/>
    <dbReference type="GeneID" id="29002513"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_66222"/>
    <dbReference type="InParanoid" id="A0A162TSZ5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="100" mass="11447" checksum="86A1E0EF2506EA6D" modified="2016-07-06" version="1">MLVDRKRASIHNLGNLKLALRQERKRLGTKYAGHLVRSVSRRSRITIDSKGDPTQNGKSAMLILRDVPFDLIEGQAHKAWPTEIELLLWEVPTYLDLMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U0J9</accession>
    <name>A0A162U0J9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_170717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289393.1">
        <property type="nucleotide sequence ID" value="XM_018436417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U0J9"/>
    <dbReference type="GeneID" id="28997323"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170717"/>
    <dbReference type="InParanoid" id="A0A162U0J9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="144" mass="17164" checksum="FC6522E984A35F04" modified="2016-07-06" version="1">MAYIHYKPYKEFLLMQNASSYKTLIPVFKSTLTQISNIHGPDFIKPIIYSRMFFSFRVCLKYAPIVYFEIQKQNIIIWFGLFVLAVENKEILNNEFQKKKLIMGFITRSGLINEKHCYLKKLESNFAQIWAVRIMQDDICMVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U128</accession>
    <name>A0A162U128_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_69950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290652.1">
        <property type="nucleotide sequence ID" value="XM_018442185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U128"/>
    <dbReference type="GeneID" id="29003091"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_69950"/>
    <dbReference type="InParanoid" id="A0A162U128"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="313" mass="32490" checksum="F73DC7682C1E2ACF" modified="2016-07-06" version="1" fragment="single">TPPEDLKDTTPLIVSEPASGELSPSVSGKRTPQIENLEGTTPLIVSEPDSGELLPFGSGKGTPPTEDIEDTAPLIVSEPASGELSPSVSGKRTPQIENLEGTTPLIVSEPDSGELLPFGSGKGTPPTEDIEDTAPLIVSEPASGELLPSVSGKRTPQIENLEGTTPLIVSEPASGELLLSVSGKRTPPIENLEDTTLLTPLEHASGEPSPSASGTGTPASDLSSADPNLVMSELDGVSSFQSGSYTRTRSPSTTDLTTSGTSTPTTLSIPVIFVSRAMIDIVELPEDIHTRNTAPKDDDSTDQSPFSHNDSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U135</accession>
    <name>A0A162U135_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_72065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289513.1">
        <property type="nucleotide sequence ID" value="XM_018442589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U135"/>
    <dbReference type="GeneID" id="29003495"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_72065"/>
    <dbReference type="InParanoid" id="A0A162U135"/>
    <dbReference type="OrthoDB" id="2429547at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15713" checksum="C0852DC9BCC70607" modified="2016-07-06" version="1">MFSNANLFSCNNIASSNTANSIIPAHNCSRPITGLIDNEVLLPPNMTIISRSESNETMSRLSVSGRPQFLTPRYKRCIVSNIKKTGGQRWMILLMMLVLTQERMSASLPCIKLCTAWIFFCCKPVSKSFLTKTHIVKRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U2W3</accession>
    <name>A0A162U2W3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_169836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD71923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289963.1">
        <property type="nucleotide sequence ID" value="XM_018436171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U2W3"/>
    <dbReference type="STRING" id="763407.A0A162U2W3"/>
    <dbReference type="GeneID" id="28997077"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169836"/>
    <dbReference type="InParanoid" id="A0A162U2W3"/>
    <dbReference type="OrthoDB" id="2447509at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="441"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD71923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="583" mass="65912" checksum="2D4F82C187651756" modified="2016-07-06" version="1">MAHQKYPLSKYTLITKYNIIAEIIALSHAAQYPAESSRAAASRPRVEAVQDSVAPIQPLSIDLSFTEQYTAESNRDLTAAFEALQVSDVERVLDLTTTTATATVIPCCSSCNRIGHQWSNNLQCPNNQRNRNFVPGQLTTTHNMAWHTTTPLPPAGQTFFDKIRWYNSTISFTSMGANINQSVANNIGGAYNYRIHETVCHKIVSVIPTTQAQMDQPKFAQIYIFDPASQVEHRQRNAPDLDRIILEKIQAVLMEVNPFVSLFRSIEQVACKNDGTANLIICLKADGPQDQQCYNAPTTEEVAVLIRDNETGSSRDIILHTHANGLQRINEYNCFYDALQYVLLFPLGDYDWTIVSYSATREKVSVMDWYANRLMYRPNSMHLLHQFGRLFQQYIVDMYTKVEHNCLDFLTQNQKKLRSKLYWGIQDALHLTDNNLANLGQQQAVYRVVKEAVEASPTTPRLYFVDGLGGTGKTFLFNAMLRKVCQQGKIALVVASSRIAALPLDVWLAFAMTINKSQGWTLDKVNLYLPDYVFGHRQLYVALSRVQTLNSVKIMVDMDSISTEAISNVYINNVVYNEVLSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U3M8</accession>
    <name>A0A162U3M8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_168554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291242.1">
        <property type="nucleotide sequence ID" value="XM_018435892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U3M8"/>
    <dbReference type="GeneID" id="28996798"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168554"/>
    <dbReference type="InParanoid" id="A0A162U3M8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="133" mass="15000" checksum="5AB1BA80EB4CCFF7" modified="2016-07-06" version="1">MDVNTVSSQCPGCSGTDHRRVNSLRYPSNRKVQTWSQIKNKCSKHLQHYATVFCSYEYQPVCIFVQINLSEIFHSHGLVGDLISCLVAGYPTFTSKQRTCEACIFLLFLFFKGGEITGKAINVDEDQRPSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U460</accession>
    <name>A0A162U460_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_145692</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291332.1">
        <property type="nucleotide sequence ID" value="XM_018431515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U460"/>
    <dbReference type="STRING" id="763407.A0A162U460"/>
    <dbReference type="GeneID" id="28992421"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145692"/>
    <dbReference type="InParanoid" id="A0A162U460"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF489">
        <property type="entry name" value="RING FINGER DOMAIN AND KELCH REPEAT-CONTAINING PROTEIN DDB_G0271372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="140"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="364"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD73292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="479" mass="55096" checksum="0E8BA5DFC837D009" modified="2016-07-06" version="1">MGTYPTSDKAYFTERIKASISMINPEWLPIVNEGKHSSRFGYDKFTILQNVQNYYLTDDQLTISISVAIEQTTKNLLNGPRSYPQLLALTFHDQDIKNLQDVTIHVFKNEKDEPDEKKSNLNHGSTGSTNENENKKVEDTEGTISNEEATLHGHNFILAAASPWFRDIFLSGMKESTENEVKIHGVDPKIFKLIFDFSYGNDIYIKDSTHGISIIKVADRLQFKRIKVYAFSCLRAQIKNSNMFDIWQASDLYDCDETRKLCEKYMRSNYADIFVSPEWLATSDVYALKAIKIDGLKGIVDETVFYKAVLARREAATQKVIDLQKLKEEESGDEVTKALPGTPTPSNVNIYEKIQKEIKDIKGAKGAKDTKGESKDNDYTTDTQTETETEKLERLENIRWERYIKEELEAIQKHFEVMICHIRFPQMDIEFIADTVEKEDAVMQIPGIKDILFESYRHKAFLGKRELSKKYQSRSIESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U760</accession>
    <name>A0A162U760_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SURF4-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_155389</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD74002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292042.1">
        <property type="nucleotide sequence ID" value="XM_018433399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U760"/>
    <dbReference type="FunCoup" id="A0A162U760">
        <property type="interactions" value="392"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162U760"/>
    <dbReference type="GeneID" id="28994305"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_155389"/>
    <dbReference type="InParanoid" id="A0A162U760"/>
    <dbReference type="OrthoDB" id="7859621at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002995">
        <property type="entry name" value="Surf4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02077">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD74002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="31110" checksum="5472D0C052CB1B1D" modified="2016-07-06" version="1">MDSIRTQIKAACEQAEHLIDQVKRPLKPHLPAVSRFLVVVTFFEDSFRIIFQWSDQKSYLEETRSFPSFIATLFLVANVVAMLGFSSTLIAKKHVSVAIAGLSVVMVSQALVYGLVFDLLFFLRNMSITGGLLLCLSESLLRQRKKSVFGSLPQLSEIERHMYFQLAGRVLLVLLFIGFVIHGQWSLTWAIVSLVGLAACVMVIVGFRAKWSATLLVSLLSVMNVLVNNWWSIQHSSPHRDFRKYDFFQTLSIVGGLMLLISIGPGNLSYDEKKEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U847</accession>
    <name>A0A162U847_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_167646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292262.1">
        <property type="nucleotide sequence ID" value="XM_018435682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U847"/>
    <dbReference type="GeneID" id="28996588"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167646"/>
    <dbReference type="InParanoid" id="A0A162U847"/>
    <dbReference type="OrthoDB" id="2365408at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="308" mass="35963" checksum="5A6215BE4C383E40" modified="2016-07-06" version="1">MSILKLPLEIMYLVANLLAPRYKLECVRVCILWRVVFEDSLWETIIINSPDDLKGVCNAVTTRTNRYNKAGNRTRRLYMGDSISAENNQLYSLQKSFPNLKYLIISRNSLRNEHNIAKRGWSFWRELTHLKLFMNESGTQNQIQKLHRLSLYLPNIKNLECFSTIKSRAPTYTLEDFEALHSNMPALEYLCLPANVAILSDRDIELIFSTKPAKSTTGIKFQITTIDIRWLCYFAKKYPNLSTFEWIEVEPFYRHYVFETEAAQILSKLPCAFTHVNKVHIRSSPKSEKVVSILYRALRQNKLLAKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U854</accession>
    <name>A0A162U854_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_124920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291193.1">
        <property type="nucleotide sequence ID" value="XM_018429018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U854"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF77">
        <property type="entry name" value="CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="264"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OAD73153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="455" mass="51391" checksum="709CA08DCF723582" modified="2016-07-06" version="1">MTLWKNKHTEFPTQEQLENLRLYKYAAEDKSYVTKYILRPYWDWAITLFPTWIAPNLITLIGLFFMLINVVFILIWVPDLGTEGPSWIYFSFAAGLWLYSTFDNVDGRQARRTGTSSPLGELFDHGCDALNCVYVVLLQSASLGLGHTGQVGILLVVTVVGFYLSTVEEYYTGVLYLGYVNGPTEGIIMSCLAFIVSGVYGAGAWQVELLDSTWFKWAGALLPQGTTFANMFVWGMVFFFIVTHCPMCLYAIHKACVEKNISSFRTFNTVLYPIISYSLVIYFWLSSPYSSLLQDQHVILFSLYFNVLFGLIASSIILAHLTKSEFPLFTGLLTMPWLMVVLVNSPAIFGTRVLSARSEYILLAFFFIISTIYYLFWVSTVIRAFCQFLGIRCLVIRRTKQSDSRILTSHQDESDSASLLDSQEEGITAAAHSLPSSESSVPKHHQSYNTFAQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U9Y1</accession>
    <name>A0A162U9Y1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_168872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Fungi incertae sedis</taxon>
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            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
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                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
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                <person name="De vries R.P."/>
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                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168872"/>
    <dbReference type="InParanoid" id="A0A162U9Y1"/>
    <dbReference type="OrthoDB" id="2286618at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="121" mass="13552" checksum="01DFD5E27A957456" modified="2016-07-06" version="1">MSGTLLEESGASIKSLTDPPKIELSEPCKDILNLISKSSASATCIKSQIRSFIGTNNSLDESEYADYYFAESTLHHFLQMMTSPRNPILFPMKERTAAPITTIYLLHAMFLSCNDLVSFHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UA88</accession>
    <name>A0A162UA88_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="9932926at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
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    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="126" mass="13814" checksum="4C358478DBAE742C" modified="2016-07-06" version="1">MDVAQSEQALQHMRRQSSVVGGRVKPLPQVFVGGDYRGQLEDVTRAVDDNQLSQLLRPRTRDIGRTKIATPVATASTIGLVSPPKTPVPRSAERSKTLIDEDDDALLKAIELELGDTDFSTLDLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UBB3</accession>
    <name>A0A162UBB3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_61007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292992.1">
        <property type="nucleotide sequence ID" value="XM_018440732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UBB3"/>
    <dbReference type="GeneID" id="29001638"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61007"/>
    <dbReference type="InParanoid" id="A0A162UBB3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="140" mass="16140" checksum="934683320105B059" modified="2016-07-06" version="1">MSPSQERNTHQTADTCNLHTATGTANYYISLPHRYQRDSTIKLWGTVKTDGVEILILKHIHDTIQESTYRRATIANTEDTFIIGAFSSEQQEIISDHFIFVDSGRYLSYCMCEDFTVAGPRGYWYTSSQQRVEPKRGKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UDZ9</accession>
    <name>A0A162UDZ9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_166788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293592.1">
        <property type="nucleotide sequence ID" value="XM_018435485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UDZ9"/>
    <dbReference type="STRING" id="763407.A0A162UDZ9"/>
    <dbReference type="GeneID" id="28996391"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166788"/>
    <dbReference type="InParanoid" id="A0A162UDZ9"/>
    <dbReference type="OrthoDB" id="2379842at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22744">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="42311" checksum="6DBB2D52B84B63C6" modified="2016-07-06" version="1">MKDKENWVNMYVYKHAHFGNRMSNRVESAHASLKHSFGTSPGKLKTVTLKVADRKHRLMVESLGEETKIVFDKVNATRLNDVRLKVCRFAMDQIKLELSKSIIPKKLAKECKCLIQYNYLLPCYHTLAKFDTIPISCIPRRWRKNYLEEEKKEQKKQKISSAKEQKAIKNIINLGSPCDPTLLTNLTIAPKHISTIFSPEADRNCGYRAIAMEVYQDQEEWSKVKDKMLETFLKHQNNYYHGRMEHGNMPASNNPLIHSLQDKCSPLPQQHWFGTIDHPQLVANIFSRAVAVYWNTPIETGYCLFVSFATLPEKVEPIIIILDINHFLLAKHKNTRNFCWPKINPFHKRIIQKHGLEDYSLMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UER3</accession>
    <name>A0A162UER3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_166930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293742.1">
        <property type="nucleotide sequence ID" value="XM_018435530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UER3"/>
    <dbReference type="GeneID" id="28996436"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166930"/>
    <dbReference type="InParanoid" id="A0A162UER3"/>
    <dbReference type="OrthoDB" id="10053513at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="367" mass="41911" checksum="C81C6F86FE2D8482" modified="2016-07-06" version="1">MQRLADDILMPPGYAVLSTKIESGFLYMKADEWQLWCLIYLLVVLKDALPEDDYKNWTLFLLGEFGKECETLYGESSITPNMPLHMHLHESMLNFGPVYAFWLYSFERYNGKLKNIKTNRCNGLEVTFMRVFLEKTFIGSFLRAYSTNLLSPLIEFLEGVAQVKSNSNSSSPLNLDAGHPPVLPFSLAMFQQAATNPWYNVTGSEALPPTTLPIKLQPLTMMKDDHYQWLFGFYVKAYRSTSVSFCVVGRIPIGEDVFVNNRIQKVKKILLLGQEYCSGKKKKRGSFVRVLFLERTNDDVSEFPGQIDHQPLADQGLQLWDKGFMEEDASCIVPVHRLHSCFALTTHKMQSGTQKHLVIPLPRKVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UPN6</accession>
    <name>A0A162UPN6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_142389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294923.1">
        <property type="nucleotide sequence ID" value="XM_018430802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UPN6"/>
    <dbReference type="STRING" id="763407.A0A162UPN6"/>
    <dbReference type="GeneID" id="28991708"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_142389"/>
    <dbReference type="InParanoid" id="A0A162UPN6"/>
    <dbReference type="OrthoDB" id="166568at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="59"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="317" mass="36656" checksum="4380012932ED8CA2" modified="2016-07-06" version="1">MNRIHALFYATPPRTTISCQKLSGWKENKKRLTVGLLCNANGTDKWSDILMIGRKEDQTYNSNVWMTQSIFYVFLRRFNHIMKAQNCKVFLILNNFSGHIVDYTPTNVELLFLPPNTTSYLLPLDGGIIWAFKAYFKHKQYAKAYQEAWESVSAKTIENCWNATIFRFIEDKDSEDINVNQAMIQQSLAEKVLVEGLEEALDKIARSGLLSLEDYPTSKSDPLYERQCTHRVINENEIADIVMEEYDADDNAANNNSNEEIAEVESAVPFKRTYSTLEKFECVCMLLDILEDKDIDRDFVSKVEDLRNKFQKTTNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UU04</accession>
    <name>A0A162UU04_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHYBLDRAFT_131460</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>glycerol + ATP = sn-glycerol 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296023.1">
        <property type="nucleotide sequence ID" value="XM_018429422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UU04"/>
    <dbReference type="STRING" id="763407.A0A162UU04"/>
    <dbReference type="GeneID" id="28990328"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_131460"/>
    <dbReference type="InParanoid" id="A0A162UU04"/>
    <dbReference type="OrthoDB" id="5422795at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000177">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000108">
        <property type="entry name" value="Glycerol kinase, glycosomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000756">
        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="13">
        <location>
            <begin position="5"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="14">
        <location>
            <begin position="265"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAD77983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="507" mass="56081" checksum="94F8C22880B27A2A" modified="2016-07-06" version="1">MPEFIGAVDQGTTSSRFLIFDKQGNLITHHQIELEQEYPRPGWVEHDPYKILESVLTCIENTIARFELMGHKISDIKAIGITNQRETTLMWDRKTGKPLHNAIVWSDVRTDELVHQLKKRPDSDIVVDRCGLEITSYFSAVKLAWLLKNDKNVAEAAKEKRAAFGTVDSWLLYNLSGGADGGSHCTDVTNASRTLLMNLKSLKWDPELLKFFDIPDHVLPSLVSSSEKYGEVHKGVLKGVPITSCMGDQQAALLGQKCFDKGDAKSTFGTGAFMLFNTGTTAVKSSHGLITTVAFQLGRNAKPNYALEGSVAVAGSSLRWLRDNLRLIDSMEQVSELASRVQDTGGVYFVTAFSGLFAPYWRDDARGTMVGLTSYTNKYHLARATFESMSFQTRAILESMNLDATVPLKVLKVDGGVSNSDVAMQIQADLLGIEVHRPAMRETTALGVAIAAGLAVGVWKGVHELDQVNQKGTTVFVPHLDKEAREEKYQAWRRAVEASYNWTDVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V397</accession>
    <name>A0A162V397_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_162708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297692.1">
        <property type="nucleotide sequence ID" value="XM_018434683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V397"/>
    <dbReference type="GeneID" id="28995589"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162708"/>
    <dbReference type="InParanoid" id="A0A162V397"/>
    <dbReference type="OrthoDB" id="10490059at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD79652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="40167" checksum="D81A148A9AF10AD6" modified="2016-07-06" version="1">MNQLKISLTSQNPVTDLEEDSIDCVPGNVSPFVEIDLGSPAKESRLDSLSNSIEIDTDDFKHDCQCGDRKCTIFDQRFLYEPRTQVQELQECQEDDISEHLSEAERGYEEEFSPNFIYTSGLTSSLQVESSAMHTRDQESEGDMVPSLGVSDCFPSLTDISSSPGIEEPPPPYFRDNSPSSTPAPPYRAQHIHRRETQDRELLLLRRAREDYIQSKIEEYYNHILFTNWRWFKIVIKQYHKCPYIGFEAKLFDIGACRLSKAFVSNQFHSWSAAFWITFFVFIGLSSPFIGLEQEPYWLSVPFCIYIMLSIPISMINNEREKRSKLYEEVCTAFARLQPEAPTERFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162VA28</accession>
    <name>A0A162VA28_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_73887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299233.1">
        <property type="nucleotide sequence ID" value="XM_018442939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162VA28"/>
    <dbReference type="GeneID" id="29003845"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73887"/>
    <dbReference type="InParanoid" id="A0A162VA28"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD81193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="122" mass="13864" checksum="F4035B91618BFD36" modified="2016-07-06" version="1">MLHEKLEEYNSAFEKIMEELEELEEPEMPEDPKSSALSTTDETPKKSRGQYQKPTDKDIKKLLYLYFIRGLTIKKASKIILALLSYNCIKGGEQIQMAMGANSVGNGRKFNFYGSQSDVNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162W9D8</accession>
    <name>A0A162W9D8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="12">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_156799</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="12"/>
    <dbReference type="EMBL" id="KV441009">
        <property type="protein sequence ID" value="OAD65595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283635.1">
        <property type="nucleotide sequence ID" value="XM_018433517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162W9D8"/>
    <dbReference type="FunCoup" id="A0A162W9D8">
        <property type="interactions" value="434"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162W9D8"/>
    <dbReference type="GeneID" id="28994423"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_156799"/>
    <dbReference type="InParanoid" id="A0A162W9D8"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000266">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 9 12" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="13">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="210"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="10">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD65595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="337" mass="35951" checksum="31BFB473D64305E5" modified="2016-07-06" version="1">MTVKVGINGFGRIGRLVLRASIEKEGVQVVSVNDPFIDLEYMVYMFKYDSTHGIFNGTVEAKDGHLVVNGHKISVHTEMDPTKIPWGKNGADYVIESTGVFTKTEKANAHLAGGAKKVIITAPSPDAPMFVCGVNLDAYKSEYKIISNASCTTNCLAPLAKVINDKFGIVEGLMTTVHATTATQKTVDGPSHKDWRAGRGAGANIIPASTGAAKAVGKVIPALNGKLTGMAFRVPTPDVSVVDLTVRLEKAASYDEIKKAIKDASEGELKGILGYTEDAVVSTDFLGDKRSSIFDAKAGISLSSNFVKLVSWYDNEVGYSNRVIDLLLHVAKVDGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162W9L2</accession>
    <name>A0A162W9L2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_176033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441009">
        <property type="protein sequence ID" value="OAD65645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283685.1">
        <property type="nucleotide sequence ID" value="XM_018437627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162W9L2"/>
    <dbReference type="GeneID" id="28998533"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176033"/>
    <dbReference type="InParanoid" id="A0A162W9L2"/>
    <dbReference type="OrthoDB" id="2290427at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="512" mass="58699" checksum="6A44BCB5A2F5E26D" modified="2016-07-06" version="1">MFSNSILDSYQCNFCKEHHPSLKKINNCRVQYFKNCCRRHNDIQTSQITYVPEQVSIVLNTVSNKSIIRENDTTNDDQTVNSFNNSDNNESMYSIEYDNTIEESVAMKDIEDVTTPMVYDFSQPLPTPSYNDAKNLKIIQIIKDFDISCKAHEKIISHFNKILATSTDITYRVCTPYLGKKLLKRFSRIEEKKYNVCCNSCMLFNDEHETKYSNCSKDCYKSTDDNNALVPARTMVQLPLVTVIRTLGSFCDFHEADESSQRELIGQSPLATLDAFSEPYFFALDEMHSICHGVAKQVWGLITGKYRKKHLLVLSVEVQKEIGAAMTLTRKTIPKSFYGAWRDVSKNTEYFKAVDWTHFLLELVEWNVYLETLLAKDKVDLNVFTINQNLLQHYPDMIEAFGLPRSYCAILVERAIDEYSNAIKREECSMIEAAIQTSHKVFDGCVIDSALNQNYVREAHNIRLQIQVDEKYNNGQMKPMVVHLADVKELVGLVKLGATINTITTTATTYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162W9S2</accession>
    <name>A0A162W9S2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_72358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441008">
        <property type="protein sequence ID" value="OAD65725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283765.1">
        <property type="nucleotide sequence ID" value="XM_018442643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162W9S2"/>
    <dbReference type="GeneID" id="29003549"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_72358"/>
    <dbReference type="InParanoid" id="A0A162W9S2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="306" mass="35410" checksum="67AE4EFBA464D690" modified="2016-07-06" version="1">MVHRSILSHPNLNNTLLNPHILIETYDNVSNPLTPTLIPVFRDSPQHQGYKTYSPVLSPSISIPEAVPVLSPDPSISSGSKYQAGFIDDIVARSEYAYIIPISGSRNVPLWQCINIKETFLHENQALTTDKYTFDDTMYISEPNALSNNPRMELYQDTYLPSVLKVSQQIDSISTSNLSRKQTRFVNFLPESFSEDRNHRIGQNTKSRKNQSLFRPYSQYSMNKKKRKLREECKRIYDCDKCNYWSDRRGNLKRHSAHHDKSVKKAKCPTCKKKFSSKFNVQRHVSSSFNTFVVIGEHYVDKYVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WH95</accession>
    <name>A0A162WH95_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_151708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441025">
        <property type="protein sequence ID" value="OAD67105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285145.1">
        <property type="nucleotide sequence ID" value="XM_018432728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WH95"/>
    <dbReference type="GeneID" id="28993634"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151708"/>
    <dbReference type="InParanoid" id="A0A162WH95"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="148" mass="16601" checksum="C65E6043587B9BAC" modified="2016-07-06" version="1">MLTIKNPQTNNNQTTFEGVVSESVSAFSFLGTSEGTYRRDKQCVESREAQSVQNIGNDDSQDIPRPDKNSHSESSALSAKEIKSTMSLYLGRGNPQTGADMYYITEKIVFHVINNTFDALINKKDVIPSWGNLKSFQENYLVHKNCDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WHL6</accession>
    <name>A0A162WHL6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_174549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441025">
        <property type="protein sequence ID" value="OAD67165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285205.1">
        <property type="nucleotide sequence ID" value="XM_018437280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WHL6"/>
    <dbReference type="GeneID" id="28998186"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174549"/>
    <dbReference type="InParanoid" id="A0A162WHL6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="158" mass="18233" checksum="9D144D2A3583C94C" modified="2016-07-06" version="1">MTMVIRYFVWTRKDCTSVYMSYCKQARCKEVPGGQPLSTLVPLSDHDLTVKKLYLKKLCRMDAFGEADKERWIAYLPVSLRESFKWDNQIYKRRMEKKNKTQQDISDSSFSFLNVSKTGDAESPIMTDILQFSSKDAGGASFKREAKEHILTLLISPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WWD6</accession>
    <name>A0A162WWD6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_114596</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289265.1">
        <property type="nucleotide sequence ID" value="XM_018428402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WWD6"/>
    <dbReference type="FunCoup" id="A0A162WWD6">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162WWD6"/>
    <dbReference type="GeneID" id="28989308"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_114596"/>
    <dbReference type="InParanoid" id="A0A162WWD6"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017069">
        <property type="term" value="F:snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000132">
        <property type="entry name" value="Small nuclear ribonucleoprotein U11/U12 subunit 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952:SF6">
        <property type="entry name" value="U11_U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 35 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="46"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD71225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="161" mass="18285" checksum="0D6F99F94461EA46" modified="2016-07-06" version="1">MWYAKEYHPIQVGSIDGTDKIPHDAAVERAQQVKYRPPKLSTDPTKTIFVGRLNFDTTEDTLNQHFGQIGSIESLRLIRNQVTGASEGYAFITYDTTEAAKEAYQTAHQTIIDNHVILIDYERGRIMEGWVPRRLGGGFGGKKESGQLRFGARDRPFRRPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162X1B3</accession>
    <name>A0A162X1B3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_146948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD71965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290005.1">
        <property type="nucleotide sequence ID" value="XM_018431763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162X1B3"/>
    <dbReference type="GeneID" id="28992669"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146948"/>
    <dbReference type="InParanoid" id="A0A162X1B3"/>
    <dbReference type="OrthoDB" id="2404451at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="429" mass="48690" checksum="CCAAA3F38CF25424" modified="2016-07-06" version="1">MMNQWIERGVLGDRDLTAMQKIADKMIVLRGYTALKSKIGKKFAFMKADEWKSWVLIYSPVVLKLVLSSLHFNNWIDFVHACCHLVKPSITFDDINTAHRHLEKFCEKCNEIYTVTILTYNMHLHLHIQETILDFGPVYSYWLFAFERYNGLLKNISTNSKNGFEATFMRCFVEDIYKSDFVNSALTCPTQAPFLSVFTLPSASSTIVQPPFILQAFVDSSETTRIPILGNKPLPPTFFPLSVSKPSSMSDINYPHLLEYYKLAYLTPDLIHYQNAAASPFFVNNQIIKLKSINILGQVYYGNNGTTGRGSYVQSLFLGSDGSTETTFTCQIKYIFIHSFTPPSMSPYYEADSTHHDQHIFAFVNWLPLLGDESQEKDGVDICGSTPLPSNYHSILPVHRISLEVAIANHTTGLVQKKLVIALPKKLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162X6I5</accession>
    <name>A0A162X6I5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Very long-chain fatty acid transport protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Very-long-chain acyl-CoA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PHYBLDRAFT_169064</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities. Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290845.1">
        <property type="nucleotide sequence ID" value="XM_018435999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162X6I5"/>
    <dbReference type="STRING" id="763407.A0A162X6I5"/>
    <dbReference type="GeneID" id="28996905"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169064"/>
    <dbReference type="InParanoid" id="A0A162X6I5"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000019">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="FATTY ACID TRANSPORT PROTEIN 3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="18">
        <location>
            <begin position="60"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="19">
        <location>
            <begin position="522"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00078285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OAD72805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="645" mass="72464" checksum="632DEA3433D74583" modified="2016-07-06" version="1">MSSAALIPVAAGMGSVFGSMYLDARLLLGKDLVQIRAGGLSNIHHALWTYRDRLHYYYRFKDQAKAHPNRVFLYFEGKEYTLRQLEKASNRMAHWLLSLNIHKDGRTMKIGDIELVDVVCMMHQNHPTFYIVLLAISKIGAIPALINTNLSGDSLAHCVTVAKASMLIFDPVYETQVESISAKLSEQNIRLYAYGESTETGEIPDLHIASAVTPMVLESFSERDTSESYLKGINLQDPAYLIYTSGTTGLPKAAISQHARICYGMSMYSKTAGIKENQRVYCVLPLYHSSGLIVASSVTLFAGGSIVLGRKFSASRFWNDCVDYKVDVFSYIGEFCRYLLSQPPHPLERKHHVQLVYGNGMRPDIWNKFRDRFNIPKICEFYAATEAPTSMFNVNSNDFGAGAVGFRGRLMRSFRRELKIIKIDPITEDPLRGKDGFCIQCPYGEQGELLVMIDEASPVQFSGYYKNNEATTKKVLTDVFVKGDAYFRSGDLLHVDADGFFFFGDRVGDTFRWKSENVATTEVAQAVSTFPGITEANIYGALVPNHDGRAGMAAIVIGQEGIDFKAFYQHLSKKLPRYAIPVFIRFVPSMEMTGTFKQQKVEYRNQGIDLAKIPEEGSIYWLQKDTYVPFTKEDLNKLEAGKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XB69</accession>
    <name>A0A162XB69_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tubby transcription factor, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_145121</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TUB family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291685.1">
        <property type="nucleotide sequence ID" value="XM_018431369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XB69"/>
    <dbReference type="STRING" id="763407.A0A162XB69"/>
    <dbReference type="GeneID" id="28992275"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145121"/>
    <dbReference type="InParanoid" id="A0A162XB69"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.90.10">
        <property type="entry name" value="Tubby Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000007">
        <property type="entry name" value="Tubby_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517:SF7">
        <property type="entry name" value="PROTEIN KING TUBBY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517">
        <property type="entry name" value="TUBBY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01167">
        <property type="entry name" value="Tub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01573">
        <property type="entry name" value="SUPERTUBBY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubby C-terminal" evidence="3">
        <location>
            <begin position="69"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD73645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="323" mass="36920" checksum="A1BF1B9AB0722512" modified="2016-07-06" version="1">MPITHPQLSTSTFGLSEFDANDDRENNDAQIAPLQEPTTVRVERPVPPIDFTLSRPISSLKELNQLTFRPAALNTRLTCRICRYRDGLDKLSPQYQLFLENVDTGEMQYVLTARKKRKTQTSYYTITGDYLDVSTSEVGVPKSVVLGKVRSNFLGTTFVIYSHGRNPFNSNGSEKNDLPVREELGAVLYDPNILGFKGPRKMTILTHTLTRDGKRPEFRPTEESETLLCKYRDGNARDLLILHNKSPQWNEDTQSFVLNFNGRVTQASVKNFQIVHDNDLDYIVMQFGRVERDYFTMDYKYPFCLLQAFAIALTSFDAKLACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XH92</accession>
    <name>A0A162XH92_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_167207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292905.1">
        <property type="nucleotide sequence ID" value="XM_018435593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XH92"/>
    <dbReference type="GeneID" id="28996499"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167207"/>
    <dbReference type="InParanoid" id="A0A162XH92"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="14260" checksum="3B5B88ADD7A1C7E6" modified="2016-07-06" version="1">MPSSCHIAKKYSLQLNTAMKMMNNPLSNMPCIKNYHPMLPSLTCQRKSEQTPYLTFSVSFCSTHLFLVFSIKQIQYYTERHASFSDRYIAKLKKRLRVKSRKIYNKTFSAPRDTKKINLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XZ84</accession>
    <name>A0A162XZ84_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_185488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295465.1">
        <property type="nucleotide sequence ID" value="XM_018439083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XZ84"/>
    <dbReference type="GeneID" id="28999989"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_185488"/>
    <dbReference type="InParanoid" id="A0A162XZ84"/>
    <dbReference type="OrthoDB" id="2265046at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007840925" description="Secreted effector protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD77425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="16358" checksum="E8C4A5A1773E9FAB" modified="2016-07-06" version="1">MFHRSSILMQILFILCTLLLLVSCRPYEIRKSGGAESLELSRPSQFQMDVYSRPSRRGTVQRIRSKRKRSVSTPCWNLQSKHVGSIDLNDPLTKITFYRSPECQGAPVRVLQGTSTKQLNIKARSVKVVRIRPIYFSTPEDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YGH2</accession>
    <name>A0A162YGH2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_61556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298545.1">
        <property type="nucleotide sequence ID" value="XM_018440822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YGH2"/>
    <dbReference type="GeneID" id="29001728"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61556"/>
    <dbReference type="InParanoid" id="A0A162YGH2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="125" mass="14111" checksum="47B053050AE6885E" modified="2016-07-06" version="1">MDMFLTGQRLPNFSQKDRRITIEIRVSRNCVTAILHNVFTHLMSDFVFELNVHLYCPSIALASTMVNKGEATLVGDLGKMFGGLKGCFKFKDKCPYSIPQLGLNIIIFLQNIPLDLHFFPVTMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZAS6</accession>
    <name>A0A162ZAS6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_153399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441010">
        <property type="protein sequence ID" value="OAD65501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283541.1">
        <property type="nucleotide sequence ID" value="XM_018433137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZAS6"/>
    <dbReference type="STRING" id="763407.A0A162ZAS6"/>
    <dbReference type="GeneID" id="28994043"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153399"/>
    <dbReference type="InParanoid" id="A0A162ZAS6"/>
    <dbReference type="OrthoDB" id="2289470at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="41974" checksum="BF6982A475F6AC9F" modified="2016-07-06" version="1">MEGVPYTSWVHADRLKIVKSDDFNRTWYHPTPAHAQMHRDLAIDSSSTLPFSLVTTSMVDRGLSTVLEGGDVGHYFDESVKSEDGQPSASLPAPQSTADLETATFTWATKTSLILPAKTLQVPSARRVAASQRLFSDKTGPDGFEYIYILLSRRITHSEVRRSPRTLGVDTDCLLDINFPAHGVIGILVHVQYLEKFKSQLASAKVSLVNNFDSLDPKNVADLKFANLFVSVAHFFVQSRWIGLEEIPARPVAEHFGLWNANGLQPRAIKDVLNHSRLPTSWSQFHLYGSPVAGNYRRSMGVSLLVFPSCPYAVTQIPMPNNYALAVKIGTLRLICLYLPLSMLTHEALDILSAIPLTDDTIICGDFNARLDSVHWKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZCA0</accession>
    <name>A0A162ZCA0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_119732</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV441027">
        <property type="protein sequence ID" value="OAD65801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283841.1">
        <property type="nucleotide sequence ID" value="XM_018428702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZCA0"/>
    <dbReference type="GeneID" id="28989608"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_119732"/>
    <dbReference type="InParanoid" id="A0A162ZCA0"/>
    <dbReference type="OrthoDB" id="1515171at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="40"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD65801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="105" mass="12416" checksum="1A4B80ED87572F5D" modified="2016-07-06" version="1">MFWSDELQHSIINKRIEDRTNFPSWICFVNGILIGLEYKPTWKGKDFYSQKSYYSISVTIVCDDKKMIYHYYTERAGCSHDACIFANSQLGRTPGRFFLGDQYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZHS2</accession>
    <name>A0A162ZHS2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_174872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441000">
        <property type="protein sequence ID" value="OAD66851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284891.1">
        <property type="nucleotide sequence ID" value="XM_018437364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZHS2"/>
    <dbReference type="GeneID" id="28998270"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174872"/>
    <dbReference type="InParanoid" id="A0A162ZHS2"/>
    <dbReference type="OrthoDB" id="2289025at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="148" mass="17495" checksum="A08FBBA44079F002" modified="2016-07-06" version="1">MFWMLKLKNLKELSIIWFTTYQTDSGQSSRLVVSWKIAALIEEDPTFNSTNRILLVIRKIAEVLPRFIIEDGPQETELITQYLHPALVPLFENIDELHVTFKWTPRQFHEIKFMTMTWPFGLSRNNNNEKEMWCNAMQCNVIGTCEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZMN8</accession>
    <name>A0A162ZMN8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_150953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285911.1">
        <property type="nucleotide sequence ID" value="XM_018432580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZMN8"/>
    <dbReference type="GeneID" id="28993486"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150953"/>
    <dbReference type="InParanoid" id="A0A162ZMN8"/>
    <dbReference type="OrthoDB" id="2218707at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="179" mass="20197" checksum="6E5FC343BD67AA8F" modified="2016-07-06" version="1">MRVKAITLGTTHPSALSLYMIPIQDNQPLDFFSLDDLRYIFTIIHSPTSEEIHSITRLVQSSPESICTDQNGHIYLQSQLVIAIACRLQLYALAELCRLSHKDLLAGTANPLLQSLSFTLKPNTHPHITEHTLILDWSITDATLSHLAHLFIEQHHISSDDGEFTQESVSDTEQTLLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163A641</accession>
    <name>A0A163A641_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GATA-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_126072</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289361.1">
        <property type="nucleotide sequence ID" value="XM_018429078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163A641"/>
    <dbReference type="STRING" id="763407.A0A163A641"/>
    <dbReference type="GeneID" id="28989984"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_126072"/>
    <dbReference type="InParanoid" id="A0A163A641"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="161"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="227"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="117"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD71321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="282" mass="31281" checksum="92FF673903190D77" modified="2016-07-06" version="1" fragment="single">MTESGNYMLGYPSERFFDKEHLVQMLSDACRSNHPSPSPSSDAQTVFSSFPSPISSTAGAGAGSLNNSPTLSTINPIHLHASNSFLDTFPNIYHHQPNQVQPTESLDQYVQFEDDSMASSTTTTTTNNTNNNTSNNNDSQSVSPKETNQFCRSDPATPDPTVRQQECFNCHVTKTPLWRRTPDRAHSLCNACGLYYKQYGNHRPLHLPQQTNTATTVTTATTASVADSPSQQCANCLQTNTPLWRKNDRGESVCNACGLYAKLHHRDRPAAMRKPTIQKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AMY1</accession>
    <name>A0A163AMY1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_145014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292621.1">
        <property type="nucleotide sequence ID" value="XM_018431346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AMY1"/>
    <dbReference type="STRING" id="763407.A0A163AMY1"/>
    <dbReference type="GeneID" id="28992252"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145014"/>
    <dbReference type="InParanoid" id="A0A163AMY1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="387" mass="44365" checksum="76E59855E855AB46" modified="2016-07-06" version="1">MNMFLYVINPTSECLDHHKLYVALGGKFCPTINDSRRNAHGIHLQDQLKHHGFPFALDVSLEDIDKAICASRTDIPADFMGTWRSWKESNGKRKAVDWTDFLLFVVPTIVIDHFVFDHIKAAVMNLVTACRIAQQAIGCWHAFLRCEIKEKRLKPTIFVMNQHMLVHLGYMMWEMGPLQAYSCTPIKRTIGVYSMAIKLRKKPGKNMENLLLRKAAINHCLGCRPVICVTNDKRTSNFEVAKCQDLVHSLVPFWAREDIVSFEENNEVVCTNKMWKDSVVYRVWSSVDSRHGRANNLAVLNDAREYGFILKFFSQTVNRVIRLFAAINCLSDVQRVNQDLFPAWDSLAPGVMKVVDVKSIEGIAGFIHNPNNKAIWHIIWSSPKYNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B176</accession>
    <name>A0A163B176_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_17364</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295741.1">
        <property type="nucleotide sequence ID" value="XM_018437076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B176"/>
    <dbReference type="STRING" id="763407.A0A163B176"/>
    <dbReference type="GeneID" id="28997982"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_17364"/>
    <dbReference type="InParanoid" id="A0A163B176"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD77701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="143" mass="15571" checksum="90E7C0B701F0425C" modified="2016-07-06" version="1" fragment="single">MPSDPEHPPRESPDPKPKGRLACHDPNRTDKAGRTKLFACTTAGHLDKVREWVSRGADVNFKDNAGWTPIHEAAIKGQCEIAEYLIECGADINVRGFGNDTPLHDACSNGFVDCVRLLVNKGADVFALNADKQTPLDVCESTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B6U8</accession>
    <name>A0A163B6U8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_130779</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296621.1">
        <property type="nucleotide sequence ID" value="XM_018429385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B6U8"/>
    <dbReference type="STRING" id="763407.A0A163B6U8"/>
    <dbReference type="GeneID" id="28990291"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_130779"/>
    <dbReference type="InParanoid" id="A0A163B6U8"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF4">
        <property type="entry name" value="CDF DIVALENT METAL CATION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="7">
        <location>
            <begin position="10"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="8">
        <location>
            <begin position="213"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD78581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="304" mass="33963" checksum="51CD774D6555BB0C" modified="2016-07-06" version="1">MWIVHLAINLSFVANIMLFAAKLFVAFYSGSMAILASAFESFLDIVSNAIIFFTVRIIRHKDFYTYPVGKSRMEPLGIVVFAVIITTSFSQVLISSVERLADPEKVGEELDLSLSALLLLGANIGVKAILWGWCATIKGSSSVEALAYDHENDVVFSIASTIFPLVGKCIWANMPWLDPLGAIILSLYIIYEWMSILLDNIKKLTGQAATTDDIKQLTYMAYRFSHKIVEVDTVRAYYIGDRLLVEVDIVLPPNCPLQEAHDVGEALQDALEMMDNVERAYVHLDYSSQHAIEHRRALETGYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163D2I4</accession>
    <name>A0A163D2I4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_73017</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286290.1">
        <property type="nucleotide sequence ID" value="XM_018442761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163D2I4"/>
    <dbReference type="FunCoup" id="A0A163D2I4">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163D2I4"/>
    <dbReference type="GeneID" id="29003667"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73017"/>
    <dbReference type="InParanoid" id="A0A163D2I4"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="3"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="133"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD68250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="346" mass="37427" checksum="4A81387319E8E996" modified="2016-07-06" version="1">MSLRWGILGTGNIATTFANGLKQSPLNSLVAIGSRSDASAQAFGQAFGVTKAACYGTYDALLADPNVDIVYIATPHPQHCELAIKTAKAKKHMLVEKPMAMNEREVQLILDAAKENDVFLMEAYMYRCHPQTQKAAEMIKQGVVGEVKLVKASFSFEGYSLGPSSRLWRNELGGGALMDIGGYPLSWARLIAGAAQGSSPLHPTILKGVGNVQKDTQVDEWAMASLGFENKIGAQLFVGVFADADCSVEVVGTKGTLRVPNLWRPDLAVLGPTQIEVSEHGKAAAITPIVLEQTNLFTFEAEAVAKAVLSGKKECDFMTWEDSLSQVRSMDQWRKEIGLVYSADKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DEV3</accession>
    <name>A0A163DEV3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_170867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288820.1">
        <property type="nucleotide sequence ID" value="XM_018436438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DEV3"/>
    <dbReference type="GeneID" id="28997344"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170867"/>
    <dbReference type="InParanoid" id="A0A163DEV3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="150" mass="17784" checksum="8169FBF044B41332" modified="2016-07-06" version="1">MVYLYKARIQVTLEPRNKINRLRIAYIYLQEVFFDLNDLLIYLLDCQRACLVNFEENTPYWGYSDMWSDILSACVSDKDKVPELVLQTNIEWILYSNKFAIPHLALSFVPKTPRKRKATVVVPYGKINVSFFKKKHEVDRLFPLGQFKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DFV0</accession>
    <name>A0A163DFV0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_77558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288990.1">
        <property type="nucleotide sequence ID" value="XM_018443270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DFV0"/>
    <dbReference type="GeneID" id="29004175"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_77558"/>
    <dbReference type="InParanoid" id="A0A163DFV0"/>
    <dbReference type="OrthoDB" id="2158812at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="258" mass="29210" checksum="F2E4A881D953C73F" modified="2016-07-06" version="1">MNAHMNTFAADAPIRFNYKINLIAGRDRLLVESLIHRHPSYAGHGQSGAAWDEILKKVKDAGGKGNEIGVSTLKQRHKNLVKQFKARQTQEKKMTGSNESYSDLDQLLFQLVELEAEGDRGKAMKKQLASEEEVQKQAAAGKVVERATLLKSNNPLRVVEQKKWTDKVEGSSSGHLVGQSTADFSDAREMLKSFRDELSSMVAGISDGEVLTSMRRLEENVERGFLAIETRQRTLEQRQTLLEERQARFEYNMQRYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DMC3</accession>
    <name>A0A163DMC3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein eL24-related N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_125461</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290350.1">
        <property type="nucleotide sequence ID" value="XM_018429043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DMC3"/>
    <dbReference type="FunCoup" id="A0A163DMC3">
        <property type="interactions" value="594"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163DMC3"/>
    <dbReference type="GeneID" id="28989949"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_125461"/>
    <dbReference type="InParanoid" id="A0A163DMC3"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL24-related N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD72310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="153" mass="16980" checksum="4C61807F75930A3C" modified="2016-07-06" version="1">MKLEICSFSGHKIYPSKGKTYVRIDSRSFRFINGKSESYFLQRLNPRKIKWTVIYRRLNKKGITEEIAKKRSRRTVKHERAVAGVSWDAIRAKRNQKPDARAAARQAAIAKSKEAKKAAAATKKTTTGSAAQGAKVSKQGAKGFAPKAAATSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EE83</accession>
    <name>A0A163EE83_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_157470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296200.1">
        <property type="nucleotide sequence ID" value="XM_018433622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EE83"/>
    <dbReference type="STRING" id="763407.A0A163EE83"/>
    <dbReference type="GeneID" id="28994528"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157470"/>
    <dbReference type="InParanoid" id="A0A163EE83"/>
    <dbReference type="OrthoDB" id="566238at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="29"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="306" mass="34028" checksum="CD996A9C0312F2EC" modified="2016-07-06" version="1">MSPSHQPIHLIESQALRNILIKQHKIDRLERDMILVDVREPSEIENGGKIQGAVNIPYGLSKTNPALFRAVLNDLDKERWTIFQCRSGRRSDFTALEALNLGFTRVSDLKGGALEWEALGFPLQKFNNNHSPWVHSIATNNSNTSHIITDLVTKEAIIVNPSLETGVGVDPMATANKILAFVAEHQLNVKLILDSQNFNSAAYYLNESLDTHPPVGLDSVARENKENLTWKLGQHIDCSAYVTSDTTTFMFGDCLFIDQTISTNNVVLSIDTRIYARDVALKRGAVKKPTKEYLANGDALLIPGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ERQ5</accession>
    <name>A0A163ERQ5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_138658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299150.1">
        <property type="nucleotide sequence ID" value="XM_018430045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ERQ5"/>
    <dbReference type="STRING" id="763407.A0A163ERQ5"/>
    <dbReference type="GeneID" id="28990951"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138658"/>
    <dbReference type="InParanoid" id="A0A163ERQ5"/>
    <dbReference type="OrthoDB" id="5599418at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="1">
        <location>
            <begin position="36"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD81110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="79" mass="8962" checksum="4E5E4A8089EC17D1" modified="2016-07-06" version="1">MAWPTPKTCRDIQSFLAHATALLDALQSANNIEHIWNDKHQRCFEQLKAIIQSNPVLQHPDLTQLFLVATNAFKLGIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JAB5</accession>
    <name>A0A167JAB5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleoporin Nup82</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_79908</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441009">
        <property type="protein sequence ID" value="OAD65589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283629.1">
        <property type="nucleotide sequence ID" value="XM_018443524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JAB5"/>
    <dbReference type="FunCoup" id="A0A167JAB5">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="GeneID" id="29004429"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_79908"/>
    <dbReference type="InParanoid" id="A0A167JAB5"/>
    <dbReference type="OrthoDB" id="341482at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037700">
        <property type="entry name" value="NUP88/NUP82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257">
        <property type="entry name" value="NUCLEOPORIN NUP84-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD65589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="782" mass="88999" checksum="37EC8F14FAD8C509" modified="2016-07-06" version="1">MSTSWPTSLSSHPIFRKSDKSLLYTANILATDVPKQSLIAVIFDIYLLVAVSNEIRILNLYKFNKQQETAEEPIKYNVVSLPLIDFEIVQILPCSETGVLVVAGEYKLAAVQLQKAILDQDKDHTDPFTCFIGQPTYYTGFNNVRIIKMEWHPLSTTSLHLMILDNQNILRMFDIGTNLNEPEQTFDLSPPNTSSKSLVSDFKKNMRVTSFTTGGESSASKQWEPLTVFYTLDNGHIYALCPVLPNHSKIKARNWLRILDLTETKLMNNKKEAFLLTESFYIKENLIRLQLEWLQRYTLPCSLYDLEDNDIYIIYDAAAVKHEFKLQKQGPFVITGATRAASPTTDILFTHKPAINVLAIAYAHGAVGVHFLSKDIDAQWNFSAENINTCSPYKVQSRPDLFFAKNLPTATLYETIHFEPTFTSNVKLSVRLIKDPLSVYKIYCQHSGGIHALSFKPWMHKIQELDDQYEANVLRDEIMSLVESWPVEEYPTIVSRLIYSGDSKRRVPMLGAVITTKAIGYSLIGYFWDSRSAVLPLTAATVPSTGFETTDEDENEDESNLTYVAALTSHLENIKLFNNQNELNENCRLAFPLFRISDDLADCLASNILPIYVLPKDIGTSKPECYLDKLTANAAKTLSVIQKLDNTATEIEKRVAAQKLVYENQTNTLEKLSSKLDNILSVETVKVYREKLENAVKNYSHLVERVKTLSRSMADIHSPDVTVEELELFKQISILEYEIDKRQNDKDEFKKAIAKLHWIYSVESKKASKSKESRNLWFSSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JC82</accession>
    <name>A0A167JC82_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_119862</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441008">
        <property type="protein sequence ID" value="OAD65696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283736.1">
        <property type="nucleotide sequence ID" value="XM_018428715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JC82"/>
    <dbReference type="STRING" id="763407.A0A167JC82"/>
    <dbReference type="GeneID" id="28989621"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_119862"/>
    <dbReference type="InParanoid" id="A0A167JC82"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="13"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="485"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="502"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="538"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD65696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="552" mass="60789" checksum="249A296757D2CE97" modified="2016-07-06" version="1">MAKLKGKALFAASTLLAAIGFLLFGYDQGVMSGVVSNQRFKDTMGNPDSALMGAIVALYEIGCMAGALSTGRIGDWLGRRKTIRLGCVILIVGAVLQTAAVNSAMMIVARIVTGVGNGMNTATIPVYQAELSPPKSRGTHVAFEASLLAVGVAIAYWIEYGLFFVDGEVAWRFPLAFQMFFAIILCVASFVLPESPRWLQSHGYEEECKVVLARLWTDEDVSHPRCIAEWEEIRDGIELERREGVSSYKELFKKGRLNNRYRVLLGMGGQLIQQFGGINVISYYLTDVFIQAGMTTEMAMLMTGIDGIVYFLGACTPIYTIDRLGRRKLMYLGLIGQAATLLIVGGCQYLVENGNTNASPGVIAFVMIYNFVFGAAWLGLAWLYPSEIFTTGLRAKGNSMSTAANWLGNFVVAMIAPVLFEYAKYWTFLMFGILNVVFLIPIYLWYPETKGKSLEEIEVLFSSEEVQEDSRSLSHIGSVSAYDSKRDAESLAQRPHSSRMYSFGSRPGSRRMPSSFSVVHPKSEKPNPNSAAGQVKQEYTKGDDEVKGPNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JDS3</accession>
    <name>A0A167JDS3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_71692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441027">
        <property type="protein sequence ID" value="OAD65788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283828.1">
        <property type="nucleotide sequence ID" value="XM_018442525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JDS3"/>
    <dbReference type="GeneID" id="29003431"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71692"/>
    <dbReference type="InParanoid" id="A0A167JDS3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="126" mass="14670" checksum="DB7124D2909C95FA" modified="2016-07-06" version="1">MFPSIQMHNTDCYCTRYHNNDQEVFRVLRRTAQRHNKRTRFEAEKRSMEVDTEIIPTYQSDSVEAMDSQANSPISDAVSMFDNDVFVGNDYNGDESDRTNDNDSDDNGEEDTAEIYVEEFNNEGQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JMW0</accession>
    <name>A0A167JMW0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_102763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441004">
        <property type="protein sequence ID" value="OAD66336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284376.1">
        <property type="nucleotide sequence ID" value="XM_018427738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JMW0"/>
    <dbReference type="STRING" id="763407.A0A167JMW0"/>
    <dbReference type="GeneID" id="28988644"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_102763"/>
    <dbReference type="InParanoid" id="A0A167JMW0"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF2">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="1">
        <location>
            <begin position="14"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="131" mass="14944" checksum="7C985FEC7159C9CF" modified="2016-07-06" version="1" fragment="single">ALLSHIAREIYRRLQTGTLVKNGIVYHDVFSGKEATDCMAVILNHKNRNLALLVGRALDSQGFINEVNYEHRLRDSPGALYRFRSHHGLPVEMIDEEQRIKTKDDVLMDTKRVNGIFTVLTECYSPTCTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K436</accession>
    <name>A0A167K436_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_85770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441025">
        <property type="protein sequence ID" value="OAD67236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285276.1">
        <property type="nucleotide sequence ID" value="XM_018443617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K436"/>
    <dbReference type="STRING" id="763407.A0A167K436"/>
    <dbReference type="GeneID" id="29004522"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_85770"/>
    <dbReference type="InParanoid" id="A0A167K436"/>
    <dbReference type="OrthoDB" id="264917at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF42">
        <property type="entry name" value="LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN C14F5.10C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="99"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD67236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="469" mass="52673" checksum="CE1DABC2F2F1E043" modified="2016-07-06" version="1">MVKFVYLSCYVCKDPLVDPVALSCGYTVCRDCVDIIPQKVFHCPVPDCNQPSHLFGRSLHPDTTVFAISRLITNTAHPSSELSSHLTQKSSALSTIMECMHCHDPFSDPITTHCGHTFCRLCALFLKATKNHCSACKLPLPRYTSLVNQPSNRMISQLSKKLFQDTQRRTSRDLGSSNRHKSVVLYVSQAIILPHQRFRLPVMPEDRSRFQTCLLKSSRYDNVCIGMVYCGTKLSLMGTLVKILAVEHRSDGILLVDLAGLDRFQVLDHSPYIKEDTDTSLLATINILPEIHLSEDCVGFQTITDTELSSQSSLTEDETNEESSLSVDVVEIGRPLWAADIMPQQDDTFNSIDLPDDETESMTITIRDFIHRLASPPVTGCKASTEGLFGPTWFTNIQILHGDMPPLSRSAALCWWVSFVLPILNKDKLRLLKTLPLKSRLALVLSWIDRLEQQWTFRSDSLPVSTKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K9G5</accession>
    <name>A0A167K9G5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Iron-sulfur cluster biogenesis chaperone, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_128104</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Assisted by the DnaJ-like co-chaperone jac1 and the nucleotide exchange factor mge1, it mediates ATP-dependent Fe-S cluster transfer from the scaffold proteins isu1/isu2 to grx5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285578.1">
        <property type="nucleotide sequence ID" value="XM_018429201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K9G5"/>
    <dbReference type="FunCoup" id="A0A167K9G5">
        <property type="interactions" value="838"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167K9G5"/>
    <dbReference type="GeneID" id="28990107"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_128104"/>
    <dbReference type="InParanoid" id="A0A167K9G5"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11733">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000007">
        <property type="entry name" value="Heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="643"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="538"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD67538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="664" mass="71449" checksum="A70A9E8A40C159EC" modified="2016-07-06" version="1">MYNLAQLSRSRAIPSLARNSGVVATLARPYSSKINGPVIGIDLGTTNSCVSVMEGKNPRVIENAEGARTTPSIVAFTKDGELLVGQAAKRQAVVNSQNTVYATKRLIGRQFKDSTVQADLKAVSYKIIPHTNGDAWVEAQGKKYSPSQIGAFVLGKMKETAEGFLGKKANHAVVTVPAYFNDSQRQATKDAGKIAGLDVLRVINEPTAAALAYGLDKSEDRTIAVYDLGGGTFDISVLEIQNGVFEVKSTNGDTALGGEDFDSHLVRWVLEDFKKESGLDLSNDRMAIQRVREACEKAKIELSSTVQTDINLPYITADASGPKHINTKLTRAKFETIVGDLVHRTISPCEKAIKDAGVTTKDIGDVILVGGMSRMPKVIETVKGVFGREPSKSVNPDEAVAMGAAIQGGVLAGSVTDILLLDVTPLSLGIETLGGVFTRLINRNTTIPTKKAQVFSTAADGQTQVSVRVFQGERELCRDNKLLGDFNLTGVPPAPKGVPQIQVEFDIDADGIVNVSAKDKATNRDQSMTIAASSGLSSDEIENMISQAEANAESDRARRETIEMANRADSVMTETEKAMDDFKEQLDKSEAEKLKEKIVSLRVEAMKAQSGDESVKPEELKAKIDELQSSSLKLFELVYKNRAAQNDQNNASNDANSSNSSNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KN63</accession>
    <name>A0A167KN63_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_150646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286515.1">
        <property type="nucleotide sequence ID" value="XM_018432527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KN63"/>
    <dbReference type="GeneID" id="28993433"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150646"/>
    <dbReference type="InParanoid" id="A0A167KN63"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="132" mass="14910" checksum="F156941B249F604F" modified="2016-07-06" version="1">MQETLFALQKGQEELQIGQDALKKDMNGQDNPEPTIVHNNLGGAIPRPVPNIKDITLVHIYRMLSHDLGVELDKKNKAILHTCTGLVCDELAIIPSVQALGQYPNWNFTRCHKNWASVAKVSQLWKNCKKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KTP2</accession>
    <name>A0A167KTP2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_149862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286896.1">
        <property type="nucleotide sequence ID" value="XM_018432358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KTP2"/>
    <dbReference type="GeneID" id="28993264"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149862"/>
    <dbReference type="InParanoid" id="A0A167KTP2"/>
    <dbReference type="OrthoDB" id="2276331at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="154" mass="18254" checksum="D4A3E396B1381C2C" modified="2016-07-06" version="1">MHKRKVAVQFSRLQARSTAVQQEHIDKVQELLDSHYVSAPEARWVNFSFKLHHAFPSHQRLVIYIKDFPTVSAFFFPYRDTENLNNMETSKCGLYVRYSKLAPLVELMSLHQNRPRTVHSLRDMVVLSLWCDDGEAWLFQYTRESDFLQESPDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KX31</accession>
    <name>A0A167KX31_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_150080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD69086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287126.1">
        <property type="nucleotide sequence ID" value="XM_018432395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KX31"/>
    <dbReference type="GeneID" id="28993301"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150080"/>
    <dbReference type="InParanoid" id="A0A167KX31"/>
    <dbReference type="OrthoDB" id="2290352at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="90" mass="9754" checksum="E67CFBBF3F945907" modified="2016-07-06" version="1">MTASTQRVAVPAYQQYAAPVYSPPNHTTINIQDPPNPYYGQPYPDNRATATTTNPSSSTTPPAYKPQGTSVAIPPPSYQDYNKDPRLQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LFP0</accession>
    <name>A0A167LFP0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Haloacid dehalogenase-like hydrolase domain-containing protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phospholysine phosphohistidine inorganic pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_115623</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288389.1">
        <property type="nucleotide sequence ID" value="XM_018428472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LFP0"/>
    <dbReference type="STRING" id="763407.A0A167LFP0"/>
    <dbReference type="GeneID" id="28989378"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_115623"/>
    <dbReference type="InParanoid" id="A0A167LFP0"/>
    <dbReference type="OrthoDB" id="426235at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000051">
        <property type="entry name" value="Phospholysine phosphohistidine inorganic pyrophosphate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006355">
        <property type="entry name" value="LHPP/HDHD2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01458">
        <property type="entry name" value="HAD-SF-IIA-hyp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD70349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="255" mass="27504" checksum="515ABDB06950CB6B" modified="2016-07-06" version="1">MIKGLLIDISGTIHIESKPIVGAVAAINHLRASKVPFRFATNTTQVSSRRLVDKLNKLGFNTTREEIFTSLSACRDVIESQALRPLLLLENEALEEFDGIDTSNPNAVVIGLAPSQMNYDQLNKAFRLVHQGAPFYAIHKGRYMAVADGELSLGPGGFVQAIEYATGVSATVIGKPSRDFFLAALRQIGMEDRPQEVAMVGDDVQSDLGGGAVQLGMQRCLVSTGKYRPGDEDGHKVMVFGSIVDVVNTVLSDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LL95</accession>
    <name>A0A167LL95_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_148607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288734.1">
        <property type="nucleotide sequence ID" value="XM_018432113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LL95"/>
    <dbReference type="GeneID" id="28993019"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148607"/>
    <dbReference type="InParanoid" id="A0A167LL95"/>
    <dbReference type="OrthoDB" id="2276242at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="22502" checksum="4F7A2C12C59252AB" modified="2016-07-06" version="1">MKFYPAVSASSAFPKDGMKDKDEVVDVMKTYAIENNFVLVTARSQIPILHLKCAKGGTYRGRRDGGENVKRSTETRRVGCPYLLRFSFRKKDQKYYLLRSLHEKEEYHNHPLSPKELSALHEGRMAKLTKEDITLTERLFKENAKTMKIQDLLNDERAPGNKLTTHDINNWRYSFDQRSDIRRSTTPDTSNNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LSQ1</accession>
    <name>A0A167LSQ1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_171077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD71016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289056.1">
        <property type="nucleotide sequence ID" value="XM_018436503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LSQ1"/>
    <dbReference type="STRING" id="763407.A0A167LSQ1"/>
    <dbReference type="GeneID" id="28997409"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171077"/>
    <dbReference type="InParanoid" id="A0A167LSQ1"/>
    <dbReference type="OrthoDB" id="2257229at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="616" mass="69300" checksum="7AEFC97E0F14CB4E" modified="2016-07-06" version="1">MRTQANDVHPKTTTAMVGIMVFIQRTTTTSILFAEVVRKPKRNRVKKYGNKAAINRIKTRCRKVWKNTDEVPKRTPNDAQWCLNNSNTLTVKNFVIEFGLTDRQYTVTRYQNILSAHFSRDRRENLLQDLDGWKKSLDAKIFWKEQARKQIVAETRVRCSAFVDSIIHEEGPQGSSINNDDSNNNVESSSSSSTNNRDRGTNINNSDDSNHNDRSISERNHSSSNSNINSNNESNSNSNNGNTGSCNNNSGSNTSNNNNSSSSESSNPGTLTPTKIHTPFIIKHVNVTDTFKQYQEYISSHYPTFTIEKDLQEIMAMANILFLAPDDHSDCKKKIFQLSNLDLMCTEMLQELKILDTQENKELFNDDEFIKVTRIINEVAEKTKTIRTAKLELLTLAASMEGGNKGSVVKGVANLLTKLSRVEILNMDKLGEVELQTTYYDALLSELIADQDKNEQTDIRSDAIVSMIMQHNFGHPVGFGEVKPGNSSTTKHSVSLDVLHLGIASKRAIDKWKLNSCFGFMINGFDLTFFITKKQHENCYTMLEIAQFTYASSLLNLHSFVSIMNLNKLTKVGRCFWNECHATNVTRDDEAGAMANDDAGVVPVSKLYALISRTCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M0L4</accession>
    <name>A0A167M0L4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GATA-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_102969</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289506.1">
        <property type="nucleotide sequence ID" value="XM_018427749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M0L4"/>
    <dbReference type="STRING" id="763407.A0A167M0L4"/>
    <dbReference type="GeneID" id="28988655"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_102969"/>
    <dbReference type="InParanoid" id="A0A167M0L4"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="39"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="91"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD71466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="147" mass="16585" checksum="C23B31D5418DD378" modified="2016-07-06" version="1" fragment="single">APSTPPHHHVFGFNESQKPIPPPRKGAASMSDDQAKPICTNCSATSTPLWRRSTDDELLCNACGLYQKLHNAPRPKTLKPHNARKEAREDEVSQLVCSNCSTTTTPLWRRDDEGAPLCNACGLYLKLHHERRPLSMKTDIIKKRQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M1F5</accession>
    <name>A0A167M1F5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_114288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285845.1">
        <property type="nucleotide sequence ID" value="XM_018428609.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289557.1">
        <property type="nucleotide sequence ID" value="XM_018428384.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297530.1">
        <property type="nucleotide sequence ID" value="XM_018427969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M1F5"/>
    <dbReference type="FunCoup" id="A0A167M1F5">
        <property type="interactions" value="230"/>
    </dbReference>
    <dbReference type="GeneID" id="28989290"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_106945"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_114288"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_117950"/>
    <dbReference type="InParanoid" id="A0A167M1F5"/>
    <dbReference type="OrthoDB" id="2439524at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD71517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="287" mass="33478" checksum="F36B3CC1DF62D042" modified="2016-07-06" version="1" fragment="single">SQGWMEKFGKRHYIKMNRIHGEAGSTDIESLQIDKAAIKEKIEAYSACDIYNFDETVLFYAAPPRTTISCQKFSGWKENKKRLTVGLLCNADGTDKWSDILMIGHARRPNCFNKNNKKQEAVDHGFSMYHYNSNDWMTRSIFHVFLHRFDRSMKAQNCKVLLILDNFSGHIVDYAPTNVELLFLPPNTTSHLQPLDGGIIWAFKAYFKRKQYAKAYQYIGMIQNDQQNKIGAIDKIFEIDQLWAMKWIREAWESVSAKTIENCWNATIFHFIEDKDSEGISKTIYWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M3C5</accession>
    <name>A0A167M3C5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Cytochrome c oxidase subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Cytochrome c oxidase polypeptide VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">COX5A</name>
        <name evidence="14" type="ORF">PHYBLDRAFT_125878</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289694.1">
        <property type="nucleotide sequence ID" value="XM_018429064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M3C5"/>
    <dbReference type="FunCoup" id="A0A167M3C5">
        <property type="interactions" value="203"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167M3C5"/>
    <dbReference type="GeneID" id="28989970"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_125878"/>
    <dbReference type="InParanoid" id="A0A167M3C5"/>
    <dbReference type="OrthoDB" id="5778907at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.40:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0349">Heme</keyword>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD71654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="138" mass="15578" checksum="A0A6D6E779A3C70A" modified="2016-07-06" version="1">MLRAAFTGVAARAVAVRSVTVSRPIAQVMGKRFYSGHEDESFEAYTERYVKFFDGVEDLFELQRGLNNAFAYDLVPAPSVVEAALKASRRVNDYATAVRIFEGLKEKVESEKQYEEYLKELAPLKQELGVLTKEELGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MMS6</accession>
    <name>A0A167MMS6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_145705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291346.1">
        <property type="nucleotide sequence ID" value="XM_018431517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MMS6"/>
    <dbReference type="GeneID" id="28992423"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145705"/>
    <dbReference type="InParanoid" id="A0A167MMS6"/>
    <dbReference type="OrthoDB" id="5588333at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="332" mass="37350" checksum="5CD09B96FBB96106" modified="2016-07-06" version="1">MSFSSFSLPTTPNSDEERHLFRQEIAELMYKRVIENEPKKSPGFTSPMFVIPKQNVGSSAGFSDISESLGRLPLYTGSRTITELPPVQAGGFDIPFQGISFRLICSPLVIYKDYLTNSRGSLQTGDQNPVAVKEPDLKIRCIQDLGHKYEEIGLSEEALNLLIEGSLTNTPTNRVYQRGQHLFITWALQHDVFPTEFFAQDLHQLFPPRVHLSPPLSQKSAFLLAMATFLRPSDFSKLRLFSATVNFTSGALTFDKHAAASLCPVRTFCALRDNPKAQFAHKRHFSSKSTNQAEQYRLLQFLLELEIRYPVPVGISDENGDEFSDVNEPTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MMY3</accession>
    <name>A0A167MMY3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glycoside hydrolase family 28 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_74883</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291364.1">
        <property type="nucleotide sequence ID" value="XM_018443037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MMY3"/>
    <dbReference type="STRING" id="763407.A0A167MMY3"/>
    <dbReference type="GeneID" id="29003943"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_74883"/>
    <dbReference type="InParanoid" id="A0A167MMY3"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046576">
        <property type="term" value="F:rhamnogalacturonan alpha-L-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronide lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF19">
        <property type="entry name" value="PECTIN LYASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007890425" evidence="12">
        <location>
            <begin position="23"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD73324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="380" mass="39365" checksum="DD0FAF7F5E46B191" modified="2016-07-06" version="1">MRFFGISSIASVLLLAVSTTQAATVCTVKTSSSGDDSVSINAAFAACKNGGTVVFPAGATFNMKSVVSATGLSNVKVEFGSTVNLPAYNTAFESAIAYFYLAGDKINFSGKGTFYGNGQAWYNAVNRNAPVVFKPKATNSYFGGFTIKQAPRAHFSINGCSNTIFENLTINTVSSKASYPAKNTDAFDVSGSTGITIRNSNIVNGDDCIAVNGGVSGLTVSGLTCTGSHGFSVGSLGKDGKTDVVSNLNFLNNKCINCQNGVRVKTWPGGKGSVTGVKFDNISLQNVDNPIIITTHYCDNEKSSSCNSASTSLSISGVTLNNIYGTVSSTAKEPIVNINCSTGSPCKSVTLTNINVTPASNTPKNICTNLSGSSSISYCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MY57</accession>
    <name>A0A167MY57_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase family 17 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_111830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292524.1">
        <property type="nucleotide sequence ID" value="XM_018428241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MY57"/>
    <dbReference type="STRING" id="763407.A0A167MY57"/>
    <dbReference type="GeneID" id="28989147"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_111830"/>
    <dbReference type="InParanoid" id="A0A167MY57"/>
    <dbReference type="OrthoDB" id="6474464at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003830">
        <property type="term" value="F:beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006813">
        <property type="entry name" value="Glyco_trans_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224:SF0">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN BETA-1,4-N-ACETYLGLUCOSAMINYL-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04724">
        <property type="entry name" value="Glyco_transf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="341" mass="39854" checksum="2A47F6673C32C6E9" modified="2016-07-06" version="1">MWLFFYHTGLITDLGYYTRPLWDSNPQSFNLIPHYYAEDVPMKDLCKLHGWTLKKKEDRPRVFDAIIFSVELDLLEIRIHELWDTVDIFIILESNATFTGSPKELVFKDNKERFAFGSSKIRHYVIDQFALPPGEGPFWNENEMRREMNNVFIKEDVQKGDLILMSDVDEIVRSKSLEILKSCAGVPELLHLQLRNYLYSFEFLFDDQSWRAHVETFIPGQTIYRHGQVTQDCLVDAGWHCSFCFRTIKEFQFKMQSYSHADRVRNPGLLEADRIQKVICDGGEIFDMPPEAYNYRELISKIGNIPKDLSAVGLPSFLLKNAQKFKFLMPGGCIRDDVDTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NI03</accession>
    <name>A0A167NI03_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_110337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293988.1">
        <property type="nucleotide sequence ID" value="XM_018428161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NI03"/>
    <dbReference type="FunCoup" id="A0A167NI03">
        <property type="interactions" value="230"/>
    </dbReference>
    <dbReference type="GeneID" id="28989067"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_110337"/>
    <dbReference type="InParanoid" id="A0A167NI03"/>
    <dbReference type="OrthoDB" id="2439524at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD75948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="305" mass="35418" checksum="70B340548B861F5D" modified="2016-07-06" version="1" fragment="single">KTKATIFAERIGVKDFNASQGWMEKFGKRHCIKMNRIHGEAGSTDIESLQIGKAAIKEKIETYSACDIYNFDETVLFYAAPPRTTISHQKFSGWKENKKRLTVGLLCNADGTDKWSDILMIGHARRPNCFNKNNKKQEAVDHGFSMYHYNSNAWMTRSIFHVFLHRFDRSMKAQNHKVLLILDNFSGHIVDYAPTNVELLFLPPNTTSHLQPLDGGIIWAFKAYFKRKQYAKAYQYIGMIQNDQQNKIGAIDKIFEIDQLWAMKWIREAWESVSAKTIENCWNATIFHFIEDKDSEGISKIIYWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NQ05</accession>
    <name>A0A167NQ05_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_143401</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294468.1">
        <property type="nucleotide sequence ID" value="XM_018430978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NQ05"/>
    <dbReference type="GeneID" id="28991884"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143401"/>
    <dbReference type="InParanoid" id="A0A167NQ05"/>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="61"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="470"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD76428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="501" mass="54835" checksum="B4B5224E6B10B2A1" modified="2016-07-06" version="1">MSTLEKNIEGDRTDSLHAEEISQSSQASYVPRQLEMDEVTLSESGATMVEESNVILKTYPQAWLALFILVLLRVSVSVFQYTYSVVPGLTAEYFNVGLTAINWLANVQGVVYVIMSLFTGWMFEHFGVKRTLMLSAFLSALGAGIRCIAGTFSSPSYALAMVGQVIGSSAAPLTLNIMTMFASTWFTEDRRATAGMFVASNYGGILGMFLLPNLATSVDRISLVAMVSALLCAGVFIPVIFMPSKPPTPPSIIQEQDKPSFFKGLRMLGSNYNFWVIFAVHSINVGLSISFGTLFTQILAPYGYTNIQAGQINAVAFFAGTLGCSVAGPVLDMTKQHLLFLRLIAPMVVITDIAFIFIIRKDAYAAILFVMGMNQFFLSFLVPVAIEIGSETSYPVADASTNSILWQGAQIFGIILVSAMDAMRDTEGTPKNNLFNALILQSVLAGVMMALAFIFRGRMKRSEAIALEKKRHVEHSQKKDGNRPENFQKETTKEESLAIFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NYN4</accession>
    <name>A0A167NYN4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type zinc finger transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_165386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294928.1">
        <property type="nucleotide sequence ID" value="XM_018435224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NYN4"/>
    <dbReference type="GeneID" id="28996130"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165386"/>
    <dbReference type="InParanoid" id="A0A167NYN4"/>
    <dbReference type="OrthoDB" id="2288491at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1206" mass="133417" checksum="D6FD9536F0798F9C" modified="2016-07-06" version="1">MTWGVVRMVGSQQNFGCLAVYEDSAGIQLKIQLGIELAIFANCSEISSFLLILGGSTKISSLIAGPTQRTLNTLANGEPGNLTPSAELPPLVDNFFSQVMRPFLKGTTNHSVVIDITALTVAQKPLFLSDLQTFFNGNKHLWAGTDQICCKYNRLLPYQYGHQDGRLAQLHADMTNNFSQFDAIVDCGYVTGSSGLYAGSGYAVLVLSPPNSTHSSVKLSHSLNWSYQPLDYSSDTGTLSSDFDHVSIFVTWAAMPPFCRYCHSDKHALINCDLLKKATMCCLCNAGGHIAKSCPCKNESSVTSQKRRKILVVQETPQPSTPSSSIVVPPLPSSSSTNVPTTTGRVKCIQGSLERSVTRSQASLVVPNALNNPNPIKEHKLPLPLQPNTNISPTHTASTISDYLSLASSLPFFSCKLNIGTINCCGLAKTADISSCNQFIRYLLTRSLDLLALQETHATSTLQDTFHSQFQAKTSFWSVHCGLISFSSDIILSNSFTSPCGCIISSTVSHLSMFLPIDKTNSPSCPLSALNFHPYFLSSPCHTVILRDFNYTYSPASPRVRQAPHNWLKYINEFFTDGITPPGQISNSTFHRGLSQSCIDYLFVSSDMASSIHFDHSRTTYVQPAWSDHFLLSAQLRLSPATHASSLVNAVGKGLWRSHPWLANNCLFCTRLTQSLHSCVHNFAPGLSHATKWEALKATTAKVARTFKDLLHRKHAGITKKLVTDPSLLPVLSPQLLVVEHQLSQLQQYHVENLALRSGLWWRELRESSPGYLKQSIASRASRKLIPPLWNPATSSICTSQEEMLETTTQFYSDLYSPDDVDQAAIDNLLNVLPTHLHIFSSTAESLVAPIMYNDLLDAFSRSPQKSSPGMDSLPYELIWLVVILRLKSTIMLSLCLIFLPLGYTRCSTVLNSLILSRLWHVLRVVSTPKSFFKSVQSIISQFINFRIFPWISFATACLPRSQGGLGLLNPELQQGALQLRWLGPILSTSSLQIWSRWPFSRSIILPCLLSFLQHHLQHHSNGYGHDPKDLDHWLLFLFPRRCPLILLTGQSSLSLLLHALEQLPHTFVGVIATTATCLEIPISYIITPTPPATLPQSIADLPISVAYTYDLHHFHCLRPKHRQECIVYPTLSHNVQALVSDPDTTMSSFFTHAFTAPSSGTFISPSPTAIFDHTFINVHPFLLSLGLVPRSSDPSRLKLTMKMYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P3E3</accession>
    <name>A0A167P3E3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_5370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295208.1">
        <property type="nucleotide sequence ID" value="XM_018440193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P3E3"/>
    <dbReference type="STRING" id="763407.A0A167P3E3"/>
    <dbReference type="GeneID" id="29001099"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_5370"/>
    <dbReference type="InParanoid" id="A0A167P3E3"/>
    <dbReference type="OrthoDB" id="60204at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044594">
        <property type="term" value="F:17-beta-hydroxysteroid dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078:SF57">
        <property type="entry name" value="DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078">
        <property type="entry name" value="PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peroxisomal multifunctional enzyme type 2-like N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="MaoC-like" evidence="1">
        <location>
            <begin position="156"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD77168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="255" mass="28484" checksum="BADD74A112A6AEC9" modified="2016-07-06" version="1" fragment="single">VACTKRDYLLYALSVGVPEEDLRWLYELDIDFGPLPTYPLCLLLKADDWDVNSFVERWSVGGPLPGVPPYDPNQILHGGQSLEVMVPFPEEGGRFKSLKKCTGVYDKGSGMVLEMTVDLFGEQDDVHYCRMITSMFVRGCGGWDGPKGPKLTLYTPPDRVPDAVDHFYTSRNQALLYRLSGDFNPLHADPSVALSVGFPRPILHGLCSYGKSSHAILKHFGNSDRLRFKSISARFAQPVLPGETVTIDMWQVEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PIM2</accession>
    <name>A0A167PIM2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_79153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD78014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296054.1">
        <property type="nucleotide sequence ID" value="XM_018443436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PIM2"/>
    <dbReference type="STRING" id="763407.A0A167PIM2"/>
    <dbReference type="GeneID" id="29004341"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_79153"/>
    <dbReference type="InParanoid" id="A0A167PIM2"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052567">
        <property type="entry name" value="OP_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40202">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40202:SF1">
        <property type="entry name" value="HD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="23120" checksum="476D92D07EC5EDA6" modified="2016-07-06" version="1">MDKSTFGSVIDAVFKVLIDGNADDETVLAALLHDIGQFVTSPDHKEMLFDAAALTDLDPAAAAAAAAESSASVSGSTTAINLNTPNKKKISVGVTGHERIGAEYLRSLGFSEKVAVLVEAHVPVKRYLTGKYPEYYDGLSGASKLSLKYQGGPYTAKEVALFEKDPLFELKVQVRQWDDAAKVVDLKVPGLEYYRPMAIRHLEEQASNRCSVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PSZ6</accession>
    <name>A0A167PSZ6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Basic-leucine zipper transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_185215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296524.1">
        <property type="nucleotide sequence ID" value="XM_018439048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PSZ6"/>
    <dbReference type="STRING" id="763407.A0A167PSZ6"/>
    <dbReference type="GeneID" id="28999954"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_185215"/>
    <dbReference type="InParanoid" id="A0A167PSZ6"/>
    <dbReference type="OrthoDB" id="2593073at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="4">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="157"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="321"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="373"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD78484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="551" mass="61370" checksum="81BCCD07B62FB63F" modified="2016-07-06" version="1">MYSMPLQARPSQSQSIDSLHNSSQDRRRSSQIHVESTPWINPMMQDQPSPESRNYIMPRHTESSLSNPHQAHPPLPRVYNTPPLPSSKMNRAVIPSKRAAQNRAAQKAFRQRREQYVKDLEKRSGEMEHWKEEMDQLRQENKRLRETVNNLERRLAEVAGESMPSPASNTQSTIMPGNSRTGQDSHDNELLTQQSTEIAQDNSDNEECGETPYSPGTMTTTTTIIIPSKSKRSSIASDEKSLGHIPVDNNSNSNSNSNRPDLKRSSTSGAGSFLPVPLRAPNQTTFMSPTERQSKEGQCTIGNPTLHDQELTKRRKIEPLNHNHHLSSPHTPHTPHTPHTPHTPHTPHTPPFSQTSPIPLRSYPITLSHPGYSSSSSASSSSASASSSAQQQQQKQQQQQQGDTQKTIYNTPGLDSSDTMRQGLGHPIALSHPQQMVQPGHDFWAFDPSQTLELDFDFDPFFEDELDPLSTGANGDDQPDFVTHANSGRVLDDLFAVLQTRQRPQIPIQPEKTLSSSDYTMETPARAFIPSIMGNDVYTSGLGESVGRRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PXD5</accession>
    <name>A0A167PXD5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_157624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296738.1">
        <property type="nucleotide sequence ID" value="XM_018433652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PXD5"/>
    <dbReference type="GeneID" id="28994558"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157624"/>
    <dbReference type="InParanoid" id="A0A167PXD5"/>
    <dbReference type="OrthoDB" id="25778at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="152" mass="16273" checksum="74325E0A23960EC3" modified="2016-07-06" version="1">MAELQDNLSKAMQTSFASSPTLKTPLGSSPSQIGKWLSSSSGAMGSSHGSSGSIARSPMQTSSLSFEDAYLISMGGAPGLDTAYETLGFTSQQQNNLENSSLIRFDEDEEESRSSSVRLEESAHNMGEVYSPDGDNEVAYPSDSVFGEFRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QCX9</accession>
    <name>A0A167QCX9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lon protease homolog, mitochondrial</fullName>
            <ecNumber evidence="11">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PIM1</name>
        <name evidence="17" type="ORF">PHYBLDRAFT_35101</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer or homoheptamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12 13">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="11"/>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297546.1">
        <property type="nucleotide sequence ID" value="XM_018440046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QCX9"/>
    <dbReference type="FunCoup" id="A0A167QCX9">
        <property type="interactions" value="332"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QCX9"/>
    <dbReference type="GeneID" id="29000952"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_35101"/>
    <dbReference type="InParanoid" id="A0A167QCX9"/>
    <dbReference type="OrthoDB" id="2411602at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070407">
        <property type="term" value="P:oxidation-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5270:FF:000001">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1480:FF:000003">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.40:FF:000010">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000015">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03120">
        <property type="entry name" value="lonm_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027503">
        <property type="entry name" value="Lonm_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718">
        <property type="entry name" value="LON PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718:SF2">
        <property type="entry name" value="LON PROTEASE HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11 12" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="16">
        <location>
            <begin position="63"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="15">
        <location>
            <begin position="761"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="682"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="853"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="896"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="469"/>
            <end position="476"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAD79506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="972" mass="106569" checksum="7E1AED7BF9F90D0E" modified="2016-07-06" version="1">MHLKERDPSDDPSGLPPSNGAAAGGQGENGDGWDDGKPPSGSPGATVENQLQKPTVPDVYPQVLALPITRRPLFPGFYKAVVIKDPHVTAAIKELLKRGQPYIGAFLLKDEKLDVDTITSIDQIHPVGVFAQITSVFPASAGKDGKEDGGLTAVLYPHRRIKMTELLPMMNKHSTATVKPSPTEQIAGVEHPAVEPAADTQYATAFLAEDYAVSVGNVDNLVDPPYSKKSPIVRAITSEIVSVFKEIASLNPLFRDQIASFSMSQSAGNVFEEPAKLADFAAAVSAGEQAELQDVLETLPVEDRLQKALVVLKKELMNAQLQNKISKEVETKIAKRQREYYLMEQMKGIKKELGLESDGKDKLVEGFKEKATKLAMPAGVKKVFDEEINKLAHLEPAASEFNVTRNYLDWLTQVPWGQRSRENYNIVHAKKVLDEDHYGLQDVKDRILEFIAVGKLTGSVEGKIICLSGPPGVGKTSIGKSIARALDREFYRFSVGGLTDVAEIKGHRRTYVGAMPGKVIQALKKVQTENPLVLIDEIDKIGRGHQGDPSSALLELLDPEQNSSFLDHYMDVPVDLSKVLFVCTANVLDTIPGPLLDRMEVIQLSGYIAEEKAAIASKYLAPAAKLSAGLEHVDVSLTEEAVDTLIKSYCRESGVRNLKKHIDKVFRKAAFKVVQDIGEDKFEQQKGDSPKVLEDDVRSNDPEKVEHAIEHGAEKEVGQEKTQEERKRLEVPDSVHVEVTAGNLKDYVGPPIFHSDRLYEQTPPGVIMGLAWTSMGGSSLYIESVLESSLSSKSSPHLSTTGQLGDVMKESTTIAYTFAKSLMASRFPKNKFFEKARLHLHCPAGAVPKDGPSAGITMATSFISLALNKPISHNIAMTGELTVTGKVLQIGGLKEKTIAAKRSNVTTIMFPKDNQADWEELPAHVKKGITGIPVDYYSDVFKVCFGDVEKEEVERLWQKELAEDEKKDEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QHZ6</accession>
    <name>A0A167QHZ6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyrimidine 5'-nucleotidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_154197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297761.1">
        <property type="nucleotide sequence ID" value="XM_018433305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QHZ6"/>
    <dbReference type="FunCoup" id="A0A167QHZ6">
        <property type="interactions" value="402"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QHZ6"/>
    <dbReference type="GeneID" id="28994211"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_154197"/>
    <dbReference type="InParanoid" id="A0A167QHZ6"/>
    <dbReference type="OrthoDB" id="1065058at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010237">
        <property type="entry name" value="Pyr-5-nucltdase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052791">
        <property type="entry name" value="SSM1_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01993">
        <property type="entry name" value="Pyr-5-nucltdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438:SF1">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD79721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21827" checksum="DBBBC13BC064A6BA" modified="2016-07-06" version="1">MSEQPVFFFDCDNCLYATRTLRERYFLDYGLSLRGLIKHHQIDAVEYDKQVDGTLPLEDVLKPDPELRDMIHGLKIRKWVFTNAYLPHAERCLKIMGLSDEFEGITYANYKDPDFDCKPELASFKRAMKEAGISDPSLCYLVDDSGANIDAAKALGWTTVHVADDPATSNHGDYQIDDIHSLHKVLPDLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QJN0</accession>
    <name>A0A167QJN0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_184926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297840.1">
        <property type="nucleotide sequence ID" value="XM_018439002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QJN0"/>
    <dbReference type="STRING" id="763407.A0A167QJN0"/>
    <dbReference type="GeneID" id="28999908"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_184926"/>
    <dbReference type="InParanoid" id="A0A167QJN0"/>
    <dbReference type="OrthoDB" id="10267139at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="entry name" value="CofD-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240:SF0">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="CofD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="610" mass="68597" checksum="E56591AC498CE2BC" modified="2016-07-06" version="1">MNRIQSYGVCMTLSIPEGWRYWCNQVSEHEHEHEHEYYYEYKYYAAHCILTSSTARNSQLYTAPAFQSISSDVCYVLGISDNGGSTSELLRVLGGPSIGDIRSRLIRLINVNQSDSVELRAIKDLLNYRLPSDGQEHAILNEWSLIVEGRHRLWNNISTEKKEAIRGFLVLFNFEILKRAYKHFNYRNGSIGNFFLTGARLFFGSLEAAIFLFSSITAIREPTHVVPVINTNHTAAIAARLENGEVLHGQCDISHPGENGAPNVRLMNPIDAFSRLALPGSPDPYEDDCTQNNGNLVFSKTTEERLPAVIDRVYYINEYGQEIYPIPNPKVIVQLATSTTLVYSIGSLYTSILPCLILRGVGNAIARSPTLRHKVLLLNGHNDRETGDFCAIDFIQKITEALNESQLIDARRQYYDRNQPYNFGTNTSPKEAGGAGSLEFEYLGHQANSGQHEGYPLANSSVPRPQKVTDQNTDLFSVPPFPSDLIPYSPPRTFITHLIYLSNSKICVDVEEIEKLGIKCISIEPEAGLEPGYSSAKLEILLPKCRPIRNQISLSQEQNTASKFFDYNIYSSYAKDYKGLLSLKCDAILFDILLFIGLLTCIMSLTFFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QU62</accession>
    <name>A0A167QU62_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_9972</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298318.1">
        <property type="nucleotide sequence ID" value="XM_018444105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QU62"/>
    <dbReference type="STRING" id="763407.A0A167QU62"/>
    <dbReference type="GeneID" id="29005010"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_9972"/>
    <dbReference type="InParanoid" id="A0A167QU62"/>
    <dbReference type="OrthoDB" id="2248925at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD80278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="50" mass="6055" checksum="BBBBC6C0CF97D986" modified="2016-07-06" version="1" fragment="single">YEVEDIRDHRGTAGQREYLVKWAGYGERTNTWQKAEDFTDSTIVQKYWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QVX3</accession>
    <name>A0A167QVX3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_137916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298398.1">
        <property type="nucleotide sequence ID" value="XM_018429900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QVX3"/>
    <dbReference type="GeneID" id="28990806"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_137916"/>
    <dbReference type="InParanoid" id="A0A167QVX3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="98" mass="11332" checksum="0FEEA763D484944D" modified="2016-07-06" version="1">MPLEHDVSYTDTFGTRHFASRARRFLHSHVWDTTFCLSGMTDQIKLLDAGQQVTFYEAAILEQKVHRPLQSSLQIAFRNLYSTFRVIATPIKTKPFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QWL0</accession>
    <name>A0A167QWL0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_61444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298434.1">
        <property type="nucleotide sequence ID" value="XM_018440807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QWL0"/>
    <dbReference type="STRING" id="763407.A0A167QWL0"/>
    <dbReference type="GeneID" id="29001713"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61444"/>
    <dbReference type="InParanoid" id="A0A167QWL0"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="294" mass="33921" checksum="B82B980DAAFBF21C" modified="2016-07-06" version="1">MTVTDTPDGCYATSTLLTRWVDTVNQQSPIHLALISLPITRPCVFRLRSLEDVYAKSALFRFLIRKGLPPVPLFLSTTAAAAWAMKRSYDHSRFLVVQIVGTLYPLWKCWQLVKQTDHQEPDTYKAWLTYWMIYGVFQVLDHWSIQMHHHCPNYTLYRLAILYWAQSSKAYGASLIHRHVIQKPEDEDDDVPALSPSSRSHVVNELSYRILDGYQPNLGRKTSVSSGSHDSQASFRINEPAYTVDHCPPQEGELIVRGENRHSEGRWKDKLNGRHKNFLLLFDKEDLCRFESTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167RAH8</accession>
    <name>A0A167RAH8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_161850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299267.1">
        <property type="nucleotide sequence ID" value="XM_018434498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167RAH8"/>
    <dbReference type="STRING" id="763407.A0A167RAH8"/>
    <dbReference type="GeneID" id="28995404"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161850"/>
    <dbReference type="InParanoid" id="A0A167RAH8"/>
    <dbReference type="OrthoDB" id="2207231at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD81227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="259" mass="28769" checksum="8188DBFDC0EDB0CC" modified="2016-07-06" version="1">MPNNYALAVKIGTLRLICLYLPPSMPTHEALDILSAITLTDDTIILTGDYASNPRGIALEQWLEERSLTVLNGVLSLCTPTYISFRNEVEISSIIDLFITNTNFANPSLHIATELSLGSDHQLLSLSFTYDLQHLLPAPPPMCQTWNLSRLYEDDTLFRICQLYVHPLMLLLTLPMHSFMTLLVAQLVLAPLAPHIGNRFGPLNCKLQLTIKMVVTSNDVELVALTRSIGGAGTSMHTRSFVSKFRQQIICLGMLFAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167RAU0</accession>
    <name>A0A167RAU0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_161867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299287.1">
        <property type="nucleotide sequence ID" value="XM_018434506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167RAU0"/>
    <dbReference type="GeneID" id="28995412"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161867"/>
    <dbReference type="InParanoid" id="A0A167RAU0"/>
    <dbReference type="OrthoDB" id="2206543at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="34360" checksum="4540E2C01B1B29B0" modified="2016-07-06" version="1">MRALQSLGVNHTGLSRLLSIRLYRQFIRPQFEYGLAISCFNIKQVAVLEKAQNTCLRMIFGGHSTSSTSVFRHLGNLPSMRERILTLGFKFVYRAFWLPDEALFTLLRPVLTNPAHQWFKLLANPIWLSLSNRQNADSKACKHAIRSFLNQGLSLQRSQQILLSACRPSLGVDPILWLPMTNYERSRFIRWRMGWLPGRPQPCSCGLHTTSRHHVIECTGAAIRLHLYSTVQPNPIDYVLNMLPLKTPKNNKNNAFWIFTWPILCRIMLDIEQICLPGVDLADHAATDRGQLFLNWLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167RBR1</accession>
    <name>A0A167RBR1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_161914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299339.1">
        <property type="nucleotide sequence ID" value="XM_018434529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167RBR1"/>
    <dbReference type="GeneID" id="28995435"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161914"/>
    <dbReference type="InParanoid" id="A0A167RBR1"/>
    <dbReference type="OrthoDB" id="10678527at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD81299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="310" mass="36042" checksum="8875C4A096B39FCD" modified="2016-07-06" version="1">MYGFSQKCPLGFVIKNFNQISCYICNIRCKFCCVDTKRLYHVHMSYCRQIEVDLAEIKQALRKLQRQFSNQFAPAVSAEDLTTMQQSIIEQSSLERIAESVKRAQLTEYPDQLGKRVINTGVEFKGKNEAQKYNLLLQILHEQDWKARCKEVSQGQPLPPLVPLSDHDLTVKRLHLKTLGRMVKHDIIDKDYPAASKEWKNIPEKNREYYMMHLERLAKNGRLHIHQYKRMWCARSLLWESFKSDNQTHKRRIAEKNKTQQDIGDSSLSSPDMSETSDVEAPIMADVLSPLLSRCSDYGSDRIDYLTPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167RC96</accession>
    <name>A0A167RC96_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Lysosomal dipeptide transporter MFSD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Major facilitator superfamily domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PHYBLDRAFT_79623</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79415"/>
            <dbReference type="ChEBI" id="CHEBI:192470"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:79367"/>
            <dbReference type="ChEBI" id="CHEBI:229968"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)</text>
            <dbReference type="Rhea" id="RHEA:79375"/>
            <dbReference type="ChEBI" id="CHEBI:229967"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79383"/>
            <dbReference type="ChEBI" id="CHEBI:229966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79371"/>
            <dbReference type="ChEBI" id="CHEBI:84315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arginyl-glycine(out) = L-arginyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79391"/>
            <dbReference type="ChEBI" id="CHEBI:229955"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79411"/>
            <dbReference type="ChEBI" id="CHEBI:229953"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79379"/>
            <dbReference type="ChEBI" id="CHEBI:229964"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-histidyl-glycine(out) = L-histidyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79395"/>
            <dbReference type="ChEBI" id="CHEBI:229957"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)</text>
            <dbReference type="Rhea" id="RHEA:79399"/>
            <dbReference type="ChEBI" id="CHEBI:229954"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79387"/>
            <dbReference type="ChEBI" id="CHEBI:229965"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79403"/>
            <dbReference type="ChEBI" id="CHEBI:229956"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-glycine(out) = L-lysyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79407"/>
            <dbReference type="ChEBI" id="CHEBI:191202"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299368.1">
        <property type="nucleotide sequence ID" value="XM_018443483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167RC96"/>
    <dbReference type="STRING" id="763407.A0A167RC96"/>
    <dbReference type="GeneID" id="29004388"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_79623"/>
    <dbReference type="InParanoid" id="A0A167RC96"/>
    <dbReference type="OrthoDB" id="424834at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052187">
        <property type="entry name" value="MFSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
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        <property type="entry name" value="MFS general substrate transporter"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="20">
        <location>
            <begin position="59"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044881"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044884"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044891"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044898"/>
        </source>
    </evidence>
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        <source>
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        </source>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044985"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00045709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OAD81328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="529" mass="57797" checksum="B95EC24A0B3BB20E" modified="2016-07-06" version="1">MADNSHNHDLAEKTQTVPVEKSELYMNEELEKNEQEVAPISNGGDTAFANASWQYKTIALVTALLFPLGSHFSASALSAMKAPIKANLHIDNTRYGVLASAVSIINTIFPIAGGVFIDMFGSVWGTLAVNCLIIIGSLLTAVAAKIESFALMVVGRVVFGIGSGLIVTMQESLLSKWFRTEHLSIAIGLQLSISRLSTFLGTLVANPIAEKTGDWVWAFWLSFILCGFSILMNVIYALTVMKLRGNVVISKEEVARLKNKKTFKWRSVFKFPTIYWHIILIEFIFAAVWSSFQTISTELVIVHFNTTSVLAGYTASASQSIPIVATAVLGVFMDYFGHRITVLLISAIFLILSSGLLGWTYVDAIVGMIFYSISLAFGPIAMITSIGMILPSDYIGTGLGIYKSSNNVGTTILDIVVGVIQDNTHNQAYTGVMTLFIVLGGIGFVLIFGLIITQRFYLRNLLQTTRANRTAIMKEVNDKELFYTQQGLDAYTGVNPAIQNYIYVGCFIVCLLVAWVLFFVYAATGGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N2P5</accession>
    <name>A0A162N2P5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_176284</name>
        <name evidence="2" type="ORF">PHYBLDRAFT_72586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">NRRL 1555</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OAD65231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OAD65234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018437720.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018442679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N2P5"/>
    <dbReference type="GeneID" id="28998626"/>
    <dbReference type="GeneID" id="29003585"/>
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    <dbReference type="OrthoDB" id="2210734at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="216" mass="24445" checksum="4690A15609EF7CB8" modified="2016-07-06" version="1">MFDSFTAYIAISFIVNKDSSSLIDVGGTKLLHSQIWHNERFPGIVIFLEVIPHGFDSHCTEFTSAVQIGIHFPDHNNTICGAIFLTVDNQVQKLTLLRLPAVDKQEHIDDIREILAIYGRILDVGICQKPKYCHGDGYDCSNFNTHPTFQRGFWLCYENGHAKPNWFHGTVRHIHPQMYHKSQSPGSMDVDFVSHNAFNPNPIFVAVSVDTNSTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N7N5</accession>
    <name>A0A162N7N5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441002">
        <property type="protein sequence ID" value="OAD66564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284604.1">
        <property type="nucleotide sequence ID" value="XM_018439638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N7N5"/>
    <dbReference type="GeneID" id="29000544"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_189293"/>
    <dbReference type="InParanoid" id="A0A162N7N5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="184" mass="21412" checksum="2FA4976716E792A8" modified="2016-07-06" version="1">MMISCNICFSTIIFYDLVLMFLVLLTRVLVVVFQFLKAFFLYYIWLLECIYCLTSVGVTIMTSSHKSALGLPTKLAPYRSDTVYPELQVIVIKDEVYKNKLIYCCAGVSPNEVLTSKLKKFLRGRIEDLRLGTKIRENLCRFCLLRKILYQSLTSPNEVLTSKVNVFMSYNYAYNNPLMYPILW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NB00</accession>
    <name>A0A162NB00_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_69353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285524.1">
        <property type="nucleotide sequence ID" value="XM_018442082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NB00"/>
    <dbReference type="GeneID" id="29002988"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_69353"/>
    <dbReference type="InParanoid" id="A0A162NB00"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="186" mass="21025" checksum="DAAB646BCF38081A" modified="2016-07-06" version="1">MSAEQAYTGTGTGTGTHTHSPLLSDLLSILKLDTFRNRISAILTIGIKLQMIMCVLPSRIYKTNHTFMSQTNNFNIVLLAHPISFWSVLRLAEQIIRGFYTAGQCFKVNLAKNNEMMKEVVQCILMQLMTVMNILKGLKKLAQLGIYTNLLYFLFFFSYSKSGQKFRVFMVARGDIHCVKRLGALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NBG8</accession>
    <name>A0A162NBG8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_173937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285644.1">
        <property type="nucleotide sequence ID" value="XM_018437142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NBG8"/>
    <dbReference type="GeneID" id="28998048"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_173937"/>
    <dbReference type="InParanoid" id="A0A162NBG8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="355" mass="40911" checksum="2C197487E2DDA4D6" modified="2016-07-06" version="1">MSVYQLFSGINYIDYSKCRTMYYLPLITPIYIIKSYEPMRHSRTCLVLEYRSYKNVKNHFNYKKGEIMAPRTNINQNARTNRSTSRPLINAVNTGRIESSNPMIAPRPENMSIPVSEFNDVVSLLATLNDKMTAVSSDVSELKVQCQVGAQLTGMQAVLDSDMDPQDIISSSRHPKISSIIQGRLRDINLKTDDLELIRENDDKPTWDVNVGLSDEFNKNLASDLMLYIRRQPVAAMVPPKELCGIIVNSYYNRLAASKLTEEDRQTNTTSNRRGNRKTALNKRRKRTYTKHKDAVTEKFNRDYNGVFYRDAMSGDETETDTSVVASRPDWRSDEVMFYIKWFFCCLIPDVYIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NBP1</accession>
    <name>A0A162NBP1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 13">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="13">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHYBLDRAFT_26125</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17 13">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11 12">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="13"/>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285754.1">
        <property type="nucleotide sequence ID" value="XM_018439883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NBP1"/>
    <dbReference type="STRING" id="763407.A0A162NBP1"/>
    <dbReference type="GeneID" id="29000789"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_26125"/>
    <dbReference type="InParanoid" id="A0A162NBP1"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46161">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46161:SF3">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE DDB_G0292928-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="14">
        <location>
            <begin position="10"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="11">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAD67714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="143" mass="16233" checksum="60DAAAA4F80A90AA" modified="2016-07-06" version="1">MTAPTSLCQPQLTLGVIKPDGMAHLDLILDAIDRHGFRIVEQHTTTFAAEVIDEWYSDKLGRDFYPSLRRYLTRGECRVLVLERVDAIKALRRIIGPTDPQKARRVDPQSIRAQIGGSIQENAIHASDSEEAFERERRVLLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NBV6</accession>
    <name>A0A162NBV6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_136608</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285844.1">
        <property type="nucleotide sequence ID" value="XM_018429799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NBV6"/>
    <dbReference type="FunCoup" id="A0A162NBV6">
        <property type="interactions" value="487"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NBV6"/>
    <dbReference type="GeneID" id="28990705"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_136608"/>
    <dbReference type="InParanoid" id="A0A162NBV6"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1060.10:FF:000006">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774:SF1">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="7">
        <location>
            <begin position="30"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD67804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="191" mass="21829" checksum="2291059D59902347" modified="2016-07-06" version="1">MSLLSRTFQLATHLVPSQRTFSTTLGMTEKATFAAGCFWGVEHMYNKYFKKDGITTKVGYIGGKVDNPTYKQVCSGATDHAEALEITFDPKRVEYAKLVEFFYNMHDPTTLNAQGPDRGTQYRSAIFYHSPEQKEIAEKVTAEVQEKHYKGKKIVTEIVPAGVFYDAETYHQLYLEKNPSGYECPSHFLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NKK9</accession>
    <name>A0A162NKK9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_171283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288574.1">
        <property type="nucleotide sequence ID" value="XM_018436558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NKK9"/>
    <dbReference type="GeneID" id="28997464"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171283"/>
    <dbReference type="InParanoid" id="A0A162NKK9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="688" mass="78284" checksum="A569E01BE7A5D81C" modified="2016-07-06" version="1">MFPSIQMHNTDCHCIRCNNNDQGVSRVSRRTAQRHNKRARFEAEKRSMEVDTEIIPTYQSDSVEAMDGQANSPISDAVSTFDNDVFVGNDYNGDESDTTDDNDSDDNGEEDTAEIYVEEFNNEDPFAASGMPENPVHRFIATFTVLFASRYVVNKGSVVLIEFINELLKIYGQDFQLPESLAGLHKMTGFLSITKGIKRFVSCPNCHCIYEENMSVPPHCVFTNVGARSPCGLRGTIIDPMHNLFLGTPKRMMDRWVDKKTIGAEEFAAMEKIAETMVLPRDYTKLTSKIGKGFPYMKADDWKSWVLVYSPVLLHGVLPFEMYNNWMNFVRACRYLIKPSITFDEVNSAHDYLEMFCKKATELYTPTILTCNMHLHLHLCETIRDFGPVYGYWLFGFERYNGLLKHIKTNGKDSFEATYMRSFVQNAFKGDYANAVLKSSSHVPFFNILSKLSPKFTPTTTVITLSSHPFRLQSFLLASSNPHLPPKGNEPLPPSTFPLQLKKSSLMDETDYAHLLQHYKTSYDLPDLVSYQYATLTNSFVDNEITKLKFIDLLGQQYRGKNGSASCGSLVHVMFVGSDGRNTLAYAGQVQYLFTHSFTHPSNSNLHLTRMVHDHRHVFAYIKWFNTSSDRSREDDGLEFCLPTFSPDSRHCIVSVHRIFLEIATARITTSRNVSKMLVIALPKKLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PFD3</accession>
    <name>A0A162PFD3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_176356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441030">
        <property type="protein sequence ID" value="OAD65166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283206.1">
        <property type="nucleotide sequence ID" value="XM_018437749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PFD3"/>
    <dbReference type="GeneID" id="28998655"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176356"/>
    <dbReference type="InParanoid" id="A0A162PFD3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="135" mass="15487" checksum="23062AEBA81A6AA0" modified="2016-07-06" version="1">MLLGKSESIQKELLGSDIFFKRQKICRKCQYKKTVAYGHGESVSEKNCVSSLFVVTFPTKFLTLKSAVFQFNSRGREILRLESTSLMASQGRSRREGRKFCTKSPIITIDPKKKAGEKEPVEDQPVEEYDWELLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PK33</accession>
    <name>A0A162PK33_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_182792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287636.1">
        <property type="nucleotide sequence ID" value="XM_018438675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PK33"/>
    <dbReference type="GeneID" id="28999581"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_182792"/>
    <dbReference type="InParanoid" id="A0A162PK33"/>
    <dbReference type="OrthoDB" id="2270519at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="237" mass="27354" checksum="8B05C762DD219917" modified="2016-07-06" version="1">MLYTTKFDEKSLLSFIKWCNTKKVLYMNQEQERKVLKDQNGSKVRYRVLWTLKDEYLNGITLSITEHLPKYQAYIKNLKKNNFTVIGYARKSPGQEHQEVRVGLVQKMVNKLYDTLLVDKVFVTTSSRANDTITSRDTNGKNAQLTLLNQVHGNTQDLLEYICTSKNDCLVAIDFAGLSTNTSDLYDFIVAHGSIKKIIIDLSSSTGFMKYYNRDDIIDNPSILKDFDCRKPCYKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PN70</accession>
    <name>A0A162PN70_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Threonyl/alanyl tRNA synthetase SAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_133339</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292477.1">
        <property type="nucleotide sequence ID" value="XM_018429565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PN70"/>
    <dbReference type="STRING" id="763407.A0A162PN70"/>
    <dbReference type="GeneID" id="28990471"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_133339"/>
    <dbReference type="InParanoid" id="A0A162PN70"/>
    <dbReference type="OrthoDB" id="288942at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002196">
        <property type="term" value="F:Ser-tRNA(Ala) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043039">
        <property type="term" value="P:tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051335">
        <property type="entry name" value="Alanyl-tRNA_Editing_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462:SF1">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN AARSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Threonyl/alanyl tRNA synthetase SAD" evidence="5">
        <location>
            <begin position="196"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD74437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="411" mass="45776" checksum="C17F6562659BFB67" modified="2016-07-06" version="1">MSSNQIPVGDLHCQKDTYSKVCITKCISCSEKPNKKGFYEVKLHDTVIFPEGGGQPSDTGMIDNIKVYEVQRKKLEHIHFTKEPVPVNKEVEVTLDWNRRWDHVQQHSGQHLLSAVLEKEPYNMETLSWNLGPAKCYVELSTKNTKTLGAEQLATLESRVNDLILEELPMECHVEANTGDGRPDSLPADYVGGGSIRTITIEGLDTNPCCGTHVRHLGHLQVLKLLHVESARGGNIKLFFLFGQRVLDTLDVAYKTSRQVTSILSVPQEQFVENITKLQQQTRASQKQIKRLMTELAGHTATEVKLQLKSQPYGFVYRPDGDMDFLVDIASALKDTDDIKDKVVVLAAGEKQTGGQMLITGGSEEIVQKTAKALLAAFPDLKGGGKARWQGKAKSWKTIDTLDTHLKTLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PP47</accession>
    <name>A0A162PP47_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_159297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289636.1">
        <property type="nucleotide sequence ID" value="XM_018433963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PP47"/>
    <dbReference type="GeneID" id="28994869"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159297"/>
    <dbReference type="InParanoid" id="A0A162PP47"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="102" mass="11283" checksum="32CC1A48179F0AF8" modified="2016-07-06" version="1">MPLATFGSGCFTTRSHVNPCCITVFPPHFPPLIVRCVERKLTLKTIFSTHAHSSFLSGTHSGSRISAFPPNPLTFTMRYTSFPSLPPLIPLHILPQSLALFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PS31</accession>
    <name>A0A162PS31_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_65570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290426.1">
        <property type="nucleotide sequence ID" value="XM_018441483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PS31"/>
    <dbReference type="STRING" id="763407.A0A162PS31"/>
    <dbReference type="GeneID" id="29002389"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65570"/>
    <dbReference type="InParanoid" id="A0A162PS31"/>
    <dbReference type="OrthoDB" id="2283865at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="244" mass="28589" checksum="D16960A46996D957" modified="2016-07-06" version="1">MKSKNEQMFVHPRLFGLFPKPGLGWRVIKIDSKNIAGVFPEASLKREVNEPLFRYTQKRFHNGFHFANLEHLHNLPIKNGKMFLNGLYLDGYTCLVLFCRKFQPALPVEKVSLELKDFSDEEVNEHFRPCAGYIGRKYAFVSYHGSNDLRSLSSKEYYIMGSTIRRQGKEQEHKKKLGVEKIETNTPTPKTTSCQRYISHIDYMFRHTGVLFNFDGFRIVAIKWRNYIGPQKNIEYSVDILLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PS75</accession>
    <name>A0A162PS75_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_169545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290456.1">
        <property type="nucleotide sequence ID" value="XM_018436099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PS75"/>
    <dbReference type="GeneID" id="28997005"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169545"/>
    <dbReference type="InParanoid" id="A0A162PS75"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="322" mass="36170" checksum="FDB22B49B8DB4E26" modified="2016-07-06" version="1">MPTPNCRLAPSLASTDVQLLQALNAMKEEMKAMKDKITLMDARIGVVITGNATAINGIDALSALPASAHVPTSVASTSAALPITESSDTNAVFASIKIQKTLANLGYIHGYMWNPKLKSRDQAEIQANAIKPKWAVDVRFDCSPNRELVKQLLYYLEKKFAGTDMRTRDLRKCIYTNFCSRRCQQRELLETRRALNTNSRRSGRETDNYTRRHLAYDAYKADIDLKMGRNCSGLIQKSVMSEGESDDDMSPSQPRNEIRVARPSWRSDELNKFITEIDSFVVKQLGANSRQLLKRVYDRTVESTVPTDLDPALPQWALKYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PY84</accession>
    <name>A0A162PY84_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_166589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293376.1">
        <property type="nucleotide sequence ID" value="XM_018435438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PY84"/>
    <dbReference type="GeneID" id="28996344"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166589"/>
    <dbReference type="InParanoid" id="A0A162PY84"/>
    <dbReference type="OrthoDB" id="2269854at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="442" mass="50788" checksum="6FB6A5A211A50602" modified="2016-07-06" version="1">MPIKYEENNISFKNYKHIWQNRIFAVAEKYNILLIKKTQSWEEIEDAVCKKSKQSTSIESSSQSTASHDSSSSNLSYKLTKHDKDYIKEIYEGLNSQKMWTLSTGTVVEMKMAELAKECVYEHPCHSLILDTDDETWGGYFTQEELEEIQAHKAKPLKPVPSELFEYLNNITQDENIETMHERIARTYYSPKKNSSCYWAQKSLLDGLDLHMSGFFKSFIEHSERDYLSRVWRLVLTVFDSSVITAREEICSKASSFESNRGQQIASVTNIGRKKSAKRPDHIFRYGSFELGISEAAKVSDENGDKDIKDSRIKAPKLMKDLMQKILENKPGLINTLRIPSIIMSGLDIKMFILDIPEGYVSRITRTETYSYPSEYMSFVSEIRSCLELAWLARGIMEETVEALTSVTRTTIVIKRKKDFSLPPNFKSTKKKITGLLTLPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q6I2</accession>
    <name>A0A162Q6I2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_120456</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298566.1">
        <property type="nucleotide sequence ID" value="XM_018428740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q6I2"/>
    <dbReference type="STRING" id="763407.A0A162Q6I2"/>
    <dbReference type="GeneID" id="28989646"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_120456"/>
    <dbReference type="InParanoid" id="A0A162Q6I2"/>
    <dbReference type="OrthoDB" id="340346at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000062">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit A alpha isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="31"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="70"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="185"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="224"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="263"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="4">
        <location>
            <begin position="296"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="302"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="341"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="380"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="419"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="458"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="536"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD80526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="609" mass="67826" checksum="B41F169CCD60724F" modified="2016-07-06" version="1">MEVDTHAVTPTEYMDEDPVNMTQPAQDELYSVAVLIDELKHEDIQLRLNAMKKLPIIADALGQERTREELIPFLRESIDDDDEVLLALAEELGKLTDAVGGPEYAHYLLVPLESIAAVEESTVRDRAVASLCTLADVLPQRQLNEYFVPLLKRLSMGEWFTSRTSATGLYAAVYRKSSKELQAELTSMFSQLVQDDSPMVRRAAAKALAQLAGQVAPEDIFETSVNWFHKLAQDDQDSVRLLTVESLAALAKLLTPEQNLEHLLPSFKSLADDKSWRVRYMVASKYVEISQAFGETIVREHFTAAFINLLRDPEGEVRTAAAGQVPGYAKLVEKSVILENLLPCVRDLVTDENQHARAALAKEISGLAPIVGQEATMEFLLPTFLQQLTDEFPDVRLNVISNLEVINQAIGIDRLSQALLPAIVELSEDKQWRIRLAIIEYIPLLAKQFGAKFFEEKLLSLCMSWLRDSVYSIREAATVNLKRLTEVFGGEWAKKAIIPQVLKMATELKYLYRMIMVSALTTMAEALPYEIINDSVLPTIMKLADDPIPNIRFSVAKSLEALVPLLKQTGDKAGLIPSTIKPALVKLSLDGDGDVKFFATRALESGTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q6L1</accession>
    <name>A0A162Q6L1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_61609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298596.1">
        <property type="nucleotide sequence ID" value="XM_018440829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q6L1"/>
    <dbReference type="FunCoup" id="A0A162Q6L1">
        <property type="interactions" value="470"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162Q6L1"/>
    <dbReference type="GeneID" id="29001735"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61609"/>
    <dbReference type="InParanoid" id="A0A162Q6L1"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055555">
        <property type="entry name" value="PA-PLA1_DUF7131"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057826">
        <property type="entry name" value="WWE_C20G8.02"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF10">
        <property type="entry name" value="LD21067P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23465">
        <property type="entry name" value="DUF7131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23463">
        <property type="entry name" value="WWE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="2">
        <location>
            <begin position="540"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD80556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="808" mass="90239" checksum="B9DFA31943620449" modified="2016-07-06" version="1">MLEPEPYPRGHSPQRRTLRPHSLIPDLDVPPLIPHWFHAIDNALVDPVSMRTAKEAAMSRRQPKSPSAPKSKSTAWVPFSKRDSIALEKAFQNNDVRAKVPVNEDYLFEVDVSERTIYPVYWEGPTFEVRRATWFMQADGSKWVPCEETLAEQIELGYYKHKPYVVDPVDEGNYQGNTLAPKTLTKKPSFSAPKIDEASNSATEEGKLEATLAKQLSERQWNLLGPYLGQYIVYTGPSAAWLLSNSTSSKFAKSIITRLTNKQNLGGTRVLRGYPEIEKQQKNKAPVAPVAPKADNDRKNSDTKQKEDGDSKEGPEEDTGLSQEAEEYVSMESEEEVRKIDHIVFVIHGIGQKMSEKTGHSFVNDVSTLRKTMRSVYPTVMASTKTPNHPNGIQVLPVLWRQDIRFGIASDNEGGEADLGMLEPDDGCPTLDELTLDGVPNIRNIVSDVLMDIPLYMTPRYREQMTQTIAKEINRVYKLFVQRNPDFLDGGRVSIYGHSLGSLLAFDMLTMQPMSVQETNSASLKPTESAAVVDKKKVQLKFPVQNFFAVGSPLAVILLLRGFKIGSRKSLSNTQNYSSYADISSIPSSHISHCYPAIDNLYNIFHKSDPVAYRLEPLIARHYSSKLKPEPIPYLKGGLRSMIDAGLNVGSGIANRAGAMYESLKMGITTNLFMRGLGLSRQQIYQDRHPSSDNEDELSTRENPTKSPPNGLYRTRSNSDPACATSMALKSKIRKPPPSPLPSSASPYSVGARKLKMLNSSGRVDYCLQEGLLENPYINAFSAHLQYWQDLDVAAFMVREIYRNQLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162QAH8</accession>
    <name>A0A162QAH8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_138984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299476.1">
        <property type="nucleotide sequence ID" value="XM_018430123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162QAH8"/>
    <dbReference type="STRING" id="763407.A0A162QAH8"/>
    <dbReference type="GeneID" id="28991029"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138984"/>
    <dbReference type="InParanoid" id="A0A162QAH8"/>
    <dbReference type="OrthoDB" id="2262863at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF34">
        <property type="entry name" value="NOTOCHORD-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="464" mass="52710" checksum="3CD8814A7D116BE4" modified="2016-07-06" version="1">MCEAAKDRLSIENIRFIATVPKKNGAKGVSILPILVRDLKALEKGVLMFCEKDKQCVLVIAPVLWIGADTPCHSEICGLSGPTSLYPCRKCYVCIHRLKDSLPDKEYCTDPHKRRTRKHYVLANSMSDRTTIIPDAPTDGCNLSVEDLSFQDRSTGSLLELDAFDPSSGTPVEVIHTILLGIGKYMVIHLMNGILKSKKDIIQRLKTCLDGYKCSTGLSRKFTRNINHSGSYVGRDFKVLLQILPVILVTDFSNEPILDRIKPCFVELGRLCSLVFVREVTSGFDDYLVEVDLSVRRLLGQLHNYDTFKRAEVKENNKTAKIKKKYTAFCTKRKIHNLTHLKYDIRRFGTALQFETEKGEQFNKHIREHLFHTNHKNTSRDVCLKLAKQAALQYVMDGGSWLNENGQRERPGCGIAAFLQGKSEKKFRFSFFGGSRDFTSNNDTGDRDEERIKNNSFGAFIFYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TFR7</accession>
    <name>A0A162TFR7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_152051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441000">
        <property type="protein sequence ID" value="OAD66783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284823.1">
        <property type="nucleotide sequence ID" value="XM_018432828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TFR7"/>
    <dbReference type="GeneID" id="28993734"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152051"/>
    <dbReference type="InParanoid" id="A0A162TFR7"/>
    <dbReference type="OrthoDB" id="168171at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33324">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33324:SF2">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD66783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="357" mass="41126" checksum="FFAB05BD37EFB80E" modified="2016-07-06" version="1">MSTQNSAEASASQKRGLTCWNNNNVRDKPSSIQILIDWLTNAANYSCWKGRNSSRKTKETFCSEIKAIMVENDITHRSNSDIRSKIQYLHDKFKDATDFINGISQEILNDVDKNGNPTAAAEKMLRVIEWFDVMISRPSTVAPFPISNGNPTYVSNVFERAYQYDKEATQVEVDGGKGIQNILDVHNAQDFQDVLNVQDFEQFEMTFPVEHLSAASNYQRPSKRAQKTVDSSISDIIEESIKMNHEHFNLMQKKFKAEEEFHERQLQHQKDIHDYKMMFKERRLEIEGKQVQNETQQAENEAKQLKNDDIQIKPQYIAKLESLRLSKEFSISLILILTFVGIVILAGKFQKVFISMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TI28</accession>
    <name>A0A162TI28_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_97742</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285373.1">
        <property type="nucleotide sequence ID" value="XM_018444032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TI28"/>
    <dbReference type="FunCoup" id="A0A162TI28">
        <property type="interactions" value="451"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TI28"/>
    <dbReference type="GeneID" id="29004937"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_97742"/>
    <dbReference type="InParanoid" id="A0A162TI28"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000559">
        <property type="entry name" value="Nuclear/nucleolar GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000001">
        <property type="entry name" value="Nucleolar GTP-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="206"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD67333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="475" mass="53810" checksum="04E906D27CF5F53B" modified="2016-07-06" version="1" fragment="single">MGQFKKEKARVSRDKSAGDDRATNLRVKGENFYRDAKKVKYVKMLKGGKATRDAQGRIVKAADFQSSEAVTARVAPNRKWFGNTRVIGQKALEDFRESLGARIQDPYQVLLKQNKLPMSLLQDPTAQGRMHILETESFKNTFGKGAQRKKPKINLGTMEEMMTKVDDTHENYKSAKDTSLLSNKIFDMVDQSRAWYLQAGQSKRIWNELYKVIDSSDVIIHVLDARDPIGTRCINVENYIRREKPHKHLIFVLNKCDLVPTWATARWVAKLSQDAPTLAFHASINNSFGKGSLIQLLRQFSGLHSDKKQISVGFIGYPNTGKSSIINTLKSKKVCTVAPIPGETKVWQYITLMKRIYLIDCPGVVPPNIGDSETDIILKGSVRTENIAAPEDTIPTILERVRPEYIKRTYDLPGWENPTDFLEQLARKTGKLVKRGEPDIHNVSVMVLNDWLRGRIPFYVAPPESIEPRESPEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TJ92</accession>
    <name>A0A162TJ92_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_118257</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Prevacuolar compartment membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285613.1">
        <property type="nucleotide sequence ID" value="XM_018428623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TJ92"/>
    <dbReference type="FunCoup" id="A0A162TJ92">
        <property type="interactions" value="265"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TJ92"/>
    <dbReference type="GeneID" id="28989529"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_118257"/>
    <dbReference type="InParanoid" id="A0A162TJ92"/>
    <dbReference type="OrthoDB" id="5227681at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034499">
        <property type="term" value="P:late endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07295">
        <property type="entry name" value="PX_Grd19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000030">
        <property type="entry name" value="Sorting nexin-3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042138">
        <property type="entry name" value="PX_Grd19_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051074">
        <property type="entry name" value="Sorting_Nexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963:SF2">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="20"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD67573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="143" mass="16878" checksum="328522F89C38F01A" modified="2016-07-06" version="1">MAGPINREQTIEERYGIPENFLEVEVKNPQTHGFGRKMYTDYEILCRTNIPAFKLKHSSARRRYSDFEWFRDVLERESTRVNIPPLPGKVFTNRFSDEVIEQRREGLERFLQIVAGHPLLQTGSKVLAAFIQDPNFSRDNYHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TK61</accession>
    <name>A0A162TK61_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_149633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287272.1">
        <property type="nucleotide sequence ID" value="XM_018432310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TK61"/>
    <dbReference type="GeneID" id="28993216"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149633"/>
    <dbReference type="InParanoid" id="A0A162TK61"/>
    <dbReference type="OrthoDB" id="10411272at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="569" mass="65394" checksum="C992E6923E70F652" modified="2016-07-06" version="1">MSIPRIPFELLYYISGFLELHDLSQAGLVCREWNTAFMEVLWDDVRICSTTDAHGFYSTLTCHTAGLRSYRKDTSRLTLHPNATDAIPKASKANIFHLLKDQTRSHKNIGIIGALKSSLKLAWETFQIFGPSRSIKPLTTDQALFILCHLPHLVHLDIASGNRINTMRFTWKDIDVLHQCLQKLETLKLGVKLDRISPQDNTMISRIDRAPKLLTLEFTSKEVDLGWLYYWENKYPNLRAITWINKRGIDTSLNLPHNEQTDTGRLMSSFRYLDTINLNYRDGHGRMTHVLLDKLHELNSPIKNISCSIKIRICDLTDGAETTDKIMMFSKTLKKLNLEIQGRSQDKLAISQALCHCPFLVDLKITAPYMTFSINHLLDNFPSLKSLNLFVRSVDIEPSRPFVTGCHGLRTFKMCNTHTVYRLFSYISRRCRRLKFLHLHGVMIPSKSGEVNNIIPIKMKYSCLDTFQMENMRFSFRANCQIYDDCEAAVLFRVLQHNPLVPGRQKNAVAWYRKYFSPGTKIVTSEWESIAEAEGDSNCKEFSDIKNEKRIILAGYVSLECGSVKNILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TVX3</accession>
    <name>A0A162TVX3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_159627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288283.1">
        <property type="nucleotide sequence ID" value="XM_018434023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TVX3"/>
    <dbReference type="GeneID" id="28994929"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159627"/>
    <dbReference type="InParanoid" id="A0A162TVX3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="78" mass="8446" checksum="704E20BD38AF6E03" modified="2016-07-06" version="1">MYVYLASSSRHCGALTHEGVLLTCGSYSQGALGHGYDDDLKDQLVLRPVKELENMFVLDIGFGGMQSSCVAVPLHQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U619</accession>
    <name>A0A162U619_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_159182</name>
        <name evidence="2" type="ORF">PHYBLDRAFT_159183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290649.1">
        <property type="nucleotide sequence ID" value="XM_018433935.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290653.1">
        <property type="nucleotide sequence ID" value="XM_018433936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U619"/>
    <dbReference type="GeneID" id="28994841"/>
    <dbReference type="GeneID" id="28994842"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159182"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159183"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="57" mass="6576" checksum="F87854DA00D05259" modified="2016-07-06" version="1">MIRHAISGYRNKEFILRRVTFINNIFSDDGLGNLMYCAIERSTVLHGILTRNTDKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U723</accession>
    <name>A0A162U723_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_65159</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290953.1">
        <property type="nucleotide sequence ID" value="XM_018441408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U723"/>
    <dbReference type="FunCoup" id="A0A162U723">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162U723"/>
    <dbReference type="GeneID" id="29002314"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65159"/>
    <dbReference type="InParanoid" id="A0A162U723"/>
    <dbReference type="OrthoDB" id="272778at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF21">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="6">
        <location>
            <begin position="284"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD72913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="334" mass="36648" checksum="2E41DEA8BF110E3D" modified="2016-07-06" version="1">MQAAVATGFYNVLVTKALILWIGGCSVVAAIFQQKMLLHLQLRPHLTVHHQFWRLLTSHCAFTNSGDLFYGMLLLYAMQVVERNFGSAKYAAFVFVALGLTSLLEVGALVLGKALGLKRIPGGPYALLFAMLYQYHRIVPVVYRLRVFGLSLNNKMIIYLLAVEMAFSQGIDTLAPAVCGLLVGMLYRSDVGHIKQWRFHRSFKSFAVQWLRPWLASAPIARSTMTMPVQQTSAGFAVDRLVSAAGLRNRQPQSTATTTEANSVRAYLDTLTGSAAVESNLAPLSEEHVALLSNMFPEHPPETVERALAAANNDVSRAVEIMLSTPAPEGSNTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UD87</accession>
    <name>A0A162UD87_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_181171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292293.1">
        <property type="nucleotide sequence ID" value="XM_018438429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UD87"/>
    <dbReference type="GeneID" id="28999335"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_181171"/>
    <dbReference type="InParanoid" id="A0A162UD87"/>
    <dbReference type="OrthoDB" id="10314651at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="661" mass="76837" checksum="0B7BF575F58D07F5" modified="2016-07-06" version="1">MAASQLPFEILTIVATFTSTQDILSCTTVCKTWTAPFQNSLWHTINIHCKEKAKYFFHALSAHQDIYEKNGHRVRSLFLARNLGMIDAELCRMQAYFTNLRCLSIQYGNICTYSQRTVGNWGLWGSLKHLEIHFPGLTKKSRAKAMFKMLSVLPGLERLIITEDYGNPNHRLTWRDMETLHSFLPRLYYFHMDVPFGAIYPEDLDKIRCLSPEPNLITVHLFNNTLSLGWLYYAAIKYPEVTNFGWKVNRKEESTLEYYENIECPYYDDPYDYSPGSPLYSDISEEDDMVFETQEEALTAFATLAQFFPRLETLAIDERQMKEWVHSVFWVTLRHFDVSPKHLRFSLGEPINAFEKSQETIDKCILACSTTIETLELEISDSHLFHTPTYFDSFSHLVHVKLKMYSVNLELDILLDNWVSLKTLSLSMDVEKISITTKIPRYPPLHGLQTIEIELAVMHSNVFTYLSSRCRQLNTMVLRQVEIQDSVSSKTGCFYFNMPHTQLKTLRMHEVSFYYLGERDQNDDVDRFVNLVTIEQDKDIVQHDDSDKSTAASLSKDDPVPHSHPLWVHICGKFKGSKAETVVWTLGKKEVESVLRYFEAFQSNSKSRGIDRKVTRSYRGLVTKDLWETDIPHGYVKLYCKYVGEYYIDNFELSNATPYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UG52</accession>
    <name>A0A162UG52_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_165965</name>
        <name evidence="2" type="ORF">PHYBLDRAFT_175945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441009">
        <property type="protein sequence ID" value="OAD65556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283596.1">
        <property type="nucleotide sequence ID" value="XM_018437606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294032.1">
        <property type="nucleotide sequence ID" value="XM_018435339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UG52"/>
    <dbReference type="GeneID" id="28996245"/>
    <dbReference type="GeneID" id="28998512"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165965"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175945"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD75992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="176" mass="19829" checksum="D1C3CAF699BFC203" modified="2016-07-06" version="1">MIFVFWPFGPLVFCSFCFFFISKFSLFSLFPTFIIFTDFLDTRVLLPSDASPSQCSSGLAKAISPKLLSTIKHSYEHDEPPSHEHIANQELSFHTSVIDMTISAPPMYSLGLQINPFASGSILSTMVRIHDAFSFCLCACGKNPYTENANTSYYPAVLTFSYVRKLVLPPMNLYQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UTU7</accession>
    <name>A0A162UTU7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cation efflux protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_108350</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295973.1">
        <property type="nucleotide sequence ID" value="XM_018428047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UTU7"/>
    <dbReference type="STRING" id="763407.A0A162UTU7"/>
    <dbReference type="GeneID" id="28988953"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_108350"/>
    <dbReference type="InParanoid" id="A0A162UTU7"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050681">
        <property type="entry name" value="CDF/SLC30A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562">
        <property type="entry name" value="CATION EFFLUX PROTEIN/ ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562:SF17">
        <property type="entry name" value="RE54080P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="11">
        <location>
            <begin position="26"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="12">
        <location>
            <begin position="280"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="153"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="155"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD77933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="40598" checksum="CD0B4130478E4265" modified="2016-07-06" version="1">MPNASSCSNITAKNSDNARSTKRKLMFATALALVFFGTELVAGYFANSLALMSDAFHLLSDVASFIVALAAIYLAEKPATKRHTYGFHRAEVIAALVSVLTIWVLTAYLVVEAIERVKRPQEIDAKLMCITASIGVAVNVVLAYVLGGHHHGHGHSHDDHDHSHGSEHDHDHDHDHNNDHEHDHSHSHSHADADTEALVNTQPSRKETNINLRAAALHVLGDLLASVGVLISSIILIFKPSYTIVDPLCTFMFSILVLYTTYHLVKDSLAVLMEGVPGNIEPEAIEKSLSQIPGVVAVHDLHIWTLSPGKSSLTAHITVSADSELSYDEVLQRSQHIVCDMYGVHHSTIQIESDQAVFTSHCKPDICNTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V5E7</accession>
    <name>A0A162V5E7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_163169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298162.1">
        <property type="nucleotide sequence ID" value="XM_018434749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V5E7"/>
    <dbReference type="GeneID" id="28995655"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_163169"/>
    <dbReference type="InParanoid" id="A0A162V5E7"/>
    <dbReference type="OrthoDB" id="2444645at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="361" mass="40926" checksum="E5012544D720A661" modified="2016-07-06" version="1">MQNTKNTLQKPNALDSPIYEKPNAYEEPDQHNPPSPTEIPNQLEDSVTISPPVITITDRPNIIMETLNETKDHEPNTPPPPYAEKQHPRPATHSSQPGFVMQPNESLSWNESSASLASSTTSSTTNTSSSNLPLGSRLSLKKRPKTEVLVFDMRKHSLVRPHLHDIYNHYTKRLVYLKVQQYSYAWGFENILYRASDKKAPSEATKIVEARRRAHQKEITLEWGDYSEGNEASLKSDGLENKTKSNFLFVYETRYEGNRVRWKRPSLISHDMVCDIRPLYLDSEEDEGRGWRRVAEFKSHGMGYFIQLGRLLVDRKIVAAVDGSELFEALLILTCSTLVDLMREVVEKAVGLGQGGVACND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V5F9</accession>
    <name>A0A162V5F9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_140145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298172.1">
        <property type="nucleotide sequence ID" value="XM_018430337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V5F9"/>
    <dbReference type="GeneID" id="28991243"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_140145"/>
    <dbReference type="InParanoid" id="A0A162V5F9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="137" mass="15951" checksum="8F24767FEEE4BC72" modified="2016-07-06" version="1">MPFPSRRQQHIKRMVQNRMENAARKNKELLVCNLDIEDLNTELEETKINSSSPILQWREGAGKEIPGVYRKDLSTTMWRKRKTEETLIENAKSNYKLEDLGFFRLTQSNTALVENTISETSQEGLFDAETESENEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WN41</accession>
    <name>A0A162WN41_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_21989</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287235.1">
        <property type="nucleotide sequence ID" value="XM_018439771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WN41"/>
    <dbReference type="STRING" id="763407.A0A162WN41"/>
    <dbReference type="GeneID" id="29000677"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_21989"/>
    <dbReference type="InParanoid" id="A0A162WN41"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000956">
        <property type="entry name" value="CAMK family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="3"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD69195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="261" mass="30042" checksum="E18D61D87A0EC018" modified="2016-07-06" version="1" fragment="single">GRYEQKHMLGKGNFGEVWLAVEKSTKKQVAVKVLKKKNFKTEDQIKHAQNEMEICKGFVKSLGHKNIVKVYEVDSDSDYIYIVMECVKGGELFDKIKKYGRIKEIDVQKWFRQLIEAMEYIHKNGIVHRDLKPENVLLDEFNNIRVCDFGFGKKCKELELLEIYCGSPYYAAPEMVSSTPYRGPPADMWSCGVMLFAMLTGHLPFHSSNPSELFRKIRTGPYSLPRYVSAEASQLIAMLLVKDPDARMTANECLGHPWFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XA33</accession>
    <name>A0A162XA33_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HpcH/HpaI aldolase/citrate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_155475</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291515.1">
        <property type="nucleotide sequence ID" value="XM_018433410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XA33"/>
    <dbReference type="STRING" id="763407.A0A162XA33"/>
    <dbReference type="GeneID" id="28994316"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_155475"/>
    <dbReference type="InParanoid" id="A0A162XA33"/>
    <dbReference type="OrthoDB" id="1773at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32308:SF0">
        <property type="entry name" value="HPCH_HPAI ALDOLASE_CITRATE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32308">
        <property type="entry name" value="LYASE BETA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="6">
        <location>
            <begin position="46"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD73475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="348" mass="38321" checksum="3037BD7FFD15562D" modified="2016-07-06" version="1">MRSLAGLVLLQRPVQSTFSITRLLARQGHATIGLRALSTRDVRPRRAMLYVPGSDERKIYKSISIGADCVVYDLEDSVPSSKKGTARHLVLDALEASEHGKAEKAVRINAIGSGLELDDLNVILHSKRLQAIVIPKVQSAKDIQFVSRMIDSVAIESQRERIRLIALVESALGIMNIREIATADPRLDALIFASEDYCADVGITRTESRKELLFARQMLVTAATAYGLQAIDLVCVDYQDQKVLLEECNEGRTFGFAGKQAIHPGQVEIIQQTFLPDPAEVERATKIIEGNEIHNAKGLGAFNLDGKMIDMPVVKWAQKILTRAKAGGMDIPIAKISGDEKQNKKKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XTM1</accession>
    <name>A0A162XTM1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_143439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294515.1">
        <property type="nucleotide sequence ID" value="XM_018430983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XTM1"/>
    <dbReference type="GeneID" id="28991889"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143439"/>
    <dbReference type="InParanoid" id="A0A162XTM1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="228" mass="26576" checksum="467012AAA7375C26" modified="2016-07-06" version="1">MPLHQKKQSYDEMKMCKVQMNRLFRADLHSNIPGFNLVKLLPFVAAIEPEHTIQSLDKNLAGSSQFDTDFRCFFTSQHLQVVHSYFLLVRGATEDNLKAHVDLNSEEEQQDFLEEEETLDEDVPEIMLSQLMPIIKLLVFNNNTLLYLENAKHKSHNFSIAEKLVYSLIFNTLKKFLAQKKKQYHIIAYQIYLHILTNEVLTYARYAKLIRVIYPPAFVLSSSALHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XWD6</accession>
    <name>A0A162XWD6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Multicopper oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_62978</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294865.1">
        <property type="nucleotide sequence ID" value="XM_018441049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XWD6"/>
    <dbReference type="STRING" id="763407.A0A162XWD6"/>
    <dbReference type="GeneID" id="29001955"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_62978"/>
    <dbReference type="InParanoid" id="A0A162XWD6"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04206">
        <property type="entry name" value="CuRO_1_LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04205">
        <property type="entry name" value="CuRO_2_LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007841099" evidence="6">
        <location>
            <begin position="26"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="40"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="205"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="485"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD76825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="633" mass="71040" checksum="81025B25055AE029" modified="2016-07-06" version="1">MRQSWPSLLLSTLWTLLLLVNLGSAKNDGRHHVKEFTLNITSIQHNPDCSNYTGNVLALNGLIPGPPIIVTKGDRVQVTVFNNLTPHTPSENVTAEEDMTSHASIHFHGIRQYGSTEADGVPFLTQIPIAPGGFYVYDFKVTNQAGTYLYHAHVGMQEMSVYGAVVVYESEEADPAQRAKLLLSESESTKQHNQLKAYGSSYDDERTIVLSEWWHRDRVEFEQYLLGPTFNGIWEAESILLNGKTVYQPIQVNPDACRGYEIIPVQKNKTYRIRVIGATAFRTLGFAIANHNLTIIEVDGEPVLPYVTSFLEVASGQRFSVLITTDQDPTDYSIGTNRRWTDGTVPATSNGYAVLRYQDNISEAAKSASPSPKRRSLWSRKLNNNTPTKSDAVLKVPKGSFVFPPETIGWIWDKLTPFYGAYHETRRPADRTIVLRSTDEKLSDGSTRWFVNGISFKDPARNYLSQVLNETRAELVAMEDEEPEYANGYDPKSGMYPVRQHEIVDFVLQSTHTATLPCRSHPWHTHGHSHWEISYGAGDYSHDEHGALRSDHPVHRDVTLVYPSTSQNYTASNPPPADGSIGCGWSKIRIFTDNPGIWALHCHNTAHMFMGMMVAIEEAPELIRETDTIHSHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YAK8</accession>
    <name>A0A162YAK8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_107057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297445.1">
        <property type="nucleotide sequence ID" value="XM_018427974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YAK8"/>
    <dbReference type="STRING" id="763407.A0A162YAK8"/>
    <dbReference type="GeneID" id="28988880"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_107057"/>
    <dbReference type="InParanoid" id="A0A162YAK8"/>
    <dbReference type="OrthoDB" id="2157641at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="14"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="247" mass="28101" checksum="3B64EA77499CDA2F" modified="2016-07-06" version="1">MHTHGSALFASQPPYLKEGVLIRKHLLESATHKAKHREWREIFVTIGQGEIKMYALHNSGEVERRLTIFLLLFQSHSQLLGTIQFSHTLSNVLPPPGYNRQRPHVFAIQQPNGGVYLFQAASQEQVNEWVATANYWAARESKEPLPGGVSNMEYGWNSCLNDVFLDLDTIERVPTGSALSDPDAVTIYDWKPPAPPMVASPLNEKEQYDSLQKHLSTLNSDINEHRELKKKILIKVRKQAYIYTCLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YAZ6</accession>
    <name>A0A162YAZ6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHYBLDRAFT_129935</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Microsome membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297505.1">
        <property type="nucleotide sequence ID" value="XM_018429318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YAZ6"/>
    <dbReference type="FunCoup" id="A0A162YAZ6">
        <property type="interactions" value="432"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162YAZ6"/>
    <dbReference type="GeneID" id="28990224"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_129935"/>
    <dbReference type="InParanoid" id="A0A162YAZ6"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="16">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAD79465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="129" mass="14182" checksum="7C73462C96C5D69A" modified="2016-07-06" version="1">MSVQLFTYEEVSTHNTRDDLYMIINNKVYDITKFVEEHPGGEEVLVDEGAKDATASFNDIGHSPEASEMLEKYYIGDVDPSSAPVKGGASNSNGEKSVSASPQGNPLRIIIPLSIILGYLYFRFFVKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YBM4</accession>
    <name>A0A162YBM4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_139594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297605.1">
        <property type="nucleotide sequence ID" value="XM_018430252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YBM4"/>
    <dbReference type="GeneID" id="28991158"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139594"/>
    <dbReference type="InParanoid" id="A0A162YBM4"/>
    <dbReference type="OrthoDB" id="2273311at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD79565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="22870" checksum="0A784E86281781B4" modified="2016-07-06" version="1">MEANSFHHFYTYQPRSFATSPSLSLNLNRNRNPNPYPYPSRIYSSPDSGGTKVVHIMHLNEESQEHIIEKISCRARLHSLLPLAFPSPTCSICSLSSDSQDHFFFTCPLKNAVWIGMWLEFFGTIPTPTALHNAFHFFFFPSSLNSSIPPSTVFGCTLLAIWRHHWTFIFDDSPFVPSAVVGTARKTLTRICQELDLDPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YHU1</accession>
    <name>A0A162YHU1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_161438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298835.1">
        <property type="nucleotide sequence ID" value="XM_018434402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YHU1"/>
    <dbReference type="GeneID" id="28995308"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161438"/>
    <dbReference type="InParanoid" id="A0A162YHU1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="106" mass="11960" checksum="37DD55D6916F8C29" modified="2016-07-06" version="1">MLCESNKEVHSICCIILMRYNDSIKVSFFISLVYTPQSNKIQTPRSRADHIIANEPVYTPASQIIRLSEKKSSCTYLKANETSNGCATGRVSLYAEVVQDIKKKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Z8U9</accession>
    <name>A0A162Z8U9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_153819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441034">
        <property type="protein sequence ID" value="OAD65081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283121.1">
        <property type="nucleotide sequence ID" value="XM_018433268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Z8U9"/>
    <dbReference type="GeneID" id="28994174"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153819"/>
    <dbReference type="InParanoid" id="A0A162Z8U9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="237" mass="26148" checksum="D21D87C32E953041" modified="2016-07-06" version="1">MFSGIESTTGRIIHSDIYGRWVNVVLCSQISCHHGTSVHHQYGTIMDCECEGDRDLAFLKGLGFCKCNLLPLLNNLLCFNVIWISGAFTTFNCMAKDAARFAKRNAFFDVKQDSRRIDGTSPCSECKIHDYILVKFVSSESMQRFVLLMWCCGLVLSVILISVKIFFTLWITVLSDAKTNVPAISVGTLKQPEAENISAGNQTTVEACVANLANSECEAEAAQVSRTLSEDSGIPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZHQ7</accession>
    <name>A0A162ZHQ7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Upf1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHYBLDRAFT_137149</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs. Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441000">
        <property type="protein sequence ID" value="OAD66841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284881.1">
        <property type="nucleotide sequence ID" value="XM_018429841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZHQ7"/>
    <dbReference type="FunCoup" id="A0A162ZHQ7">
        <property type="interactions" value="1168"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162ZHQ7"/>
    <dbReference type="GeneID" id="28990747"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_137149"/>
    <dbReference type="InParanoid" id="A0A162ZHQ7"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21407">
        <property type="entry name" value="1B_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18039">
        <property type="entry name" value="DEXXQc_UPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21400">
        <property type="entry name" value="ZBD_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000097">
        <property type="entry name" value="Regulator of nonsense transcripts 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040812">
        <property type="entry name" value="UPF1_1B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018999">
        <property type="entry name" value="UPF1_CH/ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF364">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18141">
        <property type="entry name" value="UPF1_1B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09416">
        <property type="entry name" value="UPF1_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51997">
        <property type="entry name" value="UPF1_CH_RICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Upf1" evidence="17">
        <location>
            <begin position="97"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="C3H" evidence="15">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="CC/SHH/C" evidence="15">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="C4" evidence="15">
        <location>
            <begin position="165"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1021"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="1022"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAD66841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1130" mass="126159" checksum="E7502034A975326D" modified="2016-07-06" version="1">MDHFEAASQDDFTFLEYSADTQTSQYDYNDFTQQTKTDRHDPEPDLSLAALSLGNLTQTDESENAKANGTASFVNEFQFEDTDDFDAFGEGLGPLEEKDLPSHACNYCGIHAPASVVKCVTCDRWFCNARGHTSGSHIINHLVRAKHKEVMLHPESPLGETVLECYNCGCRNVFLLGFIPAKSDTVVVLLCRQPCAAVPSSKDMNWDTTQWMPLIGDRCFLTWLVKIPSEQEQLRARQITSQQINKLEELWKENSEATLEDLEKPGVDDEPHPILLRYEDAYQYQNICGPLVKMEADYDRKLKESQTCDDIVVRWDVGLNQKNIAWFYFPKLEMGEVKLAVGDELRLRYRGELHEPWEGVGHVIKIPNNVSDEVALELRLLDRAPVECTHNFSVDFVWKSTSFDRMQLAMRTFAVDETSVSGYIYHRLLGHDVEPQVLKTQMPKRFSAPNLPELNHSQVYAVKSVLQRPLNLIQGPPGTGKTVTSASIVYHLAKMNPGQVLVCAPSNVAVDQLSEKIHQTGLKVVRVTAKSREELDSPVSFLTLHEQVLNNDTNVELQKLIMLKREQGELSASDEKKYKSLKRACEKEILQNADVICCTSVGAGDPRVSKLRFRTVLIDEATQASEPECMIPLVLGCKQVVLVGDHQQLGPVIMNKKAARAGLCQSLFERLVILGIRPIRLQVQYRMHPCLSEFPSNMFYEGTLQNGITTQERLRKNVDFPWPVPETPMMFYVNLGNEEISTSGTSYLNRTEASNCEKIVTRFMKAGILPSQIGVVTPYEGQRSYIVQYMQFNGSLRKDLYKEIEVASVDAFQGREKDYIILSCVRSNEHQGIGFLSDPRRLNVALTRAKYGVVILGNPKVLSKHPLWHHLLVHYKEKGCLVDGALNNLRVSMIQFSRPRKAYRKDDKFSQGLAHQIDAREAFSRPPLASENRRGGNGGGYDQDFMQTHGPVGYIPSDLGSFPSSQFNIPFIPSASGPFTQDLSQSSVFNRKNMRQNTITESQTSRYIPGSSTFATHSFGWQMGGPGGSGGSGSGSGSGAAAAGSANGAGGAASQNLYSSQASIGLALSQSDRLRMMTDMASQTNTQPQGMMTQDSMSYGFDDYKSQDVSSMMSQDFDLRSQASQAYTQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163A660</accession>
    <name>A0A163A660_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CCHC-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_147826</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289371.1">
        <property type="nucleotide sequence ID" value="XM_018431958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163A660"/>
    <dbReference type="GeneID" id="28992864"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_147826"/>
    <dbReference type="InParanoid" id="A0A163A660"/>
    <dbReference type="OrthoDB" id="2148641at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="880"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="556"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="685"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="714"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD71331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="911" mass="103167" checksum="59DC1E4DEA455F66" modified="2016-07-06" version="1">MRNKERQIEVLRIEQNVVSKELGRFRVCNIDTRCYYCREWAHYIYKKHFVWSAKTQEEVYDNTLESLNAGRFQINMLQTPLPGKRKERSPKLAERFEKLLESNADTSTALMTDIIAACELWKTLPSSLSGLPTIFEPIQFNPFPDAIPLSDDLSDPALILDELIMERQALCLPSTSFEVLKNMTGDILLSQTQATCKHTRPEYKSIAELEIERDILNSQMAEATKTVLEELAPALDLSWAPLSEFLQRLLVLEKERNGLMGEGCQQTVDQFAEQQKLVPFSAYWTERAVRFKKKRAKITEVEEAFDAHVDRWAAGSRAFRDEFALPGLRDICKLIEKLWDLVVPTIQHMADRIASHEKKEESHTENCRAVSASLKGLHSTKEVDDAVERIERELIERVAAYCESLEQLKASYREDCKPGTSGRLEKLANKEFRKKIKKAESGYHSLRHYFQYEVTQKIFPEALFCKFSLVCLEALMQEGEVMEAMTIESEVRRFIESNKDLVRQRQVLIEQFEKGVHTGRRELAGVLGKLFLKEGMRIQGENLALKRQDQLLKSISANTKSSKKKKKKGKTPSIDLPSPQQSPNKGPDRQVDVNPEEVPEVLLEDQTMTIEDNAVELAVEPPVELHAEVPAKVPVEQVGENDFECHEVESNSREVVAESLEAVKEPRTAKGELAVKVEVPVKAERSVEVAPQQEIDTKETLLTGRPAEPEMDEKESQGSEAGNKESTDQGYCDDNNDNNNNNDNDDDDDNDALAGVKHMSQADLLVFLRTLHSENSRLAESVRSSQQEMALLTNQYTEMMLVAQARETQMLQLYKSQQQVEMEEARRYTLSLEAKISALESQLQSGRPLGTAGFGSQDLFASYRHEMAFFQPATAWMAARCGHCGGEGHTSTECKGAFLCGTSHSEACRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AGZ2</accession>
    <name>A0A163AGZ2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_66022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291451.1">
        <property type="nucleotide sequence ID" value="XM_018441572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AGZ2"/>
    <dbReference type="GeneID" id="29002478"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_66022"/>
    <dbReference type="InParanoid" id="A0A163AGZ2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="171" mass="19411" checksum="95DA64DB9DF98C37" modified="2016-07-06" version="1">MSSKKLTASDNIIHKPRLICYRCAEESQPSLLAASKSGSEPNKVRLVCSKSQISKERWVYRQYPGSQGLDYSEVGDTRPKNSPYSYLCSKTITDILNIIEVRILSCFSQLLVRVSVISGVYPLLNIVKESLSHIFCTCLGSQHFILIQFLQKFPTQKHLRIIVLTFTNFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AH12</accession>
    <name>A0A163AH12_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_78266</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291471.1">
        <property type="nucleotide sequence ID" value="XM_018443348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AH12"/>
    <dbReference type="STRING" id="763407.A0A163AH12"/>
    <dbReference type="GeneID" id="29004253"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_78266"/>
    <dbReference type="InParanoid" id="A0A163AH12"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007841501" description="SH3 domain-containing protein" evidence="5">
        <location>
            <begin position="18"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="348"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD73431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="521" mass="57267" checksum="37DC24DFB0D67D2D" modified="2016-07-06" version="1">MYLIALILYLLIPLSNGQQCLSLANSTACPAFTNYYVSIGQASFVTYPWLANVTSIADFDLGLLSYINSSAPWQPLGCNGHVYPRFAATVTCSKLVLDYSSSLPCNLENNVLPKLLCRSTCTSNVNSILSLIQTKAVTCIGDEDGYQQILQNQRTACESTGEQSTCLDGLVNEGGCGFQNDQKSMCSYCQTVNTTLDCCKGLQCKSAADISRTHRNKLIGIIVGVLGGLLLLGLTILIWWWCFWGKKKKSQKKKKPRQGYSQAESYDMVPPTEPLGDEPPIDTWSGVPGQPGVIPAAAVMAKNNQNNIIINNSNTASNPSNINSNRNSNSNNSNTDGEIEGVSKVQTYLEGFCQVIYSKEPQHEDEILITQGDIIRMYYYFDDGWALGDNLMTCERGLFPLLCVVTMDPTEINAIFAMAELQIPQDTIPCDDQDASSEGSYRLTTSGVQKLRRSATLTNTRTPQPPEEQNILLPQRSASMHSRFRAARSSLELQRCSGEHSSSWSEIAPTASNSRTFLNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AIB0</accession>
    <name>A0A163AIB0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CYP5206 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_181310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291711.1">
        <property type="nucleotide sequence ID" value="XM_018438450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AIB0"/>
    <dbReference type="STRING" id="763407.A0A163AIB0"/>
    <dbReference type="GeneID" id="28999356"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_181310"/>
    <dbReference type="InParanoid" id="A0A163AIB0"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF11">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD73671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="532" mass="59487" checksum="C5F21F8EBB281BA7" modified="2016-07-06" version="1">MPDFSLSSLRNENINLAVVAAAATAAVAATLTATAFYSFSETKDPNLKNLKEIPEPKEKYPFIGHLISLGNRPGKQVTKWHNELGPIFKLRMGAQTWIMVSDPYLAHELFFTRGSLASSRPAHGYLRDIYSAGGCGLTFTVTSKKWHRSRSAAMALLAPKSVDPLGQDMIEEADKLTKSLLEDTAKHGSVSPSDGLYLVSYNVIMTVCFGLRTESSDDPDFRSMVHYIHQHEIYGGVSGDVGSFLPILSLAAYISGTKKKQIDFVKKNRDEVFSKLMEKGINGDKDCFVKSLHEDKAKYGLEHQDILVLLSDIIVAGTDTTALTTTWLLAIIANRPDIQRKIQAEIDDFVAKNGRLPMYSDRESFPYLAATQKEGLRLRPITEFGVPHEASEDIDLRGYHVPKNSILIGSMDAMHTNPLRYARPEEFIPERFLSYPESMATLASGSIKKRDQYNFGWGRRLCPGIYMASSYVAETEMFYNMTRIFHRCNMEPPLDVDGKPIIVDIDAFIDHGITSSPVPYKMRFVPRSEALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AK08</accession>
    <name>A0A163AK08_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Anoctamin dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_186993</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD74001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292041.1">
        <property type="nucleotide sequence ID" value="XM_018439312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AK08"/>
    <dbReference type="FunCoup" id="A0A163AK08">
        <property type="interactions" value="84"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163AK08"/>
    <dbReference type="GeneID" id="29000218"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_186993"/>
    <dbReference type="InParanoid" id="A0A163AK08"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049456">
        <property type="entry name" value="Anoctamin_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20877">
        <property type="entry name" value="Anoctamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="667"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin alpha-beta plait" evidence="7">
        <location>
            <begin position="78"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="6">
        <location>
            <begin position="253"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD74001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="771" mass="87779" checksum="A6CFDE573F1B80F9" modified="2016-07-06" version="1">MSEGASSPESQRQFSHLFPTEAIASTPPTGQCPVEQCPIEKTFVDQCPVENTFTDSCPAVPSTSTNKTSQSTYKSNAGVDFVIIFKFPTNQPDVTREQLEAKTTKALESLTTKLSKVGLRFQIRPGKERGVLLVLVGCPSNLLYQALKRERIRDFLLGVRVDDIEEDGKSRSINMSDVTDSERLRLVYDLITSPETEGGASISPDLDECVDSIMPLHDENFDKPEYYSNGSSHGRRNGCLIKTTSTKFETSLIAYYFAFLQNYFVWLSVPSVLGAFVYMTHTNTLTIGFSVFMLVWAVVYLEMWKRKEKELAVMWGVRNCSKYEKRRAEYGGDGTIKDEVTGEELPFVAPWKTIVRRILAIPGVALGAVFLSSIVGFVFFLQLFLHEYYAGPFAQILHYAPTIGYVLFIPTMTNIYNKWVKILNDWEMHKTDASWESNYTKKIFIANFLVGYLSLFITGWVYIPFGDHVLPYLSHYNISHDHKKVDFLRLRDQLVYFVVTGQVVGFATEMIVPYIMQKAMPKAQELKEKVTKGNTESSFPEDQLGTPEMSGPEAAFMKRVYKQVGLEEYNIYTDYVEMVIQFGYVSMFSTVWPLTALCCMINNWVELRSDALKICKYTRRPIPLRAEGAGPWIGNMETLVWLSSITMASFAYLFHPSTNIHSPYTPILTLLAIMVSEHLYVLLRILIQTAIEIIPSWSDVVVKKEDYKLKKVWLDRLASTSQSSVKQDANSSWNYEESHDELTKHVWSDRTSQDAQNQEGIRLVEAVFKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BC07</accession>
    <name>A0A163BC07_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CsbD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_14326</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0337 (CsbD) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297591.1">
        <property type="nucleotide sequence ID" value="XM_018430960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BC07"/>
    <dbReference type="STRING" id="763407.A0A163BC07"/>
    <dbReference type="GeneID" id="28991866"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_14326"/>
    <dbReference type="InParanoid" id="A0A163BC07"/>
    <dbReference type="OrthoDB" id="9999611at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008462">
        <property type="entry name" value="CsbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05532">
        <property type="entry name" value="CsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="Hypothetical protein YjbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CsbD-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD79551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="97" mass="9983" checksum="FE94C5F7C58672E1" modified="2016-07-06" version="1">MDPSKTNANWNKAAGSVKENVGSAIGNKNMQGEGMTQNSSGQAEEMGAKAQGYVSGLMDQAKGAVNGMVDSITGNDTSRAGSKAQELSGEAQKKWNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BFV1</accession>
    <name>A0A163BFV1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_161943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299371.1">
        <property type="nucleotide sequence ID" value="XM_018434538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BFV1"/>
    <dbReference type="GeneID" id="28995444"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161943"/>
    <dbReference type="InParanoid" id="A0A163BFV1"/>
    <dbReference type="OrthoDB" id="2286618at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="470" mass="53930" checksum="0CC793819AD2473B" modified="2016-07-06" version="1">MYKHSNLGPNYNEWLKTAHLLDPPFDYFSFAELILKDKHVTNLIYKSILTEYVKKSNKYLNEGVKSLKLFEGYMCSYHYNHLANQSRTKEDGPFGSAFKKYWIKREEERTVESIRKRQLEGTSNITNDIVSNMERIIKKSCATSPHFSVSPSTSAISSTYIADEKTETSTISSEDIASCDISPTGYAYKKYDGLNVLDLDNPDILEYMSGTLLEESGASIKSLTDPPKIELSEPCKDILNLISKSSASATCIKSQIRSFIGTNNSLDESEYADYYFAESTLHHFLQMMTSPRNPILFPMKERTAAPITAIYLLHAMFLSCNDLVSFHWIERTADITGAANWDGICFSIKDKRLTPVLIEFSGGIHFNSTTEKEQRDESKMIRNMVKLLEYAKYVKKHKSPVPQFYCRFFTNQIFFEAIFLVDEETRLVKRTFCKIPCPVTPRELKIFAENIPAMLKWKQAIINYVIESQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163CUQ9</accession>
    <name>A0A163CUQ9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_119881</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441008">
        <property type="protein sequence ID" value="OAD65720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283760.1">
        <property type="nucleotide sequence ID" value="XM_018428716.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A163CUQ9">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163CUQ9"/>
    <dbReference type="GeneID" id="28989622"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_119881"/>
    <dbReference type="InParanoid" id="A0A163CUQ9"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="518"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="582"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="691"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1100"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1129"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1170"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1209"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1237"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1362"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="84"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="764"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD65720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1388" mass="156839" checksum="0D4FD55BB41658E4" modified="2016-07-06" version="1">MSNYEELRRELTQQSRRKSVSAAELGASDDFDLTSFLTEQHEQGAAAGFHPKHMGVVWKDLVVQGLGADAKTISTNYTWIASTLQFWKWGRKSGHDFTILKGNDGFCKDGEMLLVLGRPGAGCTTLLRIIANMRASYTKIEGEVAYGGIEATEFSKYFRGEVCYNEEEDLHYPTLTTGQTLRFALKNKTPGKRLPNESRNEFINKILYMLGNMLGLTKQMNTMVGNAFVRGLSGGERKRLSIAEQMTTRSSINCWDCSTRGLDASSALDYVRSLRIMTDITHKTTISTLYQASDSIFNLFDKVMVLDEGRCIYFGPTETAKSFFQDMGFHCPSRKSTPDFLTGLCNANEREFRAGFEGKTPINSVQFEKAYKESDVYRSMMQERDEYEAKINQDRPAEQFRQAMLDAHQKHASKRSPFTATYYAQVKSLTVRQFQLIMGDKGALISRYGGVVIKGLIMASVFYMMPTDGSGAFSRGGAFLFSLLFNALIAQSELSAFMQGRRVLEKHKGFALYHPSAFYISQVIVDIPLAIVQVLIFELCVYFMMGLVLDAGKFFTFFVILVVTNICMNGFFRFWGAVSPNFFTASQLSSILLIACLVYCGYQIPYKLMHPWLFWIYWINPLAYGYKALISNELTGMQFSCEGPNSVPYGPSYTDQAYKSCVLPGSKPGASSVLGDDYLSLSYGYETWQRWIDFVAVLLFFFFFTILTALAMEYVDLQKEGSITKVYKKGRAPKEISEEELLKQTNTINDNAMEAVSDGTTFSWHHMDYTVPIKGGELKLLNNIGGIVKPGNLTALMGSSGAGKTTLLDVLSMRKTIGKIEGRIYMNGEPLDIDFERITGYCEQMDVHNPNATVREALKFSAYLRQEASVPKEEKDAYVEQIIQLMEMDRIADALVGDLETGIGISVEERKRLTIATELVGKPKLLFLDEPTSGLDAQSSYNIVRFIRKLADAGWPVLCTIHQPSATLFEHFDHLLLLVRGGRTAYFGEIGKDSRTMIEYFQSNGGPQCSPSANPAEYILECVGAGTAGKATRDWADVWAGSNEAKALEAELEKIHGSINPNHSRKATTYSLSFWQQFWFVYKRMNVSWWRSPNYNMGRFFNVCFIGLISGFSFWKLGNSPADMQNRMFSVFTTLLMSNALIILAQPRFMQERMWFRREHAAKYYGWAPFALSCIFVEIPYIIFLATIFLFCFYWTAGLATDSDRIGFFYVHFIVFLLYSVSLGFTIAAFSNSPPMAAVINPFFTSILILFAGIMQPPSQMPYFWRSWMYWLDPYHYVIEGLVVNALDSVPVVCGSDDFIKVNAPPGQTCGSYFSEYFASGGLGYIGNPGATDSCDYCQYTVGNDFYETRIGWSFDNRWRDFGILCAYYIFNIVAFMFFVFLFRKAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163D0J4</accession>
    <name>A0A163D0J4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_150924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285880.1">
        <property type="nucleotide sequence ID" value="XM_018432573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163D0J4"/>
    <dbReference type="GeneID" id="28993479"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150924"/>
    <dbReference type="InParanoid" id="A0A163D0J4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="195" mass="21462" checksum="03BC6F9425C1B20B" modified="2016-07-06" version="1">MSPNKIGEIRDFEPKIPARCSSAPLALTSVPIYLSFWFGNTLGNTSVSSFSFFNLFAARALLPHTFDSTMIRDTCKINRTSGLMDGLYLLNVFVIRACLSQNIWAVQFPDMMVCSGPNVDPSTLLGTAATLIPRTTPHGCACNTSWPLQLQQWRPIFGPTLLASVQGKVPAVVTVLWSSVLELHSELKIPNRQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163D1W4</accession>
    <name>A0A163D1W4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_160230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286140.1">
        <property type="nucleotide sequence ID" value="XM_018434143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163D1W4"/>
    <dbReference type="FunCoup" id="A0A163D1W4">
        <property type="interactions" value="552"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163D1W4"/>
    <dbReference type="GeneID" id="28995049"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160230"/>
    <dbReference type="InParanoid" id="A0A163D1W4"/>
    <dbReference type="OrthoDB" id="10253125at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000002">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="9">
        <location>
            <begin position="80"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD68100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="257" mass="27850" checksum="DF81B73D019AA0D6" modified="2016-07-06" version="1">MADSAPADSGFGRGGARGGRGRGGARGRGGRRGDEKTEWVPVTKLGRLVKAGKIKSIEEIYLFSLPIKEYQIVDFFLSNLKDEVMKIMPVQKQTRAGQRTRFKAFVVIGDHDGHVGLGVKCSKEVATSIRGAIILAKLSIIPVRRGYWGSALGEPHTVPCKVTGKCGSALCRLVPAPRGTGIVAAPTPKKVLQLAGITDCYTTSRGSTRTLGNFVKATFAAIGNTYGFLTPDLWEETEFSKVPYQEFTDFLSQKQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163D5A8</accession>
    <name>A0A163D5A8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_66961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286890.1">
        <property type="nucleotide sequence ID" value="XM_018441716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163D5A8"/>
    <dbReference type="GeneID" id="29002622"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_66961"/>
    <dbReference type="InParanoid" id="A0A163D5A8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="158" mass="18352" checksum="63D7408745228B88" modified="2016-07-06" version="1">MLYEIIIIIEMKLQSVQKIKKFIQIYGNLLSCKTTGALRKVDEKSKRHLKRIIQNSFILYNQASMIWSAESCFCLKNLDESKCFFQKVGERYAEKYFIAAFKWGNGSTFIFSSQLSQNIIKDFPSFLKMEQAVTQRHMLNSGRELIILVDLTSSLSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DQM5</accession>
    <name>A0A163DQM5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_169148</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290930.1">
        <property type="nucleotide sequence ID" value="XM_018436013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DQM5"/>
    <dbReference type="STRING" id="763407.A0A163DQM5"/>
    <dbReference type="GeneID" id="28996919"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169148"/>
    <dbReference type="InParanoid" id="A0A163DQM5"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD72890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="263" mass="30219" checksum="50FEC85B25A5A4D5" modified="2016-07-06" version="1">MLPQVPHNPLFADRLPQPSSYASAPIRREYDGTRTFSYTDAYSAHIPSDFSMQNTQSPPTISHHSYQEDHPSSPFPSISTSPFHTLDPTRQYDSVEPERNQSVDPLAGRLTMRYSCRTSPIPDCDTYGHQQPQQPQQQPKRQQRQQQHSQQQQPQQHHHENKKIKVQSSTPLERPYTCLFPNCGKAFTQQGNLKTHSRKHTGERPYHCLFAGCQKAFTQLGNLKTHEKIHWPVKPYICQFEGCGKGFTQRGNLKKVKGKEITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DRB2</accession>
    <name>A0A163DRB2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_20800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291000.1">
        <property type="nucleotide sequence ID" value="XM_018439743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DRB2"/>
    <dbReference type="FunCoup" id="A0A163DRB2">
        <property type="interactions" value="295"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163DRB2"/>
    <dbReference type="GeneID" id="29000649"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_20800"/>
    <dbReference type="InParanoid" id="A0A163DRB2"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000059">
        <property type="entry name" value="N-ethylmaleimide reductase, FMN-linked"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD72960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="379" mass="42106" checksum="5F50D004772354EC" modified="2016-07-06" version="1">MATALFMPIKVGTSLLSHRVVHSPMTRLRADSEHAPSPLMAEYYEQRASEGGLIIVEGTFINEENGIFPFAPGIYNDKQIEAWKVVTKAVHNKGGIIYLQLCHPGRAAPSIFIPGKRAPVSSSAISINGKNAIGATYDVPRALEVEEISKISQAFAQAAKNSISAGFDGVEIHGSNGFLIDQFINTSSNTRTDQYGGSIENRTRFALEVVESVTKAIGDDRTGIRLSPWSGYQDMKDDTPYKTWGYISSKIQERYPKMAYLHFIEPRDDYISGPNPGVDRMKIIENDTIEPFRKAWKGPFITSGGYTTTPKRAFETAEQSNNILVSFGRSFVANPDLVLRLKNDWPLNKYDRSTFYGGDSTGYTDYSFYKSDTDNDITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DU96</accession>
    <name>A0A163DU96_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_88026</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291500.1">
        <property type="nucleotide sequence ID" value="XM_018443684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DU96"/>
    <dbReference type="STRING" id="763407.A0A163DU96"/>
    <dbReference type="GeneID" id="29004589"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_88026"/>
    <dbReference type="InParanoid" id="A0A163DU96"/>
    <dbReference type="OrthoDB" id="444135at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001209">
        <property type="entry name" value="PRK00175.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF16">
        <property type="entry name" value="SERINE O-SUCCINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="72"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD73460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="480" mass="53496" checksum="18C712C95E440973" modified="2016-07-06" version="1" fragment="single">SNPPLSFPCIDKLKSRTLELDSGPEPSYDKVVTGYETFEHNEPFLLDHGGILPRFTIAYETWGELNAKRDNAILIHTGLSASSHAKSHSKNTKPGWWEDFIGPGSPIDTNKFFVICTNVIGGCYGSTGPSSIDPADNERYATRFPILTVFDMIRAQFLLLDNLGIDRLHASVGSSMGGMQSIAAASLYPDRVKRLVSISACSRSHPYSIALRHTQRQVLMSDPNWNKGFYYKSVPPHVGMKLAREIATISYRSGPEWEQRFGRKRAHEDQSPALCPDFLIETYLDHQGERFCLQYDPNSLLYISKAMDMFDMSESSVNGLLDQRLRNTPKLEELKKRRSGRGLSENNSSDDQDNAEACRTISGNTSALEMRKKNLDVANSSANTDRKESAKSKQPLTSLTSSDPATQDLINGMRNLTMPTLVLGVQSDILFPVWQQKEIAECLRAAGNKRVTYYELDAMFGHDTFLIDRVSVGGAVKGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EBA9</accession>
    <name>A0A163EBA9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="4">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate phospho-hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_76491</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295790.1">
        <property type="nucleotide sequence ID" value="XM_018443160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EBA9"/>
    <dbReference type="STRING" id="763407.A0A163EBA9"/>
    <dbReference type="GeneID" id="29004066"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_76491"/>
    <dbReference type="InParanoid" id="A0A163EBA9"/>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000004">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD77750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="295" mass="33521" checksum="829DF74FA6EC2893" modified="2016-07-06" version="1">MSQFQSVAIGQEFTQTRRVYLEKDGQVISPFHDIPLFANGEKTVLNMIVEIPRWSNAKMEIATNEKYNPIKQDVKKGNVRFVRNCFPFNGYIWNYGAFPQTWEDPTVTHPETHARGDNDPVDVCEIGSEIGYTGQVKQVKVLGVMALLDEGETDWKILAIDVRDPMASKLNDIDDVERHLPGLVKATREWFKIYKMPDGKPANEFAFGGECKNKAFATQVIHETHEAWERLIQGVIPAKADTHTIEVTNVNVENSPYKSSKPFHKSELGQYTQINPNDSAVKGRDDAWYYVSARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167J7D7</accession>
    <name>A0A167J7D7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_176270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441029">
        <property type="protein sequence ID" value="OAD65359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283399.1">
        <property type="nucleotide sequence ID" value="XM_018437711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167J7D7"/>
    <dbReference type="GeneID" id="28998617"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176270"/>
    <dbReference type="InParanoid" id="A0A167J7D7"/>
    <dbReference type="OrthoDB" id="2288577at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="269" mass="30567" checksum="21CC37B612E6C570" modified="2016-07-06" version="1">MKKFIENSSKGDFYHTHLSTITNPSYISLFSKLTNSITGTIPFGNHQNSPSFFHLPSFLESATNPEQQTFGNEPLPPSALPLALKEATTMRKAEYDCLLKFYKIEYDDETLCSAKTMLRHRIFANDRIQKIASINLLRQVYKGGEGLIMRGSYIQAKYIETNNNSKGIYAGCIKYLFTHNFTLNPIYTDLHACHNPKHVFAFIEWYQIPCHQPKINQGIKLYDAAFLKYDYDNILPVHRILSPIPIGSHVSGSGTANVIVIPLPRKLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167J7V2</accession>
    <name>A0A167J7V2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_176203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441028">
        <property type="protein sequence ID" value="OAD65438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283478.1">
        <property type="nucleotide sequence ID" value="XM_018437684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167J7V2"/>
    <dbReference type="GeneID" id="28998590"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176203"/>
    <dbReference type="InParanoid" id="A0A167J7V2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="285" mass="31733" checksum="BE984171F425E044" modified="2016-07-06" version="1">MTGIRQIAPNPSDEYKNLLAKMKEMEKSMVDVRGELTTMHKAICAGFGQGNGPQTSASVSLDNPSVAASSIVRIPAGIASEISCENKDKVFKLIRGYMRRDKFTSNDPALVSAMPLSPNKEIVANLLSYLLPKFVGQGIKTSEFSTMVHTNFWSITRKDREDPMVRAATNARGRRAARETEHFNRRVMAYVSNKDSIDALMKRNCSGLMIESAMSEGESEDEFLGRPCKRIFNSLIFNIDEIVRANLGNNIRQLLDRNLTSLSEKPVPDDVALCFPPWTLRDGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JCW7</accession>
    <name>A0A167JCW7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_72336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441008">
        <property type="protein sequence ID" value="OAD65746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283786.1">
        <property type="nucleotide sequence ID" value="XM_018442641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JCW7"/>
    <dbReference type="FunCoup" id="A0A167JCW7">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167JCW7"/>
    <dbReference type="GeneID" id="29003547"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_72336"/>
    <dbReference type="InParanoid" id="A0A167JCW7"/>
    <dbReference type="OrthoDB" id="3338076at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070917">
        <property type="term" value="F:inositol phosphoceramide synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006673">
        <property type="term" value="P:inositol phosphoceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013862">
        <property type="entry name" value="Kei1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077:SF1">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08552">
        <property type="entry name" value="Kei1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="180" mass="20440" checksum="E2020B0436343292" modified="2016-07-06" version="1">MVAIFKSRTCCGFIPIKTGVFIITIFGILNKICAPFGLFMLQYVSADALLVYIYTLGALGAFVAGLYGYKKENYKLIQWYTIFYWVDCLVSTATTLMFAIKWFVYTDHSLPSNASDTLTQEDYDAMFRMEGMVSVTILAILRVVHIYFAIVLSIYYRTLSKTQYSKLAAAVDEDLNYTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JLR3</accession>
    <name>A0A167JLR3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_71150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441004">
        <property type="protein sequence ID" value="OAD66266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284306.1">
        <property type="nucleotide sequence ID" value="XM_018442415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JLR3"/>
    <dbReference type="STRING" id="763407.A0A167JLR3"/>
    <dbReference type="GeneID" id="29003321"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71150"/>
    <dbReference type="InParanoid" id="A0A167JLR3"/>
    <dbReference type="OrthoDB" id="10266999at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF267">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="1">
        <location>
            <begin position="29"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="290" mass="32842" checksum="4C141B357DDE78E3" modified="2016-07-06" version="1">MSISHPTLSPLLTLEAVLCDTRGGDFRAFAAYLQHTYCLENLSFWLAVECYTTHVSRSSMEKIPTAATTTATTATVSNDDSVAENTESAFDTLPTSLTGTLMEAECHAIVSMYITSDAPHEINIPCEIRLKLLDQLKQNNYHPSIFTPASNYILELMRTNSFIPWLLEPHLPDSLYSKSKSKAQIFTHTKHNPHPHPHQLQQQHQRSLSFPILTLGGRISRLKPNSRRSMSLIDDCVLDQPLLTTQPKSMLKRIKLSLFRTDLQPILDNQSSLSAEEENSRWPSWKKLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JM01</accession>
    <name>A0A167JM01_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_175333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441004">
        <property type="protein sequence ID" value="OAD66278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284318.1">
        <property type="nucleotide sequence ID" value="XM_018437471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JM01"/>
    <dbReference type="GeneID" id="28998377"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175333"/>
    <dbReference type="InParanoid" id="A0A167JM01"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="110" mass="12465" checksum="5C439304C0AECC4D" modified="2016-07-06" version="1">MAVKGKSTDYEQWFLFCHTAIFLSEDINTVKFAELILLWQSYLHSSCVYKEKAYVRTYLFPIVTSLKSSTIINTIILNSSNVKNDLVDPSLEGIQTLPLNTAVAVKASEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JRY2</accession>
    <name>A0A167JRY2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_175134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441002">
        <property type="protein sequence ID" value="OAD66586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284626.1">
        <property type="nucleotide sequence ID" value="XM_018437416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JRY2"/>
    <dbReference type="STRING" id="763407.A0A167JRY2"/>
    <dbReference type="GeneID" id="28998322"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175134"/>
    <dbReference type="InParanoid" id="A0A167JRY2"/>
    <dbReference type="OrthoDB" id="2270010at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="161" mass="18259" checksum="DCF7F732A110FF3C" modified="2016-07-06" version="1">MSTNNIQSNKNIYTLATISEALECTSVPGVITLRLDTTIKVRTSEWRDCLLEIGESCAVKWIIHNSNKQPTDITAEEAKDSDIKMCFSQEYSCHHAGTYESKAAMRKNKCSALFHVRGFFKTPEWCEITLTKDHTEHTPGDVHEDMCTLPLAKKYLNELSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K5N4</accession>
    <name>A0A167K5N4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TH1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_174370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NELF-D family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285369.1">
        <property type="nucleotide sequence ID" value="XM_018437238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K5N4"/>
    <dbReference type="STRING" id="763407.A0A167K5N4"/>
    <dbReference type="GeneID" id="28998144"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174370"/>
    <dbReference type="InParanoid" id="A0A167K5N4"/>
    <dbReference type="OrthoDB" id="511287at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032021">
        <property type="term" value="C:NELF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006942">
        <property type="entry name" value="TH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12144:SF0">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12144">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04858">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD67329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="63150" checksum="378543D73D97AC3D" modified="2016-07-06" version="1">MSLATLEDYRKVFVKEDAILEPNVYSDGLLGYLNRGGAPMDAVTTLSESYVGIPSMCNVTAESAAAIGIDTTGIMQAALKTMLVKQFNPVVFDNFFMTSENHIDPAWLQSLVDDASFRQTAYKLLEMHPRCAFLNLIVLKAAESGYRSELSSLKTSSTYLLIYNQILEESLNKFIGMDDLAVEEHLPDLVRVCCEREETYMYAQMVLYKLREEYNGQPLIRLIAELEKTASKHGRQSFVDILRASLSDAARPLAAAIKAILGSRQLTAGDIRTIYSMYYTSVPPPVHHICRFDFLEILLKAVYVPDSGPQLRPDTIDQAIFLISFAVTVKDTDNKPVLTLYLSQQSETNEVVGILKNLHVALKEKSKGADFSGAMEAILTAIRLPVGSMAVLMWVEYISIKTAYYENYYRTTEIPLPHLLLDEIADRHPLQQPFVFNVIKRCIVHRYQNFAPEILMVLQKTWVDRLLYLVQLHYTTPVLDYMKGEGQELDDSLTVHFIEKVLNMCQSPYSAVFVQSIAEIVERIKVTLHLLKDVEARVTLFFGKTQHYSLARVFINTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KCJ8</accession>
    <name>A0A167KCJ8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_72175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285805.1">
        <property type="nucleotide sequence ID" value="XM_018442611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KCJ8"/>
    <dbReference type="GeneID" id="29003517"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_72175"/>
    <dbReference type="InParanoid" id="A0A167KCJ8"/>
    <dbReference type="OrthoDB" id="2404451at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD67765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="213" mass="24258" checksum="085D7E230C3CDA54" modified="2016-07-06" version="1">MFSSNASQQRDRISTQQYQCDQCVLFFDNYQKLQNHKRIHRGDSATMTEIDQSILDDVDMYHDENDTSNEDESVSNSEYTMESMELDNTISYKCACNFEDSEGEAHIYSSSQISTNTFTKAELMSIHLSQLMLQHRIARAAYRDIVQFINTVIRDHDNIMMEPGAKISHGETVDALLKSKSSVKGHEYDVCSSGCRLYGINDDQESCVDCGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KE60</accession>
    <name>A0A167KE60_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calcineurin subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Calcineurin regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Protein phosphatase 2B regulatory subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Pp2B2</name>
        <name evidence="10" type="ORF">PHYBLDRAFT_75064</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Composed of a catalytic subunit (A) and a regulatory subunit (B).</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285925.1">
        <property type="nucleotide sequence ID" value="XM_018443046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KE60"/>
    <dbReference type="FunCoup" id="A0A167KE60">
        <property type="interactions" value="262"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167KE60"/>
    <dbReference type="GeneID" id="29003952"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_75064"/>
    <dbReference type="InParanoid" id="A0A167KE60"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000047">
        <property type="entry name" value="Calcineurin subunit B type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="130"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD67885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="173" mass="19718" checksum="7A46D820BE96CBD7" modified="2016-07-06" version="1">MGQSGSHLEDMVNSSNFSAEEIQRLYKRFMKLDKDNSGSIDKEEFLAIPQIANNPLATRMIAIFDEDGGGDVDFHEFIKGLSAFSVRGNQREKLQFAFKVYDMDRDGFISNGELFLVLKMMVGNNLKENQLQQIVDKTIMEADKDMDGKISFEEFMVMVENTDVAKQMTLESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KP04</accession>
    <name>A0A167KP04_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_63552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286579.1">
        <property type="nucleotide sequence ID" value="XM_018441138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KP04"/>
    <dbReference type="GeneID" id="29002044"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63552"/>
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    <dbReference type="OrthoDB" id="2425068at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="433" mass="50093" checksum="AFA5BA6C44BDA333" modified="2016-07-06" version="1">MHNLFLGTAKRMMEKWVADGLIDNKKLVAMQKIVENMTLLPDYTMLRSKISKGFPFMKADEWKSWCLVYSPVVLQGVLPKQKFENWMFFVNACRFLTKPNVSEDDVQSAHIALEKFGKGCERLYSKDLLSPNMHLHLHLRDTIKDFGPVYGYWLFSFERYNSVLKNINTNRRSGFEMTYMKTFIEDTRKGDFVRNFLKTSGPFNFSGIFDKLVTGYSPADSTTSTALYNWFSLPDFLDAAENPNLSIRGNEPLPPSALPLQKKAYEMMPRQEYDCLVGYYQAVYNDPTIFSCKDVIQDTAFVNDWIEMLKSVNLLGQTFKGSREGRNGAKYAYVREIQYLFVHSFSPLVSTPHHRTPQSSQHTFAYVKWYKASKETSRKIAGVEIWDVAFSLPDFQSILPVHRILLPVAIVDHTTLRNISKKLIVPLPRKLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KQN5</accession>
    <name>A0A167KQN5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Pyruvate carboxylase</fullName>
            <ecNumber evidence="4 13">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PHYBLDRAFT_37943</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>hydrogencarbonate + pyruvate + ATP = oxaloacetate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="4 13"/>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286696.1">
        <property type="nucleotide sequence ID" value="XM_018440098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KQN5"/>
    <dbReference type="FunCoup" id="A0A167KQN5">
        <property type="interactions" value="468"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167KQN5"/>
    <dbReference type="GeneID" id="29001004"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_37943"/>
    <dbReference type="InParanoid" id="A0A167KQN5"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07937">
        <property type="entry name" value="DRE_TIM_PC_TC_5S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000018">
        <property type="entry name" value="Biotin carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000033">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000012">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.600.10">
        <property type="entry name" value="pyruvate carboxylase f1077a mutant domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055268">
        <property type="entry name" value="PCB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006761">
        <property type="entry name" value="PRK09282.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009554">
        <property type="entry name" value="PRK12999.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778">
        <property type="entry name" value="PYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778:SF2">
        <property type="entry name" value="PYRUVATE CARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001594">
        <property type="entry name" value="Pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="20">
        <location>
            <begin position="21"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="19">
        <location>
            <begin position="143"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="21">
        <location>
            <begin position="559"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="18">
        <location>
            <begin position="1097"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="568"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="640"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="16">
        <location>
            <position position="737"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="767"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="769"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="902"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="17">
        <location>
            <position position="737"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-biotinyllysine" evidence="17">
        <location>
            <position position="1138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR001594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OAD68656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1175" mass="129268" checksum="81720E15602BBEF0" modified="2016-07-06" version="1">MPHAREHSVETIRRNSEVMGNLRKLMVVNRGEIAIRVFRTAHELSMRTVAIFSHEDRLSMHRYKADESYQIGQLGEFTPVAAYLAQDEIVRIAKERGVSMIHPGYGFLSENSEFARKVEAAGMTFIGPSPTVIESLGDKTKARQIAMDCKVPVVPGTPGPVEKFGDAKAFIQEYGFPIIIKAAMGGGGRGMRVVREESELEDAFSRARSEALSAFGDGTVFIERFLDKPRHIEVQLLADRAGNVVHLFERDCSVQRRHQKVVEIAPAKNLDNACREAILNDAIKIAKAVKYKNAGTAEFLVDSQNRHYFIEINPRIQVEHTITEEITGIDIVAAQIQIAAGALLPQLGLTQQRIRQRGFAIQCRVTTEDPEKNFQPDTGKIEVYRSSGGNGVRLDGGAGYAGAIITPHYDSLLVKVTCSGSTYEVARRKIVRALVEFRIRGVKTNIPFLQRLLTHDTFMTGNCWTTFIDDTPDLFRLVQYQNRAQRLLGYLGDVVINGSQVKGQVGEPSFKQEIELPTLKSNSGNKVDVSVAPTEGWRKIIVEEGPAAFAKAVRAYPGVLIMDTTWRDAHQSLLATRVRTVDLLRVAPATSHALSNAFALECWGGATFDVAMRFLFEDPWDRLMQLRAAVPNIPFQMLLRGANAVGYTSYPDNVVYEFCDKAVKAGMDVFRIFDSLNYVDNMKLGIDAVKKAGGVVEATICYTGDVSNPKKTKYDIAYYLDLTQQLVNEGIHILSIKDMAGLLKPEAAKLLVSKIRERFPDLPIHVHTHDTAGTGVASMMAAAAAGADIVDVAIDSMSGMTSQPAMGAIVAGLEQTHLGTGIRMEDIQALNSYWEQCRLLYSCFEANVKSADSGVYDHEMPGGQYTNLMFQAQQLGLGTQWKQIKKAYQEANMLCGDLVKVTPSSKVVGDFAQFMVSNNLTPEEVTERAASLSFPTSVVEFFQGYLGQPYGGFPEPLRTKIIRDLPRLDGRPGATMPALDLVKLKAELTEKYGKSIRDYDVISAALYPKVFAEYRDTVEQYGDLSVVPTRYFLAKPEIGEEFHVEIEEGKTLIIKLLAVGPINNNGKRDVYFELNGEARVVGILDKNAAVESITREKANLANPGDVPAPMSGVVVEVRAKSGAEIKAGDPICVLSAMKMETVVSAPVAGRIEYVPIQEGDSLSSGDLVARIVKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KUP4</accession>
    <name>A0A167KUP4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_172770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286969.1">
        <property type="nucleotide sequence ID" value="XM_018436871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KUP4"/>
    <dbReference type="GeneID" id="28997777"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172770"/>
    <dbReference type="InParanoid" id="A0A167KUP4"/>
    <dbReference type="OrthoDB" id="17328at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026508">
        <property type="entry name" value="TMEM164"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20948">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20948:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14808">
        <property type="entry name" value="TMEM164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="33704" checksum="7DE2A100FF1BAC5E" modified="2016-07-06" version="1">MAIISILRNTCDPVINTVERWVRWVAGELPLDTDWTQSTKGSWYIPPRQHAIEILCLSTAFACSSFYFLERTILRSGTWIQTLLATFVPLGPATLTEKLLLTSLVASLGLTLSHKIKRKNVLFMLQPCHVSALLLILVMAWPDKRSAIPQLLFNVYLHTQWGGLAALMFPDLRDHKLVGETFNFFAEHILILVAPFYMIYSGRYLVLPSTPSMALLSFSIYGFFHSPLLHFCALRSGLNLNYLFTPPPLKVLLKLGPMYRVALYSTAFVAMFATRYLIVDGIMMVLPRKPLTVFSMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KZ55</accession>
    <name>A0A167KZ55_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_149611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287248.1">
        <property type="nucleotide sequence ID" value="XM_018432304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KZ55"/>
    <dbReference type="GeneID" id="28993210"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149611"/>
    <dbReference type="InParanoid" id="A0A167KZ55"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="100" mass="11386" checksum="CB2381E8CB4DBC56" modified="2016-07-06" version="1">MPPLLCFKTLLTNNFGHLHLYGRHTVVLYASPPILFSQTLYLVLAAGASLQLSLILTINFLHSRWVSSMLPPLELPAMIFFLPYCRHLTSFHPILPTSFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LLT5</accession>
    <name>A0A167LLT5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_64202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288756.1">
        <property type="nucleotide sequence ID" value="XM_018441255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LLT5"/>
    <dbReference type="GeneID" id="29002161"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64202"/>
    <dbReference type="InParanoid" id="A0A167LLT5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="144" mass="16762" checksum="DB97DE0555F58F24" modified="2016-07-06" version="1">MTTHKRNCDFGKIDFTPFPRNYKIQWIVSMTWNATVGCVLNSKYYILFGILIPFYMGWYNNGPVLTVYASQIAVSVMEYFSGRGFLFFPLLNSLFTVHLIFSLIQTALPVTRRKTLFRSRLPPPQLIPLTVFIEMCFLLQDKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LNR5</accession>
    <name>A0A167LNR5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_64117</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288847.1">
        <property type="nucleotide sequence ID" value="XM_018441235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LNR5"/>
    <dbReference type="GeneID" id="29002141"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64117"/>
    <dbReference type="InParanoid" id="A0A167LNR5"/>
    <dbReference type="OrthoDB" id="2279781at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD70807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="135" mass="15499" checksum="AC6C06A017F135E9" modified="2016-07-06" version="1">MHYHIWLIISVVFNLKTSLLIIRPVGSRRFKTDQFCYSSKSEHSKTKSSFACPSCYDHFDDYEDLKSHVHSSHMGERNKEGKRQREDEPELTPLAAKKVSLALKEKTAILTFINYKAGMYSTGGPKLTEKSINEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LZW0</accession>
    <name>A0A167LZW0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_182267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289477.1">
        <property type="nucleotide sequence ID" value="XM_018438597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LZW0"/>
    <dbReference type="STRING" id="763407.A0A167LZW0"/>
    <dbReference type="GeneID" id="28999503"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_182267"/>
    <dbReference type="InParanoid" id="A0A167LZW0"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938:SF35">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938">
        <property type="entry name" value="RESPIRATORY COMPLEX I CHAPERONE (CIA84), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="817"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1070" mass="121453" checksum="34341C89DA3594B5" modified="2016-07-06" version="1">MSIQLSESCRRSLQHTKGLRHSLEALPLQKACIPTRRTTIEKKLQVQNISLFNRPTIQSQQLLNSSWKPLTQTRHYLKVSPQLNYEDLELKKDVGAGIISEQPIHSQPISAEDAIQQFNSRIEQCINQVEANTPLHSIEISNIWNSYNALLQYMPKMLLLKTVPLNSKSFEQLVLILESRSRETRHSKCWVRIAQAYEDSKTLNIIPSVRMSYAAMTAYGRSGRLKDATDIFERLNPIVPKAETQRGEMHERYMEACLNTGEFGKAFQVLVEIRQNQVHFSVASRCVARSVDVYLKKKNVRQAIAATKLFTAAELGSDPVSLRNITKSIWTACVDFMEEYGSMSVSKESLSFENFDVEPFLDEFSKQTPTFGFPRPIVKNTSGSYQHGRELFTASSLQLLMNLLANSRSDFIPSIRVYDTLLDIYAFEKDYASVKDVLWSIQKHHLQPTSQTTGLVLRTFSDNLSTAELQKLYNTFSKEGKLDTPIYSAFIHIYSNINTTGRAERVALEMKKMGCNVTTDLHMAIVQSHVRNGRVDRALSWLKTSEYLQTLRNQTKSLRTTNDSTILDPYAVVMEGLVSQYDIPSCLELHKSLSSGPMKAAVEMNRRIFKVMVTLACVEKNWNTCEAYITKRSIDITPITISRMVNTLLNLKKDNKYTMTGANIVRSLQSMESAASMFVSAEIISTIIRKLGERGQHEDAYHLYRWVRGEVGVGKGIRLVGSKERSSKPDIYLAMMQAATINSDIRRSERASVDMVYRARMLAPGPKNPNGRAAKRPPSLNDYNMLLNAYASRLPTPDIAHTKKTFKKMLNSGLVPDVVTYNTLIKAFVSADNLEAANQIFYTMLDAGIKPDGWTVNTIVHGLVGRKEWNTIDKFVKGLKNHGISIGIDIVTFNLIVQGFLCLDSNTVNHIRVLRTNHLWSKSRQLEKDLKSAYTLKSSVIWEIFEAAIGIKREEIEKEATRETVHRLSTDPIKTFDISDNHIFYKTLYQQIPRHHKSSVENTSEDSLTSSQDQVSDLKKGTISSMFTKSRSLRELKPDAVTYKLFMKAFESAGDYVAASHIHIWMTRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M2X0</accession>
    <name>A0A167M2X0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_70059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289649.1">
        <property type="nucleotide sequence ID" value="XM_018442207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M2X0"/>
    <dbReference type="GeneID" id="29003113"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70059"/>
    <dbReference type="InParanoid" id="A0A167M2X0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="168" mass="19011" checksum="A0549F01CF0C8A36" modified="2016-07-06" version="1">MNNTDYTILQILQGMQETLFALQKGQEELQIRQDALKKDMNGQESPEPAIVHNNLSGAIPRPVPNIKDITLVHIYRMMSHNLGVELDKGNKAILHSCTGFVCDELATLPSVQALGQYPNWSTISQENKNWACTRHACLLRSNGIDFTRCHKNWASVAKVSQLWKNRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MS62</accession>
    <name>A0A167MS62_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_177523</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291804.1">
        <property type="nucleotide sequence ID" value="XM_018437898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MS62"/>
    <dbReference type="FunCoup" id="A0A167MS62">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167MS62"/>
    <dbReference type="GeneID" id="28998804"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_177523"/>
    <dbReference type="InParanoid" id="A0A167MS62"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF16">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD73764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="313" mass="33792" checksum="26261669105B8781" modified="2016-07-06" version="1">MTLGFDDELPTDVYEFNEIRQNLVYQKSGIASILKPAPVVQNLPSFDAEGKPCFKPYVGSGKLEGKYALITGADSGIGRSIATLYALEGVAGITIVYRDEEEDADATYTKNTIEAQSKCVINLIARDVGYEKNCQEILDSHLAAFGRIDILVNNAAEQHKVVRVEDLVASTVERTFRTNVFGPIFMTKLVCNHLVAGGVVLNTASIAAYRGMDVLVDYSATKGAIVSFTRALSQQLAPRRIRVNAVAPGPVWTPLIANTFSQEEIKNFGSFPPFKRPAQPAEIAAAFVFLASDSASFITGQVIHPNGGTVVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N8M1</accession>
    <name>A0A167N8M1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_12154</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293374.1">
        <property type="nucleotide sequence ID" value="XM_018428809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N8M1"/>
    <dbReference type="STRING" id="763407.A0A167N8M1"/>
    <dbReference type="GeneID" id="28989715"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_12154"/>
    <dbReference type="InParanoid" id="A0A167N8M1"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="3"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD75334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="266" mass="29789" checksum="607CF293CF37DBBE" modified="2016-07-06" version="1" fragment="single">NTIRLVDIIGTGAYGVVFIGQHIHTNQRYAVKWVLGTKTTENEISIHSQLPSHQNVLSLVLVTTEPAGVFIVLEYAPGGDLFAAITKAHEIVGDNHAIRHVFLQILSAVQHCHQNGVFHRDLKPENVLLFPNLLVKLADFGLATTRTVSADFGCGSIFYYSPECQGASFRKDQKRKAYGCQQSDVWSLGVILINLVVGRNPWKEANLQDPTFKAYVRKPRHFFRSILPVISDELDSILSRIFCIDPARRISLPELRILILGCRTFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N8N2</accession>
    <name>A0A167N8N2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cullin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_166592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293379.1">
        <property type="nucleotide sequence ID" value="XM_018435439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N8N2"/>
    <dbReference type="FunCoup" id="A0A167N8N2">
        <property type="interactions" value="477"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167N8N2"/>
    <dbReference type="GeneID" id="28996345"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166592"/>
    <dbReference type="InParanoid" id="A0A167N8N2"/>
    <dbReference type="OrthoDB" id="5581181at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044554">
        <property type="entry name" value="ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057975">
        <property type="entry name" value="TPR_ANAPC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25773">
        <property type="entry name" value="TPR_ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="2">
        <location>
            <begin position="193"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD75339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="433" mass="50534" checksum="DD1964F29033FDF4" modified="2016-07-06" version="1">MECIQYNLLDLIDDFPNSMSNVNDLRLEMEKYNDAKQRITEFQEEMKLRLLHQGASSVEIVRFYILCIRTFRYLDPSCELLLPVVEMMEETYRKDMVHAVVKRIREDDDNSLCPDPEDTYVFDADELGKSVSEGYYPLCEDKGEFCKDPKKEKKKESSSHYLFLVERQWLERKSLDIVAMLFTLCETQESLAKENFVKEYQDQLGKALLKDPGYDTETEIIRLEKINERLLGGAMQSCSIMIKDMEKSAQLNDRIRKSTSVWPTDFKALVLSRHYWMDPEDDIPEQTLRLDTPCIESMEIYEQKYPIIQPSRTLNWLPEQGSVTIELTFKSRTIEMSVDPITATVISQFSTKDITFTAKQIAKNIGVPSKIAFKSLVFWQQQNILAITKDHHFQLMLIMAITTTTTVQYCVYFDLVICCQNCTLYDLVYSDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NIT1</accession>
    <name>A0A167NIT1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED6</name>
        <name evidence="10" type="ORF">PHYBLDRAFT_143006</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294059.1">
        <property type="nucleotide sequence ID" value="XM_018430918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NIT1"/>
    <dbReference type="FunCoup" id="A0A167NIT1">
        <property type="interactions" value="676"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167NIT1"/>
    <dbReference type="GeneID" id="28991824"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143006"/>
    <dbReference type="InParanoid" id="A0A167NIT1"/>
    <dbReference type="OrthoDB" id="344220at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="200"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD76019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="266" mass="30378" checksum="AC5350F5742AE3A8" modified="2016-07-06" version="1">MQRFAATEDLTSVEWRDTNWLERVGGFQNQQMVLDYFAMSPFWDRQCNNQVLSMQTQYNDLRQPYEATVEALRKMTGIEFAVIHEQPPVWVIQKRYRRGPAPDDANVYQSPTIYSVIANRLLTSLFHVNSAFKETQAMMEFHPAKGYSWKANNSTNEKQPVTAIPEKTRGPQPSKLRAQENQAFRHWMDRAIEASAARIAQTRHSLDSQSVEGSSQGSKTATKIEPGSTSAITQQRDDSTGKRQRKKTDDGNSMTNKRKKKAGKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NMF7</accession>
    <name>A0A167NMF7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_132318</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="1"/>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294314.1">
        <property type="nucleotide sequence ID" value="XM_018429486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NMF7"/>
    <dbReference type="STRING" id="763407.A0A167NMF7"/>
    <dbReference type="GeneID" id="28990392"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_132318"/>
    <dbReference type="InParanoid" id="A0A167NMF7"/>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031303">
        <property type="entry name" value="C5_meth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF52">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00095">
        <property type="entry name" value="C5_MTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD76274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="454" mass="50254" checksum="5E3E1EE0440B434F" modified="2016-07-06" version="1">MENGTKLVGLDIFSGCGGLTCGMDMTGVVDTKYAIEFSQSASLSFEKNFSGSIAYNQCANVLLERAISLHSRKETPGDLKDHLGRPLRAMPAPGDVDFIYCGPPCQGFSGINRFKKADDVKNTLVCTALSYVDFYKPKYFLLENVRGLVSYKLGGEQNGQNRIKGGIEMGVLKYILRCLTSMGYQTRFSIQQAGHHGVAQSRRRLFIWGAKIGHKLPEFPQPITCFPKPASLSITLPDGTSFSYMHRTGGQAPLGAVTVGDSISELPDSKGSVGQLIQPYSRPPLTDFQKWIRLGADQLANHFTRTFTDINIERIYNIEMTPGADHSSLPHILKPWCLSHEDSAAQRHNGWKGLYGRLNFDGQFSTTLTDMSPMGKQGTIIHPNQRRVLSVREYARAQGFPDRFVFYSTSRDCSAASVKDMYRQIGNAVPVPLAFALGKELRAAIQEDWLKSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NNH2</accession>
    <name>A0A167NNH2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fumarate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PbFumHa</name>
        <name evidence="7" type="ORF">PHYBLDRAFT_28210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. In mitochondrion, catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. In cytoplasm and nucleus, involved in DNA repair in response to DNA damage: following DNA double-strand breaks (DSBs), translocates from the cytosol to the nucleus and promotes DNA repair by catalyzing the dehydration of L-malate to fumarate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294384.1">
        <property type="nucleotide sequence ID" value="XM_018439924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NNH2"/>
    <dbReference type="FunCoup" id="A0A167NNH2">
        <property type="interactions" value="469"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167NNH2"/>
    <dbReference type="GeneID" id="29000830"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_28210"/>
    <dbReference type="InParanoid" id="A0A167NNH2"/>
    <dbReference type="OrthoDB" id="1738025at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000002">
        <property type="entry name" value="Fumarate hydratase class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008909">
        <property type="entry name" value="PRK12273.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="5">
        <location>
            <begin position="39"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarase C C-terminal" evidence="6">
        <location>
            <begin position="436"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD76344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="491" mass="53069" checksum="44D4B5EA8BD9A258" modified="2016-07-06" version="1">MLRSLTSSSLKANTVRQVRLFSAASASLQKFRAERDTFGDLQVPADRYWGAQTQRSLQNFDIGGPRERMPEPLIKAFGVLKKAAATVNMTYGLDPKVGEAIQRAADEVIDGTLLEHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKSPVHPNDHVNMSQSSNDTFPTAMHVAAAVEINHRLIPALTQLRDALHAKEKEFNHIIKIGRTHLQDATPLTLGQEFSGYVQQLTFGIKRVTSSLEHLSNLAQGGTAVGTGLNTRPGFDSKVAEAISQITGLPFKTAPNKFEALAAHDAIVEAHGALNTVAVSLMKIANDIRFLGSGPRCGLGELSLPENEPGSSIMPGKVNPTQCEAMTMVCSQVMGNNTTVSIAGSNGHFELNVFKPVMIKNLIQSIRLLSDASVSFTNNCVVGIQANEKKINSIMNESLMLVTALNPYIGYDNAAKCAKKAHKEGTTLKEAAISLGVLTEEQFKEWVRPEEMLGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NNW0</accession>
    <name>A0A167NNW0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_166341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294409.1">
        <property type="nucleotide sequence ID" value="XM_018435406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NNW0"/>
    <dbReference type="GeneID" id="28996312"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166341"/>
    <dbReference type="InParanoid" id="A0A167NNW0"/>
    <dbReference type="OrthoDB" id="2290890at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="350"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="415"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD76369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="493" mass="53107" checksum="98919ADE8A4BE9FB" modified="2016-07-06" version="1">MYLPTLWNEQDIGLSSDTSPSSTATIPLSPTMTAPMDSQPFTHQPVYSDPSLNLLYSHYLSMDTPACSVSWTPQPTFTSMPSVHITPAPFSVPYFANDYQHQDLEYSYPYNNQPQHQPQPQPQHLHQHQYTQPPSPTPYYPDVSSSLSSFYYTETSQGPSPIMTRSLDIPVRTPHPPKSGSSTLASRSTKNGKQKCNSRIGGHKRTKTADSLPTMRSTEVRCAHAKYTSSSSVEGRSSSASASMPASASGSPSGRAELKNKSVDGLETELGFLRDETVSIVIVLDSLRSAFLASTSEDPMVEPNRPLAILTGISPETPVAVPRPMIDPGTARGPVTESFLGRSNYTPDMDKEVQTAYDELMSQVKQLEKKVVKLEEQVKAVHVVPSRSKRTRREIDEDNDYAEGSNSATRYAQTASSSPAASASSVSASESTSASVAAVGGAVSTSESVSASPSMSMSSNLGTCSPIGPSNSSKRHKPPFGKSGLGSSQHRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NVI4</accession>
    <name>A0A167NVI4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_165217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294738.1">
        <property type="nucleotide sequence ID" value="XM_018435182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NVI4"/>
    <dbReference type="STRING" id="763407.A0A167NVI4"/>
    <dbReference type="GeneID" id="28996088"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165217"/>
    <dbReference type="InParanoid" id="A0A167NVI4"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022111">
        <property type="entry name" value="Rhodanese_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040503">
        <property type="entry name" value="TRHO_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43846:SF1">
        <property type="entry name" value="TRNA URIDINE(34) HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43846">
        <property type="entry name" value="UPF0176 PROTEIN YCEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12368">
        <property type="entry name" value="Rhodanese_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17773">
        <property type="entry name" value="UPF0176_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="216"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="471" mass="53016" checksum="0E743A936C19F75B" modified="2016-07-06" version="1">MLRRLTLRFNSLSKRRNHSTCAHSNNQTLKSSQTTLSVRPPLLVMTHRSPRIAEFLVCHGTRLSSTVASSSVSTATTLRNSPSLDPSTFKTLSFYRFHTLAKEELGPWREQLLDDLKQWHIVGRIYLSTEGINAQLSCPEKYVDALRTYCSTVIKPRLGDTLMDLNLGTEHGQRAFRALHLVADGLDPTSYNLSNQPSHLSPAEWHKKLAEYKAKHGKDPVLIDMRNQYESHIGYFEGATRPDVDTFRGSIKAMNEIVKDVPRNQEVFMYCTGGIRCSKAGAILQSASGFETVHLVEGGVTAYGRWIQGQEEKSLFKGKNFTFDARLGETITDEVFGKCHLCGQPSSQYQNCTHASCNLLMLCCSSCSTQFLNTCGRLKCYDTVHRYRTQTHEHFKPDGPIMIDGVRAYVKEGEKNMRSDIERVVVGKSGVMCEHKYNRRIRAFEVLGEPGQVLEEWAKAGRELPPTTATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NXT7</accession>
    <name>A0A167NXT7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_103563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294886.1">
        <property type="nucleotide sequence ID" value="XM_018427773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NXT7"/>
    <dbReference type="STRING" id="763407.A0A167NXT7"/>
    <dbReference type="GeneID" id="28988679"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_103563"/>
    <dbReference type="InParanoid" id="A0A167NXT7"/>
    <dbReference type="OrthoDB" id="2288804at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="10389" checksum="BB7E1225EB438660" modified="2016-07-06" version="1" fragment="single">AKVNDESVQPRVEEIKEKLKMFERQDIFNFDETSLFYKQPPTRTISGQAVSCLKADKMRLTVGLLCNSDGSLKFDPIIIGKHAKSHCFNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P363</accession>
    <name>A0A167P363_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminotransferase class IV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_142667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295198.1">
        <property type="nucleotide sequence ID" value="XM_018430853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P363"/>
    <dbReference type="FunCoup" id="A0A167P363">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167P363"/>
    <dbReference type="GeneID" id="28991759"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_142667"/>
    <dbReference type="InParanoid" id="A0A167P363"/>
    <dbReference type="OrthoDB" id="64220at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="27048" checksum="8F5735DF7E37D397" modified="2016-07-06" version="1">MKDFSLLETILYDPQQGFYLLNLHIARLLLAINDMNKNGHDFGSVESKDIINVLQESVRGNDRYLRVRLLLSKGGVLSTSHTDLDSPKPPLSCSSLVEAAKGGAVFSIVLDNCPSDVLDNPFVTHKTTCRDVYEDARHRSHCEWNPLNDHTPFDVVLWNKLGQVTETSIANLAIGTYSNNKWHWKTPHHSSGLLQGVFRQKLLEENDVEEVMITKEDLVSAHEIYRVRLLQDVVKEAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P6N1</accession>
    <name>A0A167P6N1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDK1-type PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_60482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
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    <dbReference type="GeneID" id="29001554"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_60482"/>
    <dbReference type="InParanoid" id="A0A167P6N1"/>
    <dbReference type="OrthoDB" id="347657at2759"/>
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    </dbReference>
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        <property type="entry name" value="PDK1-typ_PH"/>
    </dbReference>
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        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDK1-type PH" evidence="1">
        <location>
            <begin position="28"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD77351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="134" mass="15247" checksum="D1BC0303FC30F15D" modified="2016-07-06" version="1">MHVCKSHYLYAALYCSTLLNNTKRVPHLYPNESILRAGKVVRRPGFFSKKRYLILTNRPRLLYMDEGKEADGSGGKLRCEIGWTPQLLPELKGKSVFCIHTPQKSYTFDDPEGHAQEWVNTINTMLVDSFGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P6Z6</accession>
    <name>A0A167P6Z6_PHYB8</name>
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        <recommendedName>
            <fullName evidence="9">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_179831</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295409.1">
        <property type="nucleotide sequence ID" value="XM_018438217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P6Z6"/>
    <dbReference type="STRING" id="763407.A0A167P6Z6"/>
    <dbReference type="GeneID" id="28999123"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179831"/>
    <dbReference type="InParanoid" id="A0A167P6Z6"/>
    <dbReference type="OrthoDB" id="377209at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12223">
        <property type="entry name" value="RRM_SR140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
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    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
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    <dbReference type="InterPro" id="IPR035009">
        <property type="entry name" value="SR140_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF0">
        <property type="entry name" value="U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="276"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="5">
        <location>
            <begin position="413"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="CID" evidence="6">
        <location>
            <begin position="522"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="86"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="223"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="674"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="760"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="674"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="779"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="822"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD77369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="839" mass="94199" checksum="347CC650480BF9AA" modified="2016-07-06" version="1">MDDRERRERSESPEESWRPLKPIPASKLQAFTVGSNKKTPFQKRKEEAEMKKKQETEEAAKVYADFVASFEEPQDYSLGTKTFIKSNTLLKGDKVMPADNLPLRYEPTSYSKPPASSTHSAPPPPSQQQQQHSHNHNHNHNHNHNHNQNHSNNYQNQSQPSSTTTKQPYKPMPFVKAGEGPKPKMRVPVLSQEDDDEEEDMIALKEAKAQKKRNLDTFLEEIKKGQEDRQDKLRSRYGKSTSSHVVTVSRGGSGSVAQEDHEPSVGSFDTGDSMTTNLYIGNINPTVDELAICQGFGKFGPIASVKIMWPRTTEEKERNRNCGFVSFMSRKDAEQALKHMDGKDFHNYAMNVGWGKAVPMPAQPIFVLNESKKALPTGLPFNAQVANAQGGGTSQPRAEVKVVKPTNIQQVKIIHRTIERVLEHGQPIEAAIMEKEKENPKFRFLFDFNSEDHIYYRWKLYSMLQGDTKSQWRSEPFQMYKGGVWWVPPDVPFDDEGMNEMMLDSDDEEKESVRENIPKGVLGKIARQRLEMMLRQVSFQRGTIARTMAFAIDHADAAEEVVETVCKSLVIPETPISTKLARLFLVSDILHNSSVHVPNAWKYRQSFETRLPPVFEHLNQVYRSMTARLKAEQVRRHISTVLGVWENWMVFPQHYIEKLSTLFMKKSIQGSEQTVAPEASTHTTASQDFGSMSLASQGTTTGLSSEPDEGVKSTITSDTAATAQKTQAKTVSADAEALPSLPVAAETAYIQEAIETAETNTTTMRVQDDDNIGGKYTEDVDGEPMGDDDVDGEPMEDDDVDGEPMEDDDVDGEPMEDESQENKNTGSSTSAHDISDMFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PL81</accession>
    <name>A0A167PL81_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA damage-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_185106</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296198.1">
        <property type="nucleotide sequence ID" value="XM_018439031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PL81"/>
    <dbReference type="FunCoup" id="A0A167PL81">
        <property type="interactions" value="921"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167PL81"/>
    <dbReference type="GeneID" id="28999937"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_185106"/>
    <dbReference type="InParanoid" id="A0A167PL81"/>
    <dbReference type="OrthoDB" id="433457at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="7">
        <location>
            <begin position="17"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="8">
        <location>
            <begin position="422"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="6">
        <location>
            <begin position="780"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD78158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1132" mass="124821" checksum="5D86235562A3CD48" modified="2016-07-06" version="1">MTYHKYVVTAQKPTATQFAVKGSFTAPNDTNLVLGKGTRIEIYTLTPDGLKPTLEFSIYGTITAMTLHVPPGRDKASLFLLTARHKYCVLNYSESSQQVLTEASGEVLMPGEMRMETGNIRTAMDPSGIYFAATLYQNILTVIIPSECARNREGTNHRRRSSLKTRESRRRHSQTKSSTPQDFVHINLADMFVVSIAFLQNSDEPTLMVLYDTPVGHRFLELFTLDLRNRELVPYKMKPERFGRDANLLIPMPAPVGGVVVISGQYIRFIHPDKNPRAIGIRPCTINSYSIMDQSGSRIMLADTDGTLYLLAVTLDNKTVDRLSLISLGQIPLPSCLVYLDNDVVFVGSTLGDSQLVHIMECDDTTSGDVQLEVLEEFPNLGPISDFCVADLDKQGHNQLITCSGVGKDSSLRIIRNGVGLNELAAIEISGVKGVWALRPLFEDVHDDMLVISFFNQTRILQLRDSTMVPVESHSGLALDQRTLVTAVMVGNLIIQVTEHSARLVESTPDGNLLDEWKAPEGTQITVASVNPTQCVLSTGFGQLIALQVSNNRFEEIGQLEHEVSCIDISPTDTSLASSVVAVGIWGNVGVLLLSLPYLNIIAEEPLAGTVMPRSILMAKFEEICYLLVALGDGQFYNFKLDSRQGKLWDKKRTFLGKQPISLGSFTSNGTTHVFAASDKPSVIHSRNQKLLYSNVNLKEVRCVTSFNSVSFPDAIALTTKEGLLIGQMEEIQKLHITKIATVDTPRRITHQESTRTFGLVTESSQQQLSSNGKPLMGGFELIDDQTFAVLDRIYFQAPERPLAVASVVFDNDANTYYVLGTGKETDAYDAVGEGRLLVFTVKDRKLDLVFQIKAHGIVENIRPMDGKVLVTSRGQINIYSWETGLSGKGYLVSECSHTTPTVTTSVASCNDMIVTGDTVCSMTALHYNPKTHTIEDLGSDEMHQQVTAVEALSQDLYIGAEREGHLFVVERSPSDSTESFQEEPLLDTVSQWHLGEMVNQFRFGSLGVDNSDPDSQTVSSSIIFVATSGSIGMIVDLSAERFNLLRQMQSNMTRIANSIGELSHADWRNWSTVDHQELSCNVIDGDLIESFLDLTPQQMQGVVDGQNGGRKLDLSIEDLCKVVEELMSIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PME4</accession>
    <name>A0A167PME4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_121817</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296254.1">
        <property type="nucleotide sequence ID" value="XM_018428832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PME4"/>
    <dbReference type="FunCoup" id="A0A167PME4">
        <property type="interactions" value="778"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167PME4"/>
    <dbReference type="GeneID" id="28989738"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_121817"/>
    <dbReference type="InParanoid" id="A0A167PME4"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000068">
        <property type="entry name" value="Chaperone protein dnaJ 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000048">
        <property type="entry name" value="DnaJ family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="133"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="133"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="376"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD78214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="44866" checksum="FCA3EA8FC86DAFEF" modified="2016-07-06" version="1">MVRETKFYDVLGVSPDVSEGELKKAYRKLALKYHPDKNPGAGDKFKEISHAYEILSDGEKRQMYDQYGEEGLNGQGAGMGGMDAEDLFSQLFGGGIFGGGGGHGGRGGRPSGPRRGKDMVHQLKVSLEDLYAGKSSKLALQKHILCPKCDGKGGKEGAVQTCRSCNGNGVRIVMRQMGPMIQQMQQPCGDCRGEGEIVNERDRCKHCVGKKIISERKILEVHIDKGMRDGQKITFQGEGDQAPNVIPGDILIAIDEKPHPRFKRQGDDLVYEARIDLLTALAGGQFAISHLDDRVLLVNVLPGEAIKPDCVKVIPNEGMPAYRHHHHGHMFVKFSVEFPQPNWATPEVIAKLDTILPSRPQMPNFGDKHVDEVVLADAEAYQTQNTQRGYEDEDEDQRGGPGVQCAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PR22</accession>
    <name>A0A167PR22_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UPF3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_121897</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RENT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296418.1">
        <property type="nucleotide sequence ID" value="XM_018428836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PR22"/>
    <dbReference type="FunCoup" id="A0A167PR22">
        <property type="interactions" value="91"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167PR22"/>
    <dbReference type="GeneID" id="28989742"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_121897"/>
    <dbReference type="InParanoid" id="A0A167PR22"/>
    <dbReference type="OrthoDB" id="18087at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12455">
        <property type="entry name" value="RRM_like_Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039722">
        <property type="entry name" value="Upf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005120">
        <property type="entry name" value="UPF3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112:SF0">
        <property type="entry name" value="FI21285P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112">
        <property type="entry name" value="UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03467">
        <property type="entry name" value="Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF3" evidence="6">
        <location>
            <begin position="58"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD78378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="237" mass="26745" checksum="28FC391D4A5CE6B3" modified="2016-07-06" version="1" fragment="single">MSTAPSVAVPVTEIPQPTEADSTTTKDKAKVLADKAKKKKREKAKKKAKRASRKNVLKTKVIVRRLPPNLPEEIFMNTVKPWTSEENVDYKYYVLGKLSKSKAKEHVFSRAYFHFKTMEAVIAFHQGFDGHIFVDSRGNESRAVVEFAPYQKIPKEQKTTDARAGTIDSDPDYYKFLLMLKAEENKSPEVKKGSDGLSQIERLENRLALVSAQTIAAEQANKPKTTPLLEHLRAQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PTK4</accession>
    <name>A0A167PTK4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_163625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296556.1">
        <property type="nucleotide sequence ID" value="XM_018434846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PTK4"/>
    <dbReference type="STRING" id="763407.A0A167PTK4"/>
    <dbReference type="GeneID" id="28995752"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_163625"/>
    <dbReference type="InParanoid" id="A0A167PTK4"/>
    <dbReference type="OrthoDB" id="3248986at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="746" mass="85835" checksum="2FC58CD0768A4EDF" modified="2016-07-06" version="1">MSNNRTRNDYIICMCTRCTVSNPSGKCQRKQNAKRHYKQYGAPVLAASAMDMRNENVDRMEIDYNSDVDVDFNVNEEDYAITLNPLIDNEYTQPIHVSLLQEDAIFFSEDAGPQSFVIDGDDIEEGGTSFGFEKDEAFEDPALSSMKMQAHQYPLNNMSVYIRFMAIFIVIFHLVFLVDNDGSILIEFCNILLSLFDLTGALPLTIDSLKHITGFNTATGGITVYVTCSKCHTIYPPNTSTKNCTFKLFTHSNTCNNALFKSTSGNRSSPVMWKEAKNAAEHTRLERSNGTRWSQLHLLTYFDPVRCTIIDPMHNLFLGTAKCMVQIWKELEYFDNQTLLAMQDLANGVVVPPDYARINKKIADGFSFMKADEWKLWCLIYSLFILKRILPVKHLSNWMFFVNACRLLTKPSVTPDDISSAHAHLQSFCKGFEKLYKEFPVTPNMHLHLHLGKCINDFGPIYAFWLFSFERYNGLLKNLDTNQKGEFEVTMMKRFLEKAYVGNYIRSFEEKFPASTVNFLHSITRSQVILEQPSSMSSLFILSTFIEYSMNPRKSVMGCEPLPSDVLSFKVEPKIVMCKEHYECLYQYYKDAYNSHNIFGHYSDCRAGQIFVNNRIIKVKQISLLGQQYFSGSYFQALFVEKKSEDISAFPGRILYLFQHTLNFGNIDVIHTFAFVEWYASYSSGNVQPLKNEKIELWQEPSSLLTYENIIPVHRLYSPVAVAKYRPTITSDFKRLVIPLPKKIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q277</accession>
    <name>A0A167Q277_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_154482</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296976.1">
        <property type="nucleotide sequence ID" value="XM_018433328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q277"/>
    <dbReference type="STRING" id="763407.A0A167Q277"/>
    <dbReference type="GeneID" id="28994234"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_154482"/>
    <dbReference type="InParanoid" id="A0A167Q277"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="3">
        <location>
            <begin position="86"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD78936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="412" mass="47102" checksum="08E949BB4DB9772E" modified="2016-07-06" version="1">MKRKTVSLKSKKEFAASEIDACNSWQVPDFSIKDIRNAIPAHCFERSTLRSFGYLFQDLLFIGLAGYSASWIDQTTSSSSPVRFLAWSTYWIVQSFFGAGLWVLGHECGHYAFSSSKFISDAVGMMIHSSLLVPYFSWKYSHSQHHKSVGHLTKDRAHPPPLRSELGLAAQTHKHKQDNYTNTDTDTDTDTDNGTHITGPHSHFEDSPIYILLGLITYISTGTIYYLLFDVPCEMNKNKWVSHFNPNCYIFTKDQYWKVHQSTAAVAAVIASLFYAGKVLGWLVVLKYYVVPYLLINCWVILVTYLQHTSQNVPRYDSSVWNFQRGAALTIDRSYGPILDYIFHHVADAHVVHHYISTIPHYHCVEATKHIKAVLGEHYMSDNTPIPKALIDTWIKCRFVEDKGGVRFYKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q359</accession>
    <name>A0A167Q359_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_164079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297027.1">
        <property type="nucleotide sequence ID" value="XM_018434929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q359"/>
    <dbReference type="GeneID" id="28995835"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164079"/>
    <dbReference type="InParanoid" id="A0A167Q359"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="171" mass="19830" checksum="6406E2373CD0DE50" modified="2016-07-06" version="1">MYEPNFKDEYKPKSKSKDNFNVFYKANYKYKGRQEKKTNRTTNTNDKDKDKGNPNSNSNITINIHIIVISLILINKNDLRIFVLGLSVGTAQVNGKATFITSTFCYIEILRESTAVCVKSLNIYFSTAYFNWVPNCHRLKYVRESEIQLSNSIVNRTILRVSWARVINELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q730</accession>
    <name>A0A167Q730_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_162263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297228.1">
        <property type="nucleotide sequence ID" value="XM_018434594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q730"/>
    <dbReference type="GeneID" id="28995500"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162263"/>
    <dbReference type="InParanoid" id="A0A167Q730"/>
    <dbReference type="OrthoDB" id="2287922at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="417" mass="45798" checksum="7C78E84FAF7FAE16" modified="2016-07-06" version="1">MNTPPPERSKPISSSPSLNTYEAPHTRPRRHTVARPESALGLLSGPAADDDEDQQETFDRISDILSTLIQEANEAVHGIESERARLIKSNNSIVPSKLPRPKRTRTPSFHARDLPEYSIPISPISPAPSPIPGTFSKRHSRSMSARPLSCPALAVRRSATPRLSKRISSPLIQQQDPLAESFKRLDSSMALVDSLSRDLASPVTQQPQSSLPLDPRFSGLLLLPLLHIPHALISMAFDSLPSQRHSSPTSLTSMLTWAFFFVLANLMVDRLVVSTAAPILWLSVRTRRLSLPGSFQPSTFPSILPPTSTSTSTSISASASRSRSLAAPSTSSFISSSSTTTNISSDCHCDTERTRKRRMSRRPSHTISTKTHKKTYSVQGPLPSPIETHVAIRRTTPQTSWSVSTEPKPRITRRCSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QD03</accession>
    <name>A0A167QD03_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Chitin synthase</fullName>
            <ecNumber evidence="2 11">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_106719</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cell membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chitin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 11"/>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297548.1">
        <property type="nucleotide sequence ID" value="XM_018427957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QD03"/>
    <dbReference type="FunCoup" id="A0A167QD03">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QD03"/>
    <dbReference type="GeneID" id="28988863"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_106719"/>
    <dbReference type="InParanoid" id="A0A167QD03"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="508"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="689"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="728"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="12">
        <location>
            <begin position="15"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD79508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="757" mass="86484" checksum="F026280F4F544736" modified="2016-07-06" version="1">MGFTEAPRRQARRYKTVRKVKLTGGNLVLENPVPTRYLNNLPRKDNKEFTHMRYTAATCDPSDFASENYRLRQNLMNRQTELFIVLTMYNEDEILFCRTMHGVMKNIANLCSRKRSKKWNENGWEKIVVCIVSDGRAKIHPRTLSVLAAMGVYQDGMAKNVVEGKPVTAHIYEHTTQLSVDSDMNFRGSEKGIVPCQILFCLKEKNQKKINSHRWFFQAFGSLLKPNVCVLLDVGTKPGGNSIYNLWRAFDINKNVAGACGEIKAMLGRGGSALLNPLVASQNFEYKMSNILDKPLESVFGHISVLPGAFSAYRYEALQNDSKGHGPLEKYFLGEKMHGSDADIFTANMYLAEDRILCYELVAKRKAAWVLHYVSSAYGETDVPDSVAEFISQRRRWLNGSFFAGIYSMVHWRKVWSSDHNIIRKFFFMIEDLYQLFNLFFSWFALGNFYLIFYIMTTSMYSDSLDPKPFSPYVASILHIVLNYVYVLLLVVQFIIAMGNRPQGFRWAYTLIMVFFALLMGYILFCTVWITFVGVRTAVDAAKGADNIILALLNEGSFKQVVISLCSTYVMYFVASVLFFDPWHMFTSFLQYIFMSPSYTNVLNIYAFCNTHDVSWGTKGDNAVSTDLGVVKAKLDKDGNNTVEVELPTEQKDLNEQYEEACLDLKKIVVVAKEHRDAKTKQEDYYKSFRTRLVVTWIITNMALVAGITNSEILQLLGTYQQRSVAYLGFILWSVAGLSAFRFIGAILYLFMKIFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QIG6</accession>
    <name>A0A167QIG6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_121388</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297784.1">
        <property type="nucleotide sequence ID" value="XM_018428797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QIG6"/>
    <dbReference type="FunCoup" id="A0A167QIG6">
        <property type="interactions" value="342"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QIG6"/>
    <dbReference type="GeneID" id="28989703"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_121388"/>
    <dbReference type="InParanoid" id="A0A167QIG6"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019413">
        <property type="term" value="P:acetate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="31"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD79744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="494" mass="53835" checksum="B6D1724FD15E96AD" modified="2016-07-06" version="1">MSNFIVEATTSKGYKINLNTGLFINNEFVAGANTIDTINPSTGELTAKVQAAEAKQVNDAVKAATDAFKNGWKQTKGSDRGALMYKLAELIDRDNEEISQIETLDNGKGITFSRFFDVKQLAVTLRYYAGWADKVHGKVIDTEGALSYTRHEPLGVCAAIIPWNFPLLMLGWKLGPALATGNTVVVKTSELTPLSALRVAALVKEAGFPPGVVNIITGYGNIAGDALSRHPDVAKVAFTGSTAVGRMVMKAAAESNLKKVTLELGGKSPNIIFNDANIDQAVKWAHKGIFFNHGQTCCAGSRVYVQEGIYEEFIEKFKAYTRLTKLGDPHEDDTYQGPQVSQVQFDRIMGYIEAGQKEGATLALGGKRWGSKGYFIEPTVFTDVKEDMTIMREEIFGPVVAVSKFVDVDDVVAKAHNTTYGLAAAVFTSDVARAIEVSNRLEAGTVWVNCYNELDYNTPFGGYHESGMGRENGVYALDNYTQIKTVKININRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QJL8</accession>
    <name>A0A167QJL8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_179262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297839.1">
        <property type="nucleotide sequence ID" value="XM_018438127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QJL8"/>
    <dbReference type="GeneID" id="28999033"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179262"/>
    <dbReference type="InParanoid" id="A0A167QJL8"/>
    <dbReference type="OrthoDB" id="2276091at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="427" mass="47672" checksum="83ED37EEF66463C5" modified="2016-07-06" version="1">MTGAFASLSHKRHRSPSTAKTPPTAPIGKLSKLKSGLSLFGRLANPFGSGTTTTNQDNSENDNEEDDNDDEWDQPKKYSLSALMHCFKSADPAASANPAASATTPHPLAGDALYEHTHYRQRSVCPAPPIYDPSPQAPLRKKSLPSILKKDPQDDHPTTPFIRHHRHTSSLQSSGLSVPSINNGRHKQSRHVRHYSHVSSSITVNSEDLTAKEFADYTGIRILSETDDDNEHTNSEDEDETKRCGCEDEGIVPVLVRGTHGRHKSCDTTTLHVNEDSQISIKSYCSMHSHDTRSLYRKPQIWDSDFWRKPGQPQPLPQQPNLGHKRSGSSIPTTPPLLSLTQETEPPIIHTMRKLNTLSTETLNQRNNNTNISQLVPPSRNCIIRKGRFEIHLESSSEPDRVELPTDECVVEWKRKQKSPLSQSTIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QLP8</accession>
    <name>A0A167QLP8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_162945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297930.1">
        <property type="nucleotide sequence ID" value="XM_018434708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QLP8"/>
    <dbReference type="GeneID" id="28995614"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162945"/>
    <dbReference type="InParanoid" id="A0A167QLP8"/>
    <dbReference type="OrthoDB" id="5577555at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD79890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="110" mass="12887" checksum="F40AB4A1A41D66EB" modified="2016-07-06" version="1">MEKKADFDSNFKVPKLCHSSYITKFQANKNLTENVCIKFGPVRALVRSMVSWSGPHSPYNDQIKGVIMRRLLRKYRFYVCLIDIFNTSKCWLSCSKISLEKNKQVNDIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QPA6</accession>
    <name>A0A167QPA6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_59048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298044.1">
        <property type="nucleotide sequence ID" value="XM_018440425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QPA6"/>
    <dbReference type="GeneID" id="29001331"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_59048"/>
    <dbReference type="InParanoid" id="A0A167QPA6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="103" mass="11786" checksum="BE6C9BB2A279DCFF" modified="2016-07-06" version="1">MNALCAHKRTSTQTHKYTGAQEYRNTSTSTQVQTYKYTTTSTTTEISTPALSPAPTSAPKNIIRKNAVHRPIHVRIYILIRIRIHTRIRIYKSDTQIDRQTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QPG9</accession>
    <name>A0A167QPG9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_130388</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298057.1">
        <property type="nucleotide sequence ID" value="XM_018429355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QPG9"/>
    <dbReference type="FunCoup" id="A0A167QPG9">
        <property type="interactions" value="551"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QPG9"/>
    <dbReference type="GeneID" id="28990261"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_130388"/>
    <dbReference type="InParanoid" id="A0A167QPG9"/>
    <dbReference type="OrthoDB" id="446113at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12344">
        <property type="entry name" value="RRM1_SECp43_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000227">
        <property type="entry name" value="mRNA binding post-transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000405">
        <property type="entry name" value="polyadenylate-binding protein RBP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF10">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="9"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="103"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="224"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="182"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD80017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="312" mass="34826" checksum="497FC184C677E64A" modified="2016-07-06" version="1">MLLINYLNGKFRMGELEPWMDEQVIRQLWFNLNEKVMVKVIRDKMTSTSAGYAFVDFGSTSSAFNALNTYNGALIPNTHKPFKLNWASGGGLIDRREDRQPEYSIFVGDLSPEVNESGLLVIFQTRYRSCKSAKIMTDPRTSMSRGYGFVRFSDPVEQQHALVEMQGVFLGSRPIRVSVATPKNSRAGHAQYPALSPTSSLPSSPSTRSPPLQQQLMFTDPTNTTVFVGGLSAPISEEGLQQYFSSFGEIIYVKIPTGKGCGFVQYVSRQSAEMAIQEMNGYQIGNSRIRLSWGRSQQTEQKPLPVPPTLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QZ13</accession>
    <name>A0A167QZ13_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_105609</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298538.1">
        <property type="nucleotide sequence ID" value="XM_018427908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QZ13"/>
    <dbReference type="STRING" id="763407.A0A167QZ13"/>
    <dbReference type="GeneID" id="28988814"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_105609"/>
    <dbReference type="InParanoid" id="A0A167QZ13"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017348">
        <property type="entry name" value="PIM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF72">
        <property type="entry name" value="CAMK PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037993">
        <property type="entry name" value="STPK_Pim-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="13"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR037993-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR037993-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD80498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="323" mass="37137" checksum="80A742B353A1E372" modified="2016-07-06" version="1">MHHRLHPGFLAKYALGEELGSGGFGFVVSAHERRTGIERAVKFIFRHKVPAHAWVRDIEEGPIPMEIYVLKNVRHPGIIGYVDSYQDESFFYLVMELHGTQWSSPLETEAFPGGVPHSPALSQTSEDSYTSSIDSPIEEYPTRVFTRRTSCDLFECIERHHNFEESLAKDIFRQIIECVAHLDSFGICHRDIKDENIVIDDRYKVKLIDFGSAVILPRHYGQNKPCLFNKFYGTISFASPEILMRQMYRAEPAEIWSLGVLLYTILFGEVPFHDPQMAISGRFAQPKIKVSSKCLHLVSCMLERSPDKRPSIHQILTHPWFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R5P9</accession>
    <name>A0A167R5P9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WDR5-like beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_120669</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298948.1">
        <property type="nucleotide sequence ID" value="XM_018428753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R5P9"/>
    <dbReference type="STRING" id="763407.A0A167R5P9"/>
    <dbReference type="GeneID" id="28989659"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_120669"/>
    <dbReference type="InParanoid" id="A0A167R5P9"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COMPASS-like H3K4 histone methylase component WDR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059122">
        <property type="entry name" value="Beta-prop_WDR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25175">
        <property type="entry name" value="Beta-prop_WDR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="WDR5-like beta-propeller" evidence="4">
        <location>
            <begin position="2"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="38"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="80"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="122"/>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
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            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="207"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD80908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="293" mass="32518" checksum="A32D175FFF8212E5" modified="2016-07-06" version="1">MSVSSVKFSPDGKWLASCSADKTVKIWHALDGKYEATLEGHTQGLSDVAWASDSQSLCSASDDKTIRIWSLSTRETAKVLRGHSNYVFCVNYNPQSNLIVSGSFDESIKIWDVKKGKCMKTLPAHSDPVSAVHFNRDGTMIVSCSHDGLIRIWDTASGQCLKTLVDDDNPPVSFVKFSPNGKYILASTLDNTLRLWNYHTGKCLKTYRGHENNKYCIFASFSVTGGKWIVSGSEDHSIYIWNLQTKEIVQKLEGHSDVVLCIACHPTMNIIASGSIDKDKSVKLWFDKSQPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R6T1</accession>
    <name>A0A167R6T1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_138531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299024.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R6T1"/>
    <dbReference type="GeneID" id="28990922"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138531"/>
    <dbReference type="InParanoid" id="A0A167R6T1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="132" mass="14392" checksum="5C1AF6BD8F7AA6FD" modified="2016-07-06" version="1">MTPSSLSPHYAAQSPSGRKPDLVAKEVLEWWQTNGKHPFIQPHISSPSNVGANSPENLPLGDKVQLIRLPVASPSAVKEFSQASSEEPAHLTTETMPHDFSELTELASNNFHFPMLVAWKNLPATVARDASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167RC57</accession>
    <name>A0A167RC57_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_178895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299364.1">
        <property type="nucleotide sequence ID" value="XM_018438059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167RC57"/>
    <dbReference type="GeneID" id="28998965"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_178895"/>
    <dbReference type="InParanoid" id="A0A167RC57"/>
    <dbReference type="OrthoDB" id="2224642at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="54" mass="6111" checksum="95261222321DFFF2" modified="2016-07-06" version="1">MLPFPTIVCPATCELCGHWMPQHSDECPRNGVHPSQWTLTINIQELDSESDTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N2V6</accession>
    <name>A0A162N2V6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPS1</name>
        <name evidence="8" type="ORF">PHYBLDRAFT_160306</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285968.1">
        <property type="nucleotide sequence ID" value="XM_018434158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N2V6"/>
    <dbReference type="FunCoup" id="A0A162N2V6">
        <property type="interactions" value="698"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162N2V6"/>
    <dbReference type="GeneID" id="28995064"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160306"/>
    <dbReference type="InParanoid" id="A0A162N2V6"/>
    <dbReference type="OrthoDB" id="9834376at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="modified residue" description="N-acetylalanine; partial" evidence="6">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD67928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="266" mass="29740" checksum="D131A6F351A2C137" modified="2016-07-06" version="1">MAVGKNKRLSKGKKGLKKKVVDPFTRKDWYDIKAPSMFEVRQAGKTLVNRTQGLRNANDSLDGRVLELSLGDLAKDETRAFRKIQLKVDEIQGKNLLTNFYGMDMTTDKLRSMVKKWQTLIEAFVDVKTTDGYLVRIFTVAFTSRRRDQVKKTTYAQSAQIRQIRKKMFEIMSEEAVVCDLKELVAKVTSSASASAQDSIAVRIEKACHGIYPLQNTYTRKVKILKAPKFDVSALLALHGGASAGDSDVGAKISKEFVEPPVLTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N3Z8</accession>
    <name>A0A162N3Z8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_150472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286328.1">
        <property type="nucleotide sequence ID" value="XM_018432481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N3Z8"/>
    <dbReference type="GeneID" id="28993387"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150472"/>
    <dbReference type="InParanoid" id="A0A162N3Z8"/>
    <dbReference type="OrthoDB" id="2267841at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="198" mass="22046" checksum="88B26C4369E86F26" modified="2016-07-06" version="1">MFPSIQMHNTDCHCTRCNNSDQGVSQVSRRTAQHHNKRARFEAEKRSMKVDTEIIPTYQSDSVEAMDGQTNSPILDTVSTFDNDVFVGNDYNGDESDTTDDNDSDDNGEEDTAKIYVGEFNNEVPFAASGIPENPVHRFIATFTVLFASCYVVNKGSVVLIEFINELLKIYGQDFQLPKSLAGLHKMTGFSSITKGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N574</accession>
    <name>A0A162N574_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vaculolar membrane protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_101810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287628.1">
        <property type="nucleotide sequence ID" value="XM_018427647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N574"/>
    <dbReference type="STRING" id="763407.A0A162N574"/>
    <dbReference type="GeneID" id="28988553"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_101810"/>
    <dbReference type="InParanoid" id="A0A162N574"/>
    <dbReference type="OrthoDB" id="431202at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022127">
        <property type="entry name" value="STIMATE/YPL162C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735:SF1">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12400">
        <property type="entry name" value="STIMATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="23054" checksum="910886C70D20A380" modified="2016-07-06" version="1" fragment="single">CKLMDGFAIFIQLCLATAAFSTLVLKRQREKPQRPVRIWAFDVSKQLVGGIVIHSLNVVAAYIFGANPDGEQSNPCVWYFLNILVDTTLGVVILWLILSGFKHITSYFSWTGFESGVYGNPPMSNQLKQWGKQLVLYILSLVLMKFVVVLLFHLCPWISDFGRWVLQWTLGNYKLQVVFVMLIFPLVMNIMQFWIVDTIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N9F1</accession>
    <name>A0A162N9F1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_174468</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441025">
        <property type="protein sequence ID" value="OAD67084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285124.1">
        <property type="nucleotide sequence ID" value="XM_018437254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N9F1"/>
    <dbReference type="STRING" id="763407.A0A162N9F1"/>
    <dbReference type="GeneID" id="28998160"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174468"/>
    <dbReference type="InParanoid" id="A0A162N9F1"/>
    <dbReference type="OrthoDB" id="306876at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="6">
        <location>
            <begin position="53"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="6">
        <location>
            <begin position="219"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD67084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="376" mass="41162" checksum="B068AC740ED9DFB9" modified="2016-07-06" version="1">MANVAEQHLPVVQKPKRANVQIVNEATSLMPSQNKSADLSLSLEPTERRKQWLGLIIMGMSAMSFSCMAMLVRISAVYFSIVDIVLARSATQLVLSLASCAVLGINPLGKYGVRKWLFFRALVGSIGLILFFYSLTRLPMLEATSLFFLGPTFTAIVSYLVLNEPYTLFDGVCSVGCLFGIILVWKPKYALGHPVADPTAGVYNMDPSQLAEDEMARSFAILCAVAGAIMSAIAYISVRKVGKGTHLMVHSVYFAVISCVLCIGGVFVMPPNTLLQEDWSSYTLLGLMALFSFAGQCFLNQGVQMVPAGLGALMRICDIVFAYLSGVFVLHEYPDSLCVSGVCLIVGMTTTLSIHKWQVQKIRALELRKQRSRERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NCL0</accession>
    <name>A0A162NCL0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4112 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_69188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286154.1">
        <property type="nucleotide sequence ID" value="XM_018442063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NCL0"/>
    <dbReference type="STRING" id="763407.A0A162NCL0"/>
    <dbReference type="GeneID" id="29002969"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_69188"/>
    <dbReference type="InParanoid" id="A0A162NCL0"/>
    <dbReference type="OrthoDB" id="2103474at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="MEMBRANE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519:SF2">
        <property type="entry name" value="PH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="23065" checksum="CFA75683E4331134" modified="2016-07-06" version="1">MMKNLAYSYMGVNEKMEQIRLKGTAKITSIEIRYPYLHYTTPHKPLSTEQKTKKLGNIKQIAHWLDSAVPGSPIPLGLDPFLSLIPFIGGFLGSLFAMYQIYLSTQFGIPLWLLLRMLLNVFIDFMLGMIPVAGSFLDMFYKANLWNAEALEDWLNNPEPILDPVTGKTTTMSTQITWSQLSNDATRLFNSYFSATTKPVKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NHZ6</accession>
    <name>A0A162NHZ6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_67635</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292478.1">
        <property type="nucleotide sequence ID" value="XM_018441829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NHZ6"/>
    <dbReference type="GeneID" id="29002735"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_67635"/>
    <dbReference type="InParanoid" id="A0A162NHZ6"/>
    <dbReference type="OrthoDB" id="2362862at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018383">
        <property type="entry name" value="UPF0324_pro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30106">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YEIH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30106:SF1">
        <property type="entry name" value="UPF0324 MEMBRANE PROTEIN FN0533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03601">
        <property type="entry name" value="Cons_hypoth698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD74438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="498" mass="55167" checksum="A6886AE30EBFAD5C" modified="2016-07-06" version="1">MQSSVKQATKEPNVFPEAPGYRNTESSSASNSPALPESKFDKYKRFLLWWNTEEWWSCWIGLIFFGCITAAVHHGIPQPEFLKWETNPFHSFNTVGNYGLIVLFFAMGAMLWLAMGATQTPHWRFYGTGYAVVFCVALLSKILASNVTLHKASIGDSIWAIVLGCVIRNMIGIFRPTLPPWLKVSQQTELYIAISLVLLCIDISVLRPLAPRAIFVSWLDTPTLFIVVAMIGWRWMGIDRQTSIIMSGATFICGSSAAIALGASMGVPYKTEMPIAIISVFTIPSIIVLPYIAKNLGLSPSVSGAWFGGCVDSTGAVIASASIYGDKEAINTSAVVKMVQNVLIGPLSVIVAWAWSRYELQTANSLNEELLRNAGDEDIELHDIPGRSRHHPRRTESVHVLLWKRFPKFVLGFIITAILFNTVVSTDPEIRLNVNDFCFYVSEWFSTLSFVSIGLGLHFNELKDNIRSLGKLCSLYLLAQIVDIVATAGLAYTAFTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PG57</accession>
    <name>A0A162PG57_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_176163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441028">
        <property type="protein sequence ID" value="OAD65396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018437678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PG57"/>
    <dbReference type="STRING" id="763407.A0A162PG57"/>
    <dbReference type="GeneID" id="28998584"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176163"/>
    <dbReference type="InParanoid" id="A0A162PG57"/>
    <dbReference type="OrthoDB" id="2379842at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22744">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="33460" checksum="C1DCC6D000AC7CE1" modified="2016-07-06" version="1">MQKIVKLEALFRSCEGSQQVANLLQKIKKVTSEFEGKTGHPSINFQASEKIKYPGRRKGGDVPNTFPKTLVGQTGGRSVFCLAGLKAMVRLRARTRDGKPAATQKTKNNKKQNKSKKEPLDLINATKEIGFKRPATAQEDYQYDYCTSVGKRIVNDVKGRFNPTADGWCGFRVLAHLIYKDQEKFPLVKRDMLATLPKYSSIYSSTFGTNVKQLEDIIKHGSDLCIINTNFIPACLDASMWFITSDCAQLAADTYTQPVCVYSDNPNTPFVLFLPFTLSKNISKHQQPLIFNHVNNNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PMQ1</accession>
    <name>A0A162PMQ1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_70687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288436.1">
        <property type="nucleotide sequence ID" value="XM_018442317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PMQ1"/>
    <dbReference type="GeneID" id="29003223"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70687"/>
    <dbReference type="InParanoid" id="A0A162PMQ1"/>
    <dbReference type="OrthoDB" id="3247418at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="578" mass="65769" checksum="9C431D5E51A3226C" modified="2016-07-06" version="1">MCFFSYNTASVTEVMSNDNDMKIGFGDDVDIEYQVEAKDLPLLAIDSLFSSESEDDDVIGAVILDISDSESEDVRVYGESDIVPGCCNFETLSGRECRNTFFLCNIKILEYPNKDLHWNNPKDGNALLSVNHECSIMLAMNIHSFQPFDGVSCPCSAIYLCINNLPTPERYNKGEYCLRWSHSRTQGISILCYFLWCSYSCCLEKLFDPIYFHLVECTVIDPMHNLYIGTAKRVMAKWRSSGLITDAHLAATRVDAENVLLSEYYTSLGTRIGRGFPFMKANEWKECEVLYQAPFGSPKMHLHLRLRESVLSFGLVYRSWLFGLERCNGFSKDYMTNRRDGFETMYMKKCLEDTYQEDFIRQTLLVIQSGHSAIILELTTSTAAAILSHINAVLGSHEIKFVIVKVNEPLLPSALPLALKGEISMEESEYEHLSSIITSQIYRSKTRNQRGSFMQALFETSDGRSTKPYVDQIQYFFVNTAVNLFASYLSQHVFACVRWYKEIMLQPRAGEGVEVKEVGFKDAIMNSILPAFRICYPVVHYSGKVTAKFLGMHASFSSWMCVNKLFAQKKCSDLSFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PP36</accession>
    <name>A0A162PP36_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MOCS2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_24704</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289626.1">
        <property type="nucleotide sequence ID" value="XM_018439852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PP36"/>
    <dbReference type="STRING" id="763407.A0A162PP36"/>
    <dbReference type="GeneID" id="29000758"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_24704"/>
    <dbReference type="InParanoid" id="A0A162PP36"/>
    <dbReference type="OrthoDB" id="5531344at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.40:FF:000002">
        <property type="entry name" value="Molybdopterin synthase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="entry name" value="Molybdopterin biosynthesis MoaE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23404">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="Molybdopterin synthase subunit MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD71586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="17115" checksum="6EDED30EC3EC794C" modified="2016-07-06" version="1">MSQYNKEYLVVTKDELPLVDTITKLVQDDSAGATTVFLGTTRDSFQGKRVLQLDYEAYELMSIKILKAIIQEARARWKIQHVAIYHRVGCVPVGQTSVIAAVSSTHRGDSINSTAYLIDELKDRCPIWKKEVYEDGSIWKGACEGSRSEKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PT67</accession>
    <name>A0A162PT67_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein sorting-associated protein 74</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_112383</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291716.1">
        <property type="nucleotide sequence ID" value="XM_018428276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PT67"/>
    <dbReference type="FunCoup" id="A0A162PT67">
        <property type="interactions" value="210"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162PT67"/>
    <dbReference type="GeneID" id="28989182"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_112383"/>
    <dbReference type="InParanoid" id="A0A162PT67"/>
    <dbReference type="OrthoDB" id="2189106at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031985">
        <property type="term" value="C:Golgi cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3630.10:FF:000004">
        <property type="entry name" value="Probable VPS74-protein involved in protein-vacuolar targeting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704:SF2">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 3 HOMOLOG SAURON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="TRANS-GOLGI PROTEIN GMX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD73676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="37445" checksum="ED4DAE2215A235CB" modified="2016-07-06" version="1">MSTITRRRVGGSSNQDDSTQEPNASTNPRDSPVTEKKIAFDPREVNESKSTPKLTLMEEVLLLGLKDKQGYLSFWNDSISYALRGCIVMELAFRGRIAMVKDPNRRKYQLADRYIEVIDDKLTGEVLLDEALKMMKTSEKMSVASWIDLMSGETWNVMKIGYQLKQVRERLAKGLVDKGVLRTEKRNFLLFDMATHPITDTAIKEEVIKRVCTMLITRVTASSIDAQSDIPHCYLRTVSMICAAYAANVLENALLYLQHDLREQAFNRVDELMNDYSTWPFAGEGAKMNIGAGKELSIEIIAAVLNVLTKMDAIVSIDILFFKIIIIIMNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q5M1</accession>
    <name>A0A162Q5M1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acetylglutamate kinase</fullName>
            <ecNumber evidence="2">2.7.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_87361</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-acetyl-L-glutamate + ATP = N-acetyl-L-glutamyl 5-phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="2"/>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298346.1">
        <property type="nucleotide sequence ID" value="XM_018443661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q5M1"/>
    <dbReference type="STRING" id="763407.A0A162Q5M1"/>
    <dbReference type="GeneID" id="29004566"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_87361"/>
    <dbReference type="InParanoid" id="A0A162Q5M1"/>
    <dbReference type="OrthoDB" id="438291at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04252">
        <property type="entry name" value="AAK_NAGK-fArgBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000046">
        <property type="entry name" value="N-acetylglutamate kinase / N-acetylglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011242">
        <property type="entry name" value="ArgB_GNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041734">
        <property type="entry name" value="NAGK-fArgBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF0">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036441">
        <property type="entry name" value="NAGK_DUF619"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="10">
        <location>
            <begin position="284"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD80306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="438" mass="48718" checksum="C17CE24BA31F39B4" modified="2016-07-06" version="1" fragment="single">ETIVKLLYNIGSRKEVEQYLRHFSSVESQKFAVIKVGGAVLTEELETLASALTFLNRVGLSPIVLHGAGPQMNDLLEKAGVEPQYEGGIRITDANTLEIARKVFMAENLKLVDALERLGTRARPIPSGVFMADYLDKSTYGYVGKITGVNKEPIESAIRAGALPILTSLAETPDGQFLNVNADVAAAELATVIEPLKIVFLNEKNGLYHGVTGEKLDVINLDEEYEDLLKEPWVRYGTKLKLTQCKELLENLPRSSSVAILSASNLHKELFTDSGAGTLIRRGHKLFKYDSLKQVDPDKLRRIMEAEDLTIKRHEQSVASYLQSLQQRQKVTIYTDEPGQVLAIIGQDLNDPSKPAVLEKFLASKTAVLNNVTDNLWSAIQKDHPKLTWKVNASEFANGMDRSWHFERSDGSLRTPQDDSTTFFYGINDPAQVKTLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q804</accession>
    <name>A0A162Q804_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_161494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298896.1">
        <property type="nucleotide sequence ID" value="XM_018434414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q804"/>
    <dbReference type="STRING" id="763407.A0A162Q804"/>
    <dbReference type="GeneID" id="28995320"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161494"/>
    <dbReference type="InParanoid" id="A0A162Q804"/>
    <dbReference type="OrthoDB" id="3248986at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="685" mass="78646" checksum="5CAB7FE40FAF464E" modified="2016-07-06" version="1">MSNNQKKDSYVICKCPDLPVAKDDAMVDLPLSQEESIFTAEDTITGAFVVDGNEIEEGDTGFDFKQEENFDETSGTLIVESVRPSSFDNMPLYIRFVAVFIVIFHLIFLVESGGSILIEFCNTLLSLCDMSGALPLMINSLKHKTGFNMATDGMTVYIACSQCHSIYPPETSQRVCTFKKFSQSAICNNNLFKVSTGNRSLPAMVYPFNSLNWANALNNTEQTHLEKENGTRWSELHWLSYFDPVRFTVIDLMHNLYLGTAKQMIQIWRKCNYINEKNQLTMQELANGIVVPCGYARITKKIANGFSFMKADKWKSWCIIYSPFVLKHVLPAKNLENWILFVDACRLLTKTSINDKEIDEAHSKLQLFCTRFQTLYGKSAVTPNMHLHLHLSKCVHDFGPIYAFWLFSFKRYNGLLKNIETNQKGGFESTMMKRFLERTYIGSFIQSFVNHLPQFAIDFLHCISNSQDQLAALHPSSTASTFSLSDFVEYSLNPRHSALGCEPLPPSVFPIKLDQRITMCKGHYECLLEFYRHAYGSHDLFGYYSNCESNQIFVNNQIEKMKRISLLGQEYSSGSYFRTYYLENNSKDKAVFPDRILYLFQHLITINETVITHTFAFVEWYSSYSSGSYQPMLNEGIELWNEPSSVLNYECIIPVHRLYSPIAIAKYRFTITSEFKHLVIPLPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q9S3</accession>
    <name>A0A162Q9S3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_72775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299306.1">
        <property type="nucleotide sequence ID" value="XM_018442713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q9S3"/>
    <dbReference type="GeneID" id="29003619"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_72775"/>
    <dbReference type="InParanoid" id="A0A162Q9S3"/>
    <dbReference type="OrthoDB" id="3247418at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="460" mass="52592" checksum="D61A1A33A0A49B51" modified="2016-07-06" version="1">MQGPKEAKTNEINHYLRPLVVELNQLYGSVVMFTAQCPSDALVCAALLLVACNIPAAYSNAVDYSGFVFSEWVHRTDAKNCCGAELWRMFSSNAQRNRLERENGVRWSELHDLVYFNLMECTVIDPIHNLYLRTAKMLIKKWRSSGLITDAHLAEMQLDANKLVLPEDYMPLGTKIGWDFPFMKANDISMAYLDEAHQSLEAFCRECEKLYKVPFLLPNIYPHLHLQETVLNFDPVYGYWLFSFERCNATSTSTVTSIQFDINAFLDSSEINFDIVKGNEPLPSSTLPLALKREISMDQSNYEYLLEYYCKTYNNQTLVYYCQADHSNNFVNNWIQIFESIDLLRQIYKSKTKNQRRSLMQALFETSDGRSIKPYAGQIQYLFVNTAVKSFASHASQHEALFPPRAGEGVEVNEVGFEDDSMTSILPVHIICYPVTVGKHLGLEGKVPICVISLPQKIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T215</accession>
    <name>A0A162T215_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Mre11 DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHYBLDRAFT_88567</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441009">
        <property type="protein sequence ID" value="OAD65622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283662.1">
        <property type="nucleotide sequence ID" value="XM_018443693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T215"/>
    <dbReference type="FunCoup" id="A0A162T215">
        <property type="interactions" value="687"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162T215"/>
    <dbReference type="GeneID" id="29004598"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_88567"/>
    <dbReference type="InParanoid" id="A0A162T215"/>
    <dbReference type="OrthoDB" id="30417at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00583">
        <property type="entry name" value="mre11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 16" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 16" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 16" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 16" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="17">
        <location>
            <begin position="286"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAD65622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="392" mass="44603" checksum="61B0F5F074D76ED7" modified="2016-07-06" version="1" fragment="single">SNSLRILIATDNHLGYLERDPIRGQDSFNTFEEILLLAAEKDVDMIILGGDLFHDSTPSVSCLTKTTEILSRHCLGDRPNSVMIASDQSVNFEGSFKSANYYNPNINISYPIFTIHGNHDRPIGISNMSALNHLANAGLINYFGYCHDPERPVLSPILLQKGDTKLALYGIGNIPDERMHRLWRTGKVVFQRAEDEGPNRWADAFSMLVLHQNRAQHGATNHVREEDIHQFLDLVFWGHEHECRLRPENCQSFEITQPGSSVATSLCQGEAVPKHVGLMTLTGHKYALEEIPLKTVRPFEFQHIALALFSEIDPQNQEECEKFLENIVNAMIERSKKRWIRDHTEEEEDAMPLPLIRLRVDYSGGYSSFNVHRFGITFSDKVANPKDILQFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TGL4</accession>
    <name>A0A162TGL4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycosyltransferase family 71 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_160169</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286462.1">
        <property type="nucleotide sequence ID" value="XM_018434129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TGL4"/>
    <dbReference type="STRING" id="763407.A0A162TGL4"/>
    <dbReference type="GeneID" id="28995035"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160169"/>
    <dbReference type="InParanoid" id="A0A162TGL4"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000033">
        <property type="term" value="F:alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392:SF1">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD68422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="561" mass="65140" checksum="1AC1BDD042EF5AD3" modified="2016-07-06" version="1">MVMQAFSRMRPLRISAIIVVSISAFFIIYLSFGSFSRPGNINAHLSLPTQDPETLKRLAEEDQRRREEEQKFLEEERRLTRLRWIENHRSVIEPVIKATTKDIDQLVISHDIAITNPINPWTDADKRLLETSLGQKLLADLFTIPEPIPNFKTLTFQQRVYKGLFQYLDPIITEGQIDVTTDPTYSSTWDLFQKLENTLYPWISPHWENSFHINNNTRGRGIVICVGNNQFKYAATTIRGIRQVLHSNLPIEVFYIRENDLSPIKRQYLETEFTDVKTRQVVHSINDRFTQFGGWAVKPYAILASSFSEVILMDADVFFFKRPDILFADAGYKKTGALFFYDRTLFSGWSKGRMWLQSFLPTGSSLLKETRWWKSTSAHEQESGVVVINKNKSLLGLLSTCKMNDKQERDKVSYQYAHGDKETFWIGFEMVQTPYSFIKSYGAVIGGLGDAGDPSMVCGNQLHLDVDQEPLWWNGGLLRDKNKWPDRYLTFTHYAQGVDWAFETSCIRETDKIRDFSAKDRKTALEYVTLDQQRRKDQNLIEKAIWKPKPKISPEDDMEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TIJ5</accession>
    <name>A0A162TIJ5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_159960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286912.1">
        <property type="nucleotide sequence ID" value="XM_018434089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TIJ5"/>
    <dbReference type="GeneID" id="28994995"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159960"/>
    <dbReference type="InParanoid" id="A0A162TIJ5"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="236" mass="26434" checksum="CEA0DF0A747C7E25" modified="2016-07-06" version="1">MSLSSVPTTPFMKDMEDIRASSGPKWSTSGPMTPLTHSMHYPSPATPQIPGAISLASTLGQPQALSGAINKPTPPLDFTNQQFPQRPLPFATPRYEEDTGPLPMTNNVRETDISSIQNEPQQNQYASVQLMQSVQPVQPTQQQQQKQQQKQQQQQEYPAFIQDIIRLKEENDRLRSFKQDVSDVFCALNFDLGGIEPKPSNIEEIVSGLKRMLLRNKPVSDGEKEKFIKIADSIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TKN0</accession>
    <name>A0A162TKN0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_149737</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287382.1">
        <property type="nucleotide sequence ID" value="XM_018432330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TKN0"/>
    <dbReference type="FunCoup" id="A0A162TKN0">
        <property type="interactions" value="686"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TKN0"/>
    <dbReference type="GeneID" id="28993236"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149737"/>
    <dbReference type="InParanoid" id="A0A162TKN0"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="25"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD69342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="274" mass="30448" checksum="AA5FE264026D4C6E" modified="2016-07-06" version="1">MAFVLEKIAKFAIPVSLAIGGIQASMYDVQGGHRAVIFDRIQGVKPVSVGEGTHFLMPWLQRAVQFDIRTKPRNISTTTGSKDMQMVSLTLRVLHRPELTQLPAIYQHLGQDYDERVLPSIGNEVLKATVAQFDASELITQREVVSAKIREDLYKRAKEFNIALEDVSITHMTFGKEFTNAVEQKQIAQQEAERAKFIVERAEQERQAAVIRAEGDAEAAILISDSLEKAGQGIIAFRRIEASKEIAQTLSKSSNVTYLPSSKGGSNMLYNLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TM22</accession>
    <name>A0A162TM22_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_149388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287642.1">
        <property type="nucleotide sequence ID" value="XM_018432266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TM22"/>
    <dbReference type="GeneID" id="28993172"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149388"/>
    <dbReference type="InParanoid" id="A0A162TM22"/>
    <dbReference type="OrthoDB" id="5562028at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="66" mass="7701" checksum="33DA22E4907661EE" modified="2016-07-06" version="1">MGCCGSKEERDEEDVNAPLLNHEATNDNRMNYQSTETIDAKKEQDFWNEVIERTTQQVSYSPYDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TPF9</accession>
    <name>A0A162TPF9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome biogenesis protein SLX9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_183176</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLX9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286793.1">
        <property type="nucleotide sequence ID" value="XM_018438727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TPF9"/>
    <dbReference type="FunCoup" id="A0A162TPF9">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TPF9"/>
    <dbReference type="GeneID" id="28999633"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_183176"/>
    <dbReference type="InParanoid" id="A0A162TPF9"/>
    <dbReference type="OrthoDB" id="18703at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028160">
        <property type="entry name" value="Slx9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31109">
        <property type="entry name" value="PROTEIN FAM207A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31109:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN SLX9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15341">
        <property type="entry name" value="SLX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD68753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="183" mass="20852" checksum="86D7289A96DCFD5C" modified="2016-07-06" version="1">MPKAQRTKSKLRSKDSSIRSRKSAVDNKQVIEKPFDNVQITTKESIVEELDNVASKNLKRKIRHDAWLEKLDTSYNAKQQQKKKADKRKNGLKTDLSSFSDILNTIKIEPKIPVQEVEAATAPAPVKPAVLPSTSFKSKKARKKAEMQEILRFQKVMQHSAFQQNPMATIRQHVQNTFANEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TPG2</accession>
    <name>A0A162TPG2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_172047</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD70032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288072.1">
        <property type="nucleotide sequence ID" value="XM_018436721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TPG2"/>
    <dbReference type="STRING" id="763407.A0A162TPG2"/>
    <dbReference type="GeneID" id="28997627"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172047"/>
    <dbReference type="InParanoid" id="A0A162TPG2"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="64"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="64"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD70032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="322" mass="36470" checksum="B57B4DD32C095B41" modified="2016-07-06" version="1">MAGNISNQSKQNKQVKQKSQESPVTPPASLGPSKLQDIADLALLTRPSSHAKRTRVRRRNPNHVPRPMNCFLVYRCEKQKEISTYCPGANHRDISKIIAKWWHEAPSSEKEFYRTLADRGKQQHSEQYPQYKYSPRSRRQKQADGTGLVKEEEHCGHMYDEFSYNLTGIILQDSSCPACPTYWQPVSENTDITGHEKSMFPGSVGLNTSTQILYYPAFQISHPLSTMYSLGYDLGLSVEDVPYTTTLGFSPSSSPDWESLQNEADTGINRSLYSGTLPFYVNESISCDSPKDTQYILKQDISDKDYLSCSFLSNIPNCMYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TTI9</accession>
    <name>A0A162TTI9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_148081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288902.1">
        <property type="nucleotide sequence ID" value="XM_018432008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TTI9"/>
    <dbReference type="GeneID" id="28992914"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148081"/>
    <dbReference type="InParanoid" id="A0A162TTI9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="168" mass="19204" checksum="699ECC5C015EF6CB" modified="2016-07-06" version="1">MFRNFVLWKYSEGNAKGRVKEYPKFCILNINIQVIIDGTGIGSSIAIDIEKKTLAESLSASTDELIKDIPEVIEEEVNVKLEQIAIVKELEQILKSNKYIHKVDNVLPDLESKERTLGFLDSLGAYGFKEEIRMCKSLFYEFCTNFVLLSFGVFNYELISLANIHTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TZD0</accession>
    <name>A0A162TZD0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_148280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD71063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289103.1">
        <property type="nucleotide sequence ID" value="XM_018432060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TZD0"/>
    <dbReference type="STRING" id="763407.A0A162TZD0"/>
    <dbReference type="GeneID" id="28992966"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148280"/>
    <dbReference type="InParanoid" id="A0A162TZD0"/>
    <dbReference type="OrthoDB" id="2445347at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="122"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD71063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="198" mass="22954" checksum="88338F8DAB5AAD73" modified="2016-07-06" version="1">MTNVGTILMAWFKYNKKHIDARKHLYYDFPSHFIWNSNQAACRALGLLINNCEWDACMEEPPAHELLSSIRQLFAVLLVFCHVSDSYALWITHHSSMMKYYLQQEDLCAKASTLPDSDLFLFNSNQRTVYNTILDPLNATKISFWFFFIDGPSGTGKTFIFNALLRKVRQKEKFALAVATSGISEWWLHNTFAFHDPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U142</accession>
    <name>A0A162U142_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_73350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290662.1">
        <property type="nucleotide sequence ID" value="XM_018442837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U142"/>
    <dbReference type="GeneID" id="29003743"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73350"/>
    <dbReference type="InParanoid" id="A0A162U142"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="258" mass="29972" checksum="D379E14044D73E5A" modified="2016-07-06" version="1">MLVNPEINSCDVSIELKNILDNCVALKELRFFDGELLFYTSIENRGSKPKEQDYQEQKHGLRVLELDNVLTSAEMFSHLSFRCRGLEYMELKSTSIQSVIGTSGRIPLLLLDMSYSSFKVLKLFDIRCTLSEDQLLESRFIKLILLSQLKDSRSSNEKKKCTDSSSADITHPFRNLTWFKLFHEIEDDVDTDMRLRQLPEQESRIISKYCRSSDLRESDNFLKTNTWLNGELSQDLESDIQDGYVELRCKKIARCHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U8S7</accession>
    <name>A0A162U8S7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_168647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291333.1">
        <property type="nucleotide sequence ID" value="XM_018435912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U8S7"/>
    <dbReference type="GeneID" id="28996818"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168647"/>
    <dbReference type="InParanoid" id="A0A162U8S7"/>
    <dbReference type="OrthoDB" id="2289846at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="270" mass="31352" checksum="A684D83D1F09485C" modified="2016-07-06" version="1">MSPRITRNAPETNGRTLRFRISTPSVLNPKKHKVYKKYGFWSTTKELVLLKEYARIFPPLCKKGQHIRAWEKVAESVNAVTPNETKLAQDSCRRKVTDLLNLYKDNYRLPATSAISDPISYKAELDKAVYIIQQKRKLYERKKAHRGKLDFDIEGRMLEIDDLIKEMETAPPNRLKELQEDLQRLCQSDANQRVGVGRPENYSHASSVVQSNAQADRGAEDVNDRNARLDFMDSQKKFQEKVLELMKTQTGFLSHIDKLLWECLEELKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UE37</accession>
    <name>A0A162UE37_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dihydrofolate synthetase</fullName>
            <ecNumber evidence="7">6.3.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_144886</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>7,8-dihydropteroate + L-glutamate + ATP = 7,8-dihydrofolate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.12" evidence="7"/>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292473.1">
        <property type="nucleotide sequence ID" value="XM_018431316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UE37"/>
    <dbReference type="FunCoup" id="A0A162UE37">
        <property type="interactions" value="224"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UE37"/>
    <dbReference type="GeneID" id="28992222"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144886"/>
    <dbReference type="InParanoid" id="A0A162UE37"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF0">
        <property type="entry name" value="DIHYDROFOLATE SYNTHETASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur ligase central" evidence="8">
        <location>
            <begin position="27"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD74433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="441" mass="48253" checksum="4119FCBD2513DC16" modified="2016-07-06" version="1">MDLGLGRIKALLNALGNPQEKLKVVHVAGTNGKGSICAYISSVLHQHEISVGRFNSPHLLEPCDSIRINEEPITQNTYVNACKHIQAVDTGAGTHATSFECQVATALWIFDQMKLDVVVIEVGMGGELDATNVFSTPLVSILTPIGWDHAGMLGGSIESITKAKAGIIKPGCPVVISPQDDPIVLDILVSCAQNLESPCVCVQSAECISQTNHGMMCRLDYVAENTLTHESWNVNHEYPIPLNGDYQRSNSATAVTVLDWLSRLDTLPNFKLDFDKLKLGMQKTTWPGRLDWITPETHPKLKRSDWDIPSVLVDGAHNPPATNALRIHVDSLCSKYHLSRVIWILGATMGKDIEVMLKTLVQPNDIVYSVPFSQPSGMPWINCVNPMDISDCAKTLAAESQGFQSLHDALVKASSVLRHGRDLVVLCGSLYLVADFYRLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UF29</accession>
    <name>A0A162UF29_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_158473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292703.1">
        <property type="nucleotide sequence ID" value="XM_018433793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UF29"/>
    <dbReference type="GeneID" id="28994699"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_158473"/>
    <dbReference type="InParanoid" id="A0A162UF29"/>
    <dbReference type="OrthoDB" id="10375735at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="193" mass="21509" checksum="FA220109529DAEC6" modified="2016-07-06" version="1">MSESADRQLIHVNAFANDEIANTSTNSDSSCEMHMRGVFSSIDSFSLRISYSTQSVIDGYAGPKDSPEPVVMEVPCNKTTNLEFSTSYAMMKPNWKQIENFVDTDTGHVSCSTLLDQVHGSNSQDTRIVLDGGMIIHCQVRNQSQSTALTETNQTPISIEFTTIEVPVGWWLNNKESFTNANQQMCGSEFIFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UGL0</accession>
    <name>A0A162UGL0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_111568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293083.1">
        <property type="nucleotide sequence ID" value="XM_018428220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UGL0"/>
    <dbReference type="STRING" id="763407.A0A162UGL0"/>
    <dbReference type="GeneID" id="28989126"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_111568"/>
    <dbReference type="InParanoid" id="A0A162UGL0"/>
    <dbReference type="OrthoDB" id="9978460at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="127" mass="14203" checksum="69B31C15EB0710B1" modified="2016-07-06" version="1" fragment="single">LERDPPPGIVCYPIDDDITQLESFIKGPPESPYEKGLFQLDITIPLQYPFSPPQIRFKTPIYHPNIDDCGRICADILKKGVSGGWKPSLNLSTTLMSLSTLMAHPNPDDPLDADIVSTHIRIYMILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UIB9</accession>
    <name>A0A162UIB9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_143676</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293473.1">
        <property type="nucleotide sequence ID" value="XM_018431039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UIB9"/>
    <dbReference type="STRING" id="763407.A0A162UIB9"/>
    <dbReference type="GeneID" id="28991945"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143676"/>
    <dbReference type="InParanoid" id="A0A162UIB9"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36721:SF15">
        <property type="entry name" value="EN_SPM-LIKE TRANSPOSON PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36721">
        <property type="entry name" value="PROLINE-RICH FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="260"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="319"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD75433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="355" mass="38226" checksum="1285C7EE0F758E67" modified="2016-07-06" version="1">MSPTQRRFIIRRAVSDESITPKTTAPLSFANNASQKTSVFTTTKAQVAPVSSAAASAKPSSKTSKTTTRSSLISKANPPSTPVVLYTSPTSSPTARSTNSALAAGSDSGSGGISGGGIAGIVIGVLAVVAIIAFALVRRRRRNIREDQRNSRFFNTPSNVTPAIVHGYASNLQSPYSEKQNTISVSPYSIKQQQQQQTAISMPPATLQNNYNNINNQHTNQESMMYSNQSNFVTPIPITQEKAVSTPAPEETGAADVWQHPIGTFTVITTFMPSLNDELTILPGDRVKLFVEYDDGWCLGVNESRGNAQGVFPLHCIREPPQESRPNSSMAMTVPSVSDDHRLSKRGSSVLRQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UP04</accession>
    <name>A0A162UP04_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_164164</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295292.1">
        <property type="nucleotide sequence ID" value="XM_018434961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UP04"/>
    <dbReference type="FunCoup" id="A0A162UP04">
        <property type="interactions" value="705"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UP04"/>
    <dbReference type="GeneID" id="28995867"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164164"/>
    <dbReference type="InParanoid" id="A0A162UP04"/>
    <dbReference type="OrthoDB" id="360390at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008669">
        <property type="entry name" value="LSM_interact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204">
        <property type="entry name" value="PRE-MRNA PROCESSING PROTEIN PRP39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204:SF25">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05391">
        <property type="entry name" value="Lsm_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="9">
        <location>
            <begin position="97"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="LSM-interacting" evidence="8">
        <location>
            <begin position="766"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="615"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="715"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="618"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="634"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="728"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD77252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="786" mass="90245" checksum="FFE2C310BA80C157" modified="2016-07-06" version="1">MASPKDITAHGNAAVDQTIYSVPAKDSGDNDMAINEQSLTDATTMDLTGIVNKNPTYSMEVNESSDDDLLDNQISELDDPAAIQAQKTLEALEQLPQVMEQLDQDNTRFELHVRLIEILSLLDFPDQLESARENMHELFPLPESMWLDWINDAKKNLDTEDGEAKLRLLYNEAEKDYLSIPIWKSYVDFILARFDSVWGDDETGLNNEAEAEMVIENTREDLMKAVRATSYHVMESHEIWNKYSGFEIRVLKRFQSPERFEKVKKAFMERLSTLHIACEQTFSDYSGLISTFDNENYESNMVEANKIYAKTKEAAIERDYFEQQLTQHGYSLDMFYQYIENEKITTKKPSLNNVRGLYERAVSMYCTDVGLWNDYVLFFFERVRVQIFLEATTLRAVRNCPWSGILWAHLGRVLETGKKSHEKISEIFDRALENKALLASLEDLVALLRAKCDFERRRVDWEEPDEETIMDLRVAFEEALVYISEADRGYTAFGKIGDPYYRIEKYYAYIEGKKLGNVKKAREIWEGVIKKHGRQSEAWIQYIDFERSAGNEHRCASLFKQALSKNLDYPERIMDAWMTFEHEEGTVDSMEDALIRINKGSKLLTRNWQANLAEQETAEGKKKEKEKEKEMSAKIKKSAHRRKLKETKKQSFELSMAPSEKENKVHSVPTVPILKRKASEMNIFENDVFKKPKPIQKISAEPKVEKKAVANVETKPASGLGMIPHGMRNARGRGRGKGTRLAISRNQAKPAEQATSTHAPTAGPTAPQTITPKSNDDFRALLLGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UPD8</accession>
    <name>A0A162UPD8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein JTB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_185856</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294843.1">
        <property type="nucleotide sequence ID" value="XM_018439159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UPD8"/>
    <dbReference type="STRING" id="763407.A0A162UPD8"/>
    <dbReference type="GeneID" id="29000065"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_185856"/>
    <dbReference type="InParanoid" id="A0A162UPD8"/>
    <dbReference type="OrthoDB" id="2245086at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008657">
        <property type="entry name" value="JTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13041">
        <property type="entry name" value="JTB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13041:SF3">
        <property type="entry name" value="PROTEIN JTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05439">
        <property type="entry name" value="JTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007840183" description="Protein JTB" evidence="3">
        <location>
            <begin position="24"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD76803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="19742" checksum="47F3D68C396EFB66" modified="2016-07-06" version="1">MQSNNSRLLIIFLITLFLVPSHAFERRAPPPEEHGSSTQNLGDYTHSHEDVKTPTYSCISTGDCDVCTSLEKKTIPYCAEFGNKEPVRCEWNDPDLADRKNQTTFYDYDAISLPSFRSCPRVKRIVRWQLIQFESINLVVAVVSIILVIWRQRKLAREQYLRLAHRIGVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UXW7</accession>
    <name>A0A162UXW7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_185313</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296743.1">
        <property type="nucleotide sequence ID" value="XM_018439058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UXW7"/>
    <dbReference type="FunCoup" id="A0A162UXW7">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UXW7"/>
    <dbReference type="GeneID" id="28999964"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_185313"/>
    <dbReference type="InParanoid" id="A0A162UXW7"/>
    <dbReference type="OrthoDB" id="28455at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="153"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD78703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="230" mass="26401" checksum="548E4D031A0762C4" modified="2016-07-06" version="1">MDVTEVLAAHQAQFKPITVDKLVPLEFDLNLLAGFDSNPIDENRLTSEKNKYLTELIRDNTQLLINEIFKLPVKSTDMGIVAELPARTTPLPREKALPKEKAMTRWEKFAKIKGIQNTKRERMVWDDDRQEYKARYGYSGGAKDGNEDWLMEVPDNTDPMADQYEKKREEKKARTDKNAKRQKRNQEEAAVAPLVSGQGLMSKSSIPVKEFKQKSKNAVPKKLSKKPIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V617</accession>
    <name>A0A162V617_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GATA-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_163254</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298272.1">
        <property type="nucleotide sequence ID" value="XM_018434763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V617"/>
    <dbReference type="STRING" id="763407.A0A162V617"/>
    <dbReference type="GeneID" id="28995669"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_163254"/>
    <dbReference type="InParanoid" id="A0A162V617"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172:SF24">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172">
        <property type="entry name" value="OS01G0976800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="110"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="164"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD80232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="214" mass="23742" checksum="0D6942C0A08E4B52" modified="2016-07-06" version="1">MCDKEEMNSPDQMSIIPDFNGSSSCNSQQTMFNVGGSYSYLSSYSPIDYNYPPDTPVSVSSVPWWANDQSYFEKQQPQSLGYTQEQPKPFSKTPCNETGKSKKKGNGRIKDIKRKCTNCGAKNTPSWRRGLNNSNLLCNACGLYERVNGKKRKVMLQPDGSIKVARGEDSEHSKCTRCAPRSNESKGRLKPTSVASIVESTKSVTLGPSWEKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V6D4</accession>
    <name>A0A162V6D4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_160972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298363.1">
        <property type="nucleotide sequence ID" value="XM_018434325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V6D4"/>
    <dbReference type="STRING" id="763407.A0A162V6D4"/>
    <dbReference type="GeneID" id="28995231"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160972"/>
    <dbReference type="InParanoid" id="A0A162V6D4"/>
    <dbReference type="OrthoDB" id="2289277at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="471"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD80323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="581" mass="67151" checksum="6EFB4411D34B36F3" modified="2016-07-06" version="1">MPMYKNETEEFVFEAEEEYQLWLTNNSACHANWVVQNSNKSKRKVPVGALINPNLIKVTQYIKCDYSGTKAKSSKKQAVENDELPVVKHRNTTGNSIKVGCLAALVVKFLNGGKINEHFEKNLDWKAIKGLLRLEDVKLEEMENSMSMTSIPSAMMIQYKNVHNAIVARITNSTRKHYKDEIKKGYQTMFDTYNSVGPLLFLENAEEWYLDSTHKTCKSFLDNKDCYLMSVAIYNPVTNKGVPVAFFVISIECSYTIARWLNWLKDTNSLKVKQIMIDCSPIEQKAIRDTFGPSVTISNAHLETKNVRANICAALNLIMHSNNEADYNAHWQKFRLDYGMQFPVLMSYMEVTWEPKKKSWDAVCHTNNLIESYHTQLKSFYLGWSHDCRIDRIIYILSQLAERDYRQDTLETYFGIKSIRLSVADTEQKRKASVIAIERANGLVEEVEPQELQAYKMYSCKSFGERCELVYFIKFTTHLHDCSCPDSARLCKHIFLVSRVFDLPVTVRRNVVLDSAVLFGLDNIALLENQMSKDEQKANLLLMNESLERIWKQVYTSSKTFEQKEVLLDLMKKTSNFYSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V784</accession>
    <name>A0A162V784_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_138071</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298552.1">
        <property type="nucleotide sequence ID" value="XM_018429928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V784"/>
    <dbReference type="FunCoup" id="A0A162V784">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="GeneID" id="28990834"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138071"/>
    <dbReference type="InParanoid" id="A0A162V784"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF1">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="480"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD80512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="782" mass="90055" checksum="B749471AB6D65A02" modified="2016-07-06" version="1">MEINTTVGSNSLRETIRFAINPDTLPKGTVASRLSLDRPHLSIQIEHDTHPEPTPLQNYGPRRSSPLKDSLIDTFHLFPKGKLNEEINMKTIDLDENIKEDLLTDDNENENNNDDDDFDWNDDPDQGKVEVQKSTRERIQEAMARRCCWHYLSPLIRRIILALSGSCMFAAIGVCIYLFLPYPTEEEKQDPSFRNVRSNVQCWMYWAAFMWHIGWVTTIVIELLPTVVSTWTKIFKGRRSESVKTYMEYYMSLKWYTGLLTMVSWNWGTWAFLLQYPFPSVHKQDYSRIIWNVYACVFVATCFLFIQKLIIQMIATSFHSFAFNDRVQESKNALKILDSLSRAEARRARQDFANRLRIRRPLSSRISFAPDDSTPTLNNLTAYSATSVGYGHKSDTKRLSNTPEILSQFQKRLQSIVLTDQPQSRTLIDNDKIDINSIEFAKKVARKLFQSLAYPVGTPLSGEEDSKRSLDVSDFRPFFDTFEEAKSAFAVFDRDGNGDLTRREFRDTVVQIYRERKALAQSMRDTSQALGKIDAMLLLISIIATVFVSLAVFNVEVWHSLVPLGSFLLALTFVFGNTAKNTFESILFLFVTHPYDAGDLVIIDEQFLMVHNLGLMGTVFIRGDGQRIYAPTTVLMTKLITNVRRSGNMGETIQINIDFRTPTELIYKLRDQVSEWVSGETRDFAGFDLRVLDIVDVNQILINLWLPYKGNWQELSKRWQRRTRFMLALKGILTDLNIRYELPTQKFTQAQEDRTFLNVKSPLSGNNSVIETPQSFAHLPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V9F3</accession>
    <name>A0A162V9F3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_120768</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-actinin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299032.1">
        <property type="nucleotide sequence ID" value="XM_018428759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V9F3"/>
    <dbReference type="FunCoup" id="A0A162V9F3">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162V9F3"/>
    <dbReference type="GeneID" id="28989665"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_120768"/>
    <dbReference type="InParanoid" id="A0A162V9F3"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000030">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000077">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="7"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="121"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="481"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD80992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="615" mass="70902" checksum="AB8D5D310A08442E" modified="2016-07-06" version="1">MNNAWEAIQQKTFTKWVNNKLDIRQVPHIKELCADLATGVRLIQLLEIIGNAPIPRYNKNPRMRIQCVENVNMALEFIRRIVPLTNIGAEDIVDKNLKLVLGMLWTIILRFTIDDINQEGKNAKEGLLLWCQRKTAPYDQVDVRDFTYSWTDGLAFCALIHCHRPDLLDFSSLDPNDRHGNTALAFDIAEEYLGIPKLLDVEDVCDISKPDERSVMTYVAEYFHAFSTSDKVGTAGRRISKFAEVMSSIWQMQHTYEQRVLALMDAVDNAQQQWKDTVLNDSYDDMKQRVADFSHYKNTQKREWISEKRDLDLLLGNIQTKLKTYNLKPYFPPDGLTLKDLDNIWYSLLQDEALYHQSLNSRIRRIKENLRKAYANAANDFQNQLDTISAELASLDGDLESQLNRLNLTKRKVDPLQLYLHNIEGLDQECIHANTEENDYTVYSVEDLAFGLGLVQQAIQKKNAFIQNQVVSRNMTSLTPAQLEQFEQTFRHFDSNYNNTLSPAEFNASLASLGIFFKDSEFISMFRAVAEGRDEITFEQFIRFIVSVTEDKSTPQQLHDSFRAIAADKPYVTELDLSMCLVPAPFIDYLKHTMPQSREEPGALDYSSYVMQTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162VB24</accession>
    <name>A0A162VB24_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_162016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299443.1">
        <property type="nucleotide sequence ID" value="XM_018434545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162VB24"/>
    <dbReference type="GeneID" id="28995451"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162016"/>
    <dbReference type="InParanoid" id="A0A162VB24"/>
    <dbReference type="OrthoDB" id="2243238at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="41"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD81403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="649" mass="77772" checksum="E6D1134C0666409B" modified="2016-07-06" version="1">MFVLYTQMSWLSYMLPSNHRKTLMRNFKEVMFLICKYSLYVTMIAALPLEILIHLATYVEKEDRLNCALVCNQWTEPFLDAYWARIDIDNNTLQKMFNKFSQTIKELAMSNIDMKYYRHIPILQQKYSRIKYFFWGEFLIDDSVKTKLDWSLWETLSHLEIQFYRKELVLETIFEQLSVLTCLVHLEISRAHSSEENFSTYLTDFESLHRHLPRLEYIDIHTFIKPIHEREIEMIRRVEPAHSIRTVIFSSDAIDTLWIFYFAHKYPNLLSFDLAYHAPPRSLIPRSCEDPQYQSRLQILLSLKQFFPCLQITKTITRNNEFWLHRIFHDALQHFNVKIKYPKITYFGETLEENDISDWIKYFSESAIFLHVSSIFAVRAEAKLLVPCHKLTVLYINYTTMLDMENILDNCPVLQSLYICYSYICSPEYPQPTHLPHSLQKLDIKHTKMNSHTFKYISFRCEQLKYMKLEDIRLYHSDSEETGQLLVDMPFSQLKILSTSDITFFFENNFLYAYKCVKHFVIEQLKNVSINRLDQSNQERTPLSNWYHVCIDETNGKERIFAWELGKRDIEFAQRYYKDFRRRSQQDKERNDMEEFGKGYKIKRFWKRDLKDCVLIFRFKSVEDCSIEESSIFKHVHSRLGSGSGSGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162W756</accession>
    <name>A0A162W756_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_153808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441020">
        <property type="protein sequence ID" value="OAD65085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283125.1">
        <property type="nucleotide sequence ID" value="XM_018433264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162W756"/>
    <dbReference type="GeneID" id="28994170"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153808"/>
    <dbReference type="InParanoid" id="A0A162W756"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="53" mass="6194" checksum="EAD830E917A5CD26" modified="2016-07-06" version="1" fragment="single">PPIALFQDLVYPPTTTLTSPHHHQSNTWLMRMTLSYFPSHLLTLALYTDIWIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162W989</accession>
    <name>A0A162W989_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CP-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_120073</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441010">
        <property type="protein sequence ID" value="OAD65535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283575.1">
        <property type="nucleotide sequence ID" value="XM_018428723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162W989"/>
    <dbReference type="FunCoup" id="A0A162W989">
        <property type="interactions" value="402"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162W989"/>
    <dbReference type="GeneID" id="28989629"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_120073"/>
    <dbReference type="InParanoid" id="A0A162W989"/>
    <dbReference type="OrthoDB" id="10266128at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04178">
        <property type="entry name" value="Nucleostemin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000002">
        <property type="entry name" value="Guanine nucleotide-binding protein-like 3 (nucleolar)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000493">
        <property type="entry name" value="Guanine nucleotide-binding protein-like 3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="42"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD65535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="350" mass="38850" checksum="1248AA4437AC20EC" modified="2016-07-06" version="1">MVRNAESRSTAFDEQEPILEVDKTQQDAAATGHKDNSRKAYYREFRKVLENADVVLEILDARDPIGTRTLQVERMIMDSGVSKRVILVLNKIDLVPKENVDKWLKYLRNEYPTIAFKASTQNQRRNLGHSSVATDAATEDLLKSSECLGADMLVSLLKNYCRSVNMKTSITVGIIGYPNVGKSSVINSLKRSKVCGVGSTPGFTKVAQQITLDKNIKLLDCPGIVFAQQGQDGRTDAEIALRNCIKVELLEDPITPVEVIVARCPTEQLMTMYDVPYFESANEFLISLAQKWGKLRKGGIPDTHLVARTVLNDWNGGKIKFWTEPPAADKSHIGASVVTSWGEALDMNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WCR5</accession>
    <name>A0A162WCR5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_160645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441004">
        <property type="protein sequence ID" value="OAD66305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284345.1">
        <property type="nucleotide sequence ID" value="XM_018434220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WCR5"/>
    <dbReference type="GeneID" id="28995126"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160645"/>
    <dbReference type="InParanoid" id="A0A162WCR5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="139" mass="15846" checksum="F458577BB0F0A28D" modified="2016-07-06" version="1">MPHMTPFTNPPQSDDPGYQPFPQVAGNDHYRPEQHYHGQFNDPYSTLPGPSFPVAMPAPHIPSNDSSPHRSPYMAADRPVFPNHNNPQPQSYNSLNTYMDGSEHVSAVARPPPDWKYSSSPQPQPQQPYQQYQPYQQYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WF69</accession>
    <name>A0A162WF69_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_73545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441001">
        <property type="protein sequence ID" value="OAD66735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284775.1">
        <property type="nucleotide sequence ID" value="XM_018442873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WF69"/>
    <dbReference type="STRING" id="763407.A0A162WF69"/>
    <dbReference type="GeneID" id="29003779"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73545"/>
    <dbReference type="InParanoid" id="A0A162WF69"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF283">
        <property type="entry name" value="RETINOL DEHYDROGENASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD66735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="311" mass="34399" checksum="EFFDE29ADA898578" modified="2016-07-06" version="1">MSSKVILITGGTSGLGLAAARECLTKGHTVVITGRNEASLKKASKQILKNLDLTNKLYTILLDLNNLQSVREAAEQFKALKLPLNVLINNAGLTTPTLEFSSDCERVEKTIFVNAISPLYFTHLLFPLFDKTSRGRIIWISSSLHDPKISGGRVSALSAMPETVDFDNLDGHIVWDSMLFYKLSKLGNVWISNILNEQLLLSEDNNNVSTIAICPGFVPTTALSRNSPWILQMGLRYVLSLMSFTTSEAQAAADYEYYATTPDLEAVSGKFLKKRELSEGSEESKDLTKAKRFWDLACEITGIPKNAKWTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WIE6</accession>
    <name>A0A162WIE6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_63665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285375.1">
        <property type="nucleotide sequence ID" value="XM_018441154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WIE6"/>
    <dbReference type="GeneID" id="29002060"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63665"/>
    <dbReference type="InParanoid" id="A0A162WIE6"/>
    <dbReference type="OrthoDB" id="2288096at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="977" mass="110820" checksum="C75C00DEC0554311" modified="2016-07-06" version="1">MNIQFLFEKGKGSVVDEYGSPEPIDYIVDEEQFRLETLSSHTQYLSQLPLESEKRIDTMQVEKEAKPNGDFTMRETSVKRNYTHYSDQDKVRFFKLLSERCLSAASAATQLGIHVHEVMKKLKQIFTELKVSKTTLFDFVRQHCNLSLKKARLQPKDRKSEEKIQERLDWIRKRKGTPAVVTVTKTRATTTTILGTISAEGLIKCSLRLPQPPSNKKRKRGDGIECVNKGTAQCSNAKAVPGARSFFHLSFAKANASCEFQIGLFANNGIWPSLAFFYWHRICLTQMYELVRVAHKTGQNRVIECAPELSFSDCIVIVRGSIGQLLQSKKKQKVLSTTIPNDAQWCLDHADHLSFKSFIETFDFLDRHRAQQRYTSIVSKYFNSNSERDMTINANYKTWTNSADYLQFWADLAGAELIESALNRRLAISSCSANENIHPTMMETNSVHQTKATALADSDEAVIITHDAQDDSNTNAIKLVINDDVITLHENTGSCKSGSPLTFKSTNVTQLFRSYQVIIRGIILKHQTLPIESYIHELAAHTHTLILCKNQHSPIAERVFSKSLLIALTTNLVSELVDFDLPFPEEDLFTLTTTLFSLALGTTTREQIMLDLYIMSSKIEYRPKRIKLPNTPSNNHDAITETELWSTYYDPVLSCLVGDPDKLVHLRKINSVPIEKGKARPDAVISEKPYLEFTTSIGFGEAKVKKRSGTRYSLCIATLRLITFCKNAIDVNKLDGAIALQIHGMHTTFFLMRSVATGLYTFVEIAHLQFADSVEKLPSFCTLMNVKKLLAVNNVFWRYCKESAQPKKIEARVIPSLGADTYIHTKYLLEILACYEKLVSFRIDFRAALRRVPESLVISLCMSNIPSLEGFASYDSEHHKSILSEETESHLIILMFFFVLFRNNLQMWCFILIDINISCEKYIIMSAINQNIDFKLMVDGGGSLRPSFFYFLLNEEHDTVFTFQGGASCNTGSYTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WJC6</accession>
    <name>A0A162WJC6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_136854</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285565.1">
        <property type="nucleotide sequence ID" value="XM_018429816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WJC6"/>
    <dbReference type="FunCoup" id="A0A162WJC6">
        <property type="interactions" value="1158"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162WJC6"/>
    <dbReference type="GeneID" id="28990722"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_136854"/>
    <dbReference type="InParanoid" id="A0A162WJC6"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD67525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="215" mass="24366" checksum="ABBA5029AB81B533" modified="2016-07-06" version="1">MAEQSEIPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLLFHTNYGSIIFNTWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLCGNKVDIKERKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLVANSNLDFVAAPALAPAEVQVDATLMAQYQNEMEEAAAQPLPEEDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WM05</accession>
    <name>A0A162WM05_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_67064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287005.1">
        <property type="nucleotide sequence ID" value="XM_018441733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WM05"/>
    <dbReference type="GeneID" id="29002639"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_67064"/>
    <dbReference type="InParanoid" id="A0A162WM05"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="182" mass="21626" checksum="0456A243086F2D67" modified="2016-07-06" version="1">MTLLRKNKGYEEQDQLCCYTILLIPLQRLVYEHHFFNQVNLLLCKLISSMSVYHTDIQILRRISICTYENYNWSLSLEMWLLRNKNNRIKDNPTLEALILDNNSTNTQLRIHRQYSFYKSIMWISDLQLKKRVSFVNARHYRPCCSGNNPGTNFCTHTKGRPIKSILCIKNKCSWVQKLGFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XG93</accession>
    <name>A0A162XG93_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="12">COR3 or QCR6 subunit of the Cyt C reductase complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">QCR6</name>
        <name evidence="12" type="ORF">PHYBLDRAFT_76609</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292725.1">
        <property type="nucleotide sequence ID" value="XM_018443175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XG93"/>
    <dbReference type="STRING" id="763407.A0A162XG93"/>
    <dbReference type="GeneID" id="29004081"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_76609"/>
    <dbReference type="InParanoid" id="A0A162XG93"/>
    <dbReference type="OrthoDB" id="405848at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.20:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003422">
        <property type="entry name" value="Cyt_b-c1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="11">
        <location>
            <begin position="46"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD74685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="105" mass="11972" checksum="7148FA77C8DF23B5" modified="2016-07-06" version="1">MGLSDFLSSLMPTVYAEEVEEVVEEVEAEPVEVVEEEEEEEEEPEDPKEAIMEECAQECSSLKKHLDECNERVENGSHENCIEEFFHFMHCADECAAPKIFAATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XJM8</accession>
    <name>A0A162XJM8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_64261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293375.1">
        <property type="nucleotide sequence ID" value="XM_018441264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XJM8"/>
    <dbReference type="GeneID" id="29002170"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64261"/>
    <dbReference type="InParanoid" id="A0A162XJM8"/>
    <dbReference type="OrthoDB" id="10686460at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="540" mass="60281" checksum="20EAFCFDB0E65922" modified="2016-07-06" version="1">MPEGTSLAGAQYFPVECLIVATTTEQACPFRQREQHGVGVLIGKPDSSRLLEPPRSQYFYQLARDESGPTCSTNLPFSTTHLNTRTHGQHHVPILHQQAGWMKSFSPHVSSNQDMALMLTPRTTTNSTTHCREREHHSRLRIQANIHEAPMETLPLGLLMDSIPLGTSFSRLVRRPDHSPPARIRVMDARSKARRHRHILRPLVQLAKLLPKPTVEPTEQVPTQNMAGRLDRNHHSTNLAERTLVPDATRNEHCPTNTSISNGYCPGLPQDTLTLEEPTVEARRIQSLKRRYEDRGLTDDSMNIFMGGSGEQTNQPSVSKGTTPLHYMGIAAGCLPDRILSARPHQLSRYSFGTITSHRTAVLKLHDHPNSIRHHEDITNLFTRLAQLVPPIRKTKPKVDLTLTLQFLSHVASSTDTPLASLSKKTAFPLVMAAFLQPSGNKTILSRKSIYNFILVTHVSTPVLSVVGFGSLVGLLSSFGTWNACDNWSNEDVFQHHYRRNHVLSADFTSLVIRLTNTEDNSVGDKDGEQFFDAPDTVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y1E1</accession>
    <name>A0A162Y1E1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_164735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295885.1">
        <property type="nucleotide sequence ID" value="XM_018435069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y1E1"/>
    <dbReference type="GeneID" id="28995975"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164735"/>
    <dbReference type="InParanoid" id="A0A162Y1E1"/>
    <dbReference type="OrthoDB" id="2237019at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="323" mass="38021" checksum="161E0C0C5640A36A" modified="2016-07-06" version="1">MVTLLILLSAPENVYKCLEYILNQYEGKHELNYAFDIRRLPIPRLFSILLNHLMHWRSVVYSVNSLSAFVKNPLPKGYDNDLQLFYEVFNFKLLEYSSIEGLMFNGENNVLLGIIDRSDGFSVDFLFYKRSHNTTDEISIVDHDFGIKHFIFEEVTKMYRPSFLDPGRNRVFTAAVRLDPNDHQLRRCTTKEYFHLTGSTVMDTVFTFYGFNTVPWLADILEPKFYVNKVEYVLEQKSKQTNAVTATVSAISWPNSLTLLYRRQKFKSRVAHLYCVLFVQVIRENIPSFLGSSFYVYGLPTMIRKFYKKTWGVYRDLKLPRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y3W0</accession>
    <name>A0A162Y3W0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_163289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296205.1">
        <property type="nucleotide sequence ID" value="XM_018434770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y3W0"/>
    <dbReference type="GeneID" id="28995676"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_163289"/>
    <dbReference type="InParanoid" id="A0A162Y3W0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="139" mass="16441" checksum="EFBFCA1C85B76CB7" modified="2016-07-06" version="1">MESNLQLLALSLSFLRAGWILIECALILLVDVRSVYNSSQNALPKLITKHVVPSWSRKQQEINAVNPKYIYYSRSLYIYAHNIIFYTSYIYLQAPDTLSYYLFTKIFCAVRVWWLDVYYFWRTFKNNLENISSLAETSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZCC5</accession>
    <name>A0A162ZCC5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_175784</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441027">
        <property type="protein sequence ID" value="OAD65821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283861.1">
        <property type="nucleotide sequence ID" value="XM_018437575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZCC5"/>
    <dbReference type="STRING" id="763407.A0A162ZCC5"/>
    <dbReference type="GeneID" id="28998481"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175784"/>
    <dbReference type="InParanoid" id="A0A162ZCC5"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46809:SF2">
        <property type="entry name" value="GH21273P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46809">
        <property type="entry name" value="STROMAL CELL-DERIVED FACTOR 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MIR" evidence="3">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="3">
        <location>
            <begin position="87"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD65821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="209" mass="22904" checksum="FEB478C7DDC8DE1F" modified="2016-07-06" version="1">MKLIWLAFIPLAFAASSVPPLEEGFQHVTCGSTIKLSNQANQHRLHSHGVSYGSGSGQQSVTGFSSSDDANSFWLLRAAFGKQCKRGDPVPCGSIIRLRHTNTNGYLHSHNHKSPLSSQQEVSCYDGNDTGDDWRVECASGSKFWLREEPVQFVHVESQAYLSCNGAHQFGHPIPGQLEVSGTKGSSKHTQWIAQEGVYFAAPITEHHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZFY7</accession>
    <name>A0A162ZFY7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_189273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441002">
        <property type="protein sequence ID" value="OAD66521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284561.1">
        <property type="nucleotide sequence ID" value="XM_018439633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZFY7"/>
    <dbReference type="GeneID" id="29000539"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_189273"/>
    <dbReference type="InParanoid" id="A0A162ZFY7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007841460" evidence="2">
        <location>
            <begin position="21"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD66521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="208" mass="22134" checksum="2BCE1C15DC3263AB" modified="2016-07-06" version="1">MHYSLLYLILFLSLVLCVRAGDDEDDYDDDYEDEQVLTVWKTKTKIVDSHTPVYDNGGREDDKVDTVDENDKDSKSGHDIDTEIDKEEDNSTESVSLNEEEVDDVPVASVIAIDEEQEDQLIKNFAAAISEVPASAPAPASASASASASNAINVKQASVISSLTSAQSASRSASSSYSSSSTVSSASGLKISISIAVASMILVVALIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZK08</accession>
    <name>A0A162ZK08_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_63678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285361.1">
        <property type="nucleotide sequence ID" value="XM_018441155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZK08"/>
    <dbReference type="GeneID" id="29002061"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63678"/>
    <dbReference type="InParanoid" id="A0A162ZK08"/>
    <dbReference type="OrthoDB" id="10369362at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD67321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="146" mass="16276" checksum="54347B10AFF78CDC" modified="2016-07-06" version="1">MIKLVLKRWRNLRLATKVHHLFVIVVVLLLIALVILNNRTGRPPAWVLGTVLGACVCLSGLYWLARYIQAKRIPDHQEESFFPIEERMASCSSVAGLFPQSILSMDSLQRAQSITSAPPPAYKTSISIPPSYRSSASSFKPISPHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZLF6</accession>
    <name>A0A162ZLF6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_173943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285651.1">
        <property type="nucleotide sequence ID" value="XM_018437144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZLF6"/>
    <dbReference type="GeneID" id="28998050"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_173943"/>
    <dbReference type="InParanoid" id="A0A162ZLF6"/>
    <dbReference type="OrthoDB" id="411871at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="653" mass="73793" checksum="5160CF5162B63349" modified="2016-07-06" version="1">MGSFLGDHAITSRGTSFLQWIQATGLTCWNELLAFGIPTFLSGGSGTSRSSVIDLFLSTSPLLNPSMQIRSDLSLGSDHKMVNLTFTPYVSPPPPPTNHPRLLWNLSKLAQPDTLKIYIDTASASLDNLTEQFSAFLSSSSPPPVDSLCSAFAQAIYDALDTAVGRRTPRTMQKYWFWSVDLQQAMDLRERSYQRWRHSSGLQKAICWMRHQDACHAVRLSVQRRRRETWKEFCNKLATQDFAKTTATMKRIKSHRQTSPVFVDPGGPQVAANKMADHLQQIFSGQFLPARRPPDQTVMISSPIAIDESCPFTHLSVESAILKLPTRKAPGVDHLRAEMLHPIVKQVSPVLCLFMRALQLLGVNHTGLSRLLSIHLYCQFIHPQFEYGLAISCFNIKQVAVLEKAQNTCLHMIFGGHSTSSTSVFRRLGNLLSMRERILTLGFKFVYRAFWLPDEALFTLLRPVLTNPAHQWFKLLANPIWLSLSNRQNADSKACKHAIHSFLNQGLSLKRSQQILLSACRPSLGVDPILWLPMTNYECSRFIRWRMGWLPGRPQPCSCGLHTTSRHHVIECTGAAICLHLYSTVQPNPIDYVLNMLPMKKLKNNKNNAFWIFTWPILCRIILDIEQICLPGVDLADHAATDRGQLFLNWLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZNG5</accession>
    <name>A0A162ZNG5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_86371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286071.1">
        <property type="nucleotide sequence ID" value="XM_018443646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZNG5"/>
    <dbReference type="STRING" id="763407.A0A162ZNG5"/>
    <dbReference type="GeneID" id="29004551"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_86371"/>
    <dbReference type="InParanoid" id="A0A162ZNG5"/>
    <dbReference type="OrthoDB" id="4217619at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06719">
        <property type="entry name" value="PDZ2-4_Nma111p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025926">
        <property type="entry name" value="PDZ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46366:SF1">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN C1685.05"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46366">
        <property type="entry name" value="PRO-APOPTOTIC SERINE PROTEASE NMA111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12812">
        <property type="entry name" value="PDZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="220"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD68031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="910" mass="100610" checksum="0E99CD5C97B97AEE" modified="2016-07-06" version="1" fragment="single">QETWETTLEKCIKSIISIKATRVRCLDTETPGAFTATGFVVDPVRGIILSNRHVVSVSPIVAQAVLCNYEEIELVPIYRDPVHDFGFLKYDPTHVRFLTIPGIPLCPEGARVGQEIRVVGNDAGEKLSILAGTLARLDRETPNYGIGEYNDFDTFYMQAASSTSAGSSGSPVLDVYGRAIALNAGGATNSSSSYYLPLNRVKRALECIQNSQHVSRGTIQAEFEYRSYDELSQLGLSLHIEARLRLYNQESIQGLLVVKSVLPLGPADGHLASGDILLTGNGRIVTHFLDLADLLDNSVHNTIELVVSRGQGVLHQVKVTVQDLHAITPNRFIEFGGGILNDLSYQMARSYGLSLDKPGVYVAAAGYILGTALALRKSVIIGLNNQVVRNLDDFIKISKEIPQGERVPIRYYSLSRALKDKVMILHVDHTWHKFRMAIRNDTTGLWDYKNLGEPPIITPLLKVPRRLFSVKTDPFQRLAKSLVAVDAHPPYIIDGLKNSHSYGAGLIVSMDPPLVVCDRDTIPVGISAISLTFGNAITMSARLLFLHPFYNYAVLTFDWDRLESSGIEVHVAMFSDKVLKPGDRVNYVGLGGDNLPVIKKATVSMLKPIRTKETSPPRWRAMNVEAYKTSEGSLNGQGGVLADEDGKVQASWMSFSNEDERGNQGGEMGGLSAHLILPILDAIRAGEVPGVRGLDAELWTMQLANARLLGLPEHWLDRYQETENQSHVLYITGITDASSPCAGLLSAGDIVLLINGVMMMNVSDLARFSQEEELKMTIFRNGHELEIVVPTTYFNGQETTRVIGWQGMLVQDAYMAAKEQMQKEVPKGLYVSCCLFGSPAQMSLRPGIWITEINQRPVHTLDEFFDAVKLGNQKAESHVHVKYVSRNNGTHLVALRLDHHYWPTWQIQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZP49</accession>
    <name>A0A162ZP49_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_188836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286211.1">
        <property type="nucleotide sequence ID" value="XM_018439569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZP49"/>
    <dbReference type="FunCoup" id="A0A162ZP49">
        <property type="interactions" value="361"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162ZP49"/>
    <dbReference type="GeneID" id="29000475"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_188836"/>
    <dbReference type="InParanoid" id="A0A162ZP49"/>
    <dbReference type="OrthoDB" id="2228at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="686"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="686"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="713"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD68171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="723" mass="81424" checksum="32F21FF62845A433" modified="2016-07-06" version="1">MASLIDIMRKRLLDTIRSIQPPGKWKIVVVDSRSYQILSAACNIDDILEMNVMTVENIEKSRTHYATNEAIYFLTPCQESILRLVDDFRDHRNPQYKAAHVHFTSGLDDMMFRDLNQRLKSTGASEYILCLKEMYVDFMVVESAVFTVEPVTSFFSIFGTDPRSHPEDSIRVTAKQLLSVCATLGEDPIIRYQTPPPPPPPSQSPTDGLLPQQGSATRSLATILQKEMDDFCRISPNFPPARNPPQPRATLLILDRSIDPMAPLLHEFTYQAMINDLLPVEPSESKNGIKYTHEYNQEDGTMATMDVILNEEDAVYRSVRHQHIAECTENLVRDFKKFLEDHKATSQAGDRQDAPRDTTKNLKDMKEMITNIPKFQDMKAKYSAHISIAQECMSRFEQQKLNSVGNLEQNMATGETPSGNTPKTIVLDMVPLLDDPHVSPVDKARLLMLYILYKDGNLYDDDKRKLLEHARLPIDLREAVNNLSLLGIKVSRDRKLKEKGRKKEKRRRDSRDAPFELSRYIPNVKRIMDSQLSNTLEASQFAYTRQSDIEHTEEANGAPHSAIPASGISLRTTKPTWNKKGGNGAGQPFGASRAKLIVVVLGGMTHSEIRSAYELAELHDRDIYVGTTEILKPSKFVENLSRLRQPIPAARPIIAPYVAPPPVQEPHKIPKISNLIPHINHTTSSLSSVSLNSPSIKSGTSGQSTPDKPEEKKKKRGLKKLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZYR5</accession>
    <name>A0A162ZYR5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_188186</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287941.1">
        <property type="nucleotide sequence ID" value="XM_018439462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZYR5"/>
    <dbReference type="STRING" id="763407.A0A162ZYR5"/>
    <dbReference type="GeneID" id="29000368"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_188186"/>
    <dbReference type="InParanoid" id="A0A162ZYR5"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000947">
        <property type="entry name" value="serine/threonine-protein kinase OSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047173">
        <property type="entry name" value="STRAD_A/B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014:SF21">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="105"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="416"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="571"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="631"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="753"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="827"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="511"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD69901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="850" mass="93233" checksum="7740819BB4FC01CF" modified="2016-07-06" version="1">MTQKPLNTPQTFAKLSTPTFDQPASPSHRARSSSLMRVVSHHNAPLSNGGRASPTIRRSMSISDGQQRSTFYHHDPSSEISQATSSTPTLAQVSETNWANRIEDFDMKHPIGYGSSAVVYEAVYKPLNKRVAIKILDLDMFERNQIDELRASAQGTSFEETALMALSKHPNVLRVYGSFVSGSKLYIVTPYLSAGSCLDIMKTSFPDGFEETTIATILKQALEGLAYIHKNGHIHRDVKCGNLLMDEQGTVMLADFGVSSSLSENGDKRKTFVGTPCWMAPEVMEQSTSGYDYKADIWSFGITCIELATGHAPFAKYPPLKVLMMTINKDPPTLNRDTTRHKYSKGFKEMIDSCLQKDPTKRPSAEKLLQHPFFKQAKKKDHLIKAVLAHVSPLEQRPHKKMPLKQISFQTTEQWDFDTQSDSEGAQSDKSQLSVDAPPPARKHITFGDVVIRDPVPRASHGPVVESPPYSPQTTISSQTPKKSRFVVDDGREDSSSSAASVPTAVGPTPSLITTPILSSTPSGSDAAYPGTGSDVGSPTTIESPSVGLGIMAHQTPQEGEVRKGRFSVNQTPRSMSEDSNDAPHKSTSPPPQEKSTPQVRFETFPISRESSHSSVLSLSRESLNGKVSRFSVEKEQGKDSASLPHPQIETSVPQPIPPECRKKGRFELTGGQSAPLTPIETSRIDREVCGDSSQSSLIGSPSTSPCNSLLRGQSTLLDAAKADLMKARMEELLRYTETQRVLLHDAIQTLNSTPSHPALPSLPTSYPPSTPTSILVSRSRASSDTRKSANNDPLELSEFQNNKSSSLSHEISSTVEHLQHLLLISNKEKEKLTKENDALRKEIERLRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163A6Y6</accession>
    <name>A0A163A6Y6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exocyst complex component Sec3 PIP2-binding N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_187571</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289531.1">
        <property type="nucleotide sequence ID" value="XM_018439395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163A6Y6"/>
    <dbReference type="STRING" id="763407.A0A163A6Y6"/>
    <dbReference type="GeneID" id="29000301"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_187571"/>
    <dbReference type="InParanoid" id="A0A163A6Y6"/>
    <dbReference type="OrthoDB" id="27109at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01313">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="6">
        <location>
            <begin position="50"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD71491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1069" mass="122584" checksum="26E2E0E36CCF5B35" modified="2016-07-06" version="1">MATDAIRQAIIASLFSSDTGGGAERLLIHVKVFEDVKQTDGGGNVRSPNIMGKPRYLCLTQKRNKVRLYKTKRNQAGTFSIGKAWSLDDIRQIEVIDANQFAMTLNKQYLWAVEIPRDKMIFLAHVVDACQRFLSRVPKLVNVDEAYLLRFLNNSTSLPVSPTTASPHIQSPSINSDDASANIPYSQHDASFQSLAPPAPYGPLYPVQNSDRNLGMVDSPMAIQSPMLPPPPIILAPPPPPSPSTRIDDSPRILMEAKEREREERKERDRARELRREREKREKAVEEEKAKRKLMADMQDKMAEQASLMNVEELLTDFNWKASGNAAALEKRLLGELHALEAANVHAIIQSDERVRSVVQHIDNALDELDSMESWLLLYSAELNASVNNINSNNKSTLSMGDDIREIESQNRGLQILTSNQHHLITELDELLSAISIPRACLESLKFDPMDTVDDIERIQSSAERLQKVLKIKLDGGLQDMHAVQEKLETYNVHSNTFCSRINDFLKKQFDQQAKILADSRTRSQPTVSVRKPQSIVAQPHESVEDGLIRYQGFSLWEKELEPRMYNELQRYYAQTMAPLYEKDIRELMDATRGFYSTLRNRGLDELEYIFRPEESRPVRALAYGADKLRGGDESRTHRYRHILRGSVEGMNSPGLTAASGGNTRGGLDEEEKLADDAFSQMISQGAMLVGREQNFMSDLFQIAPNAPKSFLERGPVFTQVPSVADLCERREKIRDVKISKKILNWMELLFETLEPSLVSLIEYGVKSDPTQTVSMMSSVEFQQEERKESDQEFMLRLCSSLMQRLKRMFERFITDQIRIIEETKVSSKKRRGILPFFRTFPIFALRLEIAAATIEPESETRKTVNEAYERVINGMMASLDSIARESDQTGDDKEQLNANIMYIENMHHFYHELRTHKLHVLERWIKHAKSQYDSRLNAYIKVIIRRPLGKLLEFFEGVEAMMHTSTPEEVSFHTNYNKIQLRKVIMLYPAKEIKKSLELLYRRVDKHFSEEEGLLQVVWRGIQEEFIRQHEKMEDLIQKCYPDAGVHLEFTIQDLLAMMSELARKVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AX56</accession>
    <name>A0A163AX56_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_5947</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294441.1">
        <property type="nucleotide sequence ID" value="XM_018440500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AX56"/>
    <dbReference type="FunCoup" id="A0A163AX56">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163AX56"/>
    <dbReference type="GeneID" id="29001406"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_5947"/>
    <dbReference type="InParanoid" id="A0A163AX56"/>
    <dbReference type="OrthoDB" id="10262062at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002621">
        <property type="entry name" value="PRK02287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase L inhibitor RLI-like possible metal-binding" evidence="7">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="6">
        <location>
            <begin position="43"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD76401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="20524" checksum="EE9B0ED12A7514F9" modified="2016-07-06" version="1" fragment="single">SSIPMPVAMWDFKHCDPKRCSGVKLSRCNMLKTLKTSQRFRGIVASPVGEKAVSPADRRIVELYGAGVVDCSWARIDEVPFSKIRGPTDRLLPYLVATNPVNYGKPWKLNCAEALAAIFYITGYPEHGEALLAKFKWGHAFKKVNGGLLSRYAKCKDSAEVVQVQNDYLKQLEEDSERKEENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BDA9</accession>
    <name>A0A163BDA9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase family 5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_100304</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298851.1">
        <property type="nucleotide sequence ID" value="XM_018427580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BDA9"/>
    <dbReference type="FunCoup" id="A0A163BDA9">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163BDA9"/>
    <dbReference type="GeneID" id="28988486"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_100304"/>
    <dbReference type="InParanoid" id="A0A163BDA9"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046557">
        <property type="term" value="F:glucan endo-1,6-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF43">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="61"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD80811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="332" mass="37910" checksum="8AE8D002E31CD555" modified="2016-07-06" version="1" fragment="single">VAQVYRYRRQIGVNLGCVFILERWLCPLKLCQQVPAAKGWESEHDFLKSCSSPQEARRILEDHWETYVTQDDMAILASKGINTIRLPIGYWIVQRSLLVPPFASFEGVYDSAWNWFLRTIHMAAQYGIGVLVDLHGAPGGQNSDTHCGVSTGRAEFFTNPHYQEVTLEVLCTLAHTLVKINNVVGLELLNEPTDHPSLEQFYERALTKLSYPDTIGLPLYISDCWNPDGKYTQWLQSRLQLIVMDTHQYFCHTPRDHARSALQHTQDLKTLVRDRVGRARDQLAGCLVVGEWSVVLNHQSIPAHENDANVMRDFGKAELQVWDQVSAGNFYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163D3Z1</accession>
    <name>A0A163D3Z1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_150144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286590.1">
        <property type="nucleotide sequence ID" value="XM_018432413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163D3Z1"/>
    <dbReference type="GeneID" id="28993319"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150144"/>
    <dbReference type="InParanoid" id="A0A163D3Z1"/>
    <dbReference type="OrthoDB" id="2289470at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="301" mass="32838" checksum="B59A8A32F59745CB" modified="2016-07-06" version="1">MANLQIGNMQGLPTELTSFLTTLQAQIMNVQNRTDQLERLAAENARLTTELDHARTTIANLQKQLGSQSASEKNFSEISLSNPAGAVGAPDKNKEPGLEASTWATKASVSLPVTAPKMSTVPSAHRIAASVRMFALPSGPSGYEYVYIPRSRRLKHKEVRSSLRTLGVDSSRLLDINFPARGVIGILVHVQYADTFKAKLTTASVEILDAFDPLDPDNVADPKYASLSTHELANTAAMLHHDRCLQALQFLRPHVAIPVGHFFCEEGWISEDEIPTRTTLTNATGGSLFKRQRSSSVTMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DB88</accession>
    <name>A0A163DB88_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">No apical meristem-associated C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_148686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288170.1">
        <property type="nucleotide sequence ID" value="XM_018432134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DB88"/>
    <dbReference type="GeneID" id="28993040"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148686"/>
    <dbReference type="InParanoid" id="A0A163DB88"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="31397" checksum="6A056BB919DAB61D" modified="2016-07-06" version="1">MSFDEKTGVFKIKRNRVTSSYKLWKVPDGGEDNRTPLERLYHFLFKDEGDNLNKYFDGTPEGETFVTTKTMIIDDCREYFAEQGIDQPAAQIKTRINYLIDKQYLPALNLMRHSEEFPSHYRKLEEICPEFFRINEIRRPGETESPCISNSGTPFDFANEYGLSSASRKKKISGKKRDLTDAQLDEERRKDTEKKLKVVDATTKAWRDEKFALQKAHFFKAREDRLKKEAFEADVKMIFEMASLFSWSEEKVQEEYEKRCNKRNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DFA5</accession>
    <name>A0A163DFA5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_148069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288890.1">
        <property type="nucleotide sequence ID" value="XM_018432003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DFA5"/>
    <dbReference type="STRING" id="763407.A0A163DFA5"/>
    <dbReference type="GeneID" id="28992909"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148069"/>
    <dbReference type="InParanoid" id="A0A163DFA5"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="88"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="312" mass="34844" checksum="379E04735763E0BE" modified="2016-07-06" version="1">MSSSTISFETINGSVTNIKGTDATSALKNKGSTACGRAYHNAETGTYILPCDDDEKKRLNLQHNIFKIMFDGLTVPAVKHNFAPGSKVLDIACGTGIWTMEMAQAYPDCTFIGIDMADVFPKENVPPNVEFKIVNASDLSEFEDNTFGLVHTRLLIAGFPADKWIPMIKEIYRIVAPGGLVQFLEYDFISGPKQGSILKVITSLYFAITERNNDFFIPQKLAPYLLHSGFDVILEDNKKQMFSSEEDNLSKMILQNWIEALDGFKPFMIPHLCPENPEAFDSIIDIYIKDCIEHKWFLNAVIVVGAKPLIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DUM5</accession>
    <name>A0A163DUM5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Proliferation-associated SNF2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PHYBLDRAFT_145900</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291550.1">
        <property type="nucleotide sequence ID" value="XM_018431557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DUM5"/>
    <dbReference type="STRING" id="763407.A0A163DUM5"/>
    <dbReference type="GeneID" id="28992463"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145900"/>
    <dbReference type="InParanoid" id="A0A163DUM5"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006346">
        <property type="term" value="P:DNA methylation-dependent constitutive heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18009">
        <property type="entry name" value="DEXHc_HELLS_SMARCA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000015">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000577">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044753">
        <property type="entry name" value="HELLS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47161">
        <property type="entry name" value="LYMPHOID-SPECIFIC HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47161:SF1">
        <property type="entry name" value="LYMPHOID-SPECIFIC HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="233"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="627"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="176"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="496"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="504"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00053349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OAD73510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="868" mass="99191" checksum="CDB0243638EC5BA4" modified="2016-07-06" version="1">MNLIAVDTERNSSVESDSVSSASPVSTSQTTPAVMSDQEIDIIDDEEKITNEMIKVEEEMSQVTVKEEEQRIEEAAQVQFDTTIKEQRMKRLNFLLEKSGAYATILGRKMAKQQEEAREKAAKIDAANEAKKAGSVQDKPIKEATKPKASAINLRKRKINDEADYQLGEYINEDDVKRRKQTDDNVSKAIQEDSGRGTVPSGQIKPTISARQPALVTGGVLRDYQLAGVEWLTSLWENGLNGILADEMGLGKTLQTISFIAHLKAMNVSGPYLIVTPLSTLANWVNEFKRFTPEIPVLLYHGSKEERQHMINRKMQKKKETLREFPVIVTSYEIIMNDRKHLQRYNWKYIVVDEGHRIKNLNCKLIKELKTYSSANRLLLTGTPLQNNLAELWSLLNFLLPDIFDDLDMFQSWFDFSDINQKSGQDRIMKEEEEDNIVTSLHTILKPFLLRRLKTDVERSLPKKKEYLLYAPLTQPQKDLYDAILKRDLRDYLIKRKTNTNDEPNPKELTEEKSEEETQRSKRQSDRGSKTTSYKEQSDRDFFAQQSKALEKADPESITSESILEAGKKHEMAVATKQVNGMHLQNLVMQLRKVCNHPFLFDWPIDPKTNTYVLNNELAAQSGKVLLLDRLLTALFERGHKVLVFSQMTKMLDILEDWSTGLKNWPVCRLDGSVSQESRRKQIETFNDPESNVKLFLLSTRAGGLGINLTAADTVVIFDSDWNPQMDLQAQDRVHRIGQTKPVLIYRFVTGNTVEGKMLEKATAKRRLEKLVIHKSKFKSPVTGLPLSKKDQANTVRELAEILESQDGEQVQIVSQGDKVISDKDLEMLLDRSEKVFEDTTVRVSDQFKEMNTADMVDQKNEILATRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163E0X5</accession>
    <name>A0A163E0X5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_61323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292660.1">
        <property type="nucleotide sequence ID" value="XM_018440790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163E0X5"/>
    <dbReference type="GeneID" id="29001696"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61323"/>
    <dbReference type="InParanoid" id="A0A163E0X5"/>
    <dbReference type="OrthoDB" id="2285317at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="136" mass="15704" checksum="92E8846044CC4715" modified="2016-07-06" version="1">MSFSKFCQSAKDTFQRKGRKSSKSESCKSVRFQSESGAVFYTHSSEDYDRRSSFSTMLDEQSEPELVAEMLKHAACGDQLSEMTQQDEEAFVLKLDEEVIRNTLVNRKQGYHSIAALYHYYLVYRCVLEVGRVEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163E6V6</accession>
    <name>A0A163E6V6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytidyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_101129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295080.1">
        <property type="nucleotide sequence ID" value="XM_018427625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163E6V6"/>
    <dbReference type="FunCoup" id="A0A163E6V6">
        <property type="interactions" value="266"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163E6V6"/>
    <dbReference type="GeneID" id="28988531"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_101129"/>
    <dbReference type="InParanoid" id="A0A163E6V6"/>
    <dbReference type="OrthoDB" id="5591297at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285:SF0">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD77040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="156" mass="17733" checksum="D6DE935FC6BF139E" modified="2016-07-06" version="1" fragment="single">ILVLDSSFNPPTLAHRALLTESLASFPKDYFDASIVLFSTRNVDKQLTGASVLQRAQMMEIMARQFGDTTNSINTSTKALENIAVALTPHGRFIDKSIHIQTFFKHQFDANVTIKLYFIMGFDTITRFLDPVYYPEGRDTALEPFFRHSHLICADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EMJ4</accession>
    <name>A0A163EMJ4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide lyase family 14 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_162574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297550.1">
        <property type="nucleotide sequence ID" value="XM_018434656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EMJ4"/>
    <dbReference type="STRING" id="763407.A0A163EMJ4"/>
    <dbReference type="GeneID" id="28995562"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162574"/>
    <dbReference type="InParanoid" id="A0A163EMJ4"/>
    <dbReference type="OrthoDB" id="2395160at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048958">
        <property type="entry name" value="Polysacc_lyase_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124:SF1">
        <property type="entry name" value="DISAGGREGATASE RELATED REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21294">
        <property type="entry name" value="Polysacc_lyase_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide lyase 14" evidence="1">
        <location>
            <begin position="77"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="333" mass="37110" checksum="AD0719BDCB1FABDD" modified="2016-07-06" version="1">MRVDIEENCKVRLAFKLGPVSDRTTELGMEQYWIAPMPSQERRSDAAKYIREEWKMPSSYFYGTNDVGFSDDPVTGNTTEPALDILYRNGSFTPSGSMQEGGQEGGCIFYSEPFGDHAFERALLSYDIAFQENFDWVKGGKLPGLFGGEGNNQCSGGSDANGENCFSLRPMWRAKGAGEIYAYVQTSPDFCNSKDTIQCANNYGVSMSRGSIKFTANKWSKLEIYSQMNSPVNETNGVLKVWQDGKVVMNYENINYRSVDSLALTRIYFNTFFGGNSEKFAATSDSHIYFKNLEYSVGKRAVAYEPTVESKSSVVSISWIVFGVSIALGLFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ETG1</accession>
    <name>A0A163ETG1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_139012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299500.1">
        <property type="nucleotide sequence ID" value="XM_018430131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ETG1"/>
    <dbReference type="GeneID" id="28991037"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139012"/>
    <dbReference type="InParanoid" id="A0A163ETG1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD81460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="227" mass="25580" checksum="620C99CE1C420440" modified="2016-07-06" version="1">MYAEQVLAELWVLALAVNHRLHIFESGGSDPLVLKKFLVGRNVFVFHPQDYDRVLGLFFLDVLDIRNPCIWTLFVSVADCFLQAFDCRVFEICLPVFLATVCSNLAAVYPDFALDYNISGLHLSAVLSVALSVVPVAVLVVVLVVVLKNMTTAYIWALPWVWVLTLLTHARILSYGAGRLSFLVVIHPTCSKLVKLDFLEKYYSISWSAFGFYPVDQAESIDRFLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167J4Q9</accession>
    <name>A0A167J4Q9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_176405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441015">
        <property type="protein sequence ID" value="OAD65128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283168.1">
        <property type="nucleotide sequence ID" value="XM_018437757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167J4Q9"/>
    <dbReference type="GeneID" id="28998663"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176405"/>
    <dbReference type="InParanoid" id="A0A167J4Q9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="314" mass="35462" checksum="FDF3D5A95AAA202E" modified="2016-07-06" version="1">MSSNTQQSKKTKKTTIKKSVQQTARTAASTRQREILPSLTVSAELDCTVLSTLSTMSTRLNESHSLLEKVYHNMGATNGQNNNSNYSPIGQALTTGEYIKYRLPTVSNIAKLLTLYFAEIDPFSNTTVLATMSLTVNEGAFSTSNRPIADVVQSYTHQQAEVKSVSSAVVEEKTRRHISYMLQRAKALPEKIARQNRISRRRSKKRNILADYKAIHLADKANLESKFGETVVDLLDYDMLSDIESDEEKNKTRYTPRNRHPLVDEYFTVLKKQRLANKGPDVIGNSVYPIILRNTELSNKKKARVAAWIHTHQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167J4V5</accession>
    <name>A0A167J4V5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_69074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441014">
        <property type="protein sequence ID" value="OAD65147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283187.1">
        <property type="nucleotide sequence ID" value="XM_018442050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167J4V5"/>
    <dbReference type="GeneID" id="29002956"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_69074"/>
    <dbReference type="InParanoid" id="A0A167J4V5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="131" mass="15085" checksum="61E4B8E4C4A4032E" modified="2016-07-06" version="1">MEGLKARKIYAEKVGSGLSQDLKERSESDEELQIILIKYSQEAKSRQRTKEEAEKEVDDLNRKLVKKDDLSSLILSITRLEVSDEENSACIRDRINLIKLFDEEFNLEASTPLEPDEDTSTLTRMFDMNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JCS6</accession>
    <name>A0A167JCS6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_160780</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KV441008">
        <property type="protein sequence ID" value="OAD65736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283776.1">
        <property type="nucleotide sequence ID" value="XM_018434245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JCS6"/>
    <dbReference type="STRING" id="763407.A0A167JCS6"/>
    <dbReference type="GeneID" id="28995151"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160780"/>
    <dbReference type="InParanoid" id="A0A167JCS6"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF169">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD65736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="284" mass="32317" checksum="E00957B4BAE84C95" modified="2016-07-06" version="1">MNSAAYLSGEVDKLVAIPGIPFPQYYEFFMDWKTPIAIASTYALTVSLLNPPPSASKLSRVEAKNRGVQDTSKSSGLMTAFVFLHNLSLSIYSMITFYNMAKGMHRSFNRGQTLHDAYCDKDSFLWNDSLAYWGYIFYLSKFYEVIDTIIILLKGRRSSLLQTYHHSGAMITMWAGIRYQAQPIWIFVVFNSFVHSVMYLYYAMTCVGIHPPGKRYITTMQITQFLVGTTTAVSYFFIPSCLTTPGQHFGVAVNVAYLFPLTYLFVDFARKTYGKRKLAAKKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KKS8</accession>
    <name>A0A167KKS8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_173319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286357.1">
        <property type="nucleotide sequence ID" value="XM_018437002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KKS8"/>
    <dbReference type="STRING" id="763407.A0A167KKS8"/>
    <dbReference type="GeneID" id="28997908"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_173319"/>
    <dbReference type="InParanoid" id="A0A167KKS8"/>
    <dbReference type="OrthoDB" id="10044727at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="296" mass="34167" checksum="53B964E4F8A832B4" modified="2016-07-06" version="1">MPQLSTDEVEHVLVTHDESTFYSNDGKEAMWLVEGENPIRKKSPGMSLMISEFKCISHGTIWEVFHPGANRDGYWTSSHMLKQLESNAIPLFEIIHPGCKVAFVFDQSTNHKAYSQNALIANKITLGDKEVEEDNLCTLKDTTFVWDGEEQIQSMYYKKDEWFTKKSGQWVTKKVKYVKGICTILEKRDASEDSKCCAHHFLTSQPDFISQKTALHEAVEVSDHIFGLYLKFHCKCNWIERYWGTAKREAWLQCDYTYKSLDKKIFILFLIMLESFKTSKDTTTACGAILRHTAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KRA0</accession>
    <name>A0A167KRA0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Partial AB-hydrolase lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_63404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286729.1">
        <property type="nucleotide sequence ID" value="XM_018441116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KRA0"/>
    <dbReference type="STRING" id="763407.A0A167KRA0"/>
    <dbReference type="GeneID" id="29002022"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63404"/>
    <dbReference type="InParanoid" id="A0A167KRA0"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="2">
        <location>
            <begin position="147"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD68689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="543" mass="61434" checksum="B8DE1B6F565F494F" modified="2016-07-06" version="1">MPPDPLFISLGAASSTDRLIDTVDKRTPITTDSGMWTTNIGSKDKPSNQKLLPSSPLSTSPLAPSSPYSYSYSSLNDKRIKRSATERLAIMSRTALSLALSCPLLLVLLTISLYKTIHRAYFVESAIDDDEPEENQPKEDIIPDEIYYASRWGYDSTLHQVVTKDGYILSMYRVSKKGVNPIDKPPVLVVHGLFQCSGAFVLNEEQSLAFALVDQGYDVWLGNNRSTGGLDHVSMSHKDPEYWNWGLKELGIYDCVGMVNYVRQTTGQPKVGYIGHSQGNAQAFIALSLQPEMSDCLSCFIALAPAVYSGDLVRSYPLKYLVDLDDQAFTVLFGNGCFLPIMNLSQALCNPKLFCFLAYSMFSYLFAWWDSNWISRRKPKYFQFTPRPVSSQLILDWMHGWGKRGLLLHIPDNSMSLQSPPLQLLPDSLQQQQSHYHHEEQYEEEYDKGSEHNVSKKIPLAVFYGTADYLVDGEKLVRKLQKNHKQANLGKSTDPSIFLPMLELVHVERIDDYEHMDTIWGHDNHITTYPGIFQMLATAEWHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KVG5</accession>
    <name>A0A167KVG5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_172820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287026.1">
        <property type="nucleotide sequence ID" value="XM_018436879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KVG5"/>
    <dbReference type="STRING" id="763407.A0A167KVG5"/>
    <dbReference type="GeneID" id="28997785"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172820"/>
    <dbReference type="InParanoid" id="A0A167KVG5"/>
    <dbReference type="OrthoDB" id="1938621at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120510">
        <property type="term" value="C:mitochondrial [4Fe-4S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000006">
        <property type="entry name" value="Iron-sulfur cluster assembly 2 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="6">
        <location>
            <begin position="35"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD68986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="133" mass="14988" checksum="BC95DFF6ECD4903D" modified="2016-07-06" version="1">MSYHYVLSYNGSNVSQLFLDRHTLLQLKWIASRDHDDNLMLRIIVDSGGCHGYQNKLELTTEVNPDDTVFEKEGVRVVVDEISLPFVRGSKVDFVEELIGSTFQVVENPNAKNSCGCNISYDIDIDKISQTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L3V4</accession>
    <name>A0A167L3V4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_66238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287577.1">
        <property type="nucleotide sequence ID" value="XM_018441612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L3V4"/>
    <dbReference type="GeneID" id="29002518"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_66238"/>
    <dbReference type="InParanoid" id="A0A167L3V4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="101" mass="11420" checksum="1CD51B7E6C31A4F3" modified="2016-07-06" version="1">MDRLLWLEICDQPILRKSASVLLGKLDLDDVAHTDKLKVYAQNSLPVELKKASENNQVYLKVPRLIATPNTRSPAPSKNYPPTRCYAPSAMLKKDQCKIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LPM9</accession>
    <name>A0A167LPM9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CCCH-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_64069</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288898.1">
        <property type="nucleotide sequence ID" value="XM_018441227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LPM9"/>
    <dbReference type="GeneID" id="29002133"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64069"/>
    <dbReference type="InParanoid" id="A0A167LPM9"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1350">
        <property type="entry name" value="Pneumovirus matrix protein 2 (M2), zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD70858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="191" mass="22080" checksum="816CD62683487364" modified="2016-07-06" version="1">MIMIMMIIKYGFNCSLVSFFFMFKNTPHITKRFPTPCRYYAQGSCRAGQECVFSHVLPLQGKPSEIPHPVLLCPSDDMANSLQSAIRDLELDQLENKYRPFYKSTNITTLVTIIELVIPSNHPLLAHFFLFIPSDYPDAHCVLQLDSSLSLEIQSRVQQAFEDHAWHHNRHTTLVQQLDWLCTHHFSLFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LSG4</accession>
    <name>A0A167LSG4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_171059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289039.1">
        <property type="nucleotide sequence ID" value="XM_018436493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LSG4"/>
    <dbReference type="GeneID" id="28997399"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171059"/>
    <dbReference type="InParanoid" id="A0A167LSG4"/>
    <dbReference type="OrthoDB" id="2207231at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="42931" checksum="D98E97A84A4B0945" modified="2016-07-06" version="1">MGSFLGDHAITSQGTSFLQWIQATGLTCWNELLAFGIPIFLSGSSGTSRSSVIDLFLSTSPLLNPSMQICFDLSLGSDHKMVNLTFTPYVLPPPPPTNHPRLLWNLSKLAQPDTLKIYIDTASGSLDNLTEQFSAFLSSSPPPVDSLCSAFAQAIYDALDTAVGRRTPRIMQKYWFWSVDLQEAMDLRERSYQHWRHSSGLQKAICWMRHQDACHAVRLSVQHRRCETWKEFCNKLATQDFAKTTATMKRIKSHHQTSPVFVDPGGPQVAANKMADHLQQIFSGQFLPVRRPPDQTVMISSPIAIDESCPFTHLSVESAILKLPTRKAPDVDHLHAEMLHPIVKQVSPVLCLLFQLCWQWGNETKGCDFIFTVAIFLRDFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LUA7</accession>
    <name>A0A167LUA7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_170505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289157.1">
        <property type="nucleotide sequence ID" value="XM_018436362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LUA7"/>
    <dbReference type="GeneID" id="28997268"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170505"/>
    <dbReference type="InParanoid" id="A0A167LUA7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007890006" evidence="1">
        <location>
            <begin position="18"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="164" mass="19331" checksum="F3F4020963D1CE5F" modified="2016-07-06" version="1">MAFFCFLLPVMLKIKVAVENESLNIFLCQPRLSELLSDNTETYFLETQVLINASQGSFDYHTLLALSWLSRDHLPYHIFLRLPCLLSIDFCNIEHNLSKRSMQGFLRSRLLVNMMRAEMLYYNILYDGKIDPVQWKFNRFFCELGMSYCVAQLSDQNALYHLFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M8S7</accession>
    <name>A0A167M8S7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal RNA-processing protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_181976</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core complex (Exo-9) which may associate with the catalytic subunits RRP6 and DIS3 in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric base ring of RNase PH domain-containing subunits and a cap ring consisting of CSL4, RRP4 and RRP40.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290184.1">
        <property type="nucleotide sequence ID" value="XM_018438545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M8S7"/>
    <dbReference type="FunCoup" id="A0A167M8S7">
        <property type="interactions" value="417"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167M8S7"/>
    <dbReference type="GeneID" id="28999451"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_181976"/>
    <dbReference type="InParanoid" id="A0A167M8S7"/>
    <dbReference type="OrthoDB" id="437922at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11370">
        <property type="entry name" value="RNase_PH_RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000004">
        <property type="entry name" value="Exosome complex component Rrp41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="45"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="9">
        <location>
            <begin position="178"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD72144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="268" mass="29780" checksum="AC2A946D0E5D0D98" modified="2016-07-06" version="1">MFVAIGSPKRLSLYTISSSSHYGMDSRVELLTPEGLRVDGRRANELRKITAKTSVFSQSDGSAYIEQGNTKCLAAVYGPREVRHRMQALADRAIINVEFNVAPFSTSERKKRSKNDKRSLEVATFIRQTFEPVILTSQFPRSQIDIYLQIFQHDGGLLQSCINAATLALIDAGIPMLDYVCACSAGCIDKVPVLDLNNLEESADTPELTVAILPRTGKVNLLEMESRLHIEKLASVTELATEGCMQIHKILDDVVRKNTQHLKDRLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MEY7</accession>
    <name>A0A167MEY7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_145975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290699.1">
        <property type="nucleotide sequence ID" value="XM_018431570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MEY7"/>
    <dbReference type="GeneID" id="28992476"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145975"/>
    <dbReference type="InParanoid" id="A0A167MEY7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="227" mass="26597" checksum="EE393AA31BE65CBB" modified="2016-07-06" version="1">MKAGQDTIKLELNSIREELNSKIDYLQSQLDNRGFSEQETVPSATDIPCNSFIHAPILNTWDITLKHVFKMMSKDFGIEINNEEKATLRVCTKIICDKLAVHSLIKDLDSSPSWESIPVIVRKQMCAKHATLMKDASIDLIRCHENWVFTSRISHLWRDHFRRLQSRKPLMNPGERHQENFDKKTLSQFEIEERVQELLPKELVNDYKKNWHVPHIPEEQRLKNTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MVY4</accession>
    <name>A0A167MVY4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_63844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292244.1">
        <property type="nucleotide sequence ID" value="XM_018441192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MVY4"/>
    <dbReference type="GeneID" id="29002098"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63844"/>
    <dbReference type="InParanoid" id="A0A167MVY4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="187" mass="21416" checksum="4E10EEBF6C2F1DCA" modified="2016-07-06" version="1">MAGFTQSEKFLPPSPKKIMTKIKAYFKIKLLISNNTQRLQALNTRLYPCLLYYIHNTSIKYDLLCFQSISIDIDCLTSHPYLERTTRDTQWGLYPDSEPASSQTPGSHDHLFTTSNKSQYDSYHCLLDHFVGSGDPVLPTLLKKYLRVGRIIPATNEIWAAPKSAKWIYIIVLALIDSLMPFKLEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MWH8</accession>
    <name>A0A167MWH8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_167695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292314.1">
        <property type="nucleotide sequence ID" value="XM_018435693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MWH8"/>
    <dbReference type="GeneID" id="28996599"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167695"/>
    <dbReference type="InParanoid" id="A0A167MWH8"/>
    <dbReference type="OrthoDB" id="2268299at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033579">
        <property type="entry name" value="TMEM128"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31134">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31134:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20479">
        <property type="entry name" value="TMEM128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="173" mass="19448" checksum="04D4B3AF5CDB697F" modified="2016-07-06" version="1">MILTIVRQLYLMYKRPSRSERSKGLQKTDNKYKSQGHPLQTALSSLPQLAISLAILFMIVVTNTSNQQPNAYSSLTNNDTLHSLLWLTIASAGSLCLGSVFIYLQINNANYKDWKEHSWTRQAIQIASIAFVITIPSSHIALWPIYGWTTPFVVIPAFVTIFTCLHIGTTFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N4F1</accession>
    <name>A0A167N4F1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">L-type lectin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_111328</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292999.1">
        <property type="nucleotide sequence ID" value="XM_018428208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N4F1"/>
    <dbReference type="FunCoup" id="A0A167N4F1">
        <property type="interactions" value="345"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167N4F1"/>
    <dbReference type="GeneID" id="28989114"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_111328"/>
    <dbReference type="InParanoid" id="A0A167N4F1"/>
    <dbReference type="OrthoDB" id="270293at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07308">
        <property type="entry name" value="lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000095">
        <property type="entry name" value="Lectin family integral membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF45">
        <property type="entry name" value="RE50040P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007890585" description="L-type lectin-like domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="7">
        <location>
            <begin position="32"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD74959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="309" mass="35435" checksum="7CB7382ADBFD3BCE" modified="2016-07-06" version="1">MRPFLALVFSAWAFLPGVLAQVSSDQNNQQAAVPLRTHSLSVPFIDDDLQNRWFDFGGNAIVNTNHHIRLTGNRPSQVGFLWSRLPVTATNFEIEFEFNVDGPTGHLYGDGFALWLTKQRTSTGPVFGSVNQFEGLGVFFDTYDNERAHKHTFPYISSMLGDGIKSYDNDKDGRPTELGGCEADFRAREIPTKARLTYYKDNYLQLDVQWREENVWEECFKVHDVKLPDQFYLGFTAHTGELTDNHDIVYVTTKTLIPKPKEYIPVSRMICIGKGRNMYKLGFFINFCHYRPHLLPSQRKSLVDSLCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N6D0</accession>
    <name>A0A167N6D0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_181073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293164.1">
        <property type="nucleotide sequence ID" value="XM_018438414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N6D0"/>
    <dbReference type="GeneID" id="28999320"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_181073"/>
    <dbReference type="InParanoid" id="A0A167N6D0"/>
    <dbReference type="OrthoDB" id="10601492at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD75124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="503" mass="58351" checksum="10329AFB63617BA0" modified="2016-07-06" version="1">MSDNNSFDEFDDFDDLDDFCTEETFAILDRLEHEQEASQATQLNTLSRCLQDVTLARQQEQQQANCSIGNPQEEIDRLKHMVQCLQEKIECMNEASKEEEHKISQERIQLNFQRQEIESQKLKMLIVEQAKQLEPKDQSIQSDKKRKIFPDQSYFHHVPSKLSQQDNKTVHYQTQSTIKPTVDSVPGPSVQPIAPLHVLPLPCSPSTPVYKVSDSPSENSRQFTKEPPSSSSLASSEKRVYTPSVSIRKKSNRLDHLFASLRNDWSKRDTALSELDPEEAHKLFINQLRPDQDTASYTYRLNQLANEIDSLLRRSPHTPLQTTIWVFLRLVKEAFYISINRKEARLIARYLEILSVLTYYYDEACFFMAFEDNQGHIPSLLKIIKSSIAYFTETIQRDNQYKIFFCQKKMSLEELCNKFKYETPDSLEISMMVVACKKDVTKGMNYILDIFGNLLMLPVEHASSCLAEFPLDEINDIVKYDTKEVARLKQLRRAYESMCKTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N8P7</accession>
    <name>A0A167N8P7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">No apical meristem-associated C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_166593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293380.1">
        <property type="nucleotide sequence ID" value="XM_018435440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N8P7"/>
    <dbReference type="GeneID" id="28996346"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166593"/>
    <dbReference type="InParanoid" id="A0A167N8P7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029466">
        <property type="entry name" value="NAM-associated_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14303">
        <property type="entry name" value="NAM-associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="No apical meristem-associated C-terminal" evidence="1">
        <location>
            <begin position="19"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="159" mass="18511" checksum="9656268F0B235543" modified="2016-07-06" version="1">MDMILETKLLYKTQNNNETFNLDHCYAVLAKAPKWISRLEGSSRIQKATNEQLLAARAGQSSEEEDGRLICRAQSNTINQRKRTIEDALFDLIDNQKRSRVSDNMKAKFLQDMLDFKYMTVDTETITDPTRRRFFLLKQGLALRRAEKDAEETEDEDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NES5</accession>
    <name>A0A167NES5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_72828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293768.1">
        <property type="nucleotide sequence ID" value="XM_018442727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NES5"/>
    <dbReference type="STRING" id="763407.A0A167NES5"/>
    <dbReference type="GeneID" id="29003633"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_72828"/>
    <dbReference type="InParanoid" id="A0A167NES5"/>
    <dbReference type="OrthoDB" id="2283106at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="303" mass="32836" checksum="0DF0614CF3984AEB" modified="2016-07-06" version="1">MSTLLPSSVMQGMSPDLASFLGNMQAQFMSLQQRTNELESLAATNARLTTQLVNAEKLIADLRSQLASQGNCQITTNASISSAPTTPKEPGTEASTWATTAAAAHNSVVVPTALSVCKTPRPPSVRQVAASARMFAIPTGLKGYQYVYIPRSRRLTHREVRNSLKTLGVDTGRILDINFPAKDVVGILVHNQYAEKFQTTLTTVAIEILDAFDPLDPKNIADPKYKSLSDSELEEVAAELHSDRCMKALKYLRPHVAVPVGHFFCDQGWISKEDIPVHSVSGPGAGIHDFQSPSCRTSVAMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NGQ6</accession>
    <name>A0A167NGQ6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_123266</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293900.1">
        <property type="nucleotide sequence ID" value="XM_018428916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NGQ6"/>
    <dbReference type="FunCoup" id="A0A167NGQ6">
        <property type="interactions" value="113"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167NGQ6"/>
    <dbReference type="GeneID" id="28989822"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_123266"/>
    <dbReference type="InParanoid" id="A0A167NGQ6"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005052">
        <property type="term" value="F:peroxisome matrix targeting signal-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF0">
        <property type="entry name" value="GH08708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="336"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="441"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="475"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD75860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="591" mass="65938" checksum="F825A8D1083601FD" modified="2016-07-06" version="1">MSFSNMAGGADCSAGSNPMAQMLKQFNQDRSLQRDRFGVPAQGGSGSSSMRTMRQAPMTASGDGMVDEFFGQEQQQHRPAGPNVAGQIGNNFQFSELSRELESIRQQDQGGWANEFGMHSNGPKIWEVTADQEAAMEKAFEESMARAGPSQDISVWRNEFMNHPEVSQMNPQQLSEFEHAFQKHFDWAGEFDMHSSKGKGRIVELDNNASWEDQFAAFDKAETEEEMARKIEEAAAAQDPAMFDQFESVWQDIRDQMTGKGEFGDDNSWEDEFGQFNSNGPVYKPDLGDYVFEIDNPFLTHPDPLSEAIRLHDQGQSLSETALAFEAAVQRDPSNSDAWMRLGMIQAQNEKEEPAIRALEKAVEVDPGNLSALMSLAVSYTNESYDHASYQTLERWITERYPEIGGASLPAPASPFELHARVTDMFLSAARQAPDGQQMDPDVQVGLGVLFYGSGDLEKAVDCFVAALKGRPNDYLLWNRLGATLANNGRSEEAIDAYHRALELRPSFVRARYNLGVSCINIGCYKEAAEHLLTGLSMHKRGPHDAEEGVNVSSNLWEMLRKTFVMMDRKDLADKAVAGSNIQQFRNEFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P5R6</accession>
    <name>A0A167P5R6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_141185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295339.1">
        <property type="nucleotide sequence ID" value="XM_018430543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P5R6"/>
    <dbReference type="GeneID" id="28991449"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141185"/>
    <dbReference type="InParanoid" id="A0A167P5R6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD77299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="52" mass="5543" checksum="8FA8C96E576F4233" modified="2016-07-06" version="1">MNVVMKTDDHRTVTTAGTLPQSGAIRHGSWTGRHCCEARSLAPSVVVPLVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PCE5</accession>
    <name>A0A167PCE5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_141528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295698.1">
        <property type="nucleotide sequence ID" value="XM_018430609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PCE5"/>
    <dbReference type="GeneID" id="28991515"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141528"/>
    <dbReference type="InParanoid" id="A0A167PCE5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD77658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="146" mass="16303" checksum="03F2292B72FBD193" modified="2016-07-06" version="1">MHAVDSMVVGMIWWRRARIEKQFYRAFYQTFRQWYGMVCRQTLFQQAGVRLGVFTYGAERVMAPGSHGTIVGAKHVLHQKPRINSAIASTTAFADNVVSTLTDLATSSLSVNDNFDVSDNVTKKPNKADNTDYDTGDTVANDTTEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q0E1</accession>
    <name>A0A167Q0E1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_163952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296898.1">
        <property type="nucleotide sequence ID" value="XM_018434911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q0E1"/>
    <dbReference type="STRING" id="763407.A0A167Q0E1"/>
    <dbReference type="GeneID" id="28995817"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_163952"/>
    <dbReference type="InParanoid" id="A0A167Q0E1"/>
    <dbReference type="OrthoDB" id="2389915at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="670" mass="75060" checksum="1A47F3B2B315AD5D" modified="2016-07-06" version="1">MSSNSILDTKSCRAQCFKNYYRRHNDIQTSQTTPVPGQVSVVLNTVSNDTIKECADAIKDQIMDTLNSKDNDDPIMNIFSNDDNDESMYDAELGNDMDIIENKTSPLVFDFSQPAPTPDKDNAKNLEFLKIIKDFGISRNAHEMIVKHFNSILETSTCIIYKACTPHLGKKLLKHFSGVEETVHDICQRTLPSTNIRTLESFQNFSQASASSYKGLNGQSPLATLKVFSRPLFFALDEMHGLCHGISKQVWGLVSGTYGTDHCFALSSGVWKEIGTAMYKTRNTIPTSFHGNWRDVYKNPGSFKAVDWADFLLFVVPTLVAEHIGDATARNTLLGLVQACNLLMSWELSAEEQTSIKSKLEIWNMYLESLLTSGKIKINIFTINQHLLQHYPLMIDAYGPPRAYSARSVERAIGEYSRAIKSNSAINVNAGNIMLGLAQIRQAEAGATVMITEARTARHLQYEDSTAGWLLTDEGERVGARSDIEFWGPLRNRTIRDSFEGISCLSKLLEDFYESKGEECSMIEAAIQTSRKAFVNGCVIDSALDQNCVREAHNIRLQIQVDENRNINSAYSLVYKDFFGIVVVFFEHKLNKKRWLLALVEIAAVRLVNGIPVVNNEQMKPKVVHLTDVKELVGLVKLDMTINTTTTTTYIVWPKLNRSPKLSLGSLADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q0F8</accession>
    <name>A0A167Q0F8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_140915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296904.1">
        <property type="nucleotide sequence ID" value="XM_018430482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q0F8"/>
    <dbReference type="GeneID" id="28991388"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_140915"/>
    <dbReference type="InParanoid" id="A0A167Q0F8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="152" mass="16870" checksum="3B235B53583B58C0" modified="2016-07-06" version="1">MQSEPMFESITISQHCSLNLAMLKSTFWNINISPGVYLFVAKKRAEEEVTLLKCDAFWLQHCAVKERYFFLLESSSSPSSVPSASSSSIPFASSSCIPYVLSFISSSSLIVEDINFPNDGEVSITFVVEGDDDDDNDNDDNDDNNDDANENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q8M4</accession>
    <name>A0A167Q8M4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_5581</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297316.1">
        <property type="nucleotide sequence ID" value="XM_018440203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q8M4"/>
    <dbReference type="STRING" id="763407.A0A167Q8M4"/>
    <dbReference type="GeneID" id="29001109"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_5581"/>
    <dbReference type="InParanoid" id="A0A167Q8M4"/>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF363">
        <property type="entry name" value="PROTEIN SON OF SEVENLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="3">
        <location>
            <begin position="10"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD79276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="198" mass="23294" checksum="FBF4FCB94DC7AB55" modified="2016-07-06" version="1" fragment="single">SYKPFVLRHRSEIVAQQFCIIEQQMLQNVTWDELAELRWRKRSRAMASNASNPSTDILEEPCVREGVDELIGFFNKICQWVASEIVRTRSIETRVQAIEKFIRIALKCYHQRNYSTLMQVLLGLQSPAVSRLEKTWQRVDHYELHIFGELKELAKPFRNWKNVRDCMTRHTLSGRGCIPFLGLYLSDLVFNSELPTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q900</accession>
    <name>A0A167Q900_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_139323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297329.1">
        <property type="nucleotide sequence ID" value="XM_018430197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q900"/>
    <dbReference type="GeneID" id="28991103"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139323"/>
    <dbReference type="InParanoid" id="A0A167Q900"/>
    <dbReference type="OrthoDB" id="2256270at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD79289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="42119" checksum="12E361D0664CAD9A" modified="2016-07-06" version="1">MNVNASDTMGSTPLDTTSSLQEDGRIFIPFDVTFSIVFVSIGMSCFVWQTIESGWIFHKSHKPLHGIVFAQAFLGVVVTFVTLLTSFVEISCTFRLLFSVVGVNLGDFCLQYVLLCKAYIGNQRSKIVLFFGALPLLGILIVIILNFTLSRSESYYDNGVCITNYPLYGVIIKTAVDSISNTMLSYWFILVIYRQYKLFGTSVQKTLIAEAGYLSSYLIIKQLKYVKESPDADNRASDEENQSIRSRLRHDFMEPERDTLSLHLPFDSTVNYSFTSRPSYVIQKHSGFTEKSVINTTTNTNTNTTTIGHDICPPSPFSVQSPLGDTISEMLFCSPRTSSRRPLGSEGTFGWSQTTLPDEENKDSPTSSPKNQHRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q9X3</accession>
    <name>A0A167Q9X3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_58388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297379.1">
        <property type="nucleotide sequence ID" value="XM_018440309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q9X3"/>
    <dbReference type="GeneID" id="29001215"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_58388"/>
    <dbReference type="InParanoid" id="A0A167Q9X3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD79339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="210" mass="25137" checksum="D93BF73EBA39AB61" modified="2016-07-06" version="1">MIRRFHRRDRGSIPRWGTHFAESVYNCTEPFLKPVVFDLVVLILRLSYKCQKRNTRLRLDNTAKIGQTHWESYVVPNLGWSSFYYNKVKRNSHYTAVNAQEDITAHKEVLRLTIFRFYGFIKIMSDTRKEGLILLQTFLITTKSCLSLKKFLRERIEDLRLGTKIRENLCRFCLLRKDFVSKFDQVPTLNYYCYLYCFGLGRLYDWGQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QA02</accession>
    <name>A0A167QA02_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_162421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297386.1">
        <property type="nucleotide sequence ID" value="XM_018434616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QA02"/>
    <dbReference type="GeneID" id="28995522"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162421"/>
    <dbReference type="InParanoid" id="A0A167QA02"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD79346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="346" mass="38625" checksum="1D5AC94B9CFCC2BD" modified="2016-07-06" version="1">MPSNATRKSGCKGKQNVRGTLSRVAASRIEQREIAPRVSPLAAGPSGAEAPGMTVESLTQVMAAINMMYDCTAEANTGIRFLVDAHNQAIAQQALVASSVTQGVTAANVSTNRHTKGEMHAIVLNLINGRIWARNFHSNDPELVAENESRRRWNTNERIDHPDNVEYIVAQPRTAGFWEDMIVQKIKNNYKTCFHAVNATPKQASSKRRNNHINSRRIEIHLRCVDTCINNWLAIDTKMGYKPGNPDEMAYLHLLEKSVMSDGESEDEDVTPIIRVQVLQVACPSWRSAELNRLIQFIDFLAAENDKKIATPQSKQRMPRYLKAIAVTPVPSHLTAILPVWTIQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QJE3</accession>
    <name>A0A167QJE3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_58835</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297829.1">
        <property type="nucleotide sequence ID" value="XM_018440390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QJE3"/>
    <dbReference type="FunCoup" id="A0A167QJE3">
        <property type="interactions" value="251"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QJE3"/>
    <dbReference type="GeneID" id="29001296"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_58835"/>
    <dbReference type="InParanoid" id="A0A167QJE3"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="119"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD79789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="334" mass="37629" checksum="F7A85621FE8F79C5" modified="2016-07-06" version="1">MSSNVGMAVANGALPIIAYGLLIYTWYIYVFRVCQPLLLNQDQAAMGGIFIFITTALWWFSLISYLRILLSHPGKPAQISPTIYSPSLFDISTMTTQPLSLRDEIPLPLLSLSRADGGLRYCTICCCYKPDRTHHCKECNSCVLKMDHGKNKRGSARSLIASYPVVIVHGLYGVWCLCSALPLVVNAVQYKDFLLDPQWIALLILAFIFGFTIFGFAASHCYYIMRNETTIEHINDRPYEVRVDFDPSGTNYEIVSVQCTDMLWDNGISLNWRATMGSNPLGWFVPLWGGMGDGSVHPYNPTVYYTVVERAKCQRMMLNPHSLCEQDALVMLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QM21</accession>
    <name>A0A167QM21_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_139915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297944.1">
        <property type="nucleotide sequence ID" value="XM_018430305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QM21"/>
    <dbReference type="GeneID" id="28991211"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139915"/>
    <dbReference type="InParanoid" id="A0A167QM21"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD79904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="58" mass="6222" checksum="A312BB0431DFE3A2" modified="2016-07-06" version="1">MAGQQKAFLPFTQTSTFSLQGLCQHTEGWGCYGDPIGVSIDRCNGPNTDSSQTHPTCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QN55</accession>
    <name>A0A167QN55_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUMO-conjugating enzyme UBC9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme E2-18 kDa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_15132</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297998.1">
        <property type="nucleotide sequence ID" value="XM_018432667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QN55"/>
    <dbReference type="FunCoup" id="A0A167QN55">
        <property type="interactions" value="1212"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QN55"/>
    <dbReference type="GeneID" id="28993573"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_15132"/>
    <dbReference type="InParanoid" id="A0A167QN55"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019787">
        <property type="term" value="F:ubiquitin-like protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000035">
        <property type="entry name" value="SUMO-conjugating enzyme ubc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="13">
        <location>
            <begin position="5"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD79958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="159" mass="18658" checksum="76632FEBEA76CDD6" modified="2016-07-06" version="1">MSTGIARVRLMEERKQWRKDHPHGFWTRPIKNEDNTLNLLHWRCGIPGKENTPWENGIYKIDLIFPEEYPTKPPKCKFTPPLFHPNIYPSGTVCLSILSEDDGWKPAITIKQILLGIQDLLNDPNPDSPAQHEAYELFRKDKKEYEKRVKEQAARNRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QU71</accession>
    <name>A0A167QU71_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_160927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298319.1">
        <property type="nucleotide sequence ID" value="XM_018434310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QU71"/>
    <dbReference type="STRING" id="763407.A0A167QU71"/>
    <dbReference type="GeneID" id="28995216"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160927"/>
    <dbReference type="InParanoid" id="A0A167QU71"/>
    <dbReference type="OrthoDB" id="2284923at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="32568" checksum="C3820BE6AC11671E" modified="2016-07-06" version="1">MATLNSVGACRSGFSLLLSSRLYKTFVRLKFEYGLAISTLLKQDIKVLESIQDKCLCMIVGGHATSSTIVLKHICNLPSMKFCADALMAKFCIRSRFLPAQCLLSLLHRHHTVYSSLVSLRKTHLLSNLPPTLKLRSPSVVKNHFESIREAGFATFLQSNTQVLIQACHPVLGVDPILFLPASRVERGRLIRWRMGWLPGKPKECPCGSDHTSRRHLLNCPLVPATLFEQLPQPDHDQIHRLDFAISSLPLSSQEPRHAYWIPLLTILWHIDVICNPDGNYSYETEHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R079</accession>
    <name>A0A167R079_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mini-chromosome maintenance complex-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_76751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298581.1">
        <property type="nucleotide sequence ID" value="XM_018443186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R079"/>
    <dbReference type="FunCoup" id="A0A167R079">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167R079"/>
    <dbReference type="GeneID" id="29004092"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_76751"/>
    <dbReference type="InParanoid" id="A0A167R079"/>
    <dbReference type="OrthoDB" id="329666at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019140">
        <property type="entry name" value="MCM_complex-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489:SF0">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09739">
        <property type="entry name" value="MCM_bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD80541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="64195" checksum="5FEF28ED17679E61" modified="2016-07-06" version="1">MSITTDQAIQSPLLLVSSLFETFIQQPNASPAEFDPSTIFSKLFETTEQRRQIPSINDVSVQHVPKNTLVRFRCMVQDTGLGQEMFVTAYNKHDHETGAEKILCYRYTDDSMDIEQNGCSFDSVPNEYLSERTNVYCVSPPGETPWAKTTHGSLDLSHALNQLNIQDALKEPVNGTSKKYPLPGHEHVSALVKFYDSGDSLRVGQLIEVIGVLGHPVSSDGSTEDFETHMATLTNTPVLHAITYRSLENGSHGLFKPENLINASVQARDIRAKLVDYIATAFGGDKLVAEYVVLQLLSRVTVKNRGVKLGQFSLNISKFPASELGLQNEKSLEMKLDSPASKHVAFILSNLTQRCVEMPLSLEILNKSSFNPRSVDEQLNAGVLQLPNDTLLLVDETVLSEGTLDDTGVRNIQALMNVIHTQSLNYMFPYSQFELDTNLGVISLSSTKSMLPNHCTVPLQARFALTDGNLKDTMQYSNETLDMFRAYIESAKHGEYEIPDDVSEYIQEEFVNERKRAAENGTTLPSQEDLMARMSISRLVALSFGERYLTKDTFNYAVSLDEQRKGRDAGHEMPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R4S1</accession>
    <name>A0A167R4S1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_138390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298879.1">
        <property type="nucleotide sequence ID" value="XM_018429990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R4S1"/>
    <dbReference type="GeneID" id="28990896"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138390"/>
    <dbReference type="InParanoid" id="A0A167R4S1"/>
    <dbReference type="OrthoDB" id="2267841at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="233" mass="26313" checksum="36CEAE570E1EC3F4" modified="2016-07-06" version="1">MASIRKPTVRKECQCSICKSKTLEFDRVSVKTFKCHQEKDNHDITHVQIPYKDACDTISSAVSEPVNQEEDSFEFEQEDVEINSELRKEEEYEDESNVEMDNDKVALFVSLYVVNEGAVILIAIINKILQFLFDPFHLPVSVADLKHLAAFEALTSGVKKYVACSKCHAIYDNEAAPLCCISPNFGKTSLCGNSLLKSGPRSKAPKKTYVFHSIKKVLKTFFQCPDFENKINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R8X4</accession>
    <name>A0A167R8X4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CST complex subunit Stn1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_161763</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Telomere</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299168.1">
        <property type="nucleotide sequence ID" value="XM_018434461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R8X4"/>
    <dbReference type="GeneID" id="28995367"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161763"/>
    <dbReference type="InParanoid" id="A0A167R8X4"/>
    <dbReference type="OrthoDB" id="2286700at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018856">
        <property type="entry name" value="Stn1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10451">
        <property type="entry name" value="Stn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="CST complex subunit Stn1 N-terminal" evidence="5">
        <location>
            <begin position="59"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="258"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD81128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="342" mass="38771" checksum="F16641D2021FF044" modified="2016-07-06" version="1">MPKSTIPGLTSSSDSLDYYYLVFARDIALAQPSSDNLQQGSNVKFTTRINNPIQFQKAKVNGIVVSKQSFSRSNKSKDVPNAANCVWLDDSTAILRAFFTERSSRRHDFQDIAIGSQLTLFGKVRRLETNENILLCSGYNVENDLESEVYHWVKTIQQSFPDDLSKPFSDNSNNKDKDKDKDSSDNRQVIRKIPAKSIFRTLSSQVAEPKSISPETKSPENGFIDLFSENSLWEGSPSHPIFTSTPILKRPQFGSSLNSPIFPLSIGSTTTPQNQESKPEPEPEPEPEPEPEPEPEPEPDSDDKLNVDDDYDEEKQAMFDYMDEAFYYNEFVGYELDELEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167RFF2</accession>
    <name>A0A167RFF2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_184636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299567.1">
        <property type="nucleotide sequence ID" value="XM_018438963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167RFF2"/>
    <dbReference type="STRING" id="763407.A0A167RFF2"/>
    <dbReference type="GeneID" id="28999869"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_184636"/>
    <dbReference type="InParanoid" id="A0A167RFF2"/>
    <dbReference type="OrthoDB" id="2135488at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052350">
        <property type="entry name" value="Metallo-dep_Lactonases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43569">
        <property type="entry name" value="AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43569:SF2">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="9"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD81527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="322" mass="36287" checksum="2E74E4744754188D" modified="2016-07-06" version="1">MVPLPSNIIDSHVHFWHPDKILIPWQKGSIFESKPMDGMAYSQDVKRVRVQTAVYVETDVDPVHSLVEADWIARYAETLNNQIEAATAKGTETGVAFGGIGAIVAYAPVHQGKHVVAYLDLLTRLVGRRRLRGVRHLIQDPLLDPDRVRCPDFIDGVRSLASFGLSFDLNINCNHSPQQFPPIITLVQKCPDVRFVLDHMAKPPCDSKPGQDRFEFWRSQMLLLGKQPNVVCKVSGLVTETQTESWTVEQLGPFVETAKEAFGVDRILFGGDWPVCNMAVKWQTWIELLSIIIQDWPDQDKHKLFVTNAAKTYQLSSCKTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N6U5</accession>
    <name>A0A162N6U5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_25425</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441004">
        <property type="protein sequence ID" value="OAD66304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284344.1">
        <property type="nucleotide sequence ID" value="XM_018439868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N6U5"/>
    <dbReference type="FunCoup" id="A0A162N6U5">
        <property type="interactions" value="232"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162N6U5"/>
    <dbReference type="GeneID" id="29000774"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_25425"/>
    <dbReference type="InParanoid" id="A0A162N6U5"/>
    <dbReference type="OrthoDB" id="292693at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="4">
        <location>
            <begin position="2"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD66304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="155" mass="17478" checksum="0B13B89A2F018443" modified="2016-07-06" version="1" fragment="single">FSQKEVYDVVSNVKDYHLFVPFCNASHVYSSTPLGTTGTYIMKAELGVGFKLFEEKYMSQVTCKEPIMVQAIAADSSLFKELVTTWKFTPYTYPSGNLQATQPPACYVDFDITFEFASPIHAQASSVFFDQISKMMLGAFVGRCENVYRRRASSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N8G0</accession>
    <name>A0A162N8G0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_147048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290108.1">
        <property type="nucleotide sequence ID" value="XM_018431790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N8G0"/>
    <dbReference type="GeneID" id="28992696"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_147048"/>
    <dbReference type="InParanoid" id="A0A162N8G0"/>
    <dbReference type="OrthoDB" id="10392709at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24342" checksum="73F45D98B9AD3FB5" modified="2016-07-06" version="1">MASTSDDLGYLICVLPNFSTSIVEEIFDKNSAFEDWVKENPSHYANFIPNHTYIPIPTASDPSESNECLEEFYNATIFDKSLFFFFIFLTHFWLPNHLSKQDACSSSPLDEHHDTNHCSSSPRMNIIGLGSHARRSSDDLQNSSQFVTVLDGLITFIYFLHSSTMGYVYETYKSRGAIDCQKSTILSAIYLPPYSLMLSPIEEFWSKLKAGVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NEE0</accession>
    <name>A0A162NEE0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_173199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286824.1">
        <property type="nucleotide sequence ID" value="XM_018436969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NEE0"/>
    <dbReference type="GeneID" id="28997875"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_173199"/>
    <dbReference type="InParanoid" id="A0A162NEE0"/>
    <dbReference type="OrthoDB" id="3247418at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="716" mass="80902" checksum="32F0F1BA76508FC6" modified="2016-07-06" version="1">MSNNNNNSECKCSKCSPNSMGFVLVSTQTLRRHAQQDIVRQYQSGSSSSVIEVMSNDNDMEIDFEYNVDAEDQVEAEDLPLFGIDSLFDSESEDEGVIEATILDISDDESDDVREHFSSSNMPVDPTHAFIASFAAFFISKYVVNSGGAVLLKFLNEVLAHFGQSFRLPLSISGVNSMTGLSDVTRGVQRFVACGDCNKVYEESDVVPECCNFERLSGRECGNALFFATSRALTIPKKIYISDAQRKRLERENGVRWSELHDLVYFNLVECTVIDPMHNLYLGTAKRIMEKWRSSGLITDAHLAEMQLDADKLVLPEDYTPLGTKIGRGFPFMKADEWKSWCLVYSPVLLRGRLPEAHLGNWTTFVNACQYLSMPSISMAHLDEAHQSLEAFCRECEKLYKAPFLSPNMHLHLHLRETVLNFGPVYGYWLFSFERCNGILKNYATNRKDGFEGTYMKKYLEEAYQGDLIRQTLPIIRPEHSAIILELTASTANSIATSTSTATSIQFDINAFLDSPEINFDIVKGNEPLPPSALPLALKGEISMDESEYEHLLEYYRETYDDQTLVHYRQAGHSDNFVNNRIQKFESINLLGQIYKSKTKNQRGSFMQALFETSDGRSTKPYAGQIQYLFVNTAVNSFAGHVSQHVFAYVRWYKEVLLQPRAGEGVEVNEVGFEDDSMNSILPVHRICYPVAVGEHLGLEGEVQMCVVPLPRKIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NHE9</accession>
    <name>A0A162NHE9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_116092</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">G proteins are composed of 3 units, alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G protein gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287764.1">
        <property type="nucleotide sequence ID" value="XM_018428500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NHE9"/>
    <dbReference type="STRING" id="763407.A0A162NHE9"/>
    <dbReference type="GeneID" id="28989406"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_116092"/>
    <dbReference type="InParanoid" id="A0A162NHE9"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000003">
        <property type="entry name" value="G-protein complex gamma subunit Ste18/GpgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041848">
        <property type="entry name" value="Ste18_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50058">
        <property type="entry name" value="G_PROTEIN_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="12">
        <location>
            <begin position="17"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD69724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="87" mass="9682" checksum="86177FEA2848A147" modified="2016-07-06" version="1">MQTTHTSTAARQSQDVSASKLKRLLDHNEHLKDQLNVPRTTVSEAATRLVDYCNSTKDPLVPSVWGAVDKKEDPYGPTKKSHCCTLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NIX4</accession>
    <name>A0A162NIX4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_148656</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288134.1">
        <property type="nucleotide sequence ID" value="XM_018432130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NIX4"/>
    <dbReference type="FunCoup" id="A0A162NIX4">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NIX4"/>
    <dbReference type="GeneID" id="28993036"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148656"/>
    <dbReference type="InParanoid" id="A0A162NIX4"/>
    <dbReference type="OrthoDB" id="27823at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018808">
        <property type="entry name" value="Muniscin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF7">
        <property type="entry name" value="NOSTRIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10291">
        <property type="entry name" value="muHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD" evidence="6">
        <location>
            <begin position="533"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="349"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD70094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="771" mass="86949" checksum="C989A177AAE4546F" modified="2016-07-06" version="1">MANEATPYLSAFLTERPRDGIDMIQSRIRSSLKLNEELAEAHAEDLYAKSLVKLSKKLFISDKSALGHLTPIWEMLSNEVTEVSTIHAVMSFKITEEVERPLRSSMQQDPDYATVRSMDSQFQKISRDYDERQLKMIKHKKTAEKTRKPEAEAKLAESTRAIEDIRAEWLRSGRDYVLKHQAVDEHRIYNLKNAIQSFESLQTNQLLKRLAGHVAEAASQFKVEDEVTAFCNASPTVSFSGEMHGQPQPLPQFHSLPQSQSQPKFQPHSRSISLESGHQELPTSGSDNSLHVRSKKTFSTFISIRRKPKQENGYISTDSVHPPHTSDTQEVHDNASFFSSAMNSDIPEQDNNPDSSNNPASPTSITPPSAQKSQSTTSSMNNSTPLPRVVVDAEGYTIPPPDRAAWPEIGSLKDDDIGSDGESTFGNQRINIEIKNEKIEQEDNQHATEALSRVRSILKENQSTISKRPRGRRENMRSVMLNPSAEGHSDLMAHKNLTEDGFKTIREEEQAPEIIEVPVSPFGDVELPQLEQLPRIKVHITETIHAMFQGGQVVKSEVWGDVSIVYEGPIESASPICFKLLNANQLDQIAPNDNYVTLYQDSPDVFQINTEMFRLAGASAVNCLKYRMRHDIQVPLVIKPMWKCDDEQTRLLVKYQNKQNQTLQNIFFLTTVTGQVQTAQSIPAGQWMVEQQKMVWPMGDLETNDEQVLKAKFVTSQKGAPQPIAVRFEWHDHLVSLVNVETGENTHHVLWVSVQEVKKTVRAGKYIAEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NJA5</accession>
    <name>A0A162NJA5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CYP5206 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_111355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292778.1">
        <property type="nucleotide sequence ID" value="XM_018428210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NJA5"/>
    <dbReference type="STRING" id="763407.A0A162NJA5"/>
    <dbReference type="GeneID" id="28989116"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_111355"/>
    <dbReference type="InParanoid" id="A0A162NJA5"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF397">
        <property type="entry name" value="CYTOCHROME P450 2U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD74738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="163" mass="18715" checksum="731CC7FC8F18E426" modified="2016-07-06" version="1" fragment="single">YLADLIVGAGDTTASLLLWLFAILAEYQDVQKIICAEIDTFMMKHGRIPSFSDRLDLPYTEAALLESARFRCVSNFGVPHCVTEDGNTVQIDEYCIPKNTLVVISMYAMHMNPDVYENPHKFMPERFFGRTNSWNTSSNGSIKDRDIYMFGWGRWVYTNVYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NJC6</accession>
    <name>A0A162NJC6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_126567</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288244.1">
        <property type="nucleotide sequence ID" value="XM_018429113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NJC6"/>
    <dbReference type="FunCoup" id="A0A162NJC6">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NJC6"/>
    <dbReference type="GeneID" id="28990019"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_126567"/>
    <dbReference type="InParanoid" id="A0A162NJC6"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="570"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="640"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="744"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="92"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD70204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="818" mass="93570" checksum="40CE6FB7DF781672" modified="2016-07-06" version="1">MAPTTLFRSEEMSLIQLYIPTEIVQPCVAELGELGMVQFRDLNPDVNAFQRTYVSEIRRFDEMERQCRFFKSQVDKAGIPLRHLGLAGQFSRARSTQEIDDLEEKLRDHEGRLSEMNNSYEALQRRYLQLTELRHVLRETATFFEQADPGQDPRVSLDETDATTPLLEHDVGTGSEDPSHANLGYVTGVISRHRMQTFERVLWRSLRGNLLVKSAEIDEMIVDPDSDETLEKNVFAIFTHGKEMISKARKISESLGGTLYTVDESADKRRDTLLNITSSIEDLNNVLFTTTSARTSELSKIADNLTAWTTIVRKEKAIYNTMNRFIYDGARKTLIAEGWCPTNDFAIIKRTLKEASEATGTNLSCIVHNLNTKKTPPTYHRTNKFTQGFQAIIDAYGIARYREVNPGLFTLVSFPFLFAVMFGDIGHGFLLFLFALYLVLNEKKLALDNGEIFKMFFGGRYMMLMMGLFSIFTGIIYNDVFSLSLNLATPGFDWPHHNGTGPVEAVTNGHVYPFGFDPSWHGSENFLLFSNSYKMKQAIILGVLHMSFAICLNVFNHVYYGKKMFVWLEFLPQILFMESIFGYLIFCIMYKWSVNWWELDSEGHHIRNAPPNLLNMLIYMFLSPGTVDPKEQLFAGQGPIQGALIAIALICVPWMWFAKPYYLKVQNSKHQYETVAHEDTEALVEEEEEVEEFEFSEVMIHQTIHTIEFCLNCISNTASYLRLWALSLAHAQLSSVLWDMTLKIWFNFTGTLAVVGLVIGFSMWFVLTVGILLGMEGLSAFLHALRLHWVEFDGKFYMGDGVQFEPFAFSDIIEDNQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NJH6</accession>
    <name>A0A162NJH6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_171627</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288284.1">
        <property type="nucleotide sequence ID" value="XM_018436636.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A162NJH6">
        <property type="interactions" value="174"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NJH6"/>
    <dbReference type="GeneID" id="28997542"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171627"/>
    <dbReference type="InParanoid" id="A0A162NJH6"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21206">
        <property type="entry name" value="CH_IQGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="64"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="612"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD70244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1283" mass="148201" checksum="0AEC296A4050E7D4" modified="2016-07-06" version="1">MATLLPLRQIGVVGRDGKVEIPLTVEPEDVIGMQGRIRLQRNDQMKSSQWMDKQRNTLLAYEYLCHIGEAKEWIEACLGEEIDPIIKLEESMRDGIVLAKLAGWFAPQVVPRIVTDTKHKFLLSENINAFFKALRAVRMPQIFWFELTDLFDKKNIPKVIFCIHALSHLLSRRNLAPGIKDLFDELYFTNEELNAAQRVLDSYNVTMPNFKNVGSSLWKELKENENDNDNTHGGRYRGSRYPNKDETYEDDGDYDGEDGDDVDYLEKSKYQFRQIDLPQYVQRNHNSTRYSSKTPELASATGAVESDTDEEEEGEGEVMEFKTEQAHQTPEKVDWTAPENIKKLKSCQAAVRNWLDKKALEHVQEVHQSTFFQSRLQNIQAQARGVVFHRNFEDKRVTFETSEEHVIKLQAASRGFLARRKHQAILLAARSEKHKLLQTQHGYAKNQWSDAELGQLSTDKNPTVETVKKFMHLLDDSNLDFDSELALEDLRQRVIQHIRENKSLESHVTKLDIQISLLVRNAITIDEVIKTTGAFNKQQQQQRRYTQLTAASNNPNPYTLKGVDKDSRQKLELYQQLVYLLQTEPKYLARLMSITSGQDLGDHTNGHKRIESTVLALFGYATNIREEYLLIKLCKYCIAEEMRFVKDTQEFMRGNYTFMKLVVQTNRGAKEREFFRKLLTPLITLVVGNDTLDLETDPVSIYNKAINEEESRTGVLSQRKPSATSREVLAYPDIRETFILHLRNLREITENFLTAITSVIDEVPYGIRVVARELRLVLEENFPDEGPERIVKILGNFIYYRYLNPAVVKGLRNAPEQYDVIDDTISPVQRKNLAEISKMLQQISSGKVFDADDMFLAPLNDYVFDAGKRFSNWFMKLTDVEDPESYFGMDPLADMARTNKPMIYISPYELYYLHYMIETNLDSLETDQGSGNGMLADIVKQVGQSPYSPGNEHHLPETPICLSLSNRAEDIPQDPASRLKQLLVDTKRLVVYVIKSQSGPNLRAIFEEPVTEEHEENWNEVKEHEFGIQVKGTPTKDHLIRTKRRYLRLNPNDSPVDLGNITFFQLKTIAHRLVMHLEKCRVISDTNDFQDMINMIAQAITGKNSQRKQRDREIGKLTNSLEHLQVKKQYIADQRKQYDDYLQVCMNSMASKRGKRHKFMLPFTRQYFHIKRLEKQGLVPRYGSYKYTARQLHDRGIIVELSGIDKKHYDRIPIILSMDQAGIITIGGSYSGWGISSVQVDMRYESLLQTQFEGVQTMKVLDGFAKVNVNLLIYLINKKFYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NKL6</accession>
    <name>A0A162NKL6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_124304</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293128.1">
        <property type="nucleotide sequence ID" value="XM_018428984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NKL6"/>
    <dbReference type="FunCoup" id="A0A162NKL6">
        <property type="interactions" value="389"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NKL6"/>
    <dbReference type="GeneID" id="28989890"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_124304"/>
    <dbReference type="InParanoid" id="A0A162NKL6"/>
    <dbReference type="OrthoDB" id="996720at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002673">
        <property type="entry name" value="Ribosomal_eL29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01779">
        <property type="entry name" value="Ribosomal_L29e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD75088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="63" mass="7173" checksum="25CA111F9D836EE3" modified="2016-07-06" version="1">MSKSKNHTNHNQNKKAHRNGLKKPSQMKYPSLKGVDAKFLRNQRHARKGTEKALALKYASKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NM06</accession>
    <name>A0A162NM06_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_166688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293488.1">
        <property type="nucleotide sequence ID" value="XM_018435462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NM06"/>
    <dbReference type="GeneID" id="28996368"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166688"/>
    <dbReference type="InParanoid" id="A0A162NM06"/>
    <dbReference type="OrthoDB" id="2152896at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD75448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="363" mass="38182" checksum="BA25EE32C887B1BC" modified="2016-07-06" version="1">MPANTADLQAASLREESGALPPPSALFGSSRFYSTAAPSTTATAVPASATAGYCTEPTESPSPRPVFILPPPSSLPGYHLPPPHASIPYIFPPTPSPPNLSMSSRSSDAMSEAPVNNNVSGAGTGTGAGAATGAGAGTGTNGAGGASAVGGGHSYGMYYYPHQPYPMSALPQTQNSTINNIHHGDDSSNSSRLDEPPVNTATNAPNKRKRRGAVEKKKPGRQSAHQSPPSTPPNNYHYEVIELHQHEAVSAAAATLASFATASPYDTTPPSTPPYFIVPDEEEDECDDLEEAACVGLGSLECTHCGVSFRHTNCLQRHRLEHDDSWKELQGRSLSKQQQAQLLEAAQILMDIARYGMRVRVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PIA8</accession>
    <name>A0A162PIA8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_145536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291167.1">
        <property type="nucleotide sequence ID" value="XM_018431468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PIA8"/>
    <dbReference type="GeneID" id="28992374"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145536"/>
    <dbReference type="InParanoid" id="A0A162PIA8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="229" mass="25727" checksum="5D7E177B95F1494D" modified="2016-07-06" version="1">MPSTAVYVISKALSSYQWTCYLSPEPFIPLAGLLLPVASINNQFASVAEQNGSIPATRLLAISCLLGTSSKADTAHQKPNKGRKRKGQTGQQHRPKMRARSEANPAHQKPNKGRQRKGQTGQQHRPKMLARSKANPAHQKPNKGRQRKGQTGQQHRPKMRARSKANPAHQKPNKGRQRKGQTGQQHSPKMWSRSGTNQVKIHFYVHVQVHVQVQFLSKWSNNVHVLLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PIF5</accession>
    <name>A0A162PIF5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-dependent DNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_65758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291197.1">
        <property type="nucleotide sequence ID" value="XM_018441526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PIF5"/>
    <dbReference type="STRING" id="763407.A0A162PIF5"/>
    <dbReference type="GeneID" id="29002432"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65758"/>
    <dbReference type="InParanoid" id="A0A162PIF5"/>
    <dbReference type="OrthoDB" id="3691720at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="17306" checksum="D25A1F46A02C8989" modified="2016-07-06" version="1">MLLRNPDPKNSLFDSTHIIRYYFSRYIIKSNIVTGSNSGKIMFVPKIKLNPAEHTISIEVKYYQFTVHFIFGITINMSQGQTLDKIDIRMSLFVLYFVWNIKIKHPTNWKIRTPEIIMCLNYWIYSIINRQSYLAILIALIAVYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PPE1</accession>
    <name>A0A162PPE1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_69984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289716.1">
        <property type="nucleotide sequence ID" value="XM_018442194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PPE1"/>
    <dbReference type="GeneID" id="29003100"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_69984"/>
    <dbReference type="InParanoid" id="A0A162PPE1"/>
    <dbReference type="OrthoDB" id="2250876at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007838254" evidence="1">
        <location>
            <begin position="24"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="319" mass="36431" checksum="4539E139B6E4A89D" modified="2016-07-06" version="1">MTGTKFVLLFFKLLFERYLSVAAATKQLGIHVRTAQKWAAQYEKDPDSIFEKWRKTFRPRILHDEHKSAILECIDENPSIVLDEVMKKLKQMFTELKVSKTTLLDFVKQHCNLSLKKARLQPIDRNSEEKVQERLDWGALCSRVLVSLYWCEAKEDATAFVLDFICYMMLFESFEFSKLTTTKYPNVELFIVEKYNNHKLELGTKTMNVLITSSIQIDKNQSPAVGPSSTNGFSDSDAKIASQLFRAVAASVWEQGENAILSRHCVNDQQKNARQTAKFGILWMRFSGCSITAQPSTSLPSLITANAEVTRTICQIFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PR27</accession>
    <name>A0A162PR27_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_170020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290166.1">
        <property type="nucleotide sequence ID" value="XM_018436234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PR27"/>
    <dbReference type="GeneID" id="28997140"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170020"/>
    <dbReference type="InParanoid" id="A0A162PR27"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="36301" checksum="48007FC5BE6D6044" modified="2016-07-06" version="1">MTNTRRERAIALRPVEITNQQLMEILSTVRADMSTVKGQIGNVEQTLTNMNGRIGVLATTSTNTISAIDSLARTPLAAPVRAELTVAAPVVISNHEPTHEESNAVYAHIHNLMWKPKLSLRTPENILANNLKPRWDTNVAFNKSPNREIAERLLSNLEHRFGSSSMRRSDLRKRLHTNFTSRTHRERMSDDEIAETNALTRRAARADDNECRRVLAYKDNKEAIDLVMLRDCANTLQKAVMSDGESADEMDEDGIKHVIHIVQPGWRSDECNRFIALVDTYAVQAMGSSANQRIRRITTSVSNSAVPDNISPNFPRWALRDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PUW8</accession>
    <name>A0A162PUW8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_124486</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292286.1">
        <property type="nucleotide sequence ID" value="XM_018428995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PUW8"/>
    <dbReference type="FunCoup" id="A0A162PUW8">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="GeneID" id="28989901"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_124486"/>
    <dbReference type="InParanoid" id="A0A162PUW8"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD74246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="25066" checksum="131D02160410888C" modified="2016-07-06" version="1">MTLTYLVTGASRGIGLEFVKQLASAGNTVIATARNIEASSGLKALAQDNVILTTLDTGDSESIKKAVEFVSKVAPNGIDVLINNAGATGDMSLDVLNCTPEDYRKAFEINVIGTSSVTQAMLPLLRLGKTRKIVNLCSVLGSIERTENGNAWGFGMSYAVSKAAEGMLTKGFSCALKDEDFTIVAVHPGWVITDMGGKNGELTTTQSVEGMLNCVYKMTTKDNGTFFDYAGTILPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PUY2</accession>
    <name>A0A162PUY2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type zinc finger transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_167677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292296.1">
        <property type="nucleotide sequence ID" value="XM_018435689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PUY2"/>
    <dbReference type="GeneID" id="28996595"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167677"/>
    <dbReference type="InParanoid" id="A0A162PUY2"/>
    <dbReference type="OrthoDB" id="2279695at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="29404" checksum="E8DC9625042B6B62" modified="2016-07-06" version="1">MSYIDAAIAPNKHVQVPVVLFSNLSTSSNRVWREMSFPKKKPLIHEMHLTSSAICTDICTKGFPVGDQTYFPSMGIAPGTTILRISLTQLPFLPRPLLEETIKTALAAYGTVREVGLHLRSGFFDGSGFAYLERPLRPDLTLAKLSYKIPYNGGLCFLGTWKQMGHHCNYCKDMGHDIENYPEHPKDSRRCFTCDQTDHLQPVHPKAPPVDVSSFKKTRKVTAKLESRAQPPKTTPVEALKEPTEKLTASQDVATMAPKTSSMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PYT5</accession>
    <name>A0A162PYT5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rap-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_77168</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295287.1">
        <property type="nucleotide sequence ID" value="XM_018443232.1"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162PYT5"/>
    <dbReference type="GeneID" id="29004138"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_77168"/>
    <dbReference type="InParanoid" id="A0A162PYT5"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039930">
        <property type="entry name" value="RALGAPB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046859">
        <property type="entry name" value="RGPA/RALGAPB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21344">
        <property type="entry name" value="RAL GTPASE-ACTIVATING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21344:SF1">
        <property type="entry name" value="RAL GTPASE-ACTIVATING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20412">
        <property type="entry name" value="RALGAPB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="1177"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="784"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1035"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="812"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="885"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD77247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1437" mass="162484" checksum="880D82DAB76FF683" modified="2016-07-06" version="1">MFLDWIAQLRLLQHDPQTNILGPLPLGIKRTLISEITSFIYPASGKHIPDPSIFVSPAHVKWVMEVIGQGFNLPLEDMHITNDDVSIYAQWLFEPSMRPAAVVNEGLEQELYQIIFHQFSLLFQPRIPRSPSAQNNHYTNNSSSVGRPNSFNINMIPANIHTNVTSASMPMPATIANTTINTAQPTGANATPNVLKDTISQLVQRHVELCKRTLTVFATAGRSLELSPETWTVLLKVMLGITDSLLREPMGDTSIPGVVNMGDQLCDHLLRVLCELWLRSETKEVEMWDIFKDCFMRWTHRPKVIQQWSATSLALSRCVSGHLSEIEECYVVIMSVSGVQVKLDLPKPFVYYAWHRFIYLIPHPLQLAPHNFNLAMIGIGQLVSALNQKHSRVSNTKEINMPPDGNTLLHMFGTWLFDVCSKTSQNDPESHRGFAEAFATLCKIFCRPQPRQPFLRTYTERFYAALCLGLKVDACIPTILMNCTELFAIDLEGVRMLVPDFISAIKMVLPKLNIQCKCFVSVDDLRLAAIKVISTVMCLPNHFEKVELKPGWDSDLHCASDNASLIGEQEQLVTQLIRVLYADKGDVDVERPFTCLKFYILELLLMSLRTETSSYNMRYILHLINVYVVEDVPFCPGLVGTVVKLIQDKILTMKLPPDVTLVAFDVLMDFVDLYDYVKRDSKVRQNEAITAGMTRTLNTILSPKKNVARELVLALSRYVDTLINAGKLLHTYPLIVQAYDCMMKWVLVSQWIIDDRDCYQAVIATLSRGITLFDRDTDSVHVEVSSEKKKRRDTTFPPAKQLFLLPPRVNKNNNNNNSNNSNSNSSNNNNNSHSHSNSNSNSNNNSNSNNNSNSNNSNNGNNSNTNSNTSANANTNNNNSNSANTTDQQSAPSLPPSRSGSVNHKKEEIAVRMAAEYCMSQFVNQLGKFQSLHDHSLVRFRSTQRDDLCYLREYRAAKQDTDVRTAINPYDTVRYFLVDKRMILAVIDLTNAPHKSTEEPKGKPSVLLIIRDTTGSYMWEMDAVYKDPDASTPFKVSISPPATSDRRKSDPHNQPSLLYHTYGSDDDYDDDAFVVPTATSVNESELPRLDKLLKDDSEDLYQWDGIRTFIEQQKNVILQKSFKESMDKHTVYPAPPNINNDSPRGFRLLLSQIGFLLPQNREQITPIQITDSAISELETLDMLNERDCISVSVYYALSGNTTWTELVESPPPLSPLYLQFLHCLGWPVDLANHNGFKGNLDPSICEKAPYYSDRSAEFVVNVPYMLHQSPCRNDETIGQIHQRVSVDDHVCIVWIEDLVNYDELSKKIKNSSLPSSKIMVYMFIHPLKKSADGLYRIRIHIPSYTSLSGTMAASQRLNENALLFGPLVDGIVVSRHALGAMVRNTAISAHQACRVVTDTYTRPYVIRKQFIEEMGHRHRVKMPLSEFYSDIFSENRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PZT7</accession>
    <name>A0A162PZT7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_158155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293896.1">
        <property type="nucleotide sequence ID" value="XM_018433744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PZT7"/>
    <dbReference type="GeneID" id="28994650"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_158155"/>
    <dbReference type="InParanoid" id="A0A162PZT7"/>
    <dbReference type="OrthoDB" id="2339532at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="115" mass="12608" checksum="4BEC5F4C6CE2AE2D" modified="2016-07-06" version="1">MPIICAMPFFGSLFSTTKPDRIRKSIGPISSVLKRQQPYSSPARPLSQPKVNPESGKPEVVTESAILSNFPRPNLMPTLHFSLFGLQNSPPSEDTFRAKKCTNCAGPHSTDFCPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q0L1</accession>
    <name>A0A162Q0L1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_166048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294116.1">
        <property type="nucleotide sequence ID" value="XM_018435357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q0L1"/>
    <dbReference type="GeneID" id="28996263"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166048"/>
    <dbReference type="InParanoid" id="A0A162Q0L1"/>
    <dbReference type="OrthoDB" id="10372586at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="262" mass="29955" checksum="542230641B3B54F7" modified="2016-07-06" version="1">MPFNEKNSTPEHKDVPPHYSRQDRPIHNTGYRRSSMATPVQANPSRRYSTHHRPSASTTSSSFHTAVSRQPSTVEIFLKKFLDVFIFATAIAFTAYNYWTGTLALQPLKDAPQSPRAQPTLSSRQSERTKSSQFDDACQQRTREWTEDVTRKQYQHQRRHSSKSTLVEPKPILVKKKYSKASSSSSSETKRKSWSSERYAGHHDEIYNTTDESAIQAMNATKKTDERMTKISDGLELLIKEAQEALASKVEFYDTDIDDIAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q1V3</accession>
    <name>A0A162Q1V3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Uracil-DNA glycosylase</fullName>
            <shortName evidence="7">UDG</shortName>
            <ecNumber evidence="7 9">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UNG1</name>
        <name evidence="11" type="ORF">PHYBLDRAFT_130035</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="7 9"/>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297667.1">
        <property type="nucleotide sequence ID" value="XM_018429330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q1V3"/>
    <dbReference type="FunCoup" id="A0A162Q1V3">
        <property type="interactions" value="539"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162Q1V3"/>
    <dbReference type="GeneID" id="28990236"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_130035"/>
    <dbReference type="InParanoid" id="A0A162Q1V3"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000007">
        <property type="entry name" value="Uracil-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003589">
        <property type="entry name" value="PRK05254.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003591">
        <property type="entry name" value="PRK05254.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="10">
        <location>
            <begin position="47"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD79627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="224" mass="25454" checksum="CA1F91E12ADEE2E8" modified="2016-07-06" version="1">MEDGWFKALKPEMTKPSFLALKKFLKAEKEAKKTVYPADDQIYSWSNFTPLSNVKVVIVGQDPYHNVNQAHGLCFSVLKGITPPPSLVNIYKAISIDYPDFKKPNHGYLEEWAKQGVLMLNTSLTVRAHEPASHSNKGWEQFTEAIINHLNEKKKGIVFLLWGAHAQKKGSKIDNKKHLVLKAVHPSPLSAHRGFFECHHFKQTNEYLSQHGKEPINWNCLADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q3S7</accession>
    <name>A0A162Q3S7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_58813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297806.1">
        <property type="nucleotide sequence ID" value="XM_018440385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q3S7"/>
    <dbReference type="GeneID" id="29001291"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_58813"/>
    <dbReference type="InParanoid" id="A0A162Q3S7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD79766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="103" mass="12098" checksum="4B319E95B31A28DA" modified="2016-07-06" version="1">MTSCENTIESKIYVNRGTFILVSVYRFYNHLQEAQISLLPIKIKSITYVEELIVVARFKKQNVSYSVTFDTRMVCSSINIKVLKSFQFYLKKTPINIEMYLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T4E9</accession>
    <name>A0A162T4E9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_152771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441005">
        <property type="protein sequence ID" value="OAD66202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284242.1">
        <property type="nucleotide sequence ID" value="XM_018432990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T4E9"/>
    <dbReference type="STRING" id="763407.A0A162T4E9"/>
    <dbReference type="GeneID" id="28993896"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152771"/>
    <dbReference type="InParanoid" id="A0A162T4E9"/>
    <dbReference type="OrthoDB" id="3691720at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274">
        <property type="entry name" value="DNA HELICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274:SF51">
        <property type="entry name" value="OS03G0423850 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="112" mass="12755" checksum="24B729897ACD108A" modified="2016-07-06" version="1">MTRFNAGQVSLIPRIKLNPSESNSEIEFQRFQFPVYFAFAMTINKSQGQTLESIRLYPSATVFSHGQLYVTLSRVRKPSTIKIVLNTSANFNEIANTVFADNVVFKKVFDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TAW2</accession>
    <name>A0A162TAW2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_151514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285302.1">
        <property type="nucleotide sequence ID" value="XM_018432695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TAW2"/>
    <dbReference type="GeneID" id="28993601"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151514"/>
    <dbReference type="InParanoid" id="A0A162TAW2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="70" mass="7484" checksum="0438321A6BF7DA43" modified="2016-07-06" version="1">MSTIQDLTTQTCLEALEATMGNNIPLENIGHLLAGEQEIGQVPNDKTLQDIRRPGGSVPGNSWKLLAVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TJB2</accession>
    <name>A0A162TJB2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_116905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD69042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287082.1">
        <property type="nucleotide sequence ID" value="XM_018428552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TJB2"/>
    <dbReference type="FunCoup" id="A0A162TJB2">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TJB2"/>
    <dbReference type="GeneID" id="28989458"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_116905"/>
    <dbReference type="InParanoid" id="A0A162TJB2"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="170"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="124"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD69042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="378" mass="41585" checksum="72742661DC7F903E" modified="2016-07-06" version="1" fragment="single">VFVGNMSFKTTEETLSEFFKPCGNVLDATIITRGPRSLGYGFVTFSSLAEIEKATKDLNKKELDGREINVEAARPKAPKTGPTKARRTREVSKEKHISKPVAAAIVAATAGATAAGAAAVAAGISADHSKSETTDDETVRKSRPGRRARKNKNREGREIKPREPAEDSKTRIFVANLPFATTDEELVAIFKGYNIKSAAVARLKNGRSKGYGFVETESEEEQQKTLAKFQDIVLDGRTVSLKVARVERPRKVKEATSETDEQKSAPATEVKPTETAKAVEPKKTETKPTEVKKEEAKSVEVKKEVKPVEVKKEEGKPVEVKKEETKPVEVKKEESKPVEVKKEEAKPVEVKKEVKPVEAKKEVKPVEVKKEEAPKASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TJS9</accession>
    <name>A0A162TJS9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Squalene monooxygenase</fullName>
            <ecNumber evidence="13">1.14.14.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHYBLDRAFT_136751</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>squalene + reduced [NADPH--hemoprotein reductase] + O2 = (S)-2,3-epoxysqualene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25282"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13">Endoplasmic reticulum membrane</location>
            <topology evidence="3 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the squalene monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.17" evidence="13"/>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285733.1">
        <property type="nucleotide sequence ID" value="XM_018429811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TJS9"/>
    <dbReference type="FunCoup" id="A0A162TJS9">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TJS9"/>
    <dbReference type="GeneID" id="28990717"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_136751"/>
    <dbReference type="InParanoid" id="A0A162TJS9"/>
    <dbReference type="OrthoDB" id="1678617at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004506">
        <property type="term" value="F:squalene monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000166">
        <property type="entry name" value="Squalene monooxygenase Erg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013698">
        <property type="entry name" value="Squalene_epoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040125">
        <property type="entry name" value="Squalene_monox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835:SF0">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08491">
        <property type="entry name" value="SE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 13" id="KW-0274">FAD</keyword>
    <keyword evidence="5 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene epoxidase" evidence="14">
        <location>
            <begin position="178"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAD67693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="478" mass="53249" checksum="7717E3C49A41F68C" modified="2016-07-06" version="1">MSTLPILEYDLIIVGAGIIGCAAARAFGRDGRQVLLLERDLTEPDRIVGELLQPGGVNALHNLDLQDCIEGIDGIPCHGYGVFYQNKLVEIPYPVNKFTGEKAVGKSFHHGRFITKLRNAAKQTPNVTVRELTVVEMLKDKYNHKEDGQEDKGDNEEREERIIGVKAQSKDGQVLQFHAPLTIVADGLFSKFRKQVTVKTPDVKSNFVGFELKDLVLPLPEHGHVILAHPSPVLMYQISEHDTRVLVDIPGQLPSASTGQLKKYLQETVAPEIPESIRGKFLESLETERLRSMPNGFLPPSINNTKGMVLLGDAMNMRHPLTGGGMTVALNDIVLLSDLLSVENLPSFTDSELVTKTMKSFHWKRKSYCTAINVLAMALYRLFAAGEDADLAVLQRGCFRYFQLGGECVNGPVGLLSGLIQRPSVLVYHFFVVAFYSIYCEFQRAGWANAHYSFIRIFTVLYTACVTILPYLFSETKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TPW2</accession>
    <name>A0A162TPW2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_171509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288162.1">
        <property type="nucleotide sequence ID" value="XM_018436621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TPW2"/>
    <dbReference type="STRING" id="763407.A0A162TPW2"/>
    <dbReference type="GeneID" id="28997527"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171509"/>
    <dbReference type="InParanoid" id="A0A162TPW2"/>
    <dbReference type="OrthoDB" id="2379842at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22744">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="49073" checksum="DF61C8A29131082C" modified="2016-07-06" version="1">MEEVIKLESLFRSCEGSQQVANLLNKIKKVTSEFEGKTGHPSINFQAPEKIKYPGRRKGGARPKYLPKDFGRANWRKISVSSGHAGLKAMVRLRAKMREGKPAATQKTKNKKQNKNKQEPLNPVDATKNKIKQIKQEPLDPGCRLTRICFLVDATKNKTTKIKQEPLDPVDAPQKNGFKRPATALEDYQYDNRTSVGKRVKFQPGFPVSHEIIDDVKGGFSPTADGWCGFRVLAHLIYKDQNKFSLVKRDMLAALPKYKTLYTNTFGTDTSQLEKIIQHGSQLDYSNTSNTNTNFIPVCSDASMWFNTPDCAQLAADTYTRPVCVYSDNPNTPSTTFLPFALPNNKTKQRQPLIFNHVNSNHWTTVDLSRNISRKWPTVPELFFLGCARNKIDDNFDTYWNKFKEFNKHDRRNAMLSLHSDLDQPIDLTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TS26</accession>
    <name>A0A162TS26_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_69572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288632.1">
        <property type="nucleotide sequence ID" value="XM_018442119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TS26"/>
    <dbReference type="STRING" id="763407.A0A162TS26"/>
    <dbReference type="GeneID" id="29003025"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_69572"/>
    <dbReference type="InParanoid" id="A0A162TS26"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="127"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD70592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="504" mass="56936" checksum="4869243A7534FEAC" modified="2016-07-06" version="1">MHTIDHPNSAKQLQAIANLGQSPITDDLLELIACEFESIIPCTVDSGFLQDNQAPETKPYIQYKVHHDLPSPPLSSSDKQHYPSDFRKFQTLQPTTQTQIEVETEATPQSQSLPGAAAALPPPPLRAFISSVVKRSQTTTGTLLSSLVYAQRLRSKLAGTSKGMKCTHHRIFLATLITVTKYLHDTAPRNKYWVWYAQLFSASEISLMERQLLQLLEYDLAVPIDCFNQVSLSILQSTNHGQSRNTKYHDYHQQQQQQQPLISSSQRRGGNSNTSSRLPSFSTLFQMSNQIDYSNTMSNTSTSTGSNTTGNRSQSQSRTEAPQSSQSASYWQTFSGPEKSSSLSSSSSSLSSTRSLSFTSQQLQSQPQYQYQYSQLDYTSNDNYINYDNYTNNYNKHYADSPIDIWQKPFPHVANVDCESNVDRLCDFTQKEQHSWLVEGGERGRGGQRKGEEANRFGQDDSVDYRRRHSHQKELIDTTGFSSEDYCYPFQQIVLSPFQSLSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TXB9</accession>
    <name>A0A162TXB9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_148488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288613.1">
        <property type="nucleotide sequence ID" value="XM_018432098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TXB9"/>
    <dbReference type="STRING" id="763407.A0A162TXB9"/>
    <dbReference type="GeneID" id="28993004"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148488"/>
    <dbReference type="InParanoid" id="A0A162TXB9"/>
    <dbReference type="OrthoDB" id="2279134at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="35014" checksum="A606A379D94F9507" modified="2016-07-06" version="1">MSSTEKRCASCKLMGHSRKSSVLYPLYKKQNTLYIPQKRTNENISIEEEFPAKTASSRVKINPVKEQQIIVDTVVDPTIILAEEPTIEHEEETMTINESTATRHCPSCLRTNHLRITSLMCPNNVQILVQNQNPQNQNVANIARLQNISEPEIDSRGNMDVVCRFCGALMWLKEKDTDLSIRRSKFNMCCGKGKYVLPSLEPTPPGISELLNYRTSNGKNFLSKIRGYNSTLSFTSLGAKIDNSVANNQGGAYCFRIHGTICHRIGSIRPSRAQDIDHPQLAQVYIHDPASQAQHHCHHAPYLKADILEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U148</accession>
    <name>A0A162U148_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_102215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290672.1">
        <property type="nucleotide sequence ID" value="XM_018427686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U148"/>
    <dbReference type="GeneID" id="28988592"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_102215"/>
    <dbReference type="InParanoid" id="A0A162U148"/>
    <dbReference type="OrthoDB" id="2439011at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="166" mass="19167" checksum="65D1D781A0F70F0E" modified="2016-07-06" version="1" fragment="single">NLSRSVRFKKENVILIELMPDPKEAKTSEINLYLRPLADKLEKLYKRVRVQTYQCPNDTTICAALFMVVCNISTARKVCGFMSHISTNTCHKCNCQFSQLAGTSSLIRTKNNNCKNVEVWGNTTTEAERHYLEVENDICWSKLHCFQYFDVVCYTIIDPMHNLFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U1T8</accession>
    <name>A0A162U1T8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate-binding module family 13 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_187180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290832.1">
        <property type="nucleotide sequence ID" value="XM_018439344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U1T8"/>
    <dbReference type="STRING" id="763407.A0A162U1T8"/>
    <dbReference type="GeneID" id="29000250"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_187180"/>
    <dbReference type="InParanoid" id="A0A162U1T8"/>
    <dbReference type="OrthoDB" id="9895617at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23454">
        <property type="entry name" value="beta-trefoil_Ricin_GllA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="1">
        <location>
            <begin position="7"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="148" mass="16757" checksum="E5F0FDA6D3E07E1D" modified="2016-07-06" version="1">MVNYVPSGYFFIASQFNGKVLDVEKASTKDGAKICVWAKKDTDSDNQQWEYRNGHLINKYSGKALDIKGGKIKHDTRIVQEDIKEASEEADSQRWLIDPQYYIHTAADTSLVLDIRGAEDEDGAEVILYEKREGTASSNQRWNLIPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U8B8</accession>
    <name>A0A162U8B8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinylglutamate desuccinylase/Aspartoacylase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_144721</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292312.1">
        <property type="nucleotide sequence ID" value="XM_018431274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U8B8"/>
    <dbReference type="GeneID" id="28992180"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144721"/>
    <dbReference type="InParanoid" id="A0A162U8B8"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06251">
        <property type="entry name" value="M14_ASTE_ASPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055438">
        <property type="entry name" value="AstE_AspA_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053138">
        <property type="entry name" value="N-alpha-Ac-DABA_deacetylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010282">
        <property type="entry name" value="Uncharacterised_HutD/Ves"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37326">
        <property type="entry name" value="BLL3975 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37326:SF1">
        <property type="entry name" value="BLL3975 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24827">
        <property type="entry name" value="AstE_AspA_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05962">
        <property type="entry name" value="HutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Succinylglutamate desuccinylase/Aspartoacylase catalytic" evidence="6">
        <location>
            <begin position="391"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD74272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="679" mass="75306" checksum="F462DA08ECCEE86C" modified="2016-07-06" version="1">MSPRDPNAHSHSTLLESSSPEPTLLKVCSLVPETDYRKQAWKNGLGTTTEIAIYPPNTDFKKDPFLWRLSVTETRSDSTFCIFPGYDCTMIVLPNKKSEAPSLLLRHQDTEALINVKPLFPYTWEGQWTTSCRITNGPISSIHFMLNKSFGTAQSKVITIGTSATEAEDNKILMVGAFALVYVVKGSCCISLDEHRSHARTNALKQGQCLYIERDQEAGPSQMDIRVGSFASDSTKGSSTESDDSNEKVEVTLVVIQVAESTAVTEQPHTERRPSALPSEIRQGRRNSSLVVCPNQPDSAIKTPEDISLNTPREELQGAQPTWDSTQIYEPPSSAFFHFDSEMPPPMIRDRLVIEDYPLHTTSTAWIKMMTQGMNEWLKLPVIVCRGSADGPVVGITAAVHGNELNGVPCIHKVASSIDVQVLRGTLVAIPCVNVTGYLKFQREFSDGRDLNRMFPGKEDGFASQVYCFHIMNKIISQFNYHIDLHTASFGRVNSFYVRADMNDSGAAMLAQLQKPQIILHNSGQDGTLRSAAATRGIKSITVEIGNPQMFQEQFWSFMGVMRILNKLDMFPLENVLSEEKFIGPTTTILCSKGFWIYTKTGGVLEVYPDVNTIIRKGDIIARVKSMFGNVIEEYDAPCAGVVIGRSSNPVAMAGDRIIHLGIIKRKGEVLMKEAKENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UGM8</accession>
    <name>A0A162UGM8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription factor TFIIIC triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_143087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294142.1">
        <property type="nucleotide sequence ID" value="XM_018430934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UGM8"/>
    <dbReference type="STRING" id="763407.A0A162UGM8"/>
    <dbReference type="GeneID" id="28991840"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143087"/>
    <dbReference type="InParanoid" id="A0A162UGM8"/>
    <dbReference type="OrthoDB" id="1877767at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10419">
        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="1">
        <location>
            <begin position="11"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="146" mass="16262" checksum="F99E3EC6553B299E" modified="2016-07-06" version="1">MSDSDDSEEYDEEVSYVIMDVGSDCKADVIASMAKANGGARITDLEADTVYFQAGPYFFVGALDETVGLFPLLNSMKYNNEENQKLAHIKTTFKCKTTRVLMMDRIEIANQETQNGEKSIEHMDIDQQNEGPQFDGLGNALLTEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UQ44</accession>
    <name>A0A162UQ44_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHYBLDRAFT_154765</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295023.1">
        <property type="nucleotide sequence ID" value="XM_018433351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UQ44"/>
    <dbReference type="STRING" id="763407.A0A162UQ44"/>
    <dbReference type="GeneID" id="28994257"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_154765"/>
    <dbReference type="InParanoid" id="A0A162UQ44"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052242">
        <property type="entry name" value="Mito_3-hydroxyacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561:SF3">
        <property type="entry name" value="HYDROXYACYL-COENZYME A DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 12" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="15">
        <location>
            <begin position="2"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="188"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="4"/>
            <end position="9"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAD76983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="288" mass="31081" checksum="9407ECFA6619D563" modified="2016-07-06" version="1">MVLGGGLMGSGIVQVAAQAGYKVTMVDTSDAALDNGRSIIQKSLSRVARKKFADDETAQKSFVEKVFSNISTSTNADQTASGSDLVVEAIVENIDIKQKVFGALDKVAPKHSIFCSNTSSLPVTKIAEIVSADRKTRFAGLHFFNPVPAMKLVEVVRTDAVSDEVFDALFEFTAKVGKTPVACKDTPGFIVNRLLVPYMMEAFRILERGEASAKDVDTAMKLGAGMPMGPIELADFVGLDTMKFIVDGWQKEGIVEPALVKPCTILNDLVSQGRLGRKTGQGFFEYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162US75</accession>
    <name>A0A162US75_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_164440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295573.1">
        <property type="nucleotide sequence ID" value="XM_018435005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162US75"/>
    <dbReference type="GeneID" id="28995911"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164440"/>
    <dbReference type="InParanoid" id="A0A162US75"/>
    <dbReference type="OrthoDB" id="2290051at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD77533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="467" mass="52927" checksum="62DA31A54F22AD8D" modified="2016-07-06" version="1">MADYLETPGRTTLKAYIDANQSSRSPDIKLDIEEAWIETKVQRTANIQTSRVSAALLKAGGKKAVNLLKKAPPSSDETTAHVPIEANAVCNPIQPAGPSYTDISNAFLSPPTEPAANTSTTETNDTADNHNTNIINNNVVSSSNVEEENTEKLRFVLTEDEEFKSTILINEDTPECFKRFKEFQEESFKIVKKKGLFINRDLFRILSLYNIVLLKKNHAYSQIDFSMINDELSEKFESSPKIEKSIFMEIIHIFRDDISDRDELKISLFDLYKKANKQDGRVIDVLINLPLLHDPGHDKLFIWLNRTVLQNYDKRPDAGCLALKGKRLDHYVGFAEVKPDYKRKDTVKTHEDLLRLSLFGMNALEEHNSKCILLIQVIGSSMYVHGCFNRVEGAVVIVELEEFKLPMSLKDLPGFIMSLDKLKKVGHFYRLQCFGKGGNKRRAPSNVNLDDIINCHTPKNMKAAVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UXW8</accession>
    <name>A0A162UXW8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_104066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296742.1">
        <property type="nucleotide sequence ID" value="XM_018427812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UXW8"/>
    <dbReference type="STRING" id="763407.A0A162UXW8"/>
    <dbReference type="GeneID" id="28988718"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_104066"/>
    <dbReference type="InParanoid" id="A0A162UXW8"/>
    <dbReference type="OrthoDB" id="5563016at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF18">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="60" mass="7045" checksum="54127B1062D646FE" modified="2016-07-06" version="1" fragment="single">RRLLFCPTLQLHETFAASEYDRRCDPNATCQRLTPALAMHIKQELNEFKLTEMAVHIESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UZ77</accession>
    <name>A0A162UZ77_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_185398</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296983.1">
        <property type="nucleotide sequence ID" value="XM_018439074.1"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UZ77"/>
    <dbReference type="GeneID" id="28999980"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_185398"/>
    <dbReference type="InParanoid" id="A0A162UZ77"/>
    <dbReference type="OrthoDB" id="10070851at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1163"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="333"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="8">
        <location>
            <begin position="936"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="442"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="670"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1118"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="676"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1118"/>
            <end position="1129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD78943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1321" mass="148501" checksum="457AF7986723A2F4" modified="2016-07-06" version="1">MAQSARELPSLVASPTNTLTLQDVVLDSPVWRANVIHLEDQMEQFSKWIDRFIRMIKQYIESIEKHNLETSNLAKWTHPPGLDGSFLDPHVAGTVINAFIGTLQSDLAFKQKLASDLEETLLLPLQHFIKTELKDFREAKRQFDKVLDKYENQLSRYSILSKQKEPSALREDAFQTFDVRTAYTRACGDFFSRMIKFRSNLEHQLVQCFSGAMQAKIEEVDEIGQACAQIRLLLPGWRLWLEENKESCAFQLQKIQKSCSVLEDAYIRQTRPHRSLKRYSTVPNRRRSTIISGSPVLGESPDDRATIRPPSLSEHRMSLEDQNTFEALLPDDSSPRQGYLYQKCAIGKSTRYTWTRRWFFLQDGFFGNCTVGTINKVKGSLVVDERIKIQGCKGKINNDIDRRFCFEVQNPSSNITFLLQAETEDEMMQWLWAIEKQKELFSKPGSPEGSPSKLLQHKYKQQQEEEGGEDEEAEEATLPQALLSPKPTLPVKRSPAEKLTRTVSSSTCFPLRREDLLNKNQSLTSTLSTAFSLTSLMIREGTRKVKTPAPSESSSETPGQIDIVPQPSSSWGMPWLMSGINALANNGDAASISDPISSKSPSTNEAGQVVVWPTKLETETPKVKLTGYSSDLAQKQKELRKYFANVSSSEVVLQGFPASLYLQQSKQKSTDELSDRGSSTNDQASLSSQEMSSDENGFGYNGYCYVTQKNLWFYSCIMMTCVNTLVIPLDDIKFIQFDRASSATSHMFIETTSLSQRHCFGLWLESAEKIGEELRLIVETAKSPGETQLQALYDNIKSITPGRKQKTPVSHFTAVSALNAAVTPLNVQAHPSQLLSQEPMVTTQDSTNSMISSIGRRNSSTTTSVDIRGRKTSAATGALTAAMEAASPSKLSRSPPKSEKYLSQLSKTNINLPDEVWPDNIEKPTEPVTCGCQDHLDKKETEVPLHISAKRLFDMMFSESQSGEEAGSKSIWKSFNKERGNSDLKISGWSENKEGNKERILTYTMPVTNPMVKAKETNVIETHQILEEKDHLSYAVIISTRTPNLPYADAFIPCIKYCITYTSPSSCILSCSYGIKWLKSVMVKSMINRAANKGLVESIDLMIAQVKKKISLAIGASGQASSGPTSGEPSQALDISATANESHSKPDTANRTRVISLGGFKKPAMYILAVVTLWIITYISTGVYYRQTHEFSAPNETISWRGVYLRDLDQELAGQVSVPINSNPRMYQSFQDSRIEPMGWKYTWFSSRHRRMAAELTYTRERLGALRYELLAAFRMLNSIEQHIVESEYWNWLLDRNLQCENGSEQGVDGCEEVRKELSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UZK3</accession>
    <name>A0A162UZK3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_62937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD79023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297063.1">
        <property type="nucleotide sequence ID" value="XM_018441044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UZK3"/>
    <dbReference type="GeneID" id="29001950"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_62937"/>
    <dbReference type="InParanoid" id="A0A162UZK3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="148" mass="16702" checksum="D5D3C8B769EFB6C8" modified="2016-07-06" version="1">MSSTSELYNKKCYCTKCSDNQQGYSFVSTQTLQRHNKRARYEDMKRSERNISVQRNLMDIDFETTSNQQTGPIEAMDGQTNSPVWEGAPISDDEVAFSNESNGESSDGDENDNDEESNGGEESEDNEENIVEIEVEEFDTEGQSVLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V4P4</accession>
    <name>A0A162V4P4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_130286</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297962.1">
        <property type="nucleotide sequence ID" value="XM_018429349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V4P4"/>
    <dbReference type="FunCoup" id="A0A162V4P4">
        <property type="interactions" value="631"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162V4P4"/>
    <dbReference type="GeneID" id="28990255"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_130286"/>
    <dbReference type="InParanoid" id="A0A162V4P4"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016278">
        <property type="entry name" value="DUSP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000941">
        <property type="entry name" value="DUSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="5"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="66"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="5">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000941-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD79922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="341" mass="38072" checksum="88E1E88063C5B8A7" modified="2016-07-06" version="1">MSNSNCIQEIVPRIFLGTFSAGQSRAVLNQHKITHIVALGDFTPLYDDKIYLNVDIMDLPGANIIQHFDETSNFIEDAYNKNGVILVHCEAGVSRSPTVLAAYFMRSKGIKPTEALEMIKAKRPIISPNNGFLAQLVLYDRLKYDVDTRHTDYRRFLVAAMAEEQKENGYIQHFALAPDPEYVSGYDSSSTNTKPYTALRCRKCRRVLAEADNVIDHERGQGQGAFAYLKRDSSINATESAIVGLSEAGPTHDTVNKAINPLLASLASSNSSCSSYFVEPMEWIHGLQNGEFNGRIECPKCCSKLGSYNWSGEQCSCGQWVTPAFMLHRKQVDEIKNVKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V7H4</accession>
    <name>A0A162V7H4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_138157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298643.1">
        <property type="nucleotide sequence ID" value="XM_018429948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V7H4"/>
    <dbReference type="STRING" id="763407.A0A162V7H4"/>
    <dbReference type="GeneID" id="28990854"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138157"/>
    <dbReference type="InParanoid" id="A0A162V7H4"/>
    <dbReference type="OrthoDB" id="5380370at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="434" mass="48061" checksum="0A0E48F2BF0D0B0D" modified="2016-07-06" version="1">MNGARNGHYMIHSLSLDLQGNKNALGRLCLHKHALLHSLELVLHFILIVMSPSKRNLVLPSSMASPNRIFLSSIPIMSCPKTEGHSGMYSQPQEIRPFVVSKEFALRSNSYIINDRHKARKENDPLEHYSNTRSSPRVATTLADPIDPSINTWSSSNSVTSTEGSTVATSLSSQNSLLLCSSRGFLMTPQSLVESVPHSKPTALSGQLPKPIHHTPSHRGTTSSFTSAIPTALYYGSRQVRKYLRAVITPQSKSDFEDMLQHGFICSHTYTPNDDECSVRTTTTHYYDALDSLSIQPCNRCGPDHRQMTLRITLTPWHCRATETEIYGQPSAARNAHGLSVVLNKSMSTASKLSSSWLSSTVSQTRSDIISFRQQPLPTVTQSAPLVHKSDRSKKDTRKDMGKSQNVVPVQSHSTALAFGSRCSYTRQSKETRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162W711</accession>
    <name>A0A162W711_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ISXO2-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_176463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441042">
        <property type="protein sequence ID" value="OAD65055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283095.1">
        <property type="nucleotide sequence ID" value="XM_018437785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162W711"/>
    <dbReference type="STRING" id="763407.A0A162W711"/>
    <dbReference type="GeneID" id="28998691"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176463"/>
    <dbReference type="InParanoid" id="A0A162W711"/>
    <dbReference type="OrthoDB" id="424490at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053164">
        <property type="entry name" value="IS1016-like_transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163">
        <property type="entry name" value="DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163:SF2">
        <property type="entry name" value="SI:DKEY-17M8.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ISXO2-like transposase" evidence="1">
        <location>
            <begin position="149"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="322" mass="37224" checksum="25F3AFB01D83EA15" modified="2016-07-06" version="1">MPNYFQPKDMSITPDFEQIHKITESKKTSVIYLKENNILYEHMSCCNEWPITLQCHISREKFYCKCNSRNCCNRSEMSIGKDTIFSFKKMTLNIMIYLIWCFILNYVLNKTEEATKLSKKTIGIFMAGIQKVICQDISSNDSLIELLLKLMSLILKSESIIKSIELKVFGFWGVEQTSERKIFLVAVSNRTADNFLNIIQHHILSGSIIHTDYFKLYNQLETLGYRHSTVNHSVEYKISEGIHTNTIEVLQMIISIVRQIKDNNISLEQQLLLDLDPDYKTYFTENESSSFENKNAISSDSNNTSDSTDDNILYTDSILASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162W9R5</accession>
    <name>A0A162W9R5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VTT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_189513</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441008">
        <property type="protein sequence ID" value="OAD65715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283755.1">
        <property type="nucleotide sequence ID" value="XM_018439672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162W9R5"/>
    <dbReference type="STRING" id="763407.A0A162W9R5"/>
    <dbReference type="GeneID" id="29000578"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_189513"/>
    <dbReference type="InParanoid" id="A0A162W9R5"/>
    <dbReference type="OrthoDB" id="3364966at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045014">
        <property type="entry name" value="TM41A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220:SF21">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 41A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="7">
        <location>
            <begin position="89"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD65715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="291" mass="31747" checksum="1D786EA4B3A5CA71" modified="2016-07-06" version="1">MALDQTPQTPTWRDLLPRLGLFVAIALISLGFTATLANQVLGITLPRTLEDAQTTATQLEKLASSSWQDSLSVAGCFSVLYLWQQAFSVPGSVLLNLLASYLYGIGIATVWTSLLTAGGATLAYALALLVGKPFMHIGWVSKRADSMTRQMKTNKTKAGLFWWLLFIRLFPFSPYWFINMASPLLGVPALPFFWSTFLGSMPYNFVCAQAGDVLGDLTSTSDILSVSLVLKLLGVSIISLVPVLWGKAIQKAIRRSMGLPPSSEDNGEIEKIEGLELGDAGYTRLPLHDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WKY2</accession>
    <name>A0A162WKY2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_173123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286745.1">
        <property type="nucleotide sequence ID" value="XM_018436944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WKY2"/>
    <dbReference type="STRING" id="763407.A0A162WKY2"/>
    <dbReference type="GeneID" id="28997850"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_173123"/>
    <dbReference type="InParanoid" id="A0A162WKY2"/>
    <dbReference type="OrthoDB" id="2272068at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052560">
        <property type="entry name" value="RdDP_mobile_element"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688:SF2">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="378"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD68705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="754" mass="83633" checksum="BE4E492D027711F4" modified="2016-07-06" version="1">MSTLLPSSVMQGMSPDLASFLRNMQAQFMSLQQRTNELESLAATNARLTTQLVNAEKLIADLRSQLASQGNCQITTNASTSSAPTTPKEPGTEASTWATTAAAAHNSVVVPTALSVCKTPRPPSVRQVAASARMFAIPTGPKGYQYVYIPRSRRLTHREVRNSLKTLGVDTGRILDINFPAKDVVGILVHNQYAEKFQTTLTTVAIEILDAFDPLDPKNIADPKYKSLSDSELEEVAAELHSDRCMKALKYLRPHVAVPVGHFFCDQGWISKEDIPVHSVSGPGAGLWNANGLQPRAIYDVLQHCHSLHMLFITETWLLPPSRLPTSWSQIHLYGSPVAGNYRGSMGVSVLISPSCPYPVTQIPMSSNYALAIKIGSLRIVCLYLPPSMSTHDALAVLSSIPLTNDTIICGDFNSRLGSLTGDYATNTRGLALCQWLEERALTVVNGQLSPCIPTFISFRQNVEISSIIDLFITNMSLTNATLNIHTDLSLNSDHRLLSLSFTYAINPTSHAPPPSRKTWNLSRLQEPDVLKLYAHTFVTNSINLKSTLQSTFEHPPSSHPPIDALTDEFNSLIYNSLILQAAAEHRNFCYKKWRRACGIDRIHWWDKHLKAQAEFRHQVQSSKRQSWHAFCKSMEQDFSKATSKIKQLKRQWQPQHMFQHSDGPATAATIMCEHLASVYSGSILPDQRPPPPLHSTSLPFTSANSPFVSSVVEGCVQFMPNHKTPGPDHIRAEMLKPCRRVNSCRELKLNDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WTB7</accession>
    <name>A0A162WTB7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Golgi phospho protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_114819</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288865.1">
        <property type="nucleotide sequence ID" value="XM_018428416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WTB7"/>
    <dbReference type="STRING" id="763407.A0A162WTB7"/>
    <dbReference type="GeneID" id="28989322"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_114819"/>
    <dbReference type="InParanoid" id="A0A162WTB7"/>
    <dbReference type="OrthoDB" id="2189106at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031985">
        <property type="term" value="C:Golgi cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3630.10:FF:000004">
        <property type="entry name" value="Probable VPS74-protein involved in protein-vacuolar targeting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704:SF2">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 3 HOMOLOG SAURON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="TRANS-GOLGI PROTEIN GMX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD70825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="31379" checksum="C46C695CF6A154E3" modified="2016-07-06" version="1">MPRLTLLEEVLLLGLKDEQGHLSFWNDHISYVLRGCILLELALRGRIAMVKDPNRRHFELCERMIEVINDRNTGEMLLDETLKLMKASEPMSVQTWIDLLSGETWNVLKLGYQLKQVRERLAKGLVDKGILRTEKRNFLLFDMATHPLADRHCKEALLDRVCSSLVSRHSSPPNGTDIDKVYGYLRTTTMVCSAYAANVLENALMTLDYESREKAYAKVDELLADFSVWPLTGSGAQLQIPDGKALSFEVIPAVLSVFTKMDSIVSLIYIIWVCEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XGA6</accession>
    <name>A0A162XGA6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_180920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292735.1">
        <property type="nucleotide sequence ID" value="XM_018438383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XGA6"/>
    <dbReference type="STRING" id="763407.A0A162XGA6"/>
    <dbReference type="GeneID" id="28999289"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_180920"/>
    <dbReference type="InParanoid" id="A0A162XGA6"/>
    <dbReference type="OrthoDB" id="79367at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CID" evidence="5">
        <location>
            <begin position="2"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="785"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="150"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="268"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="530"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="629"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="712"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="749"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="915"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1016"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="542"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="633"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="761"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="933"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1037"/>
            <end position="1072"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD74695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1087" mass="120986" checksum="590B6C792444C051" modified="2016-07-06" version="1">MTHSFDPAVFEHELYSIYHSRLPVSASKIITLQDLAMAHAQHSTSIIRSIIKFMKKSHPEYRLSGFYVINAISRMAAKMARKDPSRREGLENYLKSFSILFRNDVFKGAFSNCTTTEKEKVIKVLDIWNETKIYHPDDIAHLKQTLFHKSSSLNPNRPSESSANNSTADSMVTSPVIEKRAPQASPEKRTLSISPPRGDESVESSEPVSVAVPLTIAQLMSKLAAAPSEATAKLLAEALQRAHWKMDIDSAINPEETAIQPETWEKTPISDHIASPPHASQSSQPSSLQTHEEYDYDGPKTPPIEDDEDENDDHNGGDYDDIEGQGAHTMQIEMQTEAQNQENKHVNQCYKNEFGNQESSIRRNQREFENSPQQNHTTGHLEANSENYIEAHGSRIKHEEDDQAIIPMEIDNDGPKTPPYLPEDDDKEDAENVEHEEQHHIQNTYKEYPAHPSSASYGVVENNGVHGLTHPQEQNVIEKDRNHSQLLDTSIQEQPIQPSDADILAKWTPMYPKTAAPVEKDTRTSWLDLPQFQGRPKEPAGSSILSPSSQLRTSSSLSPSYASSFSKQIESFVESCFERNASDSPKPYPIYPGIDTLGIQSHLRMSPSVQQSSPTKDVDASVIPEPPIAAIPSSSISSSRTNNNISSTSGTRSTRGISGISGISGISGIRGIRGISGINGIGGNSGISGTSGSNTLDQSALLLEPLILPESTTTDIDNHRQKNSELPPTGPRAFLKRGALQTPIVPEQFHKASSKVNASKPKNKPAKPKNKPAKPVKKRLPVVSRTVFVRPLATTTSKEDLRKAMEKYGVVTSLTTVKAKGTIISGFVRYSRREEAVKAVNSKVETGPNGEKVKLSWARTFGPSRGVVDATNGISIVELENVQRDEMHALRNSDIGGFGTHIVRDQYVVEEPETNYIYKGPHNTEPPSSLRSRLGRINRSRSRSRSRSTNRSTSTNRSRNRSRSTSRDIIADTSPNINISRTRSRVRACSPSSQPREGLSDKLEYNRNLSSERYLMHSPNSYHSRDRSPPSSYGVRSMRRSRSPRSRSPRRRPRSRSPRSRSPRRRPPRRRPISPYYEKNPIKKPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XJT8</accession>
    <name>A0A162XJT8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA helicase Pif1-like 2B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_64279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293395.1">
        <property type="nucleotide sequence ID" value="XM_018441267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XJT8"/>
    <dbReference type="GeneID" id="29002173"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64279"/>
    <dbReference type="InParanoid" id="A0A162XJT8"/>
    <dbReference type="OrthoDB" id="1920387at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="1">
        <location>
            <begin position="70"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="127" mass="14481" checksum="7F7625AF70FE5309" modified="2016-07-06" version="1">MDTADHAYEQIPFGGKVIAFGVIRITDMLSQINEVALKMFPRDDRVYTYLDTAIYSNDPDVDNSRYPFEFDNFLICSKNLLDILKLKVDMSLMITREIDPKAGVCNGTKGVCFPSHMVHISIKRLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XM51</accession>
    <name>A0A162XM51_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_143923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293715.1">
        <property type="nucleotide sequence ID" value="XM_018431100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XM51"/>
    <dbReference type="GeneID" id="28992006"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143923"/>
    <dbReference type="InParanoid" id="A0A162XM51"/>
    <dbReference type="OrthoDB" id="2404451at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="435" mass="49591" checksum="DD820C3976A6196B" modified="2016-07-06" version="1">MSVEDMFSQMLADLATRELLHYRANWESVAGQLTNIFDSDIYKQLVQQSLFSNSNNIAIGFYTNRYTNKYLLQLAILLGLKKPTHLDSFLISIINELQADMAHIGSHTSLFGCHFCETKGKCPANRQHDMYFDNISALLRSLEDFKVGNSSKNIYQLSLYTQLSTFSGSSFFVLDELYLIARGIEKLVADLVAIRNCITSSEKYVPISSLDSFVNVFVKIDSTCTVDWLDFLLYLVSTLVTLTPELLEKMESAKLPGSYTLYHQAARPSAMLLHSLNEESNWRLLKIDKLWGPFHQFVNLNNDLMEGVGGPSVKEALLKYYWRTTGLTGHNFCDSVVIVAARLWMNSTIYSSYMYQRKRNEISRGNYYVMFTCLYRNNLNVMKEHDAAGRDLSVPIVKQCSQSIYIPGHQTQPTYAVISVNDICHQVCLVQYLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XPT9</accession>
    <name>A0A162XPT9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_59579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294085.1">
        <property type="nucleotide sequence ID" value="XM_018440522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XPT9"/>
    <dbReference type="GeneID" id="29001428"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_59579"/>
    <dbReference type="InParanoid" id="A0A162XPT9"/>
    <dbReference type="OrthoDB" id="10679528at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="231" mass="26558" checksum="B19B878A06D84972" modified="2016-07-06" version="1">MGNHDNVDIFDKIDWRVNRVDNEMEYNCKRLACPYLHDYTIPPLYDQKCKYVGSCTQPGYRCRYTLQKQPSDFVSKILITKDNKGKEADEIPATEKEAYTTEKEIFVVKKNRYTEKNERNPTGEEAIYVRDKTLCTKDILVSTVEKSGSPIEKAESTEEKTLSISGRVEHTGKRVKVITQDTEPARKKIKAIAQKTKHILKEPRSTVKKTRLTRKTAKSITEVSNFTGRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XV89</accession>
    <name>A0A162XV89_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_165187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294705.1">
        <property type="nucleotide sequence ID" value="XM_018435177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XV89"/>
    <dbReference type="STRING" id="763407.A0A162XV89"/>
    <dbReference type="GeneID" id="28996083"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165187"/>
    <dbReference type="InParanoid" id="A0A162XV89"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051948">
        <property type="entry name" value="Hsp70_co-chaperone_J-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD76665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="122" mass="13793" checksum="07665A90A078EE2F" modified="2016-07-06" version="1">MVKSPYEVLGVSPSSSPKEIKRRYLELCKKHHPDVNTDPKVKFVDITGAYESLTKPTAPSRPSPGMNAHLTRQWTRRSLVACLGLGLATVAYVVYEPSIDLIDVPYQPPPSPNMNYRQWRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y1Y0</accession>
    <name>A0A162Y1Y0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_164805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295965.1">
        <property type="nucleotide sequence ID" value="XM_018435080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y1Y0"/>
    <dbReference type="GeneID" id="28995986"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164805"/>
    <dbReference type="InParanoid" id="A0A162Y1Y0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="122" mass="13653" checksum="C7719B1564722BA6" modified="2016-07-06" version="1">MFFYMSKRIKSMTPSSLSPHYAAQSPSGRKPDLVAKEVLEWWQTNGKHPFIQPHISSPSNVGANSPENLPLGDKVQLIRLPVASPSAVKEFSQVSSEEPAHLTTVAIFNWKRNEILETLLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y2H9</accession>
    <name>A0A162Y2H9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_40545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD78015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296055.1">
        <property type="nucleotide sequence ID" value="XM_018440147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y2H9"/>
    <dbReference type="FunCoup" id="A0A162Y2H9">
        <property type="interactions" value="1042"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162Y2H9"/>
    <dbReference type="GeneID" id="29001053"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_40545"/>
    <dbReference type="InParanoid" id="A0A162Y2H9"/>
    <dbReference type="OrthoDB" id="435593at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057941">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058537">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF53">
        <property type="entry name" value="MRNA TRANSPORT REGULATOR MTR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24138">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24139">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="1">
        <location>
            <begin position="28"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="941" mass="106988" checksum="54BDB9FCA38018BA" modified="2016-07-06" version="1">MSDVAVSQVLEALSALYSSSNSQAKKEASRWLEDFQKQPEAWTVANYLLTMENSNTETRLFAAQTLRQKITYDLRELNPEARRSLRDSLVQLLWVSATGSKAIMVQLCLAVADLAIQFMEWNTVVQDLIAKFGKTPESATCLLEFLKVLAEEMTSNKRIPLSDKDAQARSALLIEGNVPTVMRLLEMYIQSTGNLKIQEEVFQCLSSWLRTGDVDIRLLETSPLLAAAFEGLSNEELFDVSVDVVCEIIYETKDVTEYRSLIERIYPLFGTLIQQLREAKADEDSDKVRGYCRMFVEAGEAYVLLIAQHPESFGVLLQGISECTAYEDLDIVPMTFKFWYELTNTLSTESYKPAIPALVGYYDSLVDSIIRHLHYSDDVEEMSAKDRDDFRDFRHQMGDTLKDCCRIMTPQKCLLKPLTLLTRLLTQAETPPTWQQIEAPIFSLRSMGSEVPSDENEVMPQIMEFLSKLPDHPKIRYAATLVISRYSFWTRLHPEYVTYQLNYISAGFENQEVAAASALALKHLCKDCSELLIDFVGQLHPFYINIVRTLPFNDIIEVTEAVSHVISVIPASEILNALKSFCLPIAQDLHSIVAKNKNTITQNEIAKAGDLLEQIAIFFEIIRPEDIPVGAPHPCVAFLNELWPVFDMCLSNFGSEPIIAEPLCRCFRNCIQSYKLHFAPLLPLLMERLVGGFDSSRLGVYLWVAHKLVREYAIEGTESVTVCFQLLESLSATVFTTLNEKKFEEIPDVVEEYFRLTSAFLDCAPTLFVQSQLISPVFQAGLAGLSLEEVRALTAIISFYRHLLSIDLTTSELEKPDTPLTASTLTLNTERIISLFREFGGDFVRLLFDGMIHHYSWEMIPDVAATMKSLAQLMPVESAQWMVAVVNGFPEQHMSASERTEFLQDWTRQVYIAIQEKQWVKVRRVLSDFVSQYRRRNTNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZDR1</accession>
    <name>A0A162ZDR1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_152890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441006">
        <property type="protein sequence ID" value="OAD66091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284131.1">
        <property type="nucleotide sequence ID" value="XM_018433021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZDR1"/>
    <dbReference type="GeneID" id="28993927"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152890"/>
    <dbReference type="InParanoid" id="A0A162ZDR1"/>
    <dbReference type="OrthoDB" id="2282145at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="189" mass="21543" checksum="4D8767F33DA8706D" modified="2016-07-06" version="1">MTISNIRNHPYAFEHALQLSPDYTQPSPAATRQKQTAYCTWLVFMHPNWVPFDYNNHYKLEQTLSLGGTFVDIQDSHFPCVKRVRVFPKSNYLSYLGVKYRLSRVMQPDAWIDPPDHEELLLLSSSSSSNNNASSNSSLEDNDLDDYRMPPPLHFEGLSSLASISLYSDNQSTDDSNLFRSLSISSRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZL21</accession>
    <name>A0A162ZL21_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Copper fist DNA-binding transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_118415</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285571.1">
        <property type="nucleotide sequence ID" value="XM_018428631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZL21"/>
    <dbReference type="STRING" id="763407.A0A162ZL21"/>
    <dbReference type="GeneID" id="28989537"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_118415"/>
    <dbReference type="InParanoid" id="A0A162ZL21"/>
    <dbReference type="OrthoDB" id="5600085at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD67531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="55" mass="6395" checksum="E45850616C6A7938" modified="2016-07-06" version="1" fragment="single">KGHRASHCNHVDRPLIEIKKKGRPMTQCQKCRELRVVRQLHVKCNCADTTGKKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZL55</accession>
    <name>A0A162ZL55_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_189028</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285591.1">
        <property type="nucleotide sequence ID" value="XM_018439601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZL55"/>
    <dbReference type="STRING" id="763407.A0A162ZL55"/>
    <dbReference type="GeneID" id="29000507"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_189028"/>
    <dbReference type="InParanoid" id="A0A162ZL55"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24119">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24119:SF0">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACB" evidence="5">
        <location>
            <begin position="6"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="189"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD67551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="220" mass="24853" checksum="1F1BC562B545366D" modified="2016-07-06" version="1" fragment="single">MESAQLDDWFESAYIYLSTHEKISISNDNKLKLYALFKQVIIGDCNGPKPNLFEFVARAKWDAWKSIYGMPANEAKEGYVSFVESLKVGWSRAGEYKYEGVDEETRGFGTSVSTLSYDTEEIVEEDLFSLTCAGDVEKVRERVTKYNDSVNSKDDEGLTPLHHACDRGFPDMAEALIELGANINAQANTLETPLHYAYISEQLETAKILHNHQCDISLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZLV8</accession>
    <name>A0A162ZLV8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Stress-associated endoplasmic reticulum protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_151228</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Interacts with target proteins during translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation and facilitate correct glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the RAMP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285741.1">
        <property type="nucleotide sequence ID" value="XM_018432631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZLV8"/>
    <dbReference type="STRING" id="763407.A0A162ZLV8"/>
    <dbReference type="GeneID" id="28993537"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151228"/>
    <dbReference type="InParanoid" id="A0A162ZLV8"/>
    <dbReference type="OrthoDB" id="16679at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010580">
        <property type="entry name" value="ER_stress-assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06624">
        <property type="entry name" value="RAMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD67701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="130" mass="14733" checksum="C78B7121563D03D8" modified="2016-07-06" version="1">MSKRDYHFLQSKKPGWANEKFLFLLAQLGFFDLNGYAVNIANQRLPRSRTVAYINESTHSVSPTYLSKATVPTLRQKNAAYQSNVNKRGHVKTSLKPKNKFKIPITYWAMALIAFTFLGGALVQVLNLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZQD7</accession>
    <name>A0A162ZQD7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type zinc finger transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_150541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286401.1">
        <property type="nucleotide sequence ID" value="XM_018432497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZQD7"/>
    <dbReference type="STRING" id="763407.A0A162ZQD7"/>
    <dbReference type="GeneID" id="28993403"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150541"/>
    <dbReference type="InParanoid" id="A0A162ZQD7"/>
    <dbReference type="OrthoDB" id="2262863at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="723" mass="81590" checksum="7829954C41E4D4E6" modified="2016-07-06" version="1">MQRIINYPKNSRVVVSAPKGPGQHNFAFDDIGKTCSLCGKDFDCVWNLRRHLTKYRKLATHIANDISPQYANRNLASQRQTTNTAEPTAPDHNDNSVNEDLHVESDLEDDDSSDVDDMNSDGNDNVSEIELDAGESIIEMDEDTSPFESPSPGNLLYMHIRNSMLSSASNISSSLDADLDLLREATGSHMTWNQYTSDTHLFPDLQSIVLLAFVDGDNDMVSCRILKKILFTISLVLKLHEEAIQKKSLFKLPRLDALLNYQTRKKSKIPVFPSTKVDIQLPENNTTSAYINLPSDHVRFLAANPKKARNMFSLPDRTPNQSICLQQDEKWRTHWYYQQPMLTHNSVDFWSGDIVNFMNGSIPARFLVESFHTMDNSAVFVQGYMVYILEGGQLISIEVESTSIKLETLLGVDSTPVDVALCYSVSPGKVFHLISRHKSLLEEPHFLKRHVLDETGKPIDPKLFYKVRILPIIHFTNNTSRNRSKQYNPYKSWSMKFTALSYEERSSIENIHFLSAIPKKKGASGMSLLPKIVEDFKRLKNKLVMFSAKDNENVLVASPLLWIEADTPCHSELCGLRAPTSLYPCCKCYVRLQRSMPNLQSFSYYTGRHTARTKAHYLAAASTSERGSTIPDAPLTGNALTASDLCFTNRATDALLELQSFDPSTDTPVEVLHNILLGVAKYLVNDLVKVVLKKNPNQMARLSKALKDYENSQGMSRKFTQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AGI7</accession>
    <name>A0A163AGI7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HotDog ACOT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_168689</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291371.1">
        <property type="nucleotide sequence ID" value="XM_018435919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AGI7"/>
    <dbReference type="STRING" id="763407.A0A163AGI7"/>
    <dbReference type="GeneID" id="28996825"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168689"/>
    <dbReference type="InParanoid" id="A0A163AGI7"/>
    <dbReference type="OrthoDB" id="331699at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655:SF0">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="89"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="319"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD73331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="487" mass="54574" checksum="B228F21584FC8166" modified="2016-07-06" version="1">MLSSLKNTPKNIKFYRFNSINKKNWIDTKVTSISAKCNGSNFANNSKERVVLAEPIKFWAEEMNLKGNQRPLVAFDKFESKHDFVMMDSYTEKTLPFKSSPSFLEKTITHNGKISIGYLLQISDEIAYVVGTKHLDIHSCLHRIPSHVLTASVEHAHFILPDTIQDIRLSGHIVNVGTSSIEVLVKAKIIPCADKPLGARMELKDSTIDYITAPTSNTVFLAKFNMVAVHIETGKAVKTNSLVTTNVGERKMQELANVMKNKSYISNKDIKTSTDGKPETSKGSNNIVADAFDKKKNSMGEYKLIRDTTLQSAFIVAPQPTKLREIRLILDNCLYLQDRSVLGYLFGGKTLNYVHNIAYITARMFAGSNVRMCSLDEATFHSKVDIGSTVKLTAQVIYSSEDDNMFQVKVVSSLYDFNGALDDKEAITANFTFLSLDKKIKNLVPMTLKENGLYIEERGRILHSMSGKRFLDLTMLLLGSNTLPIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AUQ2</accession>
    <name>A0A163AUQ2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_59468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293981.1">
        <property type="nucleotide sequence ID" value="XM_018440499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AUQ2"/>
    <dbReference type="GeneID" id="29001405"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_59468"/>
    <dbReference type="InParanoid" id="A0A163AUQ2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="115" mass="13530" checksum="7BAFC1BA8EF00CBA" modified="2016-07-06" version="1">MQKTNIDSIKNLNKAILGNIILRRRIFTNILVSFLGYPAIYIGWMREKDILNQLRDDGMIFDELTRVNQIKSTVRPREYVLADHLVRQKQAYKKKKQKRLTFQGVLSPAIPKIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B5F0</accession>
    <name>A0A163B5F0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_140468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296411.1">
        <property type="nucleotide sequence ID" value="XM_018430405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B5F0"/>
    <dbReference type="GeneID" id="28991311"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_140468"/>
    <dbReference type="InParanoid" id="A0A163B5F0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="135" mass="15012" checksum="C941C0EB56F83E1C" modified="2016-07-06" version="1">MTTNMTSSGLIVESVDLVVEKFKISDVIEIASTPNKDYATRGSTNLSKWYDFEIKSEENHPTSPELASLIWVADTSTDGHHSTNALSHKSGMDSKRMVAIYNKQETGRLGKDMTNSFSRSTKSKTLEIYGSKWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B7D3</accession>
    <name>A0A163B7D3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavoprotein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_77081</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296691.1">
        <property type="nucleotide sequence ID" value="XM_018443225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B7D3"/>
    <dbReference type="STRING" id="763407.A0A163B7D3"/>
    <dbReference type="GeneID" id="29004131"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_77081"/>
    <dbReference type="InParanoid" id="A0A163B7D3"/>
    <dbReference type="OrthoDB" id="1532798at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1950:FF:000004">
        <property type="entry name" value="Phosphopantothenoylcysteine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="3">
        <location>
            <begin position="6"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD78651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="191" mass="21135" checksum="25A3EF3ED3654936" modified="2016-07-06" version="1">MSSQINILIGTTGSVASIKLSELVLNLKQNPRVNVKVVPTKASSFFFKEKDIDAQIHTDEEEWAIWKKKTDPVLHIDLRNWADIMLIAPLDANTLAKIANGLCDNLLTCILRAWDIKKPVVVCPAMNTNMWNHPFTAQHLNILQDVLHFKVIPPISKLLACGDLGIGAMEEPGVIASTVMTILLDSQSDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BBX9</accession>
    <name>A0A163BBX9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DDT transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_75547</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297581.1">
        <property type="nucleotide sequence ID" value="XM_018443069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BBX9"/>
    <dbReference type="STRING" id="763407.A0A163BBX9"/>
    <dbReference type="GeneID" id="29003975"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_75547"/>
    <dbReference type="InParanoid" id="A0A163BBX9"/>
    <dbReference type="OrthoDB" id="332390at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013136">
        <property type="entry name" value="WSTF_Acf1_Cbp146"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075:SF6">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02791">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10537">
        <property type="entry name" value="WAC_Acf1_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00571">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51136">
        <property type="entry name" value="WAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAC" evidence="7">
        <location>
            <begin position="26"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="DDT" evidence="6">
        <location>
            <begin position="333"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="414"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="596"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="555"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="607"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="625"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD79541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="897" mass="104032" checksum="C18A8A0384E65BFA" modified="2016-07-06" version="1">MPLLKRKRYPLLQPPTVDPTKKDKERPVWYYKITNEVFEDYATYLQRLSLYKRPVWQCETTGRSNLTYEDALKSEKTERDRVQDKLPEELQQRVLERVQFQTARLDTVVEDVYSYFLERYIAGEIVNCLWDDGIVYNARILEVLPSDKQDEDESKDKGNSYKVQLIDDHLEGIDDFIKVVTKSELKRDRLSYSKNLLKNFIRRYTIKETYVGAPWLVKPGLAEKYGIESTLPQSLQEAKNNAYLKSRKRKTGTPEELTPKKPEEKPLDAKKLEAMIKYPMEDLDVPIYRRDPSGEGPIMDMSPSTSNSTKTIQNPTGGMPICPTPCRDSTIPTECFGSFLMVWCFLSIFARPLDLSPFTLDDFENALHHNSTYIKSQILIESNVALLNAIIRQQRKSKLQGVASKNLALYDEHTSRSTTPALDGQSKDSSTRGSQDGSDEEKDELVGWPAQRALSRRASLVERGCGSDEIMRIGTGWDSATIKSVNDREGWEDVLIGCINQLAPSEKVPEFDRILNSLVPRHNSTLEERQTAYVSLCLKDKIMIFELLVQTVNECAFIKEYMEECQDQLTELRKQKIELSRERKRIYAARLEYEKRTGEHSGKTNEETENDASDDDSESSDTEDDVSKAQRQFKNETIHESRQAILKRRQQEREEREAKKLKLHHRQREEARARNLELKARAEERKKIDEEERQLHRKEEQVERDMRKYSTLRIKPLGRDKFFNRYYYLDHIGGAAAHGTGRLCVQSPSETDNMLLMERDQPSMDEKLTLPCGRGGGVGFVCQLMKEQGLPEESKLLEKSLDSQPLCPNLNEWWWFYQEPEELDALLAWLNPKGIREYRLKRELEKHIYSLTAGMKKRNNEHMTAKIVDVPRRSTRSKIAPQIPSGSWLAYVNKYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BGU8</accession>
    <name>A0A163BGU8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_72594</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299541.1">
        <property type="nucleotide sequence ID" value="XM_018442683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BGU8"/>
    <dbReference type="GeneID" id="29003589"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_72594"/>
    <dbReference type="InParanoid" id="A0A163BGU8"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD81501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="154" mass="18207" checksum="58E77602F780812C" modified="2016-07-06" version="1">MSLNSGLPTGRYERVEPSSRRIFMAHHRCHRLLQLPQDLLKATMKVLSNEYGLFQDYDHHPETLQQQVQYNLTSVVIRQYDPRNPLSQNTRASSPSSTNMHRCPECPYETDKKSNFDRHTKTHSGDRRLFCCPKCPKKYTKNYNLKRHINQRNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163CTN2</accession>
    <name>A0A163CTN2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_103719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441010">
        <property type="protein sequence ID" value="OAD65530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283570.1">
        <property type="nucleotide sequence ID" value="XM_018427782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163CTN2"/>
    <dbReference type="STRING" id="763407.A0A163CTN2"/>
    <dbReference type="GeneID" id="28988688"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_103719"/>
    <dbReference type="InParanoid" id="A0A163CTN2"/>
    <dbReference type="OrthoDB" id="2505730at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="52" mass="6127" checksum="3A86913293C1D8B6" modified="2016-07-06" version="1" fragment="single">AVPIFHAYVHVQHCQVKLNPKYRDGFGLTDGECLERLWSYLNRFVTMTRKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163CYD1</accession>
    <name>A0A163CYD1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHYBLDRAFT_137244</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441002">
        <property type="protein sequence ID" value="OAD66500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284540.1">
        <property type="nucleotide sequence ID" value="XM_018429846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163CYD1"/>
    <dbReference type="FunCoup" id="A0A163CYD1">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163CYD1"/>
    <dbReference type="GeneID" id="28990752"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_137244"/>
    <dbReference type="InParanoid" id="A0A163CYD1"/>
    <dbReference type="OrthoDB" id="387657at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="14">
        <location>
            <begin position="9"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAD66500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="474" mass="53052" checksum="928E62CC196FEF41" modified="2016-07-06" version="1">MSINDLSVLTLNCWGLYFIAKQRKTRLRAIADALSNENHDIVTLQEIWMLEDFEYLKSKVENVLPFSNYYYSGALGSGLAILSRFPIVSTSYFRYTLAGRPLKIFHGDYYVGKGCASACINHPDIGIIEVFTTHLHAGYGDVDEYEGHRVTESWELSNLLRASAAQGRQVIATGDFNSIPTSYNYALLKKHAFMTDAWLEAHSERLSQTGLDPGHRSPHECIQHLGITCDSPANTWSKHFLKQQPHSKQVGDRLDYIFYRRTSQITCTGSVVAMTDYIPGTQMCYSDHFAVQATFSINSQPTQVNSTSPSAVQLSNPSFTTFPLSIAQAVLTLLRRDQVATRKTAYRLLLLFGVALIMLLFLCVSTVAVLPDWIAPKDESQLKFLLGSLASSLVMIISAVIATICVVVGFVFGHTEERALRQFIEEIQLLVASIQEDSRSDAPFVHLSNQASDNPSRETFYNEFNERTRLLDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163CYL0</accession>
    <name>A0A163CYL0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor PAP1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_95550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441002">
        <property type="protein sequence ID" value="OAD66550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284590.1">
        <property type="nucleotide sequence ID" value="XM_018443915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163CYL0"/>
    <dbReference type="STRING" id="763407.A0A163CYL0"/>
    <dbReference type="GeneID" id="29004820"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_95550"/>
    <dbReference type="InParanoid" id="A0A163CYL0"/>
    <dbReference type="OrthoDB" id="2593073at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.100">
        <property type="entry name" value="YAP1 redox domain. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013910">
        <property type="entry name" value="TF_PAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023167">
        <property type="entry name" value="Yap1_redox_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08601">
        <property type="entry name" value="PAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111430">
        <property type="entry name" value="YAP1 redox domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor PAP1" evidence="3">
        <location>
            <begin position="3"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD66550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="51" mass="5897" checksum="8B1CD8162E133543" modified="2016-07-06" version="1" fragment="single">LVPCSTAWKRMSSHPRFEAFNLDDLCDQLKRKAKCSENGPVFEEEEIDIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DIK2</accession>
    <name>A0A163DIK2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit DUO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein DUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PHYBLDRAFT_72069</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DUO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289520.1">
        <property type="nucleotide sequence ID" value="XM_018442590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DIK2"/>
    <dbReference type="STRING" id="763407.A0A163DIK2"/>
    <dbReference type="GeneID" id="29003496"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_72069"/>
    <dbReference type="InParanoid" id="A0A163DIK2"/>
    <dbReference type="OrthoDB" id="5599235at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013960">
        <property type="entry name" value="DASH_Duo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08651">
        <property type="entry name" value="DASH_Duo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="117"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OAD71480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="209" mass="23913" checksum="7AB1C337030A7C98" modified="2016-07-06" version="1">MNQDESNAKSREDSSNHALRKNNLLPSDRRATLLYRTMDHTQPPVEDPSNPPHINTQRRHEYEAIKGINRVMGQVIENFGKSSTHIKELAETVNESEQLLDRWIAVLSQTEHTKRLLEDPDWHGKEAEDQAKSRETSSPTKKRPIEKTGMNNILKMDKLSYIEPSRSQNRKKPTPSTSATRNSRLSQGSKQVSFKRTSFGEGSLVKKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DNV1</accession>
    <name>A0A163DNV1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_102238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290630.1">
        <property type="nucleotide sequence ID" value="XM_018427693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DNV1"/>
    <dbReference type="GeneID" id="28988599"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_102238"/>
    <dbReference type="InParanoid" id="A0A163DNV1"/>
    <dbReference type="OrthoDB" id="3039677at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="177" mass="20130" checksum="A6822D27201DE4DE" modified="2016-07-06" version="1" fragment="single">NLPRSERFKAENTILVGLMPGPKEPKSEEINHYLKPLVDKMIQLYLGIQIPTYQQTDGATVRAALLMVACDIPAARKTSGFTAHNSTCACYKCDNQFSRLPGTSSVDFRGFDCDQWRHRSDRANRVHAEEWNSASTPSERQQLEVEYGVRWSQLYCLGYFDLVRGTIIDPMHNLFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163E9Z4</accession>
    <name>A0A163E9Z4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="8">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_131217</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eIF-5A family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295610.1">
        <property type="nucleotide sequence ID" value="XM_018429413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163E9Z4"/>
    <dbReference type="FunCoup" id="A0A163E9Z4">
        <property type="interactions" value="499"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163E9Z4"/>
    <dbReference type="GeneID" id="28990319"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_131217"/>
    <dbReference type="InParanoid" id="A0A163E9Z4"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006452">
        <property type="term" value="P:translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0385">Hypusine</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="9">
        <location>
            <begin position="85"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD77570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="157" mass="16858" checksum="7B55DE0B54190E8F" modified="2016-07-06" version="1">MSDDHDHTFESAGAGASLTYPLQCSALRKGGHVVIKGRPCKIVDMSTSKTGKHGHAKVHLVAIDIFTQKKLEDLSPSTHNMDVPNVTRMEYQLINVDDGFLNLMTADGTSKDDVKVPSGDIGAALEADFEEGKDLLVSVVSAMGEEQALSYKEAPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167J6F0</accession>
    <name>A0A167J6F0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_153661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441011">
        <property type="protein sequence ID" value="OAD65269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283309.1">
        <property type="nucleotide sequence ID" value="XM_018433217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167J6F0"/>
    <dbReference type="GeneID" id="28994123"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153661"/>
    <dbReference type="InParanoid" id="A0A167J6F0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="289" mass="32972" checksum="AA90D9B88EA1C762" modified="2016-07-06" version="1">MQFVESACHIYSQPSLLLLGRSTFLITLILSRMQRVLHVTIAHIKFFDKLGSIMRQFLHQKILPMASLASLCFPWTQDELGILNPQFQIPTKSLYQAMVKALYISTSVLLLFHSTDTTQSSSCPNTRRYSTTFVVSTSATPSFFVLSTMKPIPRNFSFVTVGYFIFVILLDLEAVRPRSPNERNSSPYLISKLTLGTHSFCAICRNPFKALLASLPLTPRQWCTFWSFPIPHSSDNIWYRTILNTLSFQITLYHHASALFDTVVYTPQLSEVHTRRPNTGYLLLMNLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167J6N8</accession>
    <name>A0A167J6N8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_153542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441029">
        <property type="protein sequence ID" value="OAD65299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283339.1">
        <property type="nucleotide sequence ID" value="XM_018433180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167J6N8"/>
    <dbReference type="GeneID" id="28994086"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153542"/>
    <dbReference type="InParanoid" id="A0A167J6N8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22475" checksum="932F42F61DEBB8AE" modified="2016-07-06" version="1">MNNTDNNSISLLHAMYNEILSLKAGQEKVKLEMKAQIEELKLEMKTSIEDLNLEITALQSQLENRNISNQHTSPSVSAISSANTIHKPVSIFREITLKHIFKMISEDLGIEVTSNEKATLNMCTKLICDDMAAHPSVIALGPNPSWGSIPVALKKEMCARHANIMKDSGIDFTRCLGNWVSTARVAHLWRDRHKRLQSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167J770</accession>
    <name>A0A167J770_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_71056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441029">
        <property type="protein sequence ID" value="OAD65349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283389.1">
        <property type="nucleotide sequence ID" value="XM_018442401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167J770"/>
    <dbReference type="GeneID" id="29003307"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71056"/>
    <dbReference type="InParanoid" id="A0A167J770"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="230" mass="25719" checksum="56758CA8788DDBCE" modified="2016-07-06" version="1">MFIFTKSIVNIKVHCVPQENTLLLNMLRSKTNRSNKSNNSTSTNGYESAEQISPSNVGELLDLMEQRTRVPSSAPMAPSPKRARTNNENDPSESTHTIEDVYQKIDQVSTFLLSSAQNVASNTIATIASEVVENVLAPGRISTVDDYMFNESLYSQYNGSETCRSDGNRQIIQSTSKRRLFAFASKKEYFVKTFGEDSNILLQADYTSDLDSDNDNDSGSSSCFWQFWPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JLH8</accession>
    <name>A0A167JLH8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_189333</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441004">
        <property type="protein sequence ID" value="OAD66256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284296.1">
        <property type="nucleotide sequence ID" value="XM_018439646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JLH8"/>
    <dbReference type="STRING" id="763407.A0A167JLH8"/>
    <dbReference type="GeneID" id="29000552"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_189333"/>
    <dbReference type="InParanoid" id="A0A167JLH8"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="220"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD66256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="322" mass="37053" checksum="0F0D2813651A2A8E" modified="2016-07-06" version="1">MEISEIVHQESLPTDERPFECTFADCNKTFSRRSDLVRHSRIHTNERPFQCRETGCHKSFIQRSALTVHIRTHSGERPHECEFPECVKSFSDSSSLARHRRTHTGKRPYRCPSEGCSKSFVRKTMLTKHMKCDHSTNGKRPHVQWRPFNEERRRVQQIQHQQVQETQQEEEEEVEVESYATKHNQPNDQSDQNCIMACACSGSYSHFGHSWTAFETLNPRTPPLSTGRASPSFSSDDQSMPSSPSSPLSWTQNPWSPIVHSTQQPSLPPPSALLSQRPYSHRPTLDLPVFPHDTILPRLDCLQFQSQSDELTDLPSQNSFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K080</accession>
    <name>A0A167K080_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHYBLDRAFT_57829</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD67008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285048.1">
        <property type="nucleotide sequence ID" value="XM_018440257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K080"/>
    <dbReference type="FunCoup" id="A0A167K080">
        <property type="interactions" value="269"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167K080"/>
    <dbReference type="GeneID" id="29001163"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_57829"/>
    <dbReference type="InParanoid" id="A0A167K080"/>
    <dbReference type="OrthoDB" id="9805536at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.150.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004039">
        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="46"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="169"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="399"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAD67008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="529" mass="57376" checksum="8557B401C6EAA8CA" modified="2016-07-06" version="1">MLRNAARVARPALAVFSKATPAPSTAEVSSILEQRILGASAEADLQETGRVLSIGDGIARVYGLKNVQAEEMVEFSSGLKGMALNLEADNVGIVVFGNDRLIKEGDTVKRTGAIVDVPVGPGILGRVVDALGNPIDGKGPLETVGRSRVQVKAPGILPRHSVNEPMQTGIKSVDSMVPIGRGQRELIIGDRQTGKTAVALDTILNQKNWNNGSDESKKLYCIYVAVGQKRSTVAQLVRTLEENDAMKYTIVVAATASEAAPLQYLAPFSGAAFGEWFRDNGRHSLIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNKAFGYGSMTALPIIETQGGDVSAYIPTNVISITDGQIFLEAELFFKGVRPAINVGLSVSRVGSAAQTKAMKQVAGSLKLFLAQYREVAAFAQFGSDLDASTQFLLNRGARLTELLKQPQYTPLSIEVQVPIVFAGVNGFLDKLPVGKVVDWEKDFVSYVKTQHQAELDEIRTKGVISKELDAKLRNICETHVKTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K1Z6</accession>
    <name>A0A167K1Z6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_74109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441025">
        <property type="protein sequence ID" value="OAD67096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285136.1">
        <property type="nucleotide sequence ID" value="XM_018442981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K1Z6"/>
    <dbReference type="GeneID" id="29003887"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_74109"/>
    <dbReference type="InParanoid" id="A0A167K1Z6"/>
    <dbReference type="OrthoDB" id="2300438at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33324">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33324:SF2">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="192" mass="21841" checksum="FD009D83CBC694C0" modified="2016-07-06" version="1" fragment="single">MSNSNSEISLSTEDNHAIKNEYKTWYKHDGGKDGLTSMERLQQFMLMNGGENLNMYLGGDKEGRTFKSSKVTILNKCNQYFQEQGVYRTTAQIKSRLNNLLTKQYGEAYRVWKNSIKNNSNDEGSTSEKEGLESELNQICPAFFQMEKVMSNRKTGSPAVCDTTKPMEWIHDEDGEQSNGDDDNTDEESAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KE48</accession>
    <name>A0A167KE48_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor IIIC putative zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_188883</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285919.1">
        <property type="nucleotide sequence ID" value="XM_018439576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KE48"/>
    <dbReference type="STRING" id="763407.A0A167KE48"/>
    <dbReference type="GeneID" id="29000482"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_188883"/>
    <dbReference type="InParanoid" id="A0A167KE48"/>
    <dbReference type="OrthoDB" id="6021743at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044230">
        <property type="entry name" value="GTF3C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024761">
        <property type="entry name" value="TFIIIC_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024764">
        <property type="entry name" value="TFIIIC_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12657">
        <property type="entry name" value="TFIIIC_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12660">
        <property type="entry name" value="zf-TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor IIIC 90kDa subunit N-terminal" evidence="2">
        <location>
            <begin position="21"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC putative zinc-finger" evidence="3">
        <location>
            <begin position="716"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD67879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="821" mass="92917" checksum="D16DD3D59D56E7B2" modified="2016-07-06" version="1">MEVQPGIVLQSKPFFSNCVSWSEDCHILACFESAVHVLTPILAGMASDLEGHIHEGILAIDLEPSEFGESQVFEQYVDPSYAMPESFRWATWSPSGLSSSLGCYLTAVTTKHRIVFYEHPDNGQSRWIPTLDLTKDIYKHVKSTDESAMDIDEKAAALAPSDEEDDEEEEDDEEENESSDDQKESNPKKLNSQFQFKNIDEMKRFQTLYCAWTSKIIVDPLAEMPGVLALSHKSGHVTIWRALKEKGKHSYSRRHGLAFITEFRPTNNYVNLLQWSKWKISGNTYTAYLMASSNSGEVYLSSFTITVNADAKGQVHIYSPIVKKLFTWFKDSPSIPILLTTWDDFSDDGSTLKLVVSKGISILTAFLKIESDSAEMIGDWHRYIPEDTSMGLSSASWTTDGEYLQAFTHEGQGLVLNTKESTISLNLPRSCALTDILLHKYKFQCMEIESKAEEDAINPNIDIVPIMWGTANSYSSLYTAIAFTMKPVIDISNRSNSVFDTYMGFILQSTREETETLEMLCKNIEKCIKDPNYIFTYPIKNIIHEALEYVANDESVDTIFTWLSTVGSLMKDTHRKPRDPNTLTKNIYSDTTSAAAMTMCTVKLVLKYFELPKMINEDLRKWCAMARKITRENYADSVLQFAIEREDEDFREFDEDDIMVIQLICDDALIEGNVSSYLLDTIRNVHDKLESCFPDLGPYDDLLAEIDRASQFSKTTEPSEKVIGREHCPICQDMIMPSRGTFASCTSGHTWEKCCMTMRVLSTPSARKCTSCNSKSLQPGSLDFIRLPNNNPEHMSFTDTILLKCQKCIFCGSDLIDINAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KQX9</accession>
    <name>A0A167KQX9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein 198</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_63426</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM198 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286708.1">
        <property type="nucleotide sequence ID" value="XM_018441117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KQX9"/>
    <dbReference type="GeneID" id="29002023"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63426"/>
    <dbReference type="InParanoid" id="A0A167KQX9"/>
    <dbReference type="OrthoDB" id="102260at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040236">
        <property type="entry name" value="TMEM198"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31247:SF5">
        <property type="entry name" value="DUF4203 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31247">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 198 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007889508" description="Transmembrane protein 198" evidence="9">
        <location>
            <begin position="26"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="10">
        <location>
            <begin position="133"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD68668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="360" mass="40008" checksum="8E48347509F7362E" modified="2016-07-06" version="1">MYIRYPKSFFIILLLCLTISTQCVAQEVNQIHANHYHTPTPTHTHTTNCQSHRTHSQSHTPSATAAPVRKQETYECISSQNRCFPRVITVVKNLKNTPVEKSRSGHLLCPIVTEKPNLPELTEEMIYDIAIGSTFITFGVFLIVLAFPFFIVTMAICGTIFGGNTTFIIMSYMEPLEGYENPLMMYTSICFGVGLLFGVAAVVFWKVALFGLGFTAGFVLAVYVWTFSFDFIITDTNARLFASISVGMLGGVGIVLIEFLAVILSTTFLGSYLVMLGVDIIVNFGMVSGPCQVFNYNTHLEEKIMSGLYVEYFPSDTIYEMLGGMFGLWLLGAFLGIKLNQGSRFGLQLKKNPILDLDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KST5</accession>
    <name>A0A167KST5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_117270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286836.1">
        <property type="nucleotide sequence ID" value="XM_018428571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KST5"/>
    <dbReference type="GeneID" id="28989477"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_117270"/>
    <dbReference type="InParanoid" id="A0A167KST5"/>
    <dbReference type="OrthoDB" id="2439011at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="230" mass="26357" checksum="92A4A43768DEBCF1" modified="2016-07-06" version="1" fragment="single">NLPREERNKAENVILVGLMPGPKEASTDEINNYLRPLVDELMLLYKGITIDTYNCSGALVRVALLMVACDIPAARKTCGFTSHNSTCACYKCNRQFACVDGTTAVNYFGLKFSEWVGRTKEENCRHANLWKNAKTLTERKRLEIENGVCWSELHRLVYFEPVRATIIDPMHNLFLGTAKRMMDIWIANNLLDDKDFVEMQEEANRMVLPVGYTTLKIKIGKKFLFMKAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L1C5</accession>
    <name>A0A167L1C5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHYBLDRAFT_135934</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287407.1">
        <property type="nucleotide sequence ID" value="XM_018429755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L1C5"/>
    <dbReference type="FunCoup" id="A0A167L1C5">
        <property type="interactions" value="160"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167L1C5"/>
    <dbReference type="GeneID" id="28990661"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_135934"/>
    <dbReference type="InParanoid" id="A0A167L1C5"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097435">
        <property type="term" value="P:supramolecular fiber organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BETATUBULIN"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
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    <keyword evidence="5 12" id="KW-0493">Microtubule</keyword>
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            <end position="244"/>
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            <end position="383"/>
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    <sequence length="450" mass="50783" checksum="5BF310458E67787F" modified="2016-07-06" version="1">MREIIHVQVGQCGNQIGQKFWETISQEHGLDTNGNYCGDNDLQLERINVFYNEGQKGQYVPRAVLADLEPATMDVLRGSLYGKLFRPDNFINGQSGAGNSWARGYYTEGAELIEPILDIVRKEAEHTDCLQGFQLCHSLGGGTGSGLGSLLLSKIREEYPDRMLCTYSVVPSPKVSDTVVEPYNAVLSVHQLVENCDATFCIDNEALYDICFRTLKLTNPGYDELNQLVSAVMSGVSTSLRFPGQLNSDLRKLFVNMVPFPRLHFFMVGFAPLTAFGSQQYRNLSVPELTAQMFDARNMMAASDPRHGRYLTVATIFRGRLSTKEVENQMLAVQQKNSSYFVEWIPNGVKTSLCDIPPVGLKMSGTFIGNSTAIQELFKRVNEQFTVMFRRKAFLHWYTSEGMDEMEFTEAESNMNDLVSEYQQYQEATAEDDLLDEEEYLEEEGELDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L9C2</accession>
    <name>A0A167L9C2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium-channel protein CCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PHYBLDRAFT_182669</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
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        <property type="protein sequence ID" value="OAD69889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018438657.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="4"/>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
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        <property type="entry name" value="Ion_trans_dom"/>
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        <property type="entry name" value="VDCC_alpha-1_subunit"/>
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    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
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        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
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            <end position="388"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
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            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00067459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OAD69889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="2102" mass="240516" checksum="B5CF52C46D6E0ED2" modified="2016-07-06" version="1">MPDSGIIPTESEPKSNRASPQTPLSDASSVNVPQITLTTAQAEDVIEFIHHSPNQQQPSSHLSTPLPLTRDLLRRKNKIDKLLHHNPHNLSTPNTYVVDERVTAGLGIATPHDNLVLGGTGLRSRRNSNRITSSTDDEKLWYKSQPSSPRVSDYSHFQWTSTLDRFKDSPNANSSCKDNKLSGTSSVTSMSDNASMKAYNAEAHRYMEYSYDQSRKLRHINHHHYHHHHHNHPVRKRRSQMQQYLDLIYEAAARVINSRSPENKKKKYTIEPWKETYLSPPSSPPQHQPPSTTAPAPVTVTATAAAREAFDEKNTSDIQRPLDLNDPIDNLPKESKENQLQGYSLNLFSPTNTIRLWLWKLVKSKNIEVLLLLLLLLHWFLMACVPIKNNDEKSIFGKQWTHYPILCIQSIYSLEAIAKIIVYGFWIPPTREKSRLSMIFTPISNCIRRLRGLSRNLHDNDQKEEEDKIELEHKAYLNKFGNILDLTSIVCYWIDFGFMLHGYRYFTLFKTLGATRPLRLLLIFPGTAMIVRSLEESLGLLLVVLGFLFFFLLLWALIGLISFQGVFSRRCYVLDSAGVSTYVEPPAYCSGFYNGTELIGPYNVIRETYGFPGPQGNICKSGQICIEDPINNPNFGFVNYDTIFYSFLSIYTVQTLEGWTPMMYQNQDGDSNAVAVYYCICVYVLSFLVTFLVFAVITSTFTQIRANNYGSGFKAKKKSYPLLRLADSHENSTHEDIPWMFEDAHKDSGIGVTRIWFKRNVVNMVKSPKFFYFGGLLVFLDLVFMCMRSFYATEKTLEIIDNAETTFTFIFVIEIVLRFVGAPNWIQFWSSGRNRFDLFLVISTCVIQLPMIQDSEAYKYLTIFQVLRLYRLLICFPRVRRIIYASLGNGESITNIVIFLVLATSLCSPIFMQMLGGDFVDFMDADSTELRFDAFWQSFMTLIMLYTSETWTQLLYNAMESQNGLGSIYAAIFTCIYFAFARFILAGLYIAVILENFELEEEYIKQYQIKRFIRQHTHKDIHKAETILNKLFGSLYKRSENRSVQIPRMPTSLTVPVSKSSLAELLVDHDDPDLKEGEAAVLAEEAKTAEKDEHAKKKSGHGHVYTSTAFADITIEDATDDYELIVAEENRRALQSNIHERKSLFIFSQRSKTRYFCKRLVGNNNDGKSERKNLFNWFIMACVALSIMMVILDEPSTRKLREDSMAQSAFYIIDYILSLIFVIEIIIRVIADGLFLAPRSYLRNAWNTLDFTVVIFNIITIFLGSERSPRALSTVRSLRILRVIRYFKGVRDIFVDLFHAFPLMLDALVLTFLVLVPYSVYGINIFGGRFWLCNDDGMENIAECLGEFANNISGDDVVDANILIPRVWQNPETNSYSFDNFPQAFNHLLGLTSTEGWVDSLFSAMSTPSEEGQQPSFSWDSPMIYHSIYYITFMIISHGTVQLFVGVIIEKFKQRSGITTLTLKQRQYLDLRRQMAEIKPTIKAYRPDSVIRGWCYDIVANKRGIFNRITMGVVITNIAIICTEYQNAPTWLEQLQEYAYTACIIIYALEVLVKFLGMGRKKWAATKWNWYDGFIAISAVLLLILRFAVPDLWTLRVERYFLVFAAFRLGEGIDVLQKLYHTVANSMPSIIHVSVVFLIVMCLFAMLFMELFGLTRYGPNGDEHGNFRTYGNALLLLVRMTTGEGWVVQYPNCVNFADYLETDCGSPGWSFFLFNFFYIVCTHIFLNLFTAVIISNFEHTYETRSRFTGISKNDLRTFKHAWAEIDPTGTGYIQKKDVTKLLHHIRGHLQLGIYDDAYSIKNLKKLSNIQVNEDEQHVLDDKIDKPGTPSYIPGRVTHGYNYNEVNNCLSKINPQELQARRKQYNLYYREIIEAERSKGISFADVLTIITYRFIDVEESLTLEPLIARLEKLERLEKAYAVEKASGVFMTLIQRKRYLHQIWLKRNEEEIKKLGVASAGSLHLDTSVASLSTPGTRDVRQHSPVPRIIVENVHLSSPVNHQSTPISPMSNFSMDTQQGSPFAGLDSPGTISGAPSPSPYDEESSFFGTPSPGLSPHPNLSPYARHGWLMMDGNNSMSEEQAGRLMESFYNNTWSDMLDAAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LFA7</accession>
    <name>A0A167LFA7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_86166</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288367.1">
        <property type="nucleotide sequence ID" value="XM_018443638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LFA7"/>
    <dbReference type="FunCoup" id="A0A167LFA7">
        <property type="interactions" value="483"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167LFA7"/>
    <dbReference type="GeneID" id="29004543"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_86166"/>
    <dbReference type="InParanoid" id="A0A167LFA7"/>
    <dbReference type="OrthoDB" id="120967at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PXA" evidence="5">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="315"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="4">
        <location>
            <begin position="660"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="536"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="556"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD70327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1019" mass="117986" checksum="D8D0B0411A8BE578" modified="2016-07-06" version="1" fragment="single">IAEAFEELLSYVLRDFVDFWFVHLSGSIEEKSFPSAVDHIIRTALLNLKGRLEDKDLMSIVLNRLMPIITLHISEFREAEVSLRGRSLERSVTQSDELDLLLASQFRGGKLHPALTTAAVTTKPTEIAYLRQVIDRIMPYIFDKKDIQSNAVALIIREMATCAVLQPTFDMLADPDFWNQTIDIYFSAAFLGTGLEEAWDEQEEDADTKRIFGFGSTKMGRQTFQDFLKMIESEKNLLDLKRVRNDIITQIRKKKALTFEDVNAYVNRLSVAKKRVDKRIALLSGENYEKRSPTSQLFGSRKQSTTFTSQTTGYTLYDILTNTAGLSYFMEFMDRRGDMVKLQFWLIVEGFKNYDTSDNSPQKRDEKTFFQDIKMVHEMYFADASPHRLPISENLSRDLMDAIQRAQIDLIEENESVFSETVQEMGRRLYRIQQSIFWQIEKEHFLYFKRSDLYFKYLATSPNSAPDTLPERHEYTQNKSISTLPRREGSIKITKPQSFQRPSPLILYGTRGIKSSMAMPVQNDYTLPSWKSSGGTNTISEVEHDQIGPLTPRGSIKSQEQQEIHSSASSTKAPSGDNVHLAPPGDLLLASKVKQISEDVKKLMQEEALVDALIRKSEARNEVESLRLLRKIKSACRQDIQQMKYQKSQYELQESENVLERTKVSITNSTIGSDIHGEFALYVIEIHQLGTEGNYTSGWIVTRRYSEFFTLHQKLKDHYAAVKMLDFPVKWPLLKLQRSFVETRRISLERYLRRLLEDKLICQSDELRVFLSQQNVYVPGPKDNSDVDYEFAGFMKHIYKTVAAGFDDMFIGPSMLDLITQRLGEQVMEFSYESDMNDPNSTFPHSHSLSNSFGNVELSNEALKPVENEGITRFTEPLCDLFIEMFELKEKNNWLRRQAVVIILQQIFGGTIERKLRESMRFLESEPMILFYFRRLTDTLWPEGASLSFKPPRRPEEKQHTREEANRKLSTWLPDLLGSMVGRQNSRRGARRLFSVLQNKRLNQDLVYTLFDEILYELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LFB6</accession>
    <name>A0A167LFB6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">deoxyhypusine synthase</fullName>
            <ecNumber evidence="6">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_135415</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="6"/>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288368.1">
        <property type="nucleotide sequence ID" value="XM_018429717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LFB6"/>
    <dbReference type="FunCoup" id="A0A167LFB6">
        <property type="interactions" value="665"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167LFB6"/>
    <dbReference type="GeneID" id="28990623"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_135415"/>
    <dbReference type="InParanoid" id="A0A167LFB6"/>
    <dbReference type="OrthoDB" id="294378at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000001">
        <property type="entry name" value="Probable deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD70328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="367" mass="40522" checksum="5C3D6BDDE2E06F8F" modified="2016-07-06" version="1">MSQTPNEPSQPTGAQAAVFVQSVAMPESAVLIKGPDFNQNLSLSDLMSSYKTMGFQASGLGEAIDIINCMRTWRLSDEPVAADETEDYRDPETRCKTKCKIFLGYTSNLVSSGMREIIKFLVQHKMVDVVVATGGGIEEDFIKCLAPTYLGAFDLKGSDLRKQGLNRIGNLLVPNNNYCKFEDWVVPILDKMLDEQKTKGTIWTPSSMIKKLGEEINDESSIYYWCAKNDIPVYCPAITDGSLGDMIYFHSYKNPGLIVDIAADIRSMNNEAVFAKKTGMIILGGGLIKHHICNANLMRNGADYAVYINTAQEYDGSDAGARPDEAVSWGKIRLDARSVKIYAEATLVFPLIVAETFAKGHHEVKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M9N8</accession>
    <name>A0A167M9N8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHYBLDRAFT_177777</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290249.1">
        <property type="nucleotide sequence ID" value="XM_018437926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M9N8"/>
    <dbReference type="FunCoup" id="A0A167M9N8">
        <property type="interactions" value="515"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167M9N8"/>
    <dbReference type="GeneID" id="28998832"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_177777"/>
    <dbReference type="InParanoid" id="A0A167M9N8"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007890212" description="dolichyl-phosphate beta-glucosyltransferase" evidence="13">
        <location>
            <begin position="17"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="34"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAD72209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="291" mass="32680" checksum="94A7A227516E1D67" modified="2016-07-06" version="1">MTLYLYWSAASLTVLAATVSNSSSLFDEPTVKLSCIVPAFDESKRLPTMLKETTEYLENKRLENSENTYEIIIVDDGSRDNTVEVALEFAKESNPENIRILVLEKNRGKGGAVTQGVLCARGERCLMVDADGATRFSDLEKLQDALDNEAKNGRGVAVGSRSHLVTTEAVVKRSFIRNFLMRGFHTLVYVLGIRGIDDTQCGFKLFTRGAAQIIFPNMHVERWIFDIECLMIAQQQNIPIIEVQVNWHEIDGSKVNLMVDSVQMAKDLLLIRLNYLLGLWTVDTNTAKKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MBX9</accession>
    <name>A0A167MBX9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_146606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290454.1">
        <property type="nucleotide sequence ID" value="XM_018431683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MBX9"/>
    <dbReference type="GeneID" id="28992589"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146606"/>
    <dbReference type="InParanoid" id="A0A167MBX9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="305" mass="34121" checksum="9ABC1B58D5918506" modified="2016-07-06" version="1">MPSNATRKSGRKGKQNARGTLSHVAASRIEQCEIAPRVSPLAAGPSGAEAPGMTVESLTQVMAAINMIYNCIVEANTRIRFLVDAHNQAIAQQALVASSVTQGVTAANVSTNRHTKGEMHAIVLNLINGRMWARNFRSDDPELVAENESHRQWNTDERIDHPDNVEVINYLRQYIIVQPRTAGFWEDMIVQKIKNNYEACFRAVNATPEQASSKRRNNPIDTEMGYKPGNPDEMAYLHLLEKSVMSDGELEDEDVTPIIRVQVLQVACPSWRSAELNRLIQFIDFLAAENDKKIAISQSKQRMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MDT1</accession>
    <name>A0A167MDT1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_65393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290604.1">
        <property type="nucleotide sequence ID" value="XM_018441445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MDT1"/>
    <dbReference type="GeneID" id="29002351"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65393"/>
    <dbReference type="InParanoid" id="A0A167MDT1"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="628" mass="73676" checksum="68D2B1E89F2054CE" modified="2016-07-06" version="1">MLASELPFEILLNISRFLHTKDKFHCMFICRAWKIPFQESMWRKVCILDKKKLEAICSTSAIKDNIYLNGHNTRDLYLNGKIRATDSQLYALQLCFQNLRRLYIKRNCLNETDFGKQADWNLWKYLEDLCIVLDELRIEDTEKVFLDIVSCLPRLKRLDLIRHSWKTKLAFTMKDFETLHKHLPRLEYLTLSVDLGSLSREELLQARTVDPATNLTVFKVDTKIADHRWLYYFAQKYPNIHTLRWEPYDKNGVTDDYQEETSFLLKGVRYAFQRLKTLNVHSAGSSDWLHLFFWKILCPSSLQIRNISCRPYLQTRKPEILEEIIRMCMDSFSRTVETLSIKGRYRFNIPHKLTELFVYSPHLVYLNIDQSDASIILDELLDRCVVLKRLRFACGWISVSPDSHNSLGRHGLRMIEIYDSTIDTDTFDYLSFHCRHLNYLSLTDIKAIGKVSPKTGSLCLNMSYSSFEILHIFGIQLYPSEDNINPNTVVNIMVFSRPIPGNKKPENDTSNATVFGSKQSKIFTESTWFHLYCDEKDMDKGAHTTRIMRKKEVNQARKYYRHFQRNKSAAKKLDDIRSIDGQTTRYGWKKDLPRGYAVLKCGDVAKYVIGSELTDAEIFWKNIFDSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MID4</accession>
    <name>A0A167MID4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor ISY1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_187241</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ISY1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290964.1">
        <property type="nucleotide sequence ID" value="XM_018439353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MID4"/>
    <dbReference type="FunCoup" id="A0A167MID4">
        <property type="interactions" value="643"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167MID4"/>
    <dbReference type="GeneID" id="29000259"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_187241"/>
    <dbReference type="InParanoid" id="A0A167MID4"/>
    <dbReference type="OrthoDB" id="1739576at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000001">
        <property type="entry name" value="pre-mRNA-splicing factor ISY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="195"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD72924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="31506" checksum="0457217E269A053C" modified="2016-07-06" version="1">MRAKERNSSARNEEKAQSMLYRFREAQAAELGLIRKKERRPGMASTVTSVGECERWRREVLGDVSRKVSKIQDVSLSDYQVRDLNDEINKLMREKYHWERRIRDLGGADYTRSAPKMLDHEGKEVPGNRGYKYFGRARDLPGVRELFEQEAPEPASRSRSEIYRNIDADYYGYRDEEDGALVEYEAEQEQDLAERALRAAEEQEKKEEDDEKEKAEELEQLRSESAVPDQKDIEAYLVNRRRQQLLDKYVSEDLQQNEQETKELTGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MWQ0</accession>
    <name>A0A167MWQ0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_167720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292344.1">
        <property type="nucleotide sequence ID" value="XM_018435698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MWQ0"/>
    <dbReference type="GeneID" id="28996604"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167720"/>
    <dbReference type="InParanoid" id="A0A167MWQ0"/>
    <dbReference type="OrthoDB" id="2290028at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="30546" checksum="EB4536BBE8853134" modified="2016-07-06" version="1">MNNNNNNNTSIDSSAEILRLLAFIINSRRNANLTNVELLLNQISKQDLILQQQIERSRQQLLDCAANIMIESLQLVSCDYFFMIYTCRSHSFTLERGPQEVNHVRYGVFRQWWYVRHPTLTDDLGSNSFQLQYQMSRANFELLLNIVSQHQVYEAVLNNNSYPIEIQVATVLWRFANTHFGYHLTEQFLGVSAGSYTRFTMRFITAMSDYSDKFVNWGVHDSETAARRAAEFEQPERRGVRLPGVIGAIDGKLISIQKPSLHGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N7R7</accession>
    <name>A0A167N7R7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3020 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_143512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293294.1">
        <property type="nucleotide sequence ID" value="XM_018430998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N7R7"/>
    <dbReference type="STRING" id="763407.A0A167N7R7"/>
    <dbReference type="GeneID" id="28991904"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143512"/>
    <dbReference type="InParanoid" id="A0A167N7R7"/>
    <dbReference type="OrthoDB" id="5595797at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021386">
        <property type="entry name" value="SPP41_DUF3020"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11223">
        <property type="entry name" value="DUF3020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3020" evidence="2">
        <location>
            <begin position="146"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD75254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="387" mass="43099" checksum="DCFB9DCFAE2A770C" modified="2016-07-06" version="1">MRSDAPFTPGVPHEIEKTVITSQSTETPSSPDKNTTPAPENQILSSPAPSNSDLTNLNLNSAHLQHMDAAQAQAIAQAAAAAMAAHGSHYHQLFTSFDPNTTQHITDNSSTVLATSLATDFIKRELINQKVNHSFLPEPYEVRADNRDRKKRWRALNEERNKDNDLRCRVNKRANKLFGKDDIGPKRHWVEEEFVKRQAKRKEKERRKRVVDGTVAHTPTDYGLDITAATQQLTPQQLQILQETNYLSLICSNLGALSPNTASKLLGVEQGSTNPQDKTQHLSSQLIEFLQQLQQYQPPQTVESSVPQPSGTPTLNTAVQDTRPEEKVAALLSSSISSIATAVESQDKDKKDFEEQDHVSASPEQPRIDYPMDAVLTLMQLNSGWRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N929</accession>
    <name>A0A167N929_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_166626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293419.1">
        <property type="nucleotide sequence ID" value="XM_018435448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N929"/>
    <dbReference type="STRING" id="763407.A0A167N929"/>
    <dbReference type="GeneID" id="28996354"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166626"/>
    <dbReference type="InParanoid" id="A0A167N929"/>
    <dbReference type="OrthoDB" id="2389915at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="713" mass="79784" checksum="54A35B9AF2A1B01D" modified="2016-07-06" version="1">MFSITKRSSYKCRFCNTFYNSTRKVNLCRIQYMKTCSSNMVNFEISQPISVSEQTNIVSSIVSGYTSDKENTATIDNQTVDAFNNGDNDNDQPMYDADLDHAMDDIHVKTSPLIFDFSQPTPISNNDDAKNLKFIKIIKDFGILREAHEMIARHFNKILETSNDITYRACSSYLGDKLLERFSSVKGDKYDICHNDCKLYNDSHETVCLNCGEAHYKNDAKDKDGLTLPGTTICIIESFRSFNPDSVLYKGLKGQSPFASLTSFTGPFFFALNEMHGLSHGIGKQVWGLVCRKYGSKHPLFLSAGAQKKIDVAIEGTRESIPTSFHGAWREVARHAEYFRAVNWANFLLFVVPTLVAERIHNQDAQKALLGLVQACTLLMSWDVIQSFVFGTYSDLSLRNLIKWNSYLEGHFQNGKVGIEIFTINQHLLQHYPAMINAFGPPRAYSARSLERAIGEYSRSIKSNSAIGANAGNIMLRLACTRCVDVNGALVVKARATARILQYNDESAGWPMTEEGERVDVDSDIEFWGPLEYKTIHDSIEEISCLPVLLAKFHESKGVECSTIDSALTTSRKAFVNGCVIDSVFAHKVQREAHHIHLQLQINKATNARSGSSPALKHFFGKVVLFFEHVNEGKRWPLTLVLVYSTMLYNGVPVARNGQMKPKVVHLVDVKELVGLVVSDATVNTITAMTTAYIVWPELNRGPKLSLGSFADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N990</accession>
    <name>A0A167N990_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_64311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293430.1">
        <property type="nucleotide sequence ID" value="XM_018441280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N990"/>
    <dbReference type="GeneID" id="29002186"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64311"/>
    <dbReference type="InParanoid" id="A0A167N990"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="101" mass="11169" checksum="2FAC38609DFF1C89" modified="2016-07-06" version="1">MEGVTQALGAAVSYYSILFGSNGISGLYINAPMHRITVPLGCSICQYFFIPLFLYPLAEIVSWKLFFFAVVYGSQIAVCDGTLNNKPLYPETLNAKMYLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N9S4</accession>
    <name>A0A167N9S4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_110931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293469.1">
        <property type="nucleotide sequence ID" value="XM_018428186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N9S4"/>
    <dbReference type="STRING" id="763407.A0A167N9S4"/>
    <dbReference type="GeneID" id="28989092"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_110931"/>
    <dbReference type="InParanoid" id="A0A167N9S4"/>
    <dbReference type="OrthoDB" id="434647at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071782">
        <property type="term" value="C:endoplasmic reticulum tubular network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF117">
        <property type="entry name" value="LP05237P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="145" mass="17227" checksum="5EE96E1CE55AF6FE" modified="2016-07-06" version="1">MLFGGIYFIVKLLFLQLYPAYICYKAIKVNDPNQFGPLLTYWVVASGFLVAEYLTDIFLFWVPFYTDIKFVLLLWLILPQTQGTLVVYRDWLDPFLSQHEEYIDKTLIDIQTKARQTISLHLQTLLYTLRNVIIDIIKVRERKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NKW7</accession>
    <name>A0A167NKW7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_166134</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294200.1">
        <property type="nucleotide sequence ID" value="XM_018435369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NKW7"/>
    <dbReference type="FunCoup" id="A0A167NKW7">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167NKW7"/>
    <dbReference type="GeneID" id="28996275"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166134"/>
    <dbReference type="InParanoid" id="A0A167NKW7"/>
    <dbReference type="OrthoDB" id="10248252at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF21">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4 WD40 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="680"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="902"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="37"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="234"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="380"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD76160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="972" mass="108026" checksum="3E9CB76763725CA6" modified="2016-07-06" version="1">MENEGAYVGLFESVFNRYMSIRGRFSDGRQTAISDKKVPETLNLGHDTRNYPSTTSQSNLSNIPPTTITQTDSPEFQPETVYISSDDEDDMPLFHDAVLNIDPVTEFQGSSMMNPISLDSETEEEDEDIDPRTEEELLAERRLVAERFNKNLVILKEAGMDVTISDPHEYTYTSSNQSETEVSVPSIPSLSLLSSPNNQLSSTKTSFQTDDSSSDLIIGGMFMNLDSDIECINIDDDDDGNADSTSIDDDGDEALPANNADSHNANINIMEVESSIETEENQSSSDESGEWEYGERTPDPIPINTDSSNMDFTYQYDSDLTPNTTEEPDWSYVKSLNDNTKEWVRPSRDILPCRPRTRFPPRTSSFEMLEMINVYIESLGPLDSSTSQTGTRAASKATRSTRRQTTLKPVSRQSSLSSIQRVKPYVPYYAWYNSNWEDWAQFEHGDIIHWPFSEYERDIVRSMIEPGERFRRRLSTVDWVTMSVNLPGRTSADCQRYWIDHQEEIHGFHPHPIMITRKKARDLKKPTYRLLKERELSTTFLPVPLEVAGWCNLQTSRTFGDGSGDVFSLGILQNPRSHVLTVVAGSTCDSQAEYNRPGNLRLWRESSEEVQHLPCHNTPITLPDRTTQDLWASVSDVKISVDQTLIFSAAFDNRAMVWSSDTGAFLSKLGNSYICARTLIEYHTQRINQISVKRDIKENVLATGSEDGDAVIWSVDKTGTKGTGSSCILDYPNLVKPSIECLEFGHFASDNILFTGVRNDHLLLPGLVQSFDVNTADILELYTFGESYKGGAISALAICPDAETTLGKSFATGNYGAAEGTLGDGNLYIHDCRITTPVIVAPTAHIDVNVVAYSPCLNYVASGNATNEIAIIDVRSPEKPLYRLSHAPSTRSRGVYEADIGISGVHWLSNGRTLITSGGDGMVRLWDILANGTLLKTYQAKNDITSLAVNEEAMVIVAGVSGSGGVVHVWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NZG9</accession>
    <name>A0A167NZG9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GATA-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_104333</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294986.1">
        <property type="nucleotide sequence ID" value="XM_018427838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NZG9"/>
    <dbReference type="STRING" id="763407.A0A167NZG9"/>
    <dbReference type="GeneID" id="28988744"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_104333"/>
    <dbReference type="InParanoid" id="A0A167NZG9"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF335">
        <property type="entry name" value="IRON-SENSING TRANSCRIPTIONAL REPRESSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD76946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="52" mass="6227" checksum="B200643F46A23079" modified="2016-07-06" version="1" fragment="single">VQCTNCQQTQTPLWRKNDRGEPLCNACGLYAKLHQKDRPVEMRKTTIQRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P4K8</accession>
    <name>A0A167P4K8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_165725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295276.1">
        <property type="nucleotide sequence ID" value="XM_018435291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P4K8"/>
    <dbReference type="GeneID" id="28996197"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165725"/>
    <dbReference type="InParanoid" id="A0A167P4K8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="207" mass="24177" checksum="21E5854F793CB9E8" modified="2016-07-06" version="1">MCNFCSFHQNKNRFCDERKYLFNTEFEDDEHLFQAYARKQPVWQQVATRFLITPTFLTFEDLLLPTSPLSVKDIPFVTSRIAAIATLNIRRLELEESIQTYNLYRIENRSTTPFFFNTQKSKSQAFLALSKILQINKALMLFPIESNKHCLSTPTEKLIHTMKSPKRYLHLSDILYGHLIQNAGSVPKKDPVRSTTCVHPTHYKKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P526</accession>
    <name>A0A167P526_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_122270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the GSE complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295301.1">
        <property type="nucleotide sequence ID" value="XM_018428863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P526"/>
    <dbReference type="FunCoup" id="A0A167P526">
        <property type="interactions" value="438"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167P526"/>
    <dbReference type="GeneID" id="28989769"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_122270"/>
    <dbReference type="InParanoid" id="A0A167P526"/>
    <dbReference type="OrthoDB" id="26136at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11385">
        <property type="entry name" value="RagC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000643">
        <property type="entry name" value="Small monomeric GTPase (Gtr2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039400">
        <property type="entry name" value="RagC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="269"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD77261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="406" mass="45853" checksum="D3BB6442DD268C52" modified="2016-07-06" version="1">MDYDYLHNNDSEIADTVDDQVSSDKPRILLMGLQRSGKSSIQRVVFGKMPPNDTLYLESTIKIQKEDITRSFIDFQIWDFPGQVNYFDMTYDSQEIFGTVGALIFVIDAQDDYGEALHRLFYTVTGAFRVNPSITFEVLIHKVDGLSDDYKIDTQRDIQQRMGDALADAQMEHIHLTYYLTSIYDHSIYEAFSKIIQKLIRELPTLENLLNVLCSNSGIDKAYLFDTLTKIYIATDSSPVDMPSYELCSDMIDVVIDIECIYGVADRTQSSSPEIGMDDTRLDGRELMQSPTSGGSSMDRGSRGGGASEGSSSDAAQHNRAPSPMEAEASSLIKLDNGDVLYMREVNRLLVLICLLRQDNFEKHGLIDYNFQCFKEAVTEVFEFSQKRNTQQRQLSVTDGQESQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PFI0</accession>
    <name>A0A167PFI0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_60939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295854.1">
        <property type="nucleotide sequence ID" value="XM_018440722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PFI0"/>
    <dbReference type="STRING" id="763407.A0A167PFI0"/>
    <dbReference type="GeneID" id="29001628"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_60939"/>
    <dbReference type="InParanoid" id="A0A167PFI0"/>
    <dbReference type="OrthoDB" id="2262863at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF34">
        <property type="entry name" value="NOTOCHORD-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="571" mass="65336" checksum="63D4404624057345" modified="2016-07-06" version="1">MPLSVLPGNVDRDAVFYKVRIVSIILFTNDTSGNRSKQYNPFESWLMRCAALPFKDRNSIANIQFLSTIPKKDGANGMSLLPAIVDDFKKLEKGVKMFSAEDNEYVLVVAPILWIEADTPCHSELCGLLGPATTFPCRRCYIELRRAKVFVKDLFYFCECHERRTREHYVLANSSPGRDTEIPNAPKIGMNTPANKISFRDRSTGRLLELQSFDPEKDTPVEILHTILLGVAKYMVIDLVKVVLKNDTATIARLSEFLTDYTRSTGLSRKFTRNLRHSGSFLGRDFKVLLQILPVILITEFSGNHELDLIIPCFVELGRLCSLVFVRQVTSDFDNYIIRVDNAVKCLIRALFDYDKGTKNELHKAYCTKPKVYYLTHLKEDIIRFGPALNYETEKGEQFNKHIREHLFHTNRQNTSRDVCLKFAKQVALQHVIDGGSWINSSGNREKSGTGIERFIKDNNESLFYYTFFGGSRELKDNNDTGDIEDDAVQNNSFGAFVFKNDPISRPRIGLVSGSVVKFLSIVPRTDNDRNNNYAKAVMTDLHIFRNPFYIVNLSKFGSYWFIFNNILFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PKA0</accession>
    <name>A0A167PKA0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_141982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD78116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296156.1">
        <property type="nucleotide sequence ID" value="XM_018430718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PKA0"/>
    <dbReference type="GeneID" id="28991624"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141982"/>
    <dbReference type="InParanoid" id="A0A167PKA0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="195" mass="22420" checksum="742A374DECC0DE84" modified="2016-07-06" version="1">MSDINTTLINSVRKIEIDIAEIKQMIRMLQDQFSKQFVLTLSTQDFTLERVGGDFKGENEFQKYNLLLPLLHKQDWKACYKEIPGEQPLPQLVLLLDSNLTIKRLQLKTLSHSIKHDLIDKNFSAFSIEWKGILAKHQEYYMMQLERLAKDNGFAIYKCKSAQQDASDSSLSSDNILETDGGKLPIMVFSGRNEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PMH4</accession>
    <name>A0A167PMH4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_185131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296257.1">
        <property type="nucleotide sequence ID" value="XM_018439036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PMH4"/>
    <dbReference type="STRING" id="763407.A0A167PMH4"/>
    <dbReference type="GeneID" id="28999942"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_185131"/>
    <dbReference type="InParanoid" id="A0A167PMH4"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007891244" description="SH3 domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="318"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="459"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="471"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="508"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD78217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="535" mass="58701" checksum="403260E13068D9FB" modified="2016-07-06" version="1">MIIVTFSLIILIVFLQSILADDSGCVLLQGSRACPAFQQFYVGLPGLSTQYSFIGNATTTESFDQSLFNYVNSTSNYLFPLGCLSSNYNPTVPYARYSLSRLCALMIQDSEDSLPCNYQHNLIPPPLCQQTCDDWVDSIKEITNDPAVCSSSLQRNTTLASLSLQCVSWQGFNGTGDTNCVSGIANEPENCGFQGNVPGACHYCTNHRSDTCCAAVHGCKHPLAPGAIAGIAVGCVVFSLIVLASLLYLCIRKRRTPSHFSSPELGPDHSLERREDVSTSQQALVHSASAGVVPPDLPIHNMPPMEERSTISPVQPLTLNAFHIVVHPYPPQVDDELSLSIGDIVCLALSFDDGWALGFNITSGRKGVFPTVCIAPAPQDLLNRLMLMPENPNSYSKIQWEDTSSNLPDMEEYHIQQRDASNHPQKDAVLTMERLHENLQRSISLGLFSKPIARSSLVYTHTMPSKKTRRTSYSSDSENPTSPSHALYSIPYSASQSTPKDSYELQDHNTSTTNMTSLHPSSHTSNDVRSKRRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QZL0</accession>
    <name>A0A167QZL0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_129204</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298559.1">
        <property type="nucleotide sequence ID" value="XM_018429271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QZL0"/>
    <dbReference type="FunCoup" id="A0A167QZL0">
        <property type="interactions" value="825"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QZL0"/>
    <dbReference type="GeneID" id="28990177"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_129204"/>
    <dbReference type="InParanoid" id="A0A167QZL0"/>
    <dbReference type="OrthoDB" id="331763at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000001">
        <property type="entry name" value="Elongation factor 1-beta 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018940">
        <property type="entry name" value="EF-1_beta_acid_region_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001326">
        <property type="entry name" value="Transl_elong_EF1B_B/D_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF21">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10587">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01182">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00824">
        <property type="entry name" value="EF1BD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00825">
        <property type="entry name" value="EF1BD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="6">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="5">
        <location>
            <begin position="113"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD80519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="22226" checksum="259342E8B758146F" modified="2016-07-06" version="1" fragment="single">MPVTLKRSTILPILEDYLTDKKFIEFDKFTGADGLVAEALGSAPPPEYPHIVAWYKESVKDEKEAEALIEEEDDIDLFGSDDEEVDEEAEKVKAQRLAEYQAKKANKPKTIAKTTITLDVKPWDDETDMEALTKAVKNISMDGLLWGGSQLVPIGFGIKKLQINCVVEDDKVSMDDLSDKITELEDFVQSVDVAAMQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R3Y7</accession>
    <name>A0A167R3Y7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_138347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298834.1">
        <property type="nucleotide sequence ID" value="XM_018429974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R3Y7"/>
    <dbReference type="GeneID" id="28990880"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138347"/>
    <dbReference type="InParanoid" id="A0A167R3Y7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="207" mass="22583" checksum="03AD503D1C80878B" modified="2016-07-06" version="1">MSTQSILISEFSSASTWYCEMVDSLEVGSSVKKQPVAPSQQRRARSVQFSNIVSINNSSNTTVLNESGIGQAQSAYQRNWLLSPVKTHGVVSISTKKNTSYCMIQNVFPMSTQSILISEFSSASTWYCEMVDSLEIGSATAKEPVAPIQQPRARSVRFSDTISITNSSNVIGMDRSEGDQIQSSYHRSIRESTITTTTLPPSSSSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R885</accession>
    <name>A0A167R885_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_138626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299124.1">
        <property type="nucleotide sequence ID" value="XM_018430035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R885"/>
    <dbReference type="GeneID" id="28990941"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138626"/>
    <dbReference type="InParanoid" id="A0A167R885"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="114" mass="13210" checksum="4F93A563CBA77500" modified="2016-07-06" version="1">MPRHKRKRSYWYYKQVHGELGESKLAMVTHSNSTLYAHDGNVGMWLEEVGLLWHYADRWMALARHFSMLGLQMTVSGQIKSNNSNSHTPDALYCHLHGAETKGRLKQLKIWTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167RFA7</accession>
    <name>A0A167RFA7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_65725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299557.1">
        <property type="nucleotide sequence ID" value="XM_018441516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167RFA7"/>
    <dbReference type="GeneID" id="29002422"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65725"/>
    <dbReference type="InParanoid" id="A0A167RFA7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD81517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="424" mass="45224" checksum="708E0BC74145176B" modified="2016-07-06" version="1">MPRFTALTNLSFAAPKRAKASRYQPYPAQSVRCALRASAKSPLGAIGVFATGGFLVTQVTSPEVFGGSGEAQAVPRGTKRPCPEDFISTAHMAKRLEVATVQALRRPAGRGPRGFKLSTSPARRVALKQSLRLVRHVVFELQRRGVISMTGQINDPLPSYCNMSTTSVLAPVPVPVPVSASTSSASSSVSSSASTSASVTPPVRSITRSSSRIVTNSSSGFFSPSPSPSPSPSPPSSLSPSSEPETSLSLFQALSSLESIESSEQSESSSTMALGSTYTKVISIAVDTTQTITSSVVSVVGAIKKFFSWDKDKVKAKVKVKSKVMAKSKSEIETEKGTRKREDGENIIIIIITINIIVINIIINININIIIIIIIIIISIVLHSFCVAHRQRIIYVLKGLSSNTYTFSGQKVFRSQKLSVSSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N2P7</accession>
    <name>A0A162N2P7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_153630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441011">
        <property type="protein sequence ID" value="OAD65244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283284.1">
        <property type="nucleotide sequence ID" value="XM_018433209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N2P7"/>
    <dbReference type="GeneID" id="28994115"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153630"/>
    <dbReference type="InParanoid" id="A0A162N2P7"/>
    <dbReference type="OrthoDB" id="2243238at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="611" mass="73114" checksum="CC5FF2F0D95B3453" modified="2016-07-06" version="1">MATKLPPNILTYLATHVDKKDRLNCAIVCKQWTEPFLNAYWAQVYFSGYMLDKLCDKFDLKEVYQWNAHRTWALNIRLFANDLKYIPVLQQTYSRIKYLKYSIYDEDIFAVKIDWSLWKTLSHLELDFQKVELTIDEFLEQLSPLTCLVHLTICQYIDNINRPDTSLTDMESIHSYFPHLQYININTLFKPISEKEIETIRNVEPAHTVTKIVLYFPYIDPSWIFYFAHKYPNLVTCNLRSRERKPRFYLPPYDQKKYQIQPQLLLSSKQFFPCLQTANIIVHDNNYWLFYLFYDTLQRCNVKIKHATIKFNENMSKENGLNSWIKYLSESVISLNIYSSCCNQSIPVETNPVVLYKNLTVLKILVCPRVDMEIILNYCPVLRSLYITDSMIHSPEYPLSMHAPHPLQRLEIEMAKTSVSVFKYISFRCRQLKYMKLKNIFYKPSDMNETGQILVDMSFSQLKVLKTSESEIDDPEDIYGIISPFFLHIVIEQIGNVGTDQVQAPRSNWYHLCVDKTNRKSRLLAWELGRRDIEFCQRYLKDFKRRKGREKKRKDMKRSEYNYKLKRFWKRDLQHGVLIFRLKSVETYFLYEKDDRNFFLYLEPESEPESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N2Y1</accession>
    <name>A0A162N2Y1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_173871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285998.1">
        <property type="nucleotide sequence ID" value="XM_018437124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N2Y1"/>
    <dbReference type="GeneID" id="28998030"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_173871"/>
    <dbReference type="InParanoid" id="A0A162N2Y1"/>
    <dbReference type="OrthoDB" id="10539329at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="168" mass="19225" checksum="E50EF2FF404EC47F" modified="2016-07-06" version="1">MAHSNVQPVYAAPPVMVEQVQQQPPVAYCAQPTPVYYSPNRMSVVNTPNVVPVAQYGPYPRSFCEPPDCCCFRGQLCKKKTISRTTLPNPNTVRLKTIRVYRILVFLNSVITKLFFLLSLNSLRFGPITTPFSLIFHYVQKTILDHFSFASSPEFMTLTPNTYRWIWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N7Y7</accession>
    <name>A0A162N7Y7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_68756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD71958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289998.1">
        <property type="nucleotide sequence ID" value="XM_018442008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N7Y7"/>
    <dbReference type="STRING" id="763407.A0A162N7Y7"/>
    <dbReference type="GeneID" id="29002914"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_68756"/>
    <dbReference type="InParanoid" id="A0A162N7Y7"/>
    <dbReference type="OrthoDB" id="2379842at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22744">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="30035" checksum="F9790E4E9BE3F1D8" modified="2016-07-06" version="1">MKDKENWVNMYVYKHAHFGNCTLNREESAHSSLKHSLGTSSGKLKTVTLKVKKWQKISSAKEQKAIKNIINLGSPCDSTLLTNLTIAPKHISTIFSPEADGNCGYRVIAMEVYQDQEEWSKVKDKMLETFLKHQNNYYHGRMEHGNMPASNNPLIRSLQDKHSPLPQQHWFGTIDHPQLVANTFSRAVAVYWNSPIETGDCLFVPFATLPEKVEPIIIILDVNHFLLAKCKNTRNFCWPKINPFHKRIIQKHGLEDYSLMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N8R3</accession>
    <name>A0A162N8R3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_174619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD66904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284944.1">
        <property type="nucleotide sequence ID" value="XM_018437293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N8R3"/>
    <dbReference type="GeneID" id="28998199"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174619"/>
    <dbReference type="InParanoid" id="A0A162N8R3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="103" mass="12029" checksum="F92E819063CD061D" modified="2016-07-06" version="1">MLVSNKQDQKHKVWFTPRETGLDHWRLFSKDLFVYRKKTKVYATLGITPFELMYALVLSTNLAPYRYDTVYPAMIATTLSQYEYVLICDKSNIQVSELPQGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N9Y1</accession>
    <name>A0A162N9Y1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_146670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290518.1">
        <property type="nucleotide sequence ID" value="XM_018431703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N9Y1"/>
    <dbReference type="STRING" id="763407.A0A162N9Y1"/>
    <dbReference type="GeneID" id="28992609"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146670"/>
    <dbReference type="InParanoid" id="A0A162N9Y1"/>
    <dbReference type="OrthoDB" id="4332274at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF101">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="64"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD72478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="133" mass="15027" checksum="47CF76353A62296B" modified="2016-07-06" version="1">MIEDYIHDVQQNQTSYDPEYDQEIYNDAFLIFNVLSAHKITLANYERFFLPATKPTESYATTKTRRDFGIALAVASNGTAALLLHGRRTVHSQFHIPLFVDANSVCTITPTSTTGKLIKLSRIIIWDEASMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NCB0</accession>
    <name>A0A162NCB0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_160326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286024.1">
        <property type="nucleotide sequence ID" value="XM_018434162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NCB0"/>
    <dbReference type="STRING" id="763407.A0A162NCB0"/>
    <dbReference type="GeneID" id="28995068"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160326"/>
    <dbReference type="InParanoid" id="A0A162NCB0"/>
    <dbReference type="OrthoDB" id="2290256at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="65"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD67984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="207" mass="23568" checksum="0546211C608997A1" modified="2016-07-06" version="1" fragment="single">EKRTLDSLLDNPSHSTLVSNSVFNSPGTPNSCSSVKRAPSLLLNNIPFRGVNPFDYRKDDVRLGVAALQSELDGFKAALENTERLVRRVQADVDQTRSRMELLIKNIPESNFSALKRLEVDIEYILASRAKNPWLDTAYALLSYLLTVFALGVWTVICILKYGRRVFSFPWRLWRDYKAHMRERNKAVKQASLYSLSGTSSSRARQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NKZ9</accession>
    <name>A0A162NKZ9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Restriction of telomere capping protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_158615</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RTC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293218.1">
        <property type="nucleotide sequence ID" value="XM_018433822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NKZ9"/>
    <dbReference type="GeneID" id="28994728"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_158615"/>
    <dbReference type="InParanoid" id="A0A162NKZ9"/>
    <dbReference type="OrthoDB" id="128308at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039024">
        <property type="entry name" value="RTC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028094">
        <property type="entry name" value="RTC4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391:SF1">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14474">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01312">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Restriction of telomere capping protein 4 C-terminal" evidence="8">
        <location>
            <begin position="40"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD75178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="170" mass="19322" checksum="1EBFB17D01EA52E8" modified="2016-07-06" version="1">MHKTELKIKPEGVKRGYPLEIDFDALPERIKSLQAELERVISQDTPSIYRDAALQAYKDLGQVKARGTMAVMARFEYTLPGYYGSKGAAIMQKVLDTMFVKTNILTHETAAPQLPMEYLQQVLVPETAYRLIREDLAKQGLESQDAKQVMKESSEFGSVVHRDPDVMEHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PHT3</accession>
    <name>A0A162PHT3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_146291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291017.1">
        <property type="nucleotide sequence ID" value="XM_018431618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PHT3"/>
    <dbReference type="GeneID" id="28992524"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146291"/>
    <dbReference type="InParanoid" id="A0A162PHT3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="113" mass="12728" checksum="A1749579625925EB" modified="2016-07-06" version="1">MSHENAKTPSESPKESHFLICSVLFSLAEFDQDLSKLERCMDALIAKKATCKRPFLEQQELGRENIQQGCGKINKLANVIDISSAQRGGKSTISLYDLKEAHIPLHSTLWKHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PJD8</accession>
    <name>A0A162PJD8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_145827</name>
        <name evidence="3" type="ORF">PHYBLDRAFT_145909</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291477.1">
        <property type="nucleotide sequence ID" value="XM_018431540.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291559.1">
        <property type="nucleotide sequence ID" value="XM_018431559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PJD8"/>
    <dbReference type="GeneID" id="28992446"/>
    <dbReference type="GeneID" id="28992465"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145827"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145909"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD73519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="123" mass="13771" checksum="729B5B39F3C871FE" modified="2016-07-06" version="1">MNTVPHSIHSPWLKHKTQATKTQNPGTEQARDPANRNLQKNTGNLANQTRPANRTTVAQKRPRIKDSGSPTHLRGSQQEPYEQKVQANPTAVQAPPSNVYKRQIPEANRIENQSSTTIGYTHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PQJ9</accession>
    <name>A0A162PQJ9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_146976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD71996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290036.1">
        <property type="nucleotide sequence ID" value="XM_018431774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PQJ9"/>
    <dbReference type="STRING" id="763407.A0A162PQJ9"/>
    <dbReference type="GeneID" id="28992680"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146976"/>
    <dbReference type="InParanoid" id="A0A162PQJ9"/>
    <dbReference type="OrthoDB" id="2286466at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="1">
        <location>
            <begin position="60"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="169" mass="18928" checksum="89EF22C24A11836D" modified="2016-07-06" version="1">MPPSSSPAPIGECKSSNISKYLSAPEIFVGGPNGKSFSWLLHMDQLKKGIGMTDEEAILVAATHFCGMAAKWWAICEAKVTMWEVFSKEFKKQFVSQQMKDVRWTEIEETRQGSGQTVGKVALHLQELFGLVTLSNKAQKIRILLKALRPEIAYEIEKSGLPRSWDKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PSJ2</accession>
    <name>A0A162PSJ2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_143822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293617.1">
        <property type="nucleotide sequence ID" value="XM_018431077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PSJ2"/>
    <dbReference type="GeneID" id="28991983"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143822"/>
    <dbReference type="InParanoid" id="A0A162PSJ2"/>
    <dbReference type="OrthoDB" id="3261594at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="802" mass="91074" checksum="BC049FD54937B864" modified="2016-07-06" version="1">MNTNTSATRISGSNSDINATDYTDIAQDFVALAPSLQERNQSLFNSANQASLDEVHGQETAREVFTLTPYQQKRNQDVITSTDMAFLNAVHDQDISRAEENDFEAFMAPGSVHSISNSLDVRFDNNYTEPNEAEYNDSNNSNDYSYESVHGYLRICNPVNINTLPIESDFVTKNVNQESHVPFYEPNTYAEAATLELFYMFVENNISRNVFDKCIKIVNKYMAERGLPATNALLLYYKMDKILKDEYTVCTATYDMCMESCIRFRDVEASNLIDEEEQCSHCGSQWFRRERDTLVPVQTFKVVHLLQQLRFKLENSQERAKMAYDVFNGGAVRRLCEGGIVGQDDILVTMFVDQFNPFDNTKMLATIIHVVNLNIDPKERDIESFLEPIIEDFRMLATLGIQIQTVARQINVKVHLVMATACLSKGVSKHHTMCFFGDELPVCMRTVENLRQFEGNSYGVNGPNVFRDLSTLTSSAFFGLNEMYLLGHSIGKQLHKALGGKFQISPEIADNGDQQQPQQQQQQQQQSVYTFALNFRPNQIDRSITKFRADISAIFTGSWQSLEETTSQLVELPSVCCANGGDLVKACTIAQQWKVTEREVNIMEELKPTIFVMNQHMLAHLGYMMREMGLLRAYSCHPIERTIGEYRAAIGSWKEPGKNMENILFHKAGVKHCLGGWASRRRTTNRKTSNFEVASNDIAGPQLWTNQTRNSLAVVADECGMNYHNLVSSLACIWGQDSVFMVAETTDMVCITKMWKDDVVYRVQSSFEGRHVQANDLVVLKHLNEDQALCHCQLSVWHLAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PUV8</accession>
    <name>A0A162PUV8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Basic-leucine zipper transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_76024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294257.1">
        <property type="nucleotide sequence ID" value="XM_018443113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PUV8"/>
    <dbReference type="GeneID" id="29004019"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_76024"/>
    <dbReference type="InParanoid" id="A0A162PUV8"/>
    <dbReference type="OrthoDB" id="2257100at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12193">
        <property type="entry name" value="bZIP_GCN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="221"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD76217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="301" mass="32458" checksum="30FC62EB464C2AD9" modified="2016-07-06" version="1">MSAAPAFSHTAESKPTMDETVFQQLFESFATPQDMAMSDNTVFDEWLVHPSLPSPNTSEHSSPEIATPLDAFLRSPPFDNKDNICLENAGFGLDLDMSDILNSPLFDVASPDLSFQTSPIVDPVVVHHQQSQQSAPAPVSISTSTAQQVSHLFSDLGGLPAALAALAAANPPPGVPQTPVVVATSAVSPSPSPVFKSQTKRARDSIDEDLGQFSPCEAALKRQKNTDAARRSRLKKVMKMESLEIRVSDLEKINTSLLLRVAVLDSEKSNLQIKESSYESRIKVLEAQLAEAHKALAGRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PVR2</accession>
    <name>A0A162PVR2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_143417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294487.1">
        <property type="nucleotide sequence ID" value="XM_018430979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PVR2"/>
    <dbReference type="GeneID" id="28991885"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143417"/>
    <dbReference type="InParanoid" id="A0A162PVR2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="142" mass="15266" checksum="32DAD16D3EEB81BA" modified="2016-07-06" version="1">MKFSLVKLICSKGPQKDPKHPKHLSIPTVRTQIRLETEVAASLLNLDSVQARPQLKDTYFAAPNTRYMGKKPVAVTTSSAPPQASVGQVFCIGDSVSSSLSSSSAGCDSQDLDEGYSSTALSVLDPDITHVCDVAFFERSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PWM5</accession>
    <name>A0A162PWM5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_131647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294717.1">
        <property type="nucleotide sequence ID" value="XM_018429431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PWM5"/>
    <dbReference type="FunCoup" id="A0A162PWM5">
        <property type="interactions" value="186"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162PWM5"/>
    <dbReference type="GeneID" id="28990337"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_131647"/>
    <dbReference type="InParanoid" id="A0A162PWM5"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="85"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD76677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="293" mass="33320" checksum="1289584CB844F226" modified="2016-07-06" version="1">MVVVYILYLVYFAIAITLALSILLYVYQCDLLYAAGFPTGSRSVVAKPSQYGLPDKEEILVTKDGVKLRSYVLIQRGDDVAIQSPTLLCFHAHTGNMGHRLPIAQVFFKKLGYNVVMLSYRGYGLSEGNPNEKGLQIDAQTVLDYVLRHPILRHTKLVAYGQSLGGAVAINLVSKNEEKFQALMIENTFLSVPLLIPHIFPALRHLVYLCHQTWRSYKSIRYIRHIPILFLSSLKDEIVPPQHMAKLYKISQTGGIKVWRDFENGTHNDTCMQTGYFESIAEFIRDNVWDYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PYL7</accession>
    <name>A0A162PYL7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trehalose 6-phosphate phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_38457</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Removes the phosphate from trehalose 6-phosphate to produce free trehalose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23420"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="EC" id="3.1.3.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.12" evidence="3"/>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293516.1">
        <property type="nucleotide sequence ID" value="XM_018440107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PYL7"/>
    <dbReference type="STRING" id="763407.A0A162PYL7"/>
    <dbReference type="GeneID" id="29001013"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_38457"/>
    <dbReference type="InParanoid" id="A0A162PYL7"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF123">
        <property type="entry name" value="TREHALOSE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD75476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="298" mass="33316" checksum="AA4D5B2BB9D7F2C8" modified="2016-07-06" version="1">MSSATPTVEPLSHLQTHQTAKKPAELATKHNTRLLNTDSLSREYKSANKRLLMFDYDGTLTPIVKNPADAQPTQNLLRYLAALCRDPSNTVWIISGRDQEFLQTHLGHIERLGLSAEHGSFMKLAGTHEWIDMLQNADMSWKSTCLKIFENYTAQTPGTVIEQKKSSITWHYRNALDQDEAYRQSLLCYEELKKIGGVDILVGKMNLEVRSLLVNKGEVVKRIQTQEGPADFILCAGDDQTDEDMFRALCDDKRAFCVLVGPPNRETLAGWCVESSEQVVSLLGSMVPQVTNGSNSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q3L3</accession>
    <name>A0A162Q3L3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_58761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297756.1">
        <property type="nucleotide sequence ID" value="XM_018440381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q3L3"/>
    <dbReference type="STRING" id="763407.A0A162Q3L3"/>
    <dbReference type="GeneID" id="29001287"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_58761"/>
    <dbReference type="InParanoid" id="A0A162Q3L3"/>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052408">
        <property type="entry name" value="Exonuclease_MUT-7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47765">
        <property type="entry name" value="3'-5' EXONUCLEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47765:SF2">
        <property type="entry name" value="EXONUCLEASE MUT-7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="2">
        <location>
            <begin position="600"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="807"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD79716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="840" mass="95790" checksum="53CF1FC27BD2EDFF" modified="2016-07-06" version="1">MREVDADSSEEEWVISSTETPTLKKRSMQKPTKTPTVPPVHRPQRQTPQKSHRIIPIERRHTPLDLKTSCFDYIKDDELHEMCMTMDSKQLVTRLISVYKNSETYVNIRNIETPVFAFDFRLSDHLHECSDPCSFIQHCFFFCKRLITVVTYQDVLFQLAAHFDENAGDKDMTSKFRRQLAHATCSGLERFLDTPPTKRKEIREEKDEKDEKDEKDEKDENDIDLISFVDDADKIKKEEPNLISFDDDESDTEDEKDRANADADDEEEEDEGPVKTITLAQLLDVPPEIASRYTLTREHQIRCIRMIDTIRAPIMVYYAIDIFRLVQFLSKGGEFEEYGSKLCRLLMIHAHYNEAVACIRKLDLFDAFPIETLADHFFTIGQGLALPAYVKGNEVLQRKLLHIIDVQLRYNFAGSLGVVPKELLETVEEDTKLLPPMARLKERRFQKDLMTCGTKIVHELQLPDHEYHFIWLSQRYACLRWIITQRALQQTEEGDYSISASSNYNGLLLLVVQDNPALAKLVIKELVDIGDALAPAYFASLFGQEQFFCAYSGLPLVDRVVGRVKGEQISRHRSSLAPKKPRIGSPHPTEYYKLPPNSECVVVDNEEKLKRMGKLIEGTKLCGLDTEWVPQFAKTGPSRTALMQIALDNNIVFLLDLKVMFQPSNAHLLDLTEKILGDMFSNSKIIKLGTDGDINRSIHLAYDFGGDMILLRESIPAANSWVVHSMLDFKNIRLSYDSQTGGNIPGGLAGVVSMFLGVGMNKKQQLSNWELRPLTEEQLIYAAGDSFCLIDIYRILEQRKHPFLSTLNKGSGSEARAPSPSTLNIEVPVTPQSEQPFITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q4T4</accession>
    <name>A0A162Q4T4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine(9)-N1)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA methyltransferase 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1G9)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_100719</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="1"/>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298106.1">
        <property type="nucleotide sequence ID" value="XM_018427604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q4T4"/>
    <dbReference type="FunCoup" id="A0A162Q4T4">
        <property type="interactions" value="716"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162Q4T4"/>
    <dbReference type="GeneID" id="28988510"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_100719"/>
    <dbReference type="InParanoid" id="A0A162Q4T4"/>
    <dbReference type="OrthoDB" id="278300at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18089">
        <property type="entry name" value="SPOUT_Trm10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.30:FF:000001">
        <property type="entry name" value="tRNA methyltransferase 10 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="9">
        <location>
            <begin position="50"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD80066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="238" mass="27809" checksum="071ADA4B209055C6" modified="2016-07-06" version="1" fragment="single">LGKNAIKRILKEELWEASRPKRIQHQREKDKLKRAERRKLIEDGVLEPPPKRQRRPEITLANTNIVLDCSFSDKMIPKELQSLQSQIVRCHSANRTAPLSMPLTITSFDDAFEKVMDKKGGSWTNWKNVKFERKSYTELYDKKDLVYLSADSENVIHELEEGKTYIIGGIVDKNRYKGLCQEKATKEGIATARLPIGEYLQMASRKVLTVNHVFEIMIKWLEHKDWEKAFMEVIPQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q6C6</accession>
    <name>A0A162Q6C6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(2)-C6 fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_161132</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298526.1">
        <property type="nucleotide sequence ID" value="XM_018434349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q6C6"/>
    <dbReference type="STRING" id="763407.A0A162Q6C6"/>
    <dbReference type="GeneID" id="28995255"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161132"/>
    <dbReference type="InParanoid" id="A0A162Q6C6"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF27">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="637"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="809"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="651"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="809"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD80486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="828" mass="92158" checksum="F171A8F84BF9DDE8" modified="2016-07-06" version="1">MKNDEPYETTEISARKRSRATQACIICRKKKIKCDGTKPDCLHCQQAGTKCEYTECKKRGPRKGYVQLLEERLIQLENRLSNIGDIPTATTPPEHTPSPALAPAQAPESIQTTAPTLISAPTPAPQASTRTQSPILKRKSSETPNIRLIEQHDTVNSLSSSPNSAASSPQKTSKSDISPLSSQAYGSVTNDFPPIDIIMHLVDLFFKYINSVFPLIHRATLKQSINDGTVSRPLLWSVMAIGARFSDHPMIKTDPPYWAGEKFSVKATSMINATSLEPTISNLQFWGVMSCLEYGRASGPKAWIYGCIAVRICQELGLNREESLCVPILDKNGGVDTVAMALRRRIFWSCLCIDKFSSAGTNRPQYFDKVDTDANTPTVPESLLLRDPFQCVTVDGREITNDPLIDVSRYYLKLLGIFGEVNKFMARAKNDTAAISWPPIAEFTMLDKQLRNWKDTFPKRFQFTPANLQHHKENASLNYINMWLCSHAVWCTSVLVLHRGSLAYSELAAGDVSEELYQEIQSSINTCKSCVDSAMPVFQALKDLCGINLLPYMGYSAYIFATVLMTSTFSKDPESCKKSSRGLTILYDLIECLKDYWPMCERLATTTRDLLAAHNRLYDTQYRQNYLFDQSIPDMTTYSKSSETRHTPQRPSSTTPAPETPPTTVTTPNSTNNPTRNSINSLVQSPSAGYPYNNFGSSIMTHNPQNYSLPITQPINPHVNNSTLQQPFSLLSDHSQNEGGIGVGGDIDFNSSEFLYDSALFGQIMLDASSRGANTNATSSFQFDMPPMINYPNSNNPNQNLPLYQNSQMIPGTNTQQTYSPSKALWET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162SZP2</accession>
    <name>A0A162SZP2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_176438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441021">
        <property type="protein sequence ID" value="OAD65082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283122.1">
        <property type="nucleotide sequence ID" value="XM_018437774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162SZP2"/>
    <dbReference type="STRING" id="763407.A0A162SZP2"/>
    <dbReference type="GeneID" id="28998680"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176438"/>
    <dbReference type="InParanoid" id="A0A162SZP2"/>
    <dbReference type="OrthoDB" id="2285201at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="638" mass="72839" checksum="2F6DB0A1628BFDAF" modified="2016-07-06" version="1">MSQTSQFMTLFNVIFQAFYLVQAGGTAMLKFFRHLLVAFDKDTNLPLTIDALKTMTGFNFMTKSIVKYTVCNKCFAIYLPGNRQPNCTFEKYTTTPPTYCGNPLFSDTEADRAVPLMVFPYNSLKNALAQHFAKPGFEHQIENATEAEMWFCAESDAERAVLEKQHGTRFSELHRLHYFDPVRCTIVDPMHNLFLGTAKRMISVWKDLRYLPTAVLVRMQRLADGILVPPGYAVLSTKIESGFPYMKADKWQSWCLIYLLVVLKDALPEDDYKNWTLFVKACRKLTSPSVTYSEIDSAHQLLGEFGKECETLYGESSIMPNMHLHMHLHESMLNFGPVYTFWLYSFERYNGKLKNIKTNHRNGLEVTFIRVFLEKAFIGSFLRAYSTNLSSPLIEFLEGVAQVKSNSDSSSPLNLDAGHPPALPFSLAMFQQAATNPWYNVTGSEALPPTTLPIKLQPLTMMKDDHYQWLFEFYVKAYQSTSVSFCAVGRIPIGEDVFVNNRIQKVKKISLLGQEYCSGKKKKRGSFVRVLFLERTNDDVSEFPGQIEYLFTHTIKIGGVKRVSMFAFIKWFPAYHSSSHQPLADQGLQLWDKGFMEEDALCIVPVHRLHSCFALTTHKMQSGTQKHLVVSLPRKVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TB30</accession>
    <name>A0A162TB30_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_73170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441009">
        <property type="protein sequence ID" value="OAD65653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283693.1">
        <property type="nucleotide sequence ID" value="XM_018442797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TB30"/>
    <dbReference type="GeneID" id="29003703"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73170"/>
    <dbReference type="InParanoid" id="A0A162TB30"/>
    <dbReference type="OrthoDB" id="3247418at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="115" mass="12710" checksum="CA931C224FCDABAE" modified="2016-07-06" version="1">MSNNNNNSECKCSKCSSNSMGFVLVSTQTLRRHAQQDIVRQYQSGSSSSVIEVMSNDNDMEIDFEDNVDAEDQVEAEDLPLFGIDSLFDSESEDEGVIEATILDISDDESDDVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TH02</accession>
    <name>A0A162TH02_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_67213</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441025">
        <property type="protein sequence ID" value="OAD67073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285113.1">
        <property type="nucleotide sequence ID" value="XM_018441754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TH02"/>
    <dbReference type="STRING" id="763407.A0A162TH02"/>
    <dbReference type="GeneID" id="29002660"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_67213"/>
    <dbReference type="InParanoid" id="A0A162TH02"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD67073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="328" mass="37382" checksum="E664AAEC0AF49D56" modified="2016-07-06" version="1">MDPLFMPYPTLCTYCIELIKSYGKEISKDRKADIYNNSQYLAQEFNTSLSLPSNTVNGCPKGLCLCKNDDDINNLVNNTLDYYPNVLNYYNHRYIFEHVKSVLVTRYGNNICNLFDPPAQVCSVTSNLPKVLLSPASPTVSSSSPNSRPAFSKNVEFKDYELYQNVPECDPHLTASRTPRYQPEQTISPESSVFSTPYESPGPQFYLGPQKETESNPISPMFSALKTPFAPSSLPKVRKRETRSIPGSSSFSIQTPGTTTRIRKSKPKGLITEKKFKCIDCSYVTDRQHNLTRHECTHGGLRLRLKCPICDRKYWRQDNLTRHFKSFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TPT8</accession>
    <name>A0A162TPT8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_172692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286873.1">
        <property type="nucleotide sequence ID" value="XM_018436852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TPT8"/>
    <dbReference type="STRING" id="763407.A0A162TPT8"/>
    <dbReference type="GeneID" id="28997758"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172692"/>
    <dbReference type="InParanoid" id="A0A162TPT8"/>
    <dbReference type="OrthoDB" id="5592268at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="161" mass="18591" checksum="94531FE47E831080" modified="2016-07-06" version="1">MDFPLYYSIFYYLSWNGVFPSGTTDIVKRKVQRQVDKYVAFNKKLFQKDTTDLLGQELLHEGIAMEVIVRVHEEGPLTVTYVNEHGTYYLAEPNYCKLSGAVNGDMLVAFHHYKSMISDIQKERAMRQFNAWLKRSNPEATVDLSVAHPSKGTMTQLWCND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U361</accession>
    <name>A0A162U361_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_71588</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD73082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291122.1">
        <property type="nucleotide sequence ID" value="XM_018442510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U361"/>
    <dbReference type="GeneID" id="29003416"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71588"/>
    <dbReference type="InParanoid" id="A0A162U361"/>
    <dbReference type="OrthoDB" id="2289680at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="3">
        <location>
            <begin position="161"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD73082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="692" mass="76711" checksum="1585DC01D6EFA75B" modified="2016-07-06" version="1">MSSEQTTSNSPVLTAQSDLSMMEAPVNNQVINHADRTLQAIDRLREMLATCSSALADAIEHNMPEENKNSIRQTIAATEGDLVMLISAHGHLVRSSPVQAEQTAPQSRLVPRELPVFQWQGNEWDHTQKVYASIEECLDKFEDVLHSYSMDLNVDWHRLLPIVLSREQRSWFDNYLRSSPELPWSFARDAFIKAYGINDLERRVQLTHELMLMRMRTTESVSNYTDRYQRVRREADVADNMQAAIAYTSTLLPELARQVSLLQVNMPREKRDTIDKAASLARSIYSTVFLTARSNEPVARAHTLGSEQVSRTSSSSSAGRSSGSSRENAQSRERSTHKRCSLHGKGNHDTEDCRILKNALATKGGNRVEKAPHANKYVGSAPCRWCGEVWSHKHRCSSVSGSSSSSGSASGSPRGSAPHFAVRSIHTVTNDSTPSDASSSEDDQSMVMDFEQCSTCKYTSTHTDHNKRSTHSYLVPISLEEEKLWALVDTGATISSVSTKICSKLGWPTIPRNGKIVLATNNAIAHRLGVTKPIKVFYNNKHIIHSFEVLDLAENIDVSIGTDLMPSLGIHLLGLAESWYGSNTPQTPTPIAEIEKPNNAPAGTPTEHSQFMKALLPFIKANEAIPITSFCTVKESIVRLPTPPGQVVYRRQYPIALQLVPLMAKHINQWLTDGTIQRAPMSLVIPQASVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U7Z8</accession>
    <name>A0A162U7Z8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_63857</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292232.1">
        <property type="nucleotide sequence ID" value="XM_018441193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U7Z8"/>
    <dbReference type="STRING" id="763407.A0A162U7Z8"/>
    <dbReference type="GeneID" id="29002099"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63857"/>
    <dbReference type="InParanoid" id="A0A162U7Z8"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000217">
        <property type="entry name" value="Methyltransferase protein 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF80">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="4">
        <location>
            <begin position="56"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD74192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="217" mass="25335" checksum="3697A4632AEEABFC" modified="2016-07-06" version="1">MVASTSLDVVPDDPTAYKTQAYWEERYQKENADTTFDWFKTYEELKPLFSEIIPSKEASILMLGCGNSTLGEDMYKDGYKNITNIDYSKTVIENMKSRCVHMPEMKWLEMDIRDLKFDSSSFDVVIDKGTMDALMCDRGDVWDPSEELIAEVKAEVDEVERVVKVGGVFIYITFGQPHFRKRHLTRDCWDIKTRTMGDAFHYFFYTMRKERPSVNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UB15</accession>
    <name>A0A162UB15_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_144254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292942.1">
        <property type="nucleotide sequence ID" value="XM_018431180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UB15"/>
    <dbReference type="STRING" id="763407.A0A162UB15"/>
    <dbReference type="GeneID" id="28992086"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144254"/>
    <dbReference type="InParanoid" id="A0A162UB15"/>
    <dbReference type="OrthoDB" id="2379842at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="62828" checksum="88E6BDD015EC5300" modified="2016-07-06" version="1">MHFGCTTTQRVESVHQALKREISAISSLGLAFEAVNSYVDRLERDFNSIKIRESTTVDALVGCNKQLSRLFMKVSKRALLVIDQELRLINRDDEFCHCKNRFEFGLPCRHSLPAGRELTLDDVPERWIINPVLKETSFEESCTVHIIAERPEEWMQEIVKLEALFRSCEGSQQVANLLQKIKKVTSEFEGKTGHPSINFQAPEKIKYPGRRKGGARPKYLPKDFGRANWRKISVSSGHVGLKAMVRLRARTRDGKPAATQKTKNNKKQNKSKKEPLDLIDATKNKIKQIKKEPLDPVDATKNKTKKIKQEPLDPVDATKEIGFKRPATAQEDYQYDYRTSVGKRVKFQPGFPVSHEIVDDVKGGFNPTADGWCGFRVLAHLIYKDQEKFPLVKRDMLATLPKYSSIYASTFGTNVKQLEDIIKHGSDLCITNSNSNFIPACLDANNPNTPSVSFLPFTLPKNISKHQQPLIFNHVNNNHWTTIHLSRNVSRKRPTIPELFFLGCVRNQIPDNFDTYWNKFKEFNKYDHRNAMFSFLSDQEERIHPTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UV24</accession>
    <name>A0A162UV24_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_154340</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296283.1">
        <property type="nucleotide sequence ID" value="XM_018433313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UV24"/>
    <dbReference type="STRING" id="763407.A0A162UV24"/>
    <dbReference type="GeneID" id="28994219"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_154340"/>
    <dbReference type="InParanoid" id="A0A162UV24"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF88">
        <property type="entry name" value="DELTA(5) FATTY ACID DESATURASE FAT-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="12">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD78243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="457" mass="51788" checksum="91D221E4506A140A" modified="2016-07-06" version="1">MPVFTREEFNAINQQVKDGVEGAKKYIVVDNKLYDITDFVADHPGGEKVLLTHVGKDATDVFHAMHPPSAYEMLANHYVGDLEPKAPAPVSVETQAGIDFAVEMRELREKLDKEGYFNASTLFYIYKVLSTLMLCGTSMTILYFYGRTSTPAVIVAAVILGIFWQQCGWLAHDFGHHQSSKDREMNDVLLVFLGNFCQGFSLSWWKNKHNTHHASTNVSGHDPDIDTAPVLLWDELASANYYGSLEDTPGPVTRFLAENVLPYQTRYYFFILAFARISWAMQSLSYSFNAGAINKSAKLNFYERASLVSHWILFTAATLTWIDSFRNMALFFVISQSVTGYALAFVFALNHNGMPVISQEKAEEMEFYEIQTITGRDVTMGAFGDWFFGGLNYQIEHHLFPDMPRHNLPKVKPMVKLLCKKYNITYHDTSVIKGTFEVLEALDVVQKLSLKLSKKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V020</accession>
    <name>A0A162V020_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acyl-CoA dehydrogenase NM domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_34926</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297143.1">
        <property type="nucleotide sequence ID" value="XM_018440041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V020"/>
    <dbReference type="STRING" id="763407.A0A162V020"/>
    <dbReference type="GeneID" id="29000947"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_34926"/>
    <dbReference type="InParanoid" id="A0A162V020"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF13">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="10">
        <location>
            <begin position="17"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="9">
        <location>
            <begin position="143"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="8">
        <location>
            <begin position="257"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD79103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="48544" checksum="5DA23B434ACF7FEC" modified="2016-07-06" version="1">MSSNALVDFSQLSPKFRDLYAKAKVFVEEECIPAEKTYNLQMGQGDQRWKVVPQVMEDLKVKARALGLWNLFLGQDYAEGAGLTNLEYSLIAELTGRSPKIAPEAMNCSAPDTGNMEVFAKYGTPAQKARWLQPLLDGKIRSAFAMTEPLVASSDATNIETNIRRENNEWVVNGRKWWISGAGDPRCAVYLLMGKTDSANKNPHRQQSIIVIPADTKGITVVRPMQVFGYDDAPEGHCEIVFKDVRVPLENIILGEGRGFEVIQGRLGPGRIHHCMRCIGMSERALDLMLTRVTDPSRKTFGKMLAQHDTVIAEIATSRMEIEQARFMVLNAAKKIDEVKAKGAMKEIGMAKVIAPNMLLRVLDRAMQAYGAAGISQDTPLAHFYASARTLRYADGPDEVHRNQLGKIEVRRAAALTEQQRIQKDKGDRLAANVSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V9J7</accession>
    <name>A0A162V9J7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_157047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299062.1">
        <property type="nucleotide sequence ID" value="XM_018433554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V9J7"/>
    <dbReference type="GeneID" id="28994460"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157047"/>
    <dbReference type="InParanoid" id="A0A162V9J7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="52" mass="6188" checksum="EE6AB5F5955639E9" modified="2016-07-06" version="1">MFESLKIIGQMSPSCVDPCFSWTRSQAHFRLKFPYPKKKEIEKKTMKLKKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162VAS8</accession>
    <name>A0A162VAS8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_161916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299342.1">
        <property type="nucleotide sequence ID" value="XM_018434530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162VAS8"/>
    <dbReference type="STRING" id="763407.A0A162VAS8"/>
    <dbReference type="GeneID" id="28995436"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161916"/>
    <dbReference type="InParanoid" id="A0A162VAS8"/>
    <dbReference type="OrthoDB" id="3263820at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD81302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="720" mass="83007" checksum="CEE443226435C44E" modified="2016-07-06" version="1">MAPIRKPTVRKECRCSICKSKTLGFDRVSVKTFKRHQEKDNHDITHVQTPHEDTCDTISSAVSEPVNQEEDGFEFEQEDVEMNSELRNLNDTNDILDIRTRNQPFSETDCVFGPEDNVQYTSDTYEEEYEDESDVEMDNDEDSSLESISELNLIHRFIVISVALFVSLYVVDEGAVILIAIINKILQFLFDPFRLPVSVAGLKRLAGFEALTSGVKKYVACSECHAIYDNEAAPLCCTSPNFVAHGVRWSELHRLQYFDIVRCTIIDPMHNLFLGTAKRMLERWVADGLIDDKKLVAMQKAVEKVVLPPDYTSLGTKIAKGFPYMKADEWKSWCLVYSPVVLRDVLPLPEFKNWIEFVNACRYFTKPSVSEEDIEKGHKCLEEFCKGCETLYDLDLLSPNMHLHLHLRQTMIDFGPVYGYWLFSFERYNSVLKNIKTNRRNGFESTFMRQFIEESWKGDFVRRLLKPMHALACFEIFDKFTTNNNNTNTNTNTNTNTNTYLSHSFSISEYLEASQNLSMIIRGNEPLPPSALPLKTRPLSFMPKHEYDCLVGYYQAAYKNPQISGCKDVIDDSPFVNDWIEMVKSVDLLGQSYKGCIGTNGRGSYIQAYFTERTGSEHAYVGEIQYLFVHNFRPTVSSLTYRNPHSSQHVFAFVKWFKSTSDKTRELEGVELLQDEFYKQDFQSILPVHRILLTVAIVDYKTTKNVNKKLAIPLPKKIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162VBT7</accession>
    <name>A0A162VBT7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_73443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299593.1">
        <property type="nucleotide sequence ID" value="XM_018442857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162VBT7"/>
    <dbReference type="GeneID" id="29003763"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73443"/>
    <dbReference type="InParanoid" id="A0A162VBT7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD81553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="100" mass="11751" checksum="7F67B1E6160E071C" modified="2016-07-06" version="1">MFHFTLSVIVIKYLVTSYVLSDLKVRTQLVILSLSIVWLFFSMGNPLRASTAWFYKIAIFDRDIKVLAESTLKIYLKVREKINCWAGSFFYVKVTIFDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162W8I9</accession>
    <name>A0A162W8I9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_176267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441029">
        <property type="protein sequence ID" value="OAD65355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283395.1">
        <property type="nucleotide sequence ID" value="XM_018437708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162W8I9"/>
    <dbReference type="STRING" id="763407.A0A162W8I9"/>
    <dbReference type="GeneID" id="28998614"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176267"/>
    <dbReference type="InParanoid" id="A0A162W8I9"/>
    <dbReference type="OrthoDB" id="5582742at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="309" mass="34555" checksum="BEB5D54F23C8512D" modified="2016-07-06" version="1">MAIRISPDECSSAKHAMHQEPLSLGTIIDMVISTLDKNYTWRHASNSQSFIFIFFSHYIVCILKLIYHSQHIAGLCTCNQISFGTSGNRQNPTVKCGIFTIVCLNFPMCIYCYFSSAYLDKTISKDPHVIANQTADQLENVGRAREAAELCMSVMSSKDKEKWDAVIKKVLFEIGNHVKLTHEGRFGLEPQFKGPFIVMNKNNKYGTYQLKTMEGKPLASWVHVDWLYKTNGDAPNDTWYNPTAYCSAWLAAMTLLDTKIPNDAVDPVASPDDIGAHGQSQSQEGIMSELTLVTKIGSYKQPAMVDFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162W9N7</accession>
    <name>A0A162W9N7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_175846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OAD65665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018437592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162W9N7"/>
    <dbReference type="GeneID" id="28998498"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175846"/>
    <dbReference type="InParanoid" id="A0A162W9N7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="112" mass="12158" checksum="AFBF26E054D66846" modified="2016-07-06" version="1">MSVNKNIVPKSNISTTSVFAIQASAPLHASWSKPDGDGRKNLEKYLGGTINGRIFKATKSGVINQCSQYFLEQGVIRTNSQIKTCVIFDLGCSSNAITQPKLVKPIGNCKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WCH5</accession>
    <name>A0A162WCH5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_80008</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441004">
        <property type="protein sequence ID" value="OAD66245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284285.1">
        <property type="nucleotide sequence ID" value="XM_018443535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WCH5"/>
    <dbReference type="FunCoup" id="A0A162WCH5">
        <property type="interactions" value="204"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162WCH5"/>
    <dbReference type="GeneID" id="29004440"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_80008"/>
    <dbReference type="InParanoid" id="A0A162WCH5"/>
    <dbReference type="OrthoDB" id="496at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="309"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="351"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="430"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="518"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="541"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="619"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="165"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD66245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="650" mass="71623" checksum="2A907D197A835B12" modified="2016-07-06" version="1">MPKDDATTPARPQRPNQSMTSTSRDISFSYDAFTSNPVVSVARERAVGMAQSAREWLSPTMPDWRAPLSQLESLTTVMFNPLAAHPVYRSESMAKAMQLMHQQQLQQQRSSGSSSSSSASSSSSSISTKKQIAWPSSAVLLQAEIPESSAPLSLFQGFSAAYPSFTNGPAKKQRHKRKKQSGTPKSSAQKAATKASRSMAQLIAEREKRARESDRLEMQKASTTNEVLQLNLQIEELINKRKLLEAKWAKLESKDRHLRASIEEINDAMAAIEDEGRDDGSVRSRRGRSIKEEEESEEEMESGTCFKTFEGHDERILSLDFNHPQGIMVSSSMDGTVRVWDLHRSRCLGTLEGHTSLVRCLQLDNTRLITGSDDGTIKHWDLSAVAAPSPSSVSSFSVYSSEPSSPTLSAYTTTQDDIIPLPSECYLGAFEGHSAEVTALYADEDTAVSGSNDKTMKQWDLETRQCVLTLDVMWASKSAEGTNSWSSFDRWSLDSLQQSLFEPASDFVGALQFWNFALASGTLDGKIRMWDLRTGQTHRTLPGHNGPVTSLQFDEVHLVSGSTDKTIRIWDLRTGSVFDTLSYSGPVTSLQFDSGKIVSAGSTPSIDVYNRTSFQHNSLTGHTGAVNSVRFRKNVLASGGKDKVVKLWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XFX0</accession>
    <name>A0A162XFX0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_67468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292655.1">
        <property type="nucleotide sequence ID" value="XM_018441799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XFX0"/>
    <dbReference type="GeneID" id="29002705"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_67468"/>
    <dbReference type="InParanoid" id="A0A162XFX0"/>
    <dbReference type="OrthoDB" id="2288597at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="117" mass="13415" checksum="90D5C3E34D6A1CC7" modified="2016-07-06" version="1">MSDINELSKETVQELLQLYKQLKRDSQTTDQFKPIELPKEIHDDIENALSISIKQNLKRFAKATLQYHGGRWTQPEAINAVFKSKLKKHQVEASEMVAAIHKGAEWIRTTARAATEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y841</accession>
    <name>A0A162Y841_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_103466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296945.1">
        <property type="nucleotide sequence ID" value="XM_018427768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y841"/>
    <dbReference type="STRING" id="763407.A0A162Y841"/>
    <dbReference type="GeneID" id="28988674"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_103466"/>
    <dbReference type="InParanoid" id="A0A162Y841"/>
    <dbReference type="OrthoDB" id="2258541at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046368">
        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895:SF1">
        <property type="entry name" value="LIPID-BINDING SERUM GLYCOPROTEIN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="130" mass="13519" checksum="D50AFD3288365BB5" modified="2016-07-06" version="1" fragment="single">PIGVQLGTIKMSIAYSGVTIGQVSAENIVLAKGDNNIMLKGVLTPQNDTASLDKVSELFSAYMAGRISQTSAVGISCAPNGVDPVGWLSEGFKTVSLNVALGSSEAMKVIHGINMGYLDLVFNKDAPYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YIN6</accession>
    <name>A0A162YIN6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_138504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298995.1">
        <property type="nucleotide sequence ID" value="XM_018430012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YIN6"/>
    <dbReference type="GeneID" id="28990918"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138504"/>
    <dbReference type="InParanoid" id="A0A162YIN6"/>
    <dbReference type="OrthoDB" id="10519047at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264">
        <property type="entry name" value="EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="657"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD80955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="807" mass="89282" checksum="2821B7890BA54B2A" modified="2016-07-06" version="1">MERGNCICTQIATLLEPVENDESEEYDLVEREDSAIGNALEMAQNTDFFRNQPKTNVVYQRPLPGNPVEFRVMFLGNMTAKDKHILRSKLCQMLVESYRTSQKIKTKTKTRTITKNSSPLSREFLYQALTHLDDHGRQSYCPDSGIHLIEVDMTWFKPIDSLRNHYYHDMDIDVFSPPDVHQRAKRYLKSHSALTAKEIYQTHRGIDFAVYLYGSLSDLSREQTEGDLKILGLVQDHRIPILSLIRSNDDDDDNDDNDNDDNDNDIITSSGNSNSNSNSNSNSNSNSNSNSDIVGGSSSDNAPIGLKKAHKDTFASRTIVVGMRHKLRQYLNAYRIECLSLTGIQPEAPTFASQAPLPSPDLMCLDEFSSLQKESLRDLHHTLVQKLNRTSLNGRYGDGDGDDDDDGGGGGGGGSSSSSSSNSSSNSSNGNNGNGVSYGYSYGYGYGYGGSGCDGCDVAAATGAFSDMSDLFDTTATIINDTAAVAATVSGGQIGCLSRCVTYLLAGIVLGITLAIILYTSFFCRLTEIPSAELLPVSNAPDSNSLRYLFSVSVGGESSRERSSDKATATQPSSLWVRLTGIDNQTSYGDWPMKLNTSTGLYTASVPSPCLFHSPTDFLASVWIAGVMSPDQSVQRLTLEACQPQHIQPKQERNDASSQQNSKNNKQQEIEEQEIKEDDEDTKGDEEANDLMCSLSSPEATKRTKRYGGGWQMIAWQDSGFETLWKEWIKKIRSLLWIVKDRAWECIIKAEITSASLSERDYQQEHIVYHKASGLILPDIVIRFWVVLETTDSGTLEKRCRTQFKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZBB4</accession>
    <name>A0A162ZBB4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_184120</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SRP72 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441009">
        <property type="protein sequence ID" value="OAD65591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283631.1">
        <property type="nucleotide sequence ID" value="XM_018438887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZBB4"/>
    <dbReference type="FunCoup" id="A0A162ZBB4">
        <property type="interactions" value="504"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162ZBB4"/>
    <dbReference type="GeneID" id="28999793"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_184120"/>
    <dbReference type="InParanoid" id="A0A162ZBB4"/>
    <dbReference type="OrthoDB" id="5421607at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013699">
        <property type="entry name" value="Signal_recog_part_SRP72_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031545">
        <property type="entry name" value="SRP72_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08492">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17004">
        <property type="entry name" value="SRP_TPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038922">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9" id="KW-0733">Signal recognition particle</keyword>
    <keyword evidence="10" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="464"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Signal recognition particle SRP72 subunit RNA-binding" evidence="13">
        <location>
            <begin position="552"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="547"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="578"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="594"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="613"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="642"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="660"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD65591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="674" mass="75005" checksum="BFEE1D24211D8AE7" modified="2016-07-06" version="1">MATTKEEQVSNLYSELKKTTDEYEDERSLSICDSIIQLDPDDQVALHCKVVTFIRLDKYTEALSLITRKFKKSDIDLNFEKLYCYYRTNQLQPALELLNELKKTKKDDVGLQYMEAQLLYAQDNYEASIKVYEKLLKSTNKNDRLYEEIQVNLLAAKAGLLFANPKAKDDVKEPLYDVSAPGAYEVAYNAASVHLARSELDLAREQLESARKQCNERMTEAGLSHEEIDEELAVIAAQLAYTYQVQGRTEEAKELYESVLNSKASDAGVTAIVSNNIVAMQETKDLFDAAKKLKVATGKEAENKLKRYQKRVIAMNESLLQLYMNKHAACRDSAQRLIAKYPDSDTLYLILAAATYHQSKGEKAVEELKKYAEKKPESLAIRFATIQLQLLQSQPAEALSTLESYLKVIDEKNKKGFYHQQPAVVALLVWLYEQTNQSEKAMETLDKASTLWKSDSSFLKSAPASIIKQTAAFKLKAGRYSEAAADYEQLVKADPTDSQTIAGLISAYAEIDPAKAEQYGDALPAIAMHHIDVDTLERVVPGVKRGYVKKDPKGTHVKKVKTKKKRQPLLPKNCDPSRTPDPERWLPKRERSTYRAKGKNKKAALRGPQGSAVEGGGIGGTGSANIGGRGAPVVVEKEVSEPKPQASTPSSTAAPSKAAANKKKNKKKGGKSKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZFF7</accession>
    <name>A0A162ZFF7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_128550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EMC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441003">
        <property type="protein sequence ID" value="OAD66431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284471.1">
        <property type="nucleotide sequence ID" value="XM_018429222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZFF7"/>
    <dbReference type="FunCoup" id="A0A162ZFF7">
        <property type="interactions" value="264"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162ZFF7"/>
    <dbReference type="GeneID" id="28990128"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_128550"/>
    <dbReference type="InParanoid" id="A0A162ZFF7"/>
    <dbReference type="OrthoDB" id="124397at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055217">
        <property type="entry name" value="TPR_EMC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22890">
        <property type="entry name" value="TPR_EMC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="EMC2 TPR-like" evidence="4">
        <location>
            <begin position="86"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD66431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="275" mass="31707" checksum="73E7D219A8B82BE9" modified="2016-07-06" version="1">MSRLDSAAVVEELQSYRLTNERKSERVAALGARLIREKQLSKLGEQVWPIYEQIAVAAFDVGDLELANHCIAQLRTRFNEKSLRFKRLTGMKLEAEGKLGQAQAVYDSILEQDETNMLASKRQIALFKERRKDQEAMEALTKYLDTYYDDHEAWLELCHLYLSKHAYEQAAFCCEELLLLQPGNHIFHLKYAEIMFTLHNYPLALKQYCKVLELCKDHVRALYGLDLCASKLLESKDTEYAQDLHALAKERLLDVYSAKGTNDTSKVVQTYLSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZL78</accession>
    <name>A0A162ZL78_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_151461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285601.1">
        <property type="nucleotide sequence ID" value="XM_018432687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZL78"/>
    <dbReference type="STRING" id="763407.A0A162ZL78"/>
    <dbReference type="GeneID" id="28993593"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151461"/>
    <dbReference type="InParanoid" id="A0A162ZL78"/>
    <dbReference type="OrthoDB" id="2439595at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="171"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD67561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="486" mass="54330" checksum="D0B61D3851D66712" modified="2016-07-06" version="1">MANNVYSTTALEANHNPPQPPHHDFVDQRTPIEMNPSRSMQRSKTVRNLGNAGSRVRGFFKKQNSKEVDSSKPTQNIRDEPQSFSPASTQRPTRPVLPSSSSYSPKSQFEQDSADLSRPPSYNIERAAQEKDSTMDTRISQPPVTNGIQNITPLTTDKGHGESAEPLNSEAAELMREIEQVNASITRAKQEIEAEAEKKQTLQAELDEARRVFQAREMEYTQVEHSFFAHTRAIRATDDDLSTIRDSFKLLKYSITRVIMTLNKKADRATATECLVAAWPNLNVLDPNSPTKELESAHINLLAEKKVHEHLVQSVFRCPIYPGLSVNESFAALNEWLISHDSKFNVRLRQQLASIVAKNSKEGVIFQAGHAEKKKIADMIYNDIADIYAPFVRENDAAVEEDKRYSTKITDIVDKAMRLVVAIRGQDVDISTLDIEEGKQAFDEETMVDVKGKTTGIIRFCICPVFVGGDGEHGFLEKGKVVVGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZUR9</accession>
    <name>A0A162ZUR9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_159861</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287191.1">
        <property type="nucleotide sequence ID" value="XM_018434072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZUR9"/>
    <dbReference type="STRING" id="763407.A0A162ZUR9"/>
    <dbReference type="GeneID" id="28994978"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159861"/>
    <dbReference type="InParanoid" id="A0A162ZUR9"/>
    <dbReference type="OrthoDB" id="79171at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21182">
        <property type="entry name" value="Tudor_SMN_SPF30-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="4">
        <location>
            <begin position="92"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD69151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="258" mass="28543" checksum="3901D3B1FFA0715F" modified="2016-07-06" version="1">MNAEEAESYQYQLDQVDLALSKDPDNEELKKLHHDLKELIALTTQFESAQQQQQQQQAQQQQTQQTSTKRSNASSTNPILSTPISTALKSNQFTVGQEVMAKYAGDGEFYRATITAIGGADQVFSVVFRGYQDNELVKAEDIKALDNKKRQGIFEEAPKQPLAAPPKKKKKEKTPGVKKVNETEVKKNAWLNFASGSDKKKKKVAAPINKKSIFKTPDNPEGRVGVVGSGRGMTTFQQRGKHVYADGQNNVGAGEEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163A0T0</accession>
    <name>A0A163A0T0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_171674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288331.1">
        <property type="nucleotide sequence ID" value="XM_018436643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163A0T0"/>
    <dbReference type="GeneID" id="28997549"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171674"/>
    <dbReference type="InParanoid" id="A0A163A0T0"/>
    <dbReference type="OrthoDB" id="2214613at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026960">
        <property type="entry name" value="RVT-Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13966">
        <property type="entry name" value="zf-RVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase zinc-binding" evidence="1">
        <location>
            <begin position="445"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="600" mass="67821" checksum="A4B503BB0F3F5B26" modified="2016-07-06" version="1">MLGDFNYSSYANASRAGLAPRLWLHFVANHFVDCVTLSDAQPMPTFHRDLSSSTIDYIYASKDIASCHSSSTVTFVQPLWTDHCLVRTYLSFPMLSHIGRGLWRANPRLVNIPSFRSSLSDCLSSFIPLLSPSISPQSQWDLIKVEVARFTRSYSRTTRPSLATLEIESTCNIHHSRSLSIRGRATVLNSLILSKLWHVLRVVTVPLSFFRRLRSIMTALQLRWLRPLVRSPLSPSGLVPPWFSYVLRLDSSSADPLVPLIFPSLRSSHQRDFDSPLATLLAAIDLLPHNFSDVVVNLPTCLSLPLSYLTTAQPDHPPFPSAWRDLRVSDAYEVDPSFGVLAQRPLHRILRRPIVLHRFFERLYTRSLVLHPVLYRATIPPAICAIQFPSLDMPSGTAVYVRPFLTALVPGIPWHRLSTQSFRLLCNFHSKSARPISPTLVPRQLRRFWSFPLPHGARNVWFRALHKNIPCRSRLNSRTPTAFPDPSCALCSHPLDNQTHFLFQCPVKLSVWSSIWTLYFAQTATPTVLLSGLQSFTFPPCTDSSLSAASIFGCTLLAIWRHHWLFIFDHVPFVSSAAFSTASSLLDRLKSELALDFPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ACZ9</accession>
    <name>A0A163ACZ9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_169753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290671.1">
        <property type="nucleotide sequence ID" value="XM_018436156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ACZ9"/>
    <dbReference type="GeneID" id="28997062"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169753"/>
    <dbReference type="InParanoid" id="A0A163ACZ9"/>
    <dbReference type="OrthoDB" id="2206543at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="681" mass="77106" checksum="D3A0C6CF0D7B4DC4" modified="2016-07-06" version="1">MGSFLGDHAITSRGTSFLQWIQATGLTCWNELLAFGIPTFLSGGSGTSRSSVIDLFLSTSPLLNPSMQIRSDLSLGSDHKMVNLTFTPYVSPPPPPTNHPRLLWNLSKLAQPDTLKIYIDTASGSLDNLTEQFSAFLSSSSPPPVDSLCSAFAQAIYDALDTAVGRRTPCTMQKYWFWSVDLQEAMDLRERSYQRWRHSSGLQKAICWMRHQDACHAVRLSVQRRRRETWKEFCNKLATQDFAKTTATMKRIKSHRQTSPVFVDPGGPQVAANKMADHLQQIFSGQFLPARRPPDQTVMISSPIAIDESCPFTHLSVESAILKLPTRKAPGVDHLRAEMLHPIVKQVSPVLCLLFQLCWQWAKGTIDPSLLISRNCVSAINSMRALQSLGVNHTGLSRLLSIRLYRQFIRPQFEYGLAISCFNIKQVAVLEKAQNTCLRMIFGGHSTSSTSVFRHLGNLPSMRERILTLGFKFVYRAFWLPDEALFTLLQPVLTNPAHQWFKLLANPIWLSLSNRQNADSKACKHAIRSFLNQGLFLQRSQQILLSACRPSLGVDPILWLPMTNYERSRFIRWRMGWLPGRPQPCSCGLHTTSRHHVIECTGAAIRLHLYSTVQPNPIDYVLNMLPLKKPKNNKNNAFWIFTWPILCRIMLDIEQICLSGVDLADHAVTDREQLFLNWLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AD56</accession>
    <name>A0A163AD56_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_145984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290711.1">
        <property type="nucleotide sequence ID" value="XM_018431573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AD56"/>
    <dbReference type="GeneID" id="28992479"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145984"/>
    <dbReference type="InParanoid" id="A0A163AD56"/>
    <dbReference type="OrthoDB" id="2382535at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="254" mass="28016" checksum="059D7825F6AA3C4F" modified="2016-07-06" version="1">MGTGKTILINNVVRPCHNVVCHCTLCSRNSLGYSLVSGRTAERHIVKEKLERVERSDAAERFANSVQEEEMMDVDTQYNQTDSTNSNAAIMADNVSVDDEISEVNDNDSESNDSSEEEDAETDIEELIAKDFFAASKIPANPVHQFIATFTVLFASHYVINKGAAVLIEFVNQLLKIYGEDFQLPSSLSGLQAMTGLSNFAKSIKKFVVCQDCYKVYKQDVPLPTNCDFTKHDARSTCSCTLMKVSPSGAMVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ADN0</accession>
    <name>A0A163ADN0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_125170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290801.1">
        <property type="nucleotide sequence ID" value="XM_018429034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ADN0"/>
    <dbReference type="STRING" id="763407.A0A163ADN0"/>
    <dbReference type="GeneID" id="28989940"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_125170"/>
    <dbReference type="InParanoid" id="A0A163ADN0"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="56"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD72761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="313" mass="34975" checksum="E986A38D5701D6FA" modified="2016-07-06" version="1">MLAYAFGPTDRKTLGSHSDSPSEYYPPDFYPNGTDLVLPMGSIRYWLMGDPNGKKVVLIHGISTGAACYISLSKILADKGHYVLLFDLWGRGYAEAPPHYYDESLYTTQVALVLQKVGWTSTDVVGVSLGGAIATSFASFYPEMVNKLVLIAPAGLMHRADIPMSGKIVAHPLLMRLFEQGWIQPFARKAFKLFIDNSSLRKELADDPLVDQISSVATHQFIHHPGFIRAFLGTLADYPLSGLDERYRILGNYSNIPVFVLWGDNDKTVPYKYHHVLQKYVPHAQISHYKGGGHDILLSHRDRLNSEICDFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AFQ0</accession>
    <name>A0A163AFQ0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_65779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291221.1">
        <property type="nucleotide sequence ID" value="XM_018441532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AFQ0"/>
    <dbReference type="GeneID" id="29002438"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65779"/>
    <dbReference type="InParanoid" id="A0A163AFQ0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="200" mass="22546" checksum="EDB31E6CF617BBCB" modified="2016-07-06" version="1">MLEEYCPIMDYCHPLFNLILDRFFVLRGAKKITAPARAYESPQTSQEKSDSHISILLKQGTRPDNSIRKFIRAISMDNYQSIATACSKNALVKEEQGRLGILSKLENSSKIKVPYIVYVSDSQSTFSVADIQVISRPVKDLLPKYLQNKTSSSLITREVLTENNSHLFVVVSVVVISSGLISRKQLVPRFPVLRLNNPQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AJZ3</accession>
    <name>A0A163AJZ3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_168401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292031.1">
        <property type="nucleotide sequence ID" value="XM_018435863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AJZ3"/>
    <dbReference type="GeneID" id="28996769"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168401"/>
    <dbReference type="InParanoid" id="A0A163AJZ3"/>
    <dbReference type="OrthoDB" id="2285535at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="168" mass="19395" checksum="0B8AACF6C6EEEA8C" modified="2016-07-06" version="1">MEDIPENSIWIQSSKWNTKIRSKKSGLVLAFAQMKESLPNIGYALKYHPIIDYRNALSAACKTITAPYLENIVEHFRQRAIYYLKFNLRQIHEWLKTTAETIWSEAHLFGLTVVPCLILTTKPEYSKFVSLSEKMIVTSTMVNISSSPDSFISILGFILTYVERIRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AKU0</accession>
    <name>A0A163AKU0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_112042</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292231.1">
        <property type="nucleotide sequence ID" value="XM_018428260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AKU0"/>
    <dbReference type="FunCoup" id="A0A163AKU0">
        <property type="interactions" value="477"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163AKU0"/>
    <dbReference type="GeneID" id="28989166"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_112042"/>
    <dbReference type="InParanoid" id="A0A163AKU0"/>
    <dbReference type="OrthoDB" id="18894at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="4"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD74191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="363" mass="40708" checksum="35E91EEAEDA7030C" modified="2016-07-06" version="1" fragment="single">FATILSVYNKWMFSAEHYNFQFPLFVTTIHMVVQSIFAGCSLLIVPKLRPKKIPTGKEYIYKIFPCALATSFDIGLSNLSLKTITLSFYTMCKSSTLAFVLLFAFMFKLEKPNVKLITIILIITAGVVLMVSDETDFVWSGFLEVMTASVCGGLRWGLTEVLLRKESMGLTNPFVSIFFLAPVQAIVLLVLSGAVEGYITIFKSAFFVTFSDAMHTMGIILLGGSLAFFMIMSEFFLIKRTSVVTLSVCGIFKEVATIFVSTLVFGDRLTIVNTVGLCITLFGICLYNWMKIRNANQAANKAIEDQEMSNSQELDRSEDPKHMYNMAAESTPILMVDGALTTYRDSDDFERRRSSEQEGYELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ARJ0</accession>
    <name>A0A163ARJ0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_166540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293321.1">
        <property type="nucleotide sequence ID" value="XM_018435432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ARJ0"/>
    <dbReference type="GeneID" id="28996338"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166540"/>
    <dbReference type="InParanoid" id="A0A163ARJ0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="134" mass="14939" checksum="3D7765673834615B" modified="2016-07-06" version="1">MLICPATITLVQKLWSLMDFTPPQEVHLIDYALNCLPRSLKSPGTWCDWWPCLLALLRAVDQTTSSYKLPEEKAHGQILIALAAKFHATKPIRPHRILPPTQEPVPGDPFPHLLSEISTVPHQPPPSVPARNCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AWK0</accession>
    <name>A0A163AWK0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_186211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294301.1">
        <property type="nucleotide sequence ID" value="XM_018439203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AWK0"/>
    <dbReference type="STRING" id="763407.A0A163AWK0"/>
    <dbReference type="GeneID" id="29000109"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_186211"/>
    <dbReference type="InParanoid" id="A0A163AWK0"/>
    <dbReference type="OrthoDB" id="2275774at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="575" mass="64520" checksum="2B1061672800C6C5" modified="2016-07-06" version="1">MIIKTVCEKRQPKKNTKKRRDEVEVEVEEMKSQLLSQNNITSSIQSINTETKPKQNLKFVFSPSNNQPSPQAPSTNKIILDYLLYLSIQSRLKQAHVELLELSLPLPDNDLQSRKQRWKDTASKAEQDKNAVESIVAGILSSHQNKKPSFKIDANFEQRLHLCQLTNLVFGRFDATSTAGCHVIAHNSARRKRHETQMASMIEDKEDETCDIKRRQQLFARPVIPTFCRRHRRQDCPGCQSPFSTTKASSSTISSSSSSSLLSLSSPPISASVEAPPPPPKTTTTQESASVSASASVSASASASEPLFNTETTPSGSTIIPPPGLMEAIPSFLKTSADMLRHTLETGEEGDPTPLTFAGQKVMGGGMPPRWYDLFLELLTQAAIESYLCDAQVGLEPIFEIFSYGDVEDEEEEEDEDDEEEEEEEDVWGVRAADHHLLFPKTRTMYLFKTQVREREKEFLIVQAGTDLRQHFEKLAQRYPLETFEKSMGEFIQMTLSTMETPALDKCEEEEEIQTPENEAPAANRLPSLYKYPGDGALLMPEIPDVEEHDIEPRGIKRSNTTTATTDSHDPKRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B0S1</accession>
    <name>A0A163B0S1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysophospholipase</fullName>
            <ecNumber evidence="6">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_179930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="6"/>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295651.1">
        <property type="nucleotide sequence ID" value="XM_018438235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B0S1"/>
    <dbReference type="FunCoup" id="A0A163B0S1">
        <property type="interactions" value="288"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163B0S1"/>
    <dbReference type="GeneID" id="28999141"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179930"/>
    <dbReference type="InParanoid" id="A0A163B0S1"/>
    <dbReference type="OrthoDB" id="6121437at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF40">
        <property type="entry name" value="PATATIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLA2c" evidence="7">
        <location>
            <begin position="187"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD77611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="764" mass="86850" checksum="240FA0ECF52CB365" modified="2016-07-06" version="1">MPFFAAWSIQTVRQRAFLIGVGASTVTGVLLKCHYAKDNTPLIIREPSLPFRILCNFIPIVALEPADPSTPQSPPKGGPGAWLDSTRKIFQVDRMQEDVRRENDFISKMFSLKSTLPTMPKINIPEPHIPSVEEINQRMNELYPTFASQFDTLRESYEHFWDFLTMEDFRKLIDDIQREDQDGLIYPEVGEDAIVREGSGLSKEEKKFIKVRKERQRQSFAKFMRVDPHEVELEDMPIVGIASSGGGYRAMAGCAGYLKGMRDTGVLDCVMYMAGVSGSCWTMALYYSPLSGGSLEKLSGHLQTHMHTHLANVSSFLTVLSASKNNAKLLMQGVLERYYQQNNTLNVVDVFGMLIGATLLTKKKIDNTMASESSECQDHSIDTEGSSKKKEDILRGIVTEEDGTQRKPILLSKNAMKLSCQDDVFGDGSQPMPIYCAVRHDNAHTAEEEKDIYQWYEFTPFEMGCEEIDAWIPMWGFGRKFDQGKNLERLPEQVFGSAFAASLVQFYQEVRSFLPKRAIDASDEIVLRYQESMSNYHPISPASFPNPFYNLPEYGPIEEGCTFSRPKSLIESKELCLMDAGMDNNIPFYPLLRQGRDVDVILAVDLSADIQTAHHFDRAEGYAKRRGVKGWPVDAGWPKQHHSSKTNDYPLGTCTVFASHALETETEEATGETYQTKAQRVTVVYFPFILNKAFDPEFDPQTAEFCSTWNFVYTSDQVNKLEGLAEKNWTENIDQVREVLRKVWDRKRRQRLEKLPDIENPFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B1X0</accession>
    <name>A0A163B1X0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_141693</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PET100 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295871.1">
        <property type="nucleotide sequence ID" value="XM_018430646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B1X0"/>
    <dbReference type="STRING" id="763407.A0A163B1X0"/>
    <dbReference type="GeneID" id="28991552"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141693"/>
    <dbReference type="InParanoid" id="A0A163B1X0"/>
    <dbReference type="OrthoDB" id="18175at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018625">
        <property type="entry name" value="Pet100"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968:SF1">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09803">
        <property type="entry name" value="Pet100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD77831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="90" mass="10534" checksum="A71D9A7CFC9AD13E" modified="2016-07-06" version="1">MGGPRLEVIKFGVYVFFPVGVMLYFGGPGFYDQYVKGIKFWPDYNTTYKPPTTSEEIKASLEKMKAEREERWRQNMRAKQALKDQAESQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BDN2</accession>
    <name>A0A163BDN2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7082 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_104999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298931.1">
        <property type="nucleotide sequence ID" value="XM_018427874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BDN2"/>
    <dbReference type="STRING" id="763407.A0A163BDN2"/>
    <dbReference type="GeneID" id="28988780"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_104999"/>
    <dbReference type="InParanoid" id="A0A163BDN2"/>
    <dbReference type="OrthoDB" id="1751210at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055509">
        <property type="entry name" value="DUF7082"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463:SF1">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23305">
        <property type="entry name" value="DUF7082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7082" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="161" mass="18970" checksum="26DEE08BDE266F95" modified="2016-07-06" version="1" fragment="single">WTPEEFNAGRRLVSFWRNIGNNVVTCGFSLIESWADDNDDTLTISCIYWQEQDAFYYTSVDCIRLLEYLVDGEFTQQEKNRVRRNLEEFHPLTLGKTKSETSRFFRMIMGYPGPRPRNIEKDLKVFPWDTLEEALRKIIIHYTASYSSTATVHQSTHRSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BE90</accession>
    <name>A0A163BE90_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_62066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299061.1">
        <property type="nucleotide sequence ID" value="XM_018440896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BE90"/>
    <dbReference type="GeneID" id="29001802"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_62066"/>
    <dbReference type="InParanoid" id="A0A163BE90"/>
    <dbReference type="OrthoDB" id="2267507at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="669" mass="77686" checksum="D7FA85C704C07979" modified="2016-07-06" version="1">MLAYDIPFEILSKIAILLSVKDKIQCILTCKAWQSPFQDVLWDTISVFSKEKVREICDSDIKANIYKQNGGRVKLLIFGRRLRVSDQDLNTIQHRFKNLQSFCAPDSSLSSTEFGKIADWKLWNSLKELDIFIPVLDKVRSLKESLKILSNLPSLRRLHFTDGGFEDSPIYTLRDIEALHTHLPKLESLSIQMVLAPLEPEDIQLAKNTIPANTLTVLEIKLEFKDYRWLYYFARKYYNLRTLSWDSMHDMDIDDFKDSLSHMLSDISPVFPHLNSITVSSICCSEQKQATFWRIFDISKSTIKDARFLFTGVNDGKVLLEEDVKGCIELCSRTLEKLSVTCDVYAYNSDTISLSFNTCPRLVELYLDVRFLPIELDTLLDQCMSLKSIKLSVDSPSVSPSAFNDIMTHGVGFIELITSKLDTSILKYISFRCRKLYHMRLCDVLVYGPISQETGNIYIDMSHTHFEFLHLDQVHFYPSNKPYCMMNGNKPQDKNYLPDMRTIPVRILEICQQKNGGHDKMTPSIKDKYKQPSIESIWLHTYHCPEAFYPWKSVRVLKKREVKMAKRYFCGFQRKSTRDYVNMTRENAMIEMVLRHEWKSNLLRGYVTFRCGDIKKYRVTGHTSVKVDCGCQLLIAFGYIQRILSMSLGILKKLRLSQKIFYQEPSVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163D3M7</accession>
    <name>A0A163D3M7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_150653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286520.1">
        <property type="nucleotide sequence ID" value="XM_018432530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163D3M7"/>
    <dbReference type="STRING" id="763407.A0A163D3M7"/>
    <dbReference type="GeneID" id="28993436"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150653"/>
    <dbReference type="InParanoid" id="A0A163D3M7"/>
    <dbReference type="OrthoDB" id="2286148at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="840" mass="92803" checksum="0CAB5B36E600C129" modified="2016-07-06" version="1">MSVALFTFILDTTAHKKIIDAYPPIQDMIYSPPATLPVALAQFKPHQNLRSLLVHTSASITQSRNELAMHHVHPPLPPPHPEIRFFDPACHILQAGIPISASQPMDIEPIPSHLVLHNQSPPTPSNPDPNRFVSCGIISDRFQIHFNLLSPLLTHSRPTIPMDDSQRHLLCQEIAKLLHKKGIEPAPLNSPGFNGPVFVIFKKNGGYRPVFNLKHLNKHLTAPHFKIETLQAVCKFSSTVFGSHAAINDQAGIPGVASEPEEVVSPTISLPETKLYNLCQSIRQLITNVSPSPRLVYSLTMRIQAATIALFPACLYTQHLIWFKNKHVHQNLGWDMRAILDKVVLWAPTQSMDTGHMRKPRSRWLTCLPSNGTGHNDLEMVYPPWSLIGCTAHCREGQCHCRSGISPDFYEDPLETLQGNIQYDTVDVVIQTLGFDTGTTQCGPLPRSDHSSSSHVCVLAPRPKGNSFGCNVHLLEPIEQLLSQPLMKPDWPVSAQDMAGELEDDLGGSNLAECHMISSSPEDVGGSSPNYGQSVHSFRLLQNPMAVEELNVEACCIQTIKCKFNNTGLTNESVLLLIDSALTNTLTNRIYQWGQHLFIATIKNHHTAALKLHINPKSLCCHEDVQTVFSCLALQAPPLRQTRPSIDFASTLDHVASIVSATSTSLTPLSRKTAFLIVMTAFLHLSNLARLQLLSARVDISSDADYSRASTARPPQHLFVNAHQPMIPVQISTISSWLRSLLQLSMHESVLVQSIAFTLVLEHDMSLNNIVTLGNWSSCEVFQQYYSCNHTSSADFTNIVLRPSASVLVSGLVVPTIREQGRHGPSLPPTHTCNDQSMIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163D5C7</accession>
    <name>A0A163D5C7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_172711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286900.1">
        <property type="nucleotide sequence ID" value="XM_018436860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163D5C7"/>
    <dbReference type="GeneID" id="28997766"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172711"/>
    <dbReference type="InParanoid" id="A0A163D5C7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="201" mass="23519" checksum="2825C417D9AEBB4C" modified="2016-07-06" version="1">MNRARRGLRVTATKWFEMGTKKYINKQGGLVNSKRRLPSKNTVHLGLAIFGNTFLLNEYVKTSYAKSINSNKTVLISRIPVLFNRPRLYRAIYYCNAFAKYISYFLLNTATPKTQKYYIQGFWLGCTKIYRRRFMALIDVQEMFVQFRISVCICVCVVLGVLNERKILCLTFLRQALKKMIFGTPVYFLCGYVRKYCGKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DHF3</accession>
    <name>A0A163DHF3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_182185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289280.1">
        <property type="nucleotide sequence ID" value="XM_018438584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DHF3"/>
    <dbReference type="GeneID" id="28999490"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_182185"/>
    <dbReference type="InParanoid" id="A0A163DHF3"/>
    <dbReference type="OrthoDB" id="2207060at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="98" mass="10894" checksum="DB3243EC1E8DC84B" modified="2016-07-06" version="1">MSVDKRAFHASAPVPPPVYHTDPYFEMTDQSPPPPAYRAHHLSQYAIHPSQQPDVYYYQPTPPPQSVLVHSRPKKGNDACCLGCLAALLLCFGIQECC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DLD0</accession>
    <name>A0A163DLD0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_68627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290150.1">
        <property type="nucleotide sequence ID" value="XM_018441982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DLD0"/>
    <dbReference type="GeneID" id="29002888"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_68627"/>
    <dbReference type="InParanoid" id="A0A163DLD0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="129" mass="14476" checksum="F6664AF7870751AE" modified="2016-07-06" version="1">MLAKNGTIYGLVESTCHLPPENFVTLRLAKKQIGLASCTKKWNKGIVTNVAPKREGFHIKQEVFSLNEHSIRHNETAQILAGLIKPLTHACHLLFDKLAICAPSLRSKAFVSRSYVIYKLYDVDEQVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163E5F1</accession>
    <name>A0A163E5F1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_63019</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294820.1">
        <property type="nucleotide sequence ID" value="XM_018441057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163E5F1"/>
    <dbReference type="FunCoup" id="A0A163E5F1">
        <property type="interactions" value="508"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163E5F1"/>
    <dbReference type="GeneID" id="29001963"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63019"/>
    <dbReference type="InParanoid" id="A0A163E5F1"/>
    <dbReference type="OrthoDB" id="541710at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003865">
        <property type="term" value="F:3-oxo-5-alpha-steroid 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016095">
        <property type="term" value="P:polyprenol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039698">
        <property type="entry name" value="Dfg10/SRD5A3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624">
        <property type="entry name" value="DFG10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624:SF0">
        <property type="entry name" value="POLYPRENOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="178"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD76780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="303" mass="34579" checksum="A0CD85947952E660" modified="2016-07-06" version="1">MYLIIVLCGCLAILTILSFVSKHIALLRSSVLAYGKLDYTADQPLTAMARWIKNITVPKTWFCHFYAVGLMAAIECIIEITLALQWKVFGPVLTVLRLWDTPQGSRHLGLGECLVGLGLMTIHLARRLYESMMIERPSANARMHFSHYLAGMGFYGAMVIGAWLEGAANFGIWQPIKVEPFTLPWTTIPSIGLFIYASYHQHTCHKILASLRTPKTRNAYVIPRGDWFENLVVPHYFADILVYVSLWILYQGRNWTLTFGLVWTIVNLGVTAGETDQWYRKTFGKRYNDAFPRSRSLLLPHIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EBK9</accession>
    <name>A0A163EBK9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_164689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295840.1">
        <property type="nucleotide sequence ID" value="XM_018435059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EBK9"/>
    <dbReference type="GeneID" id="28995965"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164689"/>
    <dbReference type="InParanoid" id="A0A163EBK9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD77800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="139" mass="16274" checksum="91D357EA793DB573" modified="2016-07-06" version="1">MTSLVKMEPINQPLELVIFKRIYLIHSQTLRQILFKRDNEFYDWLVRNQTMVSYVREKLVFLKTKCVERLYASPYITMVVNWTGRFSFIFKINDVGSKIIGRVSCTIKYNITPGMKRENGILILGVVFLAGDLLVMDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EDS6</accession>
    <name>A0A163EDS6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_141976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD78110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296150.1">
        <property type="nucleotide sequence ID" value="XM_018430713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EDS6"/>
    <dbReference type="GeneID" id="28991619"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141976"/>
    <dbReference type="InParanoid" id="A0A163EDS6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="314" mass="35225" checksum="AF9D1A29E541F68E" modified="2016-07-06" version="1">MTNTRRERAIALRPVEITNQQLMEILSTVRADMSTVKGQIGNVEQTLTNMNGRIGVLATTSTNTISAIDSLARTPLAAPVRAELTVAAPVVISNHEPTREESNAVYAHIHNLMWKRKLSLRTPENILANNLKPRWDTNVAFNKSPNREIAERLLSNLEHRFGSSSMRRSDLQKRLHTNFTSRTRRERMSDDEIAETNALTRRAARADDNECCRVLAYKDNKEAIDLVMLRDCANTLQKAVMSDGESADEMDEDGIKHVIHICNRFIALVDTYAVQAMGSSANQRICRITTCVSNSAVPDNISPNFPRWALRDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EFD0</accession>
    <name>A0A163EFD0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear pore protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_163469</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the nucleoporin interacting component (NIC) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296390.1">
        <property type="nucleotide sequence ID" value="XM_018434804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EFD0"/>
    <dbReference type="FunCoup" id="A0A163EFD0">
        <property type="interactions" value="1177"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163EFD0"/>
    <dbReference type="GeneID" id="28995710"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_163469"/>
    <dbReference type="InParanoid" id="A0A163EFD0"/>
    <dbReference type="OrthoDB" id="1918363at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007231">
        <property type="entry name" value="Nucleoporin_int_Nup93/Nic96"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93 NUCLEOPORIN NUP93 DEAD EYE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04097">
        <property type="entry name" value="Nic96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="4" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD78350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="893" mass="103778" checksum="6E5F80E5630E5753" modified="2016-07-06" version="1">MWCALTVYQVEGQECIQMEQTFANLYEASKLLANPSRRNPQEILQRSFSQVIKETKDLEKTIPVDEESIAKGRAFFAKLGFPPVENFDVFGNIKINDSEGPSRYLNITDVEGHLQEHRDKMIIETIESVQKKARFCTISDFEEIRNKAMKEYRNNIEMDNRIAEERDRILGGNNPDHPMEYASEMYTKENPIKKRVLSYANVVQSLNGQRLQNKDFNVIAGFEKLAEVDCENNKMVGTEPHNVWNLLAWLAGEGNDISEGRREGNYMKAYLSKLPNTPESIELSHHLTNLARQWFERQFVRFVDMFLLKRILTANVGGNPEFGHRLKAFIKIQFKTDDQWNIQNLELAEDFPKWVYIYFLIRSGHFKNALVYVTEIAEKYPQDKKFMKYLEEYVENPHHLLSQATRKEIEYEHMLLKNNGNSVDPYKLALYKLLGRCDIYEDHVNGAINTLEDFMWFQLSLVRENIPEIEYGHGKYTLEDLQKRIVASGPSTFSANGANPWDYAIVLISSLQFERAVSHLYQQEATRLDAVHLAIACAYYGLLRIYTKPIQTDDNIFAISAKNIPEINFDQLVYRYTKVYVFENTKCILNYILLLSLFTPHHGFPNNSMVEKAREYIRRLVLFTKSFKEFLGEATDYGGRKPGLVDTYKALLGITTEADMVNYIYIPLVRSCIEAGLYTDAVKICEVGSDYNEATNILINQLESSINLPILDPPRLNPEDKKWNDELVKFSRELLTRYKRTPNIKCNIPLSKTYTVDTLLNILHFRELYESGRYDDAIQYMLRLNVVPLHDENDNVCQTLRQLKSGDKVIVKCIPKIVRILVDALERLHDCKCTHKDGSRDYDAEHENIRNCDRYARILFRFTGMADNDMLGELVYNEFLDLLMEFNQGVPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EPZ8</accession>
    <name>A0A163EPZ8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_161389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298790.1">
        <property type="nucleotide sequence ID" value="XM_018434391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EPZ8"/>
    <dbReference type="STRING" id="763407.A0A163EPZ8"/>
    <dbReference type="GeneID" id="28995297"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161389"/>
    <dbReference type="InParanoid" id="A0A163EPZ8"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="444" mass="49525" checksum="6368492BFEAF991A" modified="2016-07-06" version="1">MASFVSSLFQPWADKPSTFQPIQFSPQYPPYDTQHQPQSQSQPQAQPQAQLQIQSQPQPQPQPQPQPHPQSQSQSPQSWIADVGLLVDKLRDDAASMITSKSIHTMSSLDRKSIAQGMRLVSIAADEYDEGNEALGLEIYLSGIDKVLMALPNKPDEKTKMALKEKLSSVQERVGIIHLATLHNNPGSLSNLSEFPPSFSYSPSSLPSPSPSPLSLLSPVLNTFWSYRPKSICSNQTSPEPTSRFKRFSQRVIDTSVSFAVVQERVGIIHLATLHNNPGSLSNLSEFPPSFSYSPSSLPSPSPSPLSLLSPVLNTFWSYRPKSICSNQTSPEPTSRFKRFSQRVIDTSVSFAVFIKQSPLPDLVYLVFENLLRFILWADHRWQVHQKIEEVGMICVKALLRADERYHIHEYASEAAYLLVAASLKALVAYKEAPTYPHTISLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JK74</accession>
    <name>A0A167JK74_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_175456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441005">
        <property type="protein sequence ID" value="OAD66159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284199.1">
        <property type="nucleotide sequence ID" value="XM_018437490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JK74"/>
    <dbReference type="GeneID" id="28998396"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175456"/>
    <dbReference type="InParanoid" id="A0A167JK74"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD66159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="104" mass="11646" checksum="376A2DBDA3707341" modified="2016-07-06" version="1">MKETHSSSHSDAPSSQQSSGLARVNEHPSYERAIPQELPSHATVIAMIISWSAKKFFAFVKEIIIPCFTVNVLFLCPFVLGTSNKIFHPKYNKLAKQEVAEDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JT70</accession>
    <name>A0A167JT70_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_71912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441001">
        <property type="protein sequence ID" value="OAD66658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284698.1">
        <property type="nucleotide sequence ID" value="XM_018442558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JT70"/>
    <dbReference type="GeneID" id="29003464"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71912"/>
    <dbReference type="InParanoid" id="A0A167JT70"/>
    <dbReference type="OrthoDB" id="2258660at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="108" mass="12082" checksum="71428B628B2C7BDB" modified="2016-07-06" version="1">MSKTISLLAGVIAVSAITYKYTNDIQHDRQALRQRINGGPIKTQDVNTLEPLPIVTQSQVYLSQRLIPSLKDSWNAHVTKAAHAVIYSDAPNKIKKFWVKNVLGNRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JTH7</accession>
    <name>A0A167JTH7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CCHC-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_174969</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441001">
        <property type="protein sequence ID" value="OAD66677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284717.1">
        <property type="nucleotide sequence ID" value="XM_018437382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JTH7"/>
    <dbReference type="GeneID" id="28998288"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174969"/>
    <dbReference type="InParanoid" id="A0A167JTH7"/>
    <dbReference type="OrthoDB" id="427960at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD66677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="940" mass="104747" checksum="8A4A10AF9E9179F3" modified="2016-07-06" version="1">MALSTNTPEPPGVKNPSTTGSSPPLPTSFTPISPSSTPLYSQVATQNALPLLEKQPHVIFSSTNNTTSRTWRVGSSKFSVFFTVPPKSSPKFDPFWRALLSAYPREVNMGITLGSRSSPDTCELHLPTSADCERACSQPLVVGDSSFPAQPAVPIGTIVRRVFLTKLPRVPYHDLATQLAKCMSPFGKVREIAIHESYGFFDGSGYVVLANTPTDDVPSDSLTYQIAYDDTQKILGKWPSMGSHCTYCKEMGHDVAKCTKRPAETRTCFGCNKTGHLQANCPYITDPSKTSKTSNKRSRHPNRNSKLDRPIIAPKPLIPTELSLIYGGSEASKHNPRQPALHELSKLSPTKTTFTLPTPTETPTSSGPRPRSRSVDTPTRGWDKEIDDRMITNLMDRDEARTLRLQGLPKVGHPESRAFFIRHLRSQGIDILALQETHASSSMLQSTFDQQFRSSSSLWSPHCGVVCLSLHIIFTDPLFSPCGRCITTTITHVDNNFSPFRIGVIYAPASQTPRYRFLASLLSTPDLIPPNPSNFILLGDFNHAIRSHYALGRRAPADWLQFIDTNMTDCITPRGQHPQPTFHRALSSTTIDYILASSDLHPRTTDPQVSYIYQKWSDHCLVAVSLSLPSTKSSGKGLWRANPRLAQSLSFRTDLNTLLSTLVPALRADFSPQAQWDAIKLEVIRFTFCSIHGSRSLSFRGRATIMNSLVLSQLWHALRVVSFPSAFLDRVRSIVRGFFRANSFPPIAFETLCLPRLQGGLGILDPGIQQCALQLRWLKPLIRNPLLPHGLVPQWFSSLLRSDVPTVDPLLPLLFPDCRPRNHRTLDSPLHLVLKAMDTLPRNSDRVVLNLSSCLILPLSSMISSMPSHPPYRPAWRDLRVHHLYQIESNLDILTPITPSRPLPRSVTLNRILNRIRDHTMHFLEVELLPSPQVLCNSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JWR8</accession>
    <name>A0A167JWR8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_70179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441000">
        <property type="protein sequence ID" value="OAD66827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284867.1">
        <property type="nucleotide sequence ID" value="XM_018442227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JWR8"/>
    <dbReference type="GeneID" id="29003133"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70179"/>
    <dbReference type="InParanoid" id="A0A167JWR8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="193" mass="22792" checksum="B34E6478054720D7" modified="2016-07-06" version="1">MAEAAYYISRRRYIRKELVDSYNSMGPVEKDRYYEMAKENFVTLHQESSVLEVNLGAKSILTIMNTIKLSVNYNNLFLFWESGTSYCQDIGRLFLLKLLGNVERRPTTIAANEYRNKINKRLITLFNEETEELRKAFPWKIVKEHKDIIRVVRWPEKMPFKPLSSIKDIEKEILVDSLDKGLISFYYYLEGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K533</accession>
    <name>A0A167K533_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_118479</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285339.1">
        <property type="nucleotide sequence ID" value="XM_018428634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K533"/>
    <dbReference type="STRING" id="763407.A0A167K533"/>
    <dbReference type="GeneID" id="28989540"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_118479"/>
    <dbReference type="InParanoid" id="A0A167K533"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF2">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD67299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="318" mass="37797" checksum="5CBAB48877D2C011" modified="2016-07-06" version="1" fragment="single">SEQEAIAETIVNFQDKFNKNFNYPYVFLNNDLFTDEFKTAMKLAAPNAEMSFGLVPQDHWGYPPWVNETLAAESRKQMDADNVFYGGMESYHHMCRYQSGFFFNHPLLDNYDWYWRVEPGVKFFCDITYDPFLYMQKNNKQYGFVVTLTELKETIPTLWKTVREYAYSRRINITSNPQLLFPFFEDEQGDYNLCHFWSNFEIASLNLWRSPAYRDFFNYLDQTGKFFYERWGDAPVHSIAAGLFLETDQVHYFEDIGYQHDLYRHCPSTASGKGCRCDCPEGTNDKSIDHDQYPDSCLPKWKNWVETSKARKAHWMWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K827</accession>
    <name>A0A167K827_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_183512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285496.1">
        <property type="nucleotide sequence ID" value="XM_018438782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K827"/>
    <dbReference type="FunCoup" id="A0A167K827">
        <property type="interactions" value="639"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167K827"/>
    <dbReference type="GeneID" id="28999688"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_183512"/>
    <dbReference type="InParanoid" id="A0A167K827"/>
    <dbReference type="OrthoDB" id="5572108at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10206">
        <property type="entry name" value="ASKHA_NBD_Arp8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="585"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="87"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="621"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="632"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD67456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="812" mass="89376" checksum="FC6A2953476FD5B8" modified="2016-07-06" version="1">MADSPHSNTFLKSLSQKKYAWMQTPSATFTQPRTDSLKPEPRKLKEDTRPAKKARQAKRHGSLDQDMKIVIKSEPITKRQTSSSAISPLYSPTTPPSAYSSVFTTSNNNNNNNNNNNNATTGGSSSSLPPHSSLHDDLLPPKSPTFTKSEELDNEADKVPQPHFKYTTFPVKGFNILPTRNITSTFVKSDVTYFPGNKAGSEAIMPDAKEEWADTIVIHPGSRNLRIGLASEAFPKTVPHVIARHIAQPIPEIPDEEVDEENEEAIEEIKGELKWRMKSAKRRAVPNAEGQVVGFNTQAYQELIPDHNDPYKVEWTEINPAKKPDHFVGEKALNLPIAENSDYKLFYPWKHGTFNNQDYTSLQAVMGDLQTIWTDTINTELEIEGKQFEEYNAVLVIPDIFPRSYICDLVTVLLRYMKFRGVLVQQESTSATFGAGVSTACVVDIGAQKTNIACIEDGVCFVESRAMISMGGDDITKTFMSFLLVNRFPYADINLKRSHDWRLAEDLKKRWCTMNEADISIQVYDFFVRAPHKPTKKYQCKVYDEVFLAPLCLFFPAVLNDKEKTARKTKWISSNVVEDIGDEFQASQVPGGGSGSGNGSGTSNSVAPPSTPQGQRAKPWTSNNSNSNSNGNGNGNGNGNGGTTNGLPGPSPKHTSISTPTPASASASASAPTPNGSETPILGPTVVTSKDQEHVVFPLDVAIAQSIQGASGASEERLKRFFTNIILVGGGGMIGNFNRVLEDRVLSTSIAQSLYIEKVEVLPAPRELDPRLLVWKGASVLSKLEIAKEMWIGLEEWDQVGARCLKDRTLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K9J2</accession>
    <name>A0A167K9J2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_79490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285586.1">
        <property type="nucleotide sequence ID" value="XM_018443469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K9J2"/>
    <dbReference type="GeneID" id="29004374"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_79490"/>
    <dbReference type="InParanoid" id="A0A167K9J2"/>
    <dbReference type="OrthoDB" id="10429119at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="175" mass="20133" checksum="8C4CE467DB24E1D4" modified="2016-07-06" version="1">MKITIVDSRYNIPTRYLRLRIPNQRGRLLFLWPAISKFNKYIKVGFRVNRMTWNMWHRQSLTQIKPIAQRHSALLLSSNTRSSSQSAISTLHTSETIPRQSISNSTNDKTESAQPNDDSISESNSSSRSSSSYTPFFESQLGNTRHSLSGETSGLRRCKTHYANLYQYFAHNIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KD32</accession>
    <name>A0A167KD32_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_79064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285839.1">
        <property type="nucleotide sequence ID" value="XM_018443419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KD32"/>
    <dbReference type="GeneID" id="29004324"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_79064"/>
    <dbReference type="InParanoid" id="A0A167KD32"/>
    <dbReference type="OrthoDB" id="2263377at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="356" mass="39916" checksum="DF17E7768B63BDE2" modified="2016-07-06" version="1">MEYFKLDNQKNDPVKKYFSEHPVSEWSYPEFEAAFIKNKPIKPNANKMKNAYLNMMKTPKNTGNIPEDPSLSLGAYTPPRGIQCHDWCMDIEASPPSDGLSSLKLSGKMLSDGCESDDILDIHTAQVLIYILPIFINGPPGCSIEDSYVHNYLSPLLVTVFGSDPLLSMKWANSQLMSSDSKAYKPDFLVYNLSGSVKHIISISEFKHVDQNSYVESDLVKLAKQTKFTMNNLISSGVVEPKVCGIHREGNNLHTYVMDLVSPKVYRMISVAKLKLFGNLDQITLLPRILTHLISLKNFACESALKIETSVISTGSTLKQPAPLPTLALVIQRFLFSDPCYDEAKEMDDLVFFCQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LHC1</accession>
    <name>A0A167LHC1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_70621</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288499.1">
        <property type="nucleotide sequence ID" value="XM_018442307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LHC1"/>
    <dbReference type="FunCoup" id="A0A167LHC1">
        <property type="interactions" value="449"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167LHC1"/>
    <dbReference type="GeneID" id="29003213"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70621"/>
    <dbReference type="InParanoid" id="A0A167LHC1"/>
    <dbReference type="OrthoDB" id="201752at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13778">
        <property type="entry name" value="Aar2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13777">
        <property type="entry name" value="Aar2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.20:FF:000001">
        <property type="entry name" value="protein AAR2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.550">
        <property type="entry name" value="Aar2, C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007946">
        <property type="entry name" value="AAR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033648">
        <property type="entry name" value="AAR2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038514">
        <property type="entry name" value="AAR2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033647">
        <property type="entry name" value="Aar2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038516">
        <property type="entry name" value="AAR2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689">
        <property type="entry name" value="A1 CISTRON SPLICING FACTOR AAR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689:SF4">
        <property type="entry name" value="PROTEIN AAR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05282">
        <property type="entry name" value="AAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20981">
        <property type="entry name" value="AAR2_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAR2 N-terminal" evidence="3">
        <location>
            <begin position="13"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="AAR2 C-terminal" evidence="2">
        <location>
            <begin position="187"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD70459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="360" mass="42685" checksum="8F31DE24ADEB97BD" modified="2016-07-06" version="1">MDQQTANALFDHGAFLLFLDAPPNLEFGIDYHAWTIGPLFKGVKMIPPGLHFIYFSATSNEGLQGIRTGFFKYFESKEVAVREWNTHTEDLREERELDPEQVERYKKNIRDFDRNMGPYPLDPPTYYQRWRTLTEHITPGLVRRILPNDGKVSHLPRKSPEPLDDDVLSVKDKRVGKEVEKEEGMEFTPFDLRQSFPKNATAYEITKWSIDKSWLARDLLRRVYHDDHLVMLGEMQLSFVCLLMAQNFSGFHQWKQMVRLFCSCQEWMEESPGVFIDFIDTFEHQLEECPEDFFRDILSENNFISSMLQEFRKNIPLHEFELGKRFLQLKKFLVSRFKWELPTEEDEEDEDAPMVVEMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LLA4</accession>
    <name>A0A167LLA4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_171442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288736.1">
        <property type="nucleotide sequence ID" value="XM_018436600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LLA4"/>
    <dbReference type="GeneID" id="28997506"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171442"/>
    <dbReference type="InParanoid" id="A0A167LLA4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="123" mass="14405" checksum="009D7D50CBA2249C" modified="2016-07-06" version="1">MCERVSNSLIKLRFASDISYLIIPFCFPVKIYLTGIQTEYLTFMFYEDGIHGRIEDPIKEIIMSSQGYCRYRVDSKSLNNESRLFDKSFSFKQIYLIKSLSLRIKYGLPSSQRHSGYSDKSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LX29</accession>
    <name>A0A167LX29_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_66457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289306.1">
        <property type="nucleotide sequence ID" value="XM_018441644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LX29"/>
    <dbReference type="GeneID" id="29002550"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_66457"/>
    <dbReference type="InParanoid" id="A0A167LX29"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="542"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="641" mass="68657" checksum="27A36EDDF2FE1DC0" modified="2016-07-06" version="1">MISYPIQLALQTLCLASAYFCALLFAAISSISVPSVFNMGLFSNRMKVIHEGKTAIEHCNINTDTNIDHMSDDEGCLQSFRTSSEIFSSGSCRGGSLGDALRPISCFGVSSEINGAGDVEGLSSSTSVNQQNSICHRMNSTVCEDDKRSHMEQVAYIPVRHENQGLKRLVRTRLPYYGEELEEQMFEVLVPKASPSKLIGSTPEPLKDGIQDEPHSICYDKVHTSVSVTVCSLALPCSPEQGSFTEQKPSFSLVGELPSSGQEMILIEISNLVSLFGSMSIEDTSEDLRAGQNLSVYTAQQVGAAGVEMASAMEDCWYGENTVWSEEVPQCPALVGGLFAFGQQESMDFVSTFDAPLEQMLTDADEEDTNCAMSIISEPESSEMLDVEYAGVVVAGVSTACWYNINDELAMVPEDLYGDSLMDLAVEVVPGIKGNLDHYQDDCLMYWDESLVSKASPIMAATMFSVSGATTMFPASGAATRLSVSGAATMFPVSGATTMFPASGVACPFPLEQVNITNKGATCVPQQVAEDLVGNPEEGPRLPSSPLLPGSDSGAGLPGQSGMLLPENKTPEPTTIPGVVAWLTTAPESPEEVLEGEEDDDDDEEDSDKGHEDDDEGVTLQDSVLADLLAELEESDFDDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LZH4</accession>
    <name>A0A167LZH4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase II</fullName>
            <ecNumber evidence="3">3.5.4.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_100690</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 2 phosphate + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="3"/>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289454.1">
        <property type="nucleotide sequence ID" value="XM_018427602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LZH4"/>
    <dbReference type="FunCoup" id="A0A167LZH4">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167LZH4"/>
    <dbReference type="GeneID" id="28988508"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_100690"/>
    <dbReference type="InParanoid" id="A0A167LZH4"/>
    <dbReference type="OrthoDB" id="5569761at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001591">
        <property type="entry name" value="PRK00393.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF29">
        <property type="entry name" value="GTP CYCLOHYDROLASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="10">
        <location>
            <begin position="91"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD71414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="277" mass="31448" checksum="8A773F128BC4B76A" modified="2016-07-06" version="1" fragment="single">DVQCQVRARIPTMEGGEMHLFLYKNNKDTKEHMAIVYGDDIRSSSLDKTWENETIMNRVVRGAYYGRLEEIITDETQYTQLNAKQWARLAQQQAIAKEAWRPVSEAPLVRIHSECFTGETVHSARCDCGEQLDEAMRLMQQAGRGVIVYLRQEGRGIGLLEKLKAYNLQDLGHDTVAANLLLDHPADGRTYDIANDILKDLGLSEVRLLTNNPDKIEQLEAFGDIKVVDRKSMVPQSWSSSPPLSHTPQSTPKKELDRYLAVKVTKMRHMLDLPTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M208</accession>
    <name>A0A167M208_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_182033</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289587.1">
        <property type="nucleotide sequence ID" value="XM_018438552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M208"/>
    <dbReference type="FunCoup" id="A0A167M208">
        <property type="interactions" value="701"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167M208"/>
    <dbReference type="GeneID" id="28999458"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_182033"/>
    <dbReference type="InParanoid" id="A0A167M208"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000026">
        <property type="entry name" value="Seryl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="143"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="272"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="288"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="359"/>
            <end position="362"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="9">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD71547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="444" mass="50857" checksum="3CF588B417ACE529" modified="2016-07-06" version="1">MLDINLLLEDRGGNPDAVKESQRRRGDSVEIVDEIIALYKEWVKIQFQSDQKNKEINAVQKDIGKKFKAKEDATPLVKQKEQLQKDKEALIAQAKESESNWKEKLSTMGNIVHSSVPTSMNEDNNEIIRTYNHNNVVPVKRTDILSHHEVLSRLDGYDQERGANIAGHRGYFLTGVGVDLNLAMINYGLSFLARRGYKKLMTPFFMKKEMMAKTAQLSQFDEELYKVTGDGDDKYLIATSEQPISAFHANEWFEKPAEQLPIKYAGYSTCFRKEAGAHGKDTWGIFRVHQFEKIEQFVLTDPEKSWEMFYDMIGHSEDFFKSLGLSYRVVSIVSGALNNAAAKKYDLEAWFPFQGEYKELVSCSNCTDFQSRSLEIRCGVKKMSDREKKYVHCLNSTLCATERAICGLLETWQREDGLEVPPALVPYMDGRTFIPYEKKLPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M3Q3</accession>
    <name>A0A167M3Q3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_147450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289737.1">
        <property type="nucleotide sequence ID" value="XM_018431867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M3Q3"/>
    <dbReference type="GeneID" id="28992773"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_147450"/>
    <dbReference type="InParanoid" id="A0A167M3Q3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="209" mass="22905" checksum="979C22F0F13CC469" modified="2016-07-06" version="1">MGTTRINSSSSFKTIGSGLQKGIWDDRVYIMDREHQQEQVEAGSWCGKPGSGSSSAIRWSNPFAVDPIAASWHIVSARSLVVYCRWSRIPPTGDQGPFRPVIKEHFAVPSPSLQMMLPIPKQVPLLTKQILSIKPYSALSTPIMRQIPKPESCARMTAARTNRGAFLSKSKIWAVPPSLKAKSISKKGSNAKFQKQSSTPKGSNPKTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M548</accession>
    <name>A0A167M548_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_72701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289869.1">
        <property type="nucleotide sequence ID" value="XM_018442698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M548"/>
    <dbReference type="GeneID" id="29003604"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_72701"/>
    <dbReference type="InParanoid" id="A0A167M548"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="157" mass="17917" checksum="AFCB170575713CC9" modified="2016-07-06" version="1">MSCSNRLVWRRVCDLVDEAPDNEKACILRRYVNREEKFGNTVDNDTRKAKSFQSSLEILRMYTIVRFCLVKQQTNGVNGGELCLFHSYAAHKPIIASDLEAGVLRKFSKRAKALISVLINEIGFQFFKVERSAFIGSRDKQVELQDGGNIPCKRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M8T1</accession>
    <name>A0A167M8T1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Calcium-channel protein CCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHYBLDRAFT_147120</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290187.1">
        <property type="nucleotide sequence ID" value="XM_018431798.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A167M8T1">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167M8T1"/>
    <dbReference type="GeneID" id="28992704"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_147120"/>
    <dbReference type="InParanoid" id="A0A167M8T1"/>
    <dbReference type="OrthoDB" id="416585at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000093">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="616"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="690"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="725"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="765"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="821"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="865"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="896"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1157"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1240"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1285"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1414"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1497"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1532"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1563"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1621"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1711"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="18">
        <location>
            <begin position="321"/>
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        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="18">
        <location>
            <begin position="702"/>
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        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="18">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="18">
        <location>
            <begin position="1497"/>
            <end position="1744"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="68"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="153"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1950"/>
            <end position="2031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1955"/>
            <end position="1973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1984"/>
            <end position="1993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1994"/>
            <end position="2010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00067459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAD72147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="2031" mass="231283" checksum="6B8FC0D4D9FB7045" modified="2016-07-06" version="1">MSVPGHRQEGIFSAYGSTRSSNNPYRDLEPNDQDLPQPDILNHVPENAPTFLSFPAKDIAPETHLRRTFTRSKPVDQSDFKAAFEDGQVPPATTEERQEPEQPTKPRRAKRNRYRRPSLAESLSTTALMSEQSYIRTYDATDDVDYSDTAKLTANASGSGRDPSPPSIRPYDSTPVAPTQDMQRQQSQHNSLVSKRQSLIKVGTVIRRMSRRVVNVQNRGPLPKPLNIPKSTYDTMRQAARLEEEIPVVEEAIPLTPATPYRQPVDIESSQRQAGELDRDSFAQTLQMQNGSHIYLVDQSCGIFSPTNRLRVALANVLCWKWTETLIMMLIALHGSVLLAVGWGTDPNPKPPSQWGVQWNQFVLLGIFCCYTVAIIVRVIVYGLISNPIKKEGDIVPPLAFLRHSWNRIDFLSVIAYWIDLILLLTGQEIIGETRRIMVFKMLSTLILLRLLNITNGNKVILQSLKKAAPLLRNVLFFVLFFFIIFAIVGVQSFKGSYLRRCVWTKHKVIKQQQQQQIDGLIIDPEDSEDVQILQQYCGGYYVEEEEKPFLLKNGNEGPWSKGFICPNGLVCKETENPFGNTISFDNIFASMLIVMIIAGDQSWTDRMYDMMDAEYYFACLYFIVLVIVMNFWLINLFVAVINEMFAKVREDSQHSAFTTSKATPVLADADEGWSFGENMNGLAKVKKSALSGIVTVTRPFWIILVVVDLVVMGAKNNSMTSEQLAALDYAELGFTLAFLVEILLRLASQRRQLKKFFHEKMNRVDFFVAIITCIIWIPPIHNNRVAYAWLTGFQVLRIYRVVVAVPRLRVLMSRVLGSVYGLINLVFFIVLATFLCAIVAFQLFEGDLNDTGEEMRFFSIYNSFVALYQLFSGEDWTTVLYTAMEAGSKSKNSAIYALFLVFWFAFSNFVLVNMFIAVLMENFETAEEEKKKRQIQYYVEKTENAFVTDDPIVSRWNIYRYMKAKPKELEIKNMPTTLLLPVQKNAVREFMNEAAETSFAKDKKINKRVTQMDRSVEKDFLSKTKNFLGDLLVSKKNAAPHLLVNNPRKSLNIDAFNFEQFSTFYDHNKQGNSNDPQSMRYLFDSTSKETAASRVAEAVSHNLEERKANQQEFITAHPTYDKALYIFSQSNFIRRACQALVPPSRGERTFGRTPSYWHSLLFSFFIVSCVITNVVLTIYNSPVYAAENRNEEPKILILKYVDWAFTIIFSAEFVIKVVADGFFMTPNAYLLNGWNVLDLFVLITLYMSNFGNFAASTGLERVFRAFKALRALRLINLLEPAKETFTSILVTGLPHILDAAFLGLSLIVPFALYGQNIFQGLMFICNDDGDTITDKNSCMYEAMLGTAEPMAAETQIYQPRVWDNPYVYSFDSFWKSLLILFEISSGEGWIDVLSSSMAVTSKDQNPQQDNSQLWGIFFMVYNLAGSVFVISLFLGVVLENFAKRNGTLYLTADQRRWLDLKKLLSQMRPAKRPKTVPSGRIRRRCFELVVEKRGRFYKFMTIVICMNILFLCTDSDHDENVPGLTIAKGYVYLTFIFTYWLEIAIKLLGLGWSSYRRNLWNVYDLLVVIGSAIAVIATLGSSSHQINVESQKLFMTALCFKLVQRSDSLNQLFTTMAASAYQILNVFAVWFVVMTTYAIMFMEIFGLTKYGNQASTEHINFRSYANTMTSLVRYSTGEGWNAVMHNFAVESPNCVEAVNYLDSDCGSTGWALALFLTFNVISMYIFQAIFVAVVSDNFSYVYQIAANFSLKIWAEFDVERTGYITSKDYMSFWRKLDGMFNVRIYDRELSYKTLVKQCSIDGPVVNARDDPYRLNVDIDALNRKLDIIDKPVVHGRKHDLDMLYWEAAMVESPKGVSFNQMLLMLAHRKLIVPEHALLLDELLANRRKEEGIQTLINIDRVKGLIETIVLRKKFLAHLQAKKDASRQKHDLPSIVVDYDDVSLLRVKTIPEGSPVSSSPGTPASVTGDTNPFDTHIEEHSPRSSHSPSSISEQNQGDTEGDTTPSSSRNTIDHSPEQDIWLEMLQEEMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MAC5</accession>
    <name>A0A167MAC5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_146476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290314.1">
        <property type="nucleotide sequence ID" value="XM_018431657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MAC5"/>
    <dbReference type="GeneID" id="28992563"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146476"/>
    <dbReference type="InParanoid" id="A0A167MAC5"/>
    <dbReference type="OrthoDB" id="10537318at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="111" mass="12625" checksum="1FCAB06E899A8D6A" modified="2016-07-06" version="1">MSSFYNHNIHNYKNQEGNPSEEGIVQMTVASRVGRHTKCGNTIIKMLLRLIIEAKFHVKHVIGDSTRKASLGSNLHAEFCINPNMICFADTSAGHQFSLKYRDLKCVKERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MXT5</accession>
    <name>A0A167MXT5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHYBLDRAFT_155269</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292474.1">
        <property type="nucleotide sequence ID" value="XM_018433392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MXT5"/>
    <dbReference type="FunCoup" id="A0A167MXT5">
        <property type="interactions" value="589"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167MXT5"/>
    <dbReference type="GeneID" id="28994298"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_155269"/>
    <dbReference type="InParanoid" id="A0A167MXT5"/>
    <dbReference type="OrthoDB" id="1191041at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17961">
        <property type="entry name" value="DEADc_DDX56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF21">
        <property type="entry name" value="DEAD-BOX HELICASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="40"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="222"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="527"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAD74434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="569" mass="64628" checksum="137DA89F63DEBEB0" modified="2016-07-06" version="1">MANSSSSTETFETFDFDPRLARAVAQLNFTHPTLVQQKVIPLALAGKDILARARTGSGKTAAYSMPIVQKILASKEATLILVPTRELAEQVTGHINKLLVYSNQIVKVANLAGQVAPQLQRPLLAEKPDIIVATPSKALVHLEAHNMVLNESLENLVIDEADLILSFGYEDDLRKILSFLPKIYQSFLMSATFTKDIEELKDLVLRKPVLLELDEDDEEAEQLSQYVIKCSEFEKFLYTFVIIKLRLIKGKVILFVNDIDRCYKLKLFLEQFSIKSCILNSELPLNSRYHIVEEFNRGIYDYLIATDESELKGEQDSDDEDKKVEENEKPKKKAKIQRDKEYGVSRGVDFQNVAAVVNFDFPTSSKAYTHRVGRTARGGQRGMSLSFVVTRESMDTNKDNARGNNSHDEVVYKRVEKQQTEKKAEMKPYTFEKKNVDGFKYRVQDALKAVSKMAIKEARIKEIKREIMNSEKLKAHFEDKPKDLDFLRHDQALQPSKVQEHMKHIPSYLMPRVAAPNALAVDQASNPVASIGPNVPFNSDKRRRAADSKTNGKSHKRKADPLKSIKVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MZR3</accession>
    <name>A0A167MZR3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_145046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292654.1">
        <property type="nucleotide sequence ID" value="XM_018431356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MZR3"/>
    <dbReference type="STRING" id="763407.A0A167MZR3"/>
    <dbReference type="GeneID" id="28992262"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145046"/>
    <dbReference type="InParanoid" id="A0A167MZR3"/>
    <dbReference type="OrthoDB" id="2209375at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="455" mass="50805" checksum="69102BDCCFD7A03B" modified="2016-07-06" version="1">MPNLSTGPSGNDLVIRYSTNQEWSTNNNHSSTTRTSSDNLCRHLRHRLGSHLHCSVDSWLEETAFPILQQLALNVQIFCNKYNLKTILPVNPEKIWDIDSGCICRMGKYLVANLLELQAEPSSRCDQCFRTIVTNNRTIFTSTMEVDPSVPPKDQAESSQESSADDPKLSKSVLVANGNDANGRKTNDSANKPMVVLSHIDIVNKNQKKSGLSQTASTYIQGTVRNSSSKAYDWIWKKFSEWYQKMDPILNIEDYNPTLMICNCICVCDDVAPQSDDLFSITEPISGLTLVSRVPKEGKFKISRLRSLEDEPVLCPVQTLIISINCTQAKRTELPEDHSLFLAYVDHPVEKLSSALGKAVVGWIKTMIENLGVDTTLFTPHSQRAASSTRAKYYLKPNNQHEESSALVKIIFTANNTEKDSISGVEAKATTIVADTTHNRTVVKAETRDMMDTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N020</accession>
    <name>A0A167N020_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_61304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292679.1">
        <property type="nucleotide sequence ID" value="XM_018440787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N020"/>
    <dbReference type="GeneID" id="29001693"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61304"/>
    <dbReference type="InParanoid" id="A0A167N020"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007890554" evidence="1">
        <location>
            <begin position="17"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="123" mass="14667" checksum="025365BF862C0DED" modified="2016-07-06" version="1">MIFFFWLVSPFRELSYLSVLQLTKKTKKIGVTIKVYTLFRVDLSSQYHQVYKQKRLKVYYFPHSFVVSIEYLLFVACLNCLAPFTWHFVLDRVNIKLSGLQPACTKFCRAQHIKESRNSKYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N0Z2</accession>
    <name>A0A167N0Z2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NADH dehydrogenase 1 alpha subcomplex subunit 11 NDUFA11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NDUFA11_2</name>
        <name evidence="11" type="ORF">PHYBLDRAFT_124102</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292759.1">
        <property type="nucleotide sequence ID" value="XM_018428969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N0Z2"/>
    <dbReference type="FunCoup" id="A0A167N0Z2">
        <property type="interactions" value="155"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167N0Z2"/>
    <dbReference type="GeneID" id="28989875"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_124102"/>
    <dbReference type="InParanoid" id="A0A167N0Z2"/>
    <dbReference type="OrthoDB" id="2261329at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF0">
        <property type="entry name" value="AT05822P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD74719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="150" mass="15328" checksum="E039E5C58B2392B7" modified="2016-07-06" version="1">MGHSSQDHSRDPCPWVILNDLGGAFVMGAVGGGIWHSVKGAKNSPRGERLVGAVTAMKARAPVLGGNFAVWGGLFSTFDCGLKGIRQKEDPWNSILSGAFTGGVLAARGGAKAATVSAVVGGSLLAVIEGVGIAITRFTAESNRPVMPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N354</accession>
    <name>A0A167N354_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_61094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292894.1">
        <property type="nucleotide sequence ID" value="XM_018440749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N354"/>
    <dbReference type="GeneID" id="29001655"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61094"/>
    <dbReference type="InParanoid" id="A0A167N354"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="34813" checksum="FF3E40C65F587A83" modified="2016-07-06" version="1">MTKHIPTAPRQSNLCMNAVLNSTSAGVVAPIDTSTPEVAVDTAPEVQVAVTPIDHVLTLLAANNVSMQSLQENAKGVTDAITHLKNVLDLSNKTNEFLKNSVLQLMTANAKIKKAMTGQNSMMPSAVPADSSSSMDDDLDLGAKHHPLISKPNFVSTDLLKVAENNNRSAWSMTGTYGNKYNKTLALALFKYLRPQRCCTNVSKSVIMNIIKNNYQNQVRVFQTSAEKIMARNKAGRRRNRKKTISFKINFLTVLQTFISTIDELTVIRLKKNSESLKKHISYEKEVSIPENLAVTLPDWYFQNKSFFSCQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N7N3</accession>
    <name>A0A167N7N3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcriptional regulatory protein RXT2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_143506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293284.1">
        <property type="nucleotide sequence ID" value="XM_018430997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N7N3"/>
    <dbReference type="GeneID" id="28991903"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143506"/>
    <dbReference type="InParanoid" id="A0A167N7N3"/>
    <dbReference type="OrthoDB" id="2405722at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013904">
        <property type="entry name" value="RXT2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08595">
        <property type="entry name" value="RXT2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcriptional regulatory protein RXT2 N-terminal" evidence="2">
        <location>
            <begin position="87"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD75244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="373" mass="41004" checksum="9F0BE8A26F876F30" modified="2016-07-06" version="1">MDSSTEHPLSNLHSIGADRNLGSSTSTNTQQSAAPSAPLAHSVPAAKWIQDNEESDNDQIGLVPHNREAQFGGNKLRAPRKLAEESEYTKAGKKRTVVKRKKRRLDEEISDEEEDPYTLVNIEGKPNFFFHSILSPIESPTDIVRRPALRRIIQSRQVEGLAKTAMEFIEGEKNFNKILCRLCAILHHDDPRYLDLKFERTPEERRAKRHAGSKDNATKDIQENRAGGSGSGSVAGSGSGPGAGAGTGSGSGSGSGVGQAKVDQNGRNLSESETKKEDGGEPTSHMNEKISSMSVEEGPSSQSNDSVDAEAQEVVRRENINFSNEYLLRLQGARDKLYKAHMQKDALWSQLCTIADEQDRRQNYRDSSNIGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NJ04</accession>
    <name>A0A167NJ04_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_166015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294079.1">
        <property type="nucleotide sequence ID" value="XM_018435352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NJ04"/>
    <dbReference type="GeneID" id="28996258"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166015"/>
    <dbReference type="InParanoid" id="A0A167NJ04"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="141" mass="15837" checksum="2652D63C2C2E5903" modified="2016-07-06" version="1">MLSVEQLMDIEKYIAINSYPLFQTMPCDSSILDFLSIGISSSVDVLLIYPSKVQGVVMFSRKPFGVVFPHAHLSQTVGVEASFSFRALASPRNLVDTQQILYRGILSSPSEQFFNHVTRNMAGPLEPGLREDLRQIFNPVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NPY7</accession>
    <name>A0A167NPY7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 11">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1 11">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 11">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_109741</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1 11"/>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294464.1">
        <property type="nucleotide sequence ID" value="XM_018428133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NPY7"/>
    <dbReference type="FunCoup" id="A0A167NPY7">
        <property type="interactions" value="533"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167NPY7"/>
    <dbReference type="GeneID" id="28989039"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_109741"/>
    <dbReference type="InParanoid" id="A0A167NPY7"/>
    <dbReference type="OrthoDB" id="337870at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000001">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054608">
        <property type="entry name" value="SYY-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF0">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="TYROSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22421">
        <property type="entry name" value="SYY_C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Tyrosine--tRNA ligase SYY-like C-terminal" evidence="12">
        <location>
            <begin position="365"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD76424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="430" mass="47784" checksum="039D018CB24CB73D" modified="2016-07-06" version="1" fragment="single">LIHDLHISPEISQHTETSTAIYCGVDPTAKSLHLGNLVTLMGLLHFQIRGHQTIALVGGATGSIGDPSGRSSERIPLSEDILRVNVAGIEEQIHRFFSNGNKYANRRGFSGTGVTPKVLNNYEWFSSMNALEFLGNVGRYARVNTMLAKESVKSRIETTQGISFTEFSYQLLQAYDFWYLHKYHGCRIQIGGSDQWGNITAGIDMINRKKDQGESEEIEKAYGITIPLLLTSSGDKFGKSAGNAVWLNESMTSIFDFYQFFMKTADADVGKYLSMFTLLNQQEIDDIIKSHQANPEKRIAQEKLAMETTELVHGREGVQKAKTASQVLFGGDLSTLTGREILDAFKDDSSRLAKFERSKIESCGLDVLATLANATQSKSEAQKKIKAGGMYINNVRVIDPRYKVTEADWIDNEVCVLRVGKSSYHLIQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NYQ3</accession>
    <name>A0A167NYQ3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_142399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294934.1">
        <property type="nucleotide sequence ID" value="XM_018430805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NYQ3"/>
    <dbReference type="GeneID" id="28991711"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_142399"/>
    <dbReference type="InParanoid" id="A0A167NYQ3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="139" mass="16028" checksum="FE41FE1A04DABB84" modified="2016-07-06" version="1">MSDIDYPQLLDYYKIAYAMPNLISYHNARLSQYFVNNRITKLKSIDLLGQTYIGNNSSGKRGSLVQAFFRSSNGRTSSLYTRQIQDEGIAICLPEFSADNYHNILRVHRIHLEVAIAVDVTDMNEERMLIIPMPKKYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P1E0</accession>
    <name>A0A167P1E0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_158061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295104.1">
        <property type="nucleotide sequence ID" value="XM_018433725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P1E0"/>
    <dbReference type="STRING" id="763407.A0A167P1E0"/>
    <dbReference type="GeneID" id="28994631"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_158061"/>
    <dbReference type="InParanoid" id="A0A167P1E0"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD77064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="330" mass="37330" checksum="419B21E82AD153DB" modified="2016-07-06" version="1" fragment="single">MTIVLEVADTLKNSSSLKELLCLILLLGNFMNASSIQGGAFGMRISSINKLADTKASNISSMSLLNVLAGVTRREFPHILTFLDDLKNASQAARIMASFNDMSQQYAEMRMSLRQLEVELGSKWQGEGVQLEEGDRFLAVMNEHREAAANRFEDLQTLYLNMDAKWKSVMVFYGENPAVMRPDDFFSTFSEFVKNWKEASIQEEKYTQRMEREEKKKREDEEHKARMEAKKEAKRLAENTDGKVDTPQRVEGVDISEEATTGTEDDRKMMDNLLAKLRTGESEVRTRHARRAGRSREVQDNSDVMPALRPSTSTQPGALSAEALLRSLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PQ34</accession>
    <name>A0A167PQ34_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_154365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296377.1">
        <property type="nucleotide sequence ID" value="XM_018433318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PQ34"/>
    <dbReference type="FunCoup" id="A0A167PQ34">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167PQ34"/>
    <dbReference type="GeneID" id="28994224"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_154365"/>
    <dbReference type="InParanoid" id="A0A167PQ34"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000043">
        <property type="entry name" value="General stress response phosphoprotein phosphatase Psr1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="1">
        <location>
            <begin position="32"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="209" mass="23736" checksum="F1F1B2787FBA4D7A" modified="2016-07-06" version="1">MNPFPSPNKPTISRLHQNQNTSTWLLPPLTVADQTKKCLVLDLDETLVHSSFKVIPNPDFVVPVEIDNQFHNVYVLKRPGVDEFMRRMGEIYEIVVFTASLSKYADPVLDILDIHKVVTHRLFRESCFNHRGTYVKDLSQLGRDLESTMILDNSPASYIFHNANAVPVSTWFNDPHDTELTDLVAFLEDLTSVQDVTLVLDSTVEPISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q3D8</accession>
    <name>A0A167Q3D8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_100673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD79004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297044.1">
        <property type="nucleotide sequence ID" value="XM_018427601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q3D8"/>
    <dbReference type="STRING" id="763407.A0A167Q3D8"/>
    <dbReference type="GeneID" id="28988507"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_100673"/>
    <dbReference type="InParanoid" id="A0A167Q3D8"/>
    <dbReference type="OrthoDB" id="10044727at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD79004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="183" mass="21149" checksum="1566CBF3DBF9D706" modified="2016-07-06" version="1" fragment="single">EWGYVFRKNSKNIYYDGHEREDAIAYHQKWAKRMMVYKKKMATFSENEETIVLPVLRSNEIEHVLVTHNELTFYANDGKDTMWLMEVENPIRKKGPGMSLMISGFKCVCHRTMAGGAWLSQEVFRPGADIDGYWMSADMLKQLKNNVIPLFELIHPGCKAVFSFDQSTNHKAYGQNALISSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q6Z2</accession>
    <name>A0A167Q6Z2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Amine oxidase</fullName>
            <ecNumber evidence="15">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHYBLDRAFT_176627</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a primary methyl amine + O2 + H2O = an aldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16153"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:228804"/>
            <dbReference type="EC" id="1.4.3.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="15">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="14">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="14 15">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="15"/>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297219.1">
        <property type="nucleotide sequence ID" value="XM_018437805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q6Z2"/>
    <dbReference type="FunCoup" id="A0A167Q6Z2">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167Q6Z2"/>
    <dbReference type="GeneID" id="28998711"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176627"/>
    <dbReference type="InParanoid" id="A0A167Q6Z2"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049947">
        <property type="entry name" value="Cu_Am_Ox_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008559">
        <property type="entry name" value="PRK11504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF86">
        <property type="entry name" value="COPPER AMINE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01165">
        <property type="entry name" value="COPPER_AMINE_OXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 15" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="17">
        <location>
            <begin position="20"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="18">
        <location>
            <begin position="116"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="16">
        <location>
            <begin position="248"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="13">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="14">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAD79179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="683" mass="78085" checksum="5F7E804F2DD377EB" modified="2016-07-06" version="1">MSSLKEINPISTNTENSRFHPLDQLTGDEIMTVAEIVRKGVPNLNIVFNTITLKEPKKELMMSYLGWDTTKPRITKIEREALVVALEKPSMKCYEALVSLDNGQLKRFEHIPDVQPILTMDEMFEVEELVAKDPRVQAECRELGIEDMSCVFSDPWAIARHVTYKGRSKRMMQALMYMRTCEDDNQYAHPLDFVPIIDLGLMKVVDIERIKPRDSKFTRPTIPLEKHNFLPEFVGEENFRKDIKPIIVQQPEGVSFKVKGTEIDWQKWNMKISMNYREGLVIHNVSYQDGAEKRPLFYRISLSEMVVPYADPFTPHNRKHAFDVGEYGLGLCTNTLTLGCDCLGSIYYFDATFNDHNGKPFHVPNAICLHEEDAGILFKHTDYRNGRAHAVRSRRLVISQIVTVANYDYGLYYYFYQDGSFQYEVKATGELNTHVLAEDETPGPYGVMVAPQINAQYHQHFFTMRIDPMVDGANNSICKVDTQRVPHATGHPNNMYGNGFYSESTILKDTAEGQQTANYETARFWKIINENRIHPYSKGPVGWKIVSNHHTPLFAQDDSVVGQRAGFAKKALWVTPYNENQIFAGGFYCNQSDGDDNVEHWVKDVQSIQNKDIVLWYTFGVTHLPRVEDFPVMPVEMCGFSMKPCNFFMANPGIDVPPTNKGINHSKLASKEKENKAACCTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q710</accession>
    <name>A0A167Q710_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_58230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297226.1">
        <property type="nucleotide sequence ID" value="XM_018440282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q710"/>
    <dbReference type="STRING" id="763407.A0A167Q710"/>
    <dbReference type="GeneID" id="29001188"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_58230"/>
    <dbReference type="InParanoid" id="A0A167Q710"/>
    <dbReference type="OrthoDB" id="2363417at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007891432" description="Galactose oxidase" evidence="5">
        <location>
            <begin position="24"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="532"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD79186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="61149" checksum="D8E431D18FF954EB" modified="2016-07-06" version="1">MRTSLTSIIFLLLLNGLLRTAVAFRPKARYAGGCALLDGALYCYGGAMYIAGQGHPTSLAEHFSLDLRHSFGIPESLSKWKSLNNLTSFLLEPNSYFSIVPQPSSQSYVISGGIGYNNGSSLINPTTVYNASTDTWTSVNTTGIIQRFGQTGVLQLDSGILFWGGLGGYLTGLSNRGITTDTYSPKLLSPSVSIADCDFRNILSLIVIYLTINQCTKFDEWSTMSTSAFPLGAYARVYGSATMGRDGRSIFYIGGQTVQSAVVNTTSTIVGQGLGTVSMNDILIYDTVDASWLVKQAIGPTPSPRTLHTAVLGLTDRVDLIFIVPDTDMVLIYGGLGINSSFPVKDYVYQLDTVQLLWTQIPLPVTSGAGPRYGHSAVLYGNSSMFILFGVNEAGIPTDDFYVLELEDMKWTDYFKSDWTPHYQERNPNLVPVPLSGGDKHTTLGGVFISCGTIIGIVATAIVLLAARRKNAKEDSLYASLNAADERDERDIRRQGAIRISPRNSTYTLARSYRTSLPTDISRPIDSPGIYNYDETMQSQGSSATVYESIGTPPKGKSRQSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QR27</accession>
    <name>A0A167QR27_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_185062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298141.1">
        <property type="nucleotide sequence ID" value="XM_018439025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QR27"/>
    <dbReference type="STRING" id="763407.A0A167QR27"/>
    <dbReference type="GeneID" id="28999931"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_185062"/>
    <dbReference type="InParanoid" id="A0A167QR27"/>
    <dbReference type="OrthoDB" id="5398391at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="entry name" value="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37987">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37987:SF1">
        <property type="entry name" value="OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="UraD-Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD80101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="177" mass="19797" checksum="F433FDDEA1A36E48" modified="2016-07-06" version="1">MSLLPIEKINTASPKVFVEAVNTLFEVAPPLAQKLLSARPFESYSQLIDYAESLCLGSTFSEQEKLDIINAHPRIGENKTNLSAMSLKEQGYSPQSTLSAEDQQVNDTLAKLNKAYEDKYGFKFVVFVAGRPRSQIIPVVQERIAANDRSKELETGLTDMMLIARDRLKKSTNENKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QRN9</accession>
    <name>A0A167QRN9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_59189</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298187.1">
        <property type="nucleotide sequence ID" value="XM_018440450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QRN9"/>
    <dbReference type="STRING" id="763407.A0A167QRN9"/>
    <dbReference type="GeneID" id="29001356"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_59189"/>
    <dbReference type="InParanoid" id="A0A167QRN9"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="207"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="330"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="207"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD80147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="408" mass="45951" checksum="62A5201E8DD48D5F" modified="2016-07-06" version="1">MNCFLAYRLAKQKEVAAYCPGANHRDISKVIAKWWHNETQEEKKLYKRLAADAKHEHSLLYPDYKYKPRKKSANSAVKKSEIGRESSEELAMQSAYNTLKNSRNCNGGGSNGSGSGSGSCGPSTSANSINTMNHGLIDTGSYERIGYPPQNNISFGLYPNIEVPLIDSSQSNTWQAPFFPYQSSYLQANMNEPLGSQQQYILQTQAQAQNQNQNQNQNQNQNQNQNQNQTQNQSQSQYQSPILSQNQQHSQIRSHHQNQTLSSIKQNSQQHHYHQHHQQQQQSNSNSNTGYCQQVYQQQNALPSLFYGTSLPQIDPQSCFPLPSVPSPTDFSYLGHETPAQLSDTHQSPGSASSLSSVYQNGTNESMAFGSLLRENKEFDELSQPHWSGQTGWRLGFPVDEPLPYYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R551</accession>
    <name>A0A167R551_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_138421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298908.1">
        <property type="nucleotide sequence ID" value="XM_018429996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R551"/>
    <dbReference type="GeneID" id="28990902"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138421"/>
    <dbReference type="InParanoid" id="A0A167R551"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="247" mass="28419" checksum="82AE4EFA219D7F00" modified="2016-07-06" version="1">MEEDFIFDNDNEDNVNSDHSDDEEAFISAYQEESIFFSEDTNLKSLVINSNEIEEGNTSFDFEQGETLDVDTESSVTSRICEFSINSMPIYICFVTIFIVIFHLIFLVDNDRYILIEFCNNLLSICNLAGSLCLTINSLRHITGFDKATKGMTVYVTCSKCHLIYPPGTTIKNCNFKIFPESNTCNNPLYKFTIASHSSPVMMYPYNSLKHTLQQHFSKSDFEQRINLWRNHPTMENTKLDIYDSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167RCS9</accession>
    <name>A0A167RCS9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_3763</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299398.1">
        <property type="nucleotide sequence ID" value="XM_018440093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167RCS9"/>
    <dbReference type="STRING" id="763407.A0A167RCS9"/>
    <dbReference type="GeneID" id="29000999"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_3763"/>
    <dbReference type="InParanoid" id="A0A167RCS9"/>
    <dbReference type="OrthoDB" id="2271782at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF1008">
        <property type="entry name" value="KINESIN-LIKE PROTEIN SUBITO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD81358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="267" mass="30071" checksum="319CAC7E851E5D43" modified="2016-07-06" version="1" fragment="single">LISDLLHGENALVFAYGVTNSGKTYSIMGTPQDPGLLPRTLDVIFNSVKLDDKFEYGIWVSFAEIYTEKIYDLLVPPDRQLKRRALSLKYEFRSGHKYISGLKEVKVQSIEEAYVILREGQRNRAVFSTIMNQTSSRSHSVFTIRIVRDPSYVTVSKMSIVDLAGSERHRNTFNSGQRLKEAGNINKSLMVLGQCMETLRFNQLKAAMGKRQAVVPFRHSKLTELFKSSFEGDGKAVMVVNVNPFDTGFDENSHVMKFAAVAKDVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167RDJ7</accession>
    <name>A0A167RDJ7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_162028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299454.1">
        <property type="nucleotide sequence ID" value="XM_018434549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167RDJ7"/>
    <dbReference type="GeneID" id="28995455"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162028"/>
    <dbReference type="InParanoid" id="A0A167RDJ7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="165" mass="19916" checksum="90872ABB11C3320B" modified="2016-07-06" version="1">MLKRRYSYDDDDTTSEDLEYPDKLPMKGRAITRNGTRSEEDYNFIVDFKKEIKEISHHVLRHFISSIALTKYHTAMKLLEEIYSEQLDSSQPKILSTLDRFFPYLQTAKTFITRYNYWAFDSFHENIQHFNQTRKMWTAGTAFFRIFRRSVYRKQVSFGERDSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167RF71</accession>
    <name>A0A167RF71_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YbaK/aminoacyl-tRNA synthetase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_65726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299548.1">
        <property type="nucleotide sequence ID" value="XM_018441517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167RF71"/>
    <dbReference type="GeneID" id="29002423"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65726"/>
    <dbReference type="InParanoid" id="A0A167RF71"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007891892" description="YbaK/aminoacyl-tRNA synthetase-associated domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD81508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="12495" checksum="407A34A06E1A7840" modified="2016-07-06" version="1">MVGGLYLCLFPCFWINVTELLDQKKRVNEIYAKRRIALRAASNRFNGFPRVVPMTIGVLDYIKLREEHVEFIRDAFYGECQVTIGITKDKLLEQFLALKGVNLFISAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167RFY3</accession>
    <name>A0A167RFY3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_139104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299599.1">
        <property type="nucleotide sequence ID" value="XM_018430163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167RFY3"/>
    <dbReference type="STRING" id="763407.A0A167RFY3"/>
    <dbReference type="GeneID" id="28991069"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139104"/>
    <dbReference type="InParanoid" id="A0A167RFY3"/>
    <dbReference type="OrthoDB" id="2276331at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="148" mass="17012" checksum="E7C64747210068D5" modified="2016-07-06" version="1">MTKIQSASTSATTTTNTNINMTNIHQEAVNEVNEFLDTCYVLASEACWRIFSFKLHQEHPTHQRLAIHLENSQPVYFYDSTNRHQLSNANINTTLTDATSFQNLWTVEGQLYETNQAACQALGLLIDDKEWEKCMEEAKSYELPYSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N3U8</accession>
    <name>A0A162N3U8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type zinc finger transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_153256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441009">
        <property type="protein sequence ID" value="OAD65564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283604.1">
        <property type="nucleotide sequence ID" value="XM_018433100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N3U8"/>
    <dbReference type="GeneID" id="28994006"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153256"/>
    <dbReference type="InParanoid" id="A0A162N3U8"/>
    <dbReference type="OrthoDB" id="2382535at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="40042" checksum="8699DABA077548E7" modified="2016-07-06" version="1">MSTIPELYNEKCHCAGCSQNNLGYSFVARRTAQHHNKRARLNAIRCERDMSTQRNMIEVDNEAILTHQPRALEELYTQTNSPVWEGASMSDTEDVSVTNDAISNSDNDDSGRNSNEISEDESEDDVVELNNNELNSEDSFATPDMLQNPVHRFIATFVVMFASHYVVDKGAVVLIEFINKLLTIYKQDFQLPLSLPGLQRMTGFSAMTKGIKKFVVCQDCHKVYKESASVPSHCDFVKLGAHSSCNCQLTKTSALGALVAKRSYLYQSVVNALQMFFLHSGFEDKIRHWNHELKMVDTMCDIYNGAMWKELKDKDGVQFTKDSRSLMLTLNINWFQPFDNVTHSMGAIYTGKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N4V5</accession>
    <name>A0A162N4V5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_117121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286588.1">
        <property type="nucleotide sequence ID" value="XM_018428564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N4V5"/>
    <dbReference type="STRING" id="763407.A0A162N4V5"/>
    <dbReference type="GeneID" id="28989470"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_117121"/>
    <dbReference type="InParanoid" id="A0A162N4V5"/>
    <dbReference type="OrthoDB" id="3039677at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="185" mass="21072" checksum="A15E7399D39F2BB9" modified="2016-07-06" version="1" fragment="single">NLPREERFKPENVILVGLMPGSKEPKTEEINHYLKSIVDELLQLFTRITIPTFECPAGVNVHAALHMVACDIPAARKTSGFTAHNSTCACPRCVRQFTRLPSTNQVDFSGFDYSTWKIHSGLESRLHAEEWKSASTPSERHQLEIENGVRWSQLHRLGYLDLVCGTIIDPMHNLFLGTPKRMMEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N7W5</accession>
    <name>A0A162N7W5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_152169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441001">
        <property type="protein sequence ID" value="OAD66624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284664.1">
        <property type="nucleotide sequence ID" value="XM_018432860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N7W5"/>
    <dbReference type="GeneID" id="28993766"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152169"/>
    <dbReference type="InParanoid" id="A0A162N7W5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="53" mass="6113" checksum="F7C0318FB02C5C1D" modified="2016-07-06" version="1">MSRFTFKPSTDCSSSRCLYSTLFTVSSIPKTNDDNKLLLKRPANSWDVYKNTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N865</accession>
    <name>A0A162N865_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_169916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290048.1">
        <property type="nucleotide sequence ID" value="XM_018436209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N865"/>
    <dbReference type="STRING" id="763407.A0A162N865"/>
    <dbReference type="GeneID" id="28997115"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169916"/>
    <dbReference type="InParanoid" id="A0A162N865"/>
    <dbReference type="OrthoDB" id="10044727at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="44608" checksum="4AD9B2C8A3543640" modified="2016-07-06" version="1">MEYYQYSEKNDNVTPSLVSYSQLPEGVKQHVFVTHDKSTFYANDYQKYAWVEDGESYCLPKSESRSIMIFGFQCPCHGTMREYVRDQYKTLQVVFYPGAQYEGYWKSSHMCVQLTDIIPLFNAIHPNAVAVFLFDQGSHHKTYPEDALLAQNMNLCAIEVKDSDSGQGKFRDSSFYVRKQYDYAEHNEEKLKEYEVIESWLYKNKKYKKYFIGLCGILQQRSMYINEAERYSLKSSCNNVMTADSRCCAIYIMERQPDFANQKSALKEIVEGSGHKFELYPKYHCECNWIKRYWGAAKKEAQRECDYSFQSLNRKINSFLDSVCLPEDDVPEKIRRYFHKSFAYINAYSLGHDTEHAFEIVKQFSKLHKSHYKLRLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NAE7</accession>
    <name>A0A162NAE7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI ethanolamine phosphate transferase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_96729</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290638.1">
        <property type="nucleotide sequence ID" value="XM_018443982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NAE7"/>
    <dbReference type="FunCoup" id="A0A162NAE7">
        <property type="interactions" value="354"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NAE7"/>
    <dbReference type="GeneID" id="29004887"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_96729"/>
    <dbReference type="InParanoid" id="A0A162NAE7"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051267">
        <property type="term" value="F:CP2 mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16024">
        <property type="entry name" value="GPI_EPT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037674">
        <property type="entry name" value="PIG-G_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039527">
        <property type="entry name" value="PIGG/GPI7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045687">
        <property type="entry name" value="PIGG/GPI7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19316">
        <property type="entry name" value="PIGO_PIGG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="685"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="719"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 2 C-terminal" evidence="13">
        <location>
            <begin position="445"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 2 C-terminal" evidence="13">
        <location>
            <begin position="562"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD72598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="743" mass="83927" checksum="3E8975EBF85A562D" modified="2016-07-06" version="1" fragment="single">ILQIIGLGLFCKGFFPYKIQIAGHATYESTPSWPDDNSQSRPLVIEPEFDRLVFVVIDALRKYGFFFVFFLFNISVYIYMCVLIESKTAIPFTARATAPTVTLPRIKALTTGTIPSFLDAILNIAESDTSSSLEHQDNWVYQLKHHCNNTIHFFGDDTWIRLFPGLFTKQDGTTSFYVSDTVQVDLNVTRHIQTDMTVPDWNTMILHYLGLDHVGHLGGPKSPLMKPKQEEMDRALEQIYQLVAEQDSERIVKDANAKGTLIVVCGDHGMNEVGNHGGSSLEETSAALVFMSPRFESRPVLKKHSTRELPERPSAFGFPIIDQIDLVPTLASVLGFPIPKNNLGKVIVDLYRGDKDSSILRALQLNAYQLGQLLSKSIPEPSKNTEEYSVVFGDNSRNEQGYARAVALHKQALDDIKNEQATETALNAYLEFIEYAQSYLVDTSSDYGLGYMLTGLGLICISTILLVRLSLTPESENSCQEHKSWLHTKLFVMVSIVGYIASMFASSFVEEEHLIWYYCLQTIFVILALQRSNSWLPYFLCHNYHYCALLPHDRVGSFLHILLYTSTPILLLISRSQNAFLFSVYAVQFYLLEQWQRSSMPVPVPPWLLGAIVTLFSQAAFFCTGHSNSIASVDLSSSYIGVDGYDPLVIGLLTFCSNWAGSLWWKKRDADVDADAELRWWNYSVTLSAVSGSFLVALSLSVTLLREHLFIWTVFSPKYLYQVAWTCLFHWFVHMFVGSIVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NBP8</accession>
    <name>A0A162NBP8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_188963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285764.1">
        <property type="nucleotide sequence ID" value="XM_018439589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NBP8"/>
    <dbReference type="GeneID" id="29000495"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_188963"/>
    <dbReference type="InParanoid" id="A0A162NBP8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="113" mass="13497" checksum="2F205C3667C3EAFD" modified="2016-07-06" version="1">MSHLPGVLFFWKDLERPIDMILLQSDQSESFGKEEHLCYWEIRLTGIAEDIILSFSLTLRFSSNQYSFTTPSMELPYMIRGWFSMHDSDYISYDDIIIIWDTSVDYYKHNYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NGE1</accession>
    <name>A0A162NGE1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-lysine(4) N-trimethyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_20422</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="2"/>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292028.1">
        <property type="nucleotide sequence ID" value="XM_018439732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NGE1"/>
    <dbReference type="STRING" id="763407.A0A162NGE1"/>
    <dbReference type="GeneID" id="29000638"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_20422"/>
    <dbReference type="InParanoid" id="A0A162NGE1"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="11">
        <location>
            <begin position="20"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="12">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD73988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="169" mass="19469" checksum="8B0632C2311CF9AA" modified="2016-07-06" version="1" fragment="single">NKAAGESDTIKINHLKNRRKQLRFAKSPIHAWGLFAEEPIDANDIVIEYVGEVIRHQVAEKREKEYERTGIGSSYLFRVDNDRVIDATKRGNVARFINHCCAPNCVAKIVTIDKQKRIVIYSSRDIVPGEEITYDYKFPIEQEKIPCHCGSKFCKGRCVKLLNSREILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NL86</accession>
    <name>A0A162NL86_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CBF1-interacting co-repressor CIR N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_143516</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293298.1">
        <property type="nucleotide sequence ID" value="XM_018431001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NL86"/>
    <dbReference type="STRING" id="763407.A0A162NL86"/>
    <dbReference type="GeneID" id="28991907"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143516"/>
    <dbReference type="InParanoid" id="A0A162NL86"/>
    <dbReference type="OrthoDB" id="2159131at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039875">
        <property type="entry name" value="LENG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER LRC MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093:SF0">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="3">
        <location>
            <begin position="8"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD75258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="219" mass="25502" checksum="4F7049338E1BC79F" modified="2016-07-06" version="1">MNILPHKSWHVYNRENIEKVRKDEAKAKLEESSKQERVQLAESEARLNLLRQRAEKRLEESGISNNALSTTSQTLITEETPWYSEKKSDKYTDTHVRRYKPKDESSKRKRKPAITTEEDPMAIVKKHLDKREKVKNPYSYSKRPSKTKSKSTNASSTSTQSSSIEALRAQRLAREQAERVRTKAVVYGEVAAPKEHRYNAQFNPKETAQARDRRKPSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PKY6</accession>
    <name>A0A162PKY6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="3">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GTP cyclohydrolase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_112460</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="3"/>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291847.1">
        <property type="nucleotide sequence ID" value="XM_018428287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PKY6"/>
    <dbReference type="FunCoup" id="A0A162PKY6">
        <property type="interactions" value="380"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162PKY6"/>
    <dbReference type="GeneID" id="28989193"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_112460"/>
    <dbReference type="InParanoid" id="A0A162PKY6"/>
    <dbReference type="OrthoDB" id="4966at2759"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00642">
        <property type="entry name" value="GTP_cyclohydro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.286.10:FF:000003">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1130.10:FF:000012">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006825">
        <property type="entry name" value="PRK09347.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006826">
        <property type="entry name" value="PRK09347.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109:SF7">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="GTP CYCLOHYDROLASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase I" evidence="12">
        <location>
            <begin position="67"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD73807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="245" mass="27509" checksum="FA63FCAA4FE669CF" modified="2016-07-06" version="1">MSLENTGLLVEPKPLRPLRPIVQSTEANPSRQGTPVDMDGLSWPSKGARDRRDESEEAKAERVRKIAGAVETILTCIGEDSDREGLLKTPERYAKALMFFTKGYEENIKDVLNAAVFEEDHDEMVIVKDVDIFSLCEHHMVPFTGKISIGYIPNRRVVGLSKLARIAEMFSRRLQVQERLTKQVATALMEILQPQGVAVVVECSHLCMCMRGVQKPGSATTTSCMMGVFRSNPKTREEFLTLIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PS06</accession>
    <name>A0A162PS06_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_65588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290406.1">
        <property type="nucleotide sequence ID" value="XM_018441488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PS06"/>
    <dbReference type="GeneID" id="29002394"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65588"/>
    <dbReference type="InParanoid" id="A0A162PS06"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="165" mass="17991" checksum="DEF81026A0CFEB14" modified="2016-07-06" version="1">MYLQLCFIFVSYSYFKQNWFKQKRVDNCFSKIKEININGNHIFNKVNNSSSKPPCAHFLEGALVESIFLVPSKKVFNLLLDLLRTEATVAGTILANGGNGFATSSSLALVIARVVGARVITSTLGEAKGSGRGGRGKGQDGEEGGKDGLLEKHVDEDEDEISFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PXF2</accession>
    <name>A0A162PXF2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_111683</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293136.1">
        <property type="nucleotide sequence ID" value="XM_018428228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PXF2"/>
    <dbReference type="STRING" id="763407.A0A162PXF2"/>
    <dbReference type="GeneID" id="28989134"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_111683"/>
    <dbReference type="InParanoid" id="A0A162PXF2"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD75096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="413" mass="47005" checksum="32585EB11578A2C2" modified="2016-07-06" version="1" fragment="single">FSGYVDVLDTDDHFFFLFFESQGSPASDPTLLWLNGGPGCSSMAGAWVEIGPCLINGDANGTHINPHSWNKLANLIFLDQPVGTGYSYGKSRVTSSNRAAQDVYAFLQVFFRMFPKYKTQFHIAGESYGGHYIPTLADVISTNNEHAHENDLLPIELVSILIGNGWTGFSTQIGFYEDYGCSNDNQPIFDEQVCKSMRDTKARCQYLADLCYKYPSRATCYPAGLYCKHTQLDPFENTGLNPFDIRRVCGQTTDYCYQEMYRLEVWADKDYVRQELGVDPQVGQFSHCNPAMETRFVLSADMVYDFSHYISQSLTRGVRVLMFAGDMDWQCNWYGNKALSLGLEWPGKDEYQQAKDEVWRNSDTRKIAGYVRSFDKLTFIRILNAGHMAIFDQPENGFDLISKWISNLTLQDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q5J0</accession>
    <name>A0A162Q5J0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_137824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298316.1">
        <property type="nucleotide sequence ID" value="XM_018429880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q5J0"/>
    <dbReference type="GeneID" id="28990786"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_137824"/>
    <dbReference type="InParanoid" id="A0A162Q5J0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="332" mass="37091" checksum="8BBB9AC7601AE943" modified="2016-07-06" version="1">MTKRIPTAPRRPNLRMNAVLNSTIAGVIAPIDTPTPEVAVDTAPEVQVAVTPMDHVLTLLAANNVSMQSLQENAKGVTDAITHLKNGLDLSNKTNEFLKNSVLQLMTENAEIKKAMTSQNSVMPSAVPVDSSSSMDDDLDLGVKHHPLISQLINSYIKKPNFVSTDLLKVTENNNRSAWSMTGTYGDKYNKTLALALFKYLRPQRCCTNVSKSVIMNIIKNHYQNQLLDRCIITYQTYTEAIHEGMNRCDCGNILSIDVMSDGKSDGDNKVRAYRPSWRTDELQTFISTIDELTVIRLKKNSESLKKRIPYEKEVSIPKNLAVTLPDWCFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q6F1</accession>
    <name>A0A162Q6F1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHYBLDRAFT_129191</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. SEC13 is required for efficient mRNA export from the nucleus to the cytoplasm and for correct nuclear pore biogenesis and distribution.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298546.1">
        <property type="nucleotide sequence ID" value="XM_018429269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q6F1"/>
    <dbReference type="FunCoup" id="A0A162Q6F1">
        <property type="interactions" value="801"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162Q6F1"/>
    <dbReference type="GeneID" id="28990175"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_129191"/>
    <dbReference type="InParanoid" id="A0A162Q6F1"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000904">
        <property type="entry name" value="Probable SEC13-protein transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="13" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="6 18" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="18">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="18">
        <location>
            <begin position="210"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAD80506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="309" mass="34398" checksum="DCBF837896C8CD9D" modified="2016-07-06" version="1">MSQTATQTIETHHEDMIHDAQLDYYSRRLATASSDHTIKIFDVDGDSQRLVETLTGHEAPVWQVSWAHPKFGSILASCSYDGRVFIWKEQNGTWSRIKEHNVHTASVNSVSWAPHELGAMLACASSDGKVSVLEYKDDGSWETYVIDAHGIGCNAVTWAPAAIPGSLVQANGGAPTISVVKKLVSAGCDNLIKIWGWREDTKSWQEEETLEGHSDWVRDVSWAPSIGLPKSYLASCSQDKTVLIWTQNSPNSKWTKKLLGEKFPDVVWRVSWSLSGNVLAVSCGDNKVTLWKEDSKGEWECVQQLEEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q7E3</accession>
    <name>A0A162Q7E3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_156967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298776.1">
        <property type="nucleotide sequence ID" value="XM_018433539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q7E3"/>
    <dbReference type="GeneID" id="28994445"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_156967"/>
    <dbReference type="InParanoid" id="A0A162Q7E3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="55" mass="6129" checksum="6DBFAE85A3BDEF0B" modified="2016-07-06" version="1">MAAYINIWLPDLRSPPVNGQLSLKQCEVSECLVCGTFLRCDHVRFISNCSIRSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TI45</accession>
    <name>A0A162TI45_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CCHC-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_118509</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285383.1">
        <property type="nucleotide sequence ID" value="XM_018428639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TI45"/>
    <dbReference type="STRING" id="763407.A0A162TI45"/>
    <dbReference type="GeneID" id="28989545"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_118509"/>
    <dbReference type="InParanoid" id="A0A162TI45"/>
    <dbReference type="OrthoDB" id="444325at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061632">
        <property type="term" value="F:RNA lariat debranching enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF4">
        <property type="entry name" value="CWF19-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD67343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="290" mass="32863" checksum="CD292CD52DE8F406" modified="2016-07-06" version="1" fragment="single">PPKNYICNRCKVPGHFIKDCPERANEESAVPPENYVCRICNIPGHFLNKCPQKDTHDKKSNGRHVIVPDSLDACWFCLANPKLAKHLIASIGTQVYATLAKGPLVMPGMPEATVPGGGHILLIPITHYPTLNKIPGESRTEVIDEMEKYKMALKSMYDKYNQDMVVIEMSRESISGLSHAHVQVVAVPKNKSENLENLIKNEFELRNMAFVDQNDPEVSYFKIDIPNGKSFVYIIPTRLKFNMQFGRLLLAKALGHPEREDWKACSQTIDEERNATEDFKKAFKSFDFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TNQ1</accession>
    <name>A0A162TNQ1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="5">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_178171</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="5"/>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286633.1">
        <property type="nucleotide sequence ID" value="XM_018437962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TNQ1"/>
    <dbReference type="FunCoup" id="A0A162TNQ1">
        <property type="interactions" value="80"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TNQ1"/>
    <dbReference type="GeneID" id="28998868"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_178171"/>
    <dbReference type="InParanoid" id="A0A162TNQ1"/>
    <dbReference type="OrthoDB" id="44061at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.20:FF:000009">
        <property type="entry name" value="Peptide-methionine (R)-S-oxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00357">
        <property type="entry name" value="peptide-methionine (R)-S-oxide reductase MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081:SF8">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="6">
        <location>
            <begin position="8"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD68593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="134" mass="15179" checksum="454B5AF9C4F54EF5" modified="2016-07-06" version="1">MTTQRKSELEWKTILSPEQFRVLRQKGTEPPGTGEYNKFNKKGIYNCAACNAPLYVSDTKFNSNCGWPAFFDAIPGAIIRHEDNSAGMRRIEICCAKCDGHLGHVFQGEGFPTPTDERHCVNSISLRFNDEEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TTU7</accession>
    <name>A0A162TTU7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_171014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288982.1">
        <property type="nucleotide sequence ID" value="XM_018436472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TTU7"/>
    <dbReference type="STRING" id="763407.A0A162TTU7"/>
    <dbReference type="GeneID" id="28997378"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171014"/>
    <dbReference type="InParanoid" id="A0A162TTU7"/>
    <dbReference type="OrthoDB" id="2289822at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="52407" checksum="BAFF90E4923E845B" modified="2016-07-06" version="1">MCFLESEGPTPMRDVGSIHKAKGSRPGGGRYNAFVELPTLTSSAFFGQDEMHLLGHGTGHQLYQALGGKFCPGTAGLGRKSHGMHLQERLQRLEYPFALDVSLDDIEKAVSTSRADIPMAFTGTWRSMKESNGKRKTINWMDFLLFIVPTMVINHLCFADAKQAVRDLVLACFIVQQWSITTSDIVAVEAIGHWHSFLRCKISDGKLKSNIFVMNQHMLVHLGFMLWEMGPLQAYSCRPIEYTIGTYTSAIKSRKEPGKNMENVLFQMAAISHCRGNCPARTGPADRRTSNFKVASDDIAGPQLWSSLTRYSMAELANTIGMEWKDLVQQLLPFWAGEGVSSFEEQDSVVCTTKMWKDSVVYRVQSSFDSRHVQANNLVVLKHMWDYGFVRKFFSHIVKGVTRLFAATESLSDVRPLPGMLFPVSSNCSQGEMRIVDVKSFKGMAGLVHDTKDGAIRHIVWPLPTHNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TW46</accession>
    <name>A0A162TW46_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_170131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289492.1">
        <property type="nucleotide sequence ID" value="XM_018436257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TW46"/>
    <dbReference type="GeneID" id="28997163"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170131"/>
    <dbReference type="InParanoid" id="A0A162TW46"/>
    <dbReference type="OrthoDB" id="2287075at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="513" mass="59354" checksum="F75AC054CF832952" modified="2016-07-06" version="1">MNEATPFRVLTVKASIKATGWNPELLRPLQVLVAKLHTIVTHTFALSKHIFLAELALDPFFDLNGQINQPFFVEVFLSLIDRNTDSSRITEITRLNCELISRHINTYIHNISYARISLLNAHQIAMYEATKIHTTYIVNIKLRFGQHLCRVINILLDIKNRQRELTQQLRSQRATEERIKRMLTEHIFEPARIFKEGVSTHRLEDVFIDFRDQQNGVIKFRGTIQTDGVGISIIKQNKDTPKGPNPRRATTINPENFPYIHDLPPEQHKRIRGRCVLINHGRRDLLYCMRSLRIRLKRTKFRRILQDTKAQTPNVIAVEHEISQTSGRSNNITDFAFHTSIKAANSSIISSFYTNTVSCISQKPLFCKLRLSSYINRRKANERLVKYIRAKFGQDCVLVMGNWSAPHNRYHEPIKVLFRCTNLNCLENMDGSEVMHRLCNWDVAAVLNFRHILNNLRYDGTISVRFICVIQITPESRPTPIVFFSKVSWEYLVGTTVGSSSSSSSYFYFGVYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U1X5</accession>
    <name>A0A162U1X5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_134658</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289703.1">
        <property type="nucleotide sequence ID" value="XM_018429662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U1X5"/>
    <dbReference type="FunCoup" id="A0A162U1X5">
        <property type="interactions" value="528"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162U1X5"/>
    <dbReference type="GeneID" id="28990568"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_134658"/>
    <dbReference type="InParanoid" id="A0A162U1X5"/>
    <dbReference type="OrthoDB" id="1294322at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002190">
        <property type="entry name" value="Ribosomal_L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="5">
        <location>
            <begin position="11"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD71663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="182" mass="21730" checksum="38AE3D961A1B08E9" modified="2016-07-06" version="1">MVCRKRRNEKLNEYQVIGRKLPSDKEVSPKLYRMRIFAPNTVVAKSRFWYFLKKLRKVKKAAGEIVSINQISEKRPEQIKNFGIWLRYDSRSGTHNMYKEYREMSRCEAVATCYQDMAARHRARFRSVQIIRVAEVKNADVRRQYIKQLLTPKLAFPLPHRVQRAEKGNRSLYLAKRPSTFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U2Y1</accession>
    <name>A0A162U2Y1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_169846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD71933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289973.1">
        <property type="nucleotide sequence ID" value="XM_018436175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U2Y1"/>
    <dbReference type="STRING" id="763407.A0A162U2Y1"/>
    <dbReference type="GeneID" id="28997081"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169846"/>
    <dbReference type="InParanoid" id="A0A162U2Y1"/>
    <dbReference type="OrthoDB" id="2289822at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="412" mass="47141" checksum="49CBD4AD11DBA97E" modified="2016-07-06" version="1">MYFDDISVQLRPLEDFKVDNPPSIYTQLSTFSGSSFFALDELHLIARGIGKLVYDLITVTLTKETKIYYTHPDNTLNTTEYPFHIPRADLVTIGNCITSSQKYIPPSIQGSFDDVFAKIDNTRAVDWLDFLLYLVPTLVVPYLPNRAVKTALLSLTLTSELLDEMESYFKHWHSFLYKKVQNNTLSRSVFRPVQHYLVHIPYIIKQQGPLRCYSTHSMERVIGIFSKLIKSKSKGGRNASFLVEQFAIHNYTSMAISICDEVNLIRPKPYGRESYMDLPNDPSDAQLWEPFHQFVNLNDDLVEGVGGPSVKEALLIYYRRTTGLTSHEFGDSVVVVAARLWMNSTVYSPCMYQRKKNKTSCGNHYVMFTCPYRKEIQAYYCEYSAFYCGVLPISTGTKADLVTCAQTCYLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U5M3</accession>
    <name>A0A162U5M3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-hydroxyisobutyryl-CoA hydrolase, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_181301</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291672.1">
        <property type="nucleotide sequence ID" value="XM_018438449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U5M3"/>
    <dbReference type="STRING" id="763407.A0A162U5M3"/>
    <dbReference type="GeneID" id="28999355"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_181301"/>
    <dbReference type="InParanoid" id="A0A162U5M3"/>
    <dbReference type="OrthoDB" id="9936937at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058841">
        <property type="entry name" value="HTH_76"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25871">
        <property type="entry name" value="HTH_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEX14-like helix-turn-helix" evidence="3">
        <location>
            <begin position="75"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="2">
        <location>
            <begin position="287"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD73632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="611" mass="68518" checksum="37C0C254D3FF8AE2" modified="2016-07-06" version="1">MNSTEPQNLIDQSDIGKINSNTSNDVLQASELLKVKHSYYSRSKQPFGLEEFLAYEKQQQGPPVLESSKDNQKMAYERMDSYDYENDIKYQQSLPASVQAWINQRKDHSDWNKEVIEQEFLKAKAMYYILHVEPVDVAGYLAWKEKNEAKSQSACPFANLWKNKGKGKYRFAPQEQTSCASFITAETPDLIGGPAIINLSSPKSKNILTVGRLNELKKAYQDAIKNPKATSIFFTATVAENPTHEILSESTPLRAKDTKVVSCGLAYEETYNLVTASRSSCDLQASQNSLETAYHGISREIHQKGKPMVWFINGKVPHSAVYLYLSDMFVRVITEHTLLDIGVKPGHAPFSSLGFFQSRLSKAPRPLPSGIGLYLALSPPELGLLRAPELLRLGMADVFVPELRLQGTIESAKSMAVCPLPDTMKALQITLLSQHVYSGPDRLGVWEREIGDIFGAAKSFDELESSLQKINNKWSKSILEHWKQLPPILPRVMFRLVDKIKDMNSLDIYRIERTVNTQWRHSKDYQKWLKQESSWEEADEKHIASYFSDVQVPNGESMFYEAPKEEVEIPAVCPMSGIKSAAVCPVTGKKGTSDGNGGDEASGCPMSGIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U7F7</accession>
    <name>A0A162U7F7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">6-phosphofructo-2-kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_177667</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291023.1">
        <property type="nucleotide sequence ID" value="XM_018437913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U7F7"/>
    <dbReference type="STRING" id="763407.A0A162U7F7"/>
    <dbReference type="GeneID" id="28998819"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_177667"/>
    <dbReference type="InParanoid" id="A0A162U7F7"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000644">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF39">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE YLR345W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD72983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="428" mass="48715" checksum="576BF6B2D0B6DE54" modified="2016-07-06" version="1">MAAQLYKTASGRLFHAGAVAIITVGLPARGKTHLSRSLCRYMRWLGVSTKVFSVGNYRRERMGPVPNDYFDPTNHEAFEQRLHIADECLDDMIEWLKTGGGQVSIYDGNNVTEDRRRAIHDKLVANDIHPLFIESICNKPEIVLANIRSVKISSPDYVGWDPESAVVDYKNRIEQHMANYETIADLTLPFVKLMNVGEQLIVNNVHGYLQSRVVYFLMNLHNRRRTIYFARAGGSVSPSSFKDDAELSPEGVEYAQKLEEFVVSYREQKQTGSGSTEDQERQLVVWTSARKKGRQTAIPFVNAGIPVRQHSVLNQMNPGEVDGLTPEQIREKFPEEVISARANPYSHRYPRAESYHDLAIRLESVIMELEREKNDVLIIAHDTVLRCLYAYLFDRPESEIPTISIPRSCLIEITPTAYGCRESRIDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U7L6</accession>
    <name>A0A162U7L6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_144550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292132.1">
        <property type="nucleotide sequence ID" value="XM_018431238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U7L6"/>
    <dbReference type="STRING" id="763407.A0A162U7L6"/>
    <dbReference type="GeneID" id="28992144"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144550"/>
    <dbReference type="InParanoid" id="A0A162U7L6"/>
    <dbReference type="OrthoDB" id="2288122at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="165" mass="19149" checksum="D58B8E6DA7EDDB1B" modified="2016-07-06" version="1">MSTFNIAANYNNRIIPDYIEAPLENPLKVKTVVYLCDHAGKTQVKETSQPAQKHIRTTKSIKIDCSASIYKHTMTDGTVCIKYSWQHPNHDPFKIEEISLSRLSNELKQWVEGLVSQNMDWKSIKNMFRMSENRLLEAATFHTNNLIESYHNQLKTFYLGRARSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UCZ2</accession>
    <name>A0A162UCZ2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_133214</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292233.1">
        <property type="nucleotide sequence ID" value="XM_018429554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UCZ2"/>
    <dbReference type="STRING" id="763407.A0A162UCZ2"/>
    <dbReference type="GeneID" id="28990460"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_133214"/>
    <dbReference type="InParanoid" id="A0A162UCZ2"/>
    <dbReference type="OrthoDB" id="406864at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055235">
        <property type="entry name" value="ASD1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051563">
        <property type="entry name" value="Glycosyl_Hydrolase_51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776:SF0">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22848">
        <property type="entry name" value="ASD1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007840086" description="non-reducing end alpha-L-arabinofuranosidase" evidence="8">
        <location>
            <begin position="30"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase C-terminal" evidence="9">
        <location>
            <begin position="452"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD74193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="644" mass="69879" checksum="E4408D02129C370B" modified="2016-07-06" version="1">MKISSTSLSLSAVAALLCISSTFVNTASALSLTIRNDVAGNSSSPILYGFMYEDINYSGDSGLYGQMLRNWNFQAGDTGGAADLSHWSLVKQNTGSATITLDTANPLNSINKNSLRLDVTTSSASSRVGFSNEGWWGLRVQPGESYTATFFAKATSGFTGPLTVSIESNSGTVLASASVSGLTGAYQKFTVTLKPSVTTTTITNKFVVSVASSGAVGKSVWFDVFSLFGKTYKDRENGIRSDIGNVLEAVQPSFFRFPGGNNLEGQSIPQRWQWNETVGPLEERKGRFGDWSYWNTNGQGLLDYVYMCEDMNMVPVLGVYAGYSLDTSSVPEANLGPYIQQVLDELEYLMGSTSTTYGSLRAKHGHPEPIDIPYIEIGNEDFFSTTYDYRYKAFYDAIKKVYPDKKFISTGPQTSRPYDLLDDHFYLTSKEMIALFNHYDNYARGGSDIFVGEFGTNSQGCCGASAANLDAALADAVFMTGLERNSDLVKMIAYAPLLNRDGQTQWNPDLVGFNTEIVWGTPSYYIQLLWSANRADTILQVDASNGGFGPLYWVVGSKESTKQIFVKMVNTGSSSQTIGINLKGASVHSQGVARVVSGGLEDTNSASSPNTVGIKESVFSLTSATGFNYTFAPYSATVLLLHRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UD33</accession>
    <name>A0A162UD33_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dilute domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_143607</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293392.1">
        <property type="nucleotide sequence ID" value="XM_018431027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UD33"/>
    <dbReference type="STRING" id="763407.A0A162UD33"/>
    <dbReference type="GeneID" id="28991933"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143607"/>
    <dbReference type="InParanoid" id="A0A162UD33"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15473">
        <property type="entry name" value="Myo5p-like_CBD_DIL_ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037986">
        <property type="entry name" value="Myo5p-like_CBD_DIL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="195"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="3">
        <location>
            <begin position="425"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="715"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="766"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="799"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD75352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="870" mass="98102" checksum="B3F5DFAD85B9589B" modified="2016-07-06" version="1">MMGSTSIALPLDTDPALDLMHQKPKSPISDSANILSIIKEQANEDEDPEKNRVAYENMSCDEMAKRMADSYRQLSEMLGTTIATPSTVSEKSDTRDYDFPELTDEETEEGILSDPAEEAAKKLKMTKLFTKAASNGNADKVRKLLQDDKTKALIDIDAKDEDGTTPLIYAVCFGKAEIAQLLLAAGAKIDIQDAFGWSALMWATNNNHEGLVKILLEHGASSQTKSAKGRTVFDFLNTENQKIVEILTTNPRDSISSTSSIAGRTPGSVSSTSSNAGDCDFYYQSTVEGYDTFMEEEANRHQKLIETAMTLVGGNDVDKYKNNKGYHDFENDEDDDDDDDEDFEFNEDDDENYEDNEFHWDRCMPDQMFVFAADDLDYILDTVITNFQLPVKTKQEICVPANVAFLSARFAHYFSSDELLHQVLKGALDRMSKAVKANSRNVHVLAFWITNFTQALYYLKKDCGLVVATAEHQLRLSELVLETYLMIINDTERRLAKVIVPAMLEHEQIPGMEDVDFADDWQRFFRRTSRRSVGVPPDGGLAVQMKRNTTPDEAGHNISPQSITSLLDSILFVFDSYNVHPTIIIQALAQFFHYMSCEMFNRILTTKKLLCRSKAMQIRLNLSQLEDWIRAKQLPSSLASYLNPTIQLLQLLQCLTQLGDLPNFISTVQTFDVVNSLQIKRCLINYRYEVNEARLPEDVERYAIQVAEDSIRYKQARRQSRQSMDANRKSGIPLSRAQSVSLQRKPSRRDSVSSFVGSLMSSVGISSSISLPPTPTTTEYNIPLSAKTPADSNSKEKEKEEEEEEGEEEDTKEIKDSRFMLPFSVPTTAHMVAVHSWASEPEEARRDKELQAVPVIPEEWMDKLDKGSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UV38</accession>
    <name>A0A162UV38_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_130601</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296293.1">
        <property type="nucleotide sequence ID" value="XM_018429377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UV38"/>
    <dbReference type="STRING" id="763407.A0A162UV38"/>
    <dbReference type="GeneID" id="28990283"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_130601"/>
    <dbReference type="InParanoid" id="A0A162UV38"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000008">
        <property type="entry name" value="2,3-dihydroxybenzoate-AMP ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859">
        <property type="entry name" value="ACYL-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859:SF4">
        <property type="entry name" value="BUTANOATE--COA LIGASE AAE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="65"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="485"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD78253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="579" mass="64795" checksum="7931A9239DCB52A1" modified="2016-07-06" version="1">MSNSTSTESSTAVAKRRLEAISNQVSPLGSSTFDTASYNEQLRIHRKPNQAVHSTALTPLRFLLRSAMVHGTKTAIIHRSRSYNYQTFADRIRRLASVLINDYNVQKGDRVGVLCNNIPAALEGNYAIPFSGAILVPLNTRLATKELDYILDHSGVSVLIVQEELFEKLSEEAKAKIKLILVSDSEDFRSDPFEQLLERCTNPFSWNQLHLPEDENSVISINYTSGSTGRPKGVMVTHKGSYLHALTVAIQNRLTTESIYMWTLPLFHCNGWGYPWSVVMVGGTQVMLNKLDYEYIWKLLIETGVTHYAGAPTVQNEICNHRNARRLPQEVRVVSGGSALSSTLVKRMTALNLQPLQVYGLTEVYGPSVMSYDISALENIPEEERNSRLARQGFNTVVTDELRILNHDTIQDVAPNGKEIGEICITGNTTMIGYYRDPVETEKAFKHGVFWTGDLAVRHVDGSIEIVDRSKDVIVSGGENVSSIEVESAIVQMEEVSECAIVASPDPKWGERPFAFVILRENAKLDPKDVISHCKNVLAGYKCPEGVRFVNSLPRTSTGKVQKYILRDELWKNYEKRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UYN3</accession>
    <name>A0A162UYN3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_140896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296883.1">
        <property type="nucleotide sequence ID" value="XM_018430477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UYN3"/>
    <dbReference type="GeneID" id="28991383"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_140896"/>
    <dbReference type="InParanoid" id="A0A162UYN3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="163" mass="18196" checksum="766B45B9D5391C1B" modified="2016-07-06" version="1">MLETAYAWLEVRFETRFEGGEAATEQPVQGNPPDVNRLQPVVGGNTIPRPSPQGQPNSWVLSAGSVTAALVLHFIRGNTKEAQLLYSAIGRLARQLVQVIMSRYRTNGIAIPSWGSLAPNQRNILVRNLEERAARRNIALDRFENSWVSIFVLSQRWRTAVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V2F4</accession>
    <name>A0A162V2F4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_75537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297553.1">
        <property type="nucleotide sequence ID" value="XM_018443068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V2F4"/>
    <dbReference type="GeneID" id="29003974"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_75537"/>
    <dbReference type="InParanoid" id="A0A162V2F4"/>
    <dbReference type="OrthoDB" id="2402731at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD79513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="167" mass="19263" checksum="CFA32857E82257EE" modified="2016-07-06" version="1">MNYISPLRRTHSRRQNRFNHTSLTTSDRSFVEFIRCLSKAKGLVHDLQLFNQLVCPVLGSATLPTTLGSSSIPFQIEPSSRRHLIQHINSYLNSTFTRFSHLCKALLIILTKIEANHPVRKERIDSFRQDVHDQWQTATKIRTSLLLYIQPFRSLPLPISYSTSSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V5K7</accession>
    <name>A0A162V5K7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamine synthetase</fullName>
            <ecNumber evidence="3 11">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_106758</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3 11"/>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298202.1">
        <property type="nucleotide sequence ID" value="XM_018427959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V5K7"/>
    <dbReference type="FunCoup" id="A0A162V5K7">
        <property type="interactions" value="625"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162V5K7"/>
    <dbReference type="GeneID" id="28988865"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_106758"/>
    <dbReference type="InParanoid" id="A0A162V5K7"/>
    <dbReference type="OrthoDB" id="1936100at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="12">
        <location>
            <begin position="22"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="13">
        <location>
            <begin position="108"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD80162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="356" mass="39852" checksum="EA71B63241B7E17A" modified="2016-07-06" version="1">MSVISNNDILKKYLQLDQKGQVQVEYVWIDGFNQLRSKTKTVDKVPLSAACLSEWNYDGSSTGQSSGRDSDILIRPVALFSDPFRGGDNKFVICDTYNPDGTPHETNYRSSCEKIMLEHADKKPWFGIEQEYMLFDPETNKPYGWPKHGLPEPQGKYYCGVGSGKIFGRDIIEAHYRACLFAGVNISGVNAEVAPGQFEFQVGPCEGISMGDHLWAARYLLDRVAEDFGIIVSIHPKPVKGEWNGAGCHTNFSSLEMREEGGLVAIQDAIKKLGLRHSEHIAVYGQDNDQRLTGRHETGRIDQFSAGVANRGVSIRIPRHVEKEGKGYFEDRRPASNIDPYRVTDIVMRSIYATNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162W8B1</accession>
    <name>A0A162W8B1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_176225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441029">
        <property type="protein sequence ID" value="OAD65305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283345.1">
        <property type="nucleotide sequence ID" value="XM_018437694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162W8B1"/>
    <dbReference type="GeneID" id="28998600"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176225"/>
    <dbReference type="InParanoid" id="A0A162W8B1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="334" mass="38401" checksum="95ADAB0E2898CAB4" modified="2016-07-06" version="1">MSRNLNNNSVNNAFGEEPSVGSPPRNTNDIRTIMLQHSQGTVSNQRPLAPKRARLNLEGDSSGRTRNIHDVYEKLDTMNGVLNTVLKNTSSEKAEATASNAVEQDMSPGRQPTLDQLLRDYLSEEKLYDQYNTNENKNSEGNRLVLKSVTNYLRRQEEGKKVDLPTLRTKIVRHIGNRKLQEKKTGEKKQEENRRACLCQRRVKSCERRQSALKANRAHFVNSFGENVDSILHADYMSDLESDYEREEEEQDSSSERVFFGDSAQAGEAKRYSTKNYFFGWCGDRFVDELDADYEAAHDKKNNIRPFEHKFKGIRDKQLSKTKANKLPSWSKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WAP3</accession>
    <name>A0A162WAP3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_73281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441007">
        <property type="protein sequence ID" value="OAD65945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283985.1">
        <property type="nucleotide sequence ID" value="XM_018442817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WAP3"/>
    <dbReference type="GeneID" id="29003723"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73281"/>
    <dbReference type="InParanoid" id="A0A162WAP3"/>
    <dbReference type="OrthoDB" id="3247418at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="331" mass="37777" checksum="022F4D524AA68757" modified="2016-07-06" version="1">MHLHLHLHKCIRDFGPVNMFLDVINPTTKCLDHHRLFGFERYNGILKNFKTNGKDGFEATYMKNFVQNAYKGDYVNAVLKSSSQIPFIHTLSKLVTTSIPAATVTTLSSRPFRLQVFVQGYTDPYNPPKGNEPLPPSTFPLKYKKPSVMDDSNHLHLLEYYQVAYNLPDLASYQDTSYNRPALDNQIIKLKSIDILGQHYRGTNNSTISHGSLVQTKFVGSNGNIILGFAGQIQYLFTYSFQLPPTHNLHLTRMVHDHQHVFTFIKWFRTSSDRSREDDGVEFCLPTFSPDSYHSIIPVHRILLEVATATIATSRNVSKMLVIPLPKKLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WLK4</accession>
    <name>A0A162WLK4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_172725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286915.1">
        <property type="nucleotide sequence ID" value="XM_018436863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WLK4"/>
    <dbReference type="GeneID" id="28997769"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172725"/>
    <dbReference type="InParanoid" id="A0A162WLK4"/>
    <dbReference type="OrthoDB" id="5596236at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="105" mass="12732" checksum="CD85A8F532E1D792" modified="2016-07-06" version="1">MADIITPRQLFSKYYDIDEETSPFGCTNLNCLENMDRSEVMHRLWNRDLAAVLNFRHILNNLRYNGTIPVRFTRVIRIGRIRRQAEEDLQEGRRLRQRLTRIQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WPE2</accession>
    <name>A0A162WPE2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_149221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287475.1">
        <property type="nucleotide sequence ID" value="XM_018432237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WPE2"/>
    <dbReference type="GeneID" id="28993143"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149221"/>
    <dbReference type="InParanoid" id="A0A162WPE2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="213"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD69435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="270" mass="30972" checksum="1A105A492C60D0C2" modified="2016-07-06" version="1">MSSIEQLLHFLLKDGGKNLEKYLGRIINGRTFKATKSGVINQFWDQSSKESHGFDDSVSGKAEFNKRLNTICPEFFEMKIIMKTRKTASPCVSNSNIPLVFSDNDDDDDLDSAQEDESNGGKDAGEGEGGSEDEDCDKMKRVNGIIIRDSVLLVSEADLPSSLRAANESKEERAEKKLKIISGCAKWFQDAKVSLLELQYERDREDKLKIIADKREERGKKNDEERLERLKKNKEDQVVKMLEIKARLFRWSEEKFDKKYTKYLIKQILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WX56</accession>
    <name>A0A162WX56_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_182223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289385.1">
        <property type="nucleotide sequence ID" value="XM_018438592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WX56"/>
    <dbReference type="STRING" id="763407.A0A162WX56"/>
    <dbReference type="GeneID" id="28999498"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_182223"/>
    <dbReference type="InParanoid" id="A0A162WX56"/>
    <dbReference type="OrthoDB" id="10256309at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="94"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="313" mass="36772" checksum="DCDE6E2250E991A4" modified="2016-07-06" version="1">MTTIKPAQLSALEDLTHAVAGLVHVEEPCLKTIETIRHLEMEKKPLQKNLEEKTTKLTYWKKEEININSWSIQWFFLSITCEVKAELERVRKHMKKDEELVREATSLVEEVDERIRDVERQNEKNEVDYRSLKNHREDLTELLDELLKGQDFGTEASLRKEIDDLEKEIEEAIESYNNLDRVRVCLTTADTALLEAILDLRQSNKEKEIGEGNVYFPQIAYDAIKEARELCKSLPPIQAPDKLEENDENTKAFYSPVQRYLWSVRRQLELLLEWCDKHSLDLVAVQTAKRLASGEKIDEWNRERRRLVKQVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XEH5</accession>
    <name>A0A162XEH5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_144803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292395.1">
        <property type="nucleotide sequence ID" value="XM_018431294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XEH5"/>
    <dbReference type="GeneID" id="28992200"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144803"/>
    <dbReference type="InParanoid" id="A0A162XEH5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="253" mass="29220" checksum="DF49C840C349E4BE" modified="2016-07-06" version="1">MSDINTTLINSVRKIEIDIVKIKQMVRMLQDQFSKQFVPAVSAKDLSIMQQSIIEQTLECVAKSVKRSQFTEYPDQLGKRVIGTGGDFKGKNKAQKYNLLLQLLHEQEWKDHYNDLSMKQLQLKMLSCTIKHNLIDIDFPALSKEWKGILAKHQEYYMMQLERMAKDNDFAIYKCKSMWCVKSLLRGSFKSDNQKQKRRMVKKNIAQQDANDSLLSSDNMSETDSDESSIMANVLSPLAEMSVEPAHKRSQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XQT5</accession>
    <name>A0A162XQT5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_76016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294245.1">
        <property type="nucleotide sequence ID" value="XM_018443112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XQT5"/>
    <dbReference type="STRING" id="763407.A0A162XQT5"/>
    <dbReference type="GeneID" id="29004018"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_76016"/>
    <dbReference type="InParanoid" id="A0A162XQT5"/>
    <dbReference type="OrthoDB" id="5407799at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19817">
        <property type="entry name" value="Bbox1_ANCHR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044553">
        <property type="entry name" value="Bbox1_ANCHR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603">
        <property type="entry name" value="ABSCISSION/NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603:SF1">
        <property type="entry name" value="ABSCISSION_NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="260" mass="29032" checksum="F93A5F9F5BC90B4E" modified="2016-07-06" version="1">MSQGNDDDFTNRIAKLVGSNDTKPLPSDAELANRFSKVFSSQPVAKQAKFDYHIPNNLANDDEDVEKLLSELDLLNDSDNDGLLDDDLLASLTSPEDQKAQKEKLNQLEAAFLGTHSAETGLEDESHTLIRRIQEESALDEKYATFAKKRDEDLKKRYEALQQGCNFSPANSGEVSSASNFKKQENSGKPRGSVPAALTMDEIYNETDDWCCMCNDDASLICKGCDNDKYCKSCFYEGHRGEMADYEATLHVAKEWSKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XVY8</accession>
    <name>A0A162XVY8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_74636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294805.1">
        <property type="nucleotide sequence ID" value="XM_018443030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XVY8"/>
    <dbReference type="STRING" id="763407.A0A162XVY8"/>
    <dbReference type="GeneID" id="29003936"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_74636"/>
    <dbReference type="InParanoid" id="A0A162XVY8"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF1">
        <property type="entry name" value="CAMP INDEPENDENT REGULATORY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="202" mass="22547" checksum="C1310287236F1447" modified="2016-07-06" version="1">MESFIGYIKSPQDALIVFEACRRGQLNRVQRRLSSKERVHISSGSVFAWDEREAGMRRWTDGRTWSPSRVLGSFLTYRELDTKRRPRLSSSSSTSSLPITSKASAACSYKTDGLIKQSFSICTATNQKLHLISYYSKSDIIASRLKRPSADPLLSKIVIPKGLYPELNPLDTSGGHSATNILSYQSKTLPGKDCHVLKTDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y3X1</accession>
    <name>A0A162Y3X1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-4-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.68</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-phosphatidylinositol 4-phosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphosphoinositide kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PIP5K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_97688</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14425"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.68"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.1.68" evidence="2"/>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296245.1">
        <property type="nucleotide sequence ID" value="XM_018444028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y3X1"/>
    <dbReference type="FunCoup" id="A0A162Y3X1">
        <property type="interactions" value="423"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162Y3X1"/>
    <dbReference type="GeneID" id="29004933"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_97688"/>
    <dbReference type="InParanoid" id="A0A162Y3X1"/>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17303">
        <property type="entry name" value="PIPKc_PIP5K_yeast_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase its3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="13">
        <location>
            <begin position="70"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD78205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="459" mass="52879" checksum="1F2BDD04F0EEEFC7" modified="2016-07-06" version="1" fragment="single">PDVAATTSSRLSEDFERELSARRRAFRRWSRHRSLYADDNEDEEYGEGTGTGAGTGGGDRVMMGTRISEGHQNYVLMYNMLTGIRIAVGRVSAKTSRPIEDVDFKAAHKLAFDVTGDELTPGAKYDFKFKDYAPWAFRHLREKFGIDPADYLISLTSKYILSELGSPGKSGSFFYYSRDYRFIIKTIHRTEHVFMRKILKQYHDHVCRNPNTLLCRYYGLHRVKLPHGRKIHFVVMGNVFPPNKDIHETYDLKGSTFGRFLAEEEIRKNPYAVMKDLNWEKRAKELQLGPSKRRMFVVQLLRDVKLLVGLNIMDYSLLIGVHDMIRGNKDNVRDSTLQFFQPDTKSAERRASMMKRRESKADVFRKVIAEANPDPLDVSELPDGLRSNCVFYSNEGGFQATDESNRPLPTLYFMGIIDILTPYDIKKKSEHFFKAMTQDKNSISSVKPAVYGKRFMSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YA73</accession>
    <name>A0A162YA73_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_139367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297375.1">
        <property type="nucleotide sequence ID" value="XM_018430206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YA73"/>
    <dbReference type="GeneID" id="28991112"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139367"/>
    <dbReference type="InParanoid" id="A0A162YA73"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD79335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="353" mass="39342" checksum="AC695F489A5050FE" modified="2016-07-06" version="1">MIDFVHACCHLVKPSITFDDINTVHRHLEKFYEKCNKVYTTKILTSLFLPVLSKFVYSSTPVLTLISASSTIVQLPFILQAFVDSSETTRIPILGKEPLPRTSFPPLEKSFQTMVNNHQSIAPAPSPEYTELLRRLTAIEESLKTMDSNIGIVIKGNKDSLEILDSIANASGERLAVIAPTTISAFASTFFGIPSATPSVAPSVGPVVLTGANTGKLSKQDRTRVLLMHDLHAYLAPKVVGTSVQKHFDCCKLTYHTFKTEIDVKVGKSCNRLLQKEAMSEGKSKDNMPEVLSNCAICTYNHFLMVVDDFIRNHMDFNLCQMLKRSFGRDAVLAVLARLTSLLPHWDFRDEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YC45</accession>
    <name>A0A162YC45_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Probable glutamate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHYBLDRAFT_121302</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297685.1">
        <property type="nucleotide sequence ID" value="XM_018428788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YC45"/>
    <dbReference type="FunCoup" id="A0A162YC45">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162YC45"/>
    <dbReference type="GeneID" id="28989694"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_121302"/>
    <dbReference type="InParanoid" id="A0A162YC45"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00807">
        <property type="entry name" value="GlnRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000070">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000004">
        <property type="entry name" value="Glutamyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="entry name" value="Glutamyl-trna Synthetase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.800.10">
        <property type="entry name" value="Glutamyl-tRNA Synthetase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="16">
        <location>
            <begin position="212"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="17">
        <location>
            <begin position="518"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="18">
        <location>
            <begin position="622"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="717"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="721"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAD79645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="740" mass="83842" checksum="22B4C33A36372265" modified="2016-07-06" version="1">MSIQLIVATKASPISYGVLAAAEQVNAIKPGAITIEYPDTKTLEAEGGATAVAKFNGQTYSSTNAIVRLFGRLHPETGLYDPKDPISSTLVDQWLDFAESKLSISDFKALDATYKELNKHLTLRSFIVGYQLTLADFVVWGALRGSPVFARIVKTKKESLGVYLVRWYEYINTLEVTKNAVEKMQKQDKLKVKSNEQGKFEIGLTEAEMGRVVTRFPPEPSGYLHIGHAKAALMNQYFADTYKGKLIIRFDDTNPSKEKTEFEDSIKEDLALIGVTSNHVSHTSDFFDQMYELALKMIKEGKAYCDNTDQETMRDERTRGIPSKCRDTPVEKNLEIFEEMKKGTDTGRSFCLRAKISPDDPNGTMRDPVIYRCNLTPHHHTGDKWKVYPTYDFACPIVDSLEGVTHALRTNEYRDRNAQYMWMLENLGLRKVVIWDFSRMNFVYTLLSKRKLQWFVDNKIVSGWDDPRFPTVRGIRRRGMTIEALKEYILMQGASQNVLMLEWDKLWAMNKKVIDPVAPRHTAIVKDKMVQCTIQGAPTTPEFKELPKHKKNPAIGLKKTAYFNKIVLEQEDAKSLEVGEELTLMDWGNAFVRNVEKNAEGDVTSVDLELHLEGDFKKTKKKISWLAFGANLAVDALLVDYDYLITKKKVEEGDELKDLITPVSEFKTPVVADANIKDLKKGDAMQFERKGYYILDSVATATTPATFIQIPDGKAASIASKADEKKTEKPKKEKAEKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZA47</accession>
    <name>A0A162ZA47_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_73710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441029">
        <property type="protein sequence ID" value="OAD65361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283401.1">
        <property type="nucleotide sequence ID" value="XM_018442903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZA47"/>
    <dbReference type="GeneID" id="29003809"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73710"/>
    <dbReference type="InParanoid" id="A0A162ZA47"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="332" mass="38032" checksum="607792E69CC2FAE8" modified="2016-07-06" version="1">MSRNLNNNSVNNAFGEEPSVGSPPRNINDIRTIMLQHSQGTVSNQRPLAPKRARLNLEGDSSGRTRSIHDVYEKLDTMNGVLNTVLKNTSSEKAEATASNAVEQDMSPGHQPTLDQLLRDYLSEEKLYDQYNTNENKNSEGNRLVLKSVTNYLRCQEEGKKVDLPTLQTKIVRHIGNRKLQKKTGEKKQEENRRACLCQQCVKSCERRQSALKANRAHFVNSFGENVDSILHADYMSDLESDDEREEEEQDSSSEKSFFGDSTQAGEAKRYSTKNYFFGWCGDRFVDELDVDYEAAHDKKNNTRPFEHKFKRIRDKRLSKTKANKLPSWSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZGX0</accession>
    <name>A0A162ZGX0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_71939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441001">
        <property type="protein sequence ID" value="OAD66631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284671.1">
        <property type="nucleotide sequence ID" value="XM_018442567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZGX0"/>
    <dbReference type="GeneID" id="29003473"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71939"/>
    <dbReference type="InParanoid" id="A0A162ZGX0"/>
    <dbReference type="OrthoDB" id="10681292at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="587" mass="63749" checksum="664D6C37E5F0053C" modified="2016-07-06" version="1">MLSYPIQLALQTLCLASAFLCALLFAVISSLPVPSVLSMGTSSYRMRIIHKDSEGCLQSFCTSSEVFSSGFLRCGSLGKTLGSMSCPAVSSEIKSAGDVEGLSRSTSSNQQNSICHRMNSTVREDDKHSHMERVAYIPVRHENQGSKCMVRTRLPYYGEDLEEQMFEVLVSKTSPLELIRLASEPLGSDNQSEPYSSGYDEVCVGAPAIECFLALPCPFEQGTFNRHRPSHPLTDEIPSSGQNMILSDISDLTSLLEAMTISDASEDLSAGQNSFANTAQQVGGVGIEVASAIETRWYSENAPWFEEIPQCSAFVGGFFAFVQEEPMDFVSTFDAPLEQMMTDADEEDFDCSMSTISEPETSEMLDVEYDGIVVAGVSTACWYNIHDELAMVPEDLCGDSLMDLAVEVVPGIEGILDHYRDDCLMYWDESLVPKGSAIMMATMFPDSGVAGSFPLDQANMTNKGATCVPQQVAEDLVWSPEKEPRVPSSPLLPGSDSGADLPGQSGVSLPEVEAPEPPTIPGVVVWLTTAPESPVKVLEEEDKEDDDDDEEDSDEGYEDDDEGVTLQDSALADLLAELEESDFDDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZLE0</accession>
    <name>A0A162ZLE0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_73293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285641.1">
        <property type="nucleotide sequence ID" value="XM_018442821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZLE0"/>
    <dbReference type="GeneID" id="29003727"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73293"/>
    <dbReference type="InParanoid" id="A0A162ZLE0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="129" mass="14487" checksum="29932BC4A87CFF32" modified="2016-07-06" version="1">MIESQKLVTHPKGFPTPTAQILFSLKVDFKTFYNVLVRSFCQTADKFVCNEFTTCTNSFRLKCKCNIIFTASAMQALINMVQHKISEVQSASLSVFSVDSACDNSFLMKDIADFADNTAFIIDALRVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163A7P5</accession>
    <name>A0A163A7P5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_147356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289651.1">
        <property type="nucleotide sequence ID" value="XM_018431848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163A7P5"/>
    <dbReference type="STRING" id="763407.A0A163A7P5"/>
    <dbReference type="GeneID" id="28992754"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_147356"/>
    <dbReference type="InParanoid" id="A0A163A7P5"/>
    <dbReference type="OrthoDB" id="2262863at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="953" mass="108786" checksum="E17E81D7C34DCF9E" modified="2016-07-06" version="1">MTTNTVLDKPEQAELIVDNTILDANAFDYSSDEDDSFSIGDEEDNIVDEENNIVNNFFDIEMNSNPVFNAFSDMFSSAAAADEISMTDDNSEIPEEVFETIGTVNDPTSCYPFCDLQTMILFAFINGDNDMISQQMLKKILLAMNLIIKIQQETSIGRTFKLTCLDALLNYQARKKFKMPVFPSQRISVPGSNGNAFTHINLPSDHLRFLMAKPKKSKLILSMPDCTPNQSICLEQGEKWRIYHLFQQPMHTVNANKNIFAREYLVRAIWIVCYGVEVAVTNLRVEQISHVDTTPVERDHYYSISSSLIRLSPAHDFLLFGVHPMEKPMPLSVLPGNVDCDAVFYKVRIVSIILFTNDTSGNCSKQYILFESWLMRCAALPFKDRNLIANIQFLSTIPKKDGTNGMSLLPVIVDDFKKLKKGVKMFSTEDNAYVLVVAPIVWIEADMPYHLELCRLLGPATIFPCRRCYIKLRHAKDFVKDLFYFCESHERRTQEHYVLANSTPDRDTEIPNAPKIRRNTPANEISFRDCSTGRLLELWSFDPEKSKQDVCLKFAKQKSGTGIERFIKDNNESLFYYTFFGGLKELKNNNDSGDIEDDAIQNNSFDAFVFRDDPISRPCIELVSGSVVKFLSIVPRMDNDRNNNYVKTVMTGEHSDIANMNLVCKLDLHIFHNPFYIPRQRGRSSHPAAVTESHVETIDKSISDNKATGIGGVEDDASDSNVKESSLESTRHMQKIGYICANFFQDFTNDPELDELPHGFNALNFQEPTITCTAPSGRITRKHLGSSQPLEVIEEEITPSEEPLIDIPTSVNHSVLPHHAQQLNNNSLNSVLDVMASLHTAIREEIRLSTQNFMESYLDTTEERAEKKRRVDEEFEMWARHTAAYEKDVETRAREAARREREVEIKAVDRERKARRDEIFLLEQKRMNDILAGIVQQTDKDNNTWNNSVVNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ALK4</accession>
    <name>A0A163ALK4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_167754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292381.1">
        <property type="nucleotide sequence ID" value="XM_018435715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ALK4"/>
    <dbReference type="GeneID" id="28996621"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167754"/>
    <dbReference type="InParanoid" id="A0A163ALK4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="277" mass="30971" checksum="032718D91D07C759" modified="2016-07-06" version="1">MSSNTQQSKKTKKTTTKKSVQQTTGTAASTRQREILPSLTVSTELDGTVLSTLSTMSTRLNESHSLLEKVYHNMGATNGQNNNSNHSPIGQTLTTGEYIKCRLPTVLRLIRSQTRAVLATMSVTVNEGAFSTSNRPIADVVQSYTHQQAEGKSFARKDSSTKSDFSTPVQKEKYYKAIHLADKANLESKFGKTVVDLLDYDMLSDIESDEEKNKTRYTPRNRHPLVDEYFTVLKKQRLANKGPDVIGNSVYPIILRNTELSNEKKARVAAWIHTCHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ASM9</accession>
    <name>A0A163ASM9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_166759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293561.1">
        <property type="nucleotide sequence ID" value="XM_018435477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ASM9"/>
    <dbReference type="STRING" id="763407.A0A163ASM9"/>
    <dbReference type="GeneID" id="28996383"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166759"/>
    <dbReference type="InParanoid" id="A0A163ASM9"/>
    <dbReference type="OrthoDB" id="2277222at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="292" mass="32917" checksum="437E4EA9EC556A49" modified="2016-07-06" version="1">MATLTAVGACRSGFSLLLSSRLFKTFIRPKFEYGLAITCLLQKDVLLLEKIQDKCLRMIVGGHATSSTAVLKHICNLPSMAFRVDILKTKFCLRAHTLPSGCLLSLLHSHHLQASTLSTLHTNPLFASIPPDLNCSSRIKLSKHFESFRQEKFAHFRLTNTKILIQACRPLLEVDPVLFLPATCIERGRLVRWRMGWLPGKPKECACGFDHTSRRHLQFCITIPSQLFSQLPAPPTDEDNIIDFAISALPISSTHPSPLYWKALLTILWHIDMLCNPNGNYTHETDHGSLWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B0W9</accession>
    <name>A0A163B0W9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CYP509 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_141511</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295681.1">
        <property type="nucleotide sequence ID" value="XM_018430604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B0W9"/>
    <dbReference type="STRING" id="763407.A0A163B0W9"/>
    <dbReference type="GeneID" id="28991510"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141511"/>
    <dbReference type="InParanoid" id="A0A163B0W9"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF50">
        <property type="entry name" value="BIFUNCTIONAL ALBAFLAVENONE MONOOXYGENASE_TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD77641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="523" mass="59530" checksum="02A1D7874FFBA3C0" modified="2016-07-06" version="1">MDTINHISPSFESYITVFAKIVPKGFYVVAAVALFLCKKVYDFTAAPYKLRHFPKVSFFAFSKSIFSAESVEHRTKRLISPLLHKYKGFYIAKFPLYWTVFVTEPHAVQYVLMKGEIFPKKTRFMNTLNKDSLMIRLFGSSNIAFASGEIWKHQRKIMNPAFHRTAPIELFGRMIPDMFRLIDKSNGNIMLADLLHRITFDAMGKALFGFDFKTAREENSEWTSAYNDAMSGISAPILNITPSLEHITRYLYPDYAKAKKGIDKLTELTLEMVNERKEKIQEAIGQPDDGREKDFLTLIIEAEMKEDKASGSGGLRENLKAFLVAGHASTASSISFCIYHLAMNKDVQNKARKEALDILGDDANISTPTVNECKHITYINMIIKETLRLNAPFGTLFERIATEDVTLSGVFIPKGTIISVDIETIHKNPAIWKSPTVFDPERFSKGGEHDQHEGITWAPFSDGNRKCLGINFSMAEQQVILLMLLKHYEWDLSENSIHKNGIVYDGISLFTPRSLYIKFNKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BDF2</accession>
    <name>A0A163BDF2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_161479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298881.1">
        <property type="nucleotide sequence ID" value="XM_018434406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BDF2"/>
    <dbReference type="STRING" id="763407.A0A163BDF2"/>
    <dbReference type="GeneID" id="28995312"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161479"/>
    <dbReference type="InParanoid" id="A0A163BDF2"/>
    <dbReference type="OrthoDB" id="2404451at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD80841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="810" mass="92240" checksum="5EFC591372C238C2" modified="2016-07-06" version="1">MSFSNASQQRDRISTQQYQCDQCVLFFDNYQKLQNHKRIHRGDSATMTEIDQSILDDVDMYHDENDTSNEDESVSNSEYTMESMELDNTISYKCACNFEDSEGEAHIYDSSQVSTNTFTKAELMSIHLSQLMLQHRIARAAYRDIVQFINTVIRDHDDIMMERGAKISHGETVDALLKSKSSVKGHEYDVCSSGCRLYGINDDQESCVDCGKPRYKTDPNQSQTPAASMKLMSVGDMLSQMLADPATRELLCYRANRESVAGQLTNIFDGDNYKQLVQQGLFSNPDDIAIGLYTNGFVNQKKGKNSYTIIHCIIFNLDPSIRWHDMYFDDISAQLRPLEDFKVGNPSKNIYQPSIYTQLSTFSGSSFFALDELHLIARGIGKLVYDLITITLTKETKFFYTHPDNTLNTTEYPFHIPRADLVTIGNCITSSRKYILTSFQGSFDNVFANIDGTRAVDWLDFLLYLVPTLVVPYLPNRAVKTALLSLVKGCVLALQWTLTSELLDEMESVFQPVQHYLVHIPYIIKQQGPLRCYSTCSMERVIGIFSKLIKSKSKGGRNASFLVERFAIHNYTSTAISICDEINLIRPKPYGRESYMNLPNDPSGAQLWEPFHQFVNLNDDLVEGVGGPSVKEALLKYYWRTTGLTGHEFGDSVVIVAARLWMDLTVYSSCMYRRKKNETSHGNHYVMFTCPYRNNRNVIVHSWLVGTVQFYFQHVDFYGFPHFLAFVEVMKEHDAAGHDSSVPIVKQRSQSTRTLGHQTQPTYAVISVNDICHQVGLVQYPPNGNQFYVIAPYYIFNNNMRITKGNLSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163CRP1</accession>
    <name>A0A163CRP1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_80623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441017">
        <property type="protein sequence ID" value="OAD65110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283150.1">
        <property type="nucleotide sequence ID" value="XM_018443601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163CRP1"/>
    <dbReference type="GeneID" id="29004506"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_80623"/>
    <dbReference type="InParanoid" id="A0A163CRP1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="173" mass="19719" checksum="E174A067CF04BACB" modified="2016-07-06" version="1">MSAHSREGKCHSRLRITPHLHQEPMEIVTASLPMDRTALGVTFHRSLHRPHHTSATILRLMAARPTRHRQKRFLCTMNRMEELLLKPAVESQISLSPQDLAGRRHSNDCSTDLTKCNLVPTAPPDNDRTANSPVQPRDHTGIPQDIVATQEFHVEAIHMQDIKRCFTETELNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163CUM5</accession>
    <name>A0A163CUM5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_153175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441008">
        <property type="protein sequence ID" value="OAD65700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283740.1">
        <property type="nucleotide sequence ID" value="XM_018433086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163CUM5"/>
    <dbReference type="GeneID" id="28993992"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153175"/>
    <dbReference type="InParanoid" id="A0A163CUM5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007842111" evidence="1">
        <location>
            <begin position="19"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="117" mass="13465" checksum="075B2DAC7A119CA0" modified="2016-07-06" version="1">MLGMQCCYCLQLVTEVLAAHFTGSDLTKAEIMYRTVDKITRELVHYSFFKYSENHSAIPSWVVLQIIKKKTIMTSSLEENAALKNIALDRFETSREHCLCSLRSEELPNSMEDLINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163CXM9</accession>
    <name>A0A163CXM9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_175162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441003">
        <property type="protein sequence ID" value="OAD66350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284390.1">
        <property type="nucleotide sequence ID" value="XM_018437432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163CXM9"/>
    <dbReference type="GeneID" id="28998338"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175162"/>
    <dbReference type="InParanoid" id="A0A163CXM9"/>
    <dbReference type="OrthoDB" id="2297906at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="303" mass="34438" checksum="B95271F2FEE273A2" modified="2016-07-06" version="1">MSSNTQQTKKTKKTTTKKSVQQTAGTAASTRQREIFPSLTVSSELDGTVLSTLSTMSTQLNESHSLLEKVYHNMGATNGQNNNSNHSPISQALTTEEYIKYRLPMVLRLIYSQTRAVLATMLLTVNEGAFSISNCPIADVVQSYTYQQAEVKSVSSAVMEEKTRRYISYMLQRAKALPEKIARQNRISRRQSRKRNILADYKAIYLADKTNLESKFGETVVDLLDYDMLFDIESDEGKNKIRYTPRNRHPLVDEYFTVLKKQRLANKGPDVIGNSVYPIILRNIKLLNEKKACVAAWIHTRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163D8M9</accession>
    <name>A0A163D8M9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_21541</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287600.1">
        <property type="nucleotide sequence ID" value="XM_018439762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163D8M9"/>
    <dbReference type="FunCoup" id="A0A163D8M9">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163D8M9"/>
    <dbReference type="GeneID" id="29000668"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_21541"/>
    <dbReference type="InParanoid" id="A0A163D8M9"/>
    <dbReference type="OrthoDB" id="10049244at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF10">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="165"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="169"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="196"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD69560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="490" mass="56022" checksum="F97D17B8530763ED" modified="2016-07-06" version="1">MLYDKVRGISSDPKAQYTKQLENATHYEEWAEAATMLDELEGKSFFFLFCLEKWKQDPRSPDYDWELVKTRLEQLRHIRESGQGQSSMIFALRTSLARNLGDIGNSTLYSHTRVGTKHLISDYIDEVVDQFNWLCDEPSDDPELDLKAKHDFFMNIRQSFGRTAILLSGGGTLGTNHMGVLKCLHSARLLPRIMSGASSGSLMASFICTRTDDEIVELFKNFSDVDLFEKEGKPETPWMRLHRLITSGQLYDINILIDALRSNLGDYTFQEAFNRTRWILNITVSSSTNYDMPQLLNYLTSPDVVIWSAVAASCSVPFFYTSSPLYAKDKSGKIVPWNPVDQLYIDGSVENDLPMTRLSELFNVNHFIVCQVNPHVIPFLQKDNKPPSKVRQAANFCMHLAKTEIQHRCTQLTELGMMPHALYKVQAIMSQKYSGDITIIPDIGYSDYLKVLSNPTPALIVEAITRGERATWPSKKERKKYIYIYHMNVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DG05</accession>
    <name>A0A163DG05_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ISXO2-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_73821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289030.1">
        <property type="nucleotide sequence ID" value="XM_018442924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DG05"/>
    <dbReference type="GeneID" id="29003830"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_73821"/>
    <dbReference type="InParanoid" id="A0A163DG05"/>
    <dbReference type="OrthoDB" id="2278611at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053164">
        <property type="entry name" value="IS1016-like_transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163">
        <property type="entry name" value="DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163:SF2">
        <property type="entry name" value="SI:DKEY-17M8.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ISXO2-like transposase" evidence="1">
        <location>
            <begin position="90"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="262" mass="30304" checksum="59644310D87A40B9" modified="2016-07-06" version="1">MNYQSSLSVRPLSIPPLSYVMASTYTSEVAKQYLIAQSTLYSRNHIVFTCSGGSSMDYILEKDRGYSYRYSEVNSMGATCCIDANSQFVIVEIDESKFGKRKYHQGHRVEGVWVLGSIEKTAERKTFLMTVPHRDAATFLQVIKKYTAYGGLASVIDMNYTHRTVNHNVEYVTSDDIHINTIEGLWNGIKMNYKARLQTKQMVPWMLMEFIWRKKYENRLWQGILKILAEVSFGSIVDNPIYTNYEYLEDDEDEEYTDSTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DN76</accession>
    <name>A0A163DN76_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_159161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290540.1">
        <property type="nucleotide sequence ID" value="XM_018433927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DN76"/>
    <dbReference type="GeneID" id="28994833"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159161"/>
    <dbReference type="InParanoid" id="A0A163DN76"/>
    <dbReference type="OrthoDB" id="2273311at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026960">
        <property type="entry name" value="RVT-Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13966">
        <property type="entry name" value="zf-RVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase zinc-binding" evidence="1">
        <location>
            <begin position="32"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="180" mass="20457" checksum="F74A0928CD0E01CE" modified="2016-07-06" version="1" fragment="single">MFPIIPRKPFSPKTFRTLCTPSPDNPVPPLHTHQWRTFWSAPIHHSVRSLWFRALHNKLSCRSVLHQTVPTIFPDGSCPICGDIKESTSHFLFTCPPKFSAWTIFWSTHFGNVPSTQDIHSALFSFRLPPSLTPDIPAVSLVSCILLAIWRHHWSFVFDDAPFLSTSVLVTAASLVTRFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DT56</accession>
    <name>A0A163DT56_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_168603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291290.1">
        <property type="nucleotide sequence ID" value="XM_018435902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DT56"/>
    <dbReference type="GeneID" id="28996808"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168603"/>
    <dbReference type="InParanoid" id="A0A163DT56"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="141" mass="16918" checksum="AE38B42F11AEA9C4" modified="2016-07-06" version="1">MSHLPGVLFFWKDSERPIDMILLQSDQSESFGKEEHLCYWQIRLTGIAEDIILSFSLTLRFSSNQYSFTITEILIWLKLKKFLRGRIEDLRLGTKICENLCRFCLFRKDFVSKFDKVPTLNYYCYLYYFGSEKLYDWGQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DVL4</accession>
    <name>A0A163DVL4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanylyl cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_181320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291740.1">
        <property type="nucleotide sequence ID" value="XM_018438452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DVL4"/>
    <dbReference type="GeneID" id="28999358"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_181320"/>
    <dbReference type="InParanoid" id="A0A163DVL4"/>
    <dbReference type="OrthoDB" id="206796at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018616">
        <property type="entry name" value="GUCD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31400">
        <property type="entry name" value="GUANYLYL CYCLASE DOMAIN CONTAINING PROTEIN 1 GUCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31400:SF1">
        <property type="entry name" value="PROTEIN GUCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09778">
        <property type="entry name" value="Guanylate_cyc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="29270" checksum="AEE7882732582837" modified="2016-07-06" version="1">MGLRGKSVAVVESGSDQPKNYEHFANHRVAHIIQACYNHENNSNWDCGIACIAMVLQGLGIRCSLRSLAEQCAVESVWTIDLAVLLRNNYEGDFTYYTSYFGSRREHQENKFYQDDFDEDERRVNKLFGSAKSKSIHVVRMMLPMDDFKRFLYCQRFVIVVLVNARLLKCQKCREQRNCVVTVCGQFDFFFEKMKGYDYIGHFICLIGYDPTENLFIYRDPAVVYSYCTISAEDLDNARKASGTDHDCIVIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DWC8</accession>
    <name>A0A163DWC8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Elongation factor 1 alpha-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_133571</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the Dom34-Hbs1 complex, also named Pelota-HBS1L complex, composed of dom34 and hbs1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291850.1">
        <property type="nucleotide sequence ID" value="XM_018429579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DWC8"/>
    <dbReference type="FunCoup" id="A0A163DWC8">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163DWC8"/>
    <dbReference type="GeneID" id="28990485"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_133571"/>
    <dbReference type="InParanoid" id="A0A163DWC8"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16267">
        <property type="entry name" value="HBS1-like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04093">
        <property type="entry name" value="HBS1_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000070">
        <property type="entry name" value="Translation elongation factor EF-1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000204">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015033">
        <property type="entry name" value="HBS1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08938">
        <property type="entry name" value="HBS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Tr-type G" evidence="13">
        <location>
            <begin position="222"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD73810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="655" mass="71390" checksum="B7CD7CC2E407D18C" modified="2016-07-06" version="1">MSRHRAVRNLDLDDVLDDEYDDDYNENALDETELSNEDLEALDEGLSYVYSIVGDNCPLTDVEIKEALWYYYFDKEETINWAISTITERKAKEEKLKAKAAKAEAAVASKASKVNQQKEASQKKTVKPIKPQVTTHKDDEDVEYLSDDPNDQLSQDMVALGLGDINASAKRVAQSKIKEAGSNISTPNGTPVDSRASSPLVKIHPSKRIDVLEEYAKRSGEKPKLNLVVIGHVDAGKSTLMGHFLYALGQVNERTMKKYERDSHKLGKGSFAFAWVLDETGEERERGITMDIAMNSFETEHRKFTLLDAPGHRDFIPNMISGTAQADVAILVVDATTGGFESGFDANGQTKEHALLARSLGVQQMIIAVNKLDVMAWSKARFDEIVAKLGSFLVQAGFRKSNLTYVPVSGLTGNNLIERSKDAELLSWYKGPCLLECVDTFKPAVRLLDKPFRMGVTDFFKGGIGSGGGVSVAGPIDSGSLQIGEQVMVVPGGEMGIIKAMQVNDEPANWGAAGDSVLMTLSGLDIMNLSTGCVLCSPLHPVPVTSSFVAQIIVFDIKVPITSGFPVILHHQSLNEPASITKLLSTIDKSTGEVLKRNPRHISKGTTATVKVQLANRAVPLEMFKDNKQLGRIMLRKGGETVAAGVVIEILTYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DZ30</accession>
    <name>A0A163DZ30_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_167725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292350.1">
        <property type="nucleotide sequence ID" value="XM_018435700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DZ30"/>
    <dbReference type="GeneID" id="28996606"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167725"/>
    <dbReference type="InParanoid" id="A0A163DZ30"/>
    <dbReference type="OrthoDB" id="3247418at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="602" mass="68835" checksum="19EBC87E57B3D2B9" modified="2016-07-06" version="1">MSPIPELYNEKCHCAGYSQNDLIYSFVARRTAQRHNKRILTKCYILNAAILTNQPGALKESYTKTNSPVWEGASMSDTEDVSVTNDVISNDNNDDSGSNSNEINEDKSEDNVIELDNNELNSEDPFATPDMPQNPVHRFIATFVVMFASCYVVDKGAVVLIEFINKLLTIYKQDFQLPLSLPDLQRMTGFSAMTKGIKKFVLQLHHLGYLNLVRGTIIDPIHNLFLGTPKRLMNRWIKDEDIQDSDFAAMQKIAETMIVPGGYTSLNSKIGKQFLYMKADKLKFKNWINFVDARCLLIKPTITFNEVNTAHQFLQTFCTRYDELYNAKILTCNMHLHLHLQNTICDFGPVYGYWLFGFERFNELLKNLKTNRKIGFKETFMKIFIEDVHKDDLVKSFLQSTHQTSAFPLLTKLISSFTPATISSIHQCTFRIQSFVKASKDPNVLVKDNEPLPPSAFPLSLKSATTMSDIHYVHLLQYYKVAYNNEQLVHFQQASESPYFVNNTITLLKYINILGQVYKGKGESGSHGSLVQAKFIGSTSEHIIVYTEYEYIEICFPTFSLDDFQCVLPVHGIMLEVATAKYTTRRKVKKMLVIPLPKKQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DZT6</accession>
    <name>A0A163DZT6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_167869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292500.1">
        <property type="nucleotide sequence ID" value="XM_018435735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DZT6"/>
    <dbReference type="STRING" id="763407.A0A163DZT6"/>
    <dbReference type="GeneID" id="28996641"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167869"/>
    <dbReference type="InParanoid" id="A0A163DZT6"/>
    <dbReference type="OrthoDB" id="2221372at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="61"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="362" mass="40192" checksum="2CC4A0989E81F26A" modified="2016-07-06" version="1">MPTTRSSNPIGRPIQNVRFKVYTPPSLAKPSSSAPKASSSSSSSSSSLPVPLPSFLPPIVNNPTSARATTGPAQNRPADPLTALSTTQAKRKRAPRSSAPAPKKPRTPRGYWVLDNKLPHVRGSWTPRKELALLESYAEIFPPLWPKGKRQTAWRQVIDAVNSVAPKDVPLGYDACRRAVERLSKSRRDGTDLEKAALEAIARKEIHEKEIKKNKTRGLEKQKAKEAKSASEVEFVKEIIDNRNQPESGNQNPTGNLDKGNENTTSGQNAAPQVIEIDDDDDDDDDNSNANNKYENDVTTVEDTDSSEAEMDSPQAQRQFRKDMREYARNQEKTMSNIDKTLTNINSTLSNIEKFLDRFTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EFK5</accession>
    <name>A0A163EFK5_PHYB8</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_157535</name>
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        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
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            <taxon>Fungi incertae sedis</taxon>
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            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
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                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="28994539"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157535"/>
    <dbReference type="InParanoid" id="A0A163EFK5"/>
    <dbReference type="OrthoDB" id="2276345at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="309"/>
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    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
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            <end position="137"/>
        </location>
    </feature>
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        <location>
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            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD78370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="309" mass="34600" checksum="9DEA9ABA6EEB1126" modified="2016-07-06" version="1">MHPALIFGLVVCGTIVIYEGVKLTNHLYERYSEQSDYYEHVRTFNEKRRSGRPHSPPYDDNDDDEDDEVLQSAWNRAYSGLRLRRSAHSDSRLSEDGHSDYELSEIERSILDRKKALQREQALLDDAEQELHRRKQSLSSRGNSLLGLDTTHCDNEITHNPFGDDFGRLTDNTSSQSTLSPFADPPFILPPLDTVSTDPLNVSISSTPESPRQQSTISSIPIDREELWAADSDDNQEMEFPLVLGQGVSDSEESWSEVGRELGMTTRRQSQGSIGSHDSNSSGSLGSQTQHSEDGNMSFDMMSVSDNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EHN9</accession>
    <name>A0A163EHN9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zn(2)-C6 fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_62544</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018440982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EHN9"/>
    <dbReference type="STRING" id="763407.A0A163EHN9"/>
    <dbReference type="GeneID" id="29001888"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_62544"/>
    <dbReference type="InParanoid" id="A0A163EHN9"/>
    <dbReference type="OrthoDB" id="1555531at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="115"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="235"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="555"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="254"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="555"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD78700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="704" mass="76521" checksum="FBED905ED1FB0070" modified="2016-07-06" version="1">MELYYGSSFIQPDPIPLQSPFSQDFFNFTDQQPSSSPPSNITEQTFDASAVDLAAAIFPSSPPHSSEPSPFSFLPMNFEVATNPETPHTPHSHEDLSKSPTMPTKRGYKSHVPSACINCKKAHLACDVSRPCKRCVSLNKTDTCQDIKHKKRGRPKLRDSKSSQSQGPNGKYEVMYGTIHMPSFSATSATYSTSSMYEHEPATPIPGHTSAISFIHEPLESFQTPKKIRPAIAISSSQSQSIQPQLQPQPEPQSQPQIQIQLQPHSQLHSQSEQPSQSSQPAPILPILAPAPFAAFSPFLPIEVQPSFTNTFAEPLIKEENQTVTVFMSMEVCCARISDEVTEAWGYYPQELAHRSLYDFVPSKDSDRLACLHRLVLDNAVDVAKQSDPNYQPTQPTERTTSDLFHRTDPILLATPAIGSSRFSDTIHIKKRSGDNELYEVIVFLGGGFGANLHSIGTLTRLYIVAEFRKHCYKIKPFSSHPLSSTFQQKTPISPMIGSSMSSWASSAATTTPPPASSSSLSALSLSISPSSATPPTPSIFTSKKITLSHANSNINNTNLLNQHNPSNKSNASTASTASNPNNNTIISRHIHPDIPKVNVAPMTNTMNGQEMQLPALMPHRFAPIAARMTGSPRGAPNVTHPTQQYFLQTSSSTLNAAASAAVQRTRRTLSIPSSEATMAGTDKASGNTDASGKVGMSIRSLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167J5U2</accession>
    <name>A0A167J5U2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_189609</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441012">
        <property type="protein sequence ID" value="OAD65219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283259.1">
        <property type="nucleotide sequence ID" value="XM_018439685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167J5U2"/>
    <dbReference type="STRING" id="763407.A0A167J5U2"/>
    <dbReference type="GeneID" id="29000591"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_189609"/>
    <dbReference type="InParanoid" id="A0A167J5U2"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF59">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORTER ABCD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="403"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD65219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="620" mass="71111" checksum="1F80A97F26487247" modified="2016-07-06" version="1">MRERRSSVVESLDPLIELTSHDPQPTRTYSLDYIFVKRFFRLVRLLFRPPGNTYRFWSTHREAQQKSIFWLYCTFIFGSCGKEVLVYFVGLMPSRFYSLLTSKDLTGFIAYMFPCFFLVFGIAISLSILNFMGGLLALKVRRLLTEHLQDRYVKPKAMYTLVLNHESVDNPDQRITQDIDKLSESLREIVSTLIIAPLLVAYYTWKCWDVSGFIGPAMIYVYFILGTIISRRLIKPIVNSVFYKELHEGNFRFLHVRLRQYVESIAFSSGEIEENARAHNSLSTLLTYQRSIINKSFPLNCNSFAYIGSILSYMIVAIPIFTGVFDDKDPGELSSIISKNSFVSMYLIYQFTVIIEQSGKLSDLAGYTARVVELLEAMDNVDNEIENIEIDYPYREDDQSETIEFENVSLLSPRSKVVVLGFNLKINKGDHIVLTGPNGCGKTSILRALAGLWPCTKGRVHVPKMKHGKDIIFLPQVPYLVHGSLRDQISYPSIASTIYISDQEIRSLLQQVHLSHLEGLIESFDHAYAQEWNKMLSPGEQQRLMFARIFYWKPRFAVLDEATSTMDTATEDHLYSLTKEFGITLISVSHHPSVYRFHKRHVALDGHGNYTIGDIPDLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167J5V5</accession>
    <name>A0A167J5V5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_153703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441012">
        <property type="protein sequence ID" value="OAD65228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283268.1">
        <property type="nucleotide sequence ID" value="XM_018433231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167J5V5"/>
    <dbReference type="GeneID" id="28994137"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153703"/>
    <dbReference type="InParanoid" id="A0A167J5V5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="196" mass="21926" checksum="D36BD2B556165D07" modified="2016-07-06" version="1">MYKGAFRAMSPCRSRKKWGPIWELNAQRDKGICWFYLLTPVFPRRQNLLNSDKGSVEKDNQCSGSAARLEKNARHLGTKRPELIFLHAKGSVESLYQPSCSAAQHKVPFAIARIASVTVTKTVDTIQKNATIFLHVESGVESKFKPEGSAARQPTPSSKLHSLDSEPLKTQYERIRAIPLVGLAWKLLYDGNETSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JAW2</accession>
    <name>A0A167JAW2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_153318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441009">
        <property type="protein sequence ID" value="OAD65626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283666.1">
        <property type="nucleotide sequence ID" value="XM_018433112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JAW2"/>
    <dbReference type="STRING" id="763407.A0A167JAW2"/>
    <dbReference type="GeneID" id="28994018"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153318"/>
    <dbReference type="InParanoid" id="A0A167JAW2"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="65345" checksum="68D4498BF5FECAA3" modified="2016-07-06" version="1">MTGASGYHDIVFVIDFGTTHSGYMWKCVHTNCAQNYGRGEFDCYLKEKEHPSTMFYKKVDYSKACFGINADVASKKTPDSGYYVSRVKLWLDRTIKEDLPPLPPNMTLVQVIAGYLKQIGLEIREQIPKRHPKCNEPSRYKYCLAVPTMWSEQSKDIMRNAAVLAGLIEKYDGPKKLSIIDETVAAALYAERVSPELKLAHGSLYMICDAGGGTVDLAVFEKDDSPGKNGLKEVTMGTGHSCGSSFLDTRFEALLRERTCRHPEYSEMDLLNIMWKFKYELKPYLYVDDDERSGHIKKINDIYIRKHPNPSKAKKFTVAEIFTKVFEPVVNKVLAMIEIQLTQLRGRVLDVMFITGGFGSSPYLLARIKDICGSRVKNIKVVKNGNRAVMEGMILFEKESRIITRRILRRTYGIKLCSPTDELDDNNKTSTQDKFHVYIRKGYPVNDKVWITRNLTWKKDSLPIISLYAYDGDEPVPEYPTTEDIDLVAIFDTQFPIAENKTTTHQLMAMEMRFDIDKIDVKVNIAGREFKYFTAWDVIEKKQTLAYTELISPAGKMRKWWRIDGAVNCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JFF2</accession>
    <name>A0A167JFF2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_102310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441007">
        <property type="protein sequence ID" value="OAD65887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283927.1">
        <property type="nucleotide sequence ID" value="XM_018427703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JFF2"/>
    <dbReference type="STRING" id="763407.A0A167JFF2"/>
    <dbReference type="GeneID" id="28988609"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_102310"/>
    <dbReference type="InParanoid" id="A0A167JFF2"/>
    <dbReference type="OrthoDB" id="3039677at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="176" mass="19778" checksum="CAE88552D56D9C22" modified="2016-07-06" version="1" fragment="single">NLPRSERYKKENVVLVGLMPGPKEAKTSEINHYLRPLVAELNQLYGGVVIPTVQCPSGALVRSALLLVACDIPATHKNCGFTSHSSTCACNKCNQQFPRLPDSNAVDYSAFVLSEWVPRTDAKNCCDAKLWRMASSDAQRKRLERENGVRWSELHDLVYFNLVECTVINPMHNLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KAT9</accession>
    <name>A0A167KAT9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_151152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285675.1">
        <property type="nucleotide sequence ID" value="XM_018432614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KAT9"/>
    <dbReference type="GeneID" id="28993520"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151152"/>
    <dbReference type="InParanoid" id="A0A167KAT9"/>
    <dbReference type="OrthoDB" id="2288984at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="139" mass="15610" checksum="A3A3A4EF9D7157F8" modified="2016-07-06" version="1">MSTPMPTSIPITTPTICQRTFRLQSFIDYSKNPDLVIKGNEPLPPSVFPLLTAALIPMSNIHYLHLFEYYKTAYQNQALVYYEEASSSLYFVDNLINKLKSVNILGQTYKGQNESGHHGSLIQAKFYGSTGQHVLAYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KDA1</accession>
    <name>A0A167KDA1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_68188</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285856.1">
        <property type="nucleotide sequence ID" value="XM_018441904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KDA1"/>
    <dbReference type="GeneID" id="29002810"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_68188"/>
    <dbReference type="InParanoid" id="A0A167KDA1"/>
    <dbReference type="OrthoDB" id="2596771at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33977">
        <property type="entry name" value="ZINC ION BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33977:SF1">
        <property type="entry name" value="ZINC ION BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="451"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="518"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="531"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD67816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="554" mass="64040" checksum="87089475389886B2" modified="2016-07-06" version="1">MSNPIIYDISNIQNVLVNSSFEVIKMLPFKVVVPVKAKYIFGETRQCHRAGIYIPERDSRPAQKESKACGCNGALKIKQFKKSPTIVTFCMTRDHNNHVPGDRSEIRTLPLPFEAIKLIEDQLRSEAAVEAQEYLSFDRLTAGMTNLLYMFNSDEKASIAIWMNEKLPERSYCIFTGDLRVNNIESNLFAFGFQSPVQVRVTRIATSFCLDATHGISARSGEVMYSLVTQHNVTGKGFPVAYMVTNDQTVRPISQWPMHLCERSYFRPLNITIDCSIPEVNAITSAFPHVAIHYCEFHILRAWQTNLDNKVRLDASFTSAQLAAYKQELKNKLKYILMESNEEVFLTRILDFKRDIPDQLHFLRYFETRWNGSEVLLKRWGRPYVDDSHRRYLTNNYIESWHNQLKTIYFGRARIRRLDRLVFDLTNDVEYFYEQEVDCIHLNNGKMGPSITVVNDLIECCSCPRYISRQVPCKHAFLLKRYRKINVLYTIQKDANHLAMQRPAVLAKEEEEVVIVDEEDSREDAVGAQNDVDTSITDLTSSSKTRSRTHANDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KDU2</accession>
    <name>A0A167KDU2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_79084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285899.1">
        <property type="nucleotide sequence ID" value="XM_018443424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KDU2"/>
    <dbReference type="GeneID" id="29004329"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_79084"/>
    <dbReference type="InParanoid" id="A0A167KDU2"/>
    <dbReference type="OrthoDB" id="2433997at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007889349" description="Secreted protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="15524" checksum="F80971F092D78013" modified="2016-07-06" version="1">MQFSALVSFVSAIFALAIFTAVEAAPASTKVSAACLGFRITSPVASGLKWTYGQCYSVDWDLGASQVKTIKSVDLYSSSTKKKIATEKSNVAGTAGTSGNFPLLMGDDLESGNYYFQVNAVTASGATCTLSTVAFNVNVNPNSPPVTHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KJN6</accession>
    <name>A0A167KJN6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_173255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286287.1">
        <property type="nucleotide sequence ID" value="XM_018436978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KJN6"/>
    <dbReference type="GeneID" id="28997884"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_173255"/>
    <dbReference type="InParanoid" id="A0A167KJN6"/>
    <dbReference type="OrthoDB" id="2259008at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="193" mass="21434" checksum="63F943AB5CB95AB9" modified="2016-07-06" version="1">MPPTPSSSSLSISSPRGILPNSKTVTPSNKTHIQTYGSVLSTPPYLDTEHVYGAHESHLNLEHASSYTTTVGQDNNDEGLYLMWTHELLRERGFTPISCRSEVDEDEEDSNDAGQDSDCQSTDSSVDNSPESYRPQFLFSPAPSFLAESSSSQHYPQNEYTYRAAIRGSQEEDTDPVFSLARLFSLSSFCCFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KWV9</accession>
    <name>A0A167KWV9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translation initiation factor IF-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_136168</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD69068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287108.1">
        <property type="nucleotide sequence ID" value="XM_018429768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KWV9"/>
    <dbReference type="FunCoup" id="A0A167KWV9">
        <property type="interactions" value="529"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167KWV9"/>
    <dbReference type="GeneID" id="28990674"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_136168"/>
    <dbReference type="InParanoid" id="A0A167KWV9"/>
    <dbReference type="OrthoDB" id="361630at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03692">
        <property type="entry name" value="mtIF2_IVc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000007">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000008">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000019">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="103"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD69068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="623" mass="67978" checksum="5970688ED692CE9F" modified="2016-07-06" version="1">MILDRRAKQRAKEAELARQSQEVYIPEIINVANLSRVLGVRIEQIIQTMEELDMGSTSHDRMLNSDESSLIAMQLDMNPVVDSRQSLDLFPRPPTEDTSKLPGRPPIVTIMGHVDHGKTTLLDTLRQTSVAAGEAGGITQHIGAFSVQLPSKKQITFLDTPGHAAFSSMRARGAQVTDIIVLVVAADDGVMPQTQEAIQHAHNSGVPLVVAINKCDKPGVDSSKVKQELARYNVHLEEIGGDVPCVEVSGLTGLNLDQLEETISTLSEVLELKAERNAGAEGVVIESQMEKGRGNVATVLVRSGTLKVGSVVVAGQTWCKIRSMTDHTGKSIKEALPGTPVKVIGWKEVPHAGDEMLPSPDENTAKTVVDNRLARQQRDQQLRDLEVINDKRRAQREQLEQEPTHTCTNTNLPRESELNCFGHPGDVSGTVEAVVDCLNGLQNKLIKVKVVQSGVGNITEGDVLLAAACEGQVIGFNVKADKKIQAEASRHGVNVRSYSVIYKLLEEVKDQLSDMLPPIVTTQVVGEASILQVFDISTKGRETKPVAGCRVTNGAINRNGRVRIVRNKETIWEGELDQLRQVKKDIAEAKKGLECGMSFEGFKEFQAGDIIQCIQAIETKQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L6P5</accession>
    <name>A0A167L6P5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_172350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287757.1">
        <property type="nucleotide sequence ID" value="XM_018436776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L6P5"/>
    <dbReference type="GeneID" id="28997682"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172350"/>
    <dbReference type="InParanoid" id="A0A167L6P5"/>
    <dbReference type="OrthoDB" id="2279974at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="157" mass="18662" checksum="B77F4C9B65A40BC5" modified="2016-07-06" version="1">MTMNIQFLYENGKGSAVDEYGWPEPIKTTRVHVRTGQKWAAQYEKDPESIFEKRRKTGRPRILHDKHKNAILECIDENPSVVLDEVMKNLKHTFTELKVSKTTLFDFVKKNCNLSLKKARLQPIDRNSEERIQEHLDWIHKWDKTDMDFTRNCVFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LAQ6</accession>
    <name>A0A167LAQ6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_60321</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288039.1">
        <property type="nucleotide sequence ID" value="XM_018440628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LAQ6"/>
    <dbReference type="FunCoup" id="A0A167LAQ6">
        <property type="interactions" value="451"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167LAQ6"/>
    <dbReference type="GeneID" id="29001534"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_60321"/>
    <dbReference type="InParanoid" id="A0A167LAQ6"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000182">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF32">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="10">
        <location>
            <begin position="121"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="9">
        <location>
            <begin position="324"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD69999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="634" mass="69789" checksum="855E85F1C3C8D7AF" modified="2016-07-06" version="1">MPIYGLTITQRSISSRALIYKALNARSISRLFPNRSYSFASTMSISKQTEVEKSPTTKDMATSPYYNQGITLSEASRAKLGLRGYLPSAVESLEKQKERALIMLRSKKTSLDKYIFLAHLRNTNTHLFYKLTCDELEEIAPLIYTPTVGEACLNYSNIYPFLAPPGSSDGLYLTLNDLPNIEEIIRNYRPITGQSGGFSPEIAVISDGSRILGLGDLGVNGMGIPIGKLQLYVAGAGIDPRKTLPILLDLGTNNKKYLEDPLYVGLKQTRPDEDTFYSAVDKVLAGLHTVYPDLLIQFEDWSSEHAFGLLNKYKNKILTFNDDIQGTGAVILSGLMNAIRKVESESKVAPKDHRIVFYGAGSAAVGVATQIQEYFQTEYNMTEDEAKKVFWLVDSKGMITQDRGDKLANHKVYYARDDNNGKQFKELTDIVDYVKPTVLIGLSSSTGAFNSKVLSRLAELNKQPIVFPLSNPASQAECTFEQAMESTNNSVVFASGTAFPPYTDPKTGEIHVPGQGNNMYIFPGLGLGAVLAHPKLISNSMIYSAAKALANSLTPEERGQGWLYPSLKRIRAVSADVAAAVCETACQENLARSQIITNLKTHDEIVKHVTANMWSPTQDTAADTRQDVYQEANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LDF7</accession>
    <name>A0A167LDF7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_159615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159615"/>
    <dbReference type="InParanoid" id="A0A167LDF7"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="129" mass="14064" checksum="02128B83E0736DE6" modified="2016-07-06" version="1">MAGVLALSVSIRMNDTLTFLDINIPPNDLDLAQLQNDIVAVCTRNMQRTFENNKPQTAKEDVESPEISCEPKVTCSSSTISSASSASSGLSHSIEEHPDVASFDYSKQHPSLPINYPLEDISLVDDLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LE51</accession>
    <name>A0A167LE51_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_182544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288295.1">
        <property type="nucleotide sequence ID" value="XM_018438636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LE51"/>
    <dbReference type="GeneID" id="28999542"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_182544"/>
    <dbReference type="InParanoid" id="A0A167LE51"/>
    <dbReference type="OrthoDB" id="5562028at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18393" checksum="995CDBD7EF795963" modified="2016-07-06" version="1">MGCCGSKEDHDQDDLSEPILRNPHTRRNSQPTCPSYDTFDVKMEQDFWKDVIERTTSNLIDISSAQADPLQGQDIQERADKYRWLVDRIAVGITTPCQVMDQDSPVDVLAEAEPNEGMSLEDLDELYQTMDCIQDALHRIQVSPVGDIVVTLTLNESSAMRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LJI4</accession>
    <name>A0A167LJI4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_171343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288637.1">
        <property type="nucleotide sequence ID" value="XM_018436578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LJI4"/>
    <dbReference type="STRING" id="763407.A0A167LJI4"/>
    <dbReference type="GeneID" id="28997484"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171343"/>
    <dbReference type="InParanoid" id="A0A167LJI4"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022111">
        <property type="entry name" value="Rhodanese_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040503">
        <property type="entry name" value="TRHO_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001133">
        <property type="entry name" value="PRK00142.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43846:SF1">
        <property type="entry name" value="TRNA URIDINE(34) HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43846">
        <property type="entry name" value="UPF0176 PROTEIN YCEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12368">
        <property type="entry name" value="Rhodanese_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17773">
        <property type="entry name" value="UPF0176_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="191"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="389" mass="43912" checksum="D7F52A34A4998AEC" modified="2016-07-06" version="1">MNGLIKTASLLFSRSPLWQPTLLGLKPAKSIRPVWSRTTQLSFSCSFSTQTQSNIARFRPVAFYSIVPLSQDRVRELQSEIHSRLKQIDVVGRIYLAPEQGIGGINCQMAVPLSQLETVKSFFQGIREFTQTGPIAFTEGIQDTTTPSFRNLRVVTKRNLVATKVGLQTKDLEMQPDYLDPAVWHEQLADKGNQAFVLDMRNHYEYDIGHFEHAVKMDVDTFRDGMEVMDSLLKEKPKNEEIYMYCTGGIRCSVAGSYLLKKGYSKVKMLKGGVSAYGNYVSKGKNKTSLFRGMNFTFDGRRGERITDDVLSHCFHCNAPCDRLSNCSNTLCHLLFTQCDACQAKMDKTCSTKCKETIEGKIEWTDEYNYHNQIRPTAQKKAVAVAVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LMT1</accession>
    <name>A0A167LMT1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_126213</name>
        <name evidence="8" type="ORF">PHYBLDRAFT_132488</name>
        <name evidence="6" type="ORF">PHYBLDRAFT_136999</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285407.1">
        <property type="nucleotide sequence ID" value="XM_018429824.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288799.1">
        <property type="nucleotide sequence ID" value="XM_018429088.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294508.1">
        <property type="nucleotide sequence ID" value="XM_018429500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LMT1"/>
    <dbReference type="FunCoup" id="A0A167LMT1">
        <property type="interactions" value="704"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167LMT1"/>
    <dbReference type="GeneID" id="28989994"/>
    <dbReference type="GeneID" id="28990406"/>
    <dbReference type="GeneID" id="28990730"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_126213"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_132488"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_136999"/>
    <dbReference type="OrthoDB" id="10255148at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD67367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD70759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD76468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="204" mass="24149" checksum="47E1E388A1B42D8E" modified="2016-07-06" version="1">MGAYKYIEELYKKKQSDVFRFLLRVRCWEFRQMNVIHRASRPSRPDKARRLGYKAKQGFVIYRIRVRRGGRKRPVHKGATFGKPVNEGVNQLKYQRSLRSTAEERVGRKCANLRVLNSYWINQDATYKYFEVILVDPSHKAIRRDPRINWIVNAVHKRREARGLTAIGKKSRGKGKGHRFTKTKGSGRTANWKRRNTLSLTRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LP47</accession>
    <name>A0A167LP47_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_77598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288868.1">
        <property type="nucleotide sequence ID" value="XM_018443277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LP47"/>
    <dbReference type="STRING" id="763407.A0A167LP47"/>
    <dbReference type="GeneID" id="29004182"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_77598"/>
    <dbReference type="InParanoid" id="A0A167LP47"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25499">
        <property type="entry name" value="Beta-prop_pof12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="57"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="538" mass="60893" checksum="5FC022389ADA5F42" modified="2016-07-06" version="1">MAAAKELKQTLKANKYIHKVDNVLLGVEKNKGICRSAMQKPPRKRQRRTPQISRLIDFTSSLLSDEIVLHVFSYLSANDLAQCAMVSTGWSRLANDELLWRPLFLDRFRHRSRLNSCNVHPWKTKYKISHNWRSGNCQIVHSERKQPMPPCQPCIQSIDSILCQSNSGSQIEIWSLKKNRILGYLQALSHQEVPVTCLKLIKTSQEDIYHLVAGYEHGGMAMWEIEIVKGGYNATEWVDYRPSARSADSVVSIAMAYPVVAICTAAMKISLFNVNQNTERKRLGLIYQLQSPVHWTPVELDLKLQKPSAGCIKDRWRLLVCFGMGIGTNAYSIGIQASASHLDKNLTELLACFLFKTNEIIVSLHTLISSRHCSALDQDTFFFTPNLTNTTQPPITAIAYDAPFLATAHANNTIRHYRVDITPDVFNLVFLQTLYGHTCMVTALTLDGPARRLVSADRTGLRIWDLACTKGVPMDRSGQLIKWHQGVDYLVRLDLEHDEDYPWQIDWLCSDATKIVALKRPLVPDAAMSLVVWSFGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M8M7</accession>
    <name>A0A167M8M7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_7220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290169.1">
        <property type="nucleotide sequence ID" value="XM_018442615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M8M7"/>
    <dbReference type="GeneID" id="29003521"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_7220"/>
    <dbReference type="InParanoid" id="A0A167M8M7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="52" mass="5695" checksum="7A0594821AE1CE94" modified="2016-07-06" version="1" fragment="single">LMNLCPIALINSDAKVFTHLMNAHMISAVTTLITPYQTGFVQGRFIADNGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MG56</accession>
    <name>A0A167MG56_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_65321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290796.1">
        <property type="nucleotide sequence ID" value="XM_018441435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MG56"/>
    <dbReference type="STRING" id="763407.A0A167MG56"/>
    <dbReference type="GeneID" id="29002341"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65321"/>
    <dbReference type="InParanoid" id="A0A167MG56"/>
    <dbReference type="OrthoDB" id="10419778at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="497"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="305"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="667"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="550"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="576"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD72756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="726" mass="82608" checksum="47968221A53CF131" modified="2016-07-06" version="1">MTTSYSANSGEWHKRVSSFHAVDLVTLDSSILPASISRTLRDALDGRDTTVVVNHEKSIKSPTTPATITATITSSQQTLQLRTVPSLENIGHCNNHNYYNNNHHKHHNPTQPILTLPMGPEIERISILEQALEEANQKVHQMNNHLWEHEQGTQITLGLRLEELEKTKLQLKTLEQIEEKQTAIIEQLLNKQDSMEILLKRQQIHSVKMMEEFARAKADTTKYFQHKIEHVVKEVTRISAVRQDLEKRMSDIQDQKILEKRSSDIDLQRTMALEGRVEELDMIVEKLDFQKKRTSAALTRKTSAYRQMEQCLQRHTEIIKTYEQKIKMLEKAALEASQQRVLSPNKDASDLLDESDTTTVPLPASVPVSVPANPGEKSVICHEACATKHQDGPHNSTNSKKVSARMENGYHWQGQRSLRHSHQPTRSILKKCDSSVINRLDEQALQKQCQEWLDEGKGETLVYKIVEICKDNKYLIVQMQDMQNELNLWHQHAAMLRDAQRHSNPKKPTSASTSTSASTSTLASTHTPTSKKHRHDCESRLDHTSHRTQLRSTDNSETMHSYPSYKLNNSSQNLNLPPPTAPPSNPPPPIPSSPSSRHSTKSIEKENNNHNTTTTTANRSSQHNIRDLKRRLSHAEAAAFSMAKKLDAVLHEKEGLNLETSRWRAEVDKLLEAQAEKEAQAAKVQQELEKQLEEERALKAKSEKARQVLESQTDAWLSKKSVFKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MLT1</accession>
    <name>A0A167MLT1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_65824</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291264.1">
        <property type="nucleotide sequence ID" value="XM_018441537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MLT1"/>
    <dbReference type="STRING" id="763407.A0A167MLT1"/>
    <dbReference type="GeneID" id="29002443"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65824"/>
    <dbReference type="InParanoid" id="A0A167MLT1"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060258">
        <property type="term" value="P:negative regulation of filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001382">
        <property type="entry name" value="Transcriptional repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="222"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD73224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="376" mass="42014" checksum="F9B838E869DDD42F" modified="2016-07-06" version="1">MSDSYLPIKNASGKHINLLNDQPPAGSSENKKFKVFSNQSPEDQASVTRRRYHCPEPMCDKSFTTSGHLARHNRIHTGEKNFQCLHPGCLSRFSRQDNMMQHYRTHISPKSRRHSHQRQHYHLMSHPYHRPTSPLEYYHHNTNSNPNPSRSPNYTRLYSDNRSVYLSESPYSQPLYHSLPPTTTSSAPKVVMTKVEPGLTNLSDQYNSHLPVHPVHVHRHQVYSHSAPPHSTSHGYLSPSRSIDSSPHGRLPKPQPIEPFMGPGAGVETGVIIPGPCPGSGLSSGLGSGSSVGHRNSHPRSVSSSPSSSSSPFLFSPLQFHASPPLQMAPYQPPDSAYNYPSYQSRPRYSVYSPPQHKLMSYDSYHSLPCTISSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MRE9</accession>
    <name>A0A167MRE9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_145127</name>
        <name evidence="4" type="ORF">PHYBLDRAFT_145139</name>
        <name evidence="3" type="ORF">PHYBLDRAFT_168096</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291692.1">
        <property type="nucleotide sequence ID" value="XM_018431371.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291701.1">
        <property type="nucleotide sequence ID" value="XM_018435796.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291704.1">
        <property type="nucleotide sequence ID" value="XM_018431376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MRE9"/>
    <dbReference type="GeneID" id="28992277"/>
    <dbReference type="GeneID" id="28992282"/>
    <dbReference type="GeneID" id="28996702"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145127"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145139"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168096"/>
    <dbReference type="OrthoDB" id="2301633at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD73661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD73664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="142" mass="16229" checksum="3644F1255D489DD4" modified="2016-07-06" version="1">MNTVPHSIHSPWLKHKTQATKALNPGTEQARDPANRDFQNEIRTIPERYQKSSQPDQTSQQDHRGPKTTQNQGLRKPYSYRNHHSQISASDLRGSQQEPYEQKVQANPTVVQAPPSNVYKQQIPEANRIENQSSTTTGYTHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MWL2</accession>
    <name>A0A167MWL2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_167703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292324.1">
        <property type="nucleotide sequence ID" value="XM_018435695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MWL2"/>
    <dbReference type="GeneID" id="28996601"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167703"/>
    <dbReference type="InParanoid" id="A0A167MWL2"/>
    <dbReference type="OrthoDB" id="185493at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="116" mass="13291" checksum="17EF7A449E302717" modified="2016-07-06" version="1">MSDTPLEINTQGTAAKILSETVAQKRFITVWHRKTQFNDGRVIDWDIVGHNTPYPTFVTVFTFDTDTKTTCILKEYAQGTNEISSSVSSTRTFGRGQVDWRRMDQSITRGPTRWNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N9D3</accession>
    <name>A0A167N9D3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_166646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293440.1">
        <property type="nucleotide sequence ID" value="XM_018435453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N9D3"/>
    <dbReference type="GeneID" id="28996359"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166646"/>
    <dbReference type="InParanoid" id="A0A167N9D3"/>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="108" mass="12168" checksum="FCA64F147318024C" modified="2016-07-06" version="1">MIQTFIDDVKCNTKASNSEEKVSNRSSDIPFIQKRLMQILIGVVVAFWLGYLTSSWGLLDHLIHQTQFLYIIGALSTAYFIIFILLERIAESEAQQVSEIIGSTSALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N9U2</accession>
    <name>A0A167N9U2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_166674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293470.1">
        <property type="nucleotide sequence ID" value="XM_018435458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N9U2"/>
    <dbReference type="GeneID" id="28996364"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166674"/>
    <dbReference type="InParanoid" id="A0A167N9U2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="172" mass="18560" checksum="22C10DFAD17499FA" modified="2016-07-06" version="1">MSFSTVNTIKANLRSASAFRLLSSSTVGAGTPAVTAVVAAKAATAAAVAVGAGASNTVQYRSFYRTILEPKDDIQDMLNVIESLKADIASLENTYHLKQNAPPPTLKTSQREPEELQSDVLENVITEASFYRTTEDDGQTRTHSFEAVHISTPTNSPRVGFEDAIVSDYFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NFT6</accession>
    <name>A0A167NFT6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA topoisomerase</fullName>
            <ecNumber evidence="6">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_142785</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="6"/>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293834.1">
        <property type="nucleotide sequence ID" value="XM_018430871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NFT6"/>
    <dbReference type="FunCoup" id="A0A167NFT6">
        <property type="interactions" value="921"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167NFT6"/>
    <dbReference type="GeneID" id="28991777"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_142785"/>
    <dbReference type="InParanoid" id="A0A167NFT6"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.140:FF:000003">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="3"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="9">
        <location>
            <begin position="166"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="603"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="674"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD75794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="683" mass="77657" checksum="E7CD8A8AF935A86F" modified="2016-07-06" version="1">MRKIICVAEKPSAAKAIAGILSNNNFRTSPTDDRYVKNYEFEYSFDNRPAKVIMTSVRGHLSEFAFAGKANKEWYSCEPIALFKYPISQNVAEDYSGIEKNLKILARSASVVYIWTDCDREGEAIGGEVADVCLSVNSHLEIWRARFSAMQPAAIQRAAQNPARIDQRQVDAVNVRSELDLRIGAAFTRIQTMRLRHMVGDRKVLSFGGCQFPTLGFVVDRYLDIQGFIPEIFWKIHMQHTKGTNGQEQTTQFNWKRNRLFDRHATYAIYERCIINPVAVVTKLDTRNVSKRKPLPLTTVEMQKTLCKILRMSGEHIMKIAEELYTAGHISYPRTETDQYDSTFEFQPIIEQHTEDSQWGQYARLLMGQSFERPRNGSNNDKAHPPIHPTAYTNTLSGDHKKVYEFIVRRFLGCCWRDAQGSETNITVSIETEEFGAKGLMILERNYLDVYTYDKWSGNILARYDLHERFTPTVLDLRDGTTEAPNLLTEYDLISLMEKHEIGTDATIAEHIQKILDREYAFKVNQYFRPSSLGISLVLGYDAIGFESSLSKPHLRREMEADLKSICEGRKEKTEVLQTSLERYTDMFVKLLREFSTMTHSITVNFNPNETPPPGAEIQRSRAFQRPSNETPTRGGRGRGGRGASGGSRGGRARGGARGRGRGSERGRGPSRAPRGRRGRGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NK80</accession>
    <name>A0A167NK80_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_75979</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="5"/>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294168.1">
        <property type="nucleotide sequence ID" value="XM_018443110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NK80"/>
    <dbReference type="STRING" id="763407.A0A167NK80"/>
    <dbReference type="GeneID" id="29004016"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_75979"/>
    <dbReference type="InParanoid" id="A0A167NK80"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="11">
        <location>
            <begin position="128"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="10">
        <location>
            <begin position="402"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD76128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="607" mass="70767" checksum="B454FDA3D867032C" modified="2016-07-06" version="1">MITVVDVPLIHYIKDFCCSFSLTSTPFRDQELYPQVALYQDIEDAVYNDDFLYNKLEDLLESFDDLSEYIESGGETRTFPPQEFELMSFASYKSDPRHKDLTFPPLDVNQHPKAFLIVYIPNQGAHDLSLEINQLYKSLLPKPEDITKRQNIVQRIENIIGGAWNQNYKVKVYGSSANGFGFRDSDMDLAIVAPEYDYPWINKRKESRKQHSIMNMHRLAFILRNSGMINVMPVPNANVPICKFDVLPHRIHCDISVNNLMSSTNTRLLKAYSELDPRVRPFIYAIKEFVKRRNINDASNGSLSSYSYTLMGLWYLMTCDPPVIPNLQNPKDFFEGQCNTEDCNSHTKNMVETEYKHSYIHCNISFHDCFKRTSLKRNGFKEIRYTRNGTFWATRNVAKLDQLLIDFFYYYGTRHNFNRAISIRLNRSMFKRNQWDNQPIAIEDPFITRRNVGTSCHKKELALIKRLFSATAHTLATKRFSFASVCSMLYSDLVKAGSLKMAKMTTLGRCQADRLPIEKAVIISDVPYYYERDMVTDMVMSELSVYGEIESIKRWKLYRKEGSKNYIVNISNFDPFVLLPVTIPSMDQENVSFDVTEYYEIFPNYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NVW8</accession>
    <name>A0A167NVW8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUS-like FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_142231</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294758.1">
        <property type="nucleotide sequence ID" value="XM_018430763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NVW8"/>
    <dbReference type="FunCoup" id="A0A167NVW8">
        <property type="interactions" value="579"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167NVW8"/>
    <dbReference type="GeneID" id="28991669"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_142231"/>
    <dbReference type="InParanoid" id="A0A167NVW8"/>
    <dbReference type="OrthoDB" id="10262250at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052582">
        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="9">
        <location>
            <begin position="13"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD76718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="238" mass="25988" checksum="E83B7014018B1F0E" modified="2016-07-06" version="1">MSGTSIDYSNKVILAPMVRVGTLPFRLTTLAYGADLVWSEELVDKRVIGSVRRVNPATNTIDYYKGTSLTFSTHADEAGKIILQLGTADPDLALEAALTVKQDVVGIDVNCGCPKKFSIQGGMGAALLTNPEKLKKILVNLVNNLDIPVTCKIRTRDQRSTEKANWEAIKDVVNTVKSIPVILNGDILTQEDIPRARELTNVSSFMIARGAQYNPSAFRKEGLVSYEEAVEAYLKKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PBV0</accession>
    <name>A0A167PBV0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kaptin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_141494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295659.1">
        <property type="nucleotide sequence ID" value="XM_018430601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PBV0"/>
    <dbReference type="STRING" id="763407.A0A167PBV0"/>
    <dbReference type="GeneID" id="28991507"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141494"/>
    <dbReference type="InParanoid" id="A0A167PBV0"/>
    <dbReference type="OrthoDB" id="10267127at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029982">
        <property type="entry name" value="Kptn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15435">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN KAPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15435:SF2">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN KAPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="52563" checksum="61883B4788260D15" modified="2016-07-06" version="1">MTGFMASHVDDEMLFCETHYARYGNERTNIYGLAPFESRFLTYLNRPDEFPSHRYESLPSEPSPPKHQASAAELTAFVSMDGYWNYVCIPVGLEAGKSEVIAMDVFEEHSDKSRFVVALAVAEKYDTENQETQVSYSLRFYGHQHAPKSFLEQTLFGLGESSQIIPLTYPPMQLSHVQINYEGRQQTAFLMASTDGIMHLYVQDSSRLFVPISAGTYFPLLGRISDHRIKILFLHILTYQGKIAICAGGQNGELFLSFYDNEGVECKSHAIRLFSPITSVLLFHPRVSKHLKEDEPLHLVVTCAIEQAMVYKSVQINGLSRSRVLPQSSLYDSVLCSHVMDVDWDGEQEILIGTYGRQVLIYKQLEGTEDYTVLWRRQFAYPIYRMSHLDLNIDGLDELIVITMYGVHIFQPNMKKARKRLLDVLMYVESSKRQKYELLLDWQRQKELEKAIVFEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PHS6</accession>
    <name>A0A167PHS6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_141804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295984.1">
        <property type="nucleotide sequence ID" value="XM_018430674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PHS6"/>
    <dbReference type="STRING" id="763407.A0A167PHS6"/>
    <dbReference type="GeneID" id="28991580"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141804"/>
    <dbReference type="InParanoid" id="A0A167PHS6"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD77944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="270" mass="31344" checksum="0B6DD4B023CEA415" modified="2016-07-06" version="1">MEECIIESNVFENPAEYRYQLILGRTSILRTKLRDRFGCIKNNAVSLYPNLIRGKLDYEGILRHGICNMSALQPHFRTKRRKEKLFRVLKAYSLYDKRVGCCPNLKYIAGSLLTRMNEAQAFRLLTILLSSRSDMMDFRSLFFPSTDGYSPFLEYFDFLMAAKLPNMYNYMLSGDIRPSVYISHGFKSLFGLQGPAYLIENTIDLLLIEGPWILPYCMLALLESNEDTIMKMNHDEIPGFLWKDVFKPFESESSTFISSTLRLADIYVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PJ16</accession>
    <name>A0A167PJ16_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">No apical meristem-associated C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_141907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD78046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296086.1">
        <property type="nucleotide sequence ID" value="XM_018430695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PJ16"/>
    <dbReference type="GeneID" id="28991601"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141907"/>
    <dbReference type="InParanoid" id="A0A167PJ16"/>
    <dbReference type="OrthoDB" id="2507178at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45125">
        <property type="entry name" value="F21J9.4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45125:SF3">
        <property type="entry name" value="NO-APICAL-MERISTEM-ASSOCIATED CARBOXY-TERMINAL DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="26922" checksum="CB0207E446488007" modified="2016-07-06" version="1">MSNLPNIINLEADTSGKNVEQKGDAFWEKITNHYHEYAPEGGILHNERSLPACWQIINKGVNKYVGILLAIVCSNSSGTNDEWNKTKTKFNLYHYFRILARHLKWKPSAPTKKKRRNSKVAASAPNPIGEGIDEEEFPACPAGRKFVKEQEATKRKWEKNIERLIALHSESIAKGDKAQDIKILLIDTSLIADSVSHQMMLDLKKKVQERGIGNTPISNDDSMSSNLFDISSKGDDCDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PWN2</accession>
    <name>A0A167PWN2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coth-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_77071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296709.1">
        <property type="nucleotide sequence ID" value="XM_018443220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PWN2"/>
    <dbReference type="STRING" id="763407.A0A167PWN2"/>
    <dbReference type="GeneID" id="29004126"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_77071"/>
    <dbReference type="InParanoid" id="A0A167PWN2"/>
    <dbReference type="OrthoDB" id="10267127at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050">
        <property type="entry name" value="INNER SPORE COAT PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050:SF1">
        <property type="entry name" value="INNER SPORE COAT PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007891329" description="Coth-domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="566" mass="63840" checksum="F47B7B36B5C09B5D" modified="2016-07-06" version="1">MRLSIIAFAVATVLSVANAKKQITYNVVSLEGGQQDMSVIVDNVSYPLVPSAEVPILYTGSAPVASHGYKYAIGTGRNSMKAESFTRKKTNETTPNETFGRSWNTRKVKTVKPIFPPLQAIDRLDSPLHIDGEIPTVYLSGIQSELDNMHINAMQDITIPINFTYISPRDVQVFPDIEFELSGRSSRWLPKVSYNLKLKKKSKNHLYSYRRLKLRSIANDDSYLRERIGYDIIGSVGLATTKYSYVRVVLNDKPLGLFGFIEAFQNPWLLNEFANGDEDYENGPLYQGKYLTAESMMAGVSSDLSYYGNNITKYELGQYDLKEDPAKGEPSFQPLMDFTKFVYDAPTNTSDAVEVWQKTFDTDSFLRSMALEILMGYSDGYITMTNNFYIYYETKSSRFIYMPSDIDMTLGSSFFKISDVASGNYSTYPSFYKRPLLNKILEVPGFKTQFEDLIFDITKKLFNLKKLGPRIDDQAEMIAEDVAWDKICPRAGRNLISDGSADESLNAMGPAGVDMPTAKDYYARIGQPVPFKVAIDGPTGHLSLPGLKEYIKLQSDNTLKFFKNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PXI4</accession>
    <name>A0A167PXI4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Secreted aspartyl protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_29684</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296757.1">
        <property type="nucleotide sequence ID" value="XM_018439953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PXI4"/>
    <dbReference type="FunCoup" id="A0A167PXI4">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167PXI4"/>
    <dbReference type="GeneID" id="29000859"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_29684"/>
    <dbReference type="InParanoid" id="A0A167PXI4"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF1">
        <property type="entry name" value="ASPARTYL PROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007891342" evidence="11">
        <location>
            <begin position="22"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="12">
        <location>
            <begin position="82"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="316"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD78717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="388" mass="41629" checksum="2A86051380E18CF6" modified="2016-07-06" version="1">MKLTASIATLLAVTLFTITDAASTSKAKPLHFNLDANPSYRRNATRSVLRARGKYASHLTGLTEFSRPGAVAMADYENDIEYYGNVKVGTPAQTLKLNFDTGSADLWFASTLCSNCGSKHKKFNPKKSKTYKKDSTKWSIGYGDGSSASGTMAYDTVNLGGISIKKQGIGLAQRESSAFVSDPVDGLLGLAFNSIITAENFKTPMDNMISQKLIKSPIFSVYLGKQAKKGGGEFLFGAYNSAHVGGKLTTVPVDKSQGFWDIKISKMTAGKSSIGSFRGIIDTGTTLLLFTDEMAAKVAKGYGAKDNGDGTYTINCDPKKLSPLVMTINGAKFQIPAADLVFDKIGNTCYAGFGYAGLDFAILGDVFIKNNYIIFNQKVPNVRIAPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QIU3</accession>
    <name>A0A167QIU3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_58807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297801.1">
        <property type="nucleotide sequence ID" value="XM_018440384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QIU3"/>
    <dbReference type="GeneID" id="29001290"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_58807"/>
    <dbReference type="InParanoid" id="A0A167QIU3"/>
    <dbReference type="OrthoDB" id="2261102at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="101" mass="11195" checksum="E7BB5B805BC77FC2" modified="2016-07-06" version="1">MFSRIITSIRDQISKPHPDTTKGPSAQQKNSDVEDENGVHLTRSHSLQPTALEARRPSVTEAIGIQNVDSRGRRRSSTVFGISKVSVDDFMQKDLVSSSWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QJT3</accession>
    <name>A0A167QJT3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn(2)-C6 fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_139827</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297848.1">
        <property type="nucleotide sequence ID" value="XM_018430287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QJT3"/>
    <dbReference type="STRING" id="763407.A0A167QJT3"/>
    <dbReference type="GeneID" id="28991193"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139827"/>
    <dbReference type="InParanoid" id="A0A167QJT3"/>
    <dbReference type="OrthoDB" id="3362851at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="196"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD79808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="253" mass="27831" checksum="B803FFFEB9069A6C" modified="2016-07-06" version="1">MASKQDLQLESTRRNKRLKVVSACGECRRKKIKCNGEKPCTSCAKTNMECDYSRSLKPKPPTGTPLLERKKSVSPSTSTTGTTPIHAIESRLTMIEDVLRALLASSSTSPSLSLSEKDTPLSPSMSENSDPSADRTLPTFGSRERDPASHKYLHSGPPSCSTVYNTRPVHPTRDKRQRHECDLSYTHFAQDDHFVRLPPLHRPQPPLSASSSSSSSSSFFPSPKLSAIRTLLNDTDQKQQLPSVNAPPLASLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QL43</accession>
    <name>A0A167QL43_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_139880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297907.1">
        <property type="nucleotide sequence ID" value="XM_018430296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QL43"/>
    <dbReference type="GeneID" id="28991202"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139880"/>
    <dbReference type="InParanoid" id="A0A167QL43"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007891588" evidence="2">
        <location>
            <begin position="22"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD79867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="558" mass="62557" checksum="C0F009B41747CA03" modified="2016-07-06" version="1">MPERSGLGMISLLIMITGAASSDTPGDLESTALRNRFSGLEDQIHSLMAEFGVIEMLVKHPPATPVIQNASLQSWSIQCNPQGLSIETHMIAVESIYSALIRFALDNAIPSIPPSIRTHGQQPRWLVRNKTIFPTVKLGHFTSLLPSPQSTENVELDGLLPPLLPLSIVKSLLELYSTCLLHGGLQPFQKLYMNRLMEFNPETMPAADQFLYASIICQMVTHAYTWHPKVFTSMPMTKAGSRRLASQYYAYAKHLLSTLYFEPPTLVACHAACNLVLYHLESGQTAVLYIYSGIAVRMAAALQLYSPKGIERAAKAEAGNLPVVEVEEYGRSVLWLLYFLDTAASHLHSRPYEVRPDEPEISSILSQGPFPFNGDAHQHLFQWLEYQACAITRTIRKTCFDSSVEQIPYDAIADIEHRLTAFGVSLPPLEATDSVWNLRCQYVHRIKYQGLWILLHQTYLPAPISDKRCTDAALAIVDLFEAWLPHIDCYFRPCVHELRQASDILLYHVEGPLKTIALDGLEKLVKVVLQTPVHAIARTRPFVQRLQQVLALHGRTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QT76</accession>
    <name>A0A167QT76_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_163260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298277.1">
        <property type="nucleotide sequence ID" value="XM_018434764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QT76"/>
    <dbReference type="STRING" id="763407.A0A167QT76"/>
    <dbReference type="GeneID" id="28995670"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_163260"/>
    <dbReference type="InParanoid" id="A0A167QT76"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053043">
        <property type="entry name" value="Ras-cAMP_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014:SF1">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD80237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="301" mass="34051" checksum="5C5C0D8489423597" modified="2016-07-06" version="1">MVRTLELPMLSLAMPNIHKLDSITTDSLSCMWTVFSKCKENLENGRRLENLSWRLWYRESVVANDRPCSVNEPTTPIDEQEFALPSPASTVGPSIPIDPKPLKHVSPTSFKRMLTYLGSPTHQTQPQPPTTFLPLSLTPPTNCISSAPIIKPTSLPSRPTQRNSKFFILSNEDSEDEDSFEAEKSDADIDEDNEDVWQDDDECVTVSDDCESAYQREFKKQIVRSDRPSCPSLLSRLLVSQCTTTRPIRITATLVKPSDSTSNSISDSLRDCIDWEHRQNNFNAILNSPSTTSYSESFQWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QU79</accession>
    <name>A0A167QU79_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_137829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298321.1">
        <property type="nucleotide sequence ID" value="XM_018429882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QU79"/>
    <dbReference type="STRING" id="763407.A0A167QU79"/>
    <dbReference type="GeneID" id="28990788"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_137829"/>
    <dbReference type="InParanoid" id="A0A167QU79"/>
    <dbReference type="OrthoDB" id="2207231at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="186" mass="20224" checksum="069413AD57E11C68" modified="2016-07-06" version="1">MGVSVLISPSCPYPVTQIPMSSNYALAIKIGSLRIVCLYLPPSMSTHDALAVLSSIPLTNDTIICGDFNSRLGSLTGDYATNTRGLALCQWLEEHALTVVNGQLSPCTPTFISFHQNVEISSIIDLFITNMSFTNATLNIHTDLSLNSDHRLLSLSFIYAINPTSHAPPPSPLEKRTGITMYKVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QZY8</accession>
    <name>A0A167QZY8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_138093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298571.1">
        <property type="nucleotide sequence ID" value="XM_018429934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QZY8"/>
    <dbReference type="STRING" id="763407.A0A167QZY8"/>
    <dbReference type="GeneID" id="28990840"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138093"/>
    <dbReference type="InParanoid" id="A0A167QZY8"/>
    <dbReference type="OrthoDB" id="2239391at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="143" mass="16346" checksum="D86E8ADA0787DEDA" modified="2016-07-06" version="1">MVRAHLDQRLFPVHTFQILLQRRPYFQASTLFINSLQTNKPLTARTIQIWISKLIRLSTSEPRVSLRSIASSLALQSDIPKADIVTMGHLTWSTTFEKHCLREHLPRFDFTNKLITSGDDDSEDDSNVEDVLFDAVDSPMDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R7Q3</accession>
    <name>A0A167R7Q3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_138591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299087.1">
        <property type="nucleotide sequence ID" value="XM_018430027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R7Q3"/>
    <dbReference type="GeneID" id="28990933"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138591"/>
    <dbReference type="InParanoid" id="A0A167R7Q3"/>
    <dbReference type="OrthoDB" id="5514950at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="34458" checksum="01BC027BA4F4B3EA" modified="2016-07-06" version="1">MRALQSLGVNHTGLSRLLSIRLYRQFIRPQFEYGLAISCFNIKQVAVLEKAQNTCLRMIFGGHSTSSTSVFRHLENLPSMRERILTLGFKFVYHAFWLSDEALFTLLRPVLTNPAHQWFKLLANPIWLSLSNHQNADSKACKHAIRSFLNQGLFLQRSQQILLSACRSSLGVDPILWLPMTNYERSRFIRWRMGWLPGRPQPCSCGLHTTSHHHVIECTGAAIRLHLYSTVQPNPIDYVLNMLPLKKLKNNKNNAFWIFTWPILCRIMLDIEQICLPGVDLADHAATDRGQLFLNWLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167RDT6</accession>
    <name>A0A167RDT6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_120933</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299467.1">
        <property type="nucleotide sequence ID" value="XM_018428769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167RDT6"/>
    <dbReference type="STRING" id="763407.A0A167RDT6"/>
    <dbReference type="GeneID" id="28989675"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_120933"/>
    <dbReference type="InParanoid" id="A0A167RDT6"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01871">
        <property type="entry name" value="Rac1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000088">
        <property type="entry name" value="Ras-related C3 botulinum toxin substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD81427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="192" mass="21485" checksum="544F488893010492" modified="2016-07-06" version="1">MQSIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPINLGLWDTAGQEDYDRLRPLSYPQTDVFLCCFSLVSPPSFENIKTKWFPEISHHAPRIPKILVGTKLDLREDQDTIGRLKEKRMSPISYTQGLQMAKEIGAVKYLECSALTQTGLKNVFDEAIRAVLSPTVHRKRKNNCLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N838</accession>
    <name>A0A162N838_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_174966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441001">
        <property type="protein sequence ID" value="OAD66674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284714.1">
        <property type="nucleotide sequence ID" value="XM_018437380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N838"/>
    <dbReference type="STRING" id="763407.A0A162N838"/>
    <dbReference type="GeneID" id="28998286"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174966"/>
    <dbReference type="InParanoid" id="A0A162N838"/>
    <dbReference type="OrthoDB" id="2287601at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="26214" checksum="039E83208FECB12E" modified="2016-07-06" version="1">MIIDFERAAGTKVAEMEEAVKTITVQMEEHQLYQLVFLESFLKSTRGSLLTLFDKRPTITLEVAREKLCRNLKGLEISIRGLHKHITREMLANLEERDKKIAFFIDEDGFQSQMTRCKGVAKKRNACYGQGAYTKGVNTSIIGCIASFDLFNFLKVDPIRKIDAEIIESEFHSKEENKGKKQKPNSQKEAKPKPKKGTTAYHIVKFTEATINMLERLDRRDYFIVTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NGL7</accession>
    <name>A0A162NGL7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_172669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287464.1">
        <property type="nucleotide sequence ID" value="XM_018436846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NGL7"/>
    <dbReference type="STRING" id="763407.A0A162NGL7"/>
    <dbReference type="GeneID" id="28997752"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172669"/>
    <dbReference type="InParanoid" id="A0A162NGL7"/>
    <dbReference type="OrthoDB" id="2289822at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="455" mass="52241" checksum="534338403C6EB1CF" modified="2016-07-06" version="1">MYFDDISARLRPLEDFKVGNPNIYQPSIYTQLSTFSESSFFALDKLHLIARGIRKLVYDLITVTLTKETKFYYTHLDNTLNTTKYPFHIPRADLVTIGNCITSSRKYIPTLFQGSFDNIFAKIDDTRAVDWLDFLLYLVPTLVVPYLPNRAVKTALLSLVKGCALALQWTLTSELLDEMESYFKHWHSFLYQQQQGPLRCYSTRSMERVIGVFSKLIKSKSKGGRNASFLVEQFAIHNYTSMAISICDEINLIWPKPYGRESYMDLPNDPSGAQLWEPFHQFVNLNDDLVEGVGGPSVKEALLKYYWRTTGLTGHEFGDSVVVVAARLWMDLTVYSSCIKCNIIVHSWLVSTVQFYFQHVDFYGFPHFFAFVEVMKEYDAAGHDSSVPIVKQKSQSTHTLGHQTQPTYAVISINDICHQAGLVQYPPNRNQFYVIVPYYIFNNNMHITKGNLSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PGM4</accession>
    <name>A0A162PGM4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Kynureninase</fullName>
            <ecNumber evidence="4 5">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Biosynthesis of nicotinic acid protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BNA5</name>
        <name evidence="6" type="ORF">PHYBLDRAFT_146812</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>L-kynurenine + H2O = anthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the kynureninase family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="4 5"/>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290667.1">
        <property type="nucleotide sequence ID" value="XM_018431729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PGM4"/>
    <dbReference type="STRING" id="763407.A0A162PGM4"/>
    <dbReference type="GeneID" id="28992635"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146812"/>
    <dbReference type="InParanoid" id="A0A162PGM4"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00329"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000031">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084:SF0">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22580">
        <property type="entry name" value="KYNU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4 5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="156"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD72627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="454" mass="51196" checksum="74E77C8D45AAF936" modified="2016-07-06" version="1">MSAKTNDLSPTSLEYAQLLDSQDTLARFRKEFNIPTRRDVLSPDLTADNEKELDLPCTYLCGNSLGLMPELARKRVIEELDVWSKRGVEGHWNHPHNRPWVTIDEIVKEPLARIVGAKPIEVTPMNTLTSNLHSMMITFYQPTKSRFKILIEEKAFPSDHYAVSSHIQSRGIDPEVGLLTVGPRPRESTLRTEDIIKTIRNDKSIALVLLSGVQYYTGQLFEIEKITKAGHEEGCMVGWDLAHAVGNVPLQLHDWQVDFACWCSYKYLNSGPGGIGGLFVHEKYANDTSRPRLAGWWGNDKENRFEMKPEFSPSKGAAGYQVSNPGVLVTSALAGSLEIFDQAGFTNLRNKSVRLTSFLETLLVTILATHLRAGHFKILTPTDVSQRGCQLSLDFPERMIEVFEELQKRGIICDERKPTVIRIAPTPLYNSFEDVHRVVYSLGLILDRIYPTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PKB4</accession>
    <name>A0A162PKB4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_149449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287706.1">
        <property type="nucleotide sequence ID" value="XM_018432277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PKB4"/>
    <dbReference type="GeneID" id="28993183"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149449"/>
    <dbReference type="InParanoid" id="A0A162PKB4"/>
    <dbReference type="OrthoDB" id="10571371at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007838219" evidence="1">
        <location>
            <begin position="20"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="148" mass="16833" checksum="33BC3A3B21554D07" modified="2016-07-06" version="1">MRIMYFSFFRLLIFLESDSTNWDQIELFHTSKKVTIYGPVESKRRPSQGNVAKAKNPEIKIAQLANKRKKLHWHLHLRADNEAVNSLLVGQPPTAATLQNDKIDNFFNSGPSFSVLPIKSDLNTLLCYNILDFVTTRQKAGTKSILGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PQS4</accession>
    <name>A0A162PQS4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_67899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293177.1">
        <property type="nucleotide sequence ID" value="XM_018441863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PQS4"/>
    <dbReference type="STRING" id="763407.A0A162PQS4"/>
    <dbReference type="GeneID" id="29002769"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_67899"/>
    <dbReference type="InParanoid" id="A0A162PQS4"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF2">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD75137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="799" mass="89708" checksum="EED4887FECA28FC0" modified="2016-07-06" version="1">MLFTSTTTQENDTLWSGHQPQSEGSLFRINSMVHTERGFQTPYSAHIELPEQPIKPLPKVPIESHLPQRHPMLFDSFVPRSDYGTLERRWNYIETPTMPLSPQQSSCYVGHYNPQATNTSLSQSNGLYNTLSPWNSIRHTTIIDTMPLQQPTLPAWVSCDLDRTESMKIEVPSSAEEYTSLPFEAQSQIQPIKLQKPFDPSVHPSSSAKPNEQEENQVEEDQETPRVKDITSGLTAISLDHSSNIHLPHTPDRENYKDRNVKVMRTSLNIPSSRSSMDVNSALGHSTPGTSVTSDHLIPDKFTPDQVGDEDDSDNFSQESSDEVIYERMHLQSDSVYENVPTSIKPRLSIRTTRPIDINQVHLTQPSNGNYNRTGPINPAQIGTSHHSPLTRIPPVHSLSADPARPRLTIGSISLVRSEESIKDFSRMAGKTKDPNTQMVYASYLLEIADLYQVPALSTSIRHALLKEACTWIERLAKSGIPEALLIQGRWYQLGHAAPDCVGRKYVKINTAKALKCYQQASNAGLKDASYALAAYWKSQNDWLKASSYYQSASQKGHILAKYANELARLTFDHRVENSNDVKTGLKLLLESARSEVKDSAAACFMLSCIYGRHFGLVGLTEDPEFGPFDPTNAYFYLSKAVRMGHLDAIHKMGEVWELGLWDKTSDIEKAIEYYTRAAQESHPGSMFELVKIYSGQIDYPSQPEQAILWCQRASDKGYAKADYLLGLYYEEGLNGLEIDYPRALGYFTKAASNGYTEAQARLNIPINMVPENTPHNNQGRFERAAKRLSSARINCDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PUA0</accession>
    <name>A0A162PUA0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_168454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD74046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292086.1">
        <property type="nucleotide sequence ID" value="XM_018435870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PUA0"/>
    <dbReference type="GeneID" id="28996776"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168454"/>
    <dbReference type="InParanoid" id="A0A162PUA0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="137" mass="15583" checksum="4958E1F1CB13B35B" modified="2016-07-06" version="1">MSCLNWDGLNDFQFAPLILSVSQDFSGPLTKTYTLGGFTKCHWSLSRSSFFDYTPTLILYRQTNNISIFRMLHLLLQCHCILCLSTLLFSELSDIHLFSCLTLFKQTGQEGVPQQAMEYSRGRLHQGWTNGCSKGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PWU5</accession>
    <name>A0A162PWU5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_185834</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294767.1">
        <property type="nucleotide sequence ID" value="XM_018439152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PWU5"/>
    <dbReference type="STRING" id="763407.A0A162PWU5"/>
    <dbReference type="GeneID" id="29000058"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_185834"/>
    <dbReference type="InParanoid" id="A0A162PWU5"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF82">
        <property type="entry name" value="THO COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="194"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="18"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="299"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD76727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="337" mass="37427" checksum="69FB624F530C4756" modified="2016-07-06" version="1">MKTIAVDLDTSLDEIIKTRKNRHSRDNNFYSKSSYKPAGSDNRRVEKHETYRKSQHPYSKPSRYNTSESSDNRRPTYSARPAKASPLQSSSSSSSNSHNSSSHNTSKPDPSRIVITKSVTRRLPMDLMINQDAKLDDGSEMGRIRKQPPLSHEIRLGAPQQPLYQHQPTNYAIRGLSQQSPVRGLSIRGESGPAVVLISNLDPGANAEDVKTVCAYFGHILQCKILLDRSGRSYGEAEIEFAHKSSALDCVAKMDNGIADGRVLRVMLRNRMTPTAPLMPPPIPNQNNTRSVITPTRSGYTSGAKPYSDHNIPVGPASNELPDYSRYQSFTGGNRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PZ81</accession>
    <name>A0A162PZ81_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_143924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018431101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PZ81"/>
    <dbReference type="STRING" id="763407.A0A162PZ81"/>
    <dbReference type="GeneID" id="28992007"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143924"/>
    <dbReference type="InParanoid" id="A0A162PZ81"/>
    <dbReference type="OrthoDB" id="2596771at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47456">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="54627" checksum="224A40EFE8A5734B" modified="2016-07-06" version="1">MSISNTQSNETIYTLATISQVLECSSVPEVMTLRLENIIRVKTSEWKECLTEIGKACAVKWVICNTNKQPTNITAEEAKATDYAEHTPGDMRSDICTLPLAKKYLHELAQQLKQSSKSASQIRIDMLRAINKKLYHFDKDQMTSFLIWMNNKLSALNFNIFKANTSYSLDPSAFAYGFMSPIQQEKMKTATSFCLDVTHAISSNVNEILYTLLMRDEDIGRVWPVAFIVTNDRGVSPIVQCLQFLKRSSLLVDPKQFTIDCCAAEVHAIQTTFLATSIQFCIFHETQAWNQKLSDSVKTPGSLPSEARILRGVMIKSLQEIIYEEDIDEFHHKIRNWCTEAKFKIWSRAYHEQQFSHMLTNNYIKSWHNQLKTVFMKRSRNKRLDKLVFVLLHDVEYYLTQEYERVMSNNDPMSSFTRQQRIHEMGAEEVNDDDREMMIVAPGTAEDVAEPNLIISCICFDYQRRYKPSSLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PZC0</accession>
    <name>A0A162PZC0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_164313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295437.1">
        <property type="nucleotide sequence ID" value="XM_018434986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PZC0"/>
    <dbReference type="GeneID" id="28995892"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164313"/>
    <dbReference type="InParanoid" id="A0A162PZC0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="161" mass="18984" checksum="4934ABBA73E9D4A4" modified="2016-07-06" version="1">MKYDCKILLKQYQIFDSWGRLKKTGRIQLVESKCSRILVYVQYYRKSGTLAIGPNCEKSIEIQLIQSKDPKRPVYLRLWMKIKALISCTDSENVNETLIVHLCSEKYRKIQKIQMRITYLIVSQDGKDTRHIQVTVSESIKNVFISVTLGADWILDCWFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PZR6</accession>
    <name>A0A162PZR6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWR1-complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_185527</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295557.1">
        <property type="nucleotide sequence ID" value="XM_018439087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PZR6"/>
    <dbReference type="FunCoup" id="A0A162PZR6">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162PZR6"/>
    <dbReference type="GeneID" id="28999993"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_185527"/>
    <dbReference type="InParanoid" id="A0A162PZR6"/>
    <dbReference type="OrthoDB" id="445677at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011421">
        <property type="entry name" value="BCNT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407:SF1">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07572">
        <property type="entry name" value="BCNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51279">
        <property type="entry name" value="BCNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCNT-C" evidence="3">
        <location>
            <begin position="81"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD77517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="161" mass="18206" checksum="F3CA11916CA22305" modified="2016-07-06" version="1">MDSSEQKAKIDAIWAEMNVPKTLAAKEPIKTNILTNTNANNTNSNTITNSTTKGISDPPSILDAPTLKSLPLGRKKKSGLVRPKSKLSDLVTQYNVKVPKMNTLEKSRLDWQGYVDREGIRADLKYQNKDGYMEKVAFLQRVEDRRFTHLKTGQRESKNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q438</accession>
    <name>A0A162Q438_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_58919</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297916.1">
        <property type="nucleotide sequence ID" value="XM_018440404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q438"/>
    <dbReference type="STRING" id="763407.A0A162Q438"/>
    <dbReference type="GeneID" id="29001310"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_58919"/>
    <dbReference type="InParanoid" id="A0A162Q438"/>
    <dbReference type="OrthoDB" id="2264563at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046868">
        <property type="entry name" value="BAR_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046869">
        <property type="entry name" value="SLM1/RGC1-like_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941:SF1">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20400">
        <property type="entry name" value="BAR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20399">
        <property type="entry name" value="PH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="599"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="736"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="753"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD79876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="973" mass="108780" checksum="AF138D43B95FABCA" modified="2016-07-06" version="1">MATSTSPPPRPEKSKFRNIPSSSSRNLPPPLNIDYDPKEPNKSLVERLESPIYPLYTPVHLSSSRHESVVSLSIPEKESNQFEINIDEIRHSGRFKEEFDQIPTPELLEQLLKSSSIKPLKRPWLPKKRSKSRSHVIQTSSSTSTVDTAGSFGPPFPGTPILESPQTPTPTTSFQKNTSSYFPLFSTAPAALIAGRKTSLSNEISLTASTSKPETLAVLVDTTSQAVSDNVEGNVEDKLKRSLSVTAAPVTSIPTKHTPLPISSAHKIKQIQQTESKVHKDILPKSDSNPGTPETAVPVPPVRRPTYTNATEKSNGNTSRPAEEFSLNRADVVITRLENWLFIIKAIGAWLEETARINVQSSRSFQQQSLSLLKEDYMGQKEPTNAIATLYTGLKMLTVTVIQEQRDFSEHVFQDHIPAIMKLKKECKEKIRELGENQDLAMDELLKRAEVTVKTMSHLDRCCRGMDRETGDDQRLQQLQDPWVANLYVLRQLKKEVDEENRLRILMVGVQKDVAAFERRVIQSLKTSIQFCYENIPPGLSDDSSEDRTPFKALLDMSTPEVEWEQFMEDHKKDLVNEQFPTKDYRNINFKNKHNPYVLTLMKGKIERKTGVRKQFVEKYFVLSQCGFLHQFSLSDKVAPERFIYIPNSVIVPSIDINQFVNESNISNEMTNDESNQHYTFEIRRPSTTVLQRDKTYQFRVSSRQALLDWCKALVEVAGRSYMAQYLVSNRSSIGLNRDSSSISAEDKPPSETDMTTKSTEVLNPSSSDMEAKAGSNNNNDSTLSFVSEVQSGSTECSSKLDESTTQNTRPLETIESETGSLGKLDKDNSRSSDIKLIDDHGNVSDQALVNVLEEGGTNDVIQEYYASHDSGDEDDDADSISSRSICTARQSLSTIADLPELIDIAREPSQVSDPRRYSGESNLIDDAASSLYFSSTSGPNSPSGSTFSIDSYPEIDIAAYSLPALEAQNRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T351</accession>
    <name>A0A162T351_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_175644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441007">
        <property type="protein sequence ID" value="OAD65902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283942.1">
        <property type="nucleotide sequence ID" value="XM_018437536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T351"/>
    <dbReference type="GeneID" id="28998442"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175644"/>
    <dbReference type="InParanoid" id="A0A162T351"/>
    <dbReference type="OrthoDB" id="2404656at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="173" mass="19697" checksum="30F13A57D29B840E" modified="2016-07-06" version="1">MDEWFHEDNPRSVDGLGYDRNGVERVFFFLKKKKGSSGEGRVVVDKTVYGGRKQPSSLMSMLKGIANPYLNVNFDILLLTKVFGIQSVKTNIISNIILSELKLQDNGVSFTKEVRSAEIPKMYAQGHKWLKGFEFWGTHCGEIIETSSTYETYGIFHIHVRSQCNSSLNTHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162THY7</accession>
    <name>A0A162THY7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cas12f1-like TNB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_63697</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285343.1">
        <property type="nucleotide sequence ID" value="XM_018441158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162THY7"/>
    <dbReference type="GeneID" id="29002064"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63697"/>
    <dbReference type="InParanoid" id="A0A162THY7"/>
    <dbReference type="OrthoDB" id="2227456at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Cas12f1-like_TNB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="Cas12f1-like_TNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Cas12f1-like TNB" evidence="3">
        <location>
            <begin position="250"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD67303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="340" mass="38404" checksum="6907598F91141494" modified="2016-07-06" version="1">MSYPARKRCPYKFSARNAFDKKVLLDKSFTGGILTEDIALESIFERPAPAGIATKIDLSTTILWRLDPGVRDAIVACVGAGAGAGQNRQSHIIRKTSTGEYYQLSGFKSATIKRARNDRVNVDERRLISNTLSTRTCNWDQFNEALRYTFWSFEATKGCYSTSLRNLRYHSYRNKQKTLDEMCKRLFTGSINLYLLGSILARSKDLLWVAFGAARFGGLGGNTAPPTKSFRAALLNYIKPTGRTQAHISKYVVMIEEYLTSQICPRCPTESISNQLDDLDVNIHSVPNCESCNTRCNRDHIAILNMRYVLLYMCLAGFLSTYITVQDTQYTHRISTVNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TIA2</accession>
    <name>A0A162TIA2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aspartate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="4">1.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHYBLDRAFT_137006</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the NADPH-dependent formation of L-aspartate 4-semialdehyde (L-ASA) by the reductive dephosphorylation of 4-phospho-L-aspartate. Mediates the second step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-aspartate 4-semialdehyde + phosphate + NADP(+) = 4-phospho-L-aspartate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:24286"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="4"/>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285413.1">
        <property type="nucleotide sequence ID" value="XM_018429826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TIA2"/>
    <dbReference type="FunCoup" id="A0A162TIA2">
        <property type="interactions" value="312"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TIA2"/>
    <dbReference type="GeneID" id="28990732"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_137006"/>
    <dbReference type="InParanoid" id="A0A162TIA2"/>
    <dbReference type="OrthoDB" id="1894490at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18130">
        <property type="entry name" value="ASADH_C_arch_fung_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02315">
        <property type="entry name" value="ScASADH_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000200">
        <property type="entry name" value="Aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000016">
        <property type="entry name" value="Probable aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051823">
        <property type="entry name" value="ASADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006416">
        <property type="entry name" value="PRK08664.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718:SF1">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000148">
        <property type="entry name" value="ASA_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="14">
        <location>
            <begin position="6"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="13">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000148-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAD67373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="358" mass="38470" checksum="C7A1DE0854434949" modified="2016-07-06" version="1">MSPSKKVGILGATGTVGQRFILLLADHPVFTIHALGASSRSAGKAYKDAVKWKQSRAIPANVKDMTVKACVAEEFKDCDVVFSGLDADFAGEIEMAFLKADLAVFSNAKNYRREPTVPLIVPTVNTSHFDLIPQQRALHNLKKGFIITNANCSTTGLVVPLKALQDAFGPMSHILVHTQQAISGAGYPGVPSLDIFDNVVPHIGGEEEKMEFEASKILGGVTADGKEFAPLNNMTVSATCTRVPVLDGHLESVSVKFVNQPPPSVEAVYEALDKYTCEAQKLKCHLAPEHAIVITKESDRPQPRLDRDNEKGQAVTVGRVRKCPVLDLKFVLLVHNTVLGAAGSSVLNAEVAVSRGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TL05</accession>
    <name>A0A162TL05_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Carnitine O-acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="16">2.3.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PHYBLDRAFT_178119</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-carnitine + acetyl-CoA = O-acetyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:21136"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57589"/>
            <dbReference type="EC" id="2.3.1.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.7" evidence="16"/>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287452.1">
        <property type="nucleotide sequence ID" value="XM_018437956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TL05"/>
    <dbReference type="STRING" id="763407.A0A162TL05"/>
    <dbReference type="GeneID" id="28998862"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_178119"/>
    <dbReference type="InParanoid" id="A0A162TL05"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000007">
        <property type="entry name" value="Carnitine O-acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF103">
        <property type="entry name" value="CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 19" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="21">
        <location>
            <begin position="57"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OAD69412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="642" mass="71958" checksum="0E49C3B89CFE8F1F" modified="2016-07-06" version="1">MSVRALTSMTRMTSRVSLSPAATNTTRRVATKMAPKTPIDATAAGPMLRYQKNLPKLPVPALHNTLQKYLQSVRPLLSDEDFQKTQKAVSEFEAPGGIGEKLQERLLAKANNPKVVNWMEDWWLDQAYMGYRDPVVIYVSYFFLYKDDKLRKAPANRAAAITTAALEFKKMVVEKTLEPEYAKGEPMCMDSYKYMFNNCRIPKKPSDFEAQFDPISNTHVVVVRKNKFFVVDTVHNGQQLSTQELQSQYERVIDAAGEAKGLPLGVLTAENRDTWTDYREMLLAADPANKDILHKIESSSFVVCLDDYSPVTRDEGSRACWHGDGRNRFFDKPLQFIVFENGKAGFTGEHSCMDGTATCRLNEYVTDGLSRNKINHGVTARTSLPAPVELSFKVNGQIEDAVKSAEKNFDSLISKHDLTVLAYNAFGKNQIKKFKSSPDGFAQMVIQLAYYKMFGVNRPTYESGQTRKFQRGRTETCRSVSTESIRFCKLMEDPTAPTEAKIGAYRAALKSQGSYMADAVNAHGVDRHLFGLKNSLKAEEPKPALFTDPANAYSSHWYLSTSQLSSELFDGYGWGQVVNDGFGVAYMIKANSLQFNVASVKDLEVHGKKYVNGTHQFKQCLEDAADELRDILLTETPAEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TMD4</accession>
    <name>A0A162TMD4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_102318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286333.1">
        <property type="nucleotide sequence ID" value="XM_018427708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TMD4"/>
    <dbReference type="STRING" id="763407.A0A162TMD4"/>
    <dbReference type="GeneID" id="28988614"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_102318"/>
    <dbReference type="InParanoid" id="A0A162TMD4"/>
    <dbReference type="OrthoDB" id="2439011at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="176" mass="19726" checksum="FF1E88F94D49BD1F" modified="2016-07-06" version="1" fragment="single">NLPREERMKLENIILVGVMPGPKEAKIDQMNNFLEPLVDELVELYGSITVKTAAFPNGTIVRATLMYVACNITAARKTAGFTGHASTNACHKCEHHFSVIAGSSKIDYSGFDNESWVPRTKEMNAIYADMWACAESNAERADLEKQNGTQFSDLHCLYYFDPVRCTIVDLMHNLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TUX4</accession>
    <name>A0A162TUX4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar ATPase assembly integral membrane protein VMA21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_94991</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD70023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288063.1">
        <property type="nucleotide sequence ID" value="XM_018443875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TUX4"/>
    <dbReference type="FunCoup" id="A0A162TUX4">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TUX4"/>
    <dbReference type="GeneID" id="29004780"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_94991"/>
    <dbReference type="InParanoid" id="A0A162TUX4"/>
    <dbReference type="OrthoDB" id="160405at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03058">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019013">
        <property type="entry name" value="Vma21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792:SF3">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09446">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD70023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8306" checksum="968EE3D56EFFF793" modified="2016-07-06" version="1" fragment="single">QQTNGRPSVSAVVMTKLIGFSLAMFILPIMTFYTTVDRIFGGNTTYAAGSAAVVANVVLIGYIIVAFMEDPDKDKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TVY3</accession>
    <name>A0A162TVY3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Secreted aspartyl protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_70807</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289452.1">
        <property type="nucleotide sequence ID" value="XM_018442336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TVY3"/>
    <dbReference type="STRING" id="763407.A0A162TVY3"/>
    <dbReference type="GeneID" id="29003242"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70807"/>
    <dbReference type="InParanoid" id="A0A162TVY3"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007840105" evidence="10">
        <location>
            <begin position="17"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="11">
        <location>
            <begin position="65"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD71412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="460" mass="49361" checksum="D2FE0971CD0AB69B" modified="2016-07-06" version="1">MLLLLGISALINTASTAKSVPGIVRMPIFKRSQSTSIITKRRKRDILKEPGLFKSGLYNDYGSQYLVHLSVGTPPQKFTVTLDTGSANLWVPSVKCNPELCPHTRFDQKKSSSFNDTGKSFDLQYGIGNATGVYGTDTVSIAGATIQNQQFGLATSTHNLLTDVVSFDEDSPPAEPSQGSLAISDKVENGILGTGFPQLTVPGLGSQKPHYPLVFNMVRQNIIKDPIFSIYLGAATDMGWAGEIVFGGIDSTKHSGDLVYLPVTPYDTTSREISLDPSSGKTVDDYFYWQVYSQGISATNGNSTTKFDVSPDKGYIFDTGSTLSYFPQSIVEPMLTGLVGPSGYSYDPSTSSYFINCHGMPPNATVQLQMSSTGSKMTSPTTLTILASKLVIPVNGATVEDATKCIFGIGENTFLANENMSSMYLIGDTILRTTYLVFDMGKKRIGIAAAIGSGSVVSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TYZ3</accession>
    <name>A0A162TYZ3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_148173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288993.1">
        <property type="nucleotide sequence ID" value="XM_018432027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TYZ3"/>
    <dbReference type="GeneID" id="28992933"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148173"/>
    <dbReference type="InParanoid" id="A0A162TYZ3"/>
    <dbReference type="OrthoDB" id="2273311at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="29808" checksum="1340CD0A2F171E38" modified="2016-07-06" version="1">MKTGWKRLNVSDAFIFDQDLQAIRSRTQTERSRIFFWHATLPPNDHPELLLPVNPLIVDCKPFVGALQTGCKRLSDFTTNRFREACQDHTQSPLVPLPLQAKQWRLFWAFPIHHTSQNIWYWAILNSLSCQYTLHSRAPTIFVTPNCPICLSEVGTLSHFLYQCPQKWTVWETAWIKYFGLSPSTFDIHRALFSLEIPDHPSPVFHVHPCQITSSIILALWRTQWSFIFDNRTFQTSSINSKIDALVSHLSSDLNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U079</accession>
    <name>A0A162U079_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_187385</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cclA family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290472.1">
        <property type="nucleotide sequence ID" value="XM_018439376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U079"/>
    <dbReference type="FunCoup" id="A0A162U079">
        <property type="interactions" value="453"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162U079"/>
    <dbReference type="GeneID" id="29000282"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_187385"/>
    <dbReference type="InParanoid" id="A0A162U079"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12872">
        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049455">
        <property type="entry name" value="ASH2-like_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053835">
        <property type="entry name" value="ASH2L-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21198">
        <property type="entry name" value="ASH2L-like_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21257">
        <property type="entry name" value="PHD_ash2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="10">
        <location>
            <begin position="324"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="230"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="230"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD72432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="671" mass="76090" checksum="EE3119394204B707" modified="2016-07-06" version="1">MTTLTWNETHTLNVQHKYCYCGQDRNLLEICLQCKFCRNWFHSKCTQVSNPPDLLFTTNYSFTCLNCNSENNQKEIFERTTAGWKDICSTTIANLILEDILAHVGTDRPELFDSKHSRLMAQWYPEQYYFNKKEIIPYVDKHWDSICTERIRTPTWWATLGSCLYSSKETFVARDERQRSAASDFCLADANLWHIRPIQAATKPVQIPRMTKQRMRSDSDQRAIASTASTLLHQSTSSSSSASLAITSPPSQSSQSQSQSLQLPSSPALRSGRDGSNVKWRSATPTPSPGSASPVLGVKTVPTVFSSTSTDHPCNRFGFKYMPCEQSCLPLVAYQQADNVLGGCTISIADKSSYVSVAKDGLTVTTDRGFRMCRANVGVKEGNWYWEAVIQRANGSSGAQGPHVRVGWARREACLNGPVGYDAYGYGYRDLTGDKLFCSRPSPYGEPFATGDVIGLYISLPPRTHFKSPARKRIPIAYKDHLWFEEKDFRQSKEYEAMADPFRSTDKPLDPPPRTIPKSHITVYKNGVCQGVMFEDLFDFEDFGSLPDIIMARRNKRRKKQKKETVNGIRMRMEEDEFDGVRAQQWTEDPPLEDDGTLGYYPAVSVFQGGMVTCNFGPDFQYPPSPTTTKGELWKPMSQRYDEYMAEECVWDLLDEVSRSSRKKETPRQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U7N1</accession>
    <name>A0A162U7N1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_134155</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD73043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291083.1">
        <property type="nucleotide sequence ID" value="XM_018429624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U7N1"/>
    <dbReference type="SMR" id="A0A162U7N1"/>
    <dbReference type="FunCoup" id="A0A162U7N1">
        <property type="interactions" value="429"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162U7N1"/>
    <dbReference type="GeneID" id="28990530"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_134155"/>
    <dbReference type="InParanoid" id="A0A162U7N1"/>
    <dbReference type="OrthoDB" id="498286at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000002">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="11">
        <location>
            <begin position="44"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD73043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="103" mass="11393" checksum="DF28C91A24279C5C" modified="2016-07-06" version="1">MTGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTSLDVVYALKRQGRTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UA44</accession>
    <name>A0A162UA44_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_167051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292742.1">
        <property type="nucleotide sequence ID" value="XM_018435558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UA44"/>
    <dbReference type="STRING" id="763407.A0A162UA44"/>
    <dbReference type="GeneID" id="28996464"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167051"/>
    <dbReference type="InParanoid" id="A0A162UA44"/>
    <dbReference type="OrthoDB" id="2499658at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="161"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="490" mass="55064" checksum="C77E10A3B7355864" modified="2016-07-06" version="1">MNTVYKPVTLDRMASQSIYDYATDSQRLSNNHPNQPFSHGPELPFAVEATQSQNNQCEHLSVMSTPSCSNDDQYPSYAEIEVIIQEYLDNLSSKKRDKALIDRDRYMLILQVLKRPKNTAISTAQFRFWVKKMFRLVSCGGNSYIYHDDKPVATREDIYGILLCAHNESRHGGRDKTSVLVRQRYSWIPKELIARFVRSCPVCILKRNGSQSPTLGFPRTPSDTCEPVQTMDGFVQMETHNAFSKYFRRDHPAIADEEWHRQNFGHNYQHYNQHLNNHNIHNNNSDNNNNNICLYHAPTHPVIDGSLGMSTSVPAATVTASSEQFAFGPLAPDSFDSSLYGHTCSESNHLPSTFGPFCNTCQPAPSDVGYTAEIMNASCSANTLTASHNYPRQPSSVSSLSCSPSTTSSEYIMQSTPSVPYAECAPNCITASLPLDRILVDHIMSPSEVSNLLSDQNPEESFGPYYARPMSSFVHMNTMPFDVKQNPNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UFP7</accession>
    <name>A0A162UFP7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH dehydrogenase [ubiquinone] iron-sulfur protein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-15 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase 15 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHYBLDRAFT_132057</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFS5 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293922.1">
        <property type="nucleotide sequence ID" value="XM_018429462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UFP7"/>
    <dbReference type="STRING" id="763407.A0A162UFP7"/>
    <dbReference type="GeneID" id="28990368"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_132057"/>
    <dbReference type="InParanoid" id="A0A162UFP7"/>
    <dbReference type="OrthoDB" id="9992197at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24141">
        <property type="entry name" value="NDUFS5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019342">
        <property type="entry name" value="NADH_UbQ_OxRdtase_FeS-su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR619342-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAD75882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="101" mass="11545" checksum="91C55C3BC56FAB83" modified="2016-07-06" version="1">MASGFGYDGSRGRCFQFWQEFNKCYANADFPQQCISQRDDYLECLHHTKEFARATRIKTEELKQAEKRLQAKKASSAAADSNLPRLNIINDNVQKPVEAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UI88</accession>
    <name>A0A162UI88_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_19913</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293453.1">
        <property type="nucleotide sequence ID" value="XM_018439713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UI88"/>
    <dbReference type="FunCoup" id="A0A162UI88">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UI88"/>
    <dbReference type="GeneID" id="29000619"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_19913"/>
    <dbReference type="InParanoid" id="A0A162UI88"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="505"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD75413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="763" mass="83843" checksum="C0531878F1636B49" modified="2016-07-06" version="1">MAEPILLEYEPLSHRQEATKIVRKIPNATKTYVAGLFPIVQWIHRYNLTWLVSDLIAGITVGIVVVPQGMGYAKIANLPPQYGLYSSFVGLCIYCFFGTSKDISIGPTAVMSLLVGQAVAHVTEVSDYTGPQVAVTLALISGVISIFIGLVRLGILVDFIPGPAIAGFMTGSAITITIGQWPNLFGLQGVDTHDAAYLIFGNFFKRLPTTHYDAIFGLLGLIWLYSVRWGTGYLTKKYPKYSRHLFFFNIMRNGILVIVGTLIAYLIQIGKASSPVSILKTVPSGFQAMGVPVVDTTLLGMVSGTLPSVVIILILEHVAIAKSFGRINNYKIKADQEIIAIGVANVIGSFFGAYPNTGSFSRTAIKARSGVRTPLAGVFSGLVVLLSLYALTPAFYYIPNAILSAVIIHAVADLASGPKFWKQLWLISPFEFFTFVAAILITFFTSVEYGIYVSVGLSIVSLLLRIARPRCAVLGRVPKKTQGGTSGFEEDVHYIYVKKNHPSLHHLVEDAPQGVVIFRFDESLTYPNASFISDKVMHHIQDNFSSAVPISTKKGDRAWNDHRPLPKKGEVLETVQDNGPRLYAIVLDCSAVNHLDSTGVQTLLDLRLAIDRLTEREVEWHFASLASPAIRNTLITSGFGTQAGRGPRTGELLPVVPAHRDGPQTTIDHTSTEQDIGHIHIDMDEKKSMRDRDIERNMGSSEKPYDSESECSLYENVSDKLSYCPRASRGLPIDRYPFFHWDLEDAVRAASYTASRAIRNNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UJ43</accession>
    <name>A0A162UJ43_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_143887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293683.1">
        <property type="nucleotide sequence ID" value="XM_018431090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UJ43"/>
    <dbReference type="GeneID" id="28991996"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143887"/>
    <dbReference type="InParanoid" id="A0A162UJ43"/>
    <dbReference type="OrthoDB" id="10566417at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="787"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="909" mass="102387" checksum="A261D237F09457BF" modified="2016-07-06" version="1">MSKAPNSSRFIESWIAKTEKETRKDDFDDLDQDMLKAIELSKQTHREEQTRLFAMFSDQSRSTSKVSFPKRRQQKSLFDDEDNENKINDNVQSRSVSKAADSNRKQFIPVRESIEELIQTHTTLPDKSSDKSRQKHIVIECEFSGNDRKKMNDKNDKGEEIVIEDVSTWLEELHSETPSHSKELINSSPPSSLIGNYKDDPPVVHTRTSYDSMASSMPSSLFGGDEYHKDRHTNKSSDKALNQLSSSPPDYFKQTECIDEKHPEDYHNQFGQGSFSDKFNKANDNHVDAQNKDHLDNFGWCSDNFDQIERTNSKLSGDSLDRQSLSPLSDQFVQEKCQDRTDIPDYNLNNYSWSPNSGIFGQIENTHIQVSKPNLQQLSSSPPSDLFGQIDQASKDQRVKGQDKPFWSPILDRHDHLDLAHTEKSKPNLRQLSSSPPSDLFGQINQAGKDQREKGQDKPSCSPISDRRDYLDLAHTEESKTTLRQLSSSPPSDLFGQINYGSEDKPKDKQGEPSWSPSLNAYDGFDDPHAEETNPTLRQLSSSPPSDLFGQTNCASTEHPSYTPRQLSSSPPSDLFGQIDYKSTGPEDARQFSSSPPLDSSHPTGHNDTDNSNEDFDEITSIPNSSTSDHKPTTEKAVPFGFRSSSRPIRIKKNPEIPEIPFSARKRSHATSPETPNYFEQRSSPSVLVNSDENSPLQPKEKSNQKHKIINPFKLDPVKQRRLQSDPPTSHNTEDVVGDFLSSWLTQGKTSNAPASVVPVFSKCPLCFHSFPDEVLQIHASGCRGGFTDTNDEHDQPQRTPRNPRTSNGNPRSRSNTSRQEDDETALDNPSTSTSHSHRGRTLVRQNRTIARSVARQDRHRHKPNRNETSLPAVNYYAEDDVLEGVEDGGFGGSLHGIAWESMGHTSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UM75</accession>
    <name>A0A162UM75_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_166265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294333.1">
        <property type="nucleotide sequence ID" value="XM_018435390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UM75"/>
    <dbReference type="STRING" id="763407.A0A162UM75"/>
    <dbReference type="GeneID" id="28996296"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166265"/>
    <dbReference type="InParanoid" id="A0A162UM75"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="126" mass="13584" checksum="3F75970293E72ECE" modified="2016-07-06" version="1">MNMGMNGIGLANDVMLNNGFNNLAQSGSPISQSLDATMSPSMTSTSMSANAMNPADLITNGIINPAMMLNNAPGLNMMGMYGGNNPGNEDAGNLQNVMMMMQRLQQQQQQQQQQQKEFEEAFTSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162USF9</accession>
    <name>A0A162USF9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_90478</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295802.1">
        <property type="nucleotide sequence ID" value="XM_018443753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162USF9"/>
    <dbReference type="FunCoup" id="A0A162USF9">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162USF9"/>
    <dbReference type="GeneID" id="29004658"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_90478"/>
    <dbReference type="InParanoid" id="A0A162USF9"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="136"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD77762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="281" mass="32859" checksum="1E5FFAF48D41B4A8" modified="2016-07-06" version="1" fragment="single">IDLWSEEMQAIWVPIAIYWVYSSIFELIMRAEIPFFEKYRIHTPEERNKRNKVSFKKVLLMVALQHIIQFAVAVYLFRPVDPQIKELERQTRLAATTRHLAVMLSWFGYDDRNNKLGLASTLATFLRSVALPAFQFLAAMTIMDFHQYVLHRLGHTNKFLYKHFHSHHHRLHVPFAFGALYNHPVEGFMLDTVGGALAYELTGMSPFLAMVFYTFSNLKTIGDHCGYSFPWDPLTVCFGNNVIYHDIHHQPYGIKKNFSQPFFTIWDRVFGTEFTEKDAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V4G6</accession>
    <name>A0A162V4G6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multicopper oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_14928</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297923.1">
        <property type="nucleotide sequence ID" value="XM_018432247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V4G6"/>
    <dbReference type="STRING" id="763407.A0A162V4G6"/>
    <dbReference type="GeneID" id="28993153"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_14928"/>
    <dbReference type="InParanoid" id="A0A162V4G6"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04206">
        <property type="entry name" value="CuRO_1_LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04205">
        <property type="entry name" value="CuRO_2_LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04207">
        <property type="entry name" value="CuRO_3_LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="123"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="380"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD79883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="514" mass="58342" checksum="4AD1154F805C7DB7" modified="2016-07-06" version="1">MLVNGQFPGPPIYVTKGDDVVITVHNRMETNSPSAIHYHGIRQYGSVASDGVPGVTQPLIQPGGSYVHKFRVQNQSGTFFYHAHAGMQDDTIQGPFIVYDDENSWPSSLGKQLSDGPFTYDDERIIHLSEWWRQHHHQRESYYLGPTFRFDHSAESILINGRTINNPLQIMNPATCPGYTALNVEPNKTYRFRIIGGNSFRTLALAIKDHPMTIIEVDGEKVVPYETSFLEITPGQRFSVLVHTANAEPGSAFAIATNYRYRHRGKGYTENGFGYMRYVAPGPGGKRPPRDFTYAKDFPVFPEEDGVGWIWDKLQPLQGRDQILDEQPDRTIKLRASIMKHGDNTTRYYMNGRPPIEHALPLYNSLTRGLRKTPRLEELEEDGYSAELKTYPLFYQETIDVVLQNAMGGIDCLLHPWHTHGHSHHLIASGVGEYNHEEHKDIRNFATPLYKDVSVVYPSEPDPVTRGCGWTKIRIKADNPGYWAIHCHITAHMLQGKMAVFEESPDLIEAFSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V9G7</accession>
    <name>A0A162V9G7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_97025</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299042.1">
        <property type="nucleotide sequence ID" value="XM_018443993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V9G7"/>
    <dbReference type="STRING" id="763407.A0A162V9G7"/>
    <dbReference type="GeneID" id="29004898"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_97025"/>
    <dbReference type="InParanoid" id="A0A162V9G7"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07751">
        <property type="entry name" value="PolyPPase_VTC4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="614"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="493"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="493"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="545"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD81002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="693" mass="79645" checksum="D6F309AB9572240E" modified="2016-07-06" version="1" fragment="single">MKYGAELQDNIFGPWRSSYVAYDALKKELKSRTQNRIWTDLDEYEFVCLLDNEHMKVHDFINAKLSEIDTRILYCERTIQSLQNSETMNSDASYTLMDETLTEILFDVNDLSRFTRVNFLAIQKILKKHDRWTLLNLRQEYVLKLREKPLDKQKFDVAIVYISALHDICRNRGKKHTGNSAAGGDQNAFERATAKYWIHPDNITEVKAIVMLHLPVLVFNTAKKWEPEDSAVSSVYFDNHNLDLYTGRLQRDEMAEAIRFRWYGPFESKNAFVERKTHHATWLNGASVKDRFRVNENRVNEFVSGAYTAEQIAQDFRATGADEAAVKDVHFIADGVQTSFREKQLEPMLRVFYNRTAFQLPGDQKLRISLDTDLTFIREDHTDGIHRRQNPPNNWRRTDVRTDYPFNHVKDSDILRFPYAVLETKLQTHLGQEPPTWLTKLIESHLVHEVPRFSKYLQGASHFYREKLPLLPWWLTEIDVDIRRARSENTGLTHTQYTNLRPDSKRQGSSSQNSATNQPLLDNDPLGGQLQSSKKQADQFYSPGKKTTASSSTVTNLGSGLSGSTANLTKEKKQKQGLGVPVAFDEEAQVGEKKKKSKKLKLEPKTFFANERTFIAWLQFCALLLSVALSLLNLGSDETARIMGGVFIGLAIVVALYALYLFEKRAWMINNHSEGRYDDIWGPAVLCILLVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162VA84</accession>
    <name>A0A162VA84_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_102333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018427712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162VA84"/>
    <dbReference type="GeneID" id="28988618"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_102333"/>
    <dbReference type="InParanoid" id="A0A162VA84"/>
    <dbReference type="OrthoDB" id="2439011at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="174" mass="19778" checksum="5B13E100453F76BE" modified="2016-07-06" version="1" fragment="single">PRSEQFKAENTILVGLMPGPKEPKSEEINHYLKPLVDKMIQLYLGIQIPTYQQTDGATVRAALLMVACDIPAARKTSGFTAHNSTCACYKCSNQFSRLPGTSSVDFHGFDCAQWRHRSDRANRVHAEEWNSASTPSERQQLKVEYGVRWSQLYRLGYFDLVRGTIIDPMHNLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WBL8</accession>
    <name>A0A162WBL8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_175618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441006">
        <property type="protein sequence ID" value="OAD66095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284135.1">
        <property type="nucleotide sequence ID" value="XM_018437528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WBL8"/>
    <dbReference type="GeneID" id="28998434"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175618"/>
    <dbReference type="InParanoid" id="A0A162WBL8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024368">
        <property type="entry name" value="Ecl1/2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12855">
        <property type="entry name" value="Ecl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="193" mass="21032" checksum="F3BE4045A6B29909" modified="2016-07-06" version="1">MSDLNWCTFCDHAISQYSESLYCSEKCLRDDALRNHPLLGYTYREFVDFPRPYSNKRPLLSTKQQSKQSQSSVYSPPISSTHTSSALSAITTITTNTIKSTAINTSTIYSNHCNRISTTSNISKSNNSISSRISTSSSSSSTTSTTSTTSTTSSSSSVSLPSVHNSPFNIHPTNSFLPKIPLSFVSLLSTQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WSS2</accession>
    <name>A0A162WSS2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fanconi anemia group I protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_64194</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018441252.1"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162WSS2"/>
    <dbReference type="GeneID" id="29002158"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64194"/>
    <dbReference type="InParanoid" id="A0A162WSS2"/>
    <dbReference type="OrthoDB" id="195089at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026171">
        <property type="entry name" value="FANCI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029310">
        <property type="entry name" value="FANCI_HD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029312">
        <property type="entry name" value="FANCI_HD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029308">
        <property type="entry name" value="FANCI_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029315">
        <property type="entry name" value="FANCI_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029313">
        <property type="entry name" value="FANCI_S3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029314">
        <property type="entry name" value="FANCI_S4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21818">
        <property type="entry name" value="BC025462 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21818:SF0">
        <property type="entry name" value="FANCONI ANEMIA GROUP I PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14679">
        <property type="entry name" value="FANCI_HD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14680">
        <property type="entry name" value="FANCI_HD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14675">
        <property type="entry name" value="FANCI_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14676">
        <property type="entry name" value="FANCI_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14677">
        <property type="entry name" value="FANCI_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14678">
        <property type="entry name" value="FANCI_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FANCI solenoid 1" evidence="2">
        <location>
            <begin position="166"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI solenoid 2" evidence="3">
        <location>
            <begin position="368"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI helical" evidence="7">
        <location>
            <begin position="581"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI solenoid 3" evidence="4">
        <location>
            <begin position="802"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI solenoid 4" evidence="5">
        <location>
            <begin position="1041"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1280"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1306"/>
            <end position="1327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD70725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1340" mass="151382" checksum="EB972FD3777EC3B8" modified="2016-07-06" version="1">MESTVIELSKQSQHQKLVDYLNEQPLEEITKSTLSQLNNGSLLNNDPIPFIRAIILGSPLDGGEDCINRRCALLDNIITWMSNDVESINGASAKIAANVANLIWPEARIFKNDNIDKLPVHDLHKASIRILNIIYEDKPMNPRLFEIISKVWNILSASDLAAEADKMLNDICKSEWHADVAMRLASAFNEMELTQKQLERVISQSLKQLAKLDPEEVPPFIYQLLLLSRKGHKRLILSGICDFFADCNKRPDNLEALSRTQGTVMLHISFAIKQDQELGIELVKYLKSERIKMLETFNMACLLSTARLHRLEDNIFDLIKTTIITIYRDTDRSRKNAWISKYFSVDGDAVKNLLLDIAERSASGWDQVIQSLTKLAMILIDTVANQGNGLKSSKNLVNNIDLCYHQYLMKMAVNKIDTVTVKPSKSAEQKPMDKISSVGIDILLKMFKLHDVVRGEILEQITSRIVSRSNSAVDFLQLLENIIKKHPHAAENYLNNIKDTLDFLSFLPNPAARQLLTAIQPVASENDQFRDGLMLVLRKSMFSKDQDGRMISVYGFLKLLQGHVSEDTIREGNNKATLSIASEEIAFEILGLLRRCFSQQIEVRAEAYEGLGRLAGQRTTLAGDIFEILYAQLLKIYQQDTGVPTPLKLDVCVENSLTGGRPRIVEPIPILLASILKTLRILDTMEHNSVTSESVKQCREHISSLTFRLSKADPDDYELDKSANFDASAYIGQRNLFYSELLLGSYEAVMEYEFMTQKNSQESCELVLNIFKKRKLLLQLVKENAAGDKGRKVTPYLSSKSILSLEFITSITQLMFSRDTVNSPINVLRSDINFVYYIVSATYNVLKEAIEDETNESGEENFTSCVILGKVYIHILMTEGPDSSFVESQPKKGVSTLGMLIDTLHGVFEIITKTWPNRFIEFTGSLLSSIENASDPKDYTSSNNLILSKMIENFESVVISYLSDRSPLYREATRVMQTIVFFSARLDRKAPGFTKCAQNIVTWLDGFVKERSIEDIPLAKEMVMTLIQISAEIDSFDTIIAISKDVHTILGDLEFEEDIDHNELNISYMLINEKTCGAITLQLLSFLDQAFEDMAWCIGHLKLSTDSAPEFELAVCKRMLSYLSITSELTKTVLVGIPAENLIKVLAKTYKTLLALVKYKISNLVEITDDFVAVIAMAGTGVTEKMYRFLTIYGQYQDDTIAQSGRKQKGKGKEPSNAREKAKIVREAKIIPNLIFVVEQFERHLIQLSRKSKKDLMQYMKRSTSRDFKIKADIVEEATTEDTQLKGSHAYETGDEDTGAQAGDGDQTEEEDQEEDQEEEEVEDQSEEQSSHTTKRRRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XYA3</accession>
    <name>A0A162XYA3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_109263</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295275.1">
        <property type="nucleotide sequence ID" value="XM_018428101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XYA3"/>
    <dbReference type="STRING" id="763407.A0A162XYA3"/>
    <dbReference type="GeneID" id="28989007"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_109263"/>
    <dbReference type="InParanoid" id="A0A162XYA3"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000499">
        <property type="entry name" value="Serine/threonine-protein kinase KIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF21">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="13"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD77235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="306" mass="34270" checksum="2AF5034FFEA72BDE" modified="2016-07-06" version="1">MKHNQAVPASQLYTKLKRVGKGAYGSVYKGVNNQTKKIVAIKVLNLDTEEDDVDDIQNEIALLSQLTHARSQNITPYYGSILNDTKLWIIMDYAAGGSVRTVMKAGDLEEKYISVITREVLLALAYLHKNRIIHRDIKAANILLTAEGSVQLCDFGVAGQVINSLKRNTFVGTPYWMAPEVIKEGASYDYKADIWSLGITVYEMATGNPPLSHVDPMRAVILIPRSKPPRLEDKFSPAIREFIDMCLCEDPEERLSAEELSKSKFIKGSSKTKSILREVIGRYDKWKKTSEAAKRCSIVSNDLSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y6V0</accession>
    <name>A0A162Y6V0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_62601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296685.1">
        <property type="nucleotide sequence ID" value="XM_018440989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y6V0"/>
    <dbReference type="GeneID" id="29001895"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_62601"/>
    <dbReference type="InParanoid" id="A0A162Y6V0"/>
    <dbReference type="OrthoDB" id="2267507at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="647" mass="75739" checksum="78A265ABA708EC16" modified="2016-07-06" version="1">MFSKKFCLLAKGQYTLLRTPNIMIPLFPFEILTKIGRLLSKQDQAECTHVCRAWKIPFQESMWNTIEILSDAKLDQICSSTTNGMPYHKNGHLVRTLFLEKWLKAEDRQLFTVQKRFQKINRLYIREKSVINRDFNNMADWSRWKSLTHMEICISGLYLENESRDFLKILECLPNLRWLECPQRYGYAWPYTLEEFDTIHSCIPKIEYLSLVLDLAPITEKHKTIIAETQPTSYLKVIKLRMNKVDLRWLRYFAHKYPNAHTIEWHSDIRSDTSNAFREEAISMFSTLSCAFQHLENILIDGTSGREWWYITFLDLLCHFKTTKAKRIEYRMRYGHSNLDLEKRIIHQCAQTCPTVMSLNFISSDLDLPDPTMIPVTIDFCPSILDLRIDALSLPIAVDILLDKCPSLKRLRLAVKSLSISKEATGTHGLRLIEFVGSKICTNVFSYLSFRCRCLNYLRLTKMEVVGPMFQGGCVCLDMSYTHLEYLQLTCVTVSASDGDDFNVSTVINLIALDQLNRVPQQDSVIKAALATKDIYPVFSKLLPWAHMYCIWDGGYEMIKLRKLVSEEAAYVQSYYQSFEQNKETYGSAHSFKRRRSYLGQLDQEHWKEDLDRGFVLFRCGSVRNYFIDTLGYYDDEFWEKLQTKFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y937</accession>
    <name>A0A162Y937_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_76978</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD79085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297125.1">
        <property type="nucleotide sequence ID" value="XM_018443212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y937"/>
    <dbReference type="STRING" id="763407.A0A162Y937"/>
    <dbReference type="GeneID" id="29004118"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_76978"/>
    <dbReference type="InParanoid" id="A0A162Y937"/>
    <dbReference type="OrthoDB" id="264917at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF42">
        <property type="entry name" value="LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN C14F5.10C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="13"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="123"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Lon N-terminal" evidence="6">
        <location>
            <begin position="200"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD79085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="52538" checksum="75CC8FAC086CFFCE" modified="2016-07-06" version="1">MNTTFQLTSLLTCAVCKEYLTDPISLSCGYTVCRTCLPPSTLLRKPTFVCPVSQCTSKAHLFGPQLFTDACVHGLSQLTRNTIDCYSRPPTPTSMDDGKNSLAIQNIQQGDHVIQSSTAMLQCHCCSQTMVNPITTHCGHTFCRLCVLQMKVTTDKCLNCKRPLPKFASLEAQAPNYLLESVKRGLQSAGAIRSLFANDSPFLSVTQWHETDIPLFTNGSLVLPNQPCRFPIFTAPLLRQMRHAIVSSSRYNGLCMAVVHQGLPSMAQFGTIVKIISVEHRHDAIIIDAIGLDRFKIEKYHQIEEDCMVASIEVLVDDEIVPRVDDHLHCSKRITNNANDDYAQALIDFGFMPPTYDTASTLHQRILDMVQSSPTPSLNISTEGLLGPVWFENMQQIYGPLPSPKEASRLCWWVASVLPGSNTERYAFLSTDRLSDRLETAILWINQLESQWTRCRSSAVHAISQAILQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YEW2</accession>
    <name>A0A162YEW2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_200779</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298295.1">
        <property type="nucleotide sequence ID" value="XM_018439719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YEW2"/>
    <dbReference type="STRING" id="763407.A0A162YEW2"/>
    <dbReference type="GeneID" id="29000625"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_200779"/>
    <dbReference type="InParanoid" id="A0A162YEW2"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD80255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="186" mass="21601" checksum="6FF6BD89704E500B" modified="2016-07-06" version="1">MLPIYKIVVLGDGGVGKTALTIQLLLNHFVETYDPTIEDSYRKQVTIDDQLSLLEVLDTAGQDEYTALRHHWIRDGEGFLLVYAITDKSTFQRIVRFKEEIFRVKEKENMPLILVGNKCDRETERQVSWEEGAQMARDMHCGFMETSAKLCINVENSFCSVARMIREDRKKTIKKVKVKRKRCLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YKD3</accession>
    <name>A0A162YKD3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_102175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299335.1">
        <property type="nucleotide sequence ID" value="XM_018427679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YKD3"/>
    <dbReference type="STRING" id="763407.A0A162YKD3"/>
    <dbReference type="GeneID" id="28988585"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_102175"/>
    <dbReference type="InParanoid" id="A0A162YKD3"/>
    <dbReference type="OrthoDB" id="3039677at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="180" mass="20189" checksum="5EC1FA75ED2FEFBD" modified="2016-07-06" version="1" fragment="single">NLPRLERYKKENVVLVGLMPGPKEAKTSEINHYLHPLVAELNQLYGGVVMPTIQCPSGALVRAALLLVACDIPAACKTCGFTSHSSTCACNKCNRQFPRLPDSNAVDYSGFVFSEWVSCTDAKNRHDAELWRMASSDAQRKRLERENSVRWSELHDLVYFNLMECIVIDPMPNLYLGTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZAD0</accession>
    <name>A0A162ZAD0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_153502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441028">
        <property type="protein sequence ID" value="OAD65421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283461.1">
        <property type="nucleotide sequence ID" value="XM_018433168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZAD0"/>
    <dbReference type="GeneID" id="28994074"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153502"/>
    <dbReference type="InParanoid" id="A0A162ZAD0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD65421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="80" mass="8488" checksum="333FFBAE63F3F556" modified="2016-07-06" version="1">MANYHLSEPPPASPIGLTGTSVPLVSAAISISILQSQLPLIPDRLVLTPNKDEFDSLAPVSIIDPSPRNSDSSSTWQSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZPR0</accession>
    <name>A0A162ZPR0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_150464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286321.1">
        <property type="nucleotide sequence ID" value="XM_018432480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZPR0"/>
    <dbReference type="GeneID" id="28993386"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150464"/>
    <dbReference type="InParanoid" id="A0A162ZPR0"/>
    <dbReference type="OrthoDB" id="7697666at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="282" mass="32914" checksum="A53C433C6295C700" modified="2016-07-06" version="1">MIVPLNITLLRNKIAKGFSFIKADKWKSWCLAYSLVLLAGRLLSENLDNWMHFVNACRYLAKPSITTVDLFHVHNCLKLFGQGGEDVHDKDFISPNMHLYMHLKEIVLNFGLVYRYWLFSFERYNGQLKNYKTNKRDGFEETFMRKYLEDAYKADLAHTILLLVHITLHHFLIYELIGSVPTLATAISIPVTFYLLTAYGFNLKNFLDSAVVTIDNVKGNEPLPSSVFPLNLEKFMPMEEDKYTYLLEYYKAAYNNTSLKSYRQAVFGKMFCEHFYPENSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZQ49</accession>
    <name>A0A162ZQ49_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_150522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286381.1">
        <property type="nucleotide sequence ID" value="XM_018432492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZQ49"/>
    <dbReference type="GeneID" id="28993398"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150522"/>
    <dbReference type="InParanoid" id="A0A162ZQ49"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="94" mass="10894" checksum="D0D790EE080232D4" modified="2016-07-06" version="1">MLEQDYIEGFGYRGIGSKISQETWGDHSCPSRHVTRLTHRRRQRPRVWYHPSRLTAGPNHRRNPPSGIPHQKLDKGVVAYNTHNKYKCPFSSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZRF4</accession>
    <name>A0A162ZRF4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_150188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286631.1">
        <property type="nucleotide sequence ID" value="XM_018432430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZRF4"/>
    <dbReference type="GeneID" id="28993336"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150188"/>
    <dbReference type="InParanoid" id="A0A162ZRF4"/>
    <dbReference type="OrthoDB" id="2280694at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="28734" checksum="81E13B9387C6F5D3" modified="2016-07-06" version="1">MSNINNINNTNDFVIVSETSKKYNAALTEFNSIFLVGREFSSVVAVQEAAKAYGVKHNIALTTEYASSSRIKLICKHSGEYRDTRKAKKVASKTSVMGETLPGWERKRKKDTQKHDCPCFMYANTKKGRKLTVRSREAEHNHPIEEDRRAYAMHHKLLPEAMALVVKHLENNDDVSTIFNSLKINGYTNIVHHDIANIKQHFGKLEKGKEMFDFITTLQDLDFHVRYSVGNTEDNQVNMVFFVYQDAINEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZTT3</accession>
    <name>A0A162ZTT3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_149979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287021.1">
        <property type="nucleotide sequence ID" value="XM_018432375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZTT3"/>
    <dbReference type="GeneID" id="28993281"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149979"/>
    <dbReference type="InParanoid" id="A0A162ZTT3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="125" mass="14974" checksum="34B8F046E6D229D4" modified="2016-07-06" version="1">MPFHELVKNNYGIDRNIDLLTQENLLLHTKKLPKATDRVASFVRSQQLLVDDLLALEHQRCLEIQECVLDNQVIRITIKPPGNSWRRIIHKYSSFRFLFDRHHETKRQKNFVAYYYPPMKPRQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZV02</accession>
    <name>A0A162ZV02_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2-oxoisovalerate dehydrogenase subunit alpha</fullName>
            <ecNumber evidence="9">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_156180</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the BCKDHA family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="9"/>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287231.1">
        <property type="nucleotide sequence ID" value="XM_018433471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZV02"/>
    <dbReference type="STRING" id="763407.A0A162ZV02"/>
    <dbReference type="GeneID" id="28994377"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_156180"/>
    <dbReference type="InParanoid" id="A0A162ZV02"/>
    <dbReference type="OrthoDB" id="3845at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000015">
        <property type="entry name" value="2-oxoisovalerate dehydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050771">
        <property type="entry name" value="Alpha-ketoacid_DH_E1_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="10">
        <location>
            <begin position="26"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD69191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="365" mass="41045" checksum="57C5568492C235D7" modified="2016-07-06" version="1">MDHSGNLLNETEHPGLDKDQVLNLYQKMIQLNVMDGIMYDAQRQGRISFYMTHYGEEALIGIAAALDSEDVVFGQYREAYMFLYRGLTVDECVSQCFGNELDMNKGRQMPVHYGSKKYNFQTISSPLATQIPQAAGSAYALKMAGNRNISVCFFGEGAASEGDFHAGLNMAATLSCPVIFICRNNGYAISTPSSEQYKGDGIASRGLGYGIDTIRIDGNDIWACYNATKKAREIAVTSNKPVLIEAMTYRAGHHSTSDDSTKYRNKKEVADIIQNDNPITRLRHYIENHGWWSQEDEDACRKQARKTVLDSFASAEKKKKPALENLFTDVYDELTPNLEAQKKELRELIAKYPEYYPTDEFKSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZXU4</accession>
    <name>A0A162ZXU4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cationic amino acid transporter C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_66061</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287761.1">
        <property type="nucleotide sequence ID" value="XM_018441579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZXU4"/>
    <dbReference type="STRING" id="763407.A0A162ZXU4"/>
    <dbReference type="GeneID" id="29002485"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_66061"/>
    <dbReference type="InParanoid" id="A0A162ZXU4"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF4">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD69721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="64067" checksum="22F8F28610D69BA0" modified="2016-07-06" version="1">MSSEKESVHVQSVSGHEIHETLRHRITTRYVTADPHSYLQRPDEKSSRFWVRRLGQIKPVELLLGEAEISGLNRALTSWQLIFLGIGAIIGTGIFVLSGTAAANNAGPAITISFIIAAIASAFAAFSYSEMASMIPVAGSAYTYAYATMGEFVAWIIGWDLILEYMVGAATVGVGWSGYFVKFFSVAANAHFSPSWTEPPIKWNESPTSISIEDGQYFNVPGFTIIMLVTIVLCIGIRESAWINSGIVIIKLLVILMFIFALCGFVDTNNYHPYIPPNTTGDWHKFGTPGIFAAATTVFFSYIGFDAVTTAALEAKNPKRDLPIGIFGSLIISTVLYLATCTVMTGAANYTLLGVSTPVTVAVDVVQLHTGKNFKWLNIIVTLGALCGLTSVLLINLLAQSRVFYSMAKDGLLPAFIATVHPRFKTPYIATLIVGTVTAILAAVLPVDLLGNMTSVGTLLAFFVVHAGVIVMRFTRPDVERRFRIPGGKYPSLLVPFCGMVVSILLIAVAEVTTIWRLFVWMGIGWIIYFAYGIRHSTLRRNPVGRFAEAHAGLAEATHIKRDSEGIQIEEYEHTPANEHENIPARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163A8P5</accession>
    <name>A0A163A8P5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_187663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289851.1">
        <property type="nucleotide sequence ID" value="XM_018439409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163A8P5"/>
    <dbReference type="STRING" id="763407.A0A163A8P5"/>
    <dbReference type="GeneID" id="29000315"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_187663"/>
    <dbReference type="InParanoid" id="A0A163A8P5"/>
    <dbReference type="OrthoDB" id="2250689at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD71811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="802" mass="86852" checksum="1D02070D43867B45" modified="2016-07-06" version="1">MSATLTQHFDGYIDSDFFRCPLCPPTEHTLFFSARAFSLHGSHKHKRKFVNDWKCYECAHSFATRDDFIHHDCVTSYVEPHLVRVPPILGKAPDFRPIDDFSVISTAKAFICPCCPRQYTEAYSLQRHHLLKHKRYLRIVWTCPCRCGFATVEKLDVTNHVKYDCSVGTDVDDVDLDNSICYGCDQYFPSCDIVAHRQTHPGFVDALAGTWRLPFAGTDLSSLHEIIGLVGWDSATVTQHLRQKRIWKHPNIISSFLHTSSNSPQQSGILSLVGNYPFSALSANVDVGVDYENDLDDTPIEAFDTPLGALDNTTSSVIDDGIEDNISSGYATPLAVSPALPPQPSLIFLLGKRTLNDRSPQQTGHRYTRPPAKTLASVAHDPQIASAAPIIVSASEQASNFLRGLDLKLPSLPFSSPSPSPSPQISPLLLASSAPVGDVLADILGDDATDASDTADNATAPVVDNSIIGDTAELALCNDGAPATVLSTLSASPPSSHLSSSSHDVSSSAVNWNDCWNMDPAHRARLFADQDRRNSAVAAHPVTPPLALPATLTPVSSLRPPPARRFAAIHPQRLALMESSAASSSPIVTFPLIGDSMHPSRTALLNLVNADAPILTPIDNLSSSLDVDVNVVPRRRSRRNKSAAVRPGQACVPAVRPMTVSMIEAALDSSNDDDENNDDNDNADVEAMEIYVEKVETKKTRRGRGKKSDRAKGKATIPEPPMLTHTPVSPASLVTDTCTPPIGPALDTLPGLSPLSPARWIHKWIVRVSKRDFSLELLSLLKSVPNSGALSSGSQYAKMRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ADE8</accession>
    <name>A0A163ADE8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_102363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290751.1">
        <property type="nucleotide sequence ID" value="XM_018427714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ADE8"/>
    <dbReference type="STRING" id="763407.A0A163ADE8"/>
    <dbReference type="GeneID" id="28988620"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_102363"/>
    <dbReference type="InParanoid" id="A0A163ADE8"/>
    <dbReference type="OrthoDB" id="2439011at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD72711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="172" mass="19503" checksum="26C7D2D026DD0E0F" modified="2016-07-06" version="1" fragment="single">RFKPENIILVGLMPGPKEPKTDEINSYLEPLVDGLKQLYVGMQIPTHEFPNSVSVCAALLMVACDIQATRKTSGFTVHNSTCACYRCSWQFTRLGSSNQVDFRGFNYSCWNIRSSAESRLHAEERKNASTLSERHQLEVKNGVQWLQLQRLGYFDLVCGTIIDPMHNLFLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AE34</accession>
    <name>A0A163AE34_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_146161</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290881.1">
        <property type="nucleotide sequence ID" value="XM_018431599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AE34"/>
    <dbReference type="STRING" id="763407.A0A163AE34"/>
    <dbReference type="GeneID" id="28992505"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146161"/>
    <dbReference type="InParanoid" id="A0A163AE34"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45793">
        <property type="entry name" value="HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45793:SF5">
        <property type="entry name" value="HOMEOTIC PROTEIN OCELLILESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="145"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="147"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="199"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="264"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD72841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="543" mass="61634" checksum="EFA1D1C1779BF636" modified="2016-07-06" version="1">MQSTTYHDNLNNDISCYCDDMNCRKQCQDSPESANSVYPIPFSNYTHPNEWQPRFLAAASPYSPYTPEAHLYGYPVYEEGSALEYGSGDCDNIYAPVCDCDQHNLHSSRESLFGGANESELPHRHHHDHHEHHHQNVFRPAFYDPFEIKHRRRTSRSQFKMLEKTFSETPKPNGPLRRWLAQQLSMTPRGVQVWFQNRRAKAKLQKQQQDRRHHLRSTSHVSREQSKTESHHVFSPPYAVPLKREHSGASHLTISVSSSINDLSHYSPSRGSPVGAEGQGYLPSQSAYTPPQSSIERPLSLQPYSDCATIIGDDDEEDDEEYSVHGKNGDGLFENQQLLMTPLTPYQPSCYVDVFNTQPQQDLVGGVVSLSTVMDQPLILSTLSDSQKHKHLDQPLDLSSFEYPVQDQELFGEQTNPSDPLVYINSLFNETHLGETAKANEYYGANSIDSWIQTLPAQASSGSDVRPDSVWNSQSGAMPFLDTSFQPQRSFDSLPVERRHSHPVHSKIFNEEETLRRLSEPIVDWINHLQPYNPVTGVSNVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B1P7</accession>
    <name>A0A163B1P7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_164699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295851.1">
        <property type="nucleotide sequence ID" value="XM_018435062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B1P7"/>
    <dbReference type="GeneID" id="28995968"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164699"/>
    <dbReference type="InParanoid" id="A0A163B1P7"/>
    <dbReference type="OrthoDB" id="2426083at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="228" mass="26480" checksum="13F7C67300EEDBEA" modified="2016-07-06" version="1">MAKDIEIGKIYSLGITVPLPQLSLNLDFRWYFYSENVTTFVKKILRTVATEYHIYSQCSLLALGRVTVLNTLILSQVWHFLQSMPMLEYFFDTLRNRMGQSLCKNMFPIAKLVSLCTSILAVELGVIKLQMGQKTRQIGWLDYILEPNIAEYFVPPWINYTLIPQHDSSDPHLPLLFPCLDNSYCFPRTIFRHGYCSSRLFIQHPHMAHMAHMAHMAHTIHIGCDHIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B9E4</accession>
    <name>A0A163B9E4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_164065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297011.1">
        <property type="nucleotide sequence ID" value="XM_018434927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B9E4"/>
    <dbReference type="GeneID" id="28995833"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164065"/>
    <dbReference type="InParanoid" id="A0A163B9E4"/>
    <dbReference type="OrthoDB" id="2384350at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="164" mass="18319" checksum="9220AB47B3430A5E" modified="2016-07-06" version="1">MNPTKNTRNTKSRLSLASEPTRHSFTPPNRRHTHALDTPRLSRSRSTQSSMSNFVRPIQNTNSLPLVPSISSPIPHTPHTPQLPHTSQSPHTSHTPHTPQTSHTPQSTTPNDHTILSGVIAYVDARTDDGDDVTESMERRVENLGAKVWNARHQKREQLDGLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BF08</accession>
    <name>A0A163BF08_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_161799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299211.1">
        <property type="nucleotide sequence ID" value="XM_018434474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BF08"/>
    <dbReference type="GeneID" id="28995380"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161799"/>
    <dbReference type="InParanoid" id="A0A163BF08"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD81171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="328" mass="37446" checksum="05971FA7818A9E30" modified="2016-07-06" version="1">MKADLHLSDYKNINNNTMAIQRRQLALRPVEITNEQLMEILSTLKTNMTAMGTNMAADMSIVQEQIGTVEDTLLNMNSRIGVLATSSTETITAIDSLSRAPLVSPTNTMANAHIRNLMWDPKLKTRNQADILANESKPRWNTNVFFYKSPNKELVVRLLENLKRKFTHEGFREADLRARLHKNFTSQVSKARKTEEEIKATNTRSRRAGRARDNHTRRLLAYTDNKEAIDLQMKRDCDFTMQMAAMSDGESADEDFENCTKSIVKIVRPGWRSDEFNTLIKLVDEYVIEAMGSSASQMKETVFTSVSNTAVPDDITPKFPQWALRDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163CVJ4</accession>
    <name>A0A163CVJ4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_152926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441007">
        <property type="protein sequence ID" value="OAD65900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283940.1">
        <property type="nucleotide sequence ID" value="XM_018433030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163CVJ4"/>
    <dbReference type="GeneID" id="28993936"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152926"/>
    <dbReference type="InParanoid" id="A0A163CVJ4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="56" mass="6239" checksum="F7A2ADCCE0F14214" modified="2016-07-06" version="1">MKRQQQNVTAASIDFRLSGIHTNKPTIRGLPLPRPYPSPPASTNVPKNKEPHHAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163D5M6</accession>
    <name>A0A163D5M6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_172763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286960.1">
        <property type="nucleotide sequence ID" value="XM_018436870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163D5M6"/>
    <dbReference type="GeneID" id="28997776"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172763"/>
    <dbReference type="InParanoid" id="A0A163D5M6"/>
    <dbReference type="OrthoDB" id="2288039at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="635" mass="68933" checksum="09138161E2026D88" modified="2016-07-06" version="1">MPIKTIYKFHQACLNHSGLSSVKMDNLMIWLDSEDIEDVEVHVPVGTPPEAATRTKPKIRNERRQRLIHRSLAYQVQEFNQTLIEQAKIVLPNANLHPIPFLIEQIDKKDRLAPHSLTYANNAQLKYSGEDDNSDKVVIKPTSRLKVLLEKTRNIEDIHFKRINSLLEYFADSENISYPEYKKYISPQPRPNVPPPLNTKLPTSPTTQTMSPTQNRFTPRPTTNTAQTIPQSQKNPNVPSIPKVSSSYDRARDPRLKPAHPPKPPTPSQTSTQKFQDNQPASAPNGSNVPNVSNVSNVSNGSNVSNGSNVSNGSNVSSGSNVSNGSISPVSSSFKSSNINNGPKTSNFPKNANPQGLSNTQNKNISRSLGVDARLPTNTPQQLQKQLGTIPKPNPYSNLPPPIPMPTQPANQFAIQKEAAARKIVNNPLKRKFEFGFTQNSPYSSSSASSYSAISSSGIPMVITSKTNPQNNKQSSSYSSSGVGVGSISGPGGGSGGGSGSGSGSDGGGTNPNPSKKAATAKTKSSGLPPDQPESLSDRGRIIILNVEPTSKKPRVICRTPAGDIVLGHPNEFDEACHSQHVNRSDDLHVRNYNKVPYFVCRDGNHWKIIGPVSRIEPVVRDFILKKGSSQVPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163D8W2</accession>
    <name>A0A163D8W2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_116157</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287640.1">
        <property type="nucleotide sequence ID" value="XM_018428504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163D8W2"/>
    <dbReference type="STRING" id="763407.A0A163D8W2"/>
    <dbReference type="GeneID" id="28989410"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_116157"/>
    <dbReference type="InParanoid" id="A0A163D8W2"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="7">
        <location>
            <begin position="29"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD69600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="284" mass="30231" checksum="084AE81023D9687D" modified="2016-07-06" version="1" fragment="single">SPSPDWGLSRISQRLSGTFDSYTYEATAGSGITVYVLDTGVNTEHSDFDNRASLSINLVHNEPETDMGGHGTHVAGKIAGKTYGVAKSARIRSVKILGQSGDGTTASLVKGISHVIETAEPGKSVINLSLSGPKSRMIDEVLSKAARDYNIPIFVSAGNAGTDACYFSPSSNQDVFVVGATNINDEVPLFSNVGQCVHLYAPGSNIKSTWIGSSTAIQSLDGTSMACPHVTGIAASLLSTKNYRNVHELYDEIRSIATKDLLKFKTVVHISQSHNLLAYAPYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DC21</accession>
    <name>A0A163DC21_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_126623</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288350.1">
        <property type="nucleotide sequence ID" value="XM_018429114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DC21"/>
    <dbReference type="STRING" id="763407.A0A163DC21"/>
    <dbReference type="GeneID" id="28990020"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_126623"/>
    <dbReference type="InParanoid" id="A0A163DC21"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF54">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD70310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="336" mass="37059" checksum="F8E845C9BA0232CC" modified="2016-07-06" version="1" fragment="single">MGQHGSKQHAPLTLGYLDRTTNATITNPPPIEQPAPDFVLENPHLYKLEVACCCDTPERDRNINISQTGLAEVASQECTVCQKNKRFSLVRKDLAKDLEYIDETYYPPEENTAESDPIQLDTEHHQDDDNDESDPLDSSVSQGLTKLTIGEATPDNKSTALSKPSLSVDLSGRALVRLSPTVGYLQNLTKLNISHNRITSLPRTIGHLKNLRTLNASHNLLESLPDTIAFVTMLKAINISSNKITSLPSSLGSLQKLVIIVAHDNKLTTLPRELVRLRKLLSLNVSNNPITAIPAEIATLKSLRKLVAEGCAFEQEFVTNLPHDPPSLFEYCARSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DRM7</accession>
    <name>A0A163DRM7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_113216</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD73000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291040.1">
        <property type="nucleotide sequence ID" value="XM_018428334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DRM7"/>
    <dbReference type="STRING" id="763407.A0A163DRM7"/>
    <dbReference type="GeneID" id="28989240"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_113216"/>
    <dbReference type="InParanoid" id="A0A163DRM7"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14016">
        <property type="entry name" value="STKc_CK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="56"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD73000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="322" mass="36435" checksum="65318A43233F8B6B" modified="2016-07-06" version="1" fragment="single">MASNAAYRRRASLGCDLRRPDEVTISLPSIGNASSLDSTSTELSANSRDVIIGDQWLVLAKIGWGSFGEVFKVQDIHDGMRYAVKRESHDVRNPQLKHESLVYDALFPGPGIPRCHWYGQHDDFDCIVIDLLGPSLKQLRESVADMPIDIVADLGCQMITIFEHIHHRGILYRDVKPENFLFPASCTVPKVYAVDFGLAAWWRNSTTHKPYPEARKPIRNKTGTARYASLNVHHGKAHARRDDMESLGYVLLDLARGSLPWTGIQARNPKIGWDTIGTLKEEASLQDVCAGLPSGFLKFIEYTRQLRFTEQPDYNFLRRLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163E0L5</accession>
    <name>A0A163E0L5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_167974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292610.1">
        <property type="nucleotide sequence ID" value="XM_018435769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163E0L5"/>
    <dbReference type="GeneID" id="28996675"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167974"/>
    <dbReference type="InParanoid" id="A0A163E0L5"/>
    <dbReference type="OrthoDB" id="2289822at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="267" mass="30155" checksum="E84EE7275BADDAFA" modified="2016-07-06" version="1">MDTENSNVSSNNVETREESVKERDDSLSLFSHLGAFKNTIESLLSFESVTNDKLFGMLNDTEQLNYKLISHYKCDKIISDTLNKNNTTKYDMGINGCKMYYSGDASIACCFCNEERQLADFLANSANFSKLVKYKKTIIENSLSVKEPVYKNIFNGSIFCGVRGMKELSLALNIDGFNSFKRGEISMTIIIATILDLPPTERYKQENIFIISIIPGPKKPKSLFSYLYLVTEKTALINNVARNSDFFQLSVFFEVQVKDVVLVGFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163E5K4</accession>
    <name>A0A163E5K4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_62993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294850.1">
        <property type="nucleotide sequence ID" value="XM_018441053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163E5K4"/>
    <dbReference type="GeneID" id="29001959"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_62993"/>
    <dbReference type="InParanoid" id="A0A163E5K4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="249" mass="28772" checksum="CFA056359BEC7F28" modified="2016-07-06" version="1">MYESSAFQDETVPHQQYNTLVQVYRTRRRQILSHFETRIECSLSVICDITVKKTQTRTRRAPLYSKMPRLVLQNNFGNRTYDLSSKTNFVPVISLSVELGQLILANCYKCVSLNLTSLVNCAGLFFYFIYSVSNFEFYFYFYFHITVCGTRCLALRGNLGSIEVKTMTNLACLGFSDQLWRFISISFTFISTNLPNHIKIHKVLCRKEKEEEEDFSCCLSIYLSPQILSSHLFFLFAILLLVPVALGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ELX9</accession>
    <name>A0A163ELX9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate esterase family 4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_89094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297440.1">
        <property type="nucleotide sequence ID" value="XM_018443707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ELX9"/>
    <dbReference type="STRING" id="763407.A0A163ELX9"/>
    <dbReference type="GeneID" id="29004612"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_89094"/>
    <dbReference type="InParanoid" id="A0A163ELX9"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10952">
        <property type="entry name" value="CE4_MrCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF98">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="135"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD79400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="399" mass="42308" checksum="BDE0782ED30EED71" modified="2016-07-06" version="1" fragment="single">TTSTTSSTDTNSGGVPAQVSPSWLSDIQPMAGNVQSYPTGPVPTGPFTAAVGPLTGYPQAWKAPDPTSAEVVAVINSLDWTQVPNSAVRQAGSGGGVKMTGYSASDPDCWWSASGCTVSKRSNIPADVAFCPTAGDWGLTYDDGPLTADAGQWAEPNLYDSLAANNQKAGLFYIGSNVVNAPAAAQRALADGHTICVHTWSHPAMTSQTNQQIVAQFYWTLRAIKEVTGVTPRCWRPPYGDVDDRVRAIAWQMGMTTVLWDQDTNDWNMPGSGGGNLPPATVDGYFEKWINARKSGTDNQRGHIVLQHELNDATVSMAEKWLPQVQEAFRLVPWNECVQMAYPYWEENFVYPPGNPTASSSSDSAAGISSVSPSTTQDATLSVGSSGVGSGAESTTSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EPF2</accession>
    <name>A0A163EPF2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_178681</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298660.1">
        <property type="nucleotide sequence ID" value="XM_018438026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EPF2"/>
    <dbReference type="STRING" id="763407.A0A163EPF2"/>
    <dbReference type="GeneID" id="28998932"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_178681"/>
    <dbReference type="InParanoid" id="A0A163EPF2"/>
    <dbReference type="OrthoDB" id="3257538at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052145">
        <property type="entry name" value="Mediator/Homeobox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330">
        <property type="entry name" value="HOMEOBOX PROTEIN BARH-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330:SF19">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="7">
        <location>
            <begin position="418"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="351"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD80620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="479" mass="54301" checksum="D9643C98E2376E54" modified="2016-07-06" version="1">MTLPASNEPAVSSTEPTSKKIVKSVSVSETTTTTTTTTTETATATTTATTTTEGDTKTAVAKETGEEVYEDRFLEGNQRIIAYDLLEARGKASETTDPDVQRYKKAKELFRKGYDLCMSIPRSLEEDVLEKYEHEVRSSAEDMIEAWLMDEKAAPMSERVLILGQQYEKVLLRNIPEEQKEGFFIKESLLFSAWILLVGKQFQHCITTLTLAIDTYDDLPACVYFIRASCHLSMNKLRLGIKDLETSLEKDPKFVISYSVIGSVYMSLKENENAVRNFKLYVQKGHPDTTNYFSCLYSLSVLLSHQKGKKAEAREFYAKARKAEGRFQELYGTTTSMNETKREAIMSFGSKEEIATLNQQLELQRQQHQQQQQQQQQQQQQQQQQIQGAPSQQYNAKIEQLIQSGFLSSPFPPNPKQCSNCGASRRKDATDKPLFCCGACKGIWYCVRECQVEDYKRHKVVCKKSPKNAKAAETQQPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167J8A8</accession>
    <name>A0A167J8A8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_153365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441010">
        <property type="protein sequence ID" value="OAD65467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283507.1">
        <property type="nucleotide sequence ID" value="XM_018433127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167J8A8"/>
    <dbReference type="GeneID" id="28994033"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153365"/>
    <dbReference type="InParanoid" id="A0A167J8A8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="121" mass="14229" checksum="A1AAA53F5BCD0EA0" modified="2016-07-06" version="1">MSNIDYPQLLDYYKIAYAMPNPISYHDTRLSQYFPPHSNHRASTLHQDQHVFAYIRWYNSTNDNEHRDEGIAICLPEFSADNYHSILPVHCIHLEVATAVDVTDMNEKRMLVIPMPKKYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JMF1</accession>
    <name>A0A167JMF1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_41755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441004">
        <property type="protein sequence ID" value="OAD66306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284346.1">
        <property type="nucleotide sequence ID" value="XM_018440167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JMF1"/>
    <dbReference type="FunCoup" id="A0A167JMF1">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167JMF1"/>
    <dbReference type="GeneID" id="29001073"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_41755"/>
    <dbReference type="InParanoid" id="A0A167JMF1"/>
    <dbReference type="OrthoDB" id="2011986at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018810">
        <property type="entry name" value="UPF0662"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086:SF1">
        <property type="entry name" value="CU(2+) SUPPRESSING AND BLEOMYCIN SENSITIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086">
        <property type="entry name" value="UPF0662 PROTEIN YPL260W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10303">
        <property type="entry name" value="DUF2408"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="428" mass="49073" checksum="079F7D1AE10D5FB3" modified="2016-07-06" version="1">MYKEIPVLESLLTIRHKLSALKKDRDSYPKPDLIVDLYHDTEQQVELITAIRANQVWETSTRNRLNDVLDDVMSLLSLFFLSMGRNRESPAVYAQLVTVERYLDQLSQMGIYTDSILLEIRSRLADIESIVFADSSSSNVSPCFLDLLKKKLTRCKTLLENLLSTIHEVSPALKPIHDELVSLRHDLAAVASRPSGFKAQDIRPFQIKLRQIDNARSELVMPDDRIPKGQALIVGLLEQLYEETHDLIASTDNISESLLPIADRLKEIKGQLERLALTHRWTLRETDLYTFQLQLQEIEKLRCKGKFRDAQSNAPDGQVLINFLLRGCYRLMSKMLSENVPVAEALMPVHNQLSTLRRCLVEVRKWGKPDSPRELYPYQMKLNSIDKLRQDGVFYDEEGNIPEGQAICIALLNECYDILHELLSSIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JY79</accession>
    <name>A0A167JY79_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIF subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TFIIF medium subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TFIIF-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_183697</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD66909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284949.1">
        <property type="nucleotide sequence ID" value="XM_018438815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JY79"/>
    <dbReference type="FunCoup" id="A0A167JY79">
        <property type="interactions" value="485"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167JY79"/>
    <dbReference type="GeneID" id="28999721"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_183697"/>
    <dbReference type="InParanoid" id="A0A167JY79"/>
    <dbReference type="OrthoDB" id="26094at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07980">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="12">
        <location>
            <begin position="40"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="11">
        <location>
            <begin position="196"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="253"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD66909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="296" mass="33188" checksum="135DD799878FFD59" modified="2016-07-06" version="1">MPDSRTNPDVDALFEDDPGSLDEVVDDEDAEDLKLDNANTKVPKFLANKWKAIDQDNVNLGSVRIYSQPPPGRSSAISLVLPENEVTENIPREYSISILPGEVTNKFVFTESEHGGKSISGRVHHECAATPTQFGTYRDIMRKRVIDAGTPQRTVQVLGQDNQPVFVPGASSSMPSSSFSDFVTAKKPRTDKEKATRMPRNELMDLLFAAFDRYPYWSFKGIVEHTKQPAQYLKEILSEICILNKRGPYAGNYQLKPEYKQRSAAERPNGDKEDSKDISSSEEDDEEEEAMEAIHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KIY6</accession>
    <name>A0A167KIY6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_150866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286247.1">
        <property type="nucleotide sequence ID" value="XM_018432559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KIY6"/>
    <dbReference type="GeneID" id="28993465"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150866"/>
    <dbReference type="InParanoid" id="A0A167KIY6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="117" mass="13021" checksum="83ADBF17F13A3F18" modified="2016-07-06" version="1">MDPAPPPEVHLIDYGLNCLPRSFKSLGTWCDWWPCLLALLRAVDKTTSSYKLPEEKAHGQILIDLAAKFRATKPTRPHRIPLPTQEPVPGDPFPHLLSEISTVPRQPPPSVPARNCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KJP8</accession>
    <name>A0A167KJP8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_117567</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286289.1">
        <property type="nucleotide sequence ID" value="XM_018428585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KJP8"/>
    <dbReference type="FunCoup" id="A0A167KJP8">
        <property type="interactions" value="554"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167KJP8"/>
    <dbReference type="GeneID" id="28989491"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_117567"/>
    <dbReference type="InParanoid" id="A0A167KJP8"/>
    <dbReference type="OrthoDB" id="10254737at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233:SF14">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD68249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="405" mass="45622" checksum="BBBAA27CAC30B1CA" modified="2016-07-06" version="1">MEKQQRLNAGLPKSAKKAAEIEPKKPVVAATVNQDDKAKKTQKTQKIQENDVPWLLHLDTPKRPDSSTLDLHPAVLTLGLYFSEFKIVGSNARCVAMLETFSKASVIEEHKPPSDATFSRHIQKHLDPQIAYLLSTRPMSLSMRECIRWLKKEMSDIVEEDPPLSDDDARHRLMDRIEHFIRERITMADRLIVQYGLQKIQDGEVILTYGKSSVVESLLLEAKKKGIEFKVIVVDSRPLFEGKHLIRRLVAAGIDCSYHLLSSVYVALRSVTKVLMGAHALLNNGAVYSRIGSAMVAMAASDKQIPVMICCETYKFVNRTQVDSFVMNEIGNPDALVNTKPTYNANHLDQPTSDVSVLTSWREQPNLRLLNLLYDVTPSKYITLVVTEVGLIPCTSAPVIWREYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KMM6</accession>
    <name>A0A167KMM6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_68999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286479.1">
        <property type="nucleotide sequence ID" value="XM_018442040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KMM6"/>
    <dbReference type="GeneID" id="29002946"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_68999"/>
    <dbReference type="InParanoid" id="A0A167KMM6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="163" mass="18955" checksum="CB2BE76248F8562F" modified="2016-07-06" version="1">MLSCKHDNRIFFPYILFSQQHLFSQTSSRFIFKPVINICNVTLEHVYQMMSQHLGIKVTASKKATLRTYAIKIGHPLQESVISGKIIKGDNYFLCQRLKVLPCSSERLFGMSLIFGMDPTNISAVLRGIEDIIYEKIRWRIQFNTHLFLVLFWIFVSPFSGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KQL0</accession>
    <name>A0A167KQL0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_136235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286687.1">
        <property type="nucleotide sequence ID" value="XM_018429772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KQL0"/>
    <dbReference type="STRING" id="763407.A0A167KQL0"/>
    <dbReference type="GeneID" id="28990678"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_136235"/>
    <dbReference type="InParanoid" id="A0A167KQL0"/>
    <dbReference type="OrthoDB" id="5586934at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="262" mass="29174" checksum="66E8D8ADD6BF787C" modified="2016-07-06" version="1">MTKLHIFQRVANVLVYLFFLSATVYSVVAPPPDDEVGHEGLTYITPSFWVSSIWTVIHFLLGGFVIYQWFEPAHAAALHGVGWHFVISVLLSAGWLALLKSGHFIIGFIFVLLTASSVSFVFYNLEKNYPTSSIYDKLFIHAPFSLWHGWIVFSAVVNLFQAFTGLKEDGPTVFLRILVIFGILFLTSTAVGYVEYKKTKGDLTGAFVIGLGLVAIFTNQSDPWIHWTALGAAIITFIYPARPYVFKLVGRDTDAENSPLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KYF4</accession>
    <name>A0A167KYF4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_172425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287209.1">
        <property type="nucleotide sequence ID" value="XM_018436799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KYF4"/>
    <dbReference type="STRING" id="763407.A0A167KYF4"/>
    <dbReference type="GeneID" id="28997705"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172425"/>
    <dbReference type="InParanoid" id="A0A167KYF4"/>
    <dbReference type="OrthoDB" id="2285345at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="328" mass="37536" checksum="7E19A83B1D53E986" modified="2016-07-06" version="1">MSTVNIIPTNETIYTLATISEALECSSIPGVMTLRLNSTIRVRTSEWKECLVELSGFYAVKWTIHNSNKQHTDITAEEAKKVALRYASHRSTCVIVQEFMNLRQRCEQFFKIPEWYEITLTKDHADNTPGDIHKDIYTLSLAKNYLHELFQQLEQASKSASQIRIDMLRAIDRYGRSSDYQMVSFLIWINEKLLAINFSIFKGNMSYSPNTNAFAYSFMSPTQQIKMRNAVSFCLDATHAISGKTDEILYTLLVCDEEIGRGWPVTFMVTNDRGVGPIVQWLLFLKSFLLLINPQQFTIDCCSAEVHAIQTTFPSTQIQFCIFHGTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KZB2</accession>
    <name>A0A167KZB2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_159876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287257.1">
        <property type="nucleotide sequence ID" value="XM_018434078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KZB2"/>
    <dbReference type="STRING" id="763407.A0A167KZB2"/>
    <dbReference type="GeneID" id="28994984"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159876"/>
    <dbReference type="InParanoid" id="A0A167KZB2"/>
    <dbReference type="OrthoDB" id="2381286at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="132" mass="14952" checksum="8A8C6FE6EB29DED0" modified="2016-07-06" version="1">MPHKAGSISPKDNKKNKKDTSPERKVRQITVQSINKEHRVWIVVEPTETGLSLAEKIHQIATFRTRKILTITSASGRQVPLDNRPVFGSWSDMESFQDGEGWQVTWGDLDKSVVDRIFSKVVQVGGRKKDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LBJ2</accession>
    <name>A0A167LBJ2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_71511</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288107.1">
        <property type="nucleotide sequence ID" value="XM_018442485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LBJ2"/>
    <dbReference type="STRING" id="763407.A0A167LBJ2"/>
    <dbReference type="GeneID" id="29003391"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71511"/>
    <dbReference type="InParanoid" id="A0A167LBJ2"/>
    <dbReference type="OrthoDB" id="2206543at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD70067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="642" mass="70691" checksum="5312055932FD80E9" modified="2016-07-06" version="1">MTITQNSLLRTTTKLSIFLSELTLVNKSGSYKQPMFKIVNILVEDITGQQASKTYYFTSVRKEISDRDLTFLSSLFFYLRLRFPVGFTNFGCVIALEEQPRSKTTHCQEFGQNKNNSQHSDTRAGLIVIVVFIYLPIFIFLIDFFFKLLESSLQSSSHLRRNHSRLSASPTTSQLPVPLLSSPVLFSFSEGGSGVLPSTSHFFVPVSDLSFSALPAPGSHEIFFQAPPTMIGSQKQVINSTGRPTPTALILSGLKADFKKLHNVLSCSHCQTTGKIVSNGSTSRTGSPQFKCKCGATFTASSMQSLINAVQHKIPEVHSASEPVVSPSVSILGHSISMADIHEIESDIAPVLPTVMPTLQDIWDRFQAYDERLSALEAVQKENIELRKALATANATIARLTKENVDFSVGAAASKYATIAASVPVVSQADFPSLPASPTHHSTEPTKTFVSKTPRKRAPTARAIAAVVRGMTIKENADQGFQIVYVPNAIRLPISTQRQRLRKLKIDNARVLDLHYPDRKVMGMLVHNEYAPELKTILASYGVTTLDNFDPLDPVHLRDPALASLSLDDRATKAIHVHNDRMLRAIEFIRAPVKFAVARSFCSQGWISDDQLAEIVPPRPTKKDLDISIHTASITIPSFSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LLE0</accession>
    <name>A0A167LLE0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation machinery associated TMA7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_148610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288738.1">
        <property type="nucleotide sequence ID" value="XM_018432114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LLE0"/>
    <dbReference type="STRING" id="763407.A0A167LLE0"/>
    <dbReference type="GeneID" id="28993020"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148610"/>
    <dbReference type="InParanoid" id="A0A167LLE0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015157">
        <property type="entry name" value="TMA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28632">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09072">
        <property type="entry name" value="TMA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="65" mass="7173" checksum="F0CDCDBD514E4F4D" modified="2016-07-06" version="1">MSGRQGGKLKPLKAPKKKQFDDEDDEDLAFKKKQMEENKKLKEMQAKAAGKGPLLSGGIKKSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LPS8</accession>
    <name>A0A167LPS8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidate phosphatase APP1 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_64058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288908.1">
        <property type="nucleotide sequence ID" value="XM_018441225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LPS8"/>
    <dbReference type="STRING" id="763407.A0A167LPS8"/>
    <dbReference type="GeneID" id="29002131"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_64058"/>
    <dbReference type="InParanoid" id="A0A167LPS8"/>
    <dbReference type="OrthoDB" id="2117591at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF3">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="1">
        <location>
            <begin position="310"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="691" mass="78551" checksum="D4CFE6740FC1A11F" modified="2016-07-06" version="1">MAAVSHQPYSHILDTSAPLYQEPASLDLDTLLLDDTAEQPFSTDELQKECILFPTYAMQSPTDPSLWIIRVKAWALSHKTSGTKQRLMMGITKSVAKAASTDPKTTHMFEKRFSYFMAKNKRNKVFIIKATGPISLQDSRRDPYSLSSSLNDDEQFPGLYETEAIDYASYLNRPFSWTTPPFGRPKNPLSIVLNSSIVSRAMSGSLIDRYTTYDCPSYFDYLQNTPPLNTGSSQHPLDPLQESFVSENTGFFGGTFEISDEQVQNWAKQHGLCDPRLIQLRSDPSPQPNPTKSNFLPTTGLVSLIRPSGISIISDIDDTIKDTRVLNGARTVISNTFFKEPKDVDGMADAYMGWYTQGASFHYVSNSPFQLLPMLDRFIHQNQFPPGSIHLRADSSLFSRLVKVAGQAKRDAILLIMSDFPHRRFVLVGDSGEIDLEIYSQIALENPGRILKIFIRDVTTPFFDQPSSTSTSSVSAKQTWIQSTTRRSGSFLSLLLSSKRKMSEDSQDSDDQEHGYNHDAMVSAEINRIKNRENEENKESDEKNIHILNIQMPGIKLTEPVDERVTLTERYDGLSRSLDNRNSKNLLDVKEWHTKAWLEETEEKSKSETEEEEEERIRRRGIRRRWSDQDNLIIKSQESERLSERLAAARAAVPAVDIVLFSNAEELSQDNQVRDALWKHWDDQSMQQKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M1R3</accession>
    <name>A0A167M1R3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_72104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289569.1">
        <property type="nucleotide sequence ID" value="XM_018442595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M1R3"/>
    <dbReference type="GeneID" id="29003501"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_72104"/>
    <dbReference type="InParanoid" id="A0A167M1R3"/>
    <dbReference type="OrthoDB" id="2289822at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="500" mass="55641" checksum="55C8ADC6EF21E808" modified="2016-07-06" version="1">MATGDIPALAKLACHAGHTSKNGCHICNVVGQTPGHGQYFRTLPGTTIRTVESFRSFNPDSALWKGLKRQSPFASLTSFTGPFFFALNEMHGLCHGIGKQVWGLVCGKTEGDRRSNGRNKMIDPNIFLWCLEGRGKTRRIFLSCGLSRFPSVCGSHSGGRACPQSRCTEGIAWPCASMHSTHELGVISRGTNLYKKSFVFGTYSDLSLRNLIKWNSYLKGHFQNGKVGIEIFTIHQHLLQHYPAMINAFGPPRAYSTRLLERAIGEYSQSIKSNSAIGANAGNIMLRLAHTRRVDINGASVVKARTTARILQYNDESAGWLMTEEDSAFAHKVQREAYHVCLQSQINKATNARPGSSPALKDFFGKVVLFFEHVNEGKRWPLALVLVYSTMLYNGVPVARNGQMKPKVVHLADVKELVGLVVSDATVNITTATMTAYIVWPELNYGPKLHQGNFDKKTLSQFEIEERVQDLLLSKLVNNYKNNRHVPYIPEEHRLKSTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M3X3</accession>
    <name>A0A167M3X3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptide hydrolase</fullName>
            <ecNumber evidence="10">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_88687</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family. M28A subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="10"/>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289754.1">
        <property type="nucleotide sequence ID" value="XM_018443696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M3X3"/>
    <dbReference type="STRING" id="763407.A0A167M3X3"/>
    <dbReference type="GeneID" id="29004601"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_88687"/>
    <dbReference type="InParanoid" id="A0A167M3X3"/>
    <dbReference type="OrthoDB" id="10013407at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03876">
        <property type="entry name" value="M28_SGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041756">
        <property type="entry name" value="M28_SGAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF26">
        <property type="entry name" value="PEPTIDASE M28 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="9 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PA" evidence="11">
        <location>
            <begin position="99"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="12">
        <location>
            <begin position="210"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD71714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="434" mass="46870" checksum="F6C6C1BF89844542" modified="2016-07-06" version="1" fragment="single">LQQNLTIEGLLRHSHKLQKIADKNHHTRVFGSGGHNDTLSYIASSVLEQGYHTWLEPMVLNFTQTLHQSASVIFPPTPEPILNVRLMTFTTSTPVSGATGSLVRIGGLACDEIDQDLGGKIALVQRGECTFGAKAYWAGQAGASALLIYNTEPGSLSGTLGQDYESGAPTGGISREDGERLIRLLDEPWHPDVVLTVRLVEKREARLTYNVIAETKGGDKSNIIVIGAHSDSVAAGPGINDNGSGTAALLELAYLFRNEKPVNAVRFCWWTAEEYGLLGAKHHVDNLTKEEQKDIALYLNFDMIGSPNYYNGIYDGDGSDSPMAGPPGSAAIEKLFQDFFESKDEAHDPSEFDGRSDYGPFAAGIPSGGLFTGAEVPKTEEQAKKYGGEAGVAYDSCYHESCDDINNLNHHAFLLHARGLAHALAVYSQSTESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MHZ5</accession>
    <name>A0A167MHZ5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_77981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290936.1">
        <property type="nucleotide sequence ID" value="XM_018443320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MHZ5"/>
    <dbReference type="STRING" id="763407.A0A167MHZ5"/>
    <dbReference type="GeneID" id="29004225"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_77981"/>
    <dbReference type="InParanoid" id="A0A167MHZ5"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="312" mass="35885" checksum="719354F7A94AF6D1" modified="2016-07-06" version="1">MSRKRRYSSIDIAMQMQRINHRPWAALLNHKVTRSLITVALLVLLLVPSGVVMKVFIQLSVILSNYPDGLIKAWSSSSIKDVFTTSQIDVHVLAASSSSETAVRVIYSPFPVCFRLSSSDNYDLFNSRALNLFLFPFSDERFWQLILCRLEHFHLGFFLIGSVNNIWLTYKILDDMFDLVLIGSDTLQDGVQVEGEEEEEEEEEEPNLPTINRRVGKLVKSMLLFHCCTLVVLFWIHFNLLAFHTDSPQNDPQTYNTRQFLAELPMWTLRWVTLGIAVGDFALRSIYRWLGRISNCVAEEEVLTSPENQPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MZB4</accession>
    <name>A0A167MZB4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_67504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292619.1">
        <property type="nucleotide sequence ID" value="XM_018441804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MZB4"/>
    <dbReference type="GeneID" id="29002710"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_67504"/>
    <dbReference type="InParanoid" id="A0A167MZB4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="146" mass="16485" checksum="3828E637D2B53198" modified="2016-07-06" version="1">MEQALLTRDNAPSAILLLPTTGDHDIKWPSPKGKSGGWNQLVKCFKEVLVTHFTRGDLIKAKQMYRVVGKITQELVHYSFSKYSTNNIAIPSWGSLADDQKAIMSSSLEENAALKNIALHRFENSWGALLILSHKWRTAKYHGRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N1V3</accession>
    <name>A0A167N1V3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_132906</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292794.1">
        <property type="nucleotide sequence ID" value="XM_018429532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N1V3"/>
    <dbReference type="STRING" id="763407.A0A167N1V3"/>
    <dbReference type="GeneID" id="28990438"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_132906"/>
    <dbReference type="InParanoid" id="A0A167N1V3"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017348">
        <property type="entry name" value="PIM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF72">
        <property type="entry name" value="CAMK PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037993">
        <property type="entry name" value="STPK_Pim-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="34"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR037993-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR037993-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD74754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="298" mass="34264" checksum="79123ED73898159B" modified="2016-07-06" version="1">MPSPPSTPRQTVQETLSSQYLRNRRLAPDFLEKYALGQELGSGGFGFVLSAYERYTGIERAVKFIFRDKVPASAWIRDRQMGPIPMEIYVLKHVRHPNMIQYIDSYQDDSFFYLPDAIFGRRSSCDLFECIEQHQNFDEPLAKNIFRQIASCVAQLDKLGICHRDIKDENIVIDRNYQVKLIDFGSAVILPRHYGDNRPCLFTKFYGTVSFASPEILQCQPYLAEPAEVWSLGVLLYTILFGEVPFHGPHMTLTGRFAQPKINVSEKCMHLVKSMLEISPAKRPSIHQILTHPWLADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N6E3</accession>
    <name>A0A167N6E3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_167449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293169.1">
        <property type="nucleotide sequence ID" value="XM_018435641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N6E3"/>
    <dbReference type="STRING" id="763407.A0A167N6E3"/>
    <dbReference type="GeneID" id="28996547"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167449"/>
    <dbReference type="InParanoid" id="A0A167N6E3"/>
    <dbReference type="OrthoDB" id="2262293at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="254" mass="28147" checksum="3709B4C98E9C2DE4" modified="2016-07-06" version="1">MSIRGAAKELKIPPCTAQTWYTKDQKSIESGEDLYLRKPGNERPVGRPLTINSEQKKYLINLIDQKPGIVLDEMMDGLTSQFTNLDISRSSLYKYVAAHCGMSVKRALFRPAERNSDTKIEARFQWVTELLKTDIDYITDCVFINESGFNIDMKRSMAWAPVGETPIVEIPKTRATSHTTIGAISPLGVINVQLKVSKVVVASNSKKRKGPGGAIKKPEKEKGKGGTCVNNFETLCISRIVNGKIIRQTQGKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NGT8</accession>
    <name>A0A167NGT8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_142862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293918.1">
        <property type="nucleotide sequence ID" value="XM_018430885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NGT8"/>
    <dbReference type="GeneID" id="28991791"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_142862"/>
    <dbReference type="InParanoid" id="A0A167NGT8"/>
    <dbReference type="OrthoDB" id="2379098at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="251" mass="28542" checksum="48246081E8D8608A" modified="2016-07-06" version="1">MGRKNARSVLTSKMPRRQDGKFCAKPPVIVNDTESSAAEEEPVEENDWELLDLTTDMMVAGYYRALARLEKETKDDLRALNKRDSRPSSIRNKRKAKGELEANKDKKVRTLADFGFSVPVKQVSPTTTTLIVDKKPNDKKLEKIRGAFEMISDKLNPLLGSDNQLIKSALFEDTKQIVLRDYFRRLLENSGKIEASERAAELMWDSPSKYCGAKVRAWAKEFLELGGIPGHQQDKHDKRSSIVDDEDLKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NIA0</accession>
    <name>A0A167NIA0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_59500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294009.1">
        <property type="nucleotide sequence ID" value="XM_018440508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NIA0"/>
    <dbReference type="STRING" id="763407.A0A167NIA0"/>
    <dbReference type="GeneID" id="29001414"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_59500"/>
    <dbReference type="InParanoid" id="A0A167NIA0"/>
    <dbReference type="OrthoDB" id="2447509at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="433"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="599" mass="68184" checksum="04F8D4FC89FD8A4E" modified="2016-07-06" version="1">MSSTQRCCAACHMLRHSRSTHKQCLINPKNISLHIPQKRANVDEYPAESSRTAALRIRSEPVQDQNLDIETSTSISVSELTEFPLANETITEVLEAVMEEEIEETSSDEEMTGREEEVKEISTVNRGSILPHCPHCNGTDHCQITSRFCSNNNSSRARGSRNRGRDLNNIARLPAISEPAVDNSGDMDIECQFCGAMIRSSLRSRTFSMCCNKEKHVLPQIEPTPTGIAELLNYRTRDGKKFLENIRSYNSTMSFTSLGAKIDTSVGNNINGAYNFWIHGTICHRIGSILPVTESDVAYLKFAQIYIYDSAAQIDQRQYHSPQLERSVLEKIQSILMETNPFVHLFRTMDQISWEKGQSIDLTLCLVAEGPRDQRRYNAPTASEIAVLIMNNEESTSRDIVLHTRANFQQSINDEDGWTIDASSLSEEHVTHLLHLFGRLFQQYIVDMYAKVEHDRLHFITSNQNRLRVDLYSGIQDAVIHNDCNLANLGKRVILPSSFIGSPRYMAQLYQDSMSIVRRFGKSDLFITFTCNSKWPEITNSLLAGQKANDRPDLCSRAFNMKLKELMIDLTKKIFWGKFWPLYMSLNFKSADFLMPTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NPH9</accession>
    <name>A0A167NPH9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_35995</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294438.1">
        <property type="nucleotide sequence ID" value="XM_018440066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NPH9"/>
    <dbReference type="STRING" id="763407.A0A167NPH9"/>
    <dbReference type="GeneID" id="29000972"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_35995"/>
    <dbReference type="InParanoid" id="A0A167NPH9"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16180">
        <property type="entry name" value="EFh_PEF_Group_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051426">
        <property type="entry name" value="Peflin/Sorcin_CaBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212:SF3">
        <property type="entry name" value="GH27120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212">
        <property type="entry name" value="PEFLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="139"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD76398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="241" mass="27726" checksum="200AC3196304F04E" modified="2016-07-06" version="1">MANPNYNPQYNYNRGSYDYSNNPGGYDRPVPATPRQGGSINRGQQYQNHQNPQNPQSPTYGQRPVSQPPRPAPDNHLIDWFRAVDTDGSGELTVEELQRALVNGDWSPFNIETVRMMVNMFDTDNTGTISFEEFKGLWKYIEDWKRCFQTFDMDGSGSIDRAEMRNALQTFGYNLTDTFVGTLIQKFDRHGLGTVTFDNFVQACVSVKTLTDSFRRFDTDNDGWIYISYEQFLELVISQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NQ33</accession>
    <name>A0A167NQ33_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_180676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294478.1">
        <property type="nucleotide sequence ID" value="XM_018438349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NQ33"/>
    <dbReference type="GeneID" id="28999255"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_180676"/>
    <dbReference type="InParanoid" id="A0A167NQ33"/>
    <dbReference type="OrthoDB" id="5386199at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009724">
        <property type="entry name" value="TMEM70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045325">
        <property type="entry name" value="TMEM70/TMEM186/TMEM223"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06979">
        <property type="entry name" value="TMEM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="21956" checksum="5F63C77B3A58289F" modified="2016-07-06" version="1">MLNCRLQSVRPLTSVLRSRIVHATFGTTRALSTKHEPVTIYEGPLANVAKKLKLFSITSLGLGTGISPFIFMIDVPVPFVAKAALAGAAIVTSAASTGLIQWVMSPYVTKITTTCPEPVPTQLTLHTLNFFAKEHKTTVPTDVLTPSTRIFTSWMVTDPTVAEGMVGNKPAKPKMLFYVHPELCEEPGTMKDIVDQVGIGKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P1X5</accession>
    <name>A0A167P1X5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_180317</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295129.1">
        <property type="nucleotide sequence ID" value="XM_018438295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P1X5"/>
    <dbReference type="STRING" id="763407.A0A167P1X5"/>
    <dbReference type="GeneID" id="28999201"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_180317"/>
    <dbReference type="InParanoid" id="A0A167P1X5"/>
    <dbReference type="OrthoDB" id="1277691at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF32">
        <property type="entry name" value="BAX INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD77089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="249" mass="27244" checksum="D11C206E598A02BB" modified="2016-07-06" version="1">MNPESSKHQQNFSSETTITRPVRHHLLRVYLTIAGMLAIAAYGSHMSVMGMGDSALISMSNSPLSIGVVLGSVFGIRHPSTNNIVRWMLLGAYALFSGLSLSSLIDIFTEWDPSGGLLTAALSSAIFIFFGFSASALFAERRSMIYVGGAAAGLLGVVFWTSLANLFFGNSLVFSVELYLGLIAFCGYVMYDTQMIVEHASAGNFNIPLHALELFMDLFALFTRIAAILADKEKDKKKDKKRKQESFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P4B9</accession>
    <name>A0A167P4B9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_165712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295264.1">
        <property type="nucleotide sequence ID" value="XM_018435286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P4B9"/>
    <dbReference type="STRING" id="763407.A0A167P4B9"/>
    <dbReference type="GeneID" id="28996192"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165712"/>
    <dbReference type="InParanoid" id="A0A167P4B9"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044617">
        <property type="entry name" value="TCHQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45374">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE TCHQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45374:SF1">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE TCHQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="142"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD77224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="29658" checksum="188C21C4518A6F32" modified="2016-07-06" version="1">MPITYKLYVFKLSLWAAVPRLLIAERGLEGIQEIEIDLSKGENYSPEFLAINPHATVPTLEVFRDGVRTDVLTDSISVSEYLNKLSGPKTEVPRPTDQGSKLLQRMHGEADVGNPLFFTSGTREELEFKKSIVVPFLEGRVEAWQEYRTQAPEHGQLYDHNIAQTQQLIGFYNGHADPSPLFAMNANQWKLGAEFLDTVESGLGNQGEYLEGPSYSLVDVHFTPYLFRLVAVKNELVFENRPKLKAYYDRIQARDSFSIFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P877</accession>
    <name>A0A167P877_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_60581</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295489.1">
        <property type="nucleotide sequence ID" value="XM_018440664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P877"/>
    <dbReference type="STRING" id="763407.A0A167P877"/>
    <dbReference type="GeneID" id="29001570"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_60581"/>
    <dbReference type="InParanoid" id="A0A167P877"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD77449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="306" mass="32745" checksum="66314B7AD7390C2B" modified="2016-07-06" version="1">MPPSVLESSPLQTTGPIKFNNVNHQKNNSLNLQDFPNYSDLENANEGGKYNRFLRTIKQWRFQHREFLAEFIGTFILVLLIDGVAAEQTLFGTKSWLTSSFGTGLAVLSGICLSGHISGGHINPAVTLAFWAFSGFPTRKVPVYITAQIAGAFTAAAVLYSVILPAITEFDGGVRQIEGPLSTAGIFATYSPLYVGTGAAVASEVVGTALLLLIIMSSGHPNNLPFVTSQGFVIGIGVIIICLSIGYTSGFSLNPARDIGPRLFTALAGWGFDVFTVHNYYSLVPIFAPLLGAMIGALTFVIFVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P8N1</accession>
    <name>A0A167P8N1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_164386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295514.1">
        <property type="nucleotide sequence ID" value="XM_018434996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P8N1"/>
    <dbReference type="GeneID" id="28995902"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164386"/>
    <dbReference type="InParanoid" id="A0A167P8N1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="167" mass="19584" checksum="B16C7881C8AC5F9F" modified="2016-07-06" version="1">MTLAAHLNYSSFYTRNLRMFRAKTTTESMYKEYKKSGHNIKRNIQSQYFELTSTHAGTTYRKVLNMKRWSQKKQKVLSKPLRNNKAIPNSYLTFWDSFSSKHTVHYETTPLEGYSYCLTPAWDKMAIVYTNSTEERFGSKAKLSIASNTFGFWLYLIALQLFSMCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P8Y4</accession>
    <name>A0A167P8Y4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_4396</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295529.1">
        <property type="nucleotide sequence ID" value="XM_018440185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P8Y4"/>
    <dbReference type="FunCoup" id="A0A167P8Y4">
        <property type="interactions" value="218"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167P8Y4"/>
    <dbReference type="GeneID" id="29001091"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_4396"/>
    <dbReference type="InParanoid" id="A0A167P8Y4"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF730">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="9"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="51"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="93"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="135"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="174"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD77489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="245" mass="26874" checksum="43BE367F683167F3" modified="2016-07-06" version="1" fragment="single">QTKKTNKLFKGHTGPVTSLALSDNGSVLWTGSWDKTIKKWDTNTGECLLTLGGHTDFVKTILLVGDKLYSGSSDNHIFQWDISVEKPICTNVFKGHSRPVESLTLSSDGCFLFSASTDLTIKKWDIEKKSCVHTFLGHETSIYCVKAGDDEIWTASADKSVRRWNTETGAVDTILTHPDRVKSLVLAGPYIITGASDDLIRVWDVASGKLESTIDGHFDEVSALAAVGSTLYSVSLDCSLRRWSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PCQ9</accession>
    <name>A0A167PCQ9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_93970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295719.1">
        <property type="nucleotide sequence ID" value="XM_018443842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PCQ9"/>
    <dbReference type="GeneID" id="29004747"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_93970"/>
    <dbReference type="InParanoid" id="A0A167PCQ9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD77679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="145" mass="15872" checksum="9C1131C53890A1CA" modified="2016-07-06" version="1" fragment="single">LSLFLRLSLSLSIGLSLSFRLSLSFCLSLSFRLSLSFRLSLYVFLSLGLSLSFCLSLSFRLSLSTSFSLLAFLSFSAFLSLYVFLSLGISLFLRLSLSLLAYLSLSASLSLRLSLSWPFSLSPPFSLSIGLSLSLCLSLSMPFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PFD1</accession>
    <name>A0A167PFD1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_60930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295844.1">
        <property type="nucleotide sequence ID" value="XM_018440721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PFD1"/>
    <dbReference type="STRING" id="763407.A0A167PFD1"/>
    <dbReference type="GeneID" id="29001627"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_60930"/>
    <dbReference type="InParanoid" id="A0A167PFD1"/>
    <dbReference type="OrthoDB" id="2287509at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="44166" checksum="CFEBAD8BAFEA4720" modified="2016-07-06" version="1">MENKSTSNKKIERRSSEYSSNYNTELTKLVLVTNDFTAELISSNTNINTAAQFLEFDRMEINRDYQARQEINEKCLVELSEFAASTLNTSRYDIASVYKVIHPTKSPIVSHQLLVQFFLAKIRLTVRLPNHCKEIYDTIQSVNHVESWCPTSLLTLDRLQQKIILLLEVATMWRPRSNLGNLQFQDVHSMVDEKNHLRLRGVPLIARQPKEVCAKISKLGIFADSQACLKSKDMRRHLPEDHRPFLESILGEQSSGRSTYPTTIENWIKKMMIFGLHSLRSASSTKAIIEEASVQEVKLHANWSLNSSTLERYYFRLVYQCACERDIAEKFLGKVTKNKSTSKVGVEPTVLALGTIHNGNIGETKTEDVVPTCPNSNWKKFLNSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PFK0</accession>
    <name>A0A167PFK0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_141678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295857.1">
        <property type="nucleotide sequence ID" value="XM_018430642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PFK0"/>
    <dbReference type="GeneID" id="28991548"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141678"/>
    <dbReference type="InParanoid" id="A0A167PFK0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="161" mass="18317" checksum="543F46C2F5E53282" modified="2016-07-06" version="1">MHARKYIENYGIWFEISMGFSQGWLSMTRPMLSSNLSTTPQQHIFFLLPKLSRLMMMILMYMLLEQGCLCTADRITTLGTNNLIVLSSSLTARFPKNVPGPKCIKYNLQNGSAIEQNILRDLGNKSRLDLPSSGLNDQTLPNFRDFFLFLLLFSLEDLAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PPE2</accession>
    <name>A0A167PPE2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Actin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_179515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the actin family. ARP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296338.1">
        <property type="nucleotide sequence ID" value="XM_018438158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PPE2"/>
    <dbReference type="STRING" id="763407.A0A167PPE2"/>
    <dbReference type="GeneID" id="28999064"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179515"/>
    <dbReference type="InParanoid" id="A0A167PPE2"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10216">
        <property type="entry name" value="ASKHA_NBD_Arp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000205">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000015">
        <property type="entry name" value="Actin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000018">
        <property type="entry name" value="Actin-like protein (Centractin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD78298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="42274" checksum="BE0B898A736A2973" modified="2016-07-06" version="1">MNSEFDDVLTNQPVVIDNGSGVIKAGFAGEEQPKCFFPSFVGHPKHVRIMAGAVEGDTFIGRKAQELRGLLKIKYPIEHGIVTDWEDMESIWQYIYTDELKTLSEEHPVLLTEAPLNPRANRDTAAQIFFDTFNVPALFTSIQAVLSLYSSGRTTGIVLDSGDGVTHAVPVYEGFAIPHAIRRIDIAGRDVTEYLQLLLRKSGYNFHTTAEKEVVRIIKEKTCYIALNPVKEEKETSGKMDDFQLPDGNIIKLGAERFRAPEILFQPELIGEEYPGIHQVIVDCISRADLDLRKSLYSNVVLSGGSTLCKGFGERLLSEIKRLALKDSKIKIYAPPERKYSTWIGGSILASLSTFKKMWVSAEEYQEDPDIIHKKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PVA2</accession>
    <name>A0A167PVA2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_163698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296637.1">
        <property type="nucleotide sequence ID" value="XM_018434857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PVA2"/>
    <dbReference type="GeneID" id="28995763"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_163698"/>
    <dbReference type="InParanoid" id="A0A167PVA2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="433" mass="50604" checksum="ED8E61113E0FD5EB" modified="2016-07-06" version="1">MENANAFKKYNSSIDSLDKKSVYLNNSKIVNNEARNIHEIFSLCFPPLLNHYYKEKQLAVVYHDLQIPSEECLNKYNDELKIKETIDVRFDTYISNAYAMYLYVFSNETCISILSSCFDTSAIHGSVLQSISINIDASLKILIGHAILEFCFKYLFNRAENIFNDFVCAYRNLWVGVSKVDALDYSSINFYLYQTTKVRMIEIRISQLENKTMSLHYDLYLEVNNEAVISLFVFFFECFIGILDFVPAHQNAGIISIIWNRCTATKECLKALLTLDKAAESEVGELIDREIKNICDFCEEIIKRKAKNNKGSTDRLKTVLTTLSTFVWTNIALKWDLYTIYLYMPYKYTYFQRIVYRTLTPKSKIYISYVESNIYVNNTTPCLKVSDCNKFLVRYLISFSRSSIKIRNIFSKNNRIIGHKDKYFTELFADIWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q1N7</accession>
    <name>A0A167Q1N7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Type 1 phosphatases regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_164012</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the YPI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296956.1">
        <property type="nucleotide sequence ID" value="XM_018434919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q1N7"/>
    <dbReference type="FunCoup" id="A0A167Q1N7">
        <property type="interactions" value="207"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167Q1N7"/>
    <dbReference type="GeneID" id="28995825"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164012"/>
    <dbReference type="InParanoid" id="A0A167Q1N7"/>
    <dbReference type="OrthoDB" id="307488at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD78916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="160" mass="17717" checksum="6E195B6C7D6D00A7" modified="2016-07-06" version="1">MAIEGQYNTNNGGSSTRMRDNLAGPSHGSRTLTVEETYESDQDNVASNGSEEEVGVLRLRGDMTVRRPRAIQWDENVVDNEHLGRKKSKICCIYHRPRAVGESSDSESSSDSGSGSSSGESSNNDRARPCNHSHHRRNKKKNPRQVSPNAYEKQPVYKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q757</accession>
    <name>A0A167Q757_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_154088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297236.1">
        <property type="nucleotide sequence ID" value="XM_018433296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q757"/>
    <dbReference type="FunCoup" id="A0A167Q757">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167Q757"/>
    <dbReference type="GeneID" id="28994202"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_154088"/>
    <dbReference type="InParanoid" id="A0A167Q757"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATOR SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="359"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD79196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="43019" checksum="BE1C10944150B324" modified="2016-07-06" version="1">MMNLSIAGSTSNNDQLLDHSHLKPGSKASLLSYNQTINMYRENAKKTNSPDIQCDFAIFMVEAAKSIVDDDTTRSEYLAEAEKLLKQLSARGHAESQYYLGNLYASGLLSKKGKNDFDKAFPLFVQASKHSHADAAFRTAKCYEDSLGCRKDSSKALQFYRKAAALSHPGAMYRLGLAEINGELGISKNPRDGVKWLKRAEEGATSEYPHAIHELGQLHEKGIPNIVFVDLDYAVSLYAQGAELGYAPSAFRLGECYEYGKLNCKQDPALSIHYYTIAAQQGHREACFALTAWYLVGSPHVLPQSDEEAYLWAKRAAEKELPKAEYAVGYFTESGIGTQKNPVEAMEWYKKAAEHGDKRAIQRLQGKPSDQKTSKKKDGKDEDCTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q8R3</accession>
    <name>A0A167Q8R3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7905 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_157200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297319.1">
        <property type="nucleotide sequence ID" value="XM_018433583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q8R3"/>
    <dbReference type="STRING" id="763407.A0A167Q8R3"/>
    <dbReference type="GeneID" id="28994489"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157200"/>
    <dbReference type="InParanoid" id="A0A167Q8R3"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057227">
        <property type="entry name" value="DUF7905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25482">
        <property type="entry name" value="DUF7905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7905" evidence="1">
        <location>
            <begin position="7"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="188" mass="21900" checksum="18B72BB9070A2BED" modified="2016-07-06" version="1">MTQGVVQLDKVVTRNNPVTEINWISLDRIFDFQMSLKTQEVVRSDVKPYTTFIKRVAATLTSNTLTYEDVPDFLKVQDVLHKHTTRHRLHYPFIIEITRTQRLTRTPQPTMGITSQKIMCAYTGLDMWYDVEVFYSPHKAEFELNRKLAVGKLAPWTVETILGENDSQLIEYVRCLLLLTEKYQSVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QEP9</accession>
    <name>A0A167QEP9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C3HC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_75569</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297631.1">
        <property type="nucleotide sequence ID" value="XM_018443073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QEP9"/>
    <dbReference type="STRING" id="763407.A0A167QEP9"/>
    <dbReference type="GeneID" id="29003979"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_75569"/>
    <dbReference type="InParanoid" id="A0A167QEP9"/>
    <dbReference type="OrthoDB" id="2592092at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013909">
        <property type="entry name" value="NuBaID_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012935">
        <property type="entry name" value="NuBaID_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835">
        <property type="entry name" value="NUCLEAR-INTERACTING PARTNER OF ALK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835:SF6">
        <property type="entry name" value="ZINC FINGER C3HC-TYPE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08600">
        <property type="entry name" value="NuBaID_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07967">
        <property type="entry name" value="zf-C3HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3HC-type" evidence="7">
        <location>
            <begin position="68"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="NuBaID C-terminal" evidence="8">
        <location>
            <begin position="241"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD79591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="42428" checksum="86962BB0293C76D1" modified="2016-07-06" version="1">MINITTTTTTPTNNALEIANEILELMSKVRKELNLLPPLNGIKRKLPDEDEDVHKRVKLSPSDVNRIYDRNEFLGRLKTYPGIYIYSRRPVSAVACAKNGWYYEKTVESLDNDVGLLSCKDCKGTLAVIDLSPHDPSNPQINKIITIYEEGLKAYHKEGCFWEFSQCNDYVNSFPISTYKEALELVCTQGKLLYSQQHILPNIVDPLDKYQRRAVNQVAQHYEHNKDEAMAIVTDSSLITAYTLPLYGWKLKSTEVPYLQCDSCFQRYSLSQENKSDQFDVIKEHRPNCPWVSSTDALIYRPGSQQGLMNGYGWMLGFVNKEHLLLLEALESNRTALQHLSDKKDALRKKLEEDTKRILLAASKPFTPSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QPB6</accession>
    <name>A0A167QPB6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcium-binding protein NCS-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_130375</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298047.1">
        <property type="nucleotide sequence ID" value="XM_018429354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QPB6"/>
    <dbReference type="FunCoup" id="A0A167QPB6">
        <property type="interactions" value="138"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QPB6"/>
    <dbReference type="GeneID" id="28990260"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_130375"/>
    <dbReference type="InParanoid" id="A0A167QPB6"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD80007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="190" mass="22083" checksum="2666E2766D62C188" modified="2016-07-06" version="1">MGKAQSKLSPEQLGDLQKCTYFDKKELQQWYKGFLKDCPSGQLDKTEFQKIYKQFFPFGDPSRFADYVFNVFDNDKNGTIDFKEFICALSITSRGQIDEKLFWAFQLYDIDNDGFITYDEMLHIVDAIYKMVGSMVKLPPDEATPELRVKKIFDLMDLDKDGRLSKEEFREGSKKDPTIVQALNLYDGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QX67</accession>
    <name>A0A167QX67_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_178583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298457.1">
        <property type="nucleotide sequence ID" value="XM_018438011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QX67"/>
    <dbReference type="GeneID" id="28998917"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_178583"/>
    <dbReference type="InParanoid" id="A0A167QX67"/>
    <dbReference type="OrthoDB" id="2281185at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="161" mass="18590" checksum="1AE8D55BC29D5613" modified="2016-07-06" version="1">MLEKTINIIVDQYVHINLMRAKGLSFLRAARKDNDGKILYQEYRVKYYKPKLADEHHKSQKSYKKDNSNHICLTLYTLLSIHFNSNYHTMDPGYSLLQHIKTIPNLINEDPSMVTPENTSFKDVPWCDLAYLSNQRSFLNKSAFPSASSSDSSVLDEPSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167RBB9</accession>
    <name>A0A167RBB9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_161892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299317.1">
        <property type="nucleotide sequence ID" value="XM_018434519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167RBB9"/>
    <dbReference type="GeneID" id="28995425"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161892"/>
    <dbReference type="InParanoid" id="A0A167RBB9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="114" mass="12914" checksum="D0E27ADF4A8B000F" modified="2016-07-06" version="1">MGNLTDKYKINVGNKEVYKIRGKWYNVFRVLGARFPKEPGGTTLVPRDTSFGQLTIDVDAHESGTARHSSPPDQTTEGIHRPVFLTRNWPKPHIFTKHVTEQLRRNSSAGRALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167RE92</accession>
    <name>A0A167RE92_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_178942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299489.1">
        <property type="nucleotide sequence ID" value="XM_018438062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167RE92"/>
    <dbReference type="GeneID" id="28998968"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_178942"/>
    <dbReference type="InParanoid" id="A0A167RE92"/>
    <dbReference type="OrthoDB" id="2269082at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD81449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="110" mass="12635" checksum="05C02F9F20BCD47F" modified="2016-07-06" version="1">MFVLAGVYRQKTISSCADRQGRTEEEEGCATAILVAYFLLGTCFVIWTSLQIYFGLVIQAYLLKTEGRQRYSALKDQFIRDWDAQMEATNNGISRMNTVSNYNKMKNVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167RFS4</accession>
    <name>A0A167RFS4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type zinc finger transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_162149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299589.1">
        <property type="nucleotide sequence ID" value="XM_018434570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167RFS4"/>
    <dbReference type="GeneID" id="28995476"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162149"/>
    <dbReference type="InParanoid" id="A0A167RFS4"/>
    <dbReference type="OrthoDB" id="2275825at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD81549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="988" mass="109376" checksum="DEE5507DD6368818" modified="2016-07-06" version="1">MQLFLKGTANHSAVIDITALTVTQKPLFLSDLQTFFNGNEHLWAVTDQIHREYNRLYAEIVVSPLYYNRSKNDPVLILPSFDVPFAIYPTLPPSAKILKISLSRLAQLHADMTNNFSQFGAIVDCGYVTGSSGLYAGGGYAVLALSPPNSTHSSVKLSHSLNWSYQPLNYSSDTGTLSSDFDHVSIFATWAAMPPFCRYCHLDKHALIDCDLRKKATMCCLCNDGGHIAKSCPRKNESSVTPQKHRKIPAVQETPQPSTPSSSIVVPPLPSSSSTNVPTTTGRVKRIQGSLERSVTCSQASLVVPNAPHNPNPIKEHKLPLPYLLALQETHATSTLQDTFHSQFQAKTRFWSVHCGLVSFSSDIILSNSFTSPCGRIISSTVSHTNSPSCPLSALNFHPYFLPLHAVQSYWVISTTLILLLPQGFGRRLTIGSSTSMSSLLMGSPHLNRFPIRLSIEDYPNRVLIICLSPLIWLLPSTLITVEQLMSNQLGLIIFYCLLNYNYPQPRMLPCRSMWSERGCGVPTLGCCVHNFAPGLYPATKWEALKATTAKVARAFSQHHAFTLSHAEDLLHRKHVGITKKLVTDPSLLPVLSPQLLIVEHQLSQLQQYHVEYLALRSGLRWCELGESSSGYLKQSIASWASQKMIPPLWNPATSSICTSQEEMLETTTQFYSDLYSPNDVDQAAIDNLLNVLPTHIHISSSAAESLVAPITYNDLLDAFSQSPQKSSSGMDSLPYELVRLVVTDLACHDIAVELACHALRADLVCCIQNCNKVLYNCVGLVPSSQLLHRKYGLVGPFHVPLSFPVCFPFYSTISNITAMAMAVTPKIWITSCSSCSHNVVLSYSELDKAPCPYSFMPWNNCHIHLWECIVYPTLSRKVQALVSDRDTTVSSFFTHVFTAPSSGTFITPSPTAIFDHTFINLALTSLVLPDKSCPNAMFAIAAALEAIWRSHWAFIFNDTPFHASQVEYLIDKLFLKARQESFLTGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N3P2</accession>
    <name>A0A162N3P2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_183194</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286268.1">
        <property type="nucleotide sequence ID" value="XM_018438733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N3P2"/>
    <dbReference type="FunCoup" id="A0A162N3P2">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162N3P2"/>
    <dbReference type="GeneID" id="28999639"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_183194"/>
    <dbReference type="InParanoid" id="A0A162N3P2"/>
    <dbReference type="OrthoDB" id="2420415at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025305">
        <property type="entry name" value="UCH_repeat_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13446">
        <property type="entry name" value="RPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="424"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="561"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="726"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1057"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="583"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="746"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD68228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1190" mass="133582" checksum="23529F05236B4A8C" modified="2016-07-06" version="1">MSDGPPIPPRAKLVVGDLLPPDAFTPAALLEWLLHYTTTSNHQHNFTLLYNPEVDLHSKTYVCMTCHYGIELLAETPRFCTANQYQTHHYHYKTDHYQCCGCSYTIQATFNPPLVSLDLLGRLAATRPNYQTLADRISQPDKILPTLETTFTAALQFTKDLIKGSRRDINSRNVNLEIKLGVDPASIELLNLLGFELKDSFFIAPSEAYVTVNKDRLLRIQHELALFLESCRSPTNNTALDISSANPLIAEWVGVNEILEPTTGRQVETFRLFGTIPTAKDDLVIWLYQMVLKEHPNDSAMYLDCLIDAANLSRSNLLLTEVALERSRGKVGYKEIREACENFDIKQDVAVDDRLLTELYRIKVSDEPHNKNKHRDHLKVIAIARRSEALYDFLKDEVPDMPKLIHQDGTATQDWNTNSEEIPVGLNNIGNTCYFNSLLQYYFTLLPLRKTVLNIDSYVENEDDPNWVPKKIGGITVDQHEVRRAKKFVYLLRSLFINLQNTSQRAISPEYDLAYMALLNEKDVEEAAAEAAAEAVASVSASAVEASSTPIESLQTIDQQNVAGPSNSQHSPPLVDLSDPRTDSSFPNTDMSPQEENTTTTTGTGSKQNLGPLFKAKKDVDNFEPAAKVEVTSAAKFEDITGRDNNAEQTTKSIPVSEANVFNSIPKHTIAADALEAPRTKPAFSDTRSVTTTSLVKIDEDTISGSMSHIEQVVNKDQPVPVGVPYPEAEPADNTAPALVPDSALAPNQGSGTKPFQSSDSLNESQILSQPNRVGVDTLLEGYTEPGLEATPMDVIDEAYPIEKIDTSLPEFDMPPAYEDLVGTPAPQNNKVPPPITAKRPPPNPATMMFGKQQDVTECMDNVTYLIEAALKPVETQDGEQVRDMVRDLFYGKARQILTYQDTQTSQNIKKIKEEEFSHLIVDAAQGKDLYDGLDEYFFADQVENFQGGREATREVTVSTFPPVLQIIVQRVQFDRATANVYKSNAFIQFEKIIYLDRYADRNFDSLAEKRAEVTNWRKEEEIHKAKIDELINNKANMLEATANILEIQMAQQPQNAEQHEAAIQFLLKEAREARETIQESTCAIEVLRSKIKNQYSSLTKDAYRIHAVFIHQGQANYGHYWVYMYDKPTDQWWKYNDSHVTKVEEAELFRDTSGSTANPYFLVYVREEDSDALVETVAKKEIPHVLSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N7S4</accession>
    <name>A0A162N7S4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_148500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288619.1">
        <property type="nucleotide sequence ID" value="XM_018432102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N7S4"/>
    <dbReference type="STRING" id="763407.A0A162N7S4"/>
    <dbReference type="GeneID" id="28993008"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148500"/>
    <dbReference type="InParanoid" id="A0A162N7S4"/>
    <dbReference type="OrthoDB" id="2279134at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="34995" checksum="EDC5981047634E61" modified="2016-07-06" version="1">MSSTEKHCASCKLMGHSRKSSVLYPLYKKQNTLYIPQKRTNENISIEEEFPAKTASSRVKINPVKEQQIIVDTVVDPTIILAEEPTIEHEEETMTINESTATRHCPSCLRTNHLRITSLMCPNNVQILVQNQNPQNQNVANIARLQNISEPEIDSRGNMDVVCRFCGALMWLKEKDTDLSIRRSKFNMCCGKGKYVLPSLEPTPPGISELLNYRTSNGKNFLSKIRGYNSTLSFTSLGAKIDNSVANNQGGAYCFRIHGTICHRIGSIRPSRAQDIDHPQLAQVYIHDPASQAQHHCHHAPYLKADILEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NEG7</accession>
    <name>A0A162NEG7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_158964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291608.1">
        <property type="nucleotide sequence ID" value="XM_018433886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NEG7"/>
    <dbReference type="GeneID" id="28994792"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_158964"/>
    <dbReference type="InParanoid" id="A0A162NEG7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="64" mass="6998" checksum="4260A78CE3B786CE" modified="2016-07-06" version="1">MNGFILCATFDIFVLVLVCPKKELNIVVGGVNLDRVLKLMLKYVMVAGVSFDSVVKLVSIPVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NF43</accession>
    <name>A0A162NF43_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_150012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD69014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287054.1">
        <property type="nucleotide sequence ID" value="XM_018432380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NF43"/>
    <dbReference type="GeneID" id="28993286"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_150012"/>
    <dbReference type="InParanoid" id="A0A162NF43"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="90" mass="10164" checksum="729EE2420F8B152E" modified="2016-07-06" version="1">MVLEDNSLEPDDDAIEFATYVESDDDDEDPFFMPEHTKKSSTLSFNNLTCSPVQVLRFTVPTVCIIIIITYTIVIAVLTHKRRLPGQSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NHY5</accession>
    <name>A0A162NHY5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_67645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292468.1">
        <property type="nucleotide sequence ID" value="XM_018441830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NHY5"/>
    <dbReference type="STRING" id="763407.A0A162NHY5"/>
    <dbReference type="GeneID" id="29002736"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_67645"/>
    <dbReference type="InParanoid" id="A0A162NHY5"/>
    <dbReference type="OrthoDB" id="2368002at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="220"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD74428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="540" mass="60667" checksum="6A877DB7D0C1D90B" modified="2016-07-06" version="1">MVRLEEAPFNRDIPTQSNWLQPNNHSHDTDNADGSTKKKSMDRISRLFQKKPKKKQPPASLTTSFSNLSLASSELSPVSDVQPSIDSLSMRRGVSGQINQNYYPQPSQSYENQKTLPPLPQNEKGIKPESGTLDTVSTAPSLSNTTSTHHLGTEQWQSPATTGQTSSLIRALSTRSNNQHHLTPLPDKNLSGISGQDSLRSMQSIARSLSNSSYTDHTSVSALKARLEKQRFVLEKLELEKHQYEQDNIHLNDQLSQLNRKSDQRDTDMGQLKVNYDIHLCSMRATEDDLDTIAAKVRLLKESISQLAGELMEHADPVIATNALYTFWLNLSTSIDELKEGPDQTLPLHRMRMLTEKFIMDVLIQNLNVSFFPGLSTAATSAYNELCTFFRQHDREFATRLRQELALVVVKNKGQKETIDKELHDILQSNWKYLYGGLSKAYPFLYQHDKIEPDVRKHYGAKIQKLVEQAVTLGCAIKGQEIVITGADVREGTQIFDSNFMVDEDGQTSGVVAFCICPPFVVLCEPYRCLEAGKVLCKPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PU29</accession>
    <name>A0A162PU29_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_165961</name>
        <name evidence="2" type="ORF">PHYBLDRAFT_175949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441009">
        <property type="protein sequence ID" value="OAD65561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283601.1">
        <property type="nucleotide sequence ID" value="XM_018437609.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294027.1">
        <property type="nucleotide sequence ID" value="XM_018435335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PU29"/>
    <dbReference type="GeneID" id="28996241"/>
    <dbReference type="GeneID" id="28998515"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165961"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175949"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD75987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="49465" checksum="6A7BBCBC1482F9ED" modified="2016-07-06" version="1">MEKRNKAWVDFYKQASLLKKFLRGRIEDLRLETKIRENLYRFCLLRKDFVSKFDQVPKLNYYCYLYYFGLENYMTGISPNEVLTSKKMTKCIPTAPRRPNLRINAVLNSTNAGVVVPIDTPTPEVAVDIASEVQVAVTPMDHVLTLLAANNVLMQSLQQNAKGVTDAITHLKNGLDLSNKTNEFLKNSAMTSQNSVMPSAVPADSSSSMDDDLDLGAKHHPLISQLINSYIKKPNFVSTDPLKVAENNNRSAWSMTGMYGNKYNKTLALALFKYLRPQRCCTNVSKSIIINIIKNHYQNQVRVFRTSAEKIMARNKAGRRHNRKKTLLDHCIITYQTYTEAIHEGMNRYDCRNILSIEMMSEGKSDGDNKVWAYRPSWRTDELQTFISIIDELTVIHLKKNSESLKKRIPYEKEVSIPENLAVTLPDWCFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PUG5</accession>
    <name>A0A162PUG5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_63943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292146.1">
        <property type="nucleotide sequence ID" value="XM_018441206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PUG5"/>
    <dbReference type="GeneID" id="29002112"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63943"/>
    <dbReference type="InParanoid" id="A0A162PUG5"/>
    <dbReference type="OrthoDB" id="2285904at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="271" mass="31270" checksum="87638C3654DF9DE1" modified="2016-07-06" version="1">MRSHMEHHPGIKNVEEWKFVSQNLDKIAEAAIGSIVKDIAKEYSYANPPNKQPLQNGSPSYYSMVTSTYYTRCLSALVNMTISELRTSDFFFDNNDIKIKKVHGFNLSEFLPFVIATEPKHTTQPLDKNLIGSKRFDTDFKCLFTSQNLQKISQMLNDRQEVSAEHKLVVQNLNIAEEQQVFLEDESTLDYDVPERRLNQLESIIKHLVFSNYTPIYLEDVRHQSPETSTAEQSVCSLICSTLKKSLPPKKQYHVIAYQIYFCIFANDVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PUS4</accession>
    <name>A0A162PUS4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphotransferase</fullName>
            <ecNumber evidence="11">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_144663</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292246.1">
        <property type="nucleotide sequence ID" value="XM_018431265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PUS4"/>
    <dbReference type="FunCoup" id="A0A162PUS4">
        <property type="interactions" value="299"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162PUS4"/>
    <dbReference type="GeneID" id="28992171"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144663"/>
    <dbReference type="InParanoid" id="A0A162PUS4"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000020">
        <property type="entry name" value="Hexokinase-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="12">
        <location>
            <begin position="18"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="13">
        <location>
            <begin position="219"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD74206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="457" mass="51203" checksum="A1F744814ED0CB7A" modified="2016-07-06" version="1">MSLESPSIEPNKAIQLAIDELKSQFELPFETLQHIVSNMRKEMSNGLKSDNTNIAMLPSWITRHPTGQESGEYLGLELNATYVRVYLVNLHGQGQITTRQQKYFLEESLKRGSINNMIDFLATSVDHFLTFIGKCRITEPIALGFVLSFPLHHSALNKAHVIQWTKDFEITGADGKNIAELLQTGFRRRHIPVSVKAVINGSVGCLLAHSYRSLDTLLSCTISTGTNAAYWEKVKNVVKCKGADENDDMIVNTEWGSFGDRNPDYLPRTYYDNHVNRRSVNPGVHTYEKMVSGLYLGEIARNIMMDFVDRRLLFNSQYTQEMNSHYGFETSYMSAITADKTINLEETKHILESIMNVPCTTLCDRQLVKLICDLVAQRAARLVASGISAIINSSQEVERGLTISVEGTVYEEFPEFPRMVNEALREFYGSNADYINIGITRDGNGIGAALAAMIGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PWI0</accession>
    <name>A0A162PWI0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_180168</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294687.1">
        <property type="nucleotide sequence ID" value="XM_018438273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PWI0"/>
    <dbReference type="FunCoup" id="A0A162PWI0">
        <property type="interactions" value="742"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162PWI0"/>
    <dbReference type="GeneID" id="28999179"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_180168"/>
    <dbReference type="InParanoid" id="A0A162PWI0"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23813">
        <property type="entry name" value="UBCc_UBE2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000020">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD76647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="149" mass="17014" checksum="F62035739A7AE415" modified="2016-07-06" version="1">MALPRRIVKETERLLADPAPEISATPHDDNLRYFDVIIAGPTQSPFEGGVFRLELYLPEDYPMAPPKVRFLTKIYHPNIDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDPLANDVAQHWKENEKDAISTAHEWTRMYAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PWS2</accession>
    <name>A0A162PWS2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_111325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292916.1">
        <property type="nucleotide sequence ID" value="XM_018428207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PWS2"/>
    <dbReference type="FunCoup" id="A0A162PWS2">
        <property type="interactions" value="230"/>
    </dbReference>
    <dbReference type="GeneID" id="28989113"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_111325"/>
    <dbReference type="InParanoid" id="A0A162PWS2"/>
    <dbReference type="OrthoDB" id="2446582at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="103"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD74876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="221" mass="25801" checksum="26B7E7C65718A93F" modified="2016-07-06" version="1" fragment="single">KLNKTKATIFAERIGVKDFNASQVRMEKFGKCYDIKMNQIHDKAGLTDIELLQIDKTAIKEKIEVYSACDIYKFDETVLFYAAPPRKTISYQKFSGWKGNKKWLTVNLLCNANGTDKWSDILIISHARRQNCFNKNNKKQEAVDHRFFMYHYNNNAWMTRSIFHVFFHHFDHSMKAQNCKVLLILDNFSGHKVNYVPTNVELLFLSPNTTSHLQPLDGDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PX49</accession>
    <name>A0A162PX49_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_167331</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60324"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:15536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.359"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293046.1">
        <property type="nucleotide sequence ID" value="XM_018435627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PX49"/>
    <dbReference type="STRING" id="763407.A0A162PX49"/>
    <dbReference type="GeneID" id="28996533"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167331"/>
    <dbReference type="InParanoid" id="A0A162PX49"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140955">
        <property type="term" value="F:histone H3K36 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.100">
        <property type="entry name" value="Set2, Rpb1 interacting domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042294">
        <property type="entry name" value="SETD2_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038190">
        <property type="entry name" value="SRI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46711">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46711:SF1">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Post-SET" evidence="6">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS N-terminal" evidence="7">
        <location>
            <begin position="139"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="5">
        <location>
            <begin position="398"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="455"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="588"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="706"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="758"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="706"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="771"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="785"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00030091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD75006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="797" mass="91944" checksum="F80333012B2C600A" modified="2016-07-06" version="1">MQSIMKAKTDKDMSSAVAQKCYCGMPNCKGFIGASDKKSDEFEESEVSPSEEEIEEEEEESDSTESSWPKKKNLKRHRRRHSEPLQDPDEVQTFVKKMLDSVGKAHLVNKLLRRLELTNPNTSRGKEVLKQFLWLHGLKMLKFWLGEWKNDEDIVKKVLHVLDQLPLANRNGLEDCKMIDVVRKLTNHEDEEISEMAEALIEKWENLKSIYRIPKRMYVEPQPAHKETFEERMGLSQDEEDSDYGSYLLRTNKRARYSSTREFFDPDDDYFEYLSMYATPEEIHWKLQYPPVPIIPTAPRAMLDYAPSLSHKYYNRPTETDSPTQPEPNRYLYSEMNGNSGVENDAFDTGFSLSESDSRLIDSMNNNSLQSSGYYDNPSQTTPSQMHIVSTPSPVAASKLPLNWRMATCEDGTVYYYSKITGKSQWDFPEERVSSIEGVDQAQLTGLVERAIMDAQKKKNGNTSSESPASRTDRSPRLTTPSTSTDATPLGDSAGFDEAEIKKEVGKVVTKYLSTRQSALWHGDRHLFKELARKITHHIVDRESNSSKKFQGMDLSRRLKIEKFIDTHGPSFAARISKKKRLFVDSPLNHSVDDKSDSRATSVSLDTLREPEEEEEEDKIPKKVEDEPAQITPESMVKEVDNINEPRDSWVPNRELDQRRENIISTSLSPAFNMLDIGSEVAATRNDASRPASHRASDYYYYNRRSRDESPYGRDRSYRSHDLGSDRYLPDYPRSASTFRPPGNYYYSSYYRHPPSPPPYRFHRYYGGRQSPPYYRSSASSSRRGSPDEDFDRRRWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q7H6</accession>
    <name>A0A162Q7H6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_161405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298806.1">
        <property type="nucleotide sequence ID" value="XM_018434395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q7H6"/>
    <dbReference type="GeneID" id="28995301"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161405"/>
    <dbReference type="InParanoid" id="A0A162Q7H6"/>
    <dbReference type="OrthoDB" id="10349338at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="678" mass="79855" checksum="51F7A3F58CC59EC9" modified="2016-07-06" version="1">MLVSELPFEILANIAAFSSQETKLQCTVICKAWQIPFQDSLWDTVKITDNKDDGNSVLDRITDLSKLYKKNGHRVRSLILYMDSYICGSQLQTAQEYFQRIKHLSIQQKTLHWRVSGNFTNWRAWRSLTHLEIEISKLNHGRKMDKTFEILSFLPQLTSLHIIDSGQTSQYRFTWRTMDFLHGCLPRLQTLQTKIPLIDIPIHQIKQMTNIVPAETITKVNLSLKYSSFGWVYYSNLKYPNIHTLGLLTRRQMDDYEEDSMSTSRLSNDEDMSDDDNDMIYSDDDGDQDTSEDDIEDENISDDEISDYTLEDVTKMFSTLPYFFPSLKKLEMNKNLMSKGEHDLFWKLIRKFGVSLKYLNHKCCSILMDMHNPETTVIDYVEAFSLNIETLYYQVDPNPMMQQPNMTAHPMLIHYYLYLTELNIRLYTEDMALDVLLNHCYSLKRLFLSVNELTICEDAAYRLDPHNLERLELYGVKARTSLFNYLSVRCENLTHMVFCNVRIFGPISQETGNICLDMRYTRFKVLRLGNVRFYSERDLGLAEYEYKDRMIHLITIEQIESMHNKTSPSNSLLQVPKAPTIEQLWFLYFKDKKRREGCFIAQKLNRSQARLIQDYFRMFERINKRPCDHKGNKYSKDEPEENCYWADHPPRGYVTLRCGYVANYSGKSIFESKFVTCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T3T4</accession>
    <name>A0A162T3T4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative lipoate-protein ligase A</fullName>
            <ecNumber evidence="5">6.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_175577</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysyl-[lipoyl-carrier protein] + (R)-lipoate + ATP = N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10500"/>
            <dbReference type="Rhea" id="RHEA-COMP:10502"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LplA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.20" evidence="5"/>
    <dbReference type="EMBL" id="KV441006">
        <property type="protein sequence ID" value="OAD66052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284092.1">
        <property type="nucleotide sequence ID" value="XM_018437521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T3T4"/>
    <dbReference type="FunCoup" id="A0A162T3T4">
        <property type="interactions" value="322"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162T3T4"/>
    <dbReference type="GeneID" id="28998427"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175577"/>
    <dbReference type="InParanoid" id="A0A162T3T4"/>
    <dbReference type="OrthoDB" id="201621at2759"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00594"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016979">
        <property type="term" value="F:lipoate-protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16443">
        <property type="entry name" value="LplA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019491">
        <property type="entry name" value="Lipoate_protein_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00545">
        <property type="entry name" value="lipoyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10437">
        <property type="entry name" value="Lip_prot_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="11">
        <location>
            <begin position="58"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD66052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="376" mass="42529" checksum="EFA2D91443475658" modified="2016-07-06" version="1">MLWNSSLRLQGISKTFKSISCYSTAAQFNTSKVDCYISTINNCYTNLAIEEWLLRETDPQRHVLYLWRNKPCVVIGRNQNPFQECNLEFMRQNNIPLVRRRSGGGAVYHDMGNSIYTIYMPRHAFSRRTNADLVSRALQQLDVPAYVNDRHDIVVDGLKVSGSAYKIINQRAYHHGTMLIDADTEALKGCLSKKRMNKTGIISKGVESVPSPVTNIRDYSFTVDHQQFCESVLAEFIHDYNDGASIEPIIFDEEHIEQLPSKVKETAKELQTWDWMYGQTPEFTNTIKNEFDWGHVNGSIHSKHGMITDAEFSTNSAGAHEVTVVSAISVGLKGCRYSPNAVKEAAAKITSEIPGLISAENEHLVEDMDRWLSNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TFI0</accession>
    <name>A0A162TFI0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_137228</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="KV441001">
        <property type="protein sequence ID" value="OAD66723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284763.1">
        <property type="nucleotide sequence ID" value="XM_018429845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TFI0"/>
    <dbReference type="FunCoup" id="A0A162TFI0">
        <property type="interactions" value="372"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TFI0"/>
    <dbReference type="GeneID" id="28990751"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_137228"/>
    <dbReference type="InParanoid" id="A0A162TFI0"/>
    <dbReference type="OrthoDB" id="15318at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1500.10:FF:000002">
        <property type="entry name" value="oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000166">
        <property type="entry name" value="Coproporphyri_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD66723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="339" mass="38755" checksum="839F5A4AB80CB26B" modified="2016-07-06" version="1">MVSNTCIQSISRQDTLRRSSGEPLTNKDPIRLRHEAFVKNLQNSIVKAIEQVDGGKFERTSWQRAEHGGEGITCVLQDGAVIEKAGVAVSVVYSELSDTAIQQMRQDRGKSLEGQGPFPYFVTGISLVMHGKNPHCPTVHMNYRYFEVMNPDGSTKLWWFGGGADLTPVYLYEEDAVHFHAVHKAACDKHDLAYYPKFKPWCDTYFKNAHRGEGRGVGGIFFDDLADKPAEQIFAFVQDCGNSFVDAYVPILKKRKDHAYDDEQVRWQQIRRGRYVEFNLIWDRGTRFGLHTPCARVESILMTLPLTVRWEYMHEPKEGSIEARLEQVLKTPVDWIPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TFK8</accession>
    <name>A0A162TFK8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type zinc finger transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_174780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441000">
        <property type="protein sequence ID" value="OAD66743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284783.1">
        <property type="nucleotide sequence ID" value="XM_018437337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TFK8"/>
    <dbReference type="GeneID" id="28998243"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174780"/>
    <dbReference type="InParanoid" id="A0A162TFK8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27747" checksum="6358DCCC71C1B37C" modified="2016-07-06" version="1">MSSNSILDSYQCNQCKERHTNLKKPKSCRAQCFKNRHRRHNDIQTSQTTPVPGQVSVVLNTVSNDTIDRERADAIEDQIMDTLNSKDNDDPIINIFSNDDNDESMYDAELGNDMDIIENETSPLVFDFSQPAPTPDKDDAKNLEFLKIIKDFGISRNAHEMIVKHFNSILETSTCITYRACTPHLGKKLLKRFSGVEETVHDICQRGCMLFTSPSQTECSNCGQSRAIFHLSMFFGVHVYKVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TGA0</accession>
    <name>A0A162TGA0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CCHC-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_151844</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441026">
        <property type="protein sequence ID" value="OAD66903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284943.1">
        <property type="nucleotide sequence ID" value="XM_018432760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TGA0"/>
    <dbReference type="STRING" id="763407.A0A162TGA0"/>
    <dbReference type="GeneID" id="28993666"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151844"/>
    <dbReference type="InParanoid" id="A0A162TGA0"/>
    <dbReference type="OrthoDB" id="2264205at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD66903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="412" mass="45970" checksum="DC6329E7C20EC054" modified="2016-07-06" version="1">MKEAATQNALPLLKKKLHVIFSSVNNIISRIWRIGFSKFSVFFTIPPKASPKFDPFWRTLLSAYSHEVYMGITLGSRSSSDTCELHLPTIADCKQVCSQPLVVGNLFFLTQAAVPIGTIVCRVFLTKLPRVPYYDLATQLAKCMSLFGKVRKIAIHESYGFFDGSGYVVLANTLTNDVPSDSLTYQIAYDDTQKILGKWPSMGSHCTYCKEMGHDVAKCTKRPAETRTCFGCNKTGHLQANCPYITDPSKTSKTSNKRSRHPNRNSKLDRPIIAPKPLIPTELSLIYGGSEASKHNPRQPALRELSKLSPTKTTFTLPTPTETPTSSGPRPRSRSVDTPTRGWDKEIDDRMITNLMDRDEARALRLQSASRHTHLRFSRPARPTGRNTSLSPPRFTHPQTTKALGAEANINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TIB6</accession>
    <name>A0A162TIB6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_66927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286862.1">
        <property type="nucleotide sequence ID" value="XM_018441709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TIB6"/>
    <dbReference type="GeneID" id="29002615"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_66927"/>
    <dbReference type="InParanoid" id="A0A162TIB6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="187" mass="21120" checksum="AF7259A42AD98D18" modified="2016-07-06" version="1">MLAKIFALMRKKSQGINNSDADLSLKRSCLNTVQASLGDGHTIGKVYKKISEVNTFLRSGKTIITSEDIEAEASKAVEQALSPDSYPVLNQLLQSHIQEEQLYEKYDKTQSAYFEANRCIIKSVVDYLCNQAADKLITPGKIRRKVLHYISSQKLKEKKTDNQTAEMNQVECLSQRHVQIISAYFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TIS5</accession>
    <name>A0A162TIS5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_22165</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286962.1">
        <property type="nucleotide sequence ID" value="XM_018439776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TIS5"/>
    <dbReference type="FunCoup" id="A0A162TIS5">
        <property type="interactions" value="213"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TIS5"/>
    <dbReference type="GeneID" id="29000682"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_22165"/>
    <dbReference type="InParanoid" id="A0A162TIS5"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05574">
        <property type="entry name" value="STKc_phototropin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001236">
        <property type="entry name" value="AGC/RSK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000121">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45637">
        <property type="entry name" value="FLIPPASE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="102"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD68922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="469" mass="53252" checksum="A56CCC4727AE159A" modified="2016-07-06" version="1">MTADKAAIRRVVSVPNGADLLNITSLAQQQKNQENPPLHFLRLHDLHTQQTNHHHDHDHDHDLAPPPTYDSVSALTKHSLCRRTYSTSSIKLRQVEVGPASFQKIRMLGKGDVGKVYMVRQKNTDKLFAMKVLSKREMLKRNKIKRALAEQEILTTSNHPFIVTLYHSFQSQDYLYFVMEYCMGGEFFRALQMRPGKCLTEQAARFYAAEVTAALEYLHLQGHIYRDLKPENILLHQSGHIMLTDFDLSKGSRPPGNPGVIKSSWPYQPLIINTRSCVDGIRTNSFVGTEEYIAPEVVKGCGHTSAVDWWTLGILIYEMLYGTTPFKGDHRNETFSRIVYQDPSFPNQPAPHQTPISSACKNLLRKLLHKDEFKRLGSRAGAADIKQHAFFKTTNFALLRNATPPIQPLIYQSNGIDAVNFRRMPPESFSLDLNTDNVLITEKAGTNPFENFSSVTLHHDGDSDTEDFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TJ23</accession>
    <name>A0A162TJ23_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Serine/threonine-protein phosphatase T</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHYBLDRAFT_127325</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Protein phosphatase that specifically binds to and dephosphorylates the molecular chaperone Hsp90. Dephosphorylation positively regulates the Hsp90 chaperone machinery.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:20630"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287022.1">
        <property type="nucleotide sequence ID" value="XM_018429156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TJ23"/>
    <dbReference type="FunCoup" id="A0A162TJ23">
        <property type="interactions" value="1102"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TJ23"/>
    <dbReference type="GeneID" id="28990062"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_127325"/>
    <dbReference type="InParanoid" id="A0A162TJ23"/>
    <dbReference type="OrthoDB" id="445564at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07417">
        <property type="entry name" value="MPP_PP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000039">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041753">
        <property type="entry name" value="PP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 16" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="17">
        <location>
            <begin position="191"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="15">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAD68982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="488" mass="54436" checksum="D9A9261F9C583AE3" modified="2016-07-06" version="1">MSPVAISDAVKAQAEKIKGEANALFAAKHYKEAIEKYSAAIDLNPNVAAYFSNRAFCHLKLESYGYVISDADAALALDPNFTKANYRRATANMALGKFKEALKDLRVVVKNAPGDKDAKLKLDECAKIVKRIEFEKAIEHDDHAPSAADSLDVDAIVVEASYDGPKIAEDKKITEGFVKDLVARFKDQKKIHRKYAFMIILGVRKMMMESPSLIDIKVPAGGKLTVCGDVHGQFYDFINIFNTNGWPSEKHAYLFNGDFVDRGSFSLEVVLTLFAYKLLFPDRVFLARGNHETDNMNKVYGFEGEVKAKFSDMMMFKIFSETFNSLPLAHVIGNKILVVHGGLFSRDDVTLDDIRKIDRLALRQPGNDGLMCELLWSDPQPQPGREPNKRGVGIQFGPDVTKAFLERNGLDMLIRSHEVKEEGYVIEHDGKCVTVFSAPNYCDSVGNKGAYINITPDMVLDYVTFEAVPHPNVRPMQYASQFSGMLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TLH0</accession>
    <name>A0A162TLH0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_98581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287532.1">
        <property type="nucleotide sequence ID" value="XM_018444056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TLH0"/>
    <dbReference type="STRING" id="763407.A0A162TLH0"/>
    <dbReference type="GeneID" id="29004961"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_98581"/>
    <dbReference type="InParanoid" id="A0A162TLH0"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050659">
        <property type="entry name" value="Peptidase_M24B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46112">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46112:SF2">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="1">
        <location>
            <begin position="163"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="383" mass="42672" checksum="C7F3677E182DF65D" modified="2016-07-06" version="1" fragment="single">PIQPGEYVERQKRLAKVLKDENAGALVVEPGPTMTYYTNIAWSLTERPFLVVLRLDDELPSGINMTIVTPMFEATRALEALKRANLSEEIQPSVIEWVEDGSPYKAVKKALGGANEGTVFVDKDIRMFIFDGIDDVSNEIKVKMAPRSIRTLRMVKSSAEIDILRCANHATLAALQLVRTYVQPGMVESEITKMMTDALETAGLDETWVLALVDENAAFPHGEPGIQRTVTENSTVLIDTGGRLLGYQADVTRTFFLSERGHNQTIEDAWYSVRRAQENVLNRSNSGDSCAEVDLYARRVIEKAGFGQFFTHRLGHGIGEEMHEEPYMNQGNHEQHLSPGMTFSVEPGIYITGEFGIRLEDIVVVNQEGKLEVLTSGLAQNPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TYS5</accession>
    <name>A0A162TYS5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="3">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_113882</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="3"/>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290112.1">
        <property type="nucleotide sequence ID" value="XM_018428360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TYS5"/>
    <dbReference type="FunCoup" id="A0A162TYS5">
        <property type="interactions" value="973"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TYS5"/>
    <dbReference type="GeneID" id="28989266"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_113882"/>
    <dbReference type="InParanoid" id="A0A162TYS5"/>
    <dbReference type="OrthoDB" id="10256524at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048384">
        <property type="entry name" value="TPPII_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048383">
        <property type="entry name" value="TPPII_Ig-like-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022229">
        <property type="entry name" value="TPPII_Ig-like-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046940">
        <property type="entry name" value="TPPII_Ig-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF14">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12580">
        <property type="entry name" value="TPPII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21316">
        <property type="entry name" value="TPPII_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21223">
        <property type="entry name" value="TPPII_Ig-like-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="36"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl-peptidase II first Ig-like" evidence="11">
        <location>
            <begin position="547"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl-peptidase II galactose-binding" evidence="12">
        <location>
            <begin position="687"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl peptidase II second Ig-like" evidence="10">
        <location>
            <begin position="826"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD72072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="951" mass="104919" checksum="EFA8AA9C7AC18FEE" modified="2016-07-06" version="1" fragment="single">MTSISKYIQEYPVNGLMPKQETQAASFIKKYPNYDGRNTVIAILDTGVDPGAAGMQITTDGKPKIIDIVDCTGGGDVNTSAIVKAQTEEDGDKLTYIQALSGRKLIIDPTWKCPSGEYHVGVKPAYELFPTELVNRLKKERSKAFDARHLHLVDEAKARVCSFTKQNSSKLTSDPVVAAELADLETRVEVLKGLKDKYEDPGVILDCVVFNDGQDWRAVIDLQESGDLRGNSSTKKENRQTCLEKERGEPCLTDYRKEFKYHTFGETDLLNFSVNIYEDGNLLSIVTLAGSHGTHVAGITAANFPEEPALNGVAPGAQIVSLRIGDARLGSMETGPGLTRAALHLAINKVDLANMSYGESSASPTDGHFIKLLAEEAIAKSGCIFVTSAGNDGPCYSSIGAPAGMHSSFITVGAYVKHSQMQAEYALLESMTEQPYTWSSRGPCTDGYSGVDIYAPGSAITSVPVYGLHKLDLKNGTSMSSPNACGCVSLLVSGLKAEKRDYSPYRVKAAVVQSAKSVKDPLNVGFLQVEKAWEYLDTYKSRNDQDIAFEITVSKRGPQRGIYLREREETNQVQYLPVTVKPTFMAENNVEDPKYNRAKFNYEARIALVATESWISAPDYLYLHSGGNSFQVKVDPLALKENEFHFGEVLGYDTTAPDRGPVFRVPVYVVKPVLASHGSLEYKKIAFGPGDIVRNFVHVPEGAAYCQLTIRSKSLVNTVPARFMLHLLQLIPKKSQKNKQTYSFVLGSGTYSNSDSEEEVIVKRFAVRGGLNLEVCLAQFWSALGKHTVDLSLEFHGVQLAGNLANGHGVVYFDPQVTRLDVAAPIRKENKVDISVSFNKLRKYIRPYESEIAPLYADRDMLPDKTLLYALVLSYKLKVDASNTMVVRFPTVMNQLYEHYLAGVFGIVYDANCKVIGYLDVFDQTIKLDNKGEYTIRLQLMTEEQDVLEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TZA4</accession>
    <name>A0A162TZA4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_80016</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290252.1">
        <property type="nucleotide sequence ID" value="XM_018443538.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A162TZA4">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TZA4"/>
    <dbReference type="GeneID" id="29004443"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_80016"/>
    <dbReference type="InParanoid" id="A0A162TZA4"/>
    <dbReference type="OrthoDB" id="2503993at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902929">
        <property type="term" value="C:plasma membrane of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024982">
        <property type="entry name" value="Rax2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048266">
        <property type="entry name" value="Rax2-like_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048265">
        <property type="entry name" value="Rax2-like_third"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778:SF2">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12768">
        <property type="entry name" value="Rax2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20842">
        <property type="entry name" value="Rax2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20843">
        <property type="entry name" value="Rax2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1172"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="1296"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1231"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1231"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1244"/>
            <end position="1253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD72212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1362" mass="146086" checksum="D92864DBE6015537" modified="2016-07-06" version="1">MSPMNGLRTLNQPLCFGFFVFIFCFKPFGFDVLSLSFPLLSYFLYFHVMTRTTPGWFILMACLSQVIADPFVMPVINDDSLGFLGLAGDLAGLSVFKDTRQKEYTAPGLHSIISYQNQIYAWLASANGPITATCFLPPNSLYLAGQFTAINNTESRSIVHFDTGLQVLSNLGQGVDGVVHALHCDPAENLVYVGGEFKSPLTSIGATTAGGGANVAIWQTNQQVWMNVPWKGFNGPVYAIEPFVKRNSILFGGRFDATVDGQLYNPQALVYSVYPTAIRGGNSALSENYSDPSSVSCQSKSYGKPWLLQGGVPGYWEADFGHSVSPTVIRISNTHINGRGTRLFSVLALGSNTYFELSTIDPITHTNTTCTTSCILSNDTTIPFQDFTVLTPKVVSAVRINIDGWYGAGGGLSSVEIFQTDIAIYPSLGNTNTSACNSGLASSTLITGVWKEVYVFGYYQNVLTSTFPTSSGTTNVSVTYAPNIPVQGYYVVSMHTPGCIGSSSCGQRTQVDLVLQLTPQNTSTITIDQTNTEDKTTIIYSGQMVASGPSFQPTILLKLSGSATPAKDSTTSIVADSISFIMNATAPNLVSILEYSPGNHTANITAWQPLSQQLTIGSTVRTIDATSEKVWIGGSFLGPNGTQNIAVYDTLFGTMLPLAQNGLNGNVSTVLKVDSELLVGGYFNGTVAGLGLSHLARFDTSHQTWLSFDGGVDGPVEYILVSDNSSVLVSGAFNNLIGVGTNNSSLQRSVGNAMWNTVSHEWMQSTSLVVGQVSAIYNLDKSSLWIGDLRSAQTHRTDSAALGNSLAVYPLVDPHSSYNARAGAVWFTDQNRNQNQNQNQTNLNINLNINSTPFILLAGQSTGPNNSSEIVVYNGTAWTSLFSVSGNIISMVVFKDNLYFGGNFNNENNQTSFSVYDLKNNTFVDVGGIYNADGSPGLVETLYLHPNGESIIVGGDFIKAGSLDCGPVCSFNISNHKWDISGNGLKGHAYQLTSSTEGIVVAGDLTVGNQPTLVAQLPTDTTEWKSDLLASIAPSYIPTTLDWLSNVCTLLYRSDTMSAFIGSWNGHNYTDIGSLLGNLSDIHQLLYVPIASSPHEARYPAGTKNMLMAVGNLVIDPFGNSSAAFYDGVSWYPYILSARLDGRPGTINQLFSNVSCCNITESTQDHYLSTPAVILVSIAASLGLVFLIVAFGLLFLAWKRRRGNRDEPEPMPPWIPSNETTILPVPLSTSATSALPASSTPRTAPIPPVPPMPMSEQTGQAGPSNLSRAGFQNVGFGSLMAAAMATSPEIQAATENTPKLFYARHSFVAKENGELSFSVGDPVVVVDTADNIWWMGYKDDGSNHPIPGIFPSNYVVPSRPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U107</accession>
    <name>A0A162U107_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fork head transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_95545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289493.1">
        <property type="nucleotide sequence ID" value="XM_018443913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U107"/>
    <dbReference type="STRING" id="763407.A0A162U107"/>
    <dbReference type="GeneID" id="29004818"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_95545"/>
    <dbReference type="InParanoid" id="A0A162U107"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20024">
        <property type="entry name" value="FH_FOXJ2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000135">
        <property type="entry name" value="forkhead box protein G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045912">
        <property type="entry name" value="FOXJ2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078:SF2">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078">
        <property type="entry name" value="FORKHEAD BOX PROTEIN J2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="5">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD71453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="77" mass="9057" checksum="8D457D3D767F5D39" modified="2016-07-06" version="1" fragment="single">KPPYSYATLIKYAIENCSERRLTLSQIYQWVIDHYPYYSTAGTGWKNSIRHNLSLNKCFLRVPRPTNEPGKGSYWTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U4D2</accession>
    <name>A0A162U4D2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_65702</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290293.1">
        <property type="nucleotide sequence ID" value="XM_018441512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U4D2"/>
    <dbReference type="STRING" id="763407.A0A162U4D2"/>
    <dbReference type="GeneID" id="29002418"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65702"/>
    <dbReference type="InParanoid" id="A0A162U4D2"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22272">
        <property type="entry name" value="DPBB_EXLX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF21">
        <property type="entry name" value="EXPANSIN-LIKE PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="3">
        <location>
            <begin position="126"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD72253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="212" mass="22556" checksum="6A59ACEBA5273D64" modified="2016-07-06" version="1">MSSTLDIHSEIIDSNSNRQFITNEKKPTGILAGSYSSLPPATLWTRLSNRYRYGRLGLIISGILGVFVVMFIIIGTLGVFKNELYRTRLGLPSVGKTKYKGSSTGTATEGDFNISGEGDDPGVGITACGTQFTAQDYVVALNHVDYGVYANPNESPVCGACIEVTGELGTVKVTIQDMCPGCEQGSLDLSPAAFSKIADISEGRVPVSWTPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U6T6</accession>
    <name>A0A162U6T6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Translocon-associated protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_169083</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Is probably involved in a pathway contributing to genomic integrity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IRC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290863.1">
        <property type="nucleotide sequence ID" value="XM_018436003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U6T6"/>
    <dbReference type="STRING" id="763407.A0A162U6T6"/>
    <dbReference type="GeneID" id="28996909"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169083"/>
    <dbReference type="InParanoid" id="A0A162U6T6"/>
    <dbReference type="OrthoDB" id="1926781at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005595">
        <property type="entry name" value="TRAP_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924:SF0">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03896">
        <property type="entry name" value="TRAP_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007840233" description="Translocon-associated protein subunit alpha" evidence="11">
        <location>
            <begin position="23"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD72823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27627" checksum="D48E7791A88A3C41" modified="2016-07-06" version="1">MAKLTSFWALCLALLATTFVFAQESVPASANLEITAEFPDNPFGLFTQIVSCLIRTLVIVNGQRNKVVLDLNNKENEAYSVVSVSGRITLAEDHTKIIRNLTALRYELTIPAQTRANVPYTFYSEYTPGELGLEVFVDLQAGDKVIRVVGYSGNITVSEPESSWFDPQLLFLYAVLAAGAAGVAYIVREAYFGGKKVKVKKDDVPVERPAHRDDKGQMVLDQSWIPEHHLKNSPRQSPKIKKRPSNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U9K8</accession>
    <name>A0A162U9K8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_103448</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291493.1">
        <property type="nucleotide sequence ID" value="XM_018427766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U9K8"/>
    <dbReference type="STRING" id="763407.A0A162U9K8"/>
    <dbReference type="GeneID" id="28988672"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_103448"/>
    <dbReference type="InParanoid" id="A0A162U9K8"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD73453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="74" mass="8709" checksum="691E488E17702B74" modified="2016-07-06" version="1" fragment="single">EQRKRLWYSVYVTDRWCCAVMGRPLAIADSDCDIDLPRLYGSTDERKNKMDYVLFVNFVKLSGILGEVLRRIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UAZ0</accession>
    <name>A0A162UAZ0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_144247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292932.1">
        <property type="nucleotide sequence ID" value="XM_018431178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UAZ0"/>
    <dbReference type="GeneID" id="28992084"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144247"/>
    <dbReference type="InParanoid" id="A0A162UAZ0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="188" mass="21431" checksum="0DC32B66BB8E8D0E" modified="2016-07-06" version="1">MPPASKKSKLAKSKSQSESGNCFFKNIETSNNDLIDLFEIDIEEDITVDDRELQGIADDVTSAIYSSHFLKWHEEADKSLLESVNEELKPVEATSRKISANTISLLKLAFNNIKEEIASFICISDSSLPVDYYELCKLKSVESYLRYRLSESKTMEASKKAAMELWLLWVTSQERKTHQALVHFTLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UCI5</accession>
    <name>A0A162UCI5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S26 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_110625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S26 family. IMP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293272.1">
        <property type="nucleotide sequence ID" value="XM_018428175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UCI5"/>
    <dbReference type="FunCoup" id="A0A162UCI5">
        <property type="interactions" value="328"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UCI5"/>
    <dbReference type="GeneID" id="28989081"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_110625"/>
    <dbReference type="InParanoid" id="A0A162UCI5"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S26" evidence="8">
        <location>
            <begin position="3"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="8">
        <location>
            <begin position="67"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="4"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD75232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="132" mass="14686" checksum="312F48BA9EA427E7" modified="2016-07-06" version="1">MGPSMLPTFNMTGDIILADHISGYFSEPEIGDVVVCISPHAPGRAVLKRVVGTPRDSVCFDVTEKERKYVNVPDGHLWLSGDNMSNSNDSRTYGPVPMGLLRGRVVARVSKEKKVFFDILVTYFLSCPFSFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UD78</accession>
    <name>A0A162UD78_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MADS-box transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_71488</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292283.1">
        <property type="nucleotide sequence ID" value="XM_018442477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UD78"/>
    <dbReference type="STRING" id="763407.A0A162UD78"/>
    <dbReference type="GeneID" id="29003383"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_71488"/>
    <dbReference type="InParanoid" id="A0A162UD78"/>
    <dbReference type="OrthoDB" id="2284405at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000002">
        <property type="entry name" value="Serum response factor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="SRF-like_MADS-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="35"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD74243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="270" mass="29539" checksum="590F14B5AB93EF28" modified="2016-07-06" version="1">MYNQPADPHHALHNTPATLGDEEDDSDDQKPDKRSGRRKIKIEYIEDKSRRHITFSKRKAGIMKKASSQACLCLCLLSETGLVYTFTTPKLQPIVMKPEGKNLIQSCLNAPEAASDLSMPDIPVNVSAPPTPAPVNSVQVSSSMSLGPSPIEASYGNYPRKTYTEMPGLSVGPSLENEQTSYVDSMSYSLPFGGNAQPHSTVYPYNVPQQSAPVNKDYWRTRSNGSRVTEADGNHQYASISSRLLTSLLLPIVTCLVNIKGLDNHGFVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V8X9</accession>
    <name>A0A162V8X9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_153993</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298993.1">
        <property type="nucleotide sequence ID" value="XM_018433290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V8X9"/>
    <dbReference type="STRING" id="763407.A0A162V8X9"/>
    <dbReference type="GeneID" id="28994196"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153993"/>
    <dbReference type="InParanoid" id="A0A162V8X9"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000026">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF496">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="132"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD80953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="334" mass="38267" checksum="2B3F802D17C0A655" modified="2016-07-06" version="1">MPFFTCNTSSNKVSDAWFDVDIIIEKLLQAHGYQKQKTHCLCEGEIEYLCRTAQTVFLNQPMLLEVASPVKICGDFHGQYPDLIRVFDTCLYPPDSSYLFLGDYVDRGKQSIETICLLLAFKIKYPDTFNLLRGNHETSSISRVYGFYDECKRMFNVKLWKTFVNCFDCMPVAALIDSRILCMHGGISADIINLDQIRAIQRPVDIPDSGILCDLLWADPSNEHTGWQESPRGVSYTFGPDALSKFLERLGLQLVCRAHQVVEDGYEFFDDRRLVTIFSATNYCGEFDNAGCVLKIDRSLTCSFEIFKPTNPKHKHIYCNILNNRSLPLIYIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V9Q3</accession>
    <name>A0A162V9Q3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polyketide synthase-like phosphopantetheine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_62102</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299092.1">
        <property type="nucleotide sequence ID" value="XM_018440902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V9Q3"/>
    <dbReference type="STRING" id="763407.A0A162V9Q3"/>
    <dbReference type="GeneID" id="29001808"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_62102"/>
    <dbReference type="InParanoid" id="A0A162V9Q3"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF6">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide synthase-like phosphopantetheine-binding" evidence="3">
        <location>
            <begin position="564"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD81052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1041" mass="118009" checksum="443BE4A2D6B83B39" modified="2016-07-06" version="1">MKDPINYKESFIDLWNQQSKIHANNVFLRYHTRLNEMEVYKTLSYEQVDNISTSIAWEWSSILYGVKSVGFICDHSAFYLIAQLAIMKLNILFVALSPRNSASANGSLLKATNAEYIIASHKYSRMAYASTAKLDNCKVFIHQPTDLKAVSQKTYNNSKKIPKFFSRVLGREAPVMVLHSSGTTGFPKPITLSNRYILTNIRHIDNCIQDTNPNMIYNSSDVLLPCIPLFHAYGQAMVFSTILHGSSVAFMSQLPPSMKDIKLAIRANKCTFMMAPPLIIEQFSAYLKEKNDFSALQQLKLTLCGGAPIREESGVFWESKNIVIRNHYGSTETGPFMSSSFAPNTIHWNNLRPSRLIIEYCVWEPYFADPELVHLVIKGDCPSMAHGVVNREDGNYGTRDLFKETSPNSGYYSYYGRMDDTLIMKNGEKTNPLPIEATIRQCPIVSQCVIIGESRQCISVLIELSAESPKEYNTEDVIKIVYPYILEANNSAPTHSMLFKQMVYILPPGKTLPVTVKGTVVRKHAYNEYKESIDTLYRDFHSGVSEEPLQNITEYQYIAPEEIKLFLIDAAAKVLNISPNELKDTTKSLFDLGLNSILSIHLCNIISKKLGSVSQNFIFQHPNIDNIQRVLSSRHSPYEVPIEKSLDNTEEILKKYLKQASQDFEITKNSYVKGQDQVVLLTGATGSLGSFMLRDLLKSPQVSKVYCLVRGKEAGALNRIYHAFESRSLDVSLLSSPKLVALPMNLTDEKLGFAHDFYSKLKSEVTIIQHCAWLLDFNHTVEHYDKECIKGLYNLVKFAYRQINPIHLHFISSISASAGWGDTIPESPLPRNTKVAMPMGYAQSKYIVEHLFNYLTKEKNFPCIIERLGQVCGDSINGVWNTSEQYPLMFIGGGNAMKKMPSININVDWIPVDYASACIVNIMLKTAGDISSAEDSVYNIVNPRRVVWRDVLNAMRLCGMEFKTVTLEEWIAQLQQDDKSPASKLLPFYENTLKEFSEAQVWNTNKACYLFPSLEETPTFDARLLNKYIKHWKSIGFYKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162W7A5</accession>
    <name>A0A162W7A5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_153774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441016">
        <property type="protein sequence ID" value="OAD65115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283155.1">
        <property type="nucleotide sequence ID" value="XM_018433251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162W7A5"/>
    <dbReference type="GeneID" id="28994157"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153774"/>
    <dbReference type="InParanoid" id="A0A162W7A5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="323" mass="36693" checksum="0AF239CEA8C770C4" modified="2016-07-06" version="1">MAIQRRQLALRPVEITNEQLMEILSTLKTNMTAMGTNMAADMSIVQEQIGTVEDTLLNMNSRIGVLATSSTETITAIDSLSMAPLVSSTNTMANVSQPAFNAPSEFSKKASNDVYVHIRNLMWDPKLKTRNQVNILANESKPRWNTNVFFYKSPNKELAMRLLENLKRKFTHEGFREADLRARLHKNFTSRVSKARKAEEEIKATNTCLRRAGCARDNHTRHLLAYTDNKEAIDLQMKRDCDFTMQMAAMSDRESADEDFENRTKSIVKIFNTLIKLIDEYVIEAMGSSASQMKERVFTSVSNTAVPDDITSKFPQWALRDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162W7I8</accession>
    <name>A0A162W7I8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_189618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441030">
        <property type="protein sequence ID" value="OAD65175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283215.1">
        <property type="nucleotide sequence ID" value="XM_018439686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162W7I8"/>
    <dbReference type="STRING" id="763407.A0A162W7I8"/>
    <dbReference type="GeneID" id="29000592"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_189618"/>
    <dbReference type="InParanoid" id="A0A162W7I8"/>
    <dbReference type="OrthoDB" id="3044029at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007840559" evidence="2">
        <location>
            <begin position="23"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD65175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="353" mass="38671" checksum="B6F7C4C1895F8DF7" modified="2016-07-06" version="1">MKFIASSALLVLASIVLPSTLAQSSEWLSNDAVSYAAKKTTTPAKNSTSHPLVKLVSETQFCFFLPPGPKLDVATHEDIGVAHCTKSNVIPGVKTFPTGFITVAHFQQTSTYVQVTGYMNSKLFGLIPTDEGGQYDNHGNGKPVGAQCSGYNYFVNVVEPADNRYCIRCCQNKVDCNTGRSAYGCMRVVPGDYSGNTHVNNVLSEINQTPEGSGESTADSSAEEDSEVKEILTETIQYAKDHPDVSEIQAEWDRMTKSLVHSYPDLESQLNDVKSTTDSYTTVEEWNTFFTALESKLSSSTEHNDAVDDTTTTTTTPTAAASAESDYVTNEQLEQEISDIREEFNERIEELQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WVU7</accession>
    <name>A0A162WVU7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_102509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289185.1">
        <property type="nucleotide sequence ID" value="XM_018427728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WVU7"/>
    <dbReference type="STRING" id="763407.A0A162WVU7"/>
    <dbReference type="GeneID" id="28988634"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_102509"/>
    <dbReference type="InParanoid" id="A0A162WVU7"/>
    <dbReference type="OrthoDB" id="3261594at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="164" mass="18130" checksum="FC049ED4C0AA73D3" modified="2016-07-06" version="1" fragment="single">VCPHCNGPRYQRERGTISPVQTYQVVPLSEQLRFKLAHPEERAKIAYGTEVLAGGRSNVRKDILDGDDIYRLLAGGIVGQGDIVVSMFVDQFNPFKDAAMSASIIHVINMNINPAERYKKGNMMQLAIIPGPKHPKNIASFLEPILADLRALQTSGVKCWDGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XHZ8</accession>
    <name>A0A162XHZ8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_67772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293045.1">
        <property type="nucleotide sequence ID" value="XM_018441848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XHZ8"/>
    <dbReference type="GeneID" id="29002754"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_67772"/>
    <dbReference type="InParanoid" id="A0A162XHZ8"/>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD75005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1183" mass="131270" checksum="E1A6A0B5CA39F4DB" modified="2016-07-06" version="1">MAKSPAKPVAAPAKKTPWRGISIKRPAGRPESIASVQSQDSQKSTDSEKQDSSTNLAKVDPSLISVEEELDQSKSCEVSQEPVSPTKTKTKTKENTPKAVTNETQGEENGDVATPRASRSRASSFYGLDSASEVFEDAYDDNDDSLEDEDDYDDDDSPLKSTAAKVYPVTTSGSSTIPHPKEDRKEMFIAKEQLPDFVTEIEGLTIESMSGSVVHPNIKEITADPLETKVAKITNEDDVHTPTNTSAVDPKDVVLKETLFVAEDEITGQEMHAKPKVTDTLLSQPVVGVTPVSKNQSENDPEKVHISSQDLGVAEVANNDILKKSKNFGSETLRTTHDSTASQFPHDKQDTVQKTTALETSAENMATKQDQSTAVAAAVASVLAAAGVVHLPLQSLKQPQNDDSKGVTPLIITDGAEGDNDKLVFHGGDSGIAISQTASDEDSDPEKVSKAPSERTSSDSDDDDRDCLGSILPAISDSLREYNNKEPTRDIKKATDDMENDIEARKERELEFPIEPPVDLDVFKDNTLAIQAIDIKSIPINDFTPRQQEKADEPVQEGINLLFDNQFMRAKGIFQTKANIDPVYALGLGAMAFIKAMMTFDEKDMASAMNALATAYTIGKTQVDNSPYKKPLKDSVFHYFATFGSGSTGLPPSPIPIIPLKDTSNDPPTFIPNGVLRAHVAKAECCLLMGVLQMSQESVIGYLKCGLNLRRGNTDTDTMFKEFFRETMTNKQPLKQIAYNSYSIVWQEYRRMGQEYNNHIDHNTVSGIQFGIGAVHLLMSSMPSKILKIFSTFGWKGDKQLGFALLKLCLEGRGLRSPLASLALLTYYSVLTSFAPQLYAKELMSPAIECLLDAQKNHPNSCFFLFFAAHTSRVARNIPLSTQSFDFAAESSRGEWAEHAMKQLSDYEIGVNLMLQLDWESAAECFENLAQEKYWSPSFAKYVVGACRDMLGERTDGILAFAEVPQLAKEYPTKKTYMDAYVHKKVEFFQRSGYQDMDFSLPGLELILVLNGFEHMDKGCLEKALKRVHETLELIYEREKMEYTIRLRELVPTTTPPNYYDQRAVLLLIKSSILNTLGRYTECISHLNWIIDHKESIKHETWVAPFAYWESGITSWGLGNAQKSRQLWQLALACTKYDFEYRMSVRLTLALNRCDEFGIEAVDTKAKKGPTTNGRKRMPIVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XJ41</accession>
    <name>A0A162XJ41_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Endocytosis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHYBLDRAFT_186332</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the END3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293275.1">
        <property type="nucleotide sequence ID" value="XM_018439224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XJ41"/>
    <dbReference type="FunCoup" id="A0A162XJ41">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162XJ41"/>
    <dbReference type="GeneID" id="29000130"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_186332"/>
    <dbReference type="InParanoid" id="A0A162XJ41"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025604">
        <property type="entry name" value="End3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF174">
        <property type="entry name" value="GH06923P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12761">
        <property type="entry name" value="End3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EH" evidence="17">
        <location>
            <begin position="8"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="18">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="17">
        <location>
            <begin position="154"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="246"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="326"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="246"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAD75235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="383" mass="44223" checksum="E488DAF9C910774D" modified="2016-07-06" version="1">MNPITPAERAKYAEIFQARGQMNGYMPGATARDVLLNSNLPPHRLERIWDLADIDKDGNLDFEEFCVAMHLTFSCINGIEPPMSLPPHLVPPNKSHFFAIQPQQTAVYAQPTGYAYQSPNTYAPYNSYSPQHNIPQPPLPQSAPEFSWDMTSQELESYQRTYSKYAHNSEKAKFVQFEDFYSSLGLSRTDLTNAWALVNVNRTTAITKDQCLTFFHILSQRQQGTIIPKTLPPDLQEAFGSEYEGSLRDRVSTGKYRDDRGPKSANKREEEDRLKRELEDLKRRVRDAEERASEPSKEDTSAFGSRPLKDQFEALYEYKLRQLTDQNDVEAKVRQQERDIEAARDAVRRLTRVVDDVRSQKREMETLLEDTRAQVQNTYKQMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XLY4</accession>
    <name>A0A162XLY4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ketol-acid reductoisomerase (NADP(+))</fullName>
            <ecNumber evidence="6">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Acetohydroxy-acid reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PHYBLDRAFT_186453</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="6"/>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293665.1">
        <property type="nucleotide sequence ID" value="XM_018439248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XLY4"/>
    <dbReference type="FunCoup" id="A0A162XLY4">
        <property type="interactions" value="442"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162XLY4"/>
    <dbReference type="GeneID" id="29000154"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_186453"/>
    <dbReference type="InParanoid" id="A0A162XLY4"/>
    <dbReference type="OrthoDB" id="10255643at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000003">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000005">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
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        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371:SF1">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14 17" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="12 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="18">
        <location>
            <begin position="51"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="19">
        <location>
            <begin position="246"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OAD75625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="397" mass="44023" checksum="FC1A8F42719DF93E" modified="2016-07-06" version="1">MASRVFSTAIRTAARAIARPAIRPASILAANVKTTAFKSVVASQARGFKTLNFGGSEETVYERSDVPKEKLLDTFKNDTIAVLGYGPQGRGQALNLRDNGVNVIIGQREGKTYDQAIEEGWVPGKNLFPVLDAVEKGTVVMNLLSDAFQKEFWPKMLPLLTPGKTLYFSHGFSVVYKDQTEIVPPKDIDVILVAPKGSGFTVRRLFQEGRGINSSFAVHQDASGHAKERTIALGIGIGSGYMYETTFEKEVYSDLFGERGVLMGAIQGLFQAQYEVLRANGHSPSEAFNETVEEATQSLYPLIGERGMDWMYSNCSTTAQRGALDWWKPFHDASKPVFEQLYESVKNGSETARSLDRNSQPDYREKLEEELKEIADSEIWVTGKTVRQLRPENVGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XR12</accession>
    <name>A0A162XR12_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_76042</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PRA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294295.1">
        <property type="nucleotide sequence ID" value="XM_018443116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XR12"/>
    <dbReference type="FunCoup" id="A0A162XR12">
        <property type="interactions" value="383"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162XR12"/>
    <dbReference type="GeneID" id="29004022"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_76042"/>
    <dbReference type="InParanoid" id="A0A162XR12"/>
    <dbReference type="OrthoDB" id="63113at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317:SF0">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD76255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="181" mass="19641" checksum="EDB2E49F979EDB5F" modified="2016-07-06" version="1">MSSQPFLSETAQSQLGAAATAIGSDPRFSFLTKLREGRLANLRPLGDFFDKNRISFTSSFQTISQRWNYNLQYFSANYFVIILGLAIYAIITNWLLLFTIGFIFGGFYLISRMNGPVTIAGNTISASSLYAFYAGASFLLLLFSGATGAIFWIIGAAAMIVLGHAAILEPGIEGDFADGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XY41</accession>
    <name>A0A162XY41_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcriptional repressor Tup1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_78991</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295245.1">
        <property type="nucleotide sequence ID" value="XM_018443408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XY41"/>
    <dbReference type="STRING" id="763407.A0A162XY41"/>
    <dbReference type="GeneID" id="29004313"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_78991"/>
    <dbReference type="InParanoid" id="A0A162XY41"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="144"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="183"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="267"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="461"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD77205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="55328" checksum="186A837E79CF69FF" modified="2016-07-06" version="1">MDSLPTARKPSPSSAGGLTTLKPSPSSLGAGVNRDQQVEKLLKEVKQLKQKVDILDKENIALKKSIYDLSTRYAASISQGGLPYRPGPFVIADTSPGSKGMITKAQEMITKAVQEAGGHDTFQSAGKYPHDSRDGKAFQMRYELKGHTGAVYTVEFSPNGALLASGSFDKTVRIWDTASAQKEARHALNVSDLSWTSDSSMLLSGAYDETCKTWDVDSGKLVGSYDTEGFVQCVGWDFVDSNIFYYGTSRKVLAVIDVRTDGPAAAIIRNDAMVNTLYPSRDGVHVITGDAQGMLKVWDIRSKQCISAVANDSGKMPITHISIGRRRTDASRRAVDDYDEPRYMAVNSYDNLMRVYDRGMDPPKSELRIVHALKGFKNKNWPIKGSFYCGSGYNSSIISRPTVPFINDLYSDPDLVSNPGEYFDVAEPKEEKSVLLATGSADPYAYLYNVGEDSAELMQRLEGHTDRVYAVNFHPTEPILASCSADCTVKVWGPSPSRGKKKAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YC80</accession>
    <name>A0A162YC80_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_27479</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297705.1">
        <property type="nucleotide sequence ID" value="XM_018439912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YC80"/>
    <dbReference type="FunCoup" id="A0A162YC80">
        <property type="interactions" value="695"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162YC80"/>
    <dbReference type="GeneID" id="29000818"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_27479"/>
    <dbReference type="InParanoid" id="A0A162YC80"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.990:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006746">
        <property type="entry name" value="26S_Psome_Rpn12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="79"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD79665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="266" mass="30069" checksum="A1292AA4D42EBF53" modified="2016-07-06" version="1">MSASPKQLATLRDQLKAEIGSPSTNLQKCNQLLAQSKIVMAELGAFTPTPGKPDASVLLVARDILETGVYYSVRVKDIASFERYIAQLNTYYHDLASVLPPSPQMYPLIGLNLLRLLSQNRLSEFHTSLEAIDPEQLQSSTFIKQAVDLEQFLMEGSYNKVWSTRSTVKGDEFMFFYDILINTIRNEIAGCSEKAYEFLPLQDAGTLLFLKNTEEILNFANQRGWKVNPVEQKIYFGTEDSNAVEIPQEQIITQTLAYARELERIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YHF7</accession>
    <name>A0A162YHF7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_138260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298755.1">
        <property type="nucleotide sequence ID" value="XM_018429963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YHF7"/>
    <dbReference type="GeneID" id="28990869"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138260"/>
    <dbReference type="InParanoid" id="A0A162YHF7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="73" mass="8657" checksum="E44306D13A050F96" modified="2016-07-06" version="1">MVMIKELELLEELTKGTFGFPIWQRKARPIGEKFSLELPLLIPKSFMETEQTLCVPRRQRSLSYWLLFEVVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YHZ5</accession>
    <name>A0A162YHZ5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_138365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298855.1">
        <property type="nucleotide sequence ID" value="XM_018429981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YHZ5"/>
    <dbReference type="GeneID" id="28990887"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138365"/>
    <dbReference type="InParanoid" id="A0A162YHZ5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="60" mass="7314" checksum="FEDEB2DD0B964053" modified="2016-07-06" version="1">MSTLKQRHSEILQETLRYRERGNVPIKTISRLVTKYETPEYAAYKNVFDRSKWIPTREER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZAF8</accession>
    <name>A0A162ZAF8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_90195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441028">
        <property type="protein sequence ID" value="OAD65431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283471.1">
        <property type="nucleotide sequence ID" value="XM_018443746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZAF8"/>
    <dbReference type="STRING" id="763407.A0A162ZAF8"/>
    <dbReference type="GeneID" id="29004651"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_90195"/>
    <dbReference type="InParanoid" id="A0A162ZAF8"/>
    <dbReference type="OrthoDB" id="784962at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="3">
        <location>
            <begin position="17"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="3">
        <location>
            <begin position="154"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD65431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="234" mass="27156" checksum="B7EC29E57F6A2343" modified="2016-07-06" version="1" fragment="single">MTKDQIKYCGAIIRHLKKHRDAAPFLHPVDYISLNVPDYPKIVKHPMDLNTVDRKLSGQEYTDVEDMIADIRLVFSNCYKFNGPEAMISMLCQNVESAFEKSLHGRPKREIHPPPSKDYPETITKRRTMMMNPRKNDVETKFCSQTLRELKKSKYRDINFPFLAPVDIVALNIPDYPSIVKNPMDLSTIESKLAEGFYDSPEAFEADIRLMFKNCYLYNPPAVPVHRMGRELEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZCU1</accession>
    <name>A0A162ZCU1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_152915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="KV441007">
        <property type="protein sequence ID" value="OAD65891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283931.1">
        <property type="nucleotide sequence ID" value="XM_018433027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZCU1"/>
    <dbReference type="GeneID" id="28993933"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152915"/>
    <dbReference type="InParanoid" id="A0A162ZCU1"/>
    <dbReference type="OrthoDB" id="2286272at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD65891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="120" mass="13620" checksum="1D86AF4053D36A1D" modified="2016-07-06" version="1">MSHLPGVLFFWKDPERPIDMILLQSDQSESFVETSGIAALLLDGGHTEHSLFKIPLKLDVNSMSSMISKDMFHDVSQTMQDIMKSMNPLLEHVPFGEISLSLEEISVRFYLLSLKPLELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZE40</accession>
    <name>A0A162ZE40_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_152738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441005">
        <property type="protein sequence ID" value="OAD66171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284211.1">
        <property type="nucleotide sequence ID" value="XM_018432983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZE40"/>
    <dbReference type="GeneID" id="28993889"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152738"/>
    <dbReference type="InParanoid" id="A0A162ZE40"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="208" mass="23351" checksum="892F6C40D1F604B1" modified="2016-07-06" version="1">MENILFCKAGIHHCLGGEVVTRGPRDRRASNFEAASNDVAGSQLWSNPTRKTLVAVASKTGMNYHTLVCFLADLWGQNVVSMVEETNWVVCTSKMWKDQVVYRVQSSFNSTHVLANDLVVLKHLWGYGFVCKFFSYSVLGETRLFAIVDHLCGIQHNNEGMFLVWESTTIGDKKVVDVKSIKGMAGLIHDVNDETIRHVVEVSQSHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZHU5</accession>
    <name>A0A162ZHU5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Gamma-secretase subunit PEN-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_152135</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PEN-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441000">
        <property type="protein sequence ID" value="OAD66871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284911.1">
        <property type="nucleotide sequence ID" value="XM_018432845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZHU5"/>
    <dbReference type="STRING" id="763407.A0A162ZHU5"/>
    <dbReference type="GeneID" id="28993751"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152135"/>
    <dbReference type="InParanoid" id="A0A162ZHU5"/>
    <dbReference type="OrthoDB" id="524898at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070765">
        <property type="term" value="C:gamma-secretase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019379">
        <property type="entry name" value="Gamma_Secretase_Asp_P_PEN2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16318">
        <property type="entry name" value="GAMMA-SECRETASE SUBUNIT PEN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16318:SF0">
        <property type="entry name" value="GAMMA-SECRETASE SUBUNIT PEN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10251">
        <property type="entry name" value="PEN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD66871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="11168" checksum="8E387EDFB4020CC0" modified="2016-07-06" version="1">MPKLDKMSNDELITISKKMFYGGFAFLPFLWLVNVMYFFTMCRKSTAPPALRKYVLMSLAGCILSFIALTTWYAVFVNKRVQWGQSADTITVVIPKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZMY5</accession>
    <name>A0A162ZMY5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_173853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285981.1">
        <property type="nucleotide sequence ID" value="XM_018437119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZMY5"/>
    <dbReference type="GeneID" id="28998025"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_173853"/>
    <dbReference type="InParanoid" id="A0A162ZMY5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="150" mass="17557" checksum="E63F62043E65A81D" modified="2016-07-06" version="1">MIETQLFFVSANCNVSDLQENQYKNLLKLVELYFVIARFLFLNTVQGPSLGGCACSIAICLLPKFRQFKEKRFIFLISSHFVKRIIKHAILYNSIEAFCIKFIFAKVDTLQSLGVLINSFAEFNFFQKLKHLDGSHRRYMKIFILKRKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZPJ7</accession>
    <name>A0A162ZPJ7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_173259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286291.1">
        <property type="nucleotide sequence ID" value="XM_018436979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZPJ7"/>
    <dbReference type="GeneID" id="28997885"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_173259"/>
    <dbReference type="InParanoid" id="A0A162ZPJ7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="162" mass="18857" checksum="521137B934411896" modified="2016-07-06" version="1">MFSIPLQTFTYGESYVYVFLSALLKCTKINSELDIVILVDSNFITITTSKNSDNKQARAQIFQKIITISRLSLYRISLYRDLTILYWPIIRKNYLNPDRKLSICTPLFASSVCFLLKWCKFPEFQGSMLFESEKIGYFDQHSSNCNIINLEEVDHNVSHQVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163A4F7</accession>
    <name>A0A163A4F7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_74031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD71011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289051.1">
        <property type="nucleotide sequence ID" value="XM_018442967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163A4F7"/>
    <dbReference type="GeneID" id="29003873"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_74031"/>
    <dbReference type="InParanoid" id="A0A163A4F7"/>
    <dbReference type="OrthoDB" id="2442555at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="167" mass="18671" checksum="76C6A9E79A118E91" modified="2016-07-06" version="1">MPISNNSLKFVMDKYCEMVSHNGSADQTQFSGVAFNPLCNFNQEIVDKMHGEVLLRSVTDVFVNHANMEWTRALAGNPAVTNLLSLKSFLPTKVNEATTKTIVAQKPKTNLLEKVDSDSVPTAESIGQGSYRKLLREKIQTDFDAATVETDEFTLQKQINFAYVKYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ADI0</accession>
    <name>A0A163ADI0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL45</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L45, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_187153</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL45 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290771.1">
        <property type="nucleotide sequence ID" value="XM_018439338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ADI0"/>
    <dbReference type="STRING" id="763407.A0A163ADI0"/>
    <dbReference type="GeneID" id="29000244"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_187153"/>
    <dbReference type="InParanoid" id="A0A163ADI0"/>
    <dbReference type="OrthoDB" id="19619at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051975">
        <property type="entry name" value="mtLSU_mL45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L45, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tim44-like" evidence="9">
        <location>
            <begin position="96"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD72731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="258" mass="29188" checksum="464E6B4FC7F9ACFA" modified="2016-07-06" version="1">MASNLRSLRFATLARQSTGFWASQTQQPIGSVVAKSALLSIRTYATRDAPGKLVLMRDHGVFANYIPSDTAPPITDFKNWRLTKWRNLMNNAQNLLSVGLIKYKSQFDKWNSAQFLAVAEETYKDMNDAFARGDRTVLEEVCLDSMYSNLKNQLKQRGNARWEWKYHGDAEAPKIVCVRCVGTTGMSKHGFAVGQVTVKMVTKQSMAVFDKKNRLIGGDPEKIHTVQEYIVFQKTISDPEDIWRIYGKIAPPSKTLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AFX3</accession>
    <name>A0A163AFX3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_145624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291261.1">
        <property type="nucleotide sequence ID" value="XM_018431495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AFX3"/>
    <dbReference type="GeneID" id="28992401"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145624"/>
    <dbReference type="InParanoid" id="A0A163AFX3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="867" mass="95710" checksum="1EBAC7B1B1D67C04" modified="2016-07-06" version="1">MPGTMASGILNIKSSHSISLDSITIGFQECFYYKTGVFDWDEDKIMLLQQPILRGGSESIKCLSGDNLFPFSLHIPAYSSSSSSVRGRDFKFSFEIVVSCRVSLCKFPFKTTIEVDYDPAVATHPSFYPEVANSEPWVPIKSDEERYGRDPQGTRDSPGVASNGGNNENSGSSSNTSRNEYPSSNVNMNAPIGNTSEHSPLRNLDTISPEDPSNIQAGEVEMQIINAPTGNTTEPSPLPNVSTISPEDPLTSSAEDVEIQNINAPIENTREPSPLRNFSSVSPEGLLASLAEYTEIQSINEPIENTREHSPLRNVDTISPEDPLISPAEDSEMQSINAPIGNAREHSLLRNFSSVSPEDLLASIAENSEMQIINTFIENIGEHSPPRNVSTISPEDPLTSSAEDVEVQIISTFIENIGEHSPPRNVSTISPEDPLTSSAEDVEVQIISTFIENIGEHSPPRNVSTISPEDPLTSSAEDVEVQIINAPIENTREPSPLLNVSAISPEGILVSLAEYTDTNTPIRNSGESSPLHNSSPHLSDIPLTSQAEGIEFKNKSRVSLGNTFLRVISLLRNILPVYPRPSRNNQASERNHSYEPQIPSSSSPQPPPPPPPHPSDTDRANENSGRFPRTYPMVQMARYFGSDMPPSFEESRQIATYEKIVDRGTAVVSLKRTYYNIYDPRRILVTVTFHSAFYENVWLNGPPKVHAVLRRLVKVTHHVHNRTTCKKVSENSDYMSPTQVFKIVGEEAYTLEAEDPALYARLCLSVPVKERFVIGIESPLCKVEYTLTVYMKEFLWDIRSSNWGFHKSKLVEVPIFFSTLKDGEICHPSSLLSHSPPLVPGVRVLNIRDQGAELISDTETVPSYASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AGL3</accession>
    <name>A0A163AGL3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Very long-chain fatty acid transport protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Very-long-chain acyl-CoA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PHYBLDRAFT_65949</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities. Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291381.1">
        <property type="nucleotide sequence ID" value="XM_018441565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AGL3"/>
    <dbReference type="STRING" id="763407.A0A163AGL3"/>
    <dbReference type="GeneID" id="29002471"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65949"/>
    <dbReference type="InParanoid" id="A0A163AGL3"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000019">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="FATTY ACID TRANSPORT PROTEIN 3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="19">
        <location>
            <begin position="58"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="20">
        <location>
            <begin position="511"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00078285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OAD73341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="632" mass="71788" checksum="527E80677A04D2F5" modified="2016-07-06" version="1">MFPEYISAATAGVVFGGMYLDSITSFTRDWHQIKIILTSLIKHHIWASQDKINIYNRFRDIAKDYPERYFVIFEGKPYTFRDIERGSNQLARWLLTQDVKIKDTVCMMHQNHPTFYIILFAILKIGAIPAMINTSLTNTSLTHVIKIAQTKVFVFDPCYIESVNAVEGELRNLGISLFAYGEATENSNIDPLPFAPAVTPQFLTEFTDRNLSDHFTKGIISSDPALLVYTSGTTGLPKAAIMEHARMNFAMDFYGTVAEITIGSRLYCVLPLYHGSGILFSTFATMVRGGTVVLGRKFSAKRFWDDCVENEVTAFSYIGEFCRYLLSQPVHPMENKHKIKAIVGNGMRPEIWDRFRERFGITTILELYSASEAPTSLMNVNKNDFGAGAVGHRGSLFRTLRGDIKIIEVDPSTEEPVRTKDGLCKICKPGQYGELVVFVNKNAIMQFRGYYKNEEATTKKVMHDVLKKGDSYFRSGDLLKMDRYGFFYFADRLGDTFRWKGENVATTEVTHVISQFADIEESNVYGVEVPSHDGRAGMVAIVTKEGHSIDFTQLHNYLTKNLPKYAIPIFIRILPTMQMTETFKQLKTVYRSQGIDPSLIPKNEPVYWLKNGTYVPFTDKDWHILNNGNAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B1J5</accession>
    <name>A0A163B1J5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_179983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295811.1">
        <property type="nucleotide sequence ID" value="XM_018438244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B1J5"/>
    <dbReference type="GeneID" id="28999150"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179983"/>
    <dbReference type="InParanoid" id="A0A163B1J5"/>
    <dbReference type="OrthoDB" id="2220024at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14177" checksum="2A1EB29D318DFCDA" modified="2016-07-06" version="1">MTSKATQEYRASFITLISQLTVIEKKGQEFFDRIENSVWTPYVPTSAQTDFEQLMISLQNLETHARTSGLLSIAGSSTDAADGQSSPQPKNLAVRDADTLQAVDTFFQEKNRLLMNIRAAVNAAHRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B3Q7</accession>
    <name>A0A163B3Q7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_76316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD78151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296191.1">
        <property type="nucleotide sequence ID" value="XM_018443140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B3Q7"/>
    <dbReference type="STRING" id="763407.A0A163B3Q7"/>
    <dbReference type="GeneID" id="29004046"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_76316"/>
    <dbReference type="InParanoid" id="A0A163B3Q7"/>
    <dbReference type="OrthoDB" id="26838at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="2">
        <location>
            <begin position="119"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="784"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="841"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="486"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="554"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="801"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="844"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD78151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1150" mass="126411" checksum="D3534E18ADC61BFF" modified="2016-07-06" version="1">MDSEASPTNTEETVLSVHTYWKNTINVCEAALSMLSVYENKDHALVDATTEPLRQLIRHGRDIKAMMEYKPTPRDVNTSPKKQRKPVQINSDYDSNWEIVDSSTVNVTLSDNSVVVCKAISTRKELEEIIPEIRQSRCVALDCEFLGIKNSSPELKLLQIAVSRTRGYAVMINTIGNRVAMELLGPILTDNSINLVGWAFNADGRAIENAFKGLLVTSVLDLQAKLRSIVVENLSLANGVTRFAKDWEGYEEFQKAKQLGEMFHFTGENCVWMQDPLPPSALVYAVFDVVSLVALFEITEHEETNEKHFWPFSITLEYNRKALDKWHRERASNFAEGNNNVYIRNTPKPSLPQPAQRTSENSTSVVPSNGETQSNENAQNKSEKTVEQPTKKSFETDHVAPAEISPQQPTSNGSDNILSHTKSDRRIVSDEQTNYHELEASHSEDSYEYQFAPDVYEESRKNTKAPVIKPGGWSDFTRNLPANKQNTNSNGNVSGSISGSVSGNVGGNTGGWGPLTNNSAVSNPSGWAALANNSSNRRSENSGLGLSSLPTTNQSYPSRQPQSPQLRQPQSPQSAQSPQQRPIQAQKGPASLQLQTNPLPVKQRVPLAEHYSEKPDPQRPPQSINKPAALLVSSTPSVSDSMFAPVSPSTSASLTATNPTQSNLRPYSAPPQTIQPSNFSQNNIKSNSSNDSGVGKASSQDAEPAWVKVKRGLDNSAVNAQSAAFQYGGQGSFEWQEPVEGEIDDEKWKELMDNSITHWRQGKDMGLDMSNYERKKAEAAKNINRPTGSTKFNTVIGTSGDQRRGEKDSWDDVTVRPNTMQMALKGGPKIKYKPKGPRFYNAFDDADSDSDTDNDGLSSDSDGGGLDRNMAVGAKANRMGTTATSSSSAKAGTTEITGAAGSIGASGASGAGANAGASDDEIFVEDFYLVDGTYLHLYKINEVKHLAHIPKSLPDPSSPLTIAFTYYAYVPRNRRMDAGMILKALQIHFPTGNTYTILVEHIYNALHTKKNNELAYLLTHPRVNRVTWAIGFMAKTIEETLGIKLGSALDMSLKLGGTDGHQPNFLQCAEKYIKDWPNLGILKAAKDDFESASNRNFSNSIWDRENVPIMALQYSSLQCAALYTLYTSTEKTIPDTRAFMYPDYQVAQNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B3Y6</accession>
    <name>A0A163B3Y6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxisomal-coenzyme A synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_34261</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296211.1">
        <property type="nucleotide sequence ID" value="XM_018440027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B3Y6"/>
    <dbReference type="FunCoup" id="A0A163B3Y6">
        <property type="interactions" value="364"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163B3Y6"/>
    <dbReference type="GeneID" id="29000933"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_34261"/>
    <dbReference type="InParanoid" id="A0A163B3Y6"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05926">
        <property type="entry name" value="FACL_fum10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045310">
        <property type="entry name" value="Pcs60-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="12"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="426"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD78171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="57431" checksum="7662B786B62BFA71" modified="2016-07-06" version="1">MATTIFSVFENKQNLDKTAVIIPSSAPIPASLTYKQLLDVIYDFANKLSQAVPAEALKPGSSISISYINSLEFVVAFLGVGFMRLIASPLNPAYKKDEFNFYLEDAQSTIMIVPAGASKDPKNAAVSAARDRGALVVEIHWNGKSLDVELVGGSKGSGSHRKIESFKPQTEDIALLLHTSGTTGRPKGVPLTQLNLATSMNNIVHTYELNPKDRTMLVMPLFHVHGLVCGLLATLLAGGSAVIPQKFSASHFWKDFTDTGCNWYTAVPTIHQILLRNPPASVPNIRFIRSCSSSLAPATFHAIEKHFKAPVLEAYAMTEASHQMTSNPLPKFGPHKPGSVGLGQGVEVVILDDEGNPTIEGEVCIRGANVTHGYLNNVEATQKSFTKDGYFRTGDQGKKDKDGYLVLTGRIKELINRGGEKISPLELDAVLLSHPKVAEAVSFAVPDDMYGQEVHAAVVLRPEASKETHRAIERELTSYMVTKVAKFKVPKRIYVTEHMPKTATGKIQRRVVSETFFKPQQQQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BFK3</accession>
    <name>A0A163BFK3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_161895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299321.1">
        <property type="nucleotide sequence ID" value="XM_018434520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BFK3"/>
    <dbReference type="GeneID" id="28995426"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161895"/>
    <dbReference type="InParanoid" id="A0A163BFK3"/>
    <dbReference type="OrthoDB" id="2404451at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="504" mass="58171" checksum="69A8182FADF8287C" modified="2016-07-06" version="1">MLADPATRELLCYRANWESVAGQLTDIFDSDNYKQLVQQGLFSNPDDIVIGLYTNRFVNQKKGKNSYTIIHCIIFNLDPSIRRHGMYFDDISARLRPMEDFKVGNPSKNIYQLRIYTQLSTFSGSSFFALDELHLIARGIGKLVYDLITVTLTKETKFYYTHPDNTLNTTKYAFHIPRADLVARLPCNGRRHQNCLMRWSHTSSTGTRFYTNKSRIIPCLVVFSDQCNITWSIYPISSSSKTPCDATPLAQWRDFLIERFAIHNYTSMAISICDEINLIRPKPYGRESYVDLPNDPSGAQLWEPFHQFVNLNDDLVEGVGGPSVKEALLKYYQRTTGLTGHEFGDSVVVVAARLWMDLTVYSSCMYQRKKNETSRGNHYVMFTCPYRNNRNVIVHSWLVGTVQFYFQHVDFYDFSHFLAFVEVMKEHDVTGYDSSVPIDKQWSQSTHTLGHQTQPTYAVISVNDICHQVGLIQYPPNRNQFYVIAPYYIFNNNMRITKGNLSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163D4F6</accession>
    <name>A0A163D4F6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_173068</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286690.1">
        <property type="nucleotide sequence ID" value="XM_018436934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163D4F6"/>
    <dbReference type="GeneID" id="28997840"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_173068"/>
    <dbReference type="InParanoid" id="A0A163D4F6"/>
    <dbReference type="OrthoDB" id="415315at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="12"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="107"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD68650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="37174" checksum="1C00BF12505D9C32" modified="2016-07-06" version="1">MSSQKQSLSQAQVFKYHFIAGAVGLSLSYSCMHPLDTIKTRIQADPLNGWKSIFTRQTAQSLGKGFFVSALGAAGQGGARFSTYEFCKSYLLPTKDNGNTKLIPWLGNTPATALSAVIGDLASSVIKVPREVITAKLQTDHYNNILKGERATAGFVVRQTLLEEGPRGLFKGFWAIAARDSPFMIILLVSYENFKAFHHRSVRDNWLSAPRKAYDPVVANAPFEELEADIPTFRSIMYGGISGFLAGYFTTPMDVLRTRMITQRATPNRQSATVTDVAKSMINRVMTQYKTPGQRAVQMSQAFFVGAIPRSFWWFGICGIFFPTYETLKSVMVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DFJ6</accession>
    <name>A0A163DFJ6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_170983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288940.1">
        <property type="nucleotide sequence ID" value="XM_018436460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DFJ6"/>
    <dbReference type="GeneID" id="28997366"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170983"/>
    <dbReference type="InParanoid" id="A0A163DFJ6"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="119" mass="13850" checksum="3B7CA95870296D0B" modified="2016-07-06" version="1">MPNMARVELSFHELGSQLSRGNQFDLWFDSGGATRSAKMRPTVRLQRLQMESRIFRDSTKRPKIRYVKRNKFPFDYVGLTGYTNCTTTTAQLQLQLQLAIETVTKENQTKMKSKIELPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DIM1</accession>
    <name>A0A163DIM1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHYBLDRAFT_155738</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Cytoplasmic vesicle</location>
            <location evidence="10 11">COPI-coated vesicle membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Golgi apparatus membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289530.1">
        <property type="nucleotide sequence ID" value="XM_018433432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DIM1"/>
    <dbReference type="STRING" id="763407.A0A163DIM1"/>
    <dbReference type="GeneID" id="28994338"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_155738"/>
    <dbReference type="InParanoid" id="A0A163DIM1"/>
    <dbReference type="OrthoDB" id="10266042at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000003">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="14">
        <location>
            <begin position="271"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="136"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAD71490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="519" mass="57885" checksum="5BBC73F43B735148" modified="2016-07-06" version="1">MVVLAASIVTKSGKAVISRQFREMQRSRIEGLLASFPKLTSTGHQHTTVETEHVRYVYQPLDDLFIVLITNRQSNILQDIESLHLFARVVTDICRSTDERDILSKSFELLCAFDEIISEGYQENVNLAQVKSIIEMESHEERIQEIIARNKEQEAKEELKRRAKQFEMQKKEAAKRGQGFMQGNFSANNYMGGQHSPSIDPTIQTSVESSTMSFGRSSTPPVTSKAKGMQLSRKPKTADLFEAIKTEVEPVRAVPSASSAPTNSTGFAKHQESVHIDIEERVSLAANKDGGLEQMDIKGVLTLRVVDNASARVRISIRATEDSAIQFKVSHIYIDTHPNVDKVAFKNENVVQMRDLARPFPTNQNLGVVKWKYTTRDETAVPLSVTCWPSPAGDGTCDVNVEYELEADHLELRDVVISVPLPAQPIANVNHVDGSYYVDHERHVLEWRLPVVSSANKSGLLECNIPGDNADSFFPVMVSFVSDKLICDVDVLQVQNLDTNTPALFSKEVLLVADDYIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DIX1</accession>
    <name>A0A163DIX1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_70115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289590.1">
        <property type="nucleotide sequence ID" value="XM_018442217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DIX1"/>
    <dbReference type="GeneID" id="29003123"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70115"/>
    <dbReference type="InParanoid" id="A0A163DIX1"/>
    <dbReference type="OrthoDB" id="10559764at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="100" mass="11354" checksum="AF8EB09E3C2ED2A9" modified="2016-07-06" version="1">MELDAVGNATAADHFFGKHFQKAFKSGKTEFKCYCYGCSKEHPLLQIPDQILPENTTIILPRLSTFLNERITPIRNRLPTIPVNKATLSRNSQEIIPVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DT26</accession>
    <name>A0A163DT26_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_65842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291280.1">
        <property type="nucleotide sequence ID" value="XM_018441542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DT26"/>
    <dbReference type="GeneID" id="29002448"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65842"/>
    <dbReference type="InParanoid" id="A0A163DT26"/>
    <dbReference type="OrthoDB" id="2421456at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="210" mass="23795" checksum="8160BE4E57D74D5B" modified="2016-07-06" version="1">MTIKKVIKGDLALNFYFILLACPASLSVRFPARNIIADDTLKSNENDSELTCYRKVAPLLDILLKDLNLNLLNGETTSKASKSIAKDHENIYGNNIPLNRGFGRRIDLLLMNKAILSRLLELPLSENDSKNVYTLGMDWVGPRGYMFAVKKINDIYIAKHTNNLSIPEYLHQLPSFIATLKSLYIWKNHHTKLQDTILKGVIAKGDDDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163E9G2</accession>
    <name>A0A163E9G2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_157772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295530.1">
        <property type="nucleotide sequence ID" value="XM_018433674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163E9G2"/>
    <dbReference type="GeneID" id="28994580"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_157772"/>
    <dbReference type="InParanoid" id="A0A163E9G2"/>
    <dbReference type="OrthoDB" id="2289384at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD77490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="59" mass="6654" checksum="1B61426CDB771D94" modified="2016-07-06" version="1" fragment="single">MDSSSFERFHPTGIDTGQSLLLTKKFVYKPKSTNPFDNEYDEPNAKTTPRSPFDDNGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167J6H7</accession>
    <name>A0A167J6H7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_153670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441011">
        <property type="protein sequence ID" value="OAD65278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283318.1">
        <property type="nucleotide sequence ID" value="XM_018433221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167J6H7"/>
    <dbReference type="GeneID" id="28994127"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153670"/>
    <dbReference type="InParanoid" id="A0A167J6H7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="89" mass="9680" checksum="40BA72FF5B7315DB" modified="2016-07-06" version="1">MGSHIRAHNQQTIRAVDMPLCPIIISDTIYLASALKNQEESSDFTIGSPLENCHVIAGDCTKGSPSTSVPLVYLRHAMGCFPRLKVVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JH61</accession>
    <name>A0A167JH61_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal ATPase PEX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxin-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_86149</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441007">
        <property type="protein sequence ID" value="OAD65977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284017.1">
        <property type="nucleotide sequence ID" value="XM_018443635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JH61"/>
    <dbReference type="FunCoup" id="A0A167JH61">
        <property type="interactions" value="134"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167JH61"/>
    <dbReference type="GeneID" id="29004540"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_86149"/>
    <dbReference type="InParanoid" id="A0A167JH61"/>
    <dbReference type="OrthoDB" id="5553750at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19527">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000109">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000039">
        <property type="entry name" value="peroxisome biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056995">
        <property type="entry name" value="PEX6_4th_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047533">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF9">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23315">
        <property type="entry name" value="PEX6_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="269"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="554"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="822"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="822"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD65977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="846" mass="92548" checksum="6FA1550141785BDD" modified="2016-07-06" version="1" fragment="single">DTESRVFVNIKDLGRCGVFSGDWVLVAANDSSKSRLCRIYGIDNNQEQAKRYIYIYIYVCVCVDLDVLFLSPILYFNLGLPLPPSSMEDHVVTITRLTVNPNPPMASAVTIARIASPSSMDKSLQTAFLEALKQWFEVRERIVCKGDILAIPLDEENARLRPKEEDEQADAFVRKPTTLAYFKVTSLEEPTESNGVHPSYYGHGRKIIPSQTKMIQTGVEQSRIPAGHLSRYYDFLSQLPLERSSTSAYCNLHELVSSSLHPLGRDFELSCNVLLLGPRGGGKATMVKQVAEALGVHLFEFATYDVVSETDAKTEAHMRAKFEKASALAPCIVLVRGIEALARKTAVVETGQEPLLATVLQECIKSVNSAYTSSGYPVMVVATTSDIDALPTSILACFRHEVSVEAPDEKTRLSILKNLTSSCPLAPDVSLKSLATQTAALVSKDLVDLVARTGVLALQRIHKSVYGAERNGARTQDIKAAGVALTAADFDGALNEARASYSDSIGAPKASDPKCIPNVTWDDVGGLANVKDDILDTIQLPLEHPELFGSGLKKRSGILLYGPPGTGKTLLAKAIATSCSLNFFSVKGPELLNMYIGESEANVRRVFQRARDAKPCVIFFDELDSVAPKRGEKGDSGGVMDRIVSQMLAELDGMSEGGEEAGVGDVFVIGATNRPDLLDPALLRPGRFDKLLYLGVSETHESQLRIIQALSRKFRLHPDLDLARVAEKCPFHYTGADFYALCSDAMLKAMTRVADTIEDKVKELNKEKRKGLPDVVTAQYYLSHLATPEDIVVQVEEVDFVKALEELIPSVSATELAHYSKVREKFEQPKNDKGKDKGKGKGKQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JTC4</accession>
    <name>A0A167JTC4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">60S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_42115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441001">
        <property type="protein sequence ID" value="OAD66668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284708.1">
        <property type="nucleotide sequence ID" value="XM_018440173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JTC4"/>
    <dbReference type="FunCoup" id="A0A167JTC4">
        <property type="interactions" value="327"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167JTC4"/>
    <dbReference type="GeneID" id="29001079"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_42115"/>
    <dbReference type="InParanoid" id="A0A167JTC4"/>
    <dbReference type="OrthoDB" id="1611972at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000079">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1430.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD66668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="44031" checksum="D869B27902BF0CC1" modified="2016-07-06" version="1">MSHRKFEAPRHGHLGFSPRKRTRSHRGRVKAYPKDDAKKPVHLTAFLGYKAGMTHIVRDLERPGSKMNKKEIVETVTVIEAPPMVIIGVVGYVETPRGLRSLTTVWAEHLSEEAKRRFYKNWYRSKKKAFTKYAKKYSEGAKDVTRELERIKKYCSVVRVIAHTQVGKARLGQKKAHLSEIQLNGGNVSQKVDWAREHFEKEVTVGSIFEQDEMIDVIGTTKGHGFEGVTHRWGTKKLPRKTHRGLRKVACIGAWHPSRVMYSVPRAGQRGYHRRTEMNKKIYRIATGSDKKSGSTEYDVTEKVITPMGGFPHYGEVNEDFVILKGSVSGAKKRVLTLRKSLTVHTKRSALEKVTLKFIDTSSKFGHGRFQTPAEKAQFLGPLKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JX98</accession>
    <name>A0A167JX98_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor CBF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_137153</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441000">
        <property type="protein sequence ID" value="OAD66856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284896.1">
        <property type="nucleotide sequence ID" value="XM_018429842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JX98"/>
    <dbReference type="STRING" id="763407.A0A167JX98"/>
    <dbReference type="GeneID" id="28990748"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_137153"/>
    <dbReference type="InParanoid" id="A0A167JX98"/>
    <dbReference type="OrthoDB" id="653904at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22906">
        <property type="entry name" value="HFD_DRAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000036">
        <property type="entry name" value="CBF/NF-Y family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF5">
        <property type="entry name" value="DR1-ASSOCIATED COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="8"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="105"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD66856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="144" mass="16148" checksum="FE183FBF5F979163" modified="2016-07-06" version="1">MKKKYKTKFPVARIKKIMQLDEDVGKVAQATPILISKALELFMQSLIDQACQETRTRNAKRLSAAHLKKTIETVEQFDFLKEVVANVPDPSAMTTAPLVASDTAVTPMEDVKEEAVTRPSRSRKAKTAAKVKQEAKEEEDEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KCD0</accession>
    <name>A0A167KCD0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_151273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440998">
        <property type="protein sequence ID" value="OAD67746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285786.1">
        <property type="nucleotide sequence ID" value="XM_018432645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KCD0"/>
    <dbReference type="STRING" id="763407.A0A167KCD0"/>
    <dbReference type="GeneID" id="28993551"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_151273"/>
    <dbReference type="InParanoid" id="A0A167KCD0"/>
    <dbReference type="OrthoDB" id="2439011at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="213" mass="24057" checksum="D85BD8748B6B3E7B" modified="2016-07-06" version="1">MPGPKEAKTSEINHYLYPLVMEHNQLYGGVVMPTIQCSSGALVRAALLLVACNIPAAHKTCGFISHSSTCACNKCNQQFPRLPDSNAVDYSGFVFSEWVSRTDAENRCDAKLWRMASSDAQRKRLERENGVRWSELHDLVYFNLMECTVINPMHNLYLGTAKRIIEKWRSSGLITDAHLAKMQLDADKLVLPEDYMPLETKIGRGFPFMKADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KJY7</accession>
    <name>A0A167KJY7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_173272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286306.1">
        <property type="nucleotide sequence ID" value="XM_018436981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KJY7"/>
    <dbReference type="GeneID" id="28997887"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_173272"/>
    <dbReference type="InParanoid" id="A0A167KJY7"/>
    <dbReference type="OrthoDB" id="2214613at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026960">
        <property type="entry name" value="RVT-Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13966">
        <property type="entry name" value="zf-RVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase zinc-binding" evidence="1">
        <location>
            <begin position="451"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="609" mass="68589" checksum="AD5BA77E4F47F268" modified="2016-07-06" version="1">MLGDFNYSSYAKASRAGLAPRLWLHFVANHFVDCVTLSDAQPMPTFHRDLSSSTIDYIYASKDIASCHSSSTVTFVQPLWTDHCLVRTCLSFPMLSHIGRGLWRANPRLANIPSFRSSLSDCLSSFIPLLSPSISPQSQWDLIKVEVARFTRSYSRTTRPSLATLELWHVLRVVTVPLSFFRRLRSIMSKFIQYRSFPPISLGTFCQPIRLGGLGVLDPQVQQAALQLRWLRPLVRSPLSPSGLVPPWFSYVLRLDSSSADPLVPLIFPSLRSSHQRDFDSPLATLLAAIDLLPHNFSDVVVNLPTCLSLPLSYLTTAQPDHPPFPSAWRDLRVSDAYEVDPSFGVLAQRPLHRILRRPIVLHQFFERLYTRSLVLHPVLYRATIPPAICAIQFPSLDMPSGTAVDVRPFLTALVPGIPWHRLSTQSFRLLCNFHSKSARPISPTLVPRQLRRFWSFPLPHGARNVWFRALHKNIPCRSRLNSRIPTAFPDPSCALCSHPLDNQTHFLFQCPVKLSVWSSIWTLYFAQTATPTVLLSGLQSFTFPPCTDSSLSAASIFGCTLLAIWRHHWLFIFDHVPFVSSAAFSTASSLLDRLKSELALDFPPPPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KR45</accession>
    <name>A0A167KR45_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Methylenetetrahydrofolate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="11">1.5.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHYBLDRAFT_136272</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes oxidation of cytoplasmic one-carbon units for purine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.15" evidence="11"/>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286726.1">
        <property type="nucleotide sequence ID" value="XM_018429774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KR45"/>
    <dbReference type="FunCoup" id="A0A167KR45">
        <property type="interactions" value="472"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167KR45"/>
    <dbReference type="GeneID" id="28990680"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_136272"/>
    <dbReference type="InParanoid" id="A0A167KR45"/>
    <dbReference type="OrthoDB" id="41403at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004487">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01079">
        <property type="entry name" value="NAD_bind_m-THF_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000255">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000012">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035812">
        <property type="entry name" value="m-THF_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="13">
        <location>
            <begin position="10"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="14">
        <location>
            <begin position="143"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00053076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAD68686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="312" mass="34790" checksum="EFB79EC08122E028" modified="2016-07-06" version="1">MPASCKTILASRVSASFRDQIKQDIKERNIRPKLVGFLANEDPAASKYAEWTAKTCAETGVEFELRKVDKNDLEEKITEANEDKSINGIMIYYPVYGGKQDLYLQSCVSTLKDVEGLCHKFVYNVYHNIRYVDDNETMKCIIPCTPLAIVKILEYIGVYNSVLPYGNRLYGRTITVVNRSEIVGRPLAALLANDGAKVFSVDVNGIQVFTRGTGIKLSAHKVEDVDLSVEEVVSQSDVVITGVPTPKYKLPTAYLKDGVIAINFSSFANFEDDVKTRASIFVPSVGKVTVAMLERNLLRLHDYQNNLTEKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L208</accession>
    <name>A0A167L208_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_149801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287449.1">
        <property type="nucleotide sequence ID" value="XM_018432340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L208"/>
    <dbReference type="STRING" id="763407.A0A167L208"/>
    <dbReference type="GeneID" id="28993246"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149801"/>
    <dbReference type="InParanoid" id="A0A167L208"/>
    <dbReference type="OrthoDB" id="5289248at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="38867" checksum="593B5CF14AA79B3F" modified="2016-07-06" version="1">MSVSAAFEQYVRNRLQRIHQQAQGGPPYCRPYIVPQKRPRISYNRLNLYWMQDSMCIYLFHFSLKEIQMISSTLGLPSRCEFGHLKVESDFGFAVLIHRYISGRSLKDLSLLFGMSPTSISTVCTGMQNLIYDKIKWGIQFDTRQFSPANLEIFSEAILAKGASFPNIVGFIDGLVKENSYAKGEVDFTRDYYNGWKHFHSVKFQSIVTPDGITNTLIGPFVGRKKGLSHYTTDNAEKRIEKYLQLSPNREDWFAFYGSPAGIECANIFKPFDSETKDDIEIKSNRCMAKNMLHCVNRTKRHTSTFFNVPPPKLEDYIAGLMRGKIEGEDEDDPLIVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L3N7</accession>
    <name>A0A167L3N7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_66256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287559.1">
        <property type="nucleotide sequence ID" value="XM_018441614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L3N7"/>
    <dbReference type="STRING" id="763407.A0A167L3N7"/>
    <dbReference type="GeneID" id="29002520"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_66256"/>
    <dbReference type="InParanoid" id="A0A167L3N7"/>
    <dbReference type="OrthoDB" id="2206543at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="344" mass="37942" checksum="2131F13FA48604F6" modified="2016-07-06" version="1">MSPKGSTNTNVFKTVPPQQSRLAKSSADQMFCDPENTRLKAILDEALARAAIHEEQQKVLLSKIDVIVAHSIALQEQNSTLTEELRVANEHVEFLHNQLQLQVQVPGASTFITTTLPPTEIAPVENSSAEASAHGPVTIPTPSPTTFLAAAKKAMGKKPNQPKLTTAQATRALQPESGPSAYAFVYLPCRHHLKYSQVRKLLRTFKIQQSRVLDIAFPERGTLSLLVHNDFKDKITQLFADIGVSVKTDFDPLDHRIIADPAHAHKPVQERQQLAYKLHRQRLLALCLRLPAPLGKSVMRHFCTVESSSLRLPPVCLEQYLEDRNLPSGPQASAIDTATAMVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L493</accession>
    <name>A0A167L493_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_66210</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the sal C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287605.1">
        <property type="nucleotide sequence ID" value="XM_018441604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L493"/>
    <dbReference type="STRING" id="763407.A0A167L493"/>
    <dbReference type="GeneID" id="29002510"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_66210"/>
    <dbReference type="InParanoid" id="A0A167L493"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051565">
        <property type="entry name" value="Sal_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233:SF84">
        <property type="entry name" value="FI23031P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233">
        <property type="entry name" value="SAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD69565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="211" mass="24369" checksum="AFFDE89BDD343111" modified="2016-07-06" version="1">MPSHCPSMNCTDQQHETNSQHGHVHIPCSEMIQRQKIAVLYQCKVCEKYFNRPSALQTHSYTHTGERPFACDSEGCGRRFSVISNLRRHIKVHKKNRPELQRNSRAYSHKRYQNVQRLMEKTACAPCVNNKQYLEPPICFQYNGAPAYMQLPPLLLRQLKRKQDFMDDPCSLATAQPGEIQLPPHNSRLFPSPFTLNQTFGKLSECSNNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LGV3</accession>
    <name>A0A167LGV3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Chitin synthase</fullName>
            <ecNumber evidence="2 7">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_115148</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chitin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 7"/>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288467.1">
        <property type="nucleotide sequence ID" value="XM_018428439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LGV3"/>
    <dbReference type="FunCoup" id="A0A167LGV3">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167LGV3"/>
    <dbReference type="GeneID" id="28989345"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_115148"/>
    <dbReference type="InParanoid" id="A0A167LGV3"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF38">
        <property type="entry name" value="CHITIN SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="692"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="732"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="8">
        <location>
            <begin position="15"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD70427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="765" mass="86630" checksum="09304DC72ED6112F" modified="2016-07-06" version="1">MVGGFVNPSLPRKTTTVELVNGNLVLDCPVPARLLEASARKDKEFSQMRYTAVTCDPDAFATSGYTLRPQCMQRQTELFIVMTMYNEDEVLFCRTMHGVMKNIAHLCSRSRSRVWNAEGWKKVVVCIVADGRQKCDPRVLDVLTTMGIYQKGVAKNMVNDKPVQAHLYEYTTQLSIDSDMKIKGAEKGIVPVQTLFCLKEQNAKKINSHRWFFNAFGTVLNPNICVLLDVGTRPGNTSIYHLWKAFATNENVGGACGEICVMKGTACLDLLNPLVAAQNFEYKMSNILDKPLESVFGYISVLPGAFSAYRYAALQNDAYGNGPLQKYFLGEGHENSGDSDIFTANMYLAEDRILCFELLAKKHQKWVLKYVQSAFGETDCPDQLPEFISQRRRWLNGSFFAAVYSLYHFQRIWSTNHTMSRKLALTLEFIFNFISLIFSWLGMANFYLTFYFVTKSLTSPEMDPFGGGWGNIMFQLLRGLYMFLLVVAFICSMGNRPQGSKWMFIISVMAYSLIMTYILFAGGWMSYQSIRHGTESEEWNKEGAMGNILIMMRQSNFCNVVVSLASTYGLYVISSLLYMDPWHMFSSFLQYLLLLPTYINILNVYAFCNTHDVSWGTKGDNTLQMDLGVAHTSTNEKGIEAVEMELSYSPDTVNAYYENALINLQQKPEIIRESRPPKTKQDDYYKGFRTRLVLTWIGCNALLVALITSGSLQSLLPSYNVDTAKAYEEAVGISYTGFILWAVAAIGAFRFIGSLLYLILRCFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LHH4</accession>
    <name>A0A167LHH4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_70611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288509.1">
        <property type="nucleotide sequence ID" value="XM_018442305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LHH4"/>
    <dbReference type="GeneID" id="29003211"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70611"/>
    <dbReference type="InParanoid" id="A0A167LHH4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007889875" evidence="2">
        <location>
            <begin position="28"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD70469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="373" mass="41840" checksum="EAE93C5BD28E1C01" modified="2016-07-06" version="1">MSTGLAFRTFTIRWVVLLGLASLSVNALTVTHPFANTNIVAGEDTLVSWSDVNAGTTSILGAILLVRRSKRKNEPERNIQRASNLFKDPSGHHGTGGFDETDNIKDAQHLHHQSQIQNQSGGYTDYRQPQYPAYAEPNNNYADYGYGGDNGGGYYPPSVPIGRFENSGYHRQSNVVSPSPGPGQNQGQNRGIPYSPPMQTMPAPMQEYSSSRYQYTPQLQFQPQWQEQQNYYDYPNDPTGGMNEMPPSHNQQGFYYPQYDQYDPYLQQQQQQQPPLPQHSVVNQPMAMPGYAPQQQQYPIDSRSPEPIIVSQSPPPPGANSNISDARQSRMSSDQRNSFDQRNSSEQRTSMPEDQRRVMSPTRAAQDSSKLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LS78</accession>
    <name>A0A167LS78_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_171046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289027.1">
        <property type="nucleotide sequence ID" value="XM_018436485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LS78"/>
    <dbReference type="GeneID" id="28997391"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171046"/>
    <dbReference type="InParanoid" id="A0A167LS78"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="322" mass="36951" checksum="AC490B7B1022A698" modified="2016-07-06" version="1">MSRNLNNNSVNNAFGEEPSVGSPPRNTNDIRTIMLQHSQGTVSNQRPLAPKRARLNLEGDSSGRTRNIHDVYEKLDIMNGVLNTVLKNTSSEKAQATASNAVEQDMSPGRQPTLDQLLRDYLSEEKLYDQYNTNENKNSEGNRLVLKSVTDYLHHQEEGKKVDLPTLRTKIVRHIGNRKLQEKKTEEKKQEENRRACLCQQCSCERRQSALKANRAHFVNSFGENVDSILHADYVSDLESDDEREEEEQDSSSENSFFLEILPKLEKRRGIGDRFVDELDVDYEAAHDKKNNTHPFEHKFKGIRDKQLSKTKANKLPSWSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LU81</accession>
    <name>A0A167LU81_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CST complex subunit CTC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_66594</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289149.1">
        <property type="nucleotide sequence ID" value="XM_018441662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LU81"/>
    <dbReference type="STRING" id="763407.A0A167LU81"/>
    <dbReference type="GeneID" id="29002568"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_66594"/>
    <dbReference type="InParanoid" id="A0A167LU81"/>
    <dbReference type="OrthoDB" id="2314520at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990879">
        <property type="term" value="C:CST complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045740">
        <property type="term" value="P:positive regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029156">
        <property type="entry name" value="CTC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042617">
        <property type="entry name" value="CTC1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14865">
        <property type="entry name" value="CST COMPLEX SUBUNIT CTC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14865:SF2">
        <property type="entry name" value="CST COMPLEX SUBUNIT CTC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15489">
        <property type="entry name" value="CTC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0779">Telomere</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD71109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1108" mass="126311" checksum="639CD69F657BD795" modified="2016-07-06" version="1">MIIQLVHELLAQNQSTSSSLSKAYIVARIQIVPNDNNFSCPIIQLVDPTTHQNVKCQVDQINPYSNNQIVCLRQWTWTILTDGSVFVGFIWDPSCLDGLDVIMQKHTARCQKLLNDSIIYRPLQLRKSNQLAVLNISGKVSAISGVYQRKAGSIPCYFVELEDEDYTLCVWFLGKEFIKYYWDFRIGNYYVFSDVQVATLALNQTKRGILRYIPIQSKYFCITQYQGQILENAAARIPSLTEHTSVFPPAVWLKSDADDSHTYEGVITRAIDSVLGIYEIDHQYTLCLFHSARLSLPCHPKTRIRLHHIHSVQIQADNSLLLNNHWKSPFSSDAPKTYSFLIACPRSRIEILSIPIYTTASEIPLDMKACSMNSLDQSSFDENMNFMQLLQTLEFKWTLYYYQLFMSISMSPNALLQATQNYASTLLSQDHNEAADQKLSRFTSFLEFNQFCNAVPSSRNAKFSLQTYPSIEKLKKLGSQKSQSKYSPPLSDLNIQHASFEDCPIIGVVDAFSDGQLCLKDGTGYIPLLVVYPKDHSRDIILIETLCIIRRFDYINEETSFKNSSGNACKTENIYLTCYIEDVDILFTGQSHLLTNLPDASVINSFLDHFKAEEKDDVLTILHIRNIQPTRAVFSSKNTVVLESHIIAICYDVIHPDSTCQTVSPHFVTLVLSSERDSLYQLAQFHIGRWMASSYKNPRQSLWRVGSKMKIVPIATNTSKIHIVPVLNPILHFKVPKIYDVKGIQKISAQYNSEYSGKHIQKTINLIGLVVYKEYVSSRDSLMPENRQRIWELYKTHRVGCPQMTSHSILVRLRSGLSTFDIYINLGLQIMPLGVIPGSVVLFTNLGLKPKRQGSVIYGFGTTCTYFTLIETSQDLNISVDQDIPTYMLGESVPEQRRLFKAVCHIKLLKLHMQWICKTCGLCAMADKCGGLCDDARAVFKVKMTLEVRDGTAACLSYTEDESLLFLLWGCSQSQRNNIKQQVFSSGEPFSYNSLDKYQEQSQLEKLCLKNNTPGRYWVYGYFLTNGDMEGLPGFYFSRMIKTVHLEPITNLSDSKVKAPFEYPTFVSSSLCDQYKVFRLIPYAVQNNIKEIYQLTERINKHYIKGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167ML90</accession>
    <name>A0A167ML90_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_65772</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291214.1">
        <property type="nucleotide sequence ID" value="XM_018441530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167ML90"/>
    <dbReference type="FunCoup" id="A0A167ML90">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167ML90"/>
    <dbReference type="GeneID" id="29002436"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65772"/>
    <dbReference type="InParanoid" id="A0A167ML90"/>
    <dbReference type="OrthoDB" id="10266074at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07978">
        <property type="entry name" value="HFD_TAF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD73174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="129" mass="14875" checksum="9B62C286D18E9F7A" modified="2016-07-06" version="1">MSESREQKDLVKEHREPGTGPGRRKTVRKGMFAKDLKLLMYGFGDVQNPAADSIAVMDDLVIDYITEMCLKASKVAENRGKVRVEDFKHILRKDAKKLARVEELIYMSEDIRRAKQLFDEKEMDPAEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MYM1</accession>
    <name>A0A167MYM1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_177484</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292574.1">
        <property type="nucleotide sequence ID" value="XM_018437892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MYM1"/>
    <dbReference type="FunCoup" id="A0A167MYM1">
        <property type="interactions" value="713"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167MYM1"/>
    <dbReference type="GeneID" id="28998798"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_177484"/>
    <dbReference type="InParanoid" id="A0A167MYM1"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000086">
        <property type="entry name" value="Ras-related small GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD74534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="207" mass="23368" checksum="F561015DE3D028AB" modified="2016-07-06" version="1">MSDRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSSQYKATIGADFLTKEVLVDDKLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVYDVNNNKSYESLGQWHDEFLVQASPRDPENFPFVVLGNKVDMDESKRMVSQKRAMAFCQAKGNIPYFETSAKEAINVEQAFQTIAKNALQQETEVELYNDFSDSIRIDQDSDKDYSGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N038</accession>
    <name>A0A167N038_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-arabinitol 4-dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_132811</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-arabinitol + NAD(+) = L-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16381"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17399"/>
            <dbReference type="ChEBI" id="CHEBI:18403"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.12" evidence="8"/>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292684.1">
        <property type="nucleotide sequence ID" value="XM_018429522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N038"/>
    <dbReference type="STRING" id="763407.A0A167N038"/>
    <dbReference type="GeneID" id="28990428"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_132811"/>
    <dbReference type="InParanoid" id="A0A167N038"/>
    <dbReference type="OrthoDB" id="2148442at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050019">
        <property type="term" value="F:L-arabinitol 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF12">
        <property type="entry name" value="L-ARABINITOL 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="22"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD74644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="365" mass="39745" checksum="8E5BC392C6C9C954" modified="2016-07-06" version="1">MSALNYNPSTYEIPGKNTLNHGVLLNKKDDLKIVELPIPIPEEGEVQIQVKATGICGSDIHLWKYGEIGIFPVTTPQLLGHESAGVVTAVGKGVDTLKVGDRVAVEAGIPCSKCDQCMSGRYHLCPTVIFKSTPPHHGQLAKYITHPARWLYKIPDNVTYEQGALLEPLSVAISAIERVGVKFGRSLLITGAGPIGLIVLAVAKATGISPIMITDVQPSRLEYAKKMGADFVYQVDPKRKDVEIAREIRDIFGGEGAEYSLECTGVESSFRTAIMATKDAGVCCLVGVGKNDQLLPVNNFAMREVDIRGLFRYHHTYPRAIALMASGNLKIDHLITHRFDFKDALKAFDTTADYSTGAIKVQILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N6L5</accession>
    <name>A0A167N6L5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_186671</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD75144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293184.1">
        <property type="nucleotide sequence ID" value="XM_018439267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N6L5"/>
    <dbReference type="FunCoup" id="A0A167N6L5">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167N6L5"/>
    <dbReference type="GeneID" id="29000173"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_186671"/>
    <dbReference type="InParanoid" id="A0A167N6L5"/>
    <dbReference type="OrthoDB" id="7305308at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000064">
        <property type="entry name" value="GNAT family acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD75144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="166" mass="18694" checksum="0FF4EA2324AD943E" modified="2016-07-06" version="1">MSPIDIRPATPADAGLIVKFIKDLAEYEKLAHEAVVTEELILKNLFGERPYAEVIFAYCAKAPGEEKVPAGMALFFHNFSTFLGKPGLYLEDLFVKPEFRGLGVGKRLLVQLAALAKERDCGRYEWVVIDWNEPSRKFYEALGAVPHQEWIIHRVEGKSLDDLAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NIA3</accession>
    <name>A0A167NIA3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_59501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294010.1">
        <property type="nucleotide sequence ID" value="XM_018440509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NIA3"/>
    <dbReference type="GeneID" id="29001415"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_59501"/>
    <dbReference type="InParanoid" id="A0A167NIA3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="144" mass="16444" checksum="B29C5A620691E333" modified="2016-07-06" version="1">MNIEIEINDVEEYSEENSEECVETLIWTSLKNLKSLKNLMVSNKKINYQIDHYYLLNMLEDSNLAFIASFVTTFISKYVVNSGGVILLKFINEVLAHFEQSFHLPLSLSGFNSITGINLLTRDLYCYVACSECNSIYFESASVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NWN4</accession>
    <name>A0A167NWN4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_109354</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294804.1">
        <property type="nucleotide sequence ID" value="XM_018428109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NWN4"/>
    <dbReference type="FunCoup" id="A0A167NWN4">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167NWN4"/>
    <dbReference type="GeneID" id="28989015"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_109354"/>
    <dbReference type="InParanoid" id="A0A167NWN4"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF81">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="53"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD76764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="492" mass="55185" checksum="67C682FE42BC3015" modified="2016-07-06" version="1">MSVSKYPLETITTNRRDSFTSLNESDTSLIYTKYDRPISVEEKALVRKIDWCVLPLICLVNFLQFLDKSAINYANALGLQVDTGLVGDQYSTIVSLFYLGYLSYQLPNNYLLQHVKIGRYIGVLLVAWGSVLAATASANNFSHLAALRFLLGFTEGGVYPCLILLVSTLYRRSEQTSRLGAFWLCNGLALCAGGFISYGIGKIPYILGLHPWRWCMIILGGVTILVGFICFFFLIDDPRSLKWRHNAEEQILVEERIRDNAVVRTNKVNFAQIKEALLEPRLWCFCFISFLINIQNGALTSYSTTITQGFGYTNLDAILLQTPTGIVDVTYIILAAYVSQRTGQAIYVGCFCLACTALGLLLLEFIPIDKYKLVGFYICWGYAAAYVMLLSAATTNVSGFTKKIFYNGLIMIFYTAGNFTGPYMMVSSQAPNYIGGMMGYVGADVLAITLFLIARWQMARVNKRRLSEPPAECINTEEDMTDKQDDNFIYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NXJ1</accession>
    <name>A0A167NXJ1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_165332</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294868.1">
        <property type="nucleotide sequence ID" value="XM_018435202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NXJ1"/>
    <dbReference type="STRING" id="763407.A0A167NXJ1"/>
    <dbReference type="GeneID" id="28996108"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165332"/>
    <dbReference type="InParanoid" id="A0A167NXJ1"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="30"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="32"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD76828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="193" mass="22563" checksum="E197320BEFAFFD85" modified="2016-07-06" version="1">MNSPPDNCLEFKDDEAKKRQSLRIKSHEAPLAKPKRKRISPDQFRVLSDLFEKTDTPNYELRERMAGRLNMTNREVQVWFQNRRAKATRAKILDSPRRIKHRPDPLLVYPYSKPVFYAKPITPDEDEPERLSPCNTSCSSLSSIATPTFNMSPIDLLATAAEYVQRCDDEKRQAQEAAQQRRSEESRSWRPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P7Z7</accession>
    <name>A0A167P7Z7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_179856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295474.1">
        <property type="nucleotide sequence ID" value="XM_018438223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P7Z7"/>
    <dbReference type="STRING" id="763407.A0A167P7Z7"/>
    <dbReference type="GeneID" id="28999129"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179856"/>
    <dbReference type="InParanoid" id="A0A167P7Z7"/>
    <dbReference type="OrthoDB" id="47730at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016423">
        <property type="term" value="F:tRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14911">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14911:SF13">
        <property type="entry name" value="TRNA (GUANINE(6)-N2)-METHYLTRANSFERASE THUMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="1">
        <location>
            <begin position="220"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD77434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="410" mass="45149" checksum="E7F8D1AB34665D16" modified="2016-07-06" version="1">MSNPQSLHVVLHVPEGLEFVAVDDIKESLKGKITEEATFLSEPKTGRVHLMVQTTKPSQIIQSLKSATLLSVYSVTLVVSETNIPQSTFDDPQLTYDFTNDVTLASPWENALEAVSIASGSNSSDLAPTFRATFHKGQLKNSAQSQKLAGYIGFAFSQRHPDWKVKLTEYDQEVVALWFRSTEKAMLERLASCADHGEDGPIVLLLGLTIPIKDPKYRNRVHVGRTSLNPCIAYCLARLADPKPGQVILDMCCGTGTIPLEGASKYPSTMWIGSEVNLRTLCVKAKGNLEHSGVNNVDLMVGDGRCLALRSGCIDTVVCDWPWGLREGSYSAIQKLYPKFIKQIGRVLPTHGKALIVTQGQKLFNRVLAYSWSKDMWTTDSIIPIGIGGYDVYLYILIKKEPKPSAETTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PE77</accession>
    <name>A0A167PE77_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_60869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295787.1">
        <property type="nucleotide sequence ID" value="XM_018440709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PE77"/>
    <dbReference type="GeneID" id="29001615"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_60869"/>
    <dbReference type="InParanoid" id="A0A167PE77"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="113" mass="12342" checksum="9160CFE875F209BD" modified="2016-07-06" version="1">MTFVFCAILPSRGVLLCAVVRLCAPLCTFVYLCAFLCLWAKACEIVYTACVLNIPQPQGWSPRLDPSPADVSLFEANAGFGESSHSRMAVMPQLGRYCLRESLKLASRGVPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PG70</accession>
    <name>A0A167PG70_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_141719</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295894.1">
        <property type="nucleotide sequence ID" value="XM_018430650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PG70"/>
    <dbReference type="GeneID" id="28991556"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141719"/>
    <dbReference type="InParanoid" id="A0A167PG70"/>
    <dbReference type="OrthoDB" id="10387665at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007891143" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="39"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD77854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="162" mass="17842" checksum="ABA1BF997B2C7044" modified="2016-07-06" version="1">MKFLFLSVLIVLTSAAVVLGVPVPPSTGSDALSIKINLPQPGTVWNAGSFQHIDWKNPQDHASYYNITLYKGEKIPNAYERVLVKDIAADLEFARIHVSEDVVPGDDYWIEIGSGKLKTFVKYLTIKAADSSYNDSSEGSDYPSSEELQKINELPLFGSNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PNK0</accession>
    <name>A0A167PNK0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like modifier HUB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_107936</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296299.1">
        <property type="nucleotide sequence ID" value="XM_018428021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PNK0"/>
    <dbReference type="FunCoup" id="A0A167PNK0">
        <property type="interactions" value="362"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167PNK0"/>
    <dbReference type="GeneID" id="28988927"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_107936"/>
    <dbReference type="InParanoid" id="A0A167PNK0"/>
    <dbReference type="OrthoDB" id="3881at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01791">
        <property type="entry name" value="Ubl_UBL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000052">
        <property type="entry name" value="Ubiquitin-like protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039732">
        <property type="entry name" value="Hub1/Ubl5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13042">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD78259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="73" mass="8531" checksum="7281F1CBCC042BFD" modified="2016-07-06" version="1" fragment="single">LIELEVNDRLGKKVRVKCSPSDTVGDFKKLVAAQIGTEPQKIVLKKWYKEFKDHITLSDYELNNGMNLELYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PQP6</accession>
    <name>A0A167PQP6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_140462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296404.1">
        <property type="nucleotide sequence ID" value="XM_018430404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PQP6"/>
    <dbReference type="GeneID" id="28991310"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_140462"/>
    <dbReference type="InParanoid" id="A0A167PQP6"/>
    <dbReference type="OrthoDB" id="5279943at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="307" mass="35109" checksum="DDA2A740F08193AB" modified="2016-07-06" version="1">MSASIEPTPNSALETDDSNNMYGPVHSVAIHGQSVSPNILVALLNRPREMQDLAVRNSFFYEAIENYIRDTQGDSSWDSFQHIVYAPREEMSDRVWMASITDYLGHHPAFLGKFKESVGYQSSSSEDEDEEDGDDETEDDDEDDEVVETRKRAPKLTLQPYPRRHSHNHVHYHPMQSEPHPSITSPTLREEEESRGSEEGGLVAGLVALRAHPDIQVQLPERYPAFFQRARRCMGSCIMSMDTPRFQTADTSEDSFEPFITLISTTRRQQPDDGAWMESILEILKCWPELIDELSDIIDDSLPRRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PS45</accession>
    <name>A0A167PS45_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_163549</name>
        <name evidence="1" type="ORF">PHYBLDRAFT_173922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD68012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286052.1">
        <property type="nucleotide sequence ID" value="XM_018437136.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296478.1">
        <property type="nucleotide sequence ID" value="XM_018434825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PS45"/>
    <dbReference type="GeneID" id="28995731"/>
    <dbReference type="GeneID" id="28998042"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_163549"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_173922"/>
    <dbReference type="OrthoDB" id="3247418at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="384" mass="44152" checksum="4963BA15B7A964EA" modified="2016-07-06" version="1">MDTWIANNLLDDKDFVEMQEETNRIVLPVGYTPLKIKIGKKFPFMKADEWKSWCLIYSPVLLKTCLELTKSSITKNGIKKAHERLEEFCVGCEDFYKPDVFTQNMHLHLHLKEMIEDFGPIYGFWLFSFERYNGVLKGFETNQKSGFKNTYMKRFLESSYNGNFCQGHLRNVTSSLLLSLFLKLSGRKIYNPALSPHPLIPSFFHLPTFLQSAEKPSKQTFGNEPLPLSTLPLCLKLPTTIRKSEYDCLLDFYKIEYDDDSLCSAKTTIRNYWFVNDQIQKISSINLLGQFYTGGEGLVVRGLHIQVKFIEKSGDSEERYAGCIKYLFLLKHGIELYEPAFLKYDYNNILPVHRILSPIAIGSHVSGSGAAKVVVIPLPRKLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PTU7</accession>
    <name>A0A167PTU7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_163636</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296567.1">
        <property type="nucleotide sequence ID" value="XM_018434848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PTU7"/>
    <dbReference type="STRING" id="763407.A0A167PTU7"/>
    <dbReference type="GeneID" id="28995754"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_163636"/>
    <dbReference type="InParanoid" id="A0A167PTU7"/>
    <dbReference type="OrthoDB" id="79252at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061188">
        <property type="term" value="P:negative regulation of rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061186">
        <property type="term" value="P:negative regulation of silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053051">
        <property type="entry name" value="HDAC_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="40"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="102"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="154"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="413"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="430"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD78527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="554" mass="61333" checksum="2D13A1FC741504D8" modified="2016-07-06" version="1">MASMAERSKNNNDDALIRLQKKAAQTADRSPDAFVEKLVSCVQACDKLLLTNKTWLTDNSGLMVQCDKCEVWQHCECVGLEEQDIPDQYYCEQCKPENHSVVRQTHGRTRRSYRSGGKAAVAADKKAPKKRMTLNSREASMPLEDVLAARNALESATKLSSPSDSPLASPIELPEELEDERRSVKRRRDDKEADSDCMDDEVIAAADIALKECTEKKTESPTELERPSTNTPSTTKPIKTKRSASVRNKTEDSAVAEKPKGAEKRGKREPANKRGNSTTSKRGQATKPRSRTSTPQPNEPIQPPVDIGASIFQHFSLEARAASPPARIRVPSARMSILDMNKRAKQILEYISTLQVEMANKDNSSVKKEHVHTTSKPWTPKTSDEGGDLLSSIEVTGISMEITREDIVAGVDSKRKKFRPDPISIPTQIDPDSPSSSLSSASTLPLDEPPPSLADIEKSVAEEAIERQDALIGNKTQSSLEIMDVLTRELIRFQRRFGSGSMSLQSRLNGSGSSMRTREEGRLVEIEGRTTRSRDMAISNNLRSLQDKRATYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PW62</accession>
    <name>A0A167PW62_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_107575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296684.1">
        <property type="nucleotide sequence ID" value="XM_018428004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PW62"/>
    <dbReference type="STRING" id="763407.A0A167PW62"/>
    <dbReference type="GeneID" id="28988910"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_107575"/>
    <dbReference type="InParanoid" id="A0A167PW62"/>
    <dbReference type="OrthoDB" id="546893at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17394">
        <property type="entry name" value="MFS_FucP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF3">
        <property type="entry name" value="PROTEIN TSGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD78644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="47328" checksum="BBD1DA647C7FF863" modified="2016-07-06" version="1">MPSYFIPGALVTVLFFLWGFSYGLLDTLNKHFQNVLHITTTQTTFMQVAYFGAYFVFSIPAGMISKRFGYKRAIIFGLALYVIGAIGFYPSAVTLQYGGFVASLFVIACGLATLENCANTYIAIIGSRKWAPFRINVAQAFNGIASAVAPVIASYAFFGGDEGATDSLETVKWTYIGVACGVFVIGVLFCFAKIPEVDEEAMMAAEALATGVTIRRASLASPHLLLGALAQFCYTGAQVCVASLFIFYGNEVGGFKDSYSSQLLSYGQLCFTVGRIFGAILLRKFRADHLMAVFSACASIINIFVIAMRTPKTTYSLLALLFFESVMYPTIFALATRDLGRNYKRGASMVIMGVGGGALLPPVQAAIKDSVGIHISFVIPLIAYVYVLFYAIWGCHIVRYVDEPVDVEEFGDGKPQISQIELESSSFEKTQVSHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PWG0</accession>
    <name>A0A167PWG0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_179634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296698.1">
        <property type="nucleotide sequence ID" value="XM_018438185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PWG0"/>
    <dbReference type="GeneID" id="28999091"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179634"/>
    <dbReference type="InParanoid" id="A0A167PWG0"/>
    <dbReference type="OrthoDB" id="2283394at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD78658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="321" mass="36317" checksum="665D3D12FD1C9A8D" modified="2016-07-06" version="1">MFMRLIILESDKNSRWIKAIGILLITFRFADWPYELAYNNIKDISTQIIGEGTTCWASWGNGVLIVNVIADTLATLFLSGMFVRRLYIHINTSKSFISQQNRTIEHIARKSLWCLVLTFVVNMVMNLLKVTSFLNDRSDAFTVYFELIESTLLVEALRFDQRKTGTGAFCDNCGMEIKYLPRQNNSSSSRSRSDRKYPDDDEYFHVTSIPSSRLDSNSQSISTRPAQTKETPKNQTLSFNIPENLRMQSSFENSVSHPGPVAFRETVSSPAFGPSDRAVMVSTNSNTTNTNANANANTNINTKIINYKPSNQTSSLPVRYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q5U1</accession>
    <name>A0A167Q5U1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_139152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297157.1">
        <property type="nucleotide sequence ID" value="XM_018430170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q5U1"/>
    <dbReference type="GeneID" id="28991076"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139152"/>
    <dbReference type="InParanoid" id="A0A167Q5U1"/>
    <dbReference type="OrthoDB" id="2223116at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="118" mass="13480" checksum="AE6050F32404541A" modified="2016-07-06" version="1">MDSITAAQRDKLAREVMREQAALETQRYEQELHRASVYSTASSATNGRRLSANRPMADPNAFMTNSEVNQFDRGVWQKNMSPSDRAKELASEMKAKQKMRGQVREKMVKVGDKVMRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q6Y1</accession>
    <name>A0A167Q6Y1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_179005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297218.1">
        <property type="nucleotide sequence ID" value="XM_018438078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q6Y1"/>
    <dbReference type="GeneID" id="28998984"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179005"/>
    <dbReference type="InParanoid" id="A0A167Q6Y1"/>
    <dbReference type="OrthoDB" id="21214at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="264" mass="29745" checksum="5829B4267E453553" modified="2016-07-06" version="1">MTEEDFLQKLWKVTNELASQHQTNQDFAGSLSSQLQDLKQRAVSTSNNGQEQAESTTTVPIDRIHSPLPSHVANDLSTSERQPKDLISDNYKLMQKYQAVLNRNQYLESECSNLQSLVKDYETNIEAVTIKLRSHANATTEGQSKLRREYEALLDAEKGTTAALFIENTTLQSRLHKLASMLRSLHDDGVNDEREALITQLTAENQGLRDMLHLPLIPQAEIPDQTSQLMKDMGTKEERVRVVSESGISGPSNVVEEYFVNDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q814</accession>
    <name>A0A167Q814_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_179041</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297287.1">
        <property type="nucleotide sequence ID" value="XM_018438090.1"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167Q814"/>
    <dbReference type="GeneID" id="28998996"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179041"/>
    <dbReference type="InParanoid" id="A0A167Q814"/>
    <dbReference type="OrthoDB" id="203724at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058541">
        <property type="entry name" value="Ig_TPPC8_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058538">
        <property type="entry name" value="Ig_TPPC8_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058540">
        <property type="entry name" value="Ig_TPPC8_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057651">
        <property type="entry name" value="Ig_TPPC8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24545">
        <property type="entry name" value="Ig_TPPC8_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24544">
        <property type="entry name" value="Ig_TPPC8_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24546">
        <property type="entry name" value="Ig_TPPC8_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24542">
        <property type="entry name" value="Ig_TPPC8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPPC8 first Ig-like" evidence="4">
        <location>
            <begin position="744"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="TPPC8 second Ig-like" evidence="3">
        <location>
            <begin position="952"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="domain" description="TPPC8 third Ig-like" evidence="5">
        <location>
            <begin position="1084"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="domain" description="TPPC8 C-terminal Ig-like" evidence="2">
        <location>
            <begin position="1340"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD79247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1478" mass="166129" checksum="9B8BEB1BA3CB0ECE" modified="2016-07-06" version="1">MPEKPLPVPLSPLLGIPTSPSPREHIARSLSPLIAIAASPDADEICQSNHIPSFADFIKPFGEHVQGRVTPRDSQGTPYAIDNFCVRFKAIDKLDEPNHRALMDVMDDHVRACGSDPAASDIVHIKSRSDVDDNYLDTSLDQLMPWYADFKHMMLSLRGITEHETFDHPVAVLIVISSANPDPMSTIMQLYNPNVPSFTIDKPYVDPNILRFYVLLHDPQQTTLEQSQIVFDKMKKTFGLHCHLLKLNSRPPPSDLFEDSIQHTDENNAIRDIWSQLPTSLNIESRLQARTSTLAGPEILSPNNSSFSTPLSPSPSGHRRSNSASSNTNSFTPPTHGTNLQNGPLDMSSPLEDGTRLPTHDMHLIGSAASPAMQYGRCLTVDDVQNTQFMIKELVVQSLVPFMERNVQHWNEQVASARRGITGRVFGAGRRFFGTSSRTSSPQSIQSIPATGPNTPVGTNTLTIFPYGAPEAQMRKLADYAFMLRDFKFAHAIYDNVRRDYATEKAYKYHAGTQEMIGVCQLMMNQPLSNKLDVDRNFELAVQQYLGRCRSSFHATRTTIMYYELLKARRMWKEVPTALVRMTGEDSDLRSALFLEQAAHCFLRTPSPMARKYGFHLVMAGHRYGKASQRQHAFRCYKLAAHIVEGQEWSVAKSHIQFALGRQAFHLGQLEDAVKYFTNVLADAKQMPQQQAAHIREFLFIYRQYTTQAGIDPLKEALPHLSLPVIDDNSTHVTLSNTQSNTGDNQEEWSTMEIELLEESIAKGYIAGSKKALAIQQQDDQRPICAVGEPFLVHISLFNPLQVAITISQLILGCKHRESLQHNTDTSTESDENVPMIYGAHIEGTNMYAFDDFELEKVSEIFLEPLEKRMISLAIIPRREGSIAVKGLHYTFNDLVHTFKPFHKKGKRLHSTREQLMTPVYAVDHTLDIIVTSPMPLLDLAFHGIPETILSGELVQAVLEINNKGNKGMTALRLKSSHPSFICIGNPEEMDKHVYAGESDSKHQKEEEIKFDNLLFDSSVISVPLPAEGGGKSNERGVVSPGKTTLVPLWIRGDRIGKHTFKFLFSYQSEEGNGAIAHRTLRYTVNLQVLPSLKINAFTRPSTTAVNEYILGIEIENLQVAANFQLNQISATSPVWTITPLSINIDSPQDIQAKTSIPPRQTTFAYYKIQKKAKQTEQSLCPEAWTSTALEALLNNIEYHEPPPPVDLHVSKLSFRDTVIPFNTVPLKMFALNSRVHWRNSNLQSQFPNISPEKYDTMFTLYNSSDVDLTIYWNIPNMKRHGHHYIIGVNLGIVQNPFQGQVTSSKGNSGRTMFEQTAKERATLLSSLTKNKVLKDESPVKLMVKTNDTINHDFEDEGLLGVPVDIVLKNCSWNKTATYTLELMSWTENKVAQSQKSAKPTLNIHPFHWTGATVFTGTLHPDETNTLEAQAIFQLPGVYDVNRWKLTIETSQYRDEHPDSTGYFVQWPSLPQIVTIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QBK7</accession>
    <name>A0A167QBK7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_139456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297467.1">
        <property type="nucleotide sequence ID" value="XM_018430229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QBK7"/>
    <dbReference type="GeneID" id="28991135"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139456"/>
    <dbReference type="InParanoid" id="A0A167QBK7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="61" mass="6850" checksum="29BF2F28E4FF1A00" modified="2016-07-06" version="1">MRQTLNVSQKASTEHKFVVQDLNSAEEQQNFLEVEETLDEDAPKGDIKNQSPETSTAEQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QM03</accession>
    <name>A0A167QM03_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_58944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297941.1">
        <property type="nucleotide sequence ID" value="XM_018440410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QM03"/>
    <dbReference type="GeneID" id="29001316"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_58944"/>
    <dbReference type="InParanoid" id="A0A167QM03"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD79901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="116" mass="12693" checksum="10C1BC0AE288F396" modified="2016-07-06" version="1">MTPSSLSPHYAAQSPSGRKPDLVAKEVLEWWQTNGKHPFIQPHISSPSNVGANSPENLPLGDKVQLIRLPVASPSAVKEFSQVSSEEPAHLTTGSGILSSRLSFIEMRYICRFLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R4G7</accession>
    <name>A0A167R4G7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_184459</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="763407.A0A167R4G7"/>
    <dbReference type="GeneID" id="28999842"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_184459"/>
    <dbReference type="InParanoid" id="A0A167R4G7"/>
    <dbReference type="OrthoDB" id="44015at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ANTH_N_YAP180"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ENTH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="4">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="268"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="402"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
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            <end position="309"/>
        </location>
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            <end position="428"/>
        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OAD80819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="533" mass="59227" checksum="A45C71BB97F8FE64" modified="2016-07-06" version="1">MEIAVRKATRLDYQPPKQKHLSTLISLTFQNPALIADMMDLLERRLRENSWIIVFKVLIITHVLMRDGNNERVMDYMGKHPSALDTSRLREKSSGVIQIQHIYVYTAYLAQRVAVYRELNFDHIQAIKTNKEGRLRHLTVAKGLLRETIALQKQLSALLKCKFHLEDTDNSISLFATRFLVEDLMVLFQVTNEGVVNILEHYFAMSKHDARASLDIYKRFARQTEEIIEFLNRARHLQSELQMSIPAIKHAPLSLAEALEEYLNDTERDGAPKQDTLKVSSPTVSSPKTSSPSNLATQSAFSTVQPPVVQENQRPTELIDFFSSLEKEQATVYYNQAGQASFNSSPTSLQPTQSFSPATMQSQHNPFRATMVQPQSFDPLTNLSSLPAGSLVQSPATITNANPFRSNTLPPPSSAQNSLSVLGSSFGSMTMPPGSINNNNNNTGGAGISFQGLQAQMTGMPAAQSTVQRSQTFSQFQTPLPTSQNAFNPFAHTTQQNTLDIAAPINPFGHPHTLQSLQKPTHMNASPWGSSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167RCI5</accession>
    <name>A0A167RCI5_PHYB8</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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    <organism evidence="1 2">
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            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018434539.1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="105" mass="12606" checksum="70620009702708B4" modified="2016-07-06" version="1">MLAPITSWAKVIKNSYLNPTNFWHGDLDEVPLNLPIDTQMYLFKARYSDMDGGQKFYHYHYIERVFFLLRELFSDISNAAYKNKLRARYSDTGGFKFYHYPYIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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    <name>A0A167RF60_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
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            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299547.1">
        <property type="nucleotide sequence ID" value="XM_018427891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167RF60"/>
    <dbReference type="GeneID" id="28988797"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_105249"/>
    <dbReference type="InParanoid" id="A0A167RF60"/>
    <dbReference type="OrthoDB" id="372722at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD81507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="117" mass="13652" checksum="8E289A12EB4F5D28" modified="2016-07-06" version="1" fragment="single">LTFTTQIKSTQIKSNQIKSNQIKSNQIKSNQIKSNQIKSNQIKSNQIKSKLKEHCIGTWLWIEATLRIGPRLSITISCKILFTYILAKRMKYFLKKNGLDWAGLDYHGLDYLIFYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N5W0</accession>
    <name>A0A162N5W0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Histone-binding protein RBBP4-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_119602</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441006">
        <property type="protein sequence ID" value="OAD66094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284134.1">
        <property type="nucleotide sequence ID" value="XM_018428695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N5W0"/>
    <dbReference type="FunCoup" id="A0A162N5W0">
        <property type="interactions" value="943"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162N5W0"/>
    <dbReference type="GeneID" id="28989601"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_119602"/>
    <dbReference type="InParanoid" id="A0A162N5W0"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="7">
        <location>
            <begin position="7"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="163"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="215"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="261"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="305"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="362"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD66094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="408" mass="46196" checksum="2B8840FFF409103B" modified="2016-07-06" version="1" fragment="single">KQREIDEEYKTWKKNSPFLYDLIYSHGLEWPSLTCQWFPDVESRPEKSYTIQRLLLGTHTNDEEPNYLQIASVQLPNSKQEIDMRKYEESTNEVGGHGATNDAHVKITQKIVHDGEVNRARYQYDNPNIIATKSKTGDVYIFDRTTHESFPRENERFNPALFLKGHTSEGFGLAWNPHHSKKSYLLSAGFDGLVCQWDINAASRDHRVLPPLRTFRGHSSSVADVAWHLGNDSIFASVGDDKRLLIWDGRHGSSDIPLHSVSAHDAEVNCVGFCPGNEWVLATGSSDTTAALWDLRNLRVKLHSLKAHTGDIVQLAWSPHHDAILATAGVDRRSIVWDMARIGDEQTAEEARNGPPELLYVHGGHKSRISDFGWNPASPWTLASTADDNVVQLWKMESDSFLFWKTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N877</accession>
    <name>A0A162N877_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exocyst complex component EXO84</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_134401</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EXO84 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290058.1">
        <property type="nucleotide sequence ID" value="XM_018429643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N877"/>
    <dbReference type="FunCoup" id="A0A162N877">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162N877"/>
    <dbReference type="GeneID" id="28990549"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_134401"/>
    <dbReference type="InParanoid" id="A0A162N877"/>
    <dbReference type="OrthoDB" id="642193at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1220">
        <property type="entry name" value="Exo84p, C-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1210">
        <property type="entry name" value="Exo84p, N-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033961">
        <property type="entry name" value="Exo84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032403">
        <property type="entry name" value="Exo84_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042561">
        <property type="entry name" value="Exo84_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042560">
        <property type="entry name" value="Exo84_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426:SF12">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16528">
        <property type="entry name" value="Exo84_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25345">
        <property type="entry name" value="PH_EXO84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst component Exo84 C-terminal" evidence="8">
        <location>
            <begin position="364"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="333"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD72018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="566" mass="64806" checksum="0547800097BF1863" modified="2016-07-06" version="1">MNPASVLRKKSNSSDAFKKKEKDKDRVAGRIGSPLAMNASSNTSAFQSGISVKPSSRAPPGINGTFASTAPIVIDLHRFADENMQPEEYVHRALGDANEEGIRAFHKSLIESKHVVGGDLQRNVYRNYTEFVAISKEISNLDGDVLHLKGYLNELRNIWEGFLASTDASNELLPTNDGVFSEPILPLRRRSELMTTDMQTIHRAQIVALWENVDGSQKFIPYAQDRQIVRECVNFVELDPRTGQPHQAVHIFLLNNCILVASRRKRSIANKYKLMAEYYWNLEDTTMLDIKDSPELQNSLKIVVYPNTYLFRADRPEDKLGLLHAYRRVMDEDNDKSQDQAKNGRSNNGRDNQQPTSLDPDDLKWLTELPDELEVLIAIREFENAVMLIEKARTIFKGYSADLAALRDIRTQVQKYTDLLCTTISNDLGNILLTKLQFQRFVGWLLRLDKGEQAREVFLATRSLIIKKRIRQLIFEGDIPTYIGELALVVFTLIRNTCEWYRDSFKQNDMASGFVNWVREQTNIYATIYKRQVFNNSHLSCQIISDCFKSTLDQCAIVRLAKTQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NIB4</accession>
    <name>A0A162NIB4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_67568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UreD family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292548.1">
        <property type="nucleotide sequence ID" value="XM_018441815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NIB4"/>
    <dbReference type="FunCoup" id="A0A162NIB4">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162NIB4"/>
    <dbReference type="GeneID" id="29002721"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_67568"/>
    <dbReference type="InParanoid" id="A0A162NIB4"/>
    <dbReference type="OrthoDB" id="5550464at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD74508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="40712" checksum="903053B65E09BD21" modified="2016-07-06" version="1">MKRFSSANTDIPGKGILVCQCHDRETRFSRIHAQYPLKFIPTKAYADRLAVVYMLSYGGGVVSGDMFDVVIEIESQAILMLLTQGNTKIFKDRIQQQKWMASLAQTTQPLLGFSTLIPSNLIKAEAEAAATTAAAATAEKEKTFVNPDDVKVSQQHITAAVAPLGTLIILPDPVTSFRDSSFQSKQTFRLEDSSSQLVLLDWFTSGRQTRENWCFRHYMSHIDVWVGKRMVLRDRLVLEDEEYMRKDGSEETSYASRLKPYTCFATLIIISADPTTVSDPLPLKQSIDFLQEKAEQVRMLPNSMHSPEDRSILWSTSPLLGGRGVLVRISGMTTEQVRDFVKNECLGDGLKGIIGEGMFKKVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NIK9</accession>
    <name>A0A162NIK9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_149177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD70014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288054.1">
        <property type="nucleotide sequence ID" value="XM_018432229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NIK9"/>
    <dbReference type="GeneID" id="28993135"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149177"/>
    <dbReference type="InParanoid" id="A0A162NIK9"/>
    <dbReference type="OrthoDB" id="2279924at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD70014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="413" mass="47467" checksum="7955FEE8FE5BA1B0" modified="2016-07-06" version="1">MGTRMTKKKQAAIARASFMYPVLEYDDLSISEFESDSDDTTSNMNHVKKNIQETILPEEIVEGYSDSESVDQLAHKKQPPSGSSVRKREMKDSGIHTSKRPHYNEDIPTETEHVLQELRNVGDEQEVQIEAVSVDLHATSADDISEFSDTNILDDLDDWRPTPSTHQHLSQTRSLMSIQSFDSDVDREEEILEEKERKALVSVRHHIPDLPFDITPTAFRPVYPHPITDRQVRHIKEIKPLTLEASGLANQAREVALDETKDFMKWERSVKATMAHHGSVTWAVFHSKEARLFRMTDTWSENGVIFSWCVPVTDEEQETLKSSTQSQQDDDSVKDIFSQPHVLPSYVPNENDDKYLFGFFFLHSNITSTTEKDFMKETLVGIWPPWTHYTDKLSGSEKKEVFMATRFMANCMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NJ37</accession>
    <name>A0A162NJ37_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_115595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288174.1">
        <property type="nucleotide sequence ID" value="XM_018428470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NJ37"/>
    <dbReference type="STRING" id="763407.A0A162NJ37"/>
    <dbReference type="GeneID" id="28989376"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_115595"/>
    <dbReference type="InParanoid" id="A0A162NJ37"/>
    <dbReference type="OrthoDB" id="27652at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02663">
        <property type="entry name" value="Peptidase_C19G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="6">
        <location>
            <begin position="6"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD70134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="334" mass="38925" checksum="1537BAB9DCF2F7D1" modified="2016-07-06" version="1" fragment="single">EGERYFGLENVSTICFYSNSVVQALYYCKPFREYKDQNNLNLSPGMEDTLFAALKNLFWTISTHKKKTGIVAPVNFINKVKKENELFRSSMHQDAHEFLNYILNTIADDVQKYQRNVAKDAGREKEEKDRQENRRGNILIHSLAENSDHSSNTQSTWVHQLFEGVFSNETKCLMCETVTSRDESFMDLSIDVEINSSVTSCLRQFSASETLCHKNKYFCDVCCGLQEAERRMKIKKLPNILALHLKRFKYQELLQKYIKLTYRVVFPFELRLFNTCDETEDADRMYELWAVVVHIGSGPHHGHYVTLVKSNGRWMLFDDDIVSVITVDAYLRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PJF4</accession>
    <name>A0A162PJF4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PQ-loop-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_168801</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291487.1">
        <property type="nucleotide sequence ID" value="XM_018435941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PJF4"/>
    <dbReference type="FunCoup" id="A0A162PJF4">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="GeneID" id="28996847"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168801"/>
    <dbReference type="InParanoid" id="A0A162PJF4"/>
    <dbReference type="OrthoDB" id="407617at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF37">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD73447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="28607" checksum="BF63D19ED8EF7C36" modified="2016-07-06" version="1">MVNRYVAEQVFSYFGLVLWSFQLAPQVWKSYRRKSTDGVSPWTMLIWAISGALLGNYNVGLNVAIPLQIQPQLFTFIAIICLAQELHYSFKWSVLRSWLAFVITVLLAGGFEAGMVFAFRAAQDNGVDKAITFFGVIPVITILIGFAPQYYTIFRDLKVEGISHVFLAMDFFGSIFSFIALAFRDKMDVLSLVNYAGIAVFDAGILILYYVFKWYNGNEGGRRKKGDISDVETQCPEKETEDKKISPDDSTSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PMF4</accession>
    <name>A0A162PMF4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 9">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHYBLDRAFT_177979</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 9"/>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288356.1">
        <property type="nucleotide sequence ID" value="XM_018437935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PMF4"/>
    <dbReference type="STRING" id="763407.A0A162PMF4"/>
    <dbReference type="GeneID" id="28998841"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_177979"/>
    <dbReference type="InParanoid" id="A0A162PMF4"/>
    <dbReference type="OrthoDB" id="5152799at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000017">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.50:FF:000001">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF3">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD70316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="528" mass="58903" checksum="E1982058BC6BFD73" modified="2016-07-06" version="1">MVLHKHVKSKILPKNRQHTDASKENQSLHSLAYSSRYATTDVPKTEIPQKPAGSTTAYQLIHDELDLDGTPAMNCASFVHTWMEPEADKLMMENISKNMSDQDEYPATMRIHGRCISMIGNMWNAENAIGTATTGSSEAIMLGGLALKKRWQARQKKAGKDTYHPNIIMGNNAQVALEKFARFFDVEARLIPVSDESHYALDIKKAVEACDENTIGIFVILGSTYTGHFEDVKGLSDLLDAYQEKTGIDIPIHVDAASGGFVAPFAFPNLVWDFKIPRVSSINTSGHKYGLCYAGIGWILWKSEEYLPKELIFELHYLGGTEYSYTINFSRPACFMIGQYYNFLRLGVEGFTNVANNDLINAREFAKGLEDSGYFDVVSDLHRPKGVFGWKEKSGISKAKEVVSKAGVIDYNPHLPVVSFKLTDEYKKNCPHVKQGAISTLIRTKGWIVPNYPLPPDADSIEILRVVVRESLSKDMLTLLLEDIVEATKRLANVENAVESFYLTSNIHVGIGKDAEIPSNNNTYSRPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PXQ5</accession>
    <name>A0A162PXQ5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_165441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294987.1">
        <property type="nucleotide sequence ID" value="XM_018435242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PXQ5"/>
    <dbReference type="GeneID" id="28996148"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_165441"/>
    <dbReference type="InParanoid" id="A0A162PXQ5"/>
    <dbReference type="OrthoDB" id="10473177at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="181" mass="21012" checksum="F5346A42BC44EAAA" modified="2016-07-06" version="1">MSLQNTFPSPQDDPFEQAVKAQANDNLNDISSQPHVPRWQHIKTSEEIVDSKNTLRILESKLNSIRSGTRKPLANPANSSLHYESEDESDKDQDQDQDQDYYCSREPELDSQAEAEGVHLLWKSQYVQSEQINRGGSSALPNQEFHEQEQLLWSRAWQKRKSEQEYMPWIDRILGCFNCCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PZ66</accession>
    <name>A0A162PZ66_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_158446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293706.1">
        <property type="nucleotide sequence ID" value="XM_018433789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PZ66"/>
    <dbReference type="GeneID" id="28994695"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_158446"/>
    <dbReference type="InParanoid" id="A0A162PZ66"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="61" mass="7250" checksum="00F97811FDDC0AD7" modified="2016-07-06" version="1">MKAAFTDMRKLFILRVYLIAIIKNLPNVSMAKKPIMYLDKYHCSTDKIWFHNLIFASPLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Q570</accession>
    <name>A0A162Q570_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor TFIID, C-terminal, TATA-box binding transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_106900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298226.1">
        <property type="nucleotide sequence ID" value="XM_018427965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Q570"/>
    <dbReference type="FunCoup" id="A0A162Q570">
        <property type="interactions" value="977"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162Q570"/>
    <dbReference type="GeneID" id="28988871"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_106900"/>
    <dbReference type="InParanoid" id="A0A162Q570"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD80186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="221" mass="24428" checksum="1B090C684D3A513B" modified="2016-07-06" version="1">MATPAVQTPSVPTPQSTPFALPSTPAPLDAPTPRDHNPYAVAGITPTLQNIVATVNLDCRLDLKTIALHARNAEYNPKRFAAVIMRIRDPKTTALIFASGKMVVTGAKSEDDSKLAARKYARIIQKLGFQAKFTDFKIQNIVGSCDIKFPIRLEGLAYSHGHFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKVREEIYQAFQAIYPVLTEFRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T2G4</accession>
    <name>A0A162T2G4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_184094</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441008">
        <property type="protein sequence ID" value="OAD65732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283772.1">
        <property type="nucleotide sequence ID" value="XM_018438881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T2G4"/>
    <dbReference type="FunCoup" id="A0A162T2G4">
        <property type="interactions" value="113"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162T2G4"/>
    <dbReference type="GeneID" id="28999787"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_184094"/>
    <dbReference type="InParanoid" id="A0A162T2G4"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06890">
        <property type="entry name" value="PX_Bem1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11879">
        <property type="entry name" value="SH3_Bem1p_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035550">
        <property type="entry name" value="Bem1/Scd2_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035549">
        <property type="entry name" value="Bem1/Scd2_SH3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF2">
        <property type="entry name" value="SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="37"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="121"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="295"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD65732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="574" mass="63834" checksum="7E4630722B98AF94" modified="2016-07-06" version="1">MNLKEKVKPPRSLRSTRLSVVKNKISTPINFQQSAITPKIVAKALFDYKAQTQREISFHQGDYFHVDKTDNPHWFEAFNPVTHAKGIVPVNYFQILEKNDTPNHLGDPTRTETQLPPVKKMQPLYGVVLYDFQAERFDELDARAGESILVIAQSNVEWFVAKPIGRLGGPGLIPVSFVEIRDALTGHTITSSQPSNPLPRVEEWKRMTMGHDNPEKLHNPSSSALYYAPNTIDTFSRIPTHNSVNTLLGSSNAGSGAGGSASASASAGAIITTAEQIAQEIGNLSIGPRDNSRDNTRSRVVAATVDSYVPEGDQFWFIVFAQMSDRRHRVLYRLYEDFYDFQVTLLQDYPIEAGKTGKPRILPFMPGPQTEVDERLTAKRQTELNIYCQELFQLPRYLVESPLVQDVLFVLHEGDVEIDYDPRTGAPRPESVELSHSILIPEAFGSSTMNTFTPFGRNSNPIKDISQTNTATATATATASTTTTAAKNAIGSSNLIKVKIAYKEEMFAIKVPIDCSFQKLHDRVQERLGGSNVRLRYKDQTQGESLPLETESDIAEAFESSLKIGKLILYATPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T7D1</accession>
    <name>A0A162T7D1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_183804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441001">
        <property type="protein sequence ID" value="OAD66722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284762.1">
        <property type="nucleotide sequence ID" value="XM_018438836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T7D1"/>
    <dbReference type="FunCoup" id="A0A162T7D1">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162T7D1"/>
    <dbReference type="GeneID" id="28999742"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_183804"/>
    <dbReference type="InParanoid" id="A0A162T7D1"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060628">
        <property type="term" value="P:regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007528">
        <property type="entry name" value="RINT1_Tip20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520:SF0">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1 RINT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04437">
        <property type="entry name" value="RINT1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51386">
        <property type="entry name" value="RINT1_TIP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="828" mass="95218" checksum="CBA9A7AFFB7AC28F" modified="2016-07-06" version="1">MDSPQESQFFLGDYIKSPNDLDLNKLKTLLTKRTTEQTQLDQKLNIIRQETQTVLADSRKKAYKEQTSLRELDTALQKTTSDLNEYDVKHNQQKNTDQHLLLNNLKNLENKLRTTEYAKSYIKALLVASELSTKSLNLVKKDPEAAIVPFRQLTKLRAHVKNQIDQEPQDGSYQNLVNQLEKSQHKLWKELNQVLENNFKDSLQSLNWPTPIRPPYGLQLRSKLEGFEKAFHHLLLLQKSLEPEDDKTEPPGEKKVEIPIPIAIMLQDLSLRFRFHFEGSKPTNRLDKPEWYLSHVKTTASSHLPFLVTTVQPIVDSAGLDQTPRISVKDFFIYGLQQDVARKLKKTIPRILNQPSWLSHTVHEVLEFDKSLENEFAYTPPRSSDKRSADVILDNPEWFGAWFAAERQFAQTRYDEIIQDRQAFEAEAEEEGEDIGSNGKSLGSGGGGDPRNIKGTKSSVKILNLIESVTEAYRLVPSLQQRFRFLVEIQLTLLGHYHQRIYSALDSFEALSLIRSVPVPGALPESVTGVMTATETGGTISALKRLYRWWASAYTIGEGIRDWSEDDFFLDMQYQVSQNPKEAQTVMDSLPAHENMFALSLSSNWETPSNSFFAEALNAFDMLSQRIEKLFVKIVAKEWATNAREYAKKDTWWQTSSEQLPGEISSELYVPLQGLRIACQFLYSTLPLSDYLSVYRSICEEIQEWYWRNIITQNQFSKQGSSQLEADMTLGIWKTGKQWVKKPENYTKRLKEATKLLTMTFDGEQDKDALASQAPFNLSYNVFMKYLADPKQQSVLQAELGKLGIEVLSYGQMRDVLRRRNDMLHNWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TDL2</accession>
    <name>A0A162TDL2_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peroxisomal biogenesis factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_175339</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441004">
        <property type="protein sequence ID" value="OAD66283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284323.1">
        <property type="nucleotide sequence ID" value="XM_018437472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TDL2"/>
    <dbReference type="STRING" id="763407.A0A162TDL2"/>
    <dbReference type="GeneID" id="28998378"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175339"/>
    <dbReference type="InParanoid" id="A0A162TDL2"/>
    <dbReference type="OrthoDB" id="411017at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF19">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD66283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27499" checksum="558A7FCC582BC117" modified="2016-07-06" version="1">MATIVKTTQTIQSLHSNPPKLDAPPDIITNRTIAQHVPSRKSVFATVQTILLLFDGRDKALKTIQYTFKVLIHHNVLHSKLWPTMTSKLSLTRRVLRLGTALGPIRILTASLVPPTQNLLLLNTITNNLADDVVCFYKLSLINPVLGKQAQKTAHYCWFISIIADLKSACSALWRLQPISHDQDRSYKNHQDDVWMASVSIVKLVADGVFCACDIWQPSFSGTAQAWSGLISSVLAGYKLWHKSSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TE20</accession>
    <name>A0A162TE20_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_79945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441003">
        <property type="protein sequence ID" value="OAD66393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284433.1">
        <property type="nucleotide sequence ID" value="XM_018443529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TE20"/>
    <dbReference type="GeneID" id="29004434"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_79945"/>
    <dbReference type="InParanoid" id="A0A162TE20"/>
    <dbReference type="OrthoDB" id="2370938at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD66393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="28865" checksum="4975143C6E170F66" modified="2016-07-06" version="1">MINIIQELDIEAISRSQAIVKLLQLDILPHERKFANGLTELVKKLPRVPIEEDVNESELITRFVDPFLCGLFDDPEEGVFIRWTNDITVEARKNETLWTRRPDLTVTSLKGVKWSTSHGYGEVKPVCHEATNFLLSNDLIRVAIFCKNAFDAQNLEGILGLQIIGRSITFYLLVLPSDGLYVMYELGTLQLPNNLCDLCKLLMDIPLGLLVLDVFHRLCIRSVNPFQPSRHRPTVLSLISMASFQLHRIASGLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TFK9</accession>
    <name>A0A162TFK9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_183365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OAD68202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018438759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TFK9"/>
    <dbReference type="STRING" id="763407.A0A162TFK9"/>
    <dbReference type="GeneID" id="28999665"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_183365"/>
    <dbReference type="InParanoid" id="A0A162TFK9"/>
    <dbReference type="OrthoDB" id="5584028at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852:SF1">
        <property type="entry name" value="HIG1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852">
        <property type="entry name" value="YALI0B21208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="24921" checksum="ABB93A27DAF3A84F" modified="2016-07-06" version="1">MNNSSQPPVPSSRPQTIASPPPPPPQPQPQSQPTPSSNYTYSALPPQELPPVTTHEYPGGPLGRAGLETKPRLILLTSVGTLWGFAIGSFLGGQQAGLQYLAENAHRLPTTVQGWYFYHKTKNYRMALGGIKRGAKFAGRTGGLCLMYGAIEAGLDDIRGEADVANSVIAGVTAGTIFSAITRLTRGSFRYSVLFGAAFGLATGGLSDLHRYAIGHPPSYIQWLKQKVSKENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TL78</accession>
    <name>A0A162TL78_PHYB8</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_142748</name>
        <name evidence="2" type="ORF">PHYBLDRAFT_149227</name>
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    <organism evidence="2 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
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            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OAD69442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD75747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287482.1">
        <property type="nucleotide sequence ID" value="XM_018432239.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293787.1">
        <property type="nucleotide sequence ID" value="XM_018430862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TL78"/>
    <dbReference type="GeneID" id="28991768"/>
    <dbReference type="GeneID" id="28993145"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_142748"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149227"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD75747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="110" mass="11850" checksum="E535920C385A3751" modified="2016-07-06" version="1">MNNSQLRTALLSFLPPTALTPLVQPASRLDLSLVALMSTVLATATHIVRTQTRPSQQTYNDVYKPNPRSTLPTGITINNNTSNSKARCNTDVAFDMSPNPESSIGNGGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TPU8</accession>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="763407.A0A162TPU8"/>
    <dbReference type="GeneID" id="28997761"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172700"/>
    <dbReference type="InParanoid" id="A0A162TPU8"/>
    <dbReference type="OrthoDB" id="2276327at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF34">
        <property type="entry name" value="NOTOCHORD-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD68843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1008" mass="114218" checksum="F67243BD7D908AD9" modified="2016-07-06" version="1">MGEYEKLLKRRPAMFDGPSSSASTATATTTATTNLNSNNGPAPMEFIIENPQDTYGHEISDEDEYSDDYILSDSSDDYDETTDDEDTDTRVEYDSQDHIARVAAEMRTFQSLSHAMNAYSNEDSSRQTLYRPNDFADIFTGPTHPFKSKVEFILHALFYGDEDLASERSIKKIMFAMKMVLDVREESGVALDFPTPNAVINYHKQKKNQIPVFPTASFDVVNQDNERHVLWMNKPSDYIKFTMTCPGKSSQISALPDFTENQRLNLNQGEKWKENPLLQHPMITSNGMDYWVGDVVEVQGSPNRYLLEKFFTKDGSILANAFQVYGGHDPRLNHPDDTHFLRFGNSTNFAVSTLKYTIEVDRIMSTVQKDSDLFLGRGFSVSYCPAEIVTYALTGVQSDLWLNKSRVEEFKRRLPGSGLMKVVVCPLNLYPDDTSGNSTKQYNKYDSYLMYFAALPLETRNKRENALFICTSNHTLNAVEMLPPIVDDLVRLEKGIEMYSEDYGEVVLVVAPLLLFMGDNPRQSQLAMHKGTSAKKFCRKCLIPSPRIEQGSIPDAPPYSPVDHHGSEERTRDFLCAFANADSQSELYLNGCELSYIKNGSEEFLRLEAFDPTKDMPVEILHIIPLGLTKYLMTFLWKQKMLTTSEKGRLQEALNSYKSCKSYSRTFRNKLRHTGSFVGRDFKELIQVLPGIMSKLFSDKPSASLFIKALHALGRLSSLVYMRGVDRCLDYYIAQIKHAVTDVTDLLFQLDVQILQKGFSKQDFTFKPKVHLLHHITDDIVRFGSVLQYETENGEQFNKFIREHLFKTNRHSTSRDVATRFGKQFICRHLCNGGSYVVEKPAGNGTRSVRSSIGDFVKLAPVNFPGFNLHFFGSRVNSDNSGLSTPTLCDTLAGVFQSNGQLFLGQVKIVQARDSADRMRKAFFMQKYQIVPNSNVNCIYTPAVVTDNYNNIVVLPLGGLVEVNKDVINIVQAVDIHLSVGSSNNQKFLNVAKFGMFWWMLMNIAKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TQH4</accession>
    <name>A0A162TQH4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_148809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288302.1">
        <property type="nucleotide sequence ID" value="XM_018432163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TQH4"/>
    <dbReference type="STRING" id="763407.A0A162TQH4"/>
    <dbReference type="GeneID" id="28993069"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148809"/>
    <dbReference type="InParanoid" id="A0A162TQH4"/>
    <dbReference type="OrthoDB" id="2257025at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="361" mass="40896" checksum="F13402DFEF216AAA" modified="2016-07-06" version="1">MAANDDLILFTLPRINRPGTDLMRANAVDKYFPQPTEWANATKSDVLYASDNTNSFPPILIEVQYNADDNFLHRLVQYCEEVNKQYSTEPVVLVFVINKIRDSVMSKTTKDRKQKFLLKLPSYPWAKKCLFLNDYSIHDHLNNIPLHPLVALGAFLTAQKVSIIDHDQRDDPIIQQLYGISKHVFEHVATREKTTVDDLLGLCDNTQSKFQKCKEILEDLPNNNLKKRAIDCLNDGLNIIKPYKVKYMSDQSSSSTASSPAASSPALIPAAPSLLLPVLSSLTDPLTSTITQTTTRTPKSSSSENWTFVGNYIRSLGSNKMNWKAYYLKGQRQGYFANYTTPASLKNAYQRRKTNNDEMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TRH5</accession>
    <name>A0A162TRH5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Secreted subtilisin-like serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHYBLDRAFT_79866</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288522.1">
        <property type="nucleotide sequence ID" value="XM_018443516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TRH5"/>
    <dbReference type="STRING" id="763407.A0A162TRH5"/>
    <dbReference type="GeneID" id="29004421"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_79866"/>
    <dbReference type="InParanoid" id="A0A162TRH5"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07489">
        <property type="entry name" value="Peptidases_S8_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="C5a/SBT2-like_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034187">
        <property type="entry name" value="Peptidases_S8_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 9 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007839925" evidence="11">
        <location>
            <begin position="30"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="12">
        <location>
            <begin position="161"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="13">
        <location>
            <begin position="387"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="C5a peptidase/Subtilisin-like protease SBT2-like Fn3-like" evidence="14">
        <location>
            <begin position="607"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAD70482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="875" mass="92909" checksum="20A3EFA5B120743F" modified="2016-07-06" version="1">MKRRSFSVLPLFTAGVCLAVLILIAPSEAVSHSKYKPSTKEVIPNRYVVEFNYGDSQSATTFVNSVKSKYKKAKVHVAEQFEHKIFSGISFGLEGLDEEDHNAALKSVLDQNTVKAVYPVNLIKRPDVTFKSVPASTKAPSILPHAMTQVDRVHSELKKFGKGVKVGVVDTGVDYLHPALGGGFGEGFKVQYGYDLVGNAYTGYNTPVPDSDPIDSCTAESGASGHGTHVSGIIAGYDAQTNFTGVAPQATLGMWRVFGCTGSTGGDVLVKAFLMAYDAGMDVISVSIGEASAWTDGPDTIVAQRIAEDGIPFIVSASNSGADGAFTVGMPSTAKDVWSVASVDNNYYLVDLFKASTIADKIPYLTSSSSKIPDGTIAAGDKNVGSGSDACSTATIPDLTGKIAIVQRGSCTFDDKATNVAKAGAIGLIVYNSANGDSFTPSNPTSPIPVAGISTADGLALLDAIKAGTTTLKFDTAQSLYPLISGNTVSDFSSVGASYELDLKPNVAGIGGQVFSTLPRFLGSWGMMSGTSMAAPYVSGSVALFIEARGLKKKNQVISEQFKNYALQLANTQVKTSTENPLLQGAGLVQVYDAISAKVRISPTQLSFNDTSSTKYKTQTLSIYNSGKVRTTFKIINEPSIAVAPYDRAAQGYAPLAPTGFSSAKAKLVFSKTSITLNAGEKKTIRVTVVPPNTDPKDHIMYGGFIHFKSGNQKAAIDATVPYFGVVGKQIELPIFDAETPYLSDPTGGPVYLKNETYTYDRTKSSTAPTIVYRLLTPTAKFDVDVLNAKTKKSIGKTFTDYVYLSRNTFEADNYISGAVWDATYVPTGFSDISSGIPVPSGNYILNLRALKLFGNPKNSKDWETFQTGTIVVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TTU4</accession>
    <name>A0A162TTU4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CST complex subunit STN1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Suppressor of cdc thirteen homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_148953</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287803.1">
        <property type="nucleotide sequence ID" value="XM_018432187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TTU4"/>
    <dbReference type="STRING" id="763407.A0A162TTU4"/>
    <dbReference type="GeneID" id="28993093"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_148953"/>
    <dbReference type="InParanoid" id="A0A162TTU4"/>
    <dbReference type="OrthoDB" id="77828at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF33">
        <property type="entry name" value="CST COMPLEX SUBUNIT STN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0779">Telomere</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD69763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="314" mass="36531" checksum="61F563EE0DD823C5" modified="2016-07-06" version="1">MELTLKDITYLNQDPLFNTPLKLLIRNVIDISPHKEFKDLYQHYDHIVRYAEVCGVIVGIEQNYYGHTYTVDDSTGLLDCHYWKLMDSEPLAFNLSQTVRLRGKLSDYREKRQLIIDDKELVENMEESVHWVEALHLDKYYRKSYMLPSLPESSDIQSEEDPFESALLAYWRKHPDDVYSFAEVCQDPDLVELAHKLLSEVSGWGVTEHDLVELFSSTTKALARAGYLAPAGSSESNLYRLMTPKELEKGVLKIINEICELMDLGIRKNYIIERFRKYPAFCFVEDSTIISIIKSLLEQSVLYESDYNVYKIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TW23</accession>
    <name>A0A162TW23_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_70781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289472.1">
        <property type="nucleotide sequence ID" value="XM_018442335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TW23"/>
    <dbReference type="GeneID" id="29003241"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70781"/>
    <dbReference type="InParanoid" id="A0A162TW23"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="137" mass="15971" checksum="083F2611B72F6662" modified="2016-07-06" version="1">MIPEFYYLYCGGYLRSLLIDVALNADNLSVAHCEFFENFLVQQGDPTFIIGWPPMEIAHKPTFENTRIEDGSDWAYALVNWSDESRLTVNGIDERARATRRVDEIYRDFSFQKDNGVAVMLALIRSDERIAHEFQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U3I7</accession>
    <name>A0A162U3I7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_147064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290123.1">
        <property type="nucleotide sequence ID" value="XM_018431791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U3I7"/>
    <dbReference type="GeneID" id="28992697"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_147064"/>
    <dbReference type="InParanoid" id="A0A162U3I7"/>
    <dbReference type="OrthoDB" id="2290289at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="247" mass="28565" checksum="3E187D716161B6BC" modified="2016-07-06" version="1">MKHKHEDNSSENSAKRKELSQKLKKKLPWPSSIEKTDALKEITTNINTLWSLYQPIDSEPDTFNQPLIFGKNLQNIQPHKMTVSNFVNTVKTRIKDDTFCPVKYTDKRGYRFFSLLPVYLFQGKSVQIDAHAFWRLLFGFSKIGFRARKSLSNGRKTLRALYILMAIQYHFCSHESQRKATLMPLPKKKPPDFRNEIENGCQVWALDPGITAVLQCNESVFKVIWNCDVMAAKNNGARLSPFLRPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U9K0</accession>
    <name>A0A162U9K0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_145015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292622.1">
        <property type="nucleotide sequence ID" value="XM_018431347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U9K0"/>
    <dbReference type="GeneID" id="28992253"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_145015"/>
    <dbReference type="InParanoid" id="A0A162U9K0"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="225" mass="25839" checksum="C4DC6CCE1FF9F8CA" modified="2016-07-06" version="1">MNVNSFLNDAANLPTNAVEKLQLKLQCRKEFKISFAKEFNLQQKVVENMAEAKIKNKRKLDGENYRRKEIIDSYNSMGPLEKGRYYEMAKEDSTTLHQESSVPDVNHDAKSILTIMETMKLSMNYDSLFLFWESGTSSSRKIGCLLSGDTSSIFFKCIEEDGALKSFLEAMGNVERRPMQEIQPMTIAVNDFRNKMNKRLISLFNAIKNKKGTIRAIGWPEKRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UAK8</accession>
    <name>A0A162UAK8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription activator GCR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_61139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292852.1">
        <property type="nucleotide sequence ID" value="XM_018440757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UAK8"/>
    <dbReference type="STRING" id="763407.A0A162UAK8"/>
    <dbReference type="GeneID" id="29001663"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61139"/>
    <dbReference type="InParanoid" id="A0A162UAK8"/>
    <dbReference type="OrthoDB" id="2289316at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060963">
        <property type="term" value="P:positive regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052146">
        <property type="entry name" value="HOT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022210">
        <property type="entry name" value="TF_GCR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37784:SF2">
        <property type="entry name" value="HIGH-OSMOLARITY-INDUCED TRANSCRIPTION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37784">
        <property type="entry name" value="PROTEIN MSN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12550">
        <property type="entry name" value="GCR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription activator GCR1-like" evidence="2">
        <location>
            <begin position="270"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD74812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="334" mass="38148" checksum="4AA62BBCD9B1BE86" modified="2016-07-06" version="1">MMEAQVSTSRKAEVNRPENTKRSYAPKQKEYKDWCDEAFSSISLKNCYTVYGDKLHLFLKDCVVNRTHRRDTGKTIKYGTAMAYLAAIVDMYQKQVKVAVGQHEVHNERAHRAENQDRGLGTLVDGYTTENEIASIVSYYFLRSSGGHPLWQHGVFHDPKYIEFKRSVKAFVETDVEPTDILLQRALPLMARKLADMQNADSGFRREVLREFGVLHQKIDDLVSGRIPLWSLQEDGGERGEARSTEVQAFPVPANNSGPISQLSDIPVRYRMSRDVQTVPDLWREWHVGLSGCVSIHEMETRRKRIVNRIKKYMVDNSSLVGSLSESVTPLKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UCW0</accession>
    <name>A0A162UCW0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="11">G protein alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Gpa1B</name>
        <name evidence="11" type="ORF">PHYBLDRAFT_74741</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293342.1">
        <property type="nucleotide sequence ID" value="XM_018443032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UCW0"/>
    <dbReference type="STRING" id="763407.A0A162UCW0"/>
    <dbReference type="GeneID" id="29003938"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_74741"/>
    <dbReference type="InParanoid" id="A0A162UCW0"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002307">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="148"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="173"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="198"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAD75302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="350" mass="40486" checksum="CD3BA05328327D2B" modified="2016-07-06" version="1">MGCCHSNDSQDGKARNEEIESQLKRDKHNLQNEVKMLLLGAGESGKSTILKQMKLIHDCGYSKEERIAFKEIIFSNAMQSMKVIIDAMEDMELPLTHLRQYADIIMNLPAQIERDTLPLEVTQAVKILWKDPNLQAAFERSREFQLNDSAKYYFDSIDRIGDPHYVPTDQDVLRSRVKTTGITETTFVIENLTYRMFDVGGQRSERKKWIHCFENVTALIFLVAISEYDQFLIEDETVNRMQEALTLFDSICNSRWFSKTSIILFLNKIDIFKQKLPKHPLYESFANFTGPETYEAAGEYILKRFLSLNTEEKQIYTHFTCATDTDQIKFVMGAVNDIIIQNNLQDVGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UFL1</accession>
    <name>A0A162UFL1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_167119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292813.1">
        <property type="nucleotide sequence ID" value="XM_018435566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UFL1"/>
    <dbReference type="GeneID" id="28996472"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167119"/>
    <dbReference type="InParanoid" id="A0A162UFL1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="214" mass="25019" checksum="A7CD94F5F09C9630" modified="2016-07-06" version="1">MKSQECTPRLEKVQRFKIVSYNQIRRYRISLSNLSRTTNIKRNSLEFLGYDSLQKISRYRKQGISLQKISYLDLVVLLIRNLKSIKNKGDYSWARASSASIALVCYKTDIGIEWSNYWRDGGAKEVRLLKLDGARKQTIKCLSQHYVLESASPERMLIGFFLESCTRVHPELLEDRDSWKCPEETDRLYAANEDLMAYYWSELSSSSILNTYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ULA7</accession>
    <name>A0A162ULA7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_74346</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294153.1">
        <property type="nucleotide sequence ID" value="XM_018443012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ULA7"/>
    <dbReference type="STRING" id="763407.A0A162ULA7"/>
    <dbReference type="GeneID" id="29003918"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_74346"/>
    <dbReference type="InParanoid" id="A0A162ULA7"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF30">
        <property type="entry name" value="DELTA 8-(E)-SPHINGOLIPID DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="13">
        <location>
            <begin position="15"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD76113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="507" mass="59088" checksum="43E89CBD142B2FB6" modified="2016-07-06" version="1">MPPNAEPRNERLDNLKYITAQELQDRIKQGDALFIYDAKVYKVNRFMANHPGGDLAIRHSLGRDVTDEIRSLHPPAVYERMIHHFYAGEYVPDLEVSKKAVKETMTTSWEGGISVRAFDDEIQQLHDHHAEDLSKDQISQKNLDMLTIRKHFRHLEQEIKDRGLFECNYWKYGKEVCRYLLFLYISLWFTLTGSETWHYMVGACFMAFFWHQLVFTAHDAGHNEITGRLEIDHLIGVLIANFIGGLSLGWWKDSHNVHHIVTNHPEHDPDIQHMPFMAITTKLFNNLYSTYYGRVMKFDAPSRFFIKYQHYLYYLILSFGRFNLHVLSFTYLFSSKNVRNRKLELTGIAFFFVWYGALLSTLPSWGVVFAYIMVSYMLTFPLHVQITLSHFGMSTYDGGPNESFAAKMLRTTMDVDCPEWLDWFHGGLQYQAVHHLFPRIPRHNLRLCVPLVKEFCKETGLHYYMYNFSTGNGVILGALKSVADQVVLMNDVAKYNAGVWNSEKSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UMX9</accession>
    <name>A0A162UMX9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_166411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294483.1">
        <property type="nucleotide sequence ID" value="XM_018435413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UMX9"/>
    <dbReference type="GeneID" id="28996319"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166411"/>
    <dbReference type="InParanoid" id="A0A162UMX9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD76443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="139" mass="16370" checksum="251083DD637FF72C" modified="2016-07-06" version="1">MVLNPQKTNKRKEIGHYRGFKGVSNRDDRYTKDRIMKYVHYSVQAQTVDLQGCFILFASIVYFSDLIWFPKYTEFSYMYKSKAYLHQKFSCNGLKKSKVLCTLEFNAMQCNAMQYCFPRNPEENIKFKAIKAPSVLIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V131</accession>
    <name>A0A162V131_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_179059</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297322.1">
        <property type="nucleotide sequence ID" value="XM_018438095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V131"/>
    <dbReference type="FunCoup" id="A0A162V131">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162V131"/>
    <dbReference type="GeneID" id="28999001"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_179059"/>
    <dbReference type="InParanoid" id="A0A162V131"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF16">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD79282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="313" mass="33896" checksum="B848AC7F85F0504C" modified="2016-07-06" version="1">MTLGFDDELPEDVYVFDAIRKNLTYEKTGVASVLKPAPVAQHLPAFDSKGKPCFKPYVGSGKLEGKYALITGADSGIGRSIATLYALEGVAGITIVYRDEEEDADAMYTKNTIEAQSKCKIHLIARDIGYEKNCQEILDAHLATFGRIDILVNNAAEQHKVLRVEDLVADTVERTFRTNVFGPIFMTKLVCNHLVAGGVVINTASIAAYRGMDVLVDYSATKGAVVSFTRALSQQLAPRRIRVNAVAPGPVWTPLIPNTFSQEEIQNFGSFPPFKRPAQPAEVAAAFVFLASDCASFITGQVIHPNGGTVINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V693</accession>
    <name>A0A162V693_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_160940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298333.1">
        <property type="nucleotide sequence ID" value="XM_018434319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V693"/>
    <dbReference type="GeneID" id="28995225"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160940"/>
    <dbReference type="InParanoid" id="A0A162V693"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="323" mass="36198" checksum="4EE7933B396ECBAD" modified="2016-07-06" version="1">MTNTRRECTIALRPVEITNQQLMEILSTVRADMSTVKGQIGNVEQTLTNVNGRIGVLATTSTNTISAIDSLARTPLAAPVRAKLTVAAPVVISNHESTREESNAVYAHIHNLMWKPKLSLRTPENILASNLKPRWDTNVAFNKSPNREIAERLLSNLERRFGSSSMRRSDLRKRLHTNFTSRTRRERMSDDEIVETNALTRRAARADDNECHCVLAYKDNKEAIDLVMLRDCANTLQKAVMSDGESADEMDEDGIKHVIHIVQPGWRSDECNRFIALVDTYAVQAMGSSANQRICRITTSVSNSAVPDNISPNFPWWALRDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V7M7</accession>
    <name>A0A162V7M7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nucleoporin Nup188 N-terminal subdomain III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_61695</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298683.1">
        <property type="nucleotide sequence ID" value="XM_018440845.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A162V7M7">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162V7M7"/>
    <dbReference type="GeneID" id="29001751"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61695"/>
    <dbReference type="InParanoid" id="A0A162V7M7"/>
    <dbReference type="OrthoDB" id="102511at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044840">
        <property type="entry name" value="Nup188"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048883">
        <property type="entry name" value="Nup188_N-subdom_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431">
        <property type="entry name" value="NUCLEOPORIN NUP188 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21093">
        <property type="entry name" value="Nup188_N-subdom_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal subdomain III" evidence="8">
        <location>
            <begin position="558"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD80643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1799" mass="204084" checksum="4B080FF920C25E9A" modified="2016-07-06" version="1">MAQLTQKTTGPFQTLFDAIERSDGLYFQQGSANASDDSLQTLLAERANDLSLGLDHFTPPSDASQSKLTNSTTSIIVDKKTIKIDAAAKDVINELSHDLQLNQLQAAVIWDACTSVDKDAQCDLISQATNFYYQERLAILKVVSSMLRISHDDEHPWTFTAREAIDNLLEKGYVERILTQLEQLMKKTAPEMTVKNLKQWALQNVHEQKALLDILYLVHLNRSCEPQLLVHMIELCQSTMFGMRLDFDYAFEEEGKSLQKQVYGKLILTAVQLLDLNTPLDALSGLHNKHIQQKFLATCPDIIIEINDKVSAMKNIPLASVFLLGWSCFLHKLNMWIDKERPDTDYTPVKNIIKQDDNHSLDTTLATKSLELDALNYISSLLESYLLEEDPNQNGYRATIRTILDGLTEIIRPYALPSKHYDCLVDATCKLYKGQTELCEMFWEAEEHADAHSLLNTATCRFPFISTPLLRLLSSLTGSREDEDQSNSLAQNVFDKLLELTTLTSYVVDNVMLGEDNRGIYPLAPIQIAKTHGPVAGIQIDADNEGILLSDQKLNRIIAWKKTYSGWHLMLNTLFGFAEYPQATTDSIDPVLELMQTILSHDNILKQMIKHAEDIVTPNSQSTRRQPLLVAVFTDLLDVCTAMDNPSPPTLTRIVRCMTSLLPYYRQLVWKNIGASPSLTVKDSLNYLILDVRPSIQQIIRSIECKSGRYSLLLSVLDLIVALINDTQADWWETENVDISRKEKAGILKSYISYLLFDILPNHGTWRYFSLSERFQIGSKIYWILIYTTMYFKSLDKDLNELRKTVYSYFLYDANPFYLAPLLECLTEGPGVATKLLESQQYTAGDEAEQMVESGLIFTRLLLTYRLEDIARHPKGSVLEQLLLERTGNTKTKTLLQIAQAISYTYSDRIPTEAITILRLLAQTTSGWTPVPMFAEQLGDRDQIYAILCSFLEVAENSSRDPELLVAIWQMLTVLLKTQPSLAILFLDCGDSVMPSPKSAVKQQKTVESGSAVKAAVDLFQNWQMWATDAPAVLSSVLRFLATFWETAFDHYSLVQRTRSDNALWLGISEILLNPNEPVMTNEDLSWEDDKTSHHDDTQRACCSSLDKAFALQILTFEIHLTAHADNRNNMTLAERLPAGVKTLLVKMSEPSKLAWMRDTFIRNNFDPSLASTAHESSQNLVSLLDSTHAEALLSQRQRLSSDPLEDTYYGDDFLYDIELAYRRLTLMKDHLSSRYNITPDIVVTPKVLAILHVQKTADQVLGDLCRANHNYSKVDSDMILLEAFKNFIDTASYQVPGLIWANKLETSLFDFIMNALTRMGNLINRDDSISNKTANIIASLVRDTIEDWTRQNSTTPVYVQKTLELVSEMCALVNKPFKDTTRHLLLETILIALRSVRNRDLTRQPPRINDSLSLLLGVVCPLFASTSQLALYESEKSEELKDEAIKQSTVLTFLLRELVRPANLVYNIWLPILERHSTLPSLLKFIKQAIALVVLEIKCKSKETDYSLQISPCADNLLSLLTALSMQPQATRLLIQHEIFTLLNDNSLSLQLRDGTLETFIECGTQKEYNPLHHLWCHMLRVMANILHACPINSVIQQTLIFLERYGARLEIAFFTANGVSDITADSLSEPIMIEIELLCTLIQYLSKYLEMSLANGQDIFSAFNNAAFPLLRVYLDLFTHPKQLERTLPKCASKKATQVRMARISRTILLSMAMLFKEEEFRTDSSSKWPIYKSTKPPTIEGLINSMIVGINYIDQWKSQKDKEVWNKEGQITSISVVFAELFRVVQRYHKLLSLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V8W1</accession>
    <name>A0A162V8W1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_61987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298983.1">
        <property type="nucleotide sequence ID" value="XM_018440885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V8W1"/>
    <dbReference type="GeneID" id="29001791"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_61987"/>
    <dbReference type="InParanoid" id="A0A162V8W1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="180" mass="20932" checksum="2199D0A1C7C076B1" modified="2016-07-06" version="1">MLIKKKDNKLIDSETDKKSFERARGIRIHRNEYDHTLDIHDKLNKDILIKTQQNTIKRCQLKKFYKCYISSYIKGLKIDCIYGIIYGIKIKCLIIRTRPRTAHFSVVFDVWLLLYLGVSIYLGSLQHQNQNLNQVENSLLQTSLTYITLFAIPGLLISSDIYNQPSLSVIPIIPNPLSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162VB11</accession>
    <name>A0A162VB11_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_105125</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299433.1">
        <property type="nucleotide sequence ID" value="XM_018427886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162VB11"/>
    <dbReference type="STRING" id="763407.A0A162VB11"/>
    <dbReference type="GeneID" id="28988792"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_105125"/>
    <dbReference type="InParanoid" id="A0A162VB11"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000013">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000007">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050743">
        <property type="entry name" value="2-oxoacid_DH_E2_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF5">
        <property type="entry name" value="LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="11">
        <location>
            <begin position="43"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="12">
        <location>
            <begin position="164"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD81393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="461" mass="51378" checksum="BE5DB312BDCAD3E0" modified="2016-07-06" version="1">MFIYIHCVFRIQDLTWTTHQEKYVYKPWITRRSFHSSILSRAKQPFLLADIGEGIREVEIIQWFVQPGSVVEEFDRICEVQSDKAAVEITSRYAGMISKLHYQLNGVATVGAPLVDIETADEYVDGQNTPVAENVKVPESIPNTKPVETPLVENRSRDPGVLSLATPAVRRLLFENNLEVTEIKGTGKNQRVLKEDIIRFLTEKKDTTGNPSQPVLSVDPNNQGTPLTDTQKVMFLAMTHSLAIPQLGYKDEVDLTLTNTYRQALNKSISDHPGRHPFTKISHLPILLKSLSLALTQFPIMNASITTSDQGRLNQVVYKTSHNIGLAMDTPQGLKVPNIKDVQDKNLFEIASELHRLVSLGKKNELSASDLTGATITLSNSGTFGGTYANPMVFPSELAIVALGKIQTLPRLENGKIVAKQVMPISWAADHRLIDGATMARFSNQWKHWVENPAIFTSMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162W7Z8</accession>
    <name>A0A162W7Z8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_176288</name>
        <name evidence="1" type="ORF">PHYBLDRAFT_72585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441011">
        <property type="protein sequence ID" value="OAD65233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV441011">
        <property type="protein sequence ID" value="OAD65235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283273.1">
        <property type="nucleotide sequence ID" value="XM_018442678.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283275.1">
        <property type="nucleotide sequence ID" value="XM_018437722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162W7Z8"/>
    <dbReference type="GeneID" id="28998628"/>
    <dbReference type="GeneID" id="29003584"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176288"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_72585"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="154" mass="17039" checksum="61095B5C64785DAB" modified="2016-07-06" version="1">MVTLQSLLQYHGLLNSISFKASVSKLIHCPSSHKLSTFALANMSGKVVFRSIASLTFSAAIHRSFSFVDAHMSIKIVFLGRFGLKVLEFGSGSPLLVYFKLFMIFKLYSLIKDTNSLENHQNLSFNIVSDIPYLDSYGDDAGESCSRGGIDESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WXU4</accession>
    <name>A0A162WXU4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_147932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289475.1">
        <property type="nucleotide sequence ID" value="XM_018431976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WXU4"/>
    <dbReference type="STRING" id="763407.A0A162WXU4"/>
    <dbReference type="GeneID" id="28992882"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_147932"/>
    <dbReference type="InParanoid" id="A0A162WXU4"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="139"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD71435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="750" mass="86415" checksum="E201AB7F1AEBBCE6" modified="2016-07-06" version="1">MGKFPDLTFPSSLPNDPNQTDAEAIKKTQPQKIVKRAGVYLHRKLGLFCSKPPQHSIKKMCSNVSSGRISVYTLPTSIEDEVAARKEFLRRPTDDTHESLYKGFKPNGFGTPCSYKTWKESINPKQYQQLSRLSPKQQKYQELIHEVILTECKYIEDLELVQKIFIKDAVEWEGLPSTLLKIFNSTNKIVELHKSILKDFLCRQAKEHPEIRTIGDIFDGYVDSMEIYSTYFVNFEQANHVITNALKSKSDLLGTYIRNRASWSECRNLPLQSFMLLPIQRIMKYPLFFRQLRECLEPEDSIFWEMQQLETKMDKAIRLIENDKAEAERYHRLEDLTTRISGLDPGRRLIHEGPLDLLPCSQNPLTDSSNDIYGSSISFNPCGSVQSLYVHRPYLQRQSSAQSITSPHPNVLKRRNSTFSIKEKKKHLYVFLFDDLIICTKIRSTSREIDENIIAKVESYHGPNPEALFRVVQEPGQLTLVDRTVTRKVARQDKTGRLLGSLRKPTAAAFNAMYNSTTEYEEHPLQFMCSIASKRIVVYHFEAPTAHDKDVWCTRLQEASKLHVRSPDTVQHDPTKDTTELKGGCSILGASINYTDRHTENNNTQHYLSDEQDELKDVVVQAQYSPENNDESSDDYTATSYSEDQPRNEDTAEQTLASALREASQELSRISLESTSKTEHMDFVMDFAVDLDDNMGPKFKVSDFDKYVFNHSHERFSVPIILEEKDEPMEVKYYTLKSPRVGRFPQTFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162X445</accession>
    <name>A0A162X445_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_187380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290465.1">
        <property type="nucleotide sequence ID" value="XM_018439375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162X445"/>
    <dbReference type="GeneID" id="29000281"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_187380"/>
    <dbReference type="InParanoid" id="A0A162X445"/>
    <dbReference type="OrthoDB" id="2260752at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="384" mass="44892" checksum="762A7A58BDF2F110" modified="2016-07-06" version="1">MNLTNSYEYDFSIGTDYMSTLGIGIYGLPLSYDDTDSSKERREADRRFNNKSDLLESIERENEQKENNPAVDPKQFEDAMDYICPFIKDNQDIPKGSFCTIPESVVCLDTPENATAFRSPYPIPYKMQGVVDEQQRIGEAPESIKDINKANKRLLKDMKVVNSIPKEKSGIKRKNYAKTALQKKKRIKQLSLQEQMNNLFILLMIQQKAVLMLCRDVGKMNYVYCRRGMLLTWGTMISNEYNVDEYINKRKGRSIYSGKYPRLSRGRPGFNSRSESVLMLSFLIWVGFPFTITKSKSKSKGQTHWGSESIFKKYILLWWLKLKKFLRGRIEDLRLGTKIHKNLCRFCLLRKDFVSKFDKVSTLNYYCYLYYFGLGKLYDWGQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XYC5</accession>
    <name>A0A162XYC5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHYBLDRAFT_76314</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295305.1">
        <property type="nucleotide sequence ID" value="XM_018443139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XYC5"/>
    <dbReference type="SMR" id="A0A162XYC5"/>
    <dbReference type="STRING" id="763407.A0A162XYC5"/>
    <dbReference type="GeneID" id="29004045"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_76314"/>
    <dbReference type="InParanoid" id="A0A162XYC5"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000064">
        <property type="entry name" value="Vivid PAS protein VVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF7">
        <property type="entry name" value="GATA-FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0157">Chromophore</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="15">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="15">
        <location>
            <begin position="341"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="15">
        <location>
            <begin position="491"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAD77265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="737" mass="82183" checksum="F26F3E4A3898FA3B" modified="2016-07-06" version="1">MNPFENIVPFNPQLYESGNVPPSTDRLFSYSGYTAGLITGMHQNVGPSAPPPPQPPQPMFHGMPPRQNMPVSVPVPVPIPGPISLPEATGPTNPNEVGARYSSMYASTGFDMLSILARVANRPNPQINLGPVDLSCSFVVVDAHQYDAPIVYASPTFEKLTGYTPSEVVGRNCRFLQAPDGRVALGSRRKYTDNTAVCHIKTHISQGKESQASLINYRKTGQPFVNLLTVIPVAWESDEIDYFVGLQVDLVEQPNLIFDSMKDGTYMVNYRSLVIPQSLQPNNPMNQIENPSEVVQEWVRPPSPKPVAPTIPNEALMDVETLIKEASTDEGKSRRCWHELLLDQSPDFIHVLTVKGIFLYCSEATRPLLEYDPNELVGKSLKEICHPSDITTVMRELKQSSSDASEPVNLIYRVKRKNSGYMWIECYGKLRNEDGRGRKYVVLSGRERPVYQFPRNFLSLKKRVQPFDQQQQQNSGAMSSGTDDHEFWGKLSLDGLLLYASWTCANILGLPPSQVIGTSLYQLMRSNRTTDLTRALAEVKEGKIVYLRHALVNNTGDEIMVVSSFYPDGMSSLQDQPSFVLMQTKVIFDDMVPVDEPAFISTDPDVKKKGRADAVPVLGDNADSTTTTTTATTTTTTTIAAARAQRQPFMCVGEKVIEELDIQRDANWQYELHQLRINNKKLRDELGLLLTKAKKKSVEPMDKICSTCLRRLPGSTELLGNNLDTPVFCNTCTMRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Y145</accession>
    <name>A0A162Y145_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_164693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295845.1">
        <property type="nucleotide sequence ID" value="XM_018435060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Y145"/>
    <dbReference type="GeneID" id="28995966"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164693"/>
    <dbReference type="InParanoid" id="A0A162Y145"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="129" mass="14972" checksum="50B7B9ACAD118FB7" modified="2016-07-06" version="1">MQEPIEAFFYGKVYDKQYHIRRSWGGGDNNNCVTKNKQWRHFQRLDNGQECSNFLPMTRSPYHLPQKNMRDNTSQKDVKTNITFSVVGELSATFPFLVINAMNDNVSEAKTEYAVVDFLASLLFSDYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162YDU1</accession>
    <name>A0A162YDU1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP synthase F0 subcomplex subunit F ATP17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ATP17_2</name>
        <name evidence="2" type="ORF">PHYBLDRAFT_130456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298165.1">
        <property type="nucleotide sequence ID" value="XM_018429364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162YDU1"/>
    <dbReference type="FunCoup" id="A0A162YDU1">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162YDU1"/>
    <dbReference type="GeneID" id="28990270"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_130456"/>
    <dbReference type="InParanoid" id="A0A162YDU1"/>
    <dbReference type="OrthoDB" id="5561579at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019727">
        <property type="entry name" value="ATP_synth_F0_fsu_mt_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10791">
        <property type="entry name" value="F1F0-ATPsyn_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD80125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="105" mass="11740" checksum="57A6C307E936E3D8" modified="2016-07-06" version="1">MNAIFRRAYTTKSLIPPNLAASTKTTGAGQDAQISQLVNFYKKLPKGAAQVAKPSGPWGHYKARYIDGDNASMTPMFHALFGIFVIGYSIDYHFHLKHHKNVEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162Z9N5</accession>
    <name>A0A162Z9N5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_72572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441011">
        <property type="protein sequence ID" value="OAD65251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283291.1">
        <property type="nucleotide sequence ID" value="XM_018442675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162Z9N5"/>
    <dbReference type="GeneID" id="29003581"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_72572"/>
    <dbReference type="InParanoid" id="A0A162Z9N5"/>
    <dbReference type="OrthoDB" id="2243238at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="611" mass="73038" checksum="C4E1C43064635142" modified="2016-07-06" version="1">MVTMLPPNILAYLATHVYKYDWRNCALVCKQWTEPFLNAYWAQVYFGGYMLNKLFDKFGLKEVYQWNAHRTWALNIRLFTKDLKYILVLQQTYSRIKYLIYLIYDEDIFAVKTDWSLWKTLSHLELDFRKVELTIDEFLEQLSPLTCLVHLTICQYNDNINRPDTSLTDMESIHSYFPHLQYININTLFKPISEKEIETIRNVEPAHTVTKIVLYFPYIDPSWIFYFAHKYPNLVTCNLRSHELKPRFYLPPYDQKKYQIQPQLLLSSKQFFPCLQTANIIVHDNNYWLFYLFYDTLQRCNVKIKHATIKFNENMSKENGLNSWIKYLSESVISLNIYSSCCNQSIPVETNPVVLYKNLTVLKILVCPRVDMEIILNYCPVLQSLYITNSMIHSPEYPLSMHVPHPLQRLEIEMAQTSVSVFKYISFRCRQLKYMKLKNIFYKPSDMNETGQILVDMSFSQLKVLKTSESEIDDPEDIYGIISPFFLHIVIEQIGNVGTDQVQAPRSNWYHLCVDKTNRKSRLLAWELGRRDIEFCQRYLKDFKRRKGREKKRKDMKRSSYNYKLKRFWKRDLQHGVLIFRLKSVETYFLYEKNADNLILYSKPESEPEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZK64</accession>
    <name>A0A162ZK64_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4112 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_63640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285401.1">
        <property type="nucleotide sequence ID" value="XM_018441151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZK64"/>
    <dbReference type="STRING" id="763407.A0A162ZK64"/>
    <dbReference type="GeneID" id="29002057"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63640"/>
    <dbReference type="InParanoid" id="A0A162ZK64"/>
    <dbReference type="OrthoDB" id="2103474at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="MEMBRANE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519:SF2">
        <property type="entry name" value="PH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD67361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="25636" checksum="2C352C3C373420A8" modified="2016-07-06" version="1">MGLNKESLAKYAVKHALEPFNVLNEAHATKEIPKPVQQEQQSRKWWTSRVPKPESILSTKEQNILKKVKSRAYFLDRGISCCCIQIGFDGLVGFVPVIGDFIGLVLAFQLVEMCMRAGLPKSILSQMMFNIGIDFAIGLVPIVGDILDIFYKCNTRNAILLERYLLQRRQEELASGPSSSSKTPLLNSSESAPIIMETIHTPGSFQPHHNNHHYFTGIVIDIMLVNILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZNP8</accession>
    <name>A0A162ZNP8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_173574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440996">
        <property type="protein sequence ID" value="OAD68081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286121.1">
        <property type="nucleotide sequence ID" value="XM_018437060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZNP8"/>
    <dbReference type="GeneID" id="28997966"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_173574"/>
    <dbReference type="InParanoid" id="A0A162ZNP8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="178" mass="21004" checksum="CF9FA3AEC1EA92F4" modified="2016-07-06" version="1">MTSTKSCQMRLRQKVHRTGQVMTWSILMSEKPILIVECFLAISYVWLNRTIKKKCGECECECEYDAMRRSYLILRQQQQERRFRGRFHRSRDQENSVTKYKVTIQADDAGISILKQTPDITQVPTYRSCHHRLRRDLLPLLFLTKTPRAKSGSFTPLATLEEGIRLENLRINDIRILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ZRM8</accession>
    <name>A0A162ZRM8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-aminobutyrate aminotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_127459</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286661.1">
        <property type="nucleotide sequence ID" value="XM_018429164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ZRM8"/>
    <dbReference type="STRING" id="763407.A0A162ZRM8"/>
    <dbReference type="GeneID" id="28990070"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_127459"/>
    <dbReference type="InParanoid" id="A0A162ZRM8"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000013">
        <property type="entry name" value="4-aminobutyrate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF58">
        <property type="entry name" value="LEUCINE_METHIONINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD68621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="47366" checksum="4BD00BC9E98042B9" modified="2016-07-06" version="1">MSIAAKLAQFGKQHIARGIGRSTELVISKGKGTYVWCVEGKKYLDLTTGIGVTNTGHCHPTVVKAVQEQAANLSHGQVNIFFQKPMLDLIEGLKNRMPSPKLDTFFFWNSGSEAVEAAIKLARQATKKQNIIVFQGSYHGRTFGTMALTTSKTTYSAGFGPLMPGVHVAPYPYFQQWAAHKADPTKFTPEWCGEEALRQLEILLKQRTSPEDTAAILIEPIQGEGGYVVPPKGYMKGLRALCDKHNILLICDEVQSGFGRTGKMFAVEHTGVVPDILVMAKGIASGYPLSGIVANKALMDLQPPGSMGGTYSGNAISCAAANATLRVFDDEKLLENCNARSEQFFSALRAKIPAALPKGVTVDVRGEGLMIGIEFMGVPYGFANSVAQEALKLDTIVLTTSIYETLRLIPPLNITKEETDLAIDRVVNSIAAASKAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163A1C0</accession>
    <name>A0A163A1C0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_182374</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288451.1">
        <property type="nucleotide sequence ID" value="XM_018438608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163A1C0"/>
    <dbReference type="STRING" id="763407.A0A163A1C0"/>
    <dbReference type="GeneID" id="28999514"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_182374"/>
    <dbReference type="InParanoid" id="A0A163A1C0"/>
    <dbReference type="OrthoDB" id="1932312at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="262"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="308"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD70411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="518" mass="59064" checksum="3F8A066F68ABBDFD" modified="2016-07-06" version="1">MTIINHEEEAVFLNKMLVQLAEYRGGYIQNNSIYQTILGRYQAIMRSKKDRLTTLPAELILCIGHWIALISPQSLGVFGQLNKQIYITLDQSNSKMLWRTALDTAYKCYRTEPSAQDPRATYWTKRHWRHLCANEYSLSPRSLSEDAQHTHQSHSHHPQLTADQKAPILQKHDLAHTRLLDSHMSEYMQYVSTTLNTSTACMQKCVAPFGPDAMSCGTVPYTHSVAVSGTRLLVGCHRLDRVKGQIWVMERMLNGYMLIKTFAGHQNMISCIIATDDKVVVTASLDSTIKVWDVYEDTDSPLVLKHTLRGHAGWVNSITIEDYFLVSGGSDDTVRKWNLRTGEQEGIFRHFYEQDRNLGVLTVSLRHGSIGIGSVFGPFYVMNIETQKMILLEERLTSTEHKTYEQELHQSHSSTIILLSETIITSSRLNNKLNIWDWKGSLLGSLNVEGNLHEVQVSRSEEIMMATTCDGVVKTWDFTLRSRTEQAFMRRLLQGADMEGAPGGSVWLKYSNRFDYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163A4V9</accession>
    <name>A0A163A4V9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="4">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_147611</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TOP6A family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289141.1">
        <property type="nucleotide sequence ID" value="XM_018431917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163A4V9"/>
    <dbReference type="STRING" id="763407.A0A163A4V9"/>
    <dbReference type="GeneID" id="28992823"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_147611"/>
    <dbReference type="InParanoid" id="A0A163A4V9"/>
    <dbReference type="OrthoDB" id="521512at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52041">
        <property type="entry name" value="TOPO_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Spo11/DNA topoisomerase VI subunit A N-terminal" evidence="12">
        <location>
            <begin position="222"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="13">
        <location>
            <begin position="348"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="136"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD71101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="485" mass="54164" checksum="CC072911DDED08D4" modified="2016-07-06" version="1">MNPFYYPWLGPVFPGGQLQGQELCHYNYVHNSNNNNNSSSSSSSSSNNININSNNIYSANEPICGSFNQEQINVDTNFEDLQYSTESSLMSLNINNWQASPNSLNSSAESSSLAILDHFEYNPPGYDIKPEVLDSQVVPEDSPSSQFSRSSNERPQRRYVPLSAGKNSKKRTLDDMNEEYSTQATDTQSTATMSSSSQLGSLGMPGSCNRRVGLFTEAQAKSVARYLRLLEIIYAAIASDTVITKRDIFYRDVTLFGGQNYIDRMVDNICYYFNTPRSSLHIASTASSKGLVCGPITITLKNGKRINCKYSKKSNSGHEDHQGCLVPSFSQITKIELNAKFVIVVEKEDISTRHIVKHISVNFTGIPIMALMDNDPHGLEIYSVYRWGSLSQAFDTANLAPLTKADRDKARGIITMREKFFGSPKGFWSDECPQRNSKSYKEFIKELCAILHINMKCELQGLCVAGGPFAMPRYVEKCLEKFKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AGC8</accession>
    <name>A0A163AGC8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_181489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291351.1">
        <property type="nucleotide sequence ID" value="XM_018438476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AGC8"/>
    <dbReference type="GeneID" id="28999382"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_181489"/>
    <dbReference type="InParanoid" id="A0A163AGC8"/>
    <dbReference type="OrthoDB" id="2253782at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF72">
        <property type="entry name" value="IM:7136021-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="6"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="550"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1189" mass="138247" checksum="100E51F315E07D90" modified="2016-07-06" version="1">MGVPELPFEILINIADNLWKTDIMSCALIYNCSQLPKLIDSIKNSQNISTSHHLMVQSLCLSMHCHWSKIPNIQYSDLFRYLPNLKRLDLEGIKYDDIQADITVSDKIWKSLEILNMTYGGSDEIQPERDLMVEDFDDIHQNLQNLSSITAEIYIYSEFPDALDTVPNTIPAYSVTSLDINSKIYDDGHEEGEEKDYESENININHWNSWWLYYFGYKYPNLRSLKLNVTDMLDDALYPEERKIVLSLFHSNQNAFRHLETFDLKTTRYFDFSDLILWELLCKLRVPLKHLSLDTTYRGKIDYSYPMDVGRILESFSGTLKSLSLTGFTYNQKNEYTIQEMSSCCPFLTNLYISDSSFCLNLDDLLDKCSALEQMEFSGAKLFLSQSRIAEESEQQQQQQHGLRILTLNKCSVAAGVFNYVSLRCRSLEQMTLYTLRIIGSICEKTGCLLFDMSHIFLKTLNIGQSLVEASHNTCWFYTYWDFGYNGLSRTDTAILTKKGVDIALEYYQNFQSSKARSTLSHDTFYNVNYPGSGWKYRLYKGYVEWRFELPYEVLTQIGDNLSTTDRLSCALTCKGWRYPFQDALWRNMPIYTYRRLKKIIETIIASQDVSTPCSLFVKSLRTCTSSYRSEFPDIEFSELFKYLPNLKRLDLGNRNYREIYTEITRSDKVWKTLESLKVKYSADTEMLPEKTIFEFINACSMLQKLEIHERGLGFYMELSVDDFDNMHLNLQNLSSIKAEIYLSCDFLYTLDTIPNTTPAFAVTALDINSKQYENHDGEFSRNWNEWNPLWLYYFGYKYPNLRSLRLEATSICGDEIDLDQRQTIISLFQSNPNAFQHLKTFSFTCDSYFRIADFVLWELFCALKVPLKSLTLDATYNNEVDDSNPMDINRILESFSETLKSLSLTGFTYNEKDRYSILELSSYYPLLTNLCISSEELSLNLGNLFDRCVALKQLKFCGGDLVLNQKTTIEESAQQKQEQYYQHGLQILILHKCSLAAEVFNYLSFRCQSLKHMTLDTVLVKGSLCEKTGCLLLDMSHTFLKTLKIGQLQYSVSNQEMYADYICLTLLSQLNDTPLSKGKSGKDKARIGSKYPTVEHHDIMWLFTYSYRTAFQKSALETKELLEDEVDIALEYYQDFQLNKIISTLMDKNSRVREQQLKYRTYELHKGYGKWNFGNIESGPFICGPDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163AVV0</accession>
    <name>A0A163AVV0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_59697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294201.1">
        <property type="nucleotide sequence ID" value="XM_018440543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163AVV0"/>
    <dbReference type="STRING" id="763407.A0A163AVV0"/>
    <dbReference type="GeneID" id="29001449"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_59697"/>
    <dbReference type="InParanoid" id="A0A163AVV0"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47941">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="133"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD76161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="46530" checksum="880C85095F43C4F2" modified="2016-07-06" version="1">MAQNALLSTRGYLQRKWAPALTQLTCAAYGTSATQWFRRFLSPKEEKDLYLGLTATFRDKLTEKTTYSAKSYSNIIEQAILNGRNHPNLPPRGKLSHERMQEIPHAIDLAGKIQDTTQLEAIQREMEEAEISTVTLYNRLIRGFIQSNAIELADNVFERLQSNHLLPTTRTMTYLIRAHVKKNNLEKARLYVEKMQHLSLNKLRTAFDYSVMLEYSIINGDSHAVDFLWRDILKYAEIVKPGMGLYTQHLDYLTFRPELHSNLAEVAEEMLRRGVASPTSFQWNPHAGQILSKTVFTLAQNPEYATTSSQLLIFLIKASPHPWQPLSPLDQSINLIINAFLKRGQDLKALAFYYRLKRHNAPDNAFSAETTRSISDVLSKAEHRQHMDASQENKAILAEFSLLGQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163B787</accession>
    <name>A0A163B787_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCFS4-like zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_163720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296661.1">
        <property type="nucleotide sequence ID" value="XM_018434861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163B787"/>
    <dbReference type="STRING" id="763407.A0A163B787"/>
    <dbReference type="GeneID" id="28995767"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_163720"/>
    <dbReference type="InParanoid" id="A0A163B787"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045154">
        <property type="entry name" value="PCF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057242">
        <property type="entry name" value="PCFS4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921:SF3">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23228">
        <property type="entry name" value="zf_PCFS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="PCFS4-like zinc finger" evidence="3">
        <location>
            <begin position="239"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD78621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="373" mass="41211" checksum="8980CA607E5A3093" modified="2016-07-06" version="1">MSQVLAATPQTAFVPPVPQPIRLSHPPPKPAPVNTGDLLKNLASMGFLGNPTNGIATPSSTPERIADKSQDVFGPFSFDSKDLQMCVLEFSVYNLISKSFLLTPTFLFCRSLHHLQPTKINLYFRPRAGAVELLYSNLPLQCKQCGFRYPKTDEGQAKMDAHLDSHFRQNRRMKERVKRGLSRSWFVTESEWISGAGGEVTSQQAPAFLNDQSSGHLNNNEKSSGVHGSTEDANMAEDHKVVMPNDGRKPCPICGERFIDFWNDEEEEWMYKNAVLVENTVNTLNIIIISIVIIITGVAVAVAVAVTVVTALIYHATCHADAIKSGTLVFGDSSMDITPQEQEIDNVNNIPSSLKRKAEEGDVEMDHKVARTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BB57</accession>
    <name>A0A163BB57_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_162454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297421.1">
        <property type="nucleotide sequence ID" value="XM_018434629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BB57"/>
    <dbReference type="GeneID" id="28995535"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162454"/>
    <dbReference type="InParanoid" id="A0A163BB57"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="102" mass="12310" checksum="5ABC9645A568F5C2" modified="2016-07-06" version="1">MIYHKNCDDISSIIYIFGTFDPDEITLFFQCYIYKWMTANLLNTKYVSLCLAILCLIYQVMSNIMHEDNVSLFKDYWYCLDNSEKHVYINFMSSLLRLHSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163BE35</accession>
    <name>A0A163BE35_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_62034</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299031.1">
        <property type="nucleotide sequence ID" value="XM_018440890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163BE35"/>
    <dbReference type="FunCoup" id="A0A163BE35">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163BE35"/>
    <dbReference type="GeneID" id="29001796"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_62034"/>
    <dbReference type="InParanoid" id="A0A163BE35"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17325">
        <property type="entry name" value="MFS_MdtG_SLC18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="50"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD80991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="512" mass="55527" checksum="625B1814CFD1450D" modified="2016-07-06" version="1">MSSHTLRSSNIISQFISEENTSKDQTPIKDDGIEPKKPFCYRIRSSKAFVFSTAAIGVFTSNFVHSILFPLAPFIVARINNGGKETSETEVASSAETGILVAAYAIGLLSGSPVFGWLGDRLTLRRLPMLLGISVSIGANLLFMFSTAYWMLLLARFLQGFSNACVWTMCLCIVTDNWPSDELGKCYKDEDASMGTYTISLGLQMGKLMGLYASGMVIGLPVGGVLYSELGYQAPFIASLIICAIDFFMRIAIIEKPVFSKTWPLNTPTISEEDGYSNEKPKPNTIRPNFDDAPLMNPVQNAKLSKLLRQPRLLVSLFQMAVVASTMSSFEPTISMWLASEWHFNAAECGLILLAYILPCIVSSVFSGWLCDKIGTKAVAVVSLSFAASTCVCVGIPNHTNSFWTLVPVLAVSGAAIAGCESSVFPEVAKVIATENNNPDDHSGIARCYAMVNVASAIGLCVGPLLAGFLYSAIGFFWLCCLLSIPFVICIPFAYFYVGGSNTKFIVRPPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163CUG3</accession>
    <name>A0A163CUG3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_153138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441008">
        <property type="protein sequence ID" value="OAD65660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283700.1">
        <property type="nucleotide sequence ID" value="XM_018433075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163CUG3"/>
    <dbReference type="GeneID" id="28993981"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153138"/>
    <dbReference type="InParanoid" id="A0A163CUG3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD65660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="353" mass="39788" checksum="C45757D0D401A292" modified="2016-07-06" version="1">MPSNATRKSGRKGKQNARGTLSRVAAGRIEQREIAPRVSPLAAGPSGAEAPGMTVESLTQVMAAINMMYDRTVEANTGIRFLVDAHNQAIAQQALVASSVTQGVTAANVSTNRHTKGEMCAIVLNLINGRMWARNFRSNDPELVAENESRRRWNTDERIDHPDNVEVINYLRQYIVAQPRTAGFWEDMIVQKIKNNYKTCFRAVNATPEQASSKRRNNRINSHRIEIHLRRVDTYINNWLAIDTKMGYKPGNPDEMAYLHLLEKSVMSDGESEDEDVTPIIRVRVLQVARPSWRSAELNRLIQFIDFLAAENDKKIATPQSKQRMPRYLKIIAVTPVPGHLTAILPVWAIQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163CVS7</accession>
    <name>A0A163CVS7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_128758</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441007">
        <property type="protein sequence ID" value="OAD65950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283990.1">
        <property type="nucleotide sequence ID" value="XM_018429241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163CVS7"/>
    <dbReference type="FunCoup" id="A0A163CVS7">
        <property type="interactions" value="619"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163CVS7"/>
    <dbReference type="GeneID" id="28990147"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_128758"/>
    <dbReference type="InParanoid" id="A0A163CVS7"/>
    <dbReference type="OrthoDB" id="1724687at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047861">
        <property type="entry name" value="Ribosomal_eS7_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00948">
        <property type="entry name" value="RIBOSOMAL_S7E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD65950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="194" mass="21616" checksum="F815C6F8F6A93967" modified="2016-07-06" version="1">MASNKIAKPAGAAPSDEFELSVAQALVDLQNNVPELKKDLKALQISGAKEIEIGGGKKAIVVFVPVPSQKAFNKIQARLTRELEKKFSDRHVVFIAQRRILKTPTRRENPKQPRPRSRTLTAVHEAILEDLVYPTEIVGKRTRVAVDGSKTIKVFLDTKDATSLEYKLDTFSAVYKKLTGKDVVFEFPANVDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DBB6</accession>
    <name>A0A163DBB6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_91105</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288190.1">
        <property type="nucleotide sequence ID" value="XM_018443764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DBB6"/>
    <dbReference type="STRING" id="763407.A0A163DBB6"/>
    <dbReference type="GeneID" id="29004669"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_91105"/>
    <dbReference type="InParanoid" id="A0A163DBB6"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="129"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="8">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD70150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="269" mass="30562" checksum="38F842FD771BE81D" modified="2016-07-06" version="1" fragment="single">YQLLEELGRGSYGCLFLGQSLDTNQYVAVKVLSKAGLDTNQRTLQQLEIDIQSSLHHPYLLSIHQTTQDEDHIFMVMELCDQGDLFDFVIRDPLKLCDQSLVKTLFGQILQAIEHMHSNHVYHRDIKLENILLKCDDDDQYTCKVADFGLATRERLSLEFGCGSTTYLGPEHFDDEDNGDDEKEAEEFVPYDAAASDCWSLGILLIALMFGRNPWEEATTMDPSYAEYIRDPLMLAHLFPTLSNGCLDFLISVLDVRPQDRPSVSAMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DCN9</accession>
    <name>A0A163DCN9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_70630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288490.1">
        <property type="nucleotide sequence ID" value="XM_018442312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DCN9"/>
    <dbReference type="GeneID" id="29003218"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_70630"/>
    <dbReference type="InParanoid" id="A0A163DCN9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="250" mass="28310" checksum="4B2486E0C00D57E7" modified="2016-07-06" version="1">MIPKAFTNTNVFKTVLPRQNGWLNTLCLRERPVKSHYGRPANTHNRTRRTVTSTSKLNALIPQNSSLIEKLCAVNEHIFRHKFPVLQPSPPPSSHPLLFLSATKKATGKESKHSKLTTAQASRAIQPESRPSVYSFVYLPYCNHLKYSQVRKLLRTLKIQQSYSGMSVKTAFDTLDRRIHCWSDTPTKLTMCANDLSTSYTANVFSPSAFVSLPSTLSSIWKIELFCLACPKSGFKSHREFMKYSGKANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DJL3</accession>
    <name>A0A163DJL3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">U6 snRNA-associated Sm-like protein LSm1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LSM1</name>
        <name evidence="13" type="ORF">PHYBLDRAFT_134687</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a donut shape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289750.1">
        <property type="nucleotide sequence ID" value="XM_018429664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DJL3"/>
    <dbReference type="FunCoup" id="A0A163DJL3">
        <property type="interactions" value="301"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163DJL3"/>
    <dbReference type="GeneID" id="28990570"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_134687"/>
    <dbReference type="InParanoid" id="A0A163DJL3"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01728">
        <property type="entry name" value="LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000021">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034104">
        <property type="entry name" value="Lsm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF8">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="10"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD71710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="137" mass="15496" checksum="3B3A75956F3080F3" modified="2016-07-06" version="1">MEITSGPLFTTSTGLIDSVDKKLMVVLRDGRKLIGTLRSFDQFANLVLQDTIERIYVGNCFGDIPRGIFIIRGENVVLLGELDTEKEECANLREVPVEEILVAQREEMEAKQRLDKVRSKALHNHGFCVDNAQNDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163DJP0</accession>
    <name>A0A163DJP0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_147487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289770.1">
        <property type="nucleotide sequence ID" value="XM_018431876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163DJP0"/>
    <dbReference type="STRING" id="763407.A0A163DJP0"/>
    <dbReference type="GeneID" id="28992782"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_147487"/>
    <dbReference type="InParanoid" id="A0A163DJP0"/>
    <dbReference type="OrthoDB" id="10044727at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD71730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="666" mass="77961" checksum="61245CBC0B37C775" modified="2016-07-06" version="1">MPRPKKRSTMAKKINRSASSGAFIKKIQLENEDYVDLEFDHEDDIVLDDRALQGMSEEVTSAAYTNQLLKWHECADKSLRRTYQKNSRTTEWRKRKADNDASNTQGSYRLTDKGFFIKVQKEAPIELKESIDSELENIQIDKIAVLKLAHEDVKKEIFPYTRAGPSSQSVDAFELCKLKSVECYLRYRISGAKTMEASEKASMETWLHKNTYRPAAIRKYAKEYVDFRSIALHQQGKHLRRHSLFSDEYIKSTICKWIQNQRPESRSLIEVKKYIDGEILPRKLGMPGNTSTNTIWKYLHEWGYVFRKNSKDIYYDGHEREDVIAYRQKWAKRMMVYKKKMATFSENEETVVLPVLRSDEIEHVLVTPDESTFYANDGKDTMWLMEDENPIRKKGPGMSLMISEFKCVCHGTMARGAWSSREVFRPGADRDGYWTSVDMLKQLKNNVIPLFELIHPGCKAVFSFDQSTNHKEYGQNALISSKMNLNDKEIEDDDPCSLQDTVFVRNGVEEVQSMYYKKDEWFAKKSGQWVQNKVKYVKGVRHILKERGLWLEKDPYNPIKKWRLDCKSKDASEDSKCCAHHFLASQPDFMSQKTALHEAVEDSGHIFELYPKFHCKCNWIERYWGAAKREAHLQCDYTYKSLDKNIHTFLDHAGKLPNIRQYYNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163E4X2</accession>
    <name>A0A163E4X2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_142175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294700.1">
        <property type="nucleotide sequence ID" value="XM_018430752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163E4X2"/>
    <dbReference type="GeneID" id="28991658"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_142175"/>
    <dbReference type="InParanoid" id="A0A163E4X2"/>
    <dbReference type="OrthoDB" id="10386085at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="147" mass="16272" checksum="FB0672E4DCCDF240" modified="2016-07-06" version="1">MEDTHSHHKLGQMLYLFSTLRNGAIAVSRFAWVLYLEIYKRYPPVRWTGNIIQRLSTPPLVVFLFVLISSLVFLLSIATVLVLSIQTGIILACGSVLLPILGIICGLALTILGGLTCLFVFAQATVAFVKPILLHVGLALRKDKRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163E6I7</accession>
    <name>A0A163E6I7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Pyruvate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_180269</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295030.1">
        <property type="nucleotide sequence ID" value="XM_018438287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163E6I7"/>
    <dbReference type="FunCoup" id="A0A163E6I7">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A163E6I7"/>
    <dbReference type="GeneID" id="28999193"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_180269"/>
    <dbReference type="InParanoid" id="A0A163E6I7"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="12">
        <location>
            <begin position="7"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="10">
        <location>
            <begin position="203"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="11">
        <location>
            <begin position="396"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD76990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="62219" checksum="9EBA819CF7FC1990" modified="2016-07-06" version="1">MSTYKITIGQYLLNRLKDIGIDTIFGCPGDYNMPFLDLIEDDGQLTWANDANELNAAYAADGYARIKGAGAVVTTFGVGEMSAANGTAGSYSEMVPVVHIVGTPNTKAQSSGAILHHSLGNGNFNVFLEMFAKITVASTQLDKKNALSEIDNVLIAMMRSRRAAYIGLPIDLVKFEIELSEPVSPLDTSLPKNPRNTQNDCLQVVLEAIKKAKNPIILVDACALRNQLTGVVKELCEKSKFPTFVSPMGKGAVDDTADYYRGCYCGSVSLAEVHKEVQDSDLILEVGSVQSDFNTGGFTYKVDRSKIIAFHTFATNVYRATYEKVGMSELLPLLIKELPQYPSRTYPPVPRPQDIKHDSQEITHNYFWNKVPDFMDTNAIVVAETGTSEFGVFNMNAPKGASFITQVLWGSIGYSVGAAYGAAMADRSRRVYLFVGDGSFQMTVQEVSAMLHQGLTPVIFLLNNDGYLIEKLIHGPDRDYNNFQMWKYAKTLDYFGADLPVNTSKPKQSKVGVQAKLSTRKEFEAAMTLVSEQKDRIHFLEIVMPRFDAPRELLLQVETSDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EJP2</accession>
    <name>A0A163EJP2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Basic-leucine zipper transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_141020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297000.1">
        <property type="nucleotide sequence ID" value="XM_018430505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EJP2"/>
    <dbReference type="STRING" id="763407.A0A163EJP2"/>
    <dbReference type="GeneID" id="28991411"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141020"/>
    <dbReference type="InParanoid" id="A0A163EJP2"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000053">
        <property type="entry name" value="BZIP transcription factor AtfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000837">
        <property type="entry name" value="AP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00042">
        <property type="entry name" value="LEUZIPPRFOS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="193"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="218"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD78960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="263" mass="30323" checksum="FE91F7D10FA8BF16" modified="2016-07-06" version="1">MVNNQSNQITPNFTGWRFTGSKNDSRSTNVPNQTGKEHTNQSQLILDLSYPTNCVQKVPPKLSLLAERNPFETSFSQVLSPTSRQPWQFSGRLNKKTEAEKQTLKRQLAPTEPRPDLSELMKHSQTITKPGSQSQSQSQSQSQPQPQPQRKRYRKSQTPAYDPKYELTQEPTPSPTCPKQALSSKQPIDPSEKEKRASFLERNRQAALKCRQRKKQWLNSLQDKVEFLSEDNRQLQLETARLKEEVMYLKELLAFHNCQPSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163EKL6</accession>
    <name>A0A163EKL6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ras-related protein Rab</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_120994</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The small GTPases Rab are key regulators in vesicle trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297160.1">
        <property type="nucleotide sequence ID" value="XM_018428775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163EKL6"/>
    <dbReference type="STRING" id="763407.A0A163EKL6"/>
    <dbReference type="GeneID" id="28989681"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_120994"/>
    <dbReference type="InParanoid" id="A0A163EKL6"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04107">
        <property type="entry name" value="Rab32_Rab38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000222">
        <property type="entry name" value="RAB32, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030697">
        <property type="entry name" value="Rab29/Rab38/Rab32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF39">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD79120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="217" mass="24500" checksum="8302BCF40CDFE480" modified="2016-07-06" version="1">MSEVREYLYKILVVGDLGTGKTSIIRRYVHNIFSSNYKSTIGVDFALKVIQWSPEIIVRLQLWDIAGQERFGNMTRVYYKEALGAFVVYDVTRPQTFEGVTKWKHDIDSKVTLPEAWGGGNIPVVLLANKSDLIHEGHGQQVNAEDMDRFCAEQGFLNWFETSAKEDTNIDEAARHLMTAVLKIEEEHGSDLAQDEAERIRLDQLNKQSEAGSGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163ET35</accession>
    <name>A0A163ET35_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_138960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299450.1">
        <property type="nucleotide sequence ID" value="XM_018430117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A163ET35"/>
    <dbReference type="GeneID" id="28991023"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138960"/>
    <dbReference type="InParanoid" id="A0A163ET35"/>
    <dbReference type="OrthoDB" id="2285535at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD81410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="363" mass="41634" checksum="112EC0AB7EC5AD31" modified="2016-07-06" version="1">MQLEGMHDIIMQVVSDENWPIIALGHSVEPKEAKVWVSRKVNVKLKEKFDSDLSIILCRNSQQEGDSTLQFHECPNHILSKSKEFANNLGFPYQGFTRELSLDTAVNNELCQLVNGRKVTKSANVPSDLVQSWNIYRALITNAIYNQSLQSGASQCLSEAFTEPAGCYTNPICASTLQELQESLVTNIRQLLKSHLPDKVTFATLSAHPEKHISAFSQILFEYELKHTNHNPFVLLVQMHYPAFCPDHYQEDAITKWQQSNHVWKFNKIKWIFPLIAYSTRGTQLPSKADKTMQLKLGRKSKMELKPLKVIYHPTRQSPMQHMLTAYSIFSLTWTCYMIFMALALPNISFFDIKGPRKLPSKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167J3R7</accession>
    <name>A0A167J3R7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_153836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441040">
        <property type="protein sequence ID" value="OAD65059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283099.1">
        <property type="nucleotide sequence ID" value="XM_018433272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167J3R7"/>
    <dbReference type="GeneID" id="28994178"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_153836"/>
    <dbReference type="InParanoid" id="A0A167J3R7"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD65059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="158" mass="17996" checksum="F81691D1257B023B" modified="2016-07-06" version="1">MTRSYLSRFSHVLRVSIDIICHTKRSILYLTSEYSQIVLWHAPVVITLGHMSSYCREHVDSLLCRFLRRNMLSMAILSSMFSETAKRLRRVGLADSTEILWGPSPSFVGCNTANHIFKDKEWCTFHSHLLDGVTYTASSAPNTSGWKRINASGAFMFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167J7Q9</accession>
    <name>A0A167J7Q9_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase SUB2</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ATP-dependent RNA helicase sub2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PHYBLDRAFT_160840</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 also plays a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DECD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KV441028">
        <property type="protein sequence ID" value="OAD65417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283457.1">
        <property type="nucleotide sequence ID" value="XM_018434269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167J7Q9"/>
    <dbReference type="FunCoup" id="A0A167J7Q9">
        <property type="interactions" value="963"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167J7Q9"/>
    <dbReference type="GeneID" id="28995175"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160840"/>
    <dbReference type="InParanoid" id="A0A167J7Q9"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17950">
        <property type="entry name" value="DEADc_DDX39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000111">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000168">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase 56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="84"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="287"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OAD65417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="436" mass="50001" checksum="08F6D624965CD7D8" modified="2016-07-06" version="1">MSAADHTDDLIDYDEEEEHIVQPKTTHNEPETTGADDESKKDKKGSYVGIHSTGFRDFLLKPELLRSIVDCGFEHPSEVQQECIPQSILGMDVICQAKSGMGKTAVFVLATLQQIEPVDGDVSVVVLCHTRELAFQIKNEYARFSKYLPEIRTEVFYGGVPMTKDVETLKDKTKCPHILVGTPGRVLALVRDKYLKLGNVKHFVLDECDKMLEQLDMRRDVQDIFRSTPHHKQVMMFSATLAKEMRPVCKKFMQNPLEIYVDDEAKLTLHGLQQFYIKMDEREKNRKLNELLDTLEFNQVCIFVRSVPRANELNRILTDCNFPSICIHSQMSQDERIKRYKSFKDFEKRIMVATDIFGRGIDIERVNIVINYDMPDSADTYLHRVGRAGRFGTKGLGITFVSDDKDSEILNAVQSRFEINIVPLPEDIDINTYMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JEF7</accession>
    <name>A0A167JEF7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_128821</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441027">
        <property type="protein sequence ID" value="OAD65828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018283868.1">
        <property type="nucleotide sequence ID" value="XM_018429246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JEF7"/>
    <dbReference type="FunCoup" id="A0A167JEF7">
        <property type="interactions" value="703"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167JEF7"/>
    <dbReference type="GeneID" id="28990152"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_128821"/>
    <dbReference type="InParanoid" id="A0A167JEF7"/>
    <dbReference type="OrthoDB" id="1937934at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22455">
        <property type="entry name" value="KH-I_Rnc1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22456">
        <property type="entry name" value="KH-I_Rnc1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22457">
        <property type="entry name" value="KH-I_Rnc1_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049786">
        <property type="entry name" value="Rnc1_KH-I_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="35"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="126"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="293"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="242"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="259"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD65828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="387" mass="41387" checksum="CC1E61947EEF6563" modified="2016-07-06" version="1">MSQPSNSSSDHYDDRFIPNASQENDGDQQYDYDDAQLTLRALVSTKEAGVIIGKAGKNVAELRDSTGVKAGVSKVVQGVHDRVLTVSGTLEGVAKAYSLIAQTLLDNPISPATPPATPTGTSMVDLVATIRLLISHNLMGTVIGRQGAKIKHIQDTSGVRMIASKTLLPQSTERVVEVRGTVDSVRRAVVEIGQCLIEDKERAYGTILYNPTKGSMSIVGANGAGVGNVSSSVLSSSVANSATNSANGGSNGPDRRSSITRTGNGSDFSSAPTDYQTQRRPSATSQNFLNDPSIRTQHISIPSDMVGCIIGKGGSKISEIRRLSGSRISIAKVPHDETGERMFTIQGTPDSNERALYLLYGQLENEKERRLRSVMHEDILEEDEVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JL18</accession>
    <name>A0A167JL18_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_152789</name>
        <name evidence="4" type="ORF">PHYBLDRAFT_175511</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441005">
        <property type="protein sequence ID" value="OAD66216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV441005">
        <property type="protein sequence ID" value="OAD66219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284256.1">
        <property type="nucleotide sequence ID" value="XM_018432995.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284259.1">
        <property type="nucleotide sequence ID" value="XM_018437511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JL18"/>
    <dbReference type="GeneID" id="28993901"/>
    <dbReference type="GeneID" id="28998417"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152789"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175511"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD66216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD66219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="183" mass="21378" checksum="AD7D84D3F707B350" modified="2016-07-06" version="1">MFAIANPDEVRCKCTRCNRNHLRYTMTDKRTAKRHAQNDNDRNMDKTINEQIVLTAKVNTGEADIDVDQIEEHIEYDNYSVGAPSPEQYVNTNLPLLVEESLFETEEHTSEYESEYESSDEFEQEEQNREQEQESTENLSENIWHRVIAVFTVIFISSFIVDEGAIILITFINTILEHYGEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JM94</accession>
    <name>A0A167JM94_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UBR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_152624</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441004">
        <property type="protein sequence ID" value="OAD66297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284337.1">
        <property type="nucleotide sequence ID" value="XM_018432965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JM94"/>
    <dbReference type="FunCoup" id="A0A167JM94">
        <property type="interactions" value="639"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167JM94"/>
    <dbReference type="GeneID" id="28993871"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152624"/>
    <dbReference type="InParanoid" id="A0A167JM94"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15542">
        <property type="entry name" value="PHD_UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19677">
        <property type="entry name" value="UBR-box_UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040204">
        <property type="entry name" value="UBR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047506">
        <property type="entry name" value="UBR7-like_UBR-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="7">
        <location>
            <begin position="41"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="131"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="5">
        <location>
            <begin position="41"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD66297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="42618" checksum="599733FF268F0211" modified="2016-07-06" version="1">MSLPCSPTLKSSDDTITAVDFISQQTILEQDAREALPGNFETCTFDMGYIRQNVYACKTCNGSEPAGMCYSCSMTCHNGHDILELFPKRHFRCDCGTPSKLNGHPCSLSKGTPKEKKTVNEENKYNHNFYGKYCRCDELYDPDREDDVMYQCVVCEDWFHQRCIGEIPDFAADFESYICRGCTAKHPFLIQDTPYCTVGLSKDNQKIHEWMPTKENIEVVSVEESVGQQKRKADTIIDTDPKKRKTDKFDCKMRSYESQVELFLASGWRSGLCSCNKCEENYQTNELGYLKEEEKVYEPEDDDDTGKSLLEAGMEHFQRMDRVQAVESALAYNAFAGELKQYLKKFQEAGEVVKKEDILAFFAEKRRVEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167JUQ4</accession>
    <name>A0A167JUQ4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type zinc finger transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_174783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441000">
        <property type="protein sequence ID" value="OAD66746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284786.1">
        <property type="nucleotide sequence ID" value="XM_018437338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167JUQ4"/>
    <dbReference type="GeneID" id="28998244"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_174783"/>
    <dbReference type="InParanoid" id="A0A167JUQ4"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD66746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="260" mass="29581" checksum="E4B978A2B8F1B662" modified="2016-07-06" version="1">MSSSNASQQRDRISTQQYQCDQCVLFFDNYQKLQNHKRIHRGDSATMTEIDQSILDDVDMYHDKNDTSNEDESVSNSEYTMESMELDNTISYKCACNFEDSEGEAHIYDSSRISTNTFTKAKLMSIHLSQLMLQHRIARAAYRDIVQFINTVIRDHDDIMMEPGAKISHGETVDALLKSRSSVKGHEYDVCSSGCRLYGINDDQKSCTDPDQSQTPAASMKIMSVGDMLSQMLEDPATRELHCYRSNWESVAGQLTDIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K4G9</accession>
    <name>A0A167K4G9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_63744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441024">
        <property type="protein sequence ID" value="OAD67260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285300.1">
        <property type="nucleotide sequence ID" value="XM_018441167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K4G9"/>
    <dbReference type="GeneID" id="29002073"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63744"/>
    <dbReference type="InParanoid" id="A0A167K4G9"/>
    <dbReference type="OrthoDB" id="3261594at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD67260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="218" mass="24672" checksum="37FD71C0D58D9503" modified="2016-07-06" version="1">MHINSGVVIDVEFGQDVPTDIKTPLESGHGYFHVHNTVNHVDFPSQYESDESDESKLDEAPRVSHYELMNGAEAASLELFFMFVENNVSHNVFDKCVKMMNKYMAECELSAANSLMSYYKMDILLRQEYTVRPVTHDIYERDNMMQLAIILGPEHPKNIASFLEPIVEDLHMLQTSGLRVQTNSGQVSVKVHFVMATGNNPAVSDLMKLAHHNSFFGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167K9M0</accession>
    <name>A0A167K9M0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_128111</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285588.1">
        <property type="nucleotide sequence ID" value="XM_018429202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167K9M0"/>
    <dbReference type="FunCoup" id="A0A167K9M0">
        <property type="interactions" value="730"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167K9M0"/>
    <dbReference type="GeneID" id="28990108"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_128111"/>
    <dbReference type="InParanoid" id="A0A167K9M0"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03753">
        <property type="entry name" value="proteasome_alpha_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000015">
        <property type="entry name" value="Proteasome subunit alpha type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033812">
        <property type="entry name" value="Proteasome_alpha_type_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD67548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="244" mass="26583" checksum="4A431EAEEEE18D9C" modified="2016-07-06" version="1" fragment="single">MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGTTAIGIQTSEGVILAVEKRVSSTLLEASSIEKVMEIDVHLGCAVSGMTADARTMIEHARVAAQNHRFTYEESLKVESVTQSVCDLALRFGEGADGEDSIMSRPFGVALLIAGIDEKGPQLFHADPSGTFMSYQAKAIGSGSEGAQTELQKEYHMSMTLQEAETLSLTVLKSVMEEKLNKANVQLASVTPGRHFRVYGEEELQAVIDRLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KA84</accession>
    <name>A0A167KA84_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="8">2.7.7.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_118339</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="8"/>
    <dbReference type="EMBL" id="KV440999">
        <property type="protein sequence ID" value="OAD67587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285627.1">
        <property type="nucleotide sequence ID" value="XM_018428627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KA84"/>
    <dbReference type="STRING" id="763407.A0A167KA84"/>
    <dbReference type="GeneID" id="28989533"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_118339"/>
    <dbReference type="InParanoid" id="A0A167KA84"/>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="9">
        <location>
            <begin position="7"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD67587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="182" mass="21358" checksum="5AC79F229052D0BE" modified="2016-07-06" version="1" fragment="single">DRPVRIYCDGIYDLFHFGHAKALEQAKKAFPDVYLLVGVCSDKETHKRKGKTVMTDNERYEAVRHCKWVDEVVTDAPWIVDQDFLDCHKIDYVAHDAEPYQSRESGDVYAFVKDQGRFLPTERTEGISTSDLITRIVRDYDAYLRRNLERGVSAKELNISFLKVKHNQYIQVYTYTYIHIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KF55</accession>
    <name>A0A167KF55_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="13">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PHYBLDRAFT_68328</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="13"/>
    <dbReference type="EMBL" id="KV440997">
        <property type="protein sequence ID" value="OAD67956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018285996.1">
        <property type="nucleotide sequence ID" value="XM_018441930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KF55"/>
    <dbReference type="FunCoup" id="A0A167KF55">
        <property type="interactions" value="650"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167KF55"/>
    <dbReference type="GeneID" id="29002836"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_68328"/>
    <dbReference type="InParanoid" id="A0A167KF55"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000020">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="18">
        <location>
            <begin position="52"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="200"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="456"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="557"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="639"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="15">
        <location>
            <begin position="686"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="1060"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OAD67956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1149" mass="129041" checksum="BB7A870980C21C4C" modified="2016-07-06" version="1">MEVDSPKECDKDHDHTHSKDGFEPLKQEYFEGKHLSEPDKWKLLPAFLRVKGLVKQHIDSFDYFINTDLRKIVKANEKITSDVDPNFYLKYTGIRVGMPERTDTDVANRSYTPHECRLRDLSYSANIFVDVEYTRGKQIVKRKNVIIGRMPIMLRSSHCVLRGKNEAELARMKECPLDPGGYFVVKGTEKVILVQEQLSKNRIIVDVDKKGNIIANVQSSTHERKSKTAIFVKHGKIYLKHNSIAEDIPVMVFMKALGIQSDREIAQLVCGNDHDLHDAFAINLEESSKLRVFTQLQALEFIGSKVKVNRKLATYRKTLAEEALEVLATVILAHVPVENLNFREKSIYASVMIRRVLVAMGDEVQVDDRDYVGNKRLELAGQLLSLLFEDLFKRFNSDLKMNADKVLKKPNRTQEFDIFNQLMLHGDHITSGFIRAISTGNWVLKRFKMDRAGITQVLSRLSYISALGMMTRISSQFEKTRKVSGPRALQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTDDEEDPIRKIAYALGVEDINMLTGAEIYQPNTFVVMMNGVILGVTQRAQKFVTDFRRLRRAGRLSEFVTVFVNIHQRTVNLSSDGGRICRPLIIVDKGKPRVTQQHIDDLIAEKLVFDDFLKKGLVEYLDVNEESDANIATYEADIIPQTTHLEIEPFTILGAVAGLIPYPHHNQSPRNTYQCAMGKQAIGAIGYNQLNRIETLIYLMVYPQQPMVKSKTIELIGYDKLPAGQNATVAVMSYSGYDIEDALVLNKSGLDRGFGRCQVMRKYATLVKRYPNATHDRLADPPTQDSDLWNPSYDAIEQDGIAGVGEPLEAGSIFVNKQVPTSSGLDPGVASSAQTVSYKSAPMRYKSPQTGYVDKVLFTTTESDQTLIKVNIRQTRRPELGDKFSSRHGQKGVCGIIVQQEDMPFADTGVCPDIIMNPHGFPSRMTVGKMIELLAGKAGVLAGKLQYGTAFGGSKVEDMSRILMDHGFNYSGKDYVTSGITGEPLSAYIFFGPIYYQKLKHMVMDKMHARARGPRATLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEVHVCDVCGLIGYAGWCQYCKSSKSIKKMQIPYAAKLLFQELMAMNISPRMILEDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KKG5</accession>
    <name>A0A167KKG5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_127613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440995">
        <property type="protein sequence ID" value="OAD68297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286337.1">
        <property type="nucleotide sequence ID" value="XM_018429177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KKG5"/>
    <dbReference type="GeneID" id="28990083"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_127613"/>
    <dbReference type="InParanoid" id="A0A167KKG5"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD68297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="70" mass="7903" checksum="D9A45BE37BB42EB3" modified="2016-07-06" version="1">MLFLYLAAVATSSRKIMPRHINQKLQESSRKNMVLMFCNGHPTALTLAPLRIYGESLITESEQDAPDQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KV76</accession>
    <name>A0A167KV76_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PAP-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_172802</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440993">
        <property type="protein sequence ID" value="OAD68966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287006.1">
        <property type="nucleotide sequence ID" value="XM_018436874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KV76"/>
    <dbReference type="STRING" id="763407.A0A167KV76"/>
    <dbReference type="GeneID" id="28997780"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172802"/>
    <dbReference type="InParanoid" id="A0A167KV76"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAP-associated" evidence="5">
        <location>
            <begin position="94"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="438"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="518"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="580"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="527"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="595"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD68966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="686" mass="77924" checksum="0B4B16E5F4540408" modified="2016-07-06" version="1">MSLWYLMNCDPPVIPNLQNISQDNSCKAPFCNAKVSLNKWIIFQKRVIECNVAYHNCVNVVHTDRPEYDIEYTSKNSIFTSQETIWKCENVETVGSLLKGFFNYFGREHNFSQYALSLRFGRLIPKWEWKDSHMAVEDPFIIGRNVAGTSTFLGTNTIRNEFKRAYDLLNSNHTFADITGPVDPNERIFDPDTIEQRIIQRNFQQMNRTRRNIGNYDYIHRQSEIVYNELHNPRRRRKPATNLNITKTGYFPQNDREANIPSKLTSTQSSMYYQEPTYSKTSKEDTEIDFEAIASIVEDHTPKKTVVSQYTPIDDNSNTKQKAVDVHNTTTGVKIPRSIIQSSSTNSTDSEETASRLYAKTPPEISRTIQQMFPKMPQEKEVQAGKYQPISNRSPSSTYAEITSPHGAPEALQNLQRPAFQNITPSFSSVVADNIKSPRPIGSGNQQKEIKPAKPAKPARTVKPVETANPVESVKYTKPVKPLNNIINFHDSVNTFKETTYKRVVGFKNKIAPEHPTHLAFTDKPSPKNTTASQIKSPTPTHMSIVNGALKALDPFQFSKTKNKKLFEIPEILEVSDSSVTTNSQYDDSINKEEDCGEGDDDEGGGDTCSLLDVPDFVDAFDILDVLTQYGDVLSLESERLSKPESLYTFLHWRFTINLYQDIDALPKKIELADEYFTILNKPNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167KXP6</accession>
    <name>A0A167KXP6_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_172379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287166.1">
        <property type="nucleotide sequence ID" value="XM_018436788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167KXP6"/>
    <dbReference type="GeneID" id="28997694"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172379"/>
    <dbReference type="InParanoid" id="A0A167KXP6"/>
    <dbReference type="OrthoDB" id="2283774at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="145"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD69126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="764" mass="89515" checksum="647DA3D8E9D0E714" modified="2016-07-06" version="1">MSINLIFIKPFQNRKYIIETRYTTQILYRICISGICVNKRKEERKQERKGVVFISYFRVAFCNRNNSKNQKKHLGYSKALSNSYVLLATALKLKAQSLSLEAQRTTETPLIYGNWRAILLLQVEPLIIFTQSHPSLFVSMLLSKLPPEVILNISLFLPLKDRDSCCFVCRAWKGPFQESMHYDLTLGSIGAIYNSWEELVDSESIKQYTGTLLRSLTLSDCRNLSVQQLGTLQRTFPNVKSVWIQKLCCSSNLFERETDWLLWRSLTELRVDILLYRTIHVEVDNPFLGIICNLSMLTRLQLINSVHYESCINQIFRLSEFELIHTRLVHLTHLELSSRLLSISGTEIQRMGEVSPANKIKLFRMISSKTDHQWLYYFAKKYPNLESFNFSTISDELESEKQRNNIISLLQSLTHPFQHLKALYLGDKNYLPKEYLLYYDMINCFKPPLERIYIYIFQRNLFGNLSKPLSALNKLFRYMCSSRLSGSLKDLCVLCPEVLIITTLLIKRKDTFYNLVHLKLSCPFQPFNLDDLLDKRNFLKTLDLRFAKIEINPKALKRTKRRSLQSFTATRSEITSDVLRYLSFQCRDLNTLYLHRTKVFGKFNSTQGCHFIDMSYTRFNLLRFVSVPFIIKDNPINGHNINITLITRPVDDIPPKNDDSVETLPISFESSSFKVHYDWLYSLNSSMRPLPKAASKNAEEFFMNFEDNKELFLNTYVPNPRTEKINLNKWKYDPKCHNKTDWKLKFIYGYTRIKCGYVANFALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L0C8</accession>
    <name>A0A167L0C8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_172549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440992">
        <property type="protein sequence ID" value="OAD69298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287338.1">
        <property type="nucleotide sequence ID" value="XM_018436827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L0C8"/>
    <dbReference type="GeneID" id="28997733"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172549"/>
    <dbReference type="InParanoid" id="A0A167L0C8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="145" mass="16712" checksum="964BE6AFE3690C0A" modified="2016-07-06" version="1">MAIMLIYSISRSSSSSTSTSTSTSTGAYRILITMYKDICNEGGLILSKRVTCNISYNAKALGLEVQEIQNLQGEESIPDFVLFSEIADFDSQNRFQKNIYTKMSRDNLYNNSLYKYICKCECEYECEYEYEYECECVKRQKVICV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L8Z6</accession>
    <name>A0A167L8Z6_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_171887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287905.1">
        <property type="nucleotide sequence ID" value="XM_018436685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L8Z6"/>
    <dbReference type="GeneID" id="28997591"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171887"/>
    <dbReference type="InParanoid" id="A0A167L8Z6"/>
    <dbReference type="OrthoDB" id="2380640at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024368">
        <property type="entry name" value="Ecl1/2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12855">
        <property type="entry name" value="Ecl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="125" mass="13935" checksum="BE3435A778709CD4" modified="2016-07-06" version="1">MICDTNWCTYCDSAVSPFSDSLYCSEECLKKDALAHHPMLGYDFIDLRSFPRNNNQDGSRDAPFETRRRSTCSMSSQGIPGLISHSACVSANSSLGYSPPTYFNLKPQKNTLDTHRPVQSLFNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167L997</accession>
    <name>A0A167L997_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHYBLDRAFT_135526</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HRD1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD69887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287927.1">
        <property type="nucleotide sequence ID" value="XM_018429727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167L997"/>
    <dbReference type="FunCoup" id="A0A167L997">
        <property type="interactions" value="597"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167L997"/>
    <dbReference type="GeneID" id="28990633"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_135526"/>
    <dbReference type="InParanoid" id="A0A167L997"/>
    <dbReference type="OrthoDB" id="7759664at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16479">
        <property type="entry name" value="RING-H2_synoviolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058051">
        <property type="entry name" value="Znf_RING_synoviolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF184">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SYNOVIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="210"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="291"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAD69887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="363" mass="42349" checksum="24C5E89FD5D0A987" modified="2016-07-06" version="1">MRLAVYGGASFMLALGVVLSALHQNSNFYAACVYLSKSSSCVMVLLNLGLLFSIIMGKTLQSIFFGQLRAIEVEHLYERSWYAVTETCLAMTIFREEFDLQFVLVFATLLFLKIFHWLCQDRVEFMEQSPSHRMTFHVRMVNLMALLLLIDILLACHAINVTITKGPNMMIMFGFEYTILICIMTSIIGKYILNVVDMRSQEPWEGKSMYVFYLDLVTDFFKLITYIVFFIFLCFFYQLPLHIVRDVYVTFRSFIQKCRDLYRYRRATRNMNELYPDASAEDLLRTSDSTCIICREEMHAIVVDNNGHADAPGDIDQNLDQPKKLPCGHIFHFYCLRSWLERQQSCPTWLVTSITLTLIRNQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LB56</accession>
    <name>A0A167LB56_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_172053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440990">
        <property type="protein sequence ID" value="OAD70037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288077.1">
        <property type="nucleotide sequence ID" value="XM_018436723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LB56"/>
    <dbReference type="GeneID" id="28997629"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_172053"/>
    <dbReference type="InParanoid" id="A0A167LB56"/>
    <dbReference type="OrthoDB" id="10593356at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="127" mass="14668" checksum="F86B907DC6190979" modified="2016-07-06" version="1">MPVQRYTPIPEILTVHVANLKQAVDDYLPKYGAVTMVRKGADMENQQEEHLSKTSSSVKHAKRIFDQVIKAHHVCNRSGEKEIKEKLCQRGDFRFIQRSSKENQKSLILKHSKIHIVRAEYGMVNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LD35</accession>
    <name>A0A167LD35_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">DNA-directed RNA polymerase III subunit RPC3</fullName>
            <shortName evidence="9">RNA polymerase III subunit C3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_76185</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288225.1">
        <property type="nucleotide sequence ID" value="XM_018443129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LD35"/>
    <dbReference type="FunCoup" id="A0A167LD35">
        <property type="interactions" value="779"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167LD35"/>
    <dbReference type="GeneID" id="29004035"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_76185"/>
    <dbReference type="InParanoid" id="A0A167LD35"/>
    <dbReference type="OrthoDB" id="272392at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055207">
        <property type="entry name" value="POLR3C_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013197">
        <property type="entry name" value="RNA_pol_III_RPC82-rel_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008806">
        <property type="entry name" value="RNA_pol_III_Rpc82_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039748">
        <property type="entry name" value="RPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08221">
        <property type="entry name" value="HTH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05645">
        <property type="entry name" value="RNA_pol_Rpc82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22536">
        <property type="entry name" value="WHD_POLR3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase III subunit RPC82-related helix-turn-helix" evidence="11">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III Rpc82 C -terminal" evidence="10">
        <location>
            <begin position="143"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase III subunit RPC3 winged-helix" evidence="12">
        <location>
            <begin position="374"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD70185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="542" mass="62747" checksum="DA9F819976A396A6" modified="2016-07-06" version="1">MSQQARLCREIIEEEFGPFVAKVAHQILLKGRLTLPDIVRFTKLTPKQIRESLVVLIQHGLAFFTEAVEGQKEQTHYQVSAEQTLMRLRMPAIMQVAEERWEEIGVDICRLLFIHGRMKIGGVRDWVKGDSKRKDKMDQYIKAFTKMANEHYIIAVLPEHSRSAVDRYLEAEQKESEKYTITTAKEIQAIKKSALESVEAEYGMLENAGLKRKAIDAISSAHKRMAVEIEDMEVDEKIYFHINYERFNILFRNNSVMDYAIERINRTAGQIVKAFFEHGKNKIRSLHENDSPSATPMHIANIIPQDVIDQGDIVLQPDLINPGKKPSVQDIITGYITLLKIDSAGFVRSRDELGSSQYSINFLKLRENMKRKLLEGLVREKMGVATCRILRILIEKGKLDESQVQKLAMLPPKDTREKLALLNLRGFVEIQANRLDVNEVPRTADRAPGRSFHLWYVPLEKIYEELLVDVYRTVANLQQRRRQELKVRSRLLEKLNRQDVKENIDLLGEGDKAEITQMDKVLERIEISKKRLDQMIMILRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167LXM3</accession>
    <name>A0A167LXM3_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_126060</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="KV440986">
        <property type="protein sequence ID" value="OAD71299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289339.1">
        <property type="nucleotide sequence ID" value="XM_018429075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167LXM3"/>
    <dbReference type="FunCoup" id="A0A167LXM3">
        <property type="interactions" value="573"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167LXM3"/>
    <dbReference type="GeneID" id="28989981"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_126060"/>
    <dbReference type="InParanoid" id="A0A167LXM3"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="268"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD71299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="452" mass="51188" checksum="6D2095D07F541DEA" modified="2016-07-06" version="1">MDAFGKDEYQPLTHNGHDWAPGGLGLMIVDSLDTMLLMNLTEEYAQGREWVATKLSFDKNQDVNLFETTIRILGGLLSAYDLSNKDPIYLEKATDLGNRLMGAFKTESGVPYASVTLSTGLAYKYHVPSSTAEVTTIQLEFKYLSYLTGDPKYRLAAERVMQHMDKLVQQGDTTDGLVPILINPLDGTFATSEIRLGSRGDSYYEYLLKQYLQTSKTEPHYREMYDYAVDGIQKNLLARSYPNHLLYIGELLNGKPGNIHPKMDHLVCFMGGSYALGATEGVALADLPPLTGRNKRDLETGREITQTCYEMYSMTATGLASEIVYFNDDENTEPNGADMAIHFQDRHNLLRPEALESIFLMWRLTGEEKYREWGWKIFEAFEEHAKLPMGGYAALKDVTKVPATKENRMDTFFLAETLKYLYLLFSPDDVVPLDKYVLNTEAHPLPIFTPNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M3S9</accession>
    <name>A0A167M3S9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_170359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440985">
        <property type="protein sequence ID" value="OAD71699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289739.1">
        <property type="nucleotide sequence ID" value="XM_018436321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M3S9"/>
    <dbReference type="GeneID" id="28997227"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170359"/>
    <dbReference type="InParanoid" id="A0A167M3S9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD71699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="110" mass="13203" checksum="47D2709BB8B86B3D" modified="2016-07-06" version="1">MNLGYILFHYTVYKDPEKSYKQFKSLSHTVEKYSQNLLDRADNPIRKGIIAIIIFFRWSLLVIAGEKIALSRVVQWSRPNFGKANLNSTYKFLMVIIYKEFSWKYWMHML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167M5H8</accession>
    <name>A0A167M5H8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable quinone oxidoreductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NADPH:quinone reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHYBLDRAFT_146839</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD71859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018289899.1">
        <property type="nucleotide sequence ID" value="XM_018431736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167M5H8"/>
    <dbReference type="FunCoup" id="A0A167M5H8">
        <property type="interactions" value="449"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167M5H8"/>
    <dbReference type="GeneID" id="28992642"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_146839"/>
    <dbReference type="InParanoid" id="A0A167M5H8"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05286">
        <property type="entry name" value="QOR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000053">
        <property type="entry name" value="Quinone oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047618">
        <property type="entry name" value="QOR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF13">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="10"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD71859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="320" mass="34663" checksum="9FAF5CCB0C134F28" modified="2016-07-06" version="1">MNAVVVEKHGGPEVLQYKQVPIPKADQKNLVIRNHIIGVNYIDTYHRSGLYPLPTPLVVGKESAGEVVEVGPGVTNFKVGDRVVYLGGDTYAEYSKAEPISVVKLSDNVSYETAAASVLQGLTAWTMVRDGYPVKKGDYILVHAAAGGVGLLLCQMCKHLGAHVIGTVSSNEKAKIALENGAEFVINTNEENTVERVNEITGGLGCHAVLDGVGKATFSDSLEAVRRLGTVISFGNASGTVPPINIAILSKKNVKLMRPALYNYLGSREEVNKWFGELWELLEAGHIKIHIHKIYDLKDAKQAHLDIESRKTTGKLLLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MDM0</accession>
    <name>A0A167MDM0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_169675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440983">
        <property type="protein sequence ID" value="OAD72547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290587.1">
        <property type="nucleotide sequence ID" value="XM_018436131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MDM0"/>
    <dbReference type="GeneID" id="28997037"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169675"/>
    <dbReference type="InParanoid" id="A0A167MDM0"/>
    <dbReference type="OrthoDB" id="2253782at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="405" mass="46963" checksum="AF779EC71AA57A1F" modified="2016-07-06" version="1">MLPSELPIEILSQIAEHLSKKDKALCALACKRWKVPFQESFWKNISAQSIEELCEICTIPKDSLHENPYALVKSLAVGGKSTFTAWLECGIFQIFSSLTHLDVRCLHIQTVDVYDANRSDSFRSLKEMEQQKVISFISQFPNLEEVNIYSYDGQRILTFTTSDIDTIHNNLPHLKSVKGRFSLDDIDQDTIDNLQNTIPALSVTSLDLIITKKDCIWCRYLELIKLTRLQICGIISEETKGVSIDMPYTKTQKLIFDRVQFYSSTEHLNERTKINLILMSQLTEASQSDENEETAGVESSMSYICWLHRFKETENVNNFTQWYRELSDQDCQEILAYYHKSSYKKKNIGTQEVRKGFGRKTTKKFWEDDLGRGYVEWVCSPLVDNNDSLSRLKDSNFYNVFFWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167MXW0</accession>
    <name>A0A167MXW0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_167855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292484.1">
        <property type="nucleotide sequence ID" value="XM_018435733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167MXW0"/>
    <dbReference type="GeneID" id="28996639"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167855"/>
    <dbReference type="InParanoid" id="A0A167MXW0"/>
    <dbReference type="OrthoDB" id="2264429at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007890530" evidence="2">
        <location>
            <begin position="31"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD74444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="467" mass="53486" checksum="602FB09E7AE83106" modified="2016-07-06" version="1">MRVPLSYEHQIQLVLIASALIILLLPVNSAAPIETDLKENQDQSDIETYLLRHLSKAVIDALKVLKTVIFAYIAHVMTVRSDPSTTLLPNIYKRLSALAWPTGSVYESFGVIVKLRSSNKWFYPNGTSRDTCDPIIAYSSLPTLNSNNRISSTTPFIPSQREISPFDVNPGLESTRMNQYDNIEYLKNTLDKMGPKKAKRVKVCIFNGSLYIDTNTLLISKNGTNLRLKTADMTICGLGVNCTYQLPVHPSYVRYFSKSMIDELELSSYIQKRASFKTFIAFLQLAYTVYESAYSIRGVVEFQNTYEDLKAEEKEYSHFFATFFVRVFPGIPKKIFTDRECIAYDILCKVGIKQKDVYALANPSKTAEILNRVQYPDWWEAVVILGSTFIWIMLGFWPGFMTGTITEVLVLIWIFAGFLFLILRIFLFDPSYLIGWKLYFFLRFFCCCQASVLFLLPQSMVTFLELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167N947</accession>
    <name>A0A167N947_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_143631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293420.1">
        <property type="nucleotide sequence ID" value="XM_018431032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167N947"/>
    <dbReference type="GeneID" id="28991938"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143631"/>
    <dbReference type="InParanoid" id="A0A167N947"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="145" mass="16369" checksum="773516FF437A778E" modified="2016-07-06" version="1">MNSETVSETLRISCKYNYESQVISLLQAMHSEIISLKTGQDTIKLELNSTREELNSKIDYLQSQLDNRGFSEQETVPSATDIPCNSLIRAPIPNIWDITLKHVFKMMSEDLGIEVNNKEKATLRVCTKIICDELAVHPLVKDLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NBG9</accession>
    <name>A0A167NBG9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_166830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293639.1">
        <property type="nucleotide sequence ID" value="XM_018435503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NBG9"/>
    <dbReference type="GeneID" id="28996409"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_166830"/>
    <dbReference type="InParanoid" id="A0A167NBG9"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD75599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="193" mass="22953" checksum="E68AB982C7251A0D" modified="2016-07-06" version="1">MINNPKNYVCVFPRTKSAKSTQYIYIKIEVTRQNVLREINEVYIYELKKLVYKLNSDALVLWHNYKSDEVFDIFVGLDYRTSRNGSLPNRGPKYSILLCVMTICMHIVSTKIKMKLVHYKENNISIRKSMLLQRSWKTLEEYTHVLGFFELNNYEDRKKGNNVATDRESCLNSLLSIEIYKLVPREYFKAERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167NUH8</accession>
    <name>A0A167NUH8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_109147</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294676.1">
        <property type="nucleotide sequence ID" value="XM_018428095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167NUH8"/>
    <dbReference type="STRING" id="763407.A0A167NUH8"/>
    <dbReference type="GeneID" id="28989001"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_109147"/>
    <dbReference type="InParanoid" id="A0A167NUH8"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF77">
        <property type="entry name" value="SERINE THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="12"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD76636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="347" mass="39658" checksum="FDDE6BD3F0BC2D61" modified="2016-07-06" version="1">METKDGRKINNYLLREEIGRGAFGTVHLGIDTDTDKSYAIKEFSKSRLRRKERSDMLRQSGRPGMGAGKPSNPLDLVRGEMAILKKLNHPHVVKLFEVLDDPNDDSLYMVFEMAQKGVLMKVDVDQVAKPYSNDEARRYFREMILGIEYLHNNDIVHRDIKPDNLLLSSGGMLKIVDFGVSEMFKGNDDKLKKSAGSPAFMAPELCIAHHGEISGKAADIWSMGITLYCLIYGRPPFRTSSLVDLLDMIRDDPIHYEKSTDPDLLDLFYKLLERDPSKRITMLEMRNHPWVTNRGKLPMITEEENCRALVTEITEEEMANAIKSVANIFTVVSIQCRYKREKNKKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P0V2</accession>
    <name>A0A167P0V2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_142545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295071.1">
        <property type="nucleotide sequence ID" value="XM_018430830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P0V2"/>
    <dbReference type="GeneID" id="28991736"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_142545"/>
    <dbReference type="InParanoid" id="A0A167P0V2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD77031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="170" mass="19100" checksum="37F4EE85A4AC8BCC" modified="2016-07-06" version="1">MSHLPGVLFFWKDPERPIDMILLQSDQSKSFVLYVTILRADLQLSKSYSIHTTIIPTPSSIPMTPFNSTKRTPPNKKSRDVNLSSLACAMNNLSSPPIKADPSSTGRRPVLTSWKRTEWGGDRERWGVRLAMGLKNKREGKLNYPTPTTPTTPTTPPIHTTPTPIHPTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P297</accession>
    <name>A0A167P297_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_185948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD77108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295148.1">
        <property type="nucleotide sequence ID" value="XM_018439173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P297"/>
    <dbReference type="GeneID" id="29000079"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_185948"/>
    <dbReference type="InParanoid" id="A0A167P297"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD77108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="151" mass="16662" checksum="2DD07FD37CD438A7" modified="2016-07-06" version="1">MPSNAHYVESLPPSPTIETNIRPSMCPQCYHQIDSTQPPHTSFLCCVFWRSSELPWKCTECGYIQKQTQASGNNNIKAVDSGYDTPVKDESSPQYVPMHAPTPAWVARTGWTPQPDINTVINRGLCTSCDSYVKIEGGNCSQCGIPLAKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167P9J4</accession>
    <name>A0A167P9J4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynamin-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Scaffold protein Tuba</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_164436</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295568.1">
        <property type="nucleotide sequence ID" value="XM_018435002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167P9J4"/>
    <dbReference type="FunCoup" id="A0A167P9J4">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167P9J4"/>
    <dbReference type="GeneID" id="28995908"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_164436"/>
    <dbReference type="InParanoid" id="A0A167P9J4"/>
    <dbReference type="OrthoDB" id="10256089at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031991">
        <property type="term" value="P:regulation of actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF20">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="DH" evidence="11">
        <location>
            <begin position="378"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="937"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="137"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="229"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="264"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAD77528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1008" mass="113889" checksum="7D9E064FACE2C100" modified="2016-07-06" version="1">MGSPVHKPCIPKRPDPFSKALGISSNHDHNQDPNVQHPSQVSQLSIDRNQPHLALSTSIQQHPQCRPVVPVKPASLRLSAISPSRTNTTPSDPSPRTIYDISSIDQAHEIVGDLLDFSSIRAKFQSIEQPVKVPLTRQKASLSEPNPRMSRRTVAKTETSRRSVPDIHPPNAKLPPPVPAKRWGTRKTPDEESPRAISWTSSVSPVTVPRTGSFVAELSRRLEQAERMAEPVRQIKPASPHPTKPKFPNESHLAIPPPSTNTHRSTSLSTLRLPLPRSATGTSVNSMTSTSSNSSGTSRRAWPYGSAMASWLSGSSSSDDLQLSIPSGHVTNSSSRRSLFPNMILTASPPSYPSDPSDLPPVSPDLLDGPELTALPTKRARVVQEILETERTYATDMRLVKEIYYDKAFESHSPLNPLDVRHIFSNLLDILALESDFLPLLENACKNELDSDLQPTRIKTNENSIGKLFREMTSRLVQVYGDYCKRHEDALNRLQELEAKPAVYVFLSACKEDIQGRTMCWDLPSLLIKPVQRVLKYPLLLKELVNMTPTTHPDYEQLTIANKEIQGVADAINEIKRRKDIVEKIVREKKRNEMSMVHGFNKTLTRHAQRFRQTTGLSSEPTQDQSFDALYQKFESQQEIVRQWVKAIQEWGDHLKHTADTFHVFLLHLESFYNTWGGVRVKSMERVQEITRITHTLHMAISHEVDALVQGKMCGRVEAFLKVYESPGQVIHKRARKLLDYDRVRYMKNKGDIPDKVTQESADAYVSINAQLVDELPRFFLLTARYFGILVDEFATIQARLMTHTTHQWRAHAEKYFQLGDPQKMSYEAITQNYHKIMTEIVQPQIDDIQSIRYSPTVNCNLRQSTESVPASSRLSQSLYQDSQWLSEGQITPQPERAQNFQQKDKRISRDSQDSAVYVRAINRQSSLSSFLIEGSDPVFECVATSSLKSQGPEALSITKGDIIQVWLPTKDQISGDAATAEWWYGSLRTVEGEPMFGWVPSWYCQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PH19</accession>
    <name>A0A167PH19_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosome subunit biogenesis protein NIP7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHYBLDRAFT_108851</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with pre-ribosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NIP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD77898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018295938.1">
        <property type="nucleotide sequence ID" value="XM_018428073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PH19"/>
    <dbReference type="FunCoup" id="A0A167PH19">
        <property type="interactions" value="441"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167PH19"/>
    <dbReference type="GeneID" id="28988979"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_108851"/>
    <dbReference type="InParanoid" id="A0A167PH19"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042255">
        <property type="term" value="P:ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.220:FF:000001">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="8">
        <location>
            <begin position="95"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAD77898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="180" mass="20366" checksum="35DA79C902D4739C" modified="2016-07-06" version="1">MRPLTAEETTTLFEKLAKYIGANIKHLIDRPDETYCFRLHNNRVYYLSEAMMRIAASVGRDQLGSAGVCFGKFTKTGKFKLHITALDHLAQYAKHKIWIKPNGEMPFLYGNHVVKAHLGRITDDTPEHTGVVVYTMSDSPLGFGVTARSTVDMKKLAPTDIIMFHQADVGEYLREEDTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PIR5</accession>
    <name>A0A167PIR5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_141884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440974">
        <property type="protein sequence ID" value="OAD78024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296064.1">
        <property type="nucleotide sequence ID" value="XM_018430687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PIR5"/>
    <dbReference type="STRING" id="763407.A0A167PIR5"/>
    <dbReference type="GeneID" id="28991593"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141884"/>
    <dbReference type="InParanoid" id="A0A167PIR5"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF11">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007891187" description="Fungal lipase-type domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="2">
        <location>
            <begin position="164"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD78024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="355" mass="39788" checksum="63CDE060DB032B80" modified="2016-07-06" version="1">MKYFYFILSALSLVYISVVHARSSAIDDSYAPSADSGRFDIPDNIQGGDLDCETRETEQNLLLPFGRPTKGNGRNAGREPPAIREQLDSVDGESASEAEIENLTYYTYLVANAYCRNVVLNSDWNCPHCKGYVDDVSLIYTFKSEEYDMRGYILRDDNNKVINIVYRGSNSLKNFISDFQTDKIDYPPVRGTQVHRGFYNSYLDVADLVVPVAQQEIELHPDYSFVVTGHSLGAAVAILSALDLYQKDTRFGPDNMRIYTFGGPRVGDPAFAYYTIGTNIPLTRTVHRLDVVPHVPPQNMGFLHAGPEYWIQQDSGRVKVCNTQTEIGECSNSIVPYTTGDDHIKYFNIATGTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167PSV8</accession>
    <name>A0A167PSV8_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stc1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_62758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296518.1">
        <property type="nucleotide sequence ID" value="XM_018441011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167PSV8"/>
    <dbReference type="STRING" id="763407.A0A167PSV8"/>
    <dbReference type="GeneID" id="29001917"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_62758"/>
    <dbReference type="InParanoid" id="A0A167PSV8"/>
    <dbReference type="OrthoDB" id="3514033at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024630">
        <property type="entry name" value="Stc1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12898">
        <property type="entry name" value="Stc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stc1" evidence="2">
        <location>
            <begin position="36"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD78478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="145" mass="16179" checksum="DED9C19345D656D0" modified="2016-07-06" version="1">MSRQGPAGKFRIQPAFQDGYGTQGANDQSPKLKSLRCVFCSIDKPLDAFSQTQIQKATFNPYAPPSYNKGTKAKQISCKQCTASVNSTLTCMTCTKTKPLESFAKVQRKHAEKARCLKCMKKREEEDLDDSEYDSDDDSDPYGPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q464</accession>
    <name>A0A167Q464_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeodomain-like DNA binding domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_141092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD79038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297078.1">
        <property type="nucleotide sequence ID" value="XM_018430525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q464"/>
    <dbReference type="GeneID" id="28991431"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_141092"/>
    <dbReference type="InParanoid" id="A0A167Q464"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="41644" checksum="3E9C8FE4463EF5A7" modified="2016-07-06" version="1">MPSNSSRKTDCKGKEKASASISTSANRVLAGCVGPQEIAPSFSSATIQDQQYMEIVEMFNKVNNSINSVKDDIAAVNSNMTAFKNRMGIVVDTSGKTHMAFADFATAYANDQTRMASLEPSLMPSYVPQTSLSDAEVSVIISEIFVEKLWDWKFESDDPALVAENESKKKWNLNEKINHRNNVAVIKYLKSYISAQTRLAGTHPQVISDKIKNRYKHSHRTFHESPEQKAKKNSKGRANSRTLQMSIRRKSTYMDNWVAIDAAIGYKTGNPVEKAYLKLFQKDAMSDGESDIEIVDNLPRRCLHVPRPTWRSEEFNRLLTMVDDIDRTYHVSNADMGTKLRMNRYPATLLPCSVPATLSQSLPCWAINDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167Q9H5</accession>
    <name>A0A167Q9H5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Helix-loop-helix DNA-binding domain-containing transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHYBLDRAFT_139351</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297357.1">
        <property type="nucleotide sequence ID" value="XM_018430203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167Q9H5"/>
    <dbReference type="STRING" id="763407.A0A167Q9H5"/>
    <dbReference type="GeneID" id="28991109"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_139351"/>
    <dbReference type="InParanoid" id="A0A167Q9H5"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="75"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAD79317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="162" mass="18340" checksum="ED95397964A61177" modified="2016-07-06" version="1">MPNIYPPAFAPYPPIIGNNNSNNSWHSSSASSSPTSPGSSRKRPSPEDCSVQDIKPRPRERRHRKAPHELLTDAEKKANHIASEQKRRQNIRLGFDQLIDSVPSLHHGNRSEALILQKSVEHIQHLISIKNDLKNQVRDLQSVLGDPNYEEDSSEDELSYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QCI9</accession>
    <name>A0A167QCI9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_162550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297524.1">
        <property type="nucleotide sequence ID" value="XM_018434649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QCI9"/>
    <dbReference type="GeneID" id="28995555"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_162550"/>
    <dbReference type="InParanoid" id="A0A167QCI9"/>
    <dbReference type="OrthoDB" id="3247418at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD79484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="595" mass="67875" checksum="F10EA85FB5B3F3E4" modified="2016-07-06" version="1">MTDKRTAKRHAQNDNDRKIDKIINVLTAKVNTSETDMDVDQIEEYVEDDNHSVGAPSPEQYVHIYLPLLVEESLFGTEEYTSEYESEYESSDEIEPEEQDREEEQESTANLPENPWHEVIAIFTVMFISTFIMDDSAVILITFINTILEHYGEDFRLPISILGLKKMTGYNDLMNRVSNYVKSRQQDLLWKQALQTQYKKCNDSQTYCGISECIYCLTSVGVTIMTSNHKSALGLPTKLAPYRSDTVYPAMIATTLSQYEYVLICDKSNIRVSGSPHLHQLMYFEPVHATVIDPMHNLFLGMAKCMMDNWIACDLLDSNDFAEMQKEADSMTLPMGALTKPAITEEEIDKAHVSLEKFCCSCETMYKLDLLLPNMHLHLHLKESIQDFGPICSFWLFSFECFNGVLKGFQTNQKSGFKKTYMKKFVEDSSKGDFYHTHLSTINNPSYISVFNKLTDSITGTIPSGNHQNLLSFFHLSSFLESTTNPEQQTFGNEPLPPSALPLALKEATTMRKAEYGCLLKLYKIEYDDDTLCSAKTMLRHRIFVNDRIQKIASINLLRQVYKGGEGLIMRGSYIQAKYMGTNNNSKGIYAGYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QTA5</accession>
    <name>A0A167QTA5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_140245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298281.1">
        <property type="nucleotide sequence ID" value="XM_018430362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QTA5"/>
    <dbReference type="STRING" id="763407.A0A167QTA5"/>
    <dbReference type="GeneID" id="28991268"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_140245"/>
    <dbReference type="InParanoid" id="A0A167QTA5"/>
    <dbReference type="OrthoDB" id="2430203at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD80241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20860" checksum="4BB35E49A97C2129" modified="2016-07-06" version="1">MTISKSICIDTTYGISARSMEVLYSIVTCHPETGKTEINAITVVLPQTAIHFCNFHVLRAWQQNLDSKVKSDVLYISEQLGKYKQKLKNGLKDILVESDEETFLEKIDYFTEHILSQDDFEFFYDEEVERIHVNNRRMRPVENKLSQHSYAASQIQEDILSTMIISPSGEIRNSMNDSDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167QZQ9</accession>
    <name>A0A167QZQ9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHYBLDRAFT_176512</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Lipid-anchor</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the small GTPase superfamily. Rheb family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298564.1">
        <property type="nucleotide sequence ID" value="XM_018437794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167QZQ9"/>
    <dbReference type="FunCoup" id="A0A167QZQ9">
        <property type="interactions" value="313"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167QZQ9"/>
    <dbReference type="GeneID" id="28998700"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_176512"/>
    <dbReference type="InParanoid" id="A0A167QZQ9"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04137">
        <property type="entry name" value="RheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000273">
        <property type="entry name" value="GTP-binding protein Rheb homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAD80524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="185" mass="20691" checksum="2C045D7E8079A75A" modified="2016-07-06" version="1" fragment="single">MSNQAKARRIAVLGSRAVGKSSLVIQFCENHFVDSYYPTIENTFTKTIKYRGHEYVVEIMDTAGQDEYSILSSHHASSVNGYVLVYSIASRSSFDMIKIIRDKILDFTGLETVPCIIVGNKSDLNIQRQVTLEEGKELAQQWACPHIETSAKHNENVAKIFDMLIASIEKANNPPSEEKNACSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167R3X1</accession>
    <name>A0A167R3X1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA-processing protein EFG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">rRNA-processing protein efg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_161431</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EFG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD80789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298829.1">
        <property type="nucleotide sequence ID" value="XM_018434400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167R3X1"/>
    <dbReference type="FunCoup" id="A0A167R3X1">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167R3X1"/>
    <dbReference type="GeneID" id="28995306"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_161431"/>
    <dbReference type="InParanoid" id="A0A167R3X1"/>
    <dbReference type="OrthoDB" id="47732at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019310">
        <property type="entry name" value="Efg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050786">
        <property type="entry name" value="EFG1_rRNA-proc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10153">
        <property type="entry name" value="Efg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="201"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="98"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD80789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="237" mass="27601" checksum="F8AD0BAA41870CC1" modified="2016-07-06" version="1">MNQTKQPTQGSNTTQNEPRQKYGKQKTNKGKSLDSMSKIKKRIRDVSRTLKKGARTAKIRVESERRIRALEYELGEKTIDAQEQKNATAYHQVKHIERKKAERKLAQATSALEAASEEDKEEAEKLVEERKIDLLYTKHFPKSLPYVSIISKSDEKKQNTTREEVREKIRESIKNGEDFTDMQKFYRDKCRAWLEKSKKIPAAKPVDVDEEAPVDDKMDEDEDSDAEKDSKKDDFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A167REW0</accession>
    <name>A0A167REW0_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="4">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHYBLDRAFT_184627</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="4"/>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299528.1">
        <property type="nucleotide sequence ID" value="XM_018438962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A167REW0"/>
    <dbReference type="FunCoup" id="A0A167REW0">
        <property type="interactions" value="465"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A167REW0"/>
    <dbReference type="GeneID" id="28999868"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_184627"/>
    <dbReference type="InParanoid" id="A0A167REW0"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000276">
        <property type="entry name" value="Acyl-protein thioesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="15">
        <location>
            <begin position="6"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAD81488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="225" mass="24431" checksum="E446BCC2B30F2787" modified="2016-07-06" version="1">MSALSSVIINASTKQTATVVWMHGLGDSGAGWSFLAEQLSGLFPYVKWILPNAPSIPVTLNGGMSMPAWFDIKELGRKNATSEDRDGMLQSVTTINKILRDEVDKGIPANRIVLGGFSQGSVMSLLAGLTSEYKLAAIIGCSGWLPMPDRIQNMASDANKKTPILMCHGDADPVVNYTFGKESAERLQQLKYDVEFKTYHNLGHSAAPQELLDISSFLKKNIPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N5Y1</accession>
    <name>A0A162N5Y1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_175411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441005">
        <property type="protein sequence ID" value="OAD66114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284154.1">
        <property type="nucleotide sequence ID" value="XM_018437483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N5Y1"/>
    <dbReference type="GeneID" id="28998389"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175411"/>
    <dbReference type="InParanoid" id="A0A162N5Y1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="170" mass="20006" checksum="74B5B2DBE0FF39BD" modified="2016-07-06" version="1">MIGYPRKVISGARRLSPLYQYIRIKFERTFLLEVDITMRFECRLSARIPVPYSMDLTLTRVHNACYIIMVHLNAKEPEEYLNRVAFFNIVWILVASIAYKYSHTFADKMVLVLVFDSRIELSQIYKICIFSFLYSHQVFVFLLVILALLLCFLFWFAQGTNALLTLKAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162N6P2</accession>
    <name>A0A162N6P2_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_175327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441004">
        <property type="protein sequence ID" value="OAD66274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284314.1">
        <property type="nucleotide sequence ID" value="XM_018437469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162N6P2"/>
    <dbReference type="GeneID" id="28998375"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175327"/>
    <dbReference type="InParanoid" id="A0A162N6P2"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="104" mass="12033" checksum="CA4549E9E7AD93A7" modified="2016-07-06" version="1">MCQKINELFTIEYPVTKMSSLDESLLIFFLVFLFLFLAQDYTKSGKGCMNMSVFDLHANSLDTPIFAKQRNEIPTVSKKDKEGSLHPWLIYNASHVALQDIWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NCZ5</accession>
    <name>A0A162NCZ5_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_65785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291228.1">
        <property type="nucleotide sequence ID" value="XM_018441533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NCZ5"/>
    <dbReference type="STRING" id="763407.A0A162NCZ5"/>
    <dbReference type="GeneID" id="29002439"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_65785"/>
    <dbReference type="InParanoid" id="A0A162NCZ5"/>
    <dbReference type="OrthoDB" id="79603at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="852" mass="95585" checksum="E58160EF5A877D4E" modified="2016-07-06" version="1">MIILSEENAADHDLLTEINPNHRAKESTVIHSTHPQKPNLPLGKAMHLLLNVKPQVFQLAVQKLNKNPSETSTESPVASALLSLEDHISIGLQRFSGVAEPALSPFLKRSTITAKNESDSAMRLARFLLLESRHRLVFCSLLENELKSTDRRSQLATVLLLDSVVQTWPDIDTVSDINPGLIYSIQVVADMSSNLTRVASASGSQPTLLACTAWDLVWTCSRYVAATLTSSLDQTKSSGSTQLPKIVLIESTFMIDKKKKDTMDTLWKYNESLVSTIRMWHTTMYFTQHLAWHQVLLFLSKAHTLILREDPDSVLVQMAKTWVLMTSALNTKNILSVKPLSQKKKAAILSLKKSGVEAHIEDYAKMVSLVAVQKGLWKNKLGIQTNPVPFSDEEKEEEKQIKAMVTNVYPSKINHIPLNEPFDGLGNEIAACLFLVMPHLANHTKLTAGALRILLSLEWDLEGLINMVDYESIIHHLKCIVYQQPEEALLYLTKGIDDSQALKSRFIKSVIESVIDGATQTNISEISQPLMNTLLMFTATTHVACELLIKCMAFLYLPELIARLMKMAYTLDPRQNQVSKGLIAKALLIDKWAGESILLYVDMIRQGENTRDFKYRKSFSTIFPGSHFTWRSTPADIEPTQAHILQENSANKLEDSDTDKYVMEFISVLGLWGEKAAPWALEAGLKQMVHKTCGSPLDQTNVLVWKTLSFAILGHRSLVWVVMQECSGVMKLQRRWIDDLQNDATTDDLFEKKLYAILTPMIILQALHPTVYECVNLNRQTAEEMKTHLVRCGNNLDNFKVSDDDDSKHSQLCAELLDALSIRLKLTPGLSAIENLSKMLTTKIFGKVSSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NEN7</accession>
    <name>A0A162NEN7_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_168046</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440980">
        <property type="protein sequence ID" value="OAD73608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291648.1">
        <property type="nucleotide sequence ID" value="XM_018435785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NEN7"/>
    <dbReference type="GeneID" id="28996691"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_168046"/>
    <dbReference type="InParanoid" id="A0A162NEN7"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008318">
        <property type="term" value="F:protein prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF3">
        <property type="entry name" value="PROTEIN PRENYLTRANSFERASE ALPHA SUBUNIT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD73608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="353" mass="41078" checksum="FE3575B390C9D2D3" modified="2016-07-06" version="1">MHHNSDEIGLLHIQPNLSDLPSESAAFYPLVVVESKLGISFQHLTALLSEAHKRYVLVRDAKGAADLAELEQVSRVLILIKPDHYTAMNTRKQLITSGQISIENELLLLELMFTIPKHSKSSIAWHHRQWIYKLKHSRNDPQSRLIDHINIEHELQLCDRTITLYPKGYYTWNYRHWLLSTMESDHHFVQKEYHHSRSRVEVNVSDHSCLQHLELALFAIVKDSPLKISILEDHLRWLDGVIISYPGHEALWYHRRYCLDILLCDMKDSIYYSQKHYEFIEDIAKGDPSPLAIDTNRSSLLRQVELALHFGVWLCLKEKDTGNVNIGRARSYLNRLESTPAISEIHRLFNDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162NLW5</accession>
    <name>A0A162NLW5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_111068</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293458.1">
        <property type="nucleotide sequence ID" value="XM_018428193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162NLW5"/>
    <dbReference type="STRING" id="763407.A0A162NLW5"/>
    <dbReference type="GeneID" id="28989099"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_111068"/>
    <dbReference type="InParanoid" id="A0A162NLW5"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD75418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="88" mass="10070" checksum="D375443BFFE11322" modified="2016-07-06" version="1" fragment="single">MVDYTNLYIKNLDLRINSRGLFDYFAPYGRIISARVMTNKEKKASKGFGFVSFGRAEDAYRALQEMNGKHIISKPIIVAFHAPKKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PML8</accession>
    <name>A0A162PML8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_171744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440989">
        <property type="protein sequence ID" value="OAD70366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288406.1">
        <property type="nucleotide sequence ID" value="XM_018436655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PML8"/>
    <dbReference type="GeneID" id="28997561"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_171744"/>
    <dbReference type="InParanoid" id="A0A162PML8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="105" mass="12132" checksum="9825460EDE68F758" modified="2016-07-06" version="1">MNTDEKQQSPRPQPCAGMSLSQMVKLTSWHVVNSNTLTFEYRNASIIVMVLMIDTCVQAFDLDVTEYFPIYRYCIIPNLSAAYLLNPIIEIIENYYNLSLFNLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162PSC1</accession>
    <name>A0A162PSC1_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_143778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440977">
        <property type="protein sequence ID" value="OAD75527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018293567.1">
        <property type="nucleotide sequence ID" value="XM_018431066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162PSC1"/>
    <dbReference type="STRING" id="763407.A0A162PSC1"/>
    <dbReference type="GeneID" id="28991972"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_143778"/>
    <dbReference type="InParanoid" id="A0A162PSC1"/>
    <dbReference type="OrthoDB" id="2379842at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22744">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="883"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD75527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1010" mass="115877" checksum="49B27591CAD90639" modified="2016-07-06" version="1">MNKVQYGLPCHHTLPVERDLQISDLPDRWVIDARKEDKAWNQPNMQVPVIEKPKEWMSEIIKLKALFHSCEGSQQVFDLLKKVKKAVNDFDSKNGHSPIKLQAPENVKYPGRRKGSSRPKYLPKDFGHPMWRKTSVLAGTMVEKSLSGLNVIRKQKKNIKKIKKEPLDSVDATKNKTKQVKQEPLDLVDAPQRNGFERPATALEDYQYDNRTSVGKRVKFQPGFPVSHEIINDVKGGFSPTADGWCGFWVLAHLIYKDQNKFSLVKRDMLAALPKYKTLYTNTFGTDTSQLEKIIQHGSQLDYSNTSNTNTNTNTNFIPVCSDASMWFNTSDCAQLAADTYTRPVCVYSDSPNTPSTTSLPFALPNNKTKQQQLLIFNPVNSNHWTTVDLSLNDITFDPRTSTIYRFMPTYENETEEFVFEAEEDNKLKREVPVGALIDPNLIKVTQYIKCDHSGTKAESLKKQAVENNELPVVKSRNTTGNSIKVGCLTALIVKFFNGGKVTVVYNWRHNNHNTLEISDISCSRLSEEARIWINEHVEKNLDWKAIKGLLRLEDVKLEEMENSMSMTSIPSAMMIQYKDIHNAIVARINNSARKHYKDEISTERWIAFLQEKGYQTMFDTYNSVGPLLVSWVSPWQKKFLENAEEWYLDSIHKTCKSFLDNKDCYLISVVVYNPVTNKGVPVAFFVISIECSYIIARWLNWLKDTNSLKVKQIMIDCSSIEQKAIRDTFGPSVQILLCHWHIKRAWESHVKKVTIPNTHLETKNVRANIRAALNLIMHSNNEADYNAHWQKFRLDYGMQFSVLISYMEDALAERDYHQDTLETYFGIKSIRLSVTDSERKRKASVIAIKRANGLVEEVELQKLQACKMYSCKSFGEGCELVYFIKFTTHLHDCSCPDSARLCKHIFLVSRVFDLPVTVRRNVVLDSAALFGLGENDGNIISEDNIALLENQMSKDEQKANLLLMNESLERIWKQVYISSKTFEQKEVLLDLMKKVNSVVNPTNELRKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162T855</accession>
    <name>A0A162T855_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_152108</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441000">
        <property type="protein sequence ID" value="OAD66842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284882.1">
        <property type="nucleotide sequence ID" value="XM_018432840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162T855"/>
    <dbReference type="STRING" id="763407.A0A162T855"/>
    <dbReference type="GeneID" id="28993746"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_152108"/>
    <dbReference type="InParanoid" id="A0A162T855"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD66842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="285" mass="31745" checksum="A3A0DFB520FED0EA" modified="2016-07-06" version="1">MQIKDKVVLVYGGTSGIGKELVCKLLKLGAYVVFTGRNQKNGDDLKEELIKEISSKDEESDDSRVLYHKCDITDWPSHILIYSEVKEKLGKSIDIVIVVAGMMDSSSIIDDSEQDGIYRTIEVNLTGAAKANRVAIQHFLKEKKAGCVINTSSIFGLCAAPLGPLYAASKHGIIGLTKSYGNLFRSTDIRVNCVAPHFVETPMLAYGSKTVVDKFGTITMDNCIDAYLRLIEDDTLNGDILTISTEKSYVEKRYGDEIQERLDRVCKKRREGELDKIRDKFGYPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TDR0</accession>
    <name>A0A162TDR0_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_160647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441004">
        <property type="protein sequence ID" value="OAD66313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284353.1">
        <property type="nucleotide sequence ID" value="XM_018434221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TDR0"/>
    <dbReference type="GeneID" id="28995127"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_160647"/>
    <dbReference type="InParanoid" id="A0A162TDR0"/>
    <dbReference type="OrthoDB" id="2281978at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD66313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="201" mass="22697" checksum="4609DB62CFA89EB6" modified="2016-07-06" version="1">MDLLIQREHDKAELLRKPKRINPSTVQVEGMLAKLPEQGIHNINFQNPNIRIAPPLPRVPMGDFNHSTNNLSSSQQYIQGRSIGPVVNHHQHQHQHHNQQHNSEHQKGQGHRMKNTDARRRAEMLRNEVSSIPPRPLSSMSTPSNQQPMMGQYMPMVVNPMQMPLQVQNPMGMVSSRSLGNSSRPLSMMGPTSGAWGSTMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TEY7</accession>
    <name>A0A162TEY7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHYBLDRAFT_175141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441002">
        <property type="protein sequence ID" value="OAD66593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018284633.1">
        <property type="nucleotide sequence ID" value="XM_018437422.1"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162TEY7"/>
    <dbReference type="GeneID" id="28998328"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_175141"/>
    <dbReference type="InParanoid" id="A0A162TEY7"/>
    <dbReference type="OrthoDB" id="411871at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="672"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="362"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAD66593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1371" mass="152868" checksum="777731F01E24AC32" modified="2016-07-06" version="1">MATLNSVGACRSGFSLLLSSRLYKTFVRPKFEYGLAISTLLKQDIKVLESIQDKCLRMIVGGHATSSTIVLKHICNLPSMKFRADALMAKFCIRSRFLPAQCLLSLLHRHHTVYSSLVSLGKTHLLSNLPPTLKLRSPSAVKNHFESIREAGFATFLQSNTQVLIQACRPVLGVDPILFLPASRVERSRLIRWRMGWLPGKPKECPCGSDHTSRRHLLDCPLVPMALFEQLPQPDQDQIHRIDFAITSLPLSSQEPRPAYWIPLLTILWHIDVICNPDGDYSHETEHVYPSINIFTQNDPSITKNVPPIAKSSAVLVLGIPAVSKKISAQSDNITPSAFSIPMANLQIGNMQGLPTELTSFLTTLQAKIMNVQNRTDQLERLAAENARLTTELDHARTTIANLQKQLGSQSAPEKNFSEISLSNPAGAVGAPDKNKEPGLEASTWATKASVSLSVTAPKMSTVPSARRIAASVRMFALPSGPSGYEYVYIPRSRRLKHKEVRSSLRTLGVDSSRLLDINFPARGVIGILVHVQYADTFKAKLTTASVEILDAFDPLDPDNVADPKYASLSTHELANTAAMLHHDRCLQALQFLRPHIAIPVGHFFCEEGWISEDEIPTRTTLTNATGGSLFKPGTYRGSMGVSVLISPHCPYAVTQIPMPSKYALAVKIGSLRIVCLYLPPNMPTHDVLHVLSSIPLTHDTILCGDFNARLGSVTGDYASNCRGLALCSWIEERSLSVVNADLAPCIPTYISFRNNYEISSIIDLFITNMPLINPSLHIATDLSLGSDHRLLSLSFTYDLQHSTNMPPPLRKTWNLSRLNEPDVHALYAHTFNQNSTSLLSTLQDIVQNPPLTRPNIDAITDEFNLLIYDSLNSSIGHRPSRPNHWKSFWNVALQTAADRRNQCYKKWRLAIGIDKVVWWTKHKHAQAEFRSQVQQAKRQSWHVFCQSMERDFSKATSKIKQLKRRRQPQHTFQHDDGPAVAAATMCDYLATVYSGHILPATRPPAPMTTCNSVPFASDDSPFTSPIVEEFMQFMPNRKAPGPDHIRAEMLKPIKTHFAGNGHMFQSIATHRRSGTLATMATLNSVGACRSGFSLLLSSRLYKTFVRPKFEYGLAISTLLKQDIKVLESIQDKCLRMIVGGHATSSTIVLKHICNLPSMKFRADALMAKFCIRSRFLPAQCLLSLLHRHHTVYSSLVSLGKTHLLSNLPPTLKLRSPSAVKNHFESIREAGFATFLQSNTQVLIQACRPVLGVDPILFLPASRVERSRLIRWRMGWLPGKPKECPCGSDHTSRRHLLDCPLVPMALFEQLPQPDQDQIHRIDFAITSLPLSSQEPRPAYWIPLLTILWHIDVICNPDGDYSHETEHGALWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TI72</accession>
    <name>A0A162TI72_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_63303</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV440994">
        <property type="protein sequence ID" value="OAD68792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018286832.1">
        <property type="nucleotide sequence ID" value="XM_018441102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TI72"/>
    <dbReference type="GeneID" id="29002008"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_63303"/>
    <dbReference type="InParanoid" id="A0A162TI72"/>
    <dbReference type="OrthoDB" id="7697726at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="47"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD68792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="101" mass="11406" checksum="26F432BAFC274336" modified="2016-07-06" version="1">MNPVFNNTAERQQVDISIQMMVALKCLEIYGTGVTAGSIAQTIGQQCRTGMTQENVDFNTVHSNICVSVEHCIRILKERFQSLKGLKTVIHTKKDIRKMCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TRF4</accession>
    <name>A0A162TRF4_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_115246</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440988">
        <property type="protein sequence ID" value="OAD70472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288512.1">
        <property type="nucleotide sequence ID" value="XM_018428448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TRF4"/>
    <dbReference type="STRING" id="763407.A0A162TRF4"/>
    <dbReference type="GeneID" id="28989354"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_115246"/>
    <dbReference type="InParanoid" id="A0A162TRF4"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="3">
        <location>
            <begin position="13"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD70472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="133" mass="15299" checksum="B868D3AF1BDC27ED" modified="2016-07-06" version="1" fragment="single">MSAATIPDLMQFNPHMVAYQLTLIDSAIFRAIPQTALLSHSPKSPHPCIVASTDFFNYFTRAIEHSILLPQEASRRAELVNRWIKIASYCLKLLNFQTLKAIVSALHSPPVSRLRRTWECIPKKRMQRLDFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162TT77</accession>
    <name>A0A162TT77_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_149389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440991">
        <property type="protein sequence ID" value="OAD69603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018287643.1">
        <property type="nucleotide sequence ID" value="XM_018432267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162TT77"/>
    <dbReference type="GeneID" id="28993173"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_149389"/>
    <dbReference type="InParanoid" id="A0A162TT77"/>
    <dbReference type="OrthoDB" id="5562028at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD69603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="119" mass="13340" checksum="F093BA713709C2AF" modified="2016-07-06" version="1">MTCRHLIDISSSQADPLQSRDVQERIDKYRALLDQMDSQPVSSTRMGGPKKEIYMSDHISPVDILAAAKPNEGMTETQVDWLYQTMDTIQDSLQQIQVSPAGEMVVRLTMPGSTPIRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U1X8</accession>
    <name>A0A162U1X8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_159000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290862.1">
        <property type="nucleotide sequence ID" value="XM_018433897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U1X8"/>
    <dbReference type="GeneID" id="28994803"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_159000"/>
    <dbReference type="InParanoid" id="A0A162U1X8"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD72822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="210" mass="24159" checksum="A49413AEBD6FB4A5" modified="2016-07-06" version="1">MHNYTEGENIFEVDCLNTIGPPDNELDYASDDSQSREKDFSEDSSVQNESDSKILLSGVLSTRNIPDSFSTEDEDEDEYTQQIIHDSEESMSDSYSPIEYMDDPVGDQPSFKKRYIEDQNTRPKRRRVIPNSQEDESEYSVMLSVTNAMNDTSLYEGMQDILGVRERRHRKVIPNSQPDIEPGDTEDQGLYESRIRGAFLKKFIDDDQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U3C7</accession>
    <name>A0A162U3C7_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHYBLDRAFT_79253</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440984">
        <property type="protein sequence ID" value="OAD72043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290083.1">
        <property type="nucleotide sequence ID" value="XM_018443447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U3C7"/>
    <dbReference type="STRING" id="763407.A0A162U3C7"/>
    <dbReference type="GeneID" id="29004352"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_79253"/>
    <dbReference type="InParanoid" id="A0A162U3C7"/>
    <dbReference type="OrthoDB" id="27140at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000038">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000031">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF337">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="142"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="539"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="593"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="908"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="613"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="662"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="672"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="695"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="936"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="958"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAD72043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="1029" mass="115660" checksum="ECD5B34602B94747" modified="2016-07-06" version="1">MRLVIFELRALQMCLAVKYKISHIGLEMPSADQSCDGQGLTLQAWDRIFSDPNLSVNSLRHRAVVGNVCQQGLRSVCWKQETNNFLHQIFLDYFPSLEVSSWSVIQRERRQYYADLRQQHIDGPTEKMTNKTDSQEDLTDNNPLALNESNPWQQFFADSEIRKIIRQDVDRTFPDVEYFRSEETQQRMTDILFIYCKINHDVSYRQGMHELLAPLYWIIDKDSIDLSENGDDLTSVSEPATKIMMQVLNSTYVEHDAYLLFERMMKYAKPWYEFNDDVPSRPGSRSKNVPLNPIVIACRRIQHEYLQAIDPPLYKHLESFGIEPQLYGIRWLRLLFGREFDINDLLKLWDAIFAQDPTLKIAEYICLAILLRVRDKLINHEYAECLTLLMRPSHLSGPASLVEQAKYLQENLSEDAALHILRQNDVRAGKEPRDSLWDGVRVVKADTNSRIAPNRLDQRRSQGANLDGFSSLTRGVMKSPHVREINKAIAGVMGTVQKNVNIIGDNMLGRSVSEVQSPTSRRRQTVPSEFPAGIDRLAATGSFHTHDSQNTSPENRRRKESDELARLQATNRQMADLMAKCIDLMEKELFSNSPEQVISKETTDETSEDVDQNNNNNNNNSSNSNSNNTSNSNSIIISGGSGDSLQEEDKSTNNDIVPKDLIQQDKEAREEGEGEGEGEGEGEDILSKDNEDLSSSRYSQKSKASSKASTSSSVSSKPDEVSLTMALAGLKHIRDVLSGKQIQFDPSAVSLLGKRNDQSSPDWRWDLVEHEEALEDKSQTPLVNNNSIIAPTTSYSSYSSSSYTSPSYSNTAIATATSTSTSTSTAVNSTTTAQSYSQPQAYLQTKPLPPINMTMPDIKALPPVNYIPTNPPPPKPQVVYRIEDLLSDPALQPVLPRSFQNPKFQWILQGDSNSNKDNDGDNNNENENENNKSKSKNSTNNSNNTPSSPKPDFIRAMSSPLSSSSLSLSSPSASDLFNLTVDSTPKTPKKRSSFTFSRTVEATSISAHTMDPLDAKNVDKRKAYDYDMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162U3Q9</accession>
    <name>A0A162U3Q9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_181465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440981">
        <property type="protein sequence ID" value="OAD73212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291252.1">
        <property type="nucleotide sequence ID" value="XM_018438473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162U3Q9"/>
    <dbReference type="STRING" id="763407.A0A162U3Q9"/>
    <dbReference type="GeneID" id="28999379"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_181465"/>
    <dbReference type="InParanoid" id="A0A162U3Q9"/>
    <dbReference type="OrthoDB" id="6021263at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024388">
        <property type="entry name" value="Ribosomal_mL58"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12824">
        <property type="entry name" value="MRP-L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD73212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="149" mass="17048" checksum="A3FABCFC131A1A3D" modified="2016-07-06" version="1">MFSRSFGLVRPFVSARTYATKSKTTNLKMTSRLPIQECQLADGSLFVTRQPPVSPAVQSTAPVLKKAATETKVLSESEKEEMRQLRAQDPARWTRKRLAEKFGCSEIFVGINAPTTVKRAVAAEQEPTKEYGYRRQLIKKNRERRKELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UAQ5</accession>
    <name>A0A162UAQ5_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_144193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292872.1">
        <property type="nucleotide sequence ID" value="XM_018431166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UAQ5"/>
    <dbReference type="GeneID" id="28992072"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144193"/>
    <dbReference type="InParanoid" id="A0A162UAQ5"/>
    <dbReference type="OrthoDB" id="2288126at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13290" checksum="811D0CBD5D1931B3" modified="2016-07-06" version="1">MPSTVSSPLCTICQVSIKTQEHFLLACSLKSAVWTGIWLEFFGTIPLPSVLSNTFQFFAFPPTLNPAIPASSVFGLTILAIWDHHWSFHFNSVPFLPSAVLHTARKSISRLCSELELDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UG29</accession>
    <name>A0A162UG29_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHYBLDRAFT_167269</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KV440978">
        <property type="protein sequence ID" value="OAD74933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292973.1">
        <property type="nucleotide sequence ID" value="XM_018435615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UG29"/>
    <dbReference type="FunCoup" id="A0A162UG29">
        <property type="interactions" value="495"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162UG29"/>
    <dbReference type="GeneID" id="28996521"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167269"/>
    <dbReference type="InParanoid" id="A0A162UG29"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14127">
        <property type="entry name" value="STKc_CK1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000160">
        <property type="entry name" value="Casein kinase I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="25"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAD74933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="398" mass="44885" checksum="B6E5AEA8F384FAA6" modified="2016-07-06" version="1">MAGNSQPSAPATNPSSSHNVVGVHYRVGRKIGEGSFGIIYEGTNLLNNQQVAIKFEPRKSDAPQLRDEYRTYKIMAGTPGIPTAYYFGQEGLHNILVIDLLGPSLEDMFDVCGRKFTPKTVAMLAQQMASPFFCLILNRVESIHEKNLIYRDIKPDNFLIGKPGTESANEVFIVDFGMAKLYRDPRTKQHIPYRERKSLSGTARYMSINTHLGREQSRRDDLEALGHVFMYFLRGSLPWQGLRAATNKQKYEKIGEKKQSTVIRDLCEGYPEEFGIYLQYVRKLGFDEAPDYEFLRELFSKVIKKSGEVEDGVYDWMTLNNGKGWETLSKRQASRQGLPTPAKKVIENNKRQLNGTQGTPAMVSAQETPAISQPVNQDASEPRRKQGLLSKLTCGLCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162ULL4</accession>
    <name>A0A162ULL4_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_158024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440975">
        <property type="protein sequence ID" value="OAD76942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294982.1">
        <property type="nucleotide sequence ID" value="XM_018433716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162ULL4"/>
    <dbReference type="STRING" id="763407.A0A162ULL4"/>
    <dbReference type="GeneID" id="28994622"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_158024"/>
    <dbReference type="InParanoid" id="A0A162ULL4"/>
    <dbReference type="OrthoDB" id="2556847at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD76942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="85" mass="9465" checksum="CB31C20D14327646" modified="2016-07-06" version="1">MLRAQAEHARLTTNQDTQARPPTNSGSASSYANGLAQASALLQNPQFANQYSQLSPELQQQLLRNREQLAALIEQHSKDNKMFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162UXY3</accession>
    <name>A0A162UXY3_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_163805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440973">
        <property type="protein sequence ID" value="OAD78712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018296752.1">
        <property type="nucleotide sequence ID" value="XM_018434872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162UXY3"/>
    <dbReference type="GeneID" id="28995778"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_163805"/>
    <dbReference type="InParanoid" id="A0A162UXY3"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD78712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="111" mass="12943" checksum="6B214C6DC4582A73" modified="2016-07-06" version="1">MILTLQSRYSSFCHFNTCDWIEEYFILEIRNVGIGHIRKVINASNIRRSQKSILIKRIAKDYFWNYLIKTQILDIRTTLKEKVALTPTVVNIAPFPASFIPVLGFFLPLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V479</accession>
    <name>A0A162V479_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">60S acidic ribosomal protein P1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHYBLDRAFT_132288</name>
        <name evidence="6" type="ORF">PHYBLDRAFT_75684</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="Mccluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL 1555</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440976">
        <property type="protein sequence ID" value="OAD76227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD79822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018294267.1">
        <property type="nucleotide sequence ID" value="XM_018429483.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018297862.1">
        <property type="nucleotide sequence ID" value="XM_018443087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V479"/>
    <dbReference type="FunCoup" id="A0A162V479">
        <property type="interactions" value="384"/>
    </dbReference>
    <dbReference type="STRING" id="763407.A0A162V479"/>
    <dbReference type="GeneID" id="28990389"/>
    <dbReference type="GeneID" id="29003993"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_132288"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_75684"/>
    <dbReference type="OrthoDB" id="2194681at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAD76227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAD79822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="10729" checksum="3EB717FEE92FBF7B" modified="2016-07-06" version="1">MSAELAVVYAALILQDDNVEITSDKLQTLVKAAGIEVEPVWFSLYAKALAGQDLKALLLNVGAPGAGGAAAATGAAGAAASTEAAVEEAVEEKEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162V526</accession>
    <name>A0A162V526_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHYBLDRAFT_140034</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the wax synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440972">
        <property type="protein sequence ID" value="OAD80023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018298063.1">
        <property type="nucleotide sequence ID" value="XM_018430321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162V526"/>
    <dbReference type="STRING" id="763407.A0A162V526"/>
    <dbReference type="GeneID" id="28991227"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_140034"/>
    <dbReference type="InParanoid" id="A0A162V526"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF57">
        <property type="entry name" value="OS04G0481900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="9">
        <location>
            <begin position="226"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAD80023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="413" mass="47494" checksum="89F82A1FDDC73341" modified="2016-07-06" version="1">MEISDILKGGENRVSLSALGYIAVMTSIVGLLTYLVTIPTKTLSTNAKRAISIPILLVNFFFPAFLKVDIGFVACGMGLASFASLMRFIELIWTGPFIYGRDAYVPIGYLHEELWKPIRTFYKPESKDIASKEKYIEQENVKDKRYYDIILAWIGNAIICDICTSFSVTYTMKDIEEINSNISVASLLFHCLTIILFTTVFNTLAYPAQLIYVLYYEGGSYSSKEWRPLAKNPILAKSLNEFWAPRWHRIARSPMVNLVYKPVYDFSKRFFSKFIKNPAPLARAAGVFGVFVISGVMHEFIFVWNIGWPVYKERFLGVHMTQFILFGVVLPLELLVGHIASKKIPEFWRRSSITLWIRRFITSVLLHILIYPVLENFHYLGIRYSLPFKVLRPYIHEAIHKFPLLKVLCGSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162VB12</accession>
    <name>A0A162VB12_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UNC-45/Cro1/She4 central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHYBLDRAFT_138898</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV440971">
        <property type="protein sequence ID" value="OAD81352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018299392.1">
        <property type="nucleotide sequence ID" value="XM_018430102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162VB12"/>
    <dbReference type="STRING" id="763407.A0A162VB12"/>
    <dbReference type="GeneID" id="28991008"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_138898"/>
    <dbReference type="InParanoid" id="A0A162VB12"/>
    <dbReference type="OrthoDB" id="26149at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040144">
        <property type="entry name" value="RAP1GDS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10957">
        <property type="entry name" value="RAP1 GTPASE-GDP DISSOCIATION STIMULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAD81352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="684" mass="75615" checksum="1A354D62F5DECCA6" modified="2016-07-06" version="1">MSIDPVEDSLKFLLAIKDADTLLSQTQPIVKAFQHLGALLTKNASDITAWSKATQLAQVVADGARTESTRTPLGEAGVLEKVTDILRLAKEGQTDYQIQALRVYGNMCFDHNDNRQKVHDAGVIPLAIPFLEQGHRPDLVRTCCGFCLNSSMDFEPIQADIATYGGVKLLTELLDPARMDHGEEATVCMAAKVLDNLLGEDSVRKAFSSRESVSRLLEMINYEWNVDQLENLDLLENLADALLQVVLDDDDMQNAVVDSGFFTMLLDFLEKATLPLEAADDEDEKKRFTETQATISKIAVYATSTDEMLERLYADEKTLNRFFRMMNSESSIVSQTAVYALGNLARTDAHCVEMVEKNHLEKSLLKLLTSTENATFQYVILGCLKHLCLPKQNKAVIGNAGAIESVAPLLDTSKDMLKRNQFFAIGILKLLCANNCKPIIPVMNMRFIPRQFVDENSQRIITSPTTTEEKQTPLELVLAFIKRVDDSSAKSEATRILTNLVKSVWTQPITTSLALRTILVKPAIVEPIAELVRSSKFVVLKNDGIIALTVIFADTDSESSKILLKDALSFVIAPVPSLEDMLINQDNDDDDEKKPEEIETRTFLEVVVDTVCKENADIPSEVRCNACVFLEKVALAAQTVNDTKVSNVLYEKVLPQLKALTQGPETVVSFSKKAASAIAKSTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162WTA1</accession>
    <name>A0A162WTA1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_170898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440987">
        <property type="protein sequence ID" value="OAD70815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018288855.1">
        <property type="nucleotide sequence ID" value="XM_018436446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162WTA1"/>
    <dbReference type="STRING" id="763407.A0A162WTA1"/>
    <dbReference type="GeneID" id="28997352"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_170898"/>
    <dbReference type="InParanoid" id="A0A162WTA1"/>
    <dbReference type="OrthoDB" id="2209168at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD70815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="132" mass="15742" checksum="1392C50304264F27" modified="2016-07-06" version="1">MSQYIASNKQDGYRNVIDENCGPEPMEYIFNQDKCIVEMFAAHSEYLNNKISNEFSPACPTRIEKPKDKDIRIKEPNVKRDYVRYTILSIKKKYTVEPKHWNKSFCGTVLWMLSYSLTRTKEQEHDKYLIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162X6D9</accession>
    <name>A0A162X6D9_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Glycoside hydrolase family 28 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHYBLDRAFT_57294</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD72795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018290835.1">
        <property type="nucleotide sequence ID" value="XM_018440232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162X6D9"/>
    <dbReference type="STRING" id="763407.A0A162X6D9"/>
    <dbReference type="GeneID" id="29001138"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_57294"/>
    <dbReference type="InParanoid" id="A0A162X6D9"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF12">
        <property type="entry name" value="EXO-POLYGALACTURONASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 15 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007840915" evidence="16">
        <location>
            <begin position="19"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAD72795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="392" mass="42671" checksum="62F08B813CCBE7F0" modified="2016-07-06" version="1">MKASLILISCWLISSALARKTCVIPASKVSGADDSLAIIDAFSRCKKNGEVVFSKGTTYNVQKAMNITGLDDVHISLRGKVLFSDDMEYWQKNIFALNFQSAGTWWVIGGRKIIMNGGGTIDGNGQVWWDAQAIDPRPVALTFDKVTDLKVEDVSFAQAPFWHLFVRDAQDVIFDRINIRSVTNSTFPTHNSDGWDLFRSSNVVIKNSVIVNGDDCVSLKANATDVTIKNLSCTGSHGVSIGSLGQYSGIGQIDVVKNVLVKDVTCINCSNGARIKTWPGGLGLVENITFDHMNVTNVDYPVMITTHYCDNNQMEFCSGADTHSLTIKDVVFNDIYGTISSAKKPIVSLNCSSETPCSNISLTKIKITPTASTPKNVCDYVTGSENISYCNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162X7U1</accession>
    <name>A0A162X7U1_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHYBLDRAFT_169303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440982">
        <property type="protein sequence ID" value="OAD73045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018291085.1">
        <property type="nucleotide sequence ID" value="XM_018436038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162X7U1"/>
    <dbReference type="GeneID" id="28996944"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_169303"/>
    <dbReference type="InParanoid" id="A0A162X7U1"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAD73045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="106" mass="12399" checksum="046F422E8FD24FB5" modified="2016-07-06" version="1">MRDFIGLRYSELTKDFRTCEGQQSSTLHRIRPIPTKISVKTMIIPTHFQITVILSSSIVFFSEVIVESILYCFQEFLIFSLCCCFFTASVPIVVNSRYYYNFWAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XDL8</accession>
    <name>A0A162XDL8_PHYB8</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHYBLDRAFT_144610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL 1555(-)</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292195.1">
        <property type="nucleotide sequence ID" value="XM_018431251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XDL8"/>
    <dbReference type="GeneID" id="28992157"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_144610"/>
    <dbReference type="InParanoid" id="A0A162XDL8"/>
    <dbReference type="OrthoDB" id="2272203at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAD74155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077315"/>
        </source>
    </evidence>
    <sequence length="159" mass="18668" checksum="0848CA6277D4BD4C" modified="2016-07-06" version="1">MHVNRPLNVTLFQHIFLASVQQKSILEKRFRPATNSTKQIEGWINSCNAWGERTAMKSNGKRLEGRWLWVFLDKHLGINVTEDLVKYEQHCRHHPMTTIGYARKSKGKERINTRCNLLSEMIHRLRTRSLCTKVYISSCCDAKETINITWHWSRTVMGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A162XF56</accession>
    <name>A0A162XF56_PHYB8</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3 8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHYBLDRAFT_167893</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)</name>
        <dbReference type="NCBI Taxonomy" id="763407"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Phycomycetaceae</taxon>
            <taxon>Phycomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Expansion of signal transduction pathways in fungi by whole-genome duplication.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Corrochano L.M."/>
                <person name="Kuo A."/>
                <person name="Marcet-Houben M."/>
                <person name="Polaino S."/>
                <person name="Salamov A."/>
                <person name="Villalobos J.M."/>
                <person name="Alvarez M.I."/>
                <person name="Avalos J."/>
                <person name="Benito E.P."/>
                <person name="Benoit I."/>
                <person name="Burger G."/>
                <person name="Camino L.P."/>
                <person name="Canovas D."/>
                <person name="Cerda-Olmedo E."/>
                <person name="Cheng J.-F."/>
                <person name="Dominguez A."/>
                <person name="Elias M."/>
                <person name="Eslava A.P."/>
                <person name="Glaser F."/>
                <person name="Grimwood J."/>
                <person name="Gutierrez G."/>
                <person name="Heitman J."/>
                <person name="Henrissat B."/>
                <person name="Iturriaga E.A."/>
                <person name="Lang B.F."/>
                <person name="Lavin J.L."/>
                <person name="Lee S."/>
                <person name="Li W."/>
                <person name="Lindquist E."/>
                <person name="Lopez-Garcia S."/>
                <person name="Luque E.M."/>
                <person name="Marcos A.T."/>
                <person name="Martin J."/>
                <person name="McCluskey K."/>
                <person name="Medina H.R."/>
                <person name="Miralles-Duran A."/>
                <person name="Miyazaki A."/>
                <person name="Munoz-Torres E."/>
                <person name="Oguiza J.A."/>
                <person name="Ohm R."/>
                <person name="Olmedo M."/>
                <person name="Orejas M."/>
                <person name="Ortiz-Castellanos L."/>
                <person name="Pisabarro A.G."/>
                <person name="Rodriguez-Romero J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Ruiz-Vazquez R."/>
                <person name="Sanz C."/>
                <person name="Schackwitz W."/>
                <person name="Schmutz J."/>
                <person name="Shahriari M."/>
                <person name="Shelest E."/>
                <person name="Silva-Franco F."/>
                <person name="Soanes D."/>
                <person name="Syed K."/>
                <person name="Tagua V.G."/>
                <person name="Talbot N.J."/>
                <person name="Thon M."/>
                <person name="De vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Yadav J.S."/>
                <person name="Braun E.L."/>
                <person name="Baker S."/>
                <person name="Garre V."/>
                <person name="Horwitz B."/>
                <person name="Torres-Martinez S."/>
                <person name="Idnurm A."/>
                <person name="Herrera-Estrella A."/>
                <person name="Gabaldon T."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL 1555(-)</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3 8"/>
    <dbReference type="EMBL" id="KV440979">
        <property type="protein sequence ID" value="OAD74485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018292525.1">
        <property type="nucleotide sequence ID" value="XM_018435741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A162XF56"/>
    <dbReference type="STRING" id="763407.A0A162XF56"/>
    <dbReference type="GeneID" id="28996647"/>
    <dbReference type="VEuPathDB" id="FungiDB:PHYBLDRAFT_167893"/>
    <dbReference type="InParanoid" id="A0A162XF56"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000077315">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-ty
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